Medicine and Health Sciences Commons^™

The Efficacy Of The Student Communication Repair Inventory And Practical Training Program On Adolescent’S Self-Advocacy Skills In Communication Breakdowns, Karlye Tolbird

Honors Theses

Purpose

Hearing loss can affect several aspects of an adolescent’s life, particularly their self-advocacy skills and ability to communicate their needs in the classroom. Literature shows that adolescents between the ages of 12 and 18 years have a prevalence of hearing loss between 14.9 percent and 19.5 percent (Shargorodsky et al., 2010). Therefore, early identification and intervention of hearing loss are necessary to reduce the adverse effects on the development of cognition, verbal communication skills, and self-advocacy skills (Michael & Zidan, 2018). This research study aimed to determine if the implementation of the SCRIPT program changes the communication repair behavior …

Synthetic Investigations In Chemical Probe Development Part 1: Design And Synthesis Of Novel Triton X-405 Adenosine Conjugates; Part 2: Synthesis Of 2,8-Dihydroxychrysene, Rachel Irene Hammond

Honors Theses

Although not drugs themselves, chemical probes are a necessary tool in biomedical research for the interrogation of biological systems. In the present synthetic investigation, two chemical probes were developed – a Triton X-405 adenosine conjugate (TX-405A) and 2,8-dihydroxychrysene. The designed TX-405A conjugate was generated in four steps through tosylation and amination of TX-405 such that EDC-coupling of TX-amine with 2’,3’-Isopropylidene adenosine-5’-carboxylic acid afforded TX-405A following acetonide deprotection. The development of TX-405A represents the first report of the synthesis and utilization of a detergent-linked dosimeter. The synthesis of 2,8-dihydroxychrysene provided an in-depth exploration on the unique reactivity of chrysene. The desired …

Evaluating The Impact Of An Evidence Based Practice Education Program In A Nurse Residency Program On Evidence Based Practice Beliefs, Implementation And Competency, Amy Hu

Doctoral Projects

For organizations to ensure that they are providing safe and quality patient care, they must promote a culture of care based on Evidence Based Practice (EBP). To improve healthcare quality nurses must make care decisions based on the most current scientific evidence. In fact the Institute of Medicine set a goal that 90% of clinical decisions be evidence based by 2020 (Institute of Medicine, 2008). Unfortunately it can take up to 15-20 years for newly discovered treatments to be implemented into patient care (Institute of Medicine, 2001). Healthcare providers continue to base healthcare decisions on outdated practices derived from tradition …

The Synthesis And Characterization Of Ionic Liquids Using Nitrogen-Based Cations For Transdermal Delivery, Jo Galloway

Honors Theses

The purpose of this research was to explore the synthesis mechanisms of water-soluble ionic liquids with nitrogen-containing cationic bases for future use in transdermal drug delivery and forensic science applications. Ionic liquids are salts with an organic cation and either an organic or inorganic anion. They have asymmetric structures, which means that the molecules don’t pack together as neatly as other salts do, therefore, they don’t crystallize as easily, and their melting points are lower. Ionic liquids have melting points below 100°C, and many are liquid at room temperature. Mechanistic studies reveal that the potency of ILs in enhancing transdermal …

A Systematic Review Of Music Therapy For Children With Autism Spectrum Disorder, Alana Andrus

Honors Theses

Music therapy has been suggested to be effective in Autism. The purpose of this systematic review was to assess the effectiveness of music therapy as a potential treatment option for individuals with autism spectrum disorder, or ASD. To obtain published records, a PubMed search was conducted with the search term “music therapy autism,” which generated 187 studies. Each study was evaluated for relativity to the topic at hand. The remaining 151 articles were assessed for support status, as well as other later suggested research, in order to more confidently support music therapy as a treatment option for ASD patients. Approximately …

Trends In Prenatal Care Accessibility In Rural Mississippi And How These Trends Affect Unfavorable Birth Outcomes, Maura Isabella Webb

Honors Theses

This thesis investigated the level of accessibility to prenatal care in rural Mississippi areas and how this affects or has affected Mississippi’s high rates of unfavorable birth outcomes. The research questions included specifically looked at how lack of prenatal care in rural areas of Mississippi plays a role, if any, in extremely high rates of unfavorable birth outcomes as well as what policy can be implemented to expand education regarding unfavorable birth outcomes. To understand the effects of accessibility and eligibility of rural women’s health care, seven women were interviewed. Interviews were conducted with these women who met the criteria …

The Use Of Embark In Teaching About Genetic Relatedness, Anna Bonvillain, Tori Trammel

Honors Theses

Because of the increasing importance of precision medicine, it is vital that future healthcare providers master concepts related to genetic variation taught during their undergraduate classes. However, studies have shown that physicians often lack an adequate understanding of genetics, which serves as a hindrance to effectively caring for their patients. To address this issue, we created a collaborative active-learning protocol to improve pre-health students' comprehension of key concepts such as genetic relatedness and the source of genetic variation between siblings. Our worksheet guides students to compare the genetic profiles of two canine siblings using the Embark DNA genotyping platform. Embark …

Resilience Training And Quality Of Life In Stuttering Therapy: A Systematic Review, Ashley Koehler

Honors Theses

Abstract

This study investigated correlations between resilience and quality of life relative to stuttering therapy. A systematic review and meta-analysis of articles published with focuses on stuttering, resilience training, and quality of life was conducted. Electronic databases, PubMed, and Google Scholar, were used to gain results of relevant published articles. Both search engines in this review produced relevant articles. Google Scholar produced more articles that met all 3 inclusion criteria, while PubMed produced more results that met at least 1 or 2 inclusion criteria. From both databases, numerous articles included the need for a multidimensional therapy emphasizing personal resilience. However, …

Patients’ Perspective Of Patient-Centered Approach Vs. Biomedical Approach, Lakynn Hillhouse

Honors Theses

Evidence-based practice in audiology may consist of a patient-centered approach or a biomedical approach when offering individuals the results of hearing evaluations. Boisvert et al. (2017) and the Institute for Defense Analysis confirmed that audiologists preferred to select one approach. The question was if an audiology patient is presented with two options of explaining the hearing health issues, which model/approach will be his or her preference?

Participants may have had unconscious biases related to race or gender that could have unknowingly impacted their perception of the videos. The results of this research will facilitate clinical understanding of individual preferences regarding …

The Effects Of Short-Term Indoor And Personal Exposure To Fine Particulate Matter (Pm2.5) On Cardiovascular Health: A Review, Whitley Cagle

Honors Theses

Fine Particulate Matter (PM2.5), a component of air pollution, has known effects on human health. However, there is limited research surrounding the specific cardiovascular impacts associated with these small particles entering into the bloodstream. This literature review aims to make associations between indoor and personal exposures to PM2.5 and cardiovascular health. An online search was conducted to obtain scholarly articles using various key terms, and the articles were filtered through based on specific selection criteria. In the final review, we focused on 37 research articles which discussed PM2.5 and its effects on the human cardiovascular system. Positive associations between PM2.5 …

The Effects Of Thc On Hiv Tat Protein-Mediated Neuroinflammation, Camille Martin

Honors Theses

Although antiretroviral therapies have allowed people living with human immunodeficiency virus (HIV) to achieve normal life expectancies, they cannot cure HIV nor the neurological symptoms associated with infection, termed neuroHIV. NeuroHIV describes a myriad of neurological disorders including mood disorders (depression and anxiety), cognitive impairment, neuropathic pain, and motor disinhibition. The mechanisms by which HIV promotes neurological impairment are not known, but may involve actions of its neurotoxic proteins. One such protein that has been well-characterized is the HIV trans-activator of transcription (Tat). Tat exerts neurotoxic effects via various means, one of which is to activate microglia, the macrophages of …

An Exploratory Look Into The Effects Of Mississippi's Population Decline On Rural Dental Care, Allen Bailey Saffold

Honors Theses

Literature reviews and interviews with dentists working in rural Mississippi counties examined the effects of population decline on rural dental care in Mississippi. With the state’s continual population decline, loss of industry follows a loss of people. Through a cascade of effects, this can further reduce underserved areas’ access to dental care. In order to address the issue of rural Mississippi continuing to be underserved, policies need to be implemented that will make rural practice at least enticing if not desirable.

Lc-Ms Identification Of Serum Proteins Adsorbed Onto Ionic Liquid-Coated Nanoparticles, Anh M. Hoang

Honors Theses

Nanocarriers are promising candidates for drug delivery due to their size and tunable surface characteristics. However, when they are intravenously injected, few particles make it to their designated location. This is because upon entering the bloodstream, the serum in the blood, which is rich with a diversity of proteins, adsorbs onto the particles’ surfaces forming a protein corona. Many of the attached proteins trigger the mobile immune system and are removed by macrophages, and many particles are then filtered out by the liver and kidneys. Ionic Liquids (ILs), which consist of asymmetric, bulky components that are liquid

The Efficacy Of Tailored Text Messages To Improve Medication Adherence And Lifestyle Changes For Patients With Type 2 Diabetes Mellitus, Vanessa B. Silverio

Evidence-Based Practice Project Reports

Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by increased amounts of glucose in the blood, and is the seventh leading cause of death in the United States (United Health Foundation [UHF]), 2021). T2DM can be effectively treated with medication and behavioral lifestyle modifications. Even small improvements in glycemic control can reduce the risk for debilitating complications such as heart disease, stroke, kidney disease, sepsis, and retinopathy (Wang et al., 2021, Haider et al., 2019). The purpose of this evidence-based practice (EBP) project was to identify the most effective intervention for improving medication adherence, lifestyle changes, and hemoglobin …

The Detection Of Human Antibodies Against Differing Sars-Cov-2 Virus Proteins By Immunoblot Testing, Virginia Kate Gammon

Honors Theses

The emergence of the coronavirus disease (COVID-19) has instigated one of the most influential pandemics, causing unique and detrimental effects throughout various parts of the world. By developing a stronger understanding of the viral genome and structural components, researchers are driven towards medical advancements and the implementation of improved testing methods. This research aims to provide a reliable COVID-19 antibody test by immunoblot detection, which can deliver more accurate results than the currently used enzyme linked immunosorbent assay (ELISA). Within this protocol, differing SARS-CoV-2 viral proteins were detected through western blotting analysis and were evaluated based upon differing strengths in …

Student Engagement And Performance Assessment As Associated With Three Types Of Integument System Laboratory Activities, Sophie Deoliveira

Honors Theses

Students participating in anatomy education, specifically an Anatomy and Physiology classroom, have shown difficulty in learning and retaining information on the various systems of the body. This study sought to assess the benefits of different learning activities associated with student engagement and performance on subsequent examinations regarding the integumentary system. For this study, three different hands-on laboratory activities (i.e., treatments) were given during different laboratory sessions. These hands-on activities included labeling a three-dimensional model, illustrating a model, or building a model of the integumentary system using materials provided. Students then completed a post-laboratory questionnaire regarding their enjoyment of their particular …

Assessment Of Motivation In Human Anatomy And Physiology Students, Mary Whitehead

Honors Theses

Motivation is the key to success in difficult science courses such as Human Anatomy and Physiology. Students may possess intrinsic motivation, or motivation for enjoyment, extrinsic motivation, or motivation for a reward, or amotivation, a lack of motivation at all. The goal of this experiment was to identify better ways of helping students succeed in Human Anatomy and Physiology (HAP) at the University of Mississippi, determine when motivational efforts seem to decrease during the semester, and identify how to better develop intrinsic motivation in students. There was a significant relationship between many of the student’s survey responses to their exam …

Lectin-Glycan Complexes: A Comprehensive Analysis Of Docking Calculations, Ashton Custer

Honors Theses

Lectins are a type of glycan-binding protein that noncovalently bind glycans. Carbohydrates are molecules consisting of sugar units joined together. Glycans are carbohydrates. Hence, glycans are also sugars. Lectins and lectin-glycan complexes have a range of biological roles and can be found in animals (including humans), plants, bacteria, viruses, and yeasts and fungi.¹ Many scientists focus on the computational study of these complexes due to their intricate roles in many living organisms. Computational study is important in furthering our knowledge of lectin-glycan complexes and other such protein complexes. However, computational study is not perfect. There are many challenges in …

A Study Of Dextran As A Macromolecular Crowding Agent, Katherine Morgan

Honors Theses

Deoxyribonucleic acid (DNA) is the hereditary material in all living organisms. According to the Watson and Crick model, DNA exists as two long strands coiled into a double helix. However, DNA has been found to have the potential to exist in secondary forms known as G-Quadruplexes and i-motifs. I-motifs (intercalated-motif or iM) are formed under acidic conditions when sets of cytosines pair with protonated cytosines and are looped around each other. The pKa value for iMs in dilute solutions is approximately 6.5, but iMs can potentially exist at a higher, physiological pH value under crowded conditions. Within the interior of …

The Effects Of Astrocytic Derived Insulin-Like Growth Factor (Igf-1) On Cognition And Astrocytes, Destiny Wilson

Honors Theses

Insulin-like growth factor 1 (IGF-1) is a neuroendocrine signaling hormone that plays a vital role in growth and development, as well as learning and memory. Inhibition of this hormone results in cognitive impairments like those seen with age-related decline. While a majority of research has focused on the role of IGF-1 on neurons, the role of astrocytes still needs to be explored. Our research investigates how astrocytes and cognition are affected as a result of direct regulation of localized IGF-1 production in early development and after puberty. Preliminary studies in our laboratory established a connection between IGF-1 and glial fibrillary …

Comorbidity Burden And Covid-19 Vaccination Intention: Application Of The Health Belief Model, Michael Raymond

Honors Theses

The COVID-19 pandemic impacted many aspects of American’s lives causing over 79 million cases and over 950,000 deaths. Existing research shows severity of COVID-19 infection may be linked to number of underlying health conditions, known as comorbidities. The objective of this study was to determine if comorbidity burden was associated with intention to vaccinate against COVID-19. This relationship was looked at through the Health Belief Model (HBM) and its mediating variables of perceived susceptibility, perceived severity, perceived benefits, and perceived barriers. Our sample was compromised of 350 individuals recruited from an online platform who were not already vaccinated against COVID-19. …

Rates And Perceptions Of Covid-19 Vaccination From University Of Mississippi Students, Josie Parham

Honors Theses

The trials, tribulations and triumphs of the global COVID-19 pandemic are impacted by and are a product of behaviors that occur at the level of nations, states, cities and, ultimately, communities. In the wake of the development of safe and effective vaccines against SARS-CoV2, the virus responsible for the pandemic, the significance of the vaccine is closely linked to the number of individuals that receive the vaccine. To date, surveys have measured sizable variations in vaccination rates between nations, states, cities, and communities. Focusing on events that have transpired in one such local community, the present study (i) measured the …

Isolation Of Sphingolipids From Sphingomonas Echinoides B-3126 And Their Characterization By Ms/Ms Analysis, Edgar David Uribe Sanchez

Honors Theses

EDGAR DAVID URIBE SANCHEZ: Isolation of Sphingolipids from Sphingomonas echinoides B-3126 and their Characterization by MS/MS Analysis

Sphingolipids are important components in human cellular lipid membranes and are differentiated by the incorporation of serine with an amide bond between the amino acid and a lipid tail. Sphingolipids produced by bacteria differ in both headgroups attached to the serine alcohol and the architecture of the lipid backbone. While the synthesis of sphingolipids in mammalian cells is well studied, only a handful of steps in the pathway are described in bacteria.¹ The observations that although sphingolipid synthesis is rare in bacteria, …

Resilience Training & Parental Support For Children Who Stutter - A Systematic Review, Rachel Elizabeth Davis

Honors Theses

The objective of this study was to investigate the relationship between emotional resilience and family/parental/caregiver support for children who stutter, and to review existing research on resilience training and family support relative to enhancing the quality of life in children who stutter. Thus, A systematic review of appropriate published studies was conducted utilizing the electronic databases PubMed and Google Scholar. Analysis revealed that there is an abundance of research supporting parental support and resilience training; however, there was limited direct clinical application relative to the unification of these concepts. Data indicates that the clinical application of emotional resilience and cognitive …

Intensive, Interprofessional Therapy: A Case Approach, Emma C. Schrotenboer

Honors Theses

This research looks at the impacts of intensive, interprofessional therapy for children with disabilities. There is very little literature currently published on this topic, although what is available generally finds that more intense therapy is more beneficial. The child who was studied was a camper at Adam’s Camp therapy camp, a week-long program that involves six hours of therapy each day with therapists from five different fields. Her progress over the week, as well as her retention of skills several weeks later, were determined by pre- and post-camp surveys sent to the mother and the therapists’ notes from during the …

Stability And Flexibility In Psychotherapy Process Predict Outcome, Giulio De Felice, Alessandro Giuliani, David Pincus, Andrea Scozzari, Vincent Berardi, Leonhard Kratzer, Wolfgang Aichhorn, Helmut J. Schöller, Kathrin Viol, Günter Schiepek

Psychology Faculty Articles and Research

Ten good outcome and ten poor outcome psychotherapy cases were compared to investigate whether or not the temporal stability and flexibility of their process variables can predict their outcomes. Each participant was monitored daily using the Therapy Process Questionnaire (TPQ), which has 43 items and seven sub-scales, and responses over time were analyzed in terms of correlation robustness and correlation variability across the TPQ sub-scales. “Correlation robustness” and “correlation variability” are two basic characteristics of any correlation matrix: the first is calculated as the sum of the absolute values of Pearson correlation coefficients, the second as the standard deviation of …

Preventing Self-Harm Among Adolescent Victims Of Adverse Child Experiences Integrated Review, Irene Tsimba Zenga, Trinette Radasta, Julie Maxworthy

DNP Qualifying Manuscripts

Background: Evidence shows a clear connection between adverse childhood experiences (ACEs) and mental health disorders in adolescence. If not treated, adolescent victims of ACEs could develop maladaptive behaviors such as self-mutilation and suicidal ideation. The standard therapies to treat this population are psychotropic medications or cognitive behavior therapy.

Search Methodology: Ten studies from a literature search on CINAHL, PubMed, APA PsychInfo, and Joanna Briggs databases were selected, appraised, and reviewed.

Integrated Review: Studies were grouped into six types: (a) screening for ACEs, (b) usual care and alternative therapies, (c) ineffectiveness of usual care, (d) comprehensive treatment that included trauma-informed therapy, …

Deep Phenotyping: Symptom Annotation Made Simple With Sams., Robin Steinhaus, Sebastian Proft, Evelyn Seelow, Tobias Schalau, Peter N Robinson, Dominik Seelow

Faculty Research 2022

Precision medicine needs precise phenotypes. The Human Phenotype Ontology (HPO) uses clinical signs instead of diagnoses and has become the standard annotation for patients' phenotypes when describing single gene disorders. Use of the HPO beyond human genetics is however still limited. With SAMS (Symptom Annotation Made Simple), we want to bring sign-based phenotyping to routine clinical care, to hospital patients as well as to outpatients. Our web-based application provides access to three widely used annotation systems: HPO, OMIM, Orphanet. Whilst data can be stored in our database, phenotypes can also be imported and exported as Global Alliance for Genomics and …

Sex Differences In The Association Between Cardiovascular Diseases And Dementia Subtypes: A Prospective Analysis Of 464,616 Uk Biobank Participants, Caiyun Dong, Chunmiao Zhou, Chunying Fu, Wenting Hao, Akihiko Ozaki, Nipun Shrestha, Salim S. Virani, Shiva Raj Mishra, Dongshan Zhu

Office of the Provost

Background: Whether the association of cardiovascular diseases (CVDs) with dementia differs by sex remains unclear, and the role of socioeconomic, lifestyle, genetic, and medical factors in their association is unknown.
Methods: We used data from the UK Biobank, a population-based cohort study of 502,649 individuals. We used Cox proportional hazards models to estimate sex-specific hazard ratios (HRs) and 95% confidence intervals (CI), and women-to-men ratio of HRs (RHR) for the association between CVD (coronary heart diseases (CHD), stroke, and heart failure) and incident dementia (all-cause dementia, Alzheimer's Disease (AD), and vascular dementia (VD)). The moderator roles of socioeconomic (education, income), …

The Parent Perspective On Augmentative And Alternative Communication: A Qualitative Study, Alicia Larouech

Honors Capstones

Parents are known to be effective communication partners in their child’s augmentative and alternative communication (AAC) intervention. The aim of this interview study was to better understand the parent perspective in the AAC acquisition, implementation, and handing processes across a range of primary disability labels and ages. Participants engaged in phone interviews to discuss their family’s experiences with AAC obtainment and intervention. Qualitative review of their responses developed the following five themes: assessment procedures, external variables that influence device use, barriers of AAC navigation, supports parents have indicated have helped them, and major takeaways as identified by parents. Further subthemes …