Medicine and Health Sciences Commons^™

Tungsten-Enhanced Breast Cancer Metastasis To The Bone Is Associated With Alterations In The Bone Niche., Cameron J. Chock, Alicia Bolt

Pharmaceutical Sciences ETDs

The objective of this thesis project was to investigate the effects of tungsten on breast cancer metastasis to the bone niche, using the 4T1 orthotopic breast cancer model. Oral tungsten (15 ppm) exposure did not affect primary tumor growth. However, following tungsten exposure there were marked changes in the bone niche, including increased metastasis of 4T1 tumor cells and increased osteolysis. Further analysis of the bone niche indicates that enhanced metastasis is associated with a pro-tumorigenic immune suppressive environment, including increased number of granulocytic myeloid derived suppressor cells and increased gene expression of the pro-inflammatory cytokine IL-1β and the activated …

Seasonal Variation And Tracking Of Climate Niche Of A Migratory Bird, Javier Gutiérrez Illán, Guiming Wang, D. Tommy King, Fred L. Cunningham

United States Department of Agriculture Wildlife Services: Staff Publications

Migratory birds inhabit different areas during breeding and non-breeding seasons. Depending on the time of the year, they may utilize different resources available in seasonal habitats, but also are subjected to changing climate regimes during their annual life cycle. Migratory birds may adopt ecological niche tracking to cope with different environmental conditions between breeding and non-breeding grounds. The American White Pelican (Pelecanus erythrorhynchos, hereafter ‘AWPE’) is a short-distance migrant between the Gulf of Mexico coastal regions (nonbreeding grounds) and the Northern Great Plains (breeding grounds) of Canada and the US. The American White Pelican is a piscivore, feeding …

A Genome-Wide Crispr-Cas9 Knockout Screen Identifies Essential And Growth-Restricting Genes In Human Trophoblast Stem Cells, Chen Dong, Shuhua Fu, Rowan M Karvas, Brian Chew, Laura A Fischer, Xiaoyun Xing, Jessica K Harrison, Pooja Popli, Ramakrishna Kommagani, Ting Wang, Bo Zhang, Thorold W Theunissen

2020-Current year OA Pubs

The recent derivation of human trophoblast stem cells (hTSCs) provides a scalable in vitro model system of human placental development, but the molecular regulators of hTSC identity have not been systematically explored thus far. Here, we utilize a genome-wide CRISPR-Cas9 knockout screen to comprehensively identify essential and growth-restricting genes in hTSCs. By cross-referencing our data to those from similar genetic screens performed in other cell types, as well as gene expression data from early human embryos, we define hTSC-specific and -enriched regulators. These include both well-established and previously uncharacterized trophoblast regulators, such as ARID3A, GATA2, and TEAD1 (essential), and GCM1, …

Ezh2 Engages Tgfβ Signaling To Promote Breast Cancer Bone Metastasis Via Integrin Β1-Fak Activation, Lin Zhang, Jingkun Qu, Yutao Qi, Yimin Duan, Yu-Wen Huang, Ping Li, Beibei Huang, Shuxing Zhang, Dihua Yu

Faculty, Staff and Student Publications

Bone metastases occur in 50-70% of patients with late-stage breast cancers and effective therapies are needed. The expression of enhancer of zeste homolog 2 (EZH2) is correlated with breast cancer metastasis, but its function in bone metastasis hasn't been well-explored. Here we report that EZH2 promotes osteolytic metastasis of breast cancer through regulating transforming growth factor beta (TGFβ) signaling. EZH2 induces cancer cell proliferation and osteoclast maturation, whereas EZH2 knockdown decreases bone metastasis incidence and outgrowth in vivo. Mechanistically, EZH2 transcriptionally increases ITGB1, which encodes for integrin β1. Integrin β1 activates focal adhesion kinase (FAK), which phosphorylates TGFβ receptor type …

Identification Of Biomarkers Of Response To Preoperative Talazoparib Monotherapy In Treatment Naïve Gbrca+ Breast Cancers, Xuan Liu, Zhongqi Ge, Fei Yang, Alejandro Contreras, Sanghoon Lee, Yiling Lu, Banu K Arun, Stacy L Moulder, Gordon B Mills, Helen Piwnica-Worms, Jennifer K Litton, Jeffrey T Chang

Faculty, Staff and Student Publications

Germline mutations in BRCA1 or BRCA2 exist in ~2-7% of breast cancer patients, which has led to the approval of PARP inhibitors in the advanced setting. We have previously reported a phase II neoadjuvant trial of single agent talazoparib for patients with germline BRCA pathogenic variants with a pathologic complete response (pCR) rate of 53%. As nearly half of the patients treated did not have pCR, better strategies are needed to overcome treatment resistance. To this end, we conducted multi-omic analysis of 13 treatment naïve breast cancer tumors from patients that went on to receive single-agent neoadjuvant talazoparib. We looked …

Holographic Cell Differentiation In Mixed-Species Populations, Matt Phillips, Cole Anderson, Savannah Holmes, Ezra Wylie, Ellie Evans, Thiago Vecchi, Taylor Murphy, Clint Flinders, Hunter Houtz, Carson Stubbs, Vern Hart

Utah Space Grant Consortium

Survival rates for most cancers have increased steadily over the past few decades as new technologies have led to better treatment outcomes. However, this process often relies heavily on the detection of cancer in its earliest stages, before symptoms occur or a tumor is visible in a CT or MR image. This is particularly true for diseases such as pancreatic cancer that exhibit almost no symptoms until very late stages and have extremely low survival rates as a result. Even some commonly treatable diseases, such as breast cancer, become far more problematic in later stages. As such, any efforts to …

Enhanced Neural Network-Based Cell Identification Through Vectorized Phase Information In Reconstructed Holograms, Tyler Daynes, Jeremy Tait, Rylee Russell, Harrison Welch, Vern Hart

Utah Space Grant Consortium

Survival rates for most cancers have increased steadily over the past few decades as new technologies have led to better treatment outcomes. However, this process often relies heavily on the detection of cancer in its earliest stages, before symptoms occur or a tumor is visible in a CT or MR image. This is particularly true for diseases such as pancreatic cancer that exhibit almost no symptoms until very late stages and have extremely low survival rates as a result. Even some commonly treatable diseases, such as breast cancer, become far more problematic in later stages. As such, any efforts to …

Urine Oxygen Partial Pressure Monitoring To Assess Acute Kidney Injury Risk, Lars Lofgren, Kai Kück, Natalie Silverton

Utah Space Grant Consortium

Acute kidney injury (AKI) is a common complication associated with cardiac surgery. AKI is associated with increased hospital costs, hospital length of stay (LOS), and mortality risk. The KDIGO criteria are the most common diagnostic criteria and are based on changes in serum creatinine and decreased urine output. While useful for estimating renal function, serum creatinine and urine output are not renal specific, can be influenced by factors other than kidney injury and lead to delayed AKI diagnosis which precludes injury prevention. To overcome these limitations, researchers have primarily focused on chemical biomarkers. The use of these tests is limited …

Investigating The Effects Of Radiation And Microgravity On Human Brain Organoids, Bailey Mcfarland, Chen Cheng, Yu Huang

Utah Space Grant Consortium

The brain is arguably the most important and complex component of any crewed mission. New technological developments must be made to gauge the damage of space to the brain, especially in complex and long-term missions. While it is understood that microgravity and radiation cause changes in the brain of astronauts, the nature and effects of these changes are largely unknown. To aid in elucidating these effects, we conducted experiments using a rotary cell culture system (RCCS) and are working actively with NASA to implement a chronic low-dose gamma radiation system. Initial trends in the effects of microgravity on brain organoids …

Nurses Partnering With Technology To Predict The Patients' Risk Of Falling Using Artificial Intelligence, Ann Aquino

DNP Qualifying Manuscripts

Artificial intelligence's influence on human lives has captured the attention of healthcare professionals around the globe. There is high optimism for healthcare transformation for better and more efficient care delivery using technology in a highly complex work environment. Because of machine-learning models, predicting the likelihood of harm, such as a fall, is possible. Artificial intelligence (AI) calculations create predictive analytics that can be an objective mediator between the patients' clinical presentation and the nurse's judgment. Further, standardization of documentation is made possible because of the technology behind AI. Information models create a clinical support system that guides nurses in preventing …

Ada News - 05/09/2022, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

2022-05-09 Michiganoverview_Covidoutbreak, Michigan Department Of Health & Human Services

Michigan COVID-19 Outbreak Reports

The Outbreak Data page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/stats/outbreak-reporting.

This report is created by the Michigan Department of Health & Human Services from data self-reported by local health departments. Data is updated every week.

COVID-19 outbreaks are generally defined as two or more cases with a link by place and time indicating a shared exposure outside of a household. Local health departments report the number of new and ongoing outbreaks they are investigating by the setting of the outbreak. New outbreaks are those outbreaks that were first identified during the current reporting week. Ongoing outbreaks are …

2022-05-09 Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

2022-05-09_Michiganoverview_Covidschooloutbreak, Michigan Department Of Health & Human Services

Michigan COVID-19 Outbreak Reports

The School Outbreak Data page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/stats/school-outbreak.

This report is created by the Michigan Department of Health & Human Services from data self-reported by local health departments. Data is updated every week.

K-12 School-Related Outbreak Reporting: In accordance with the Council of State and Territorial Epidemiologists' outbreak definition, a K-12 school-associated COVID-19 case (confirmed or probable) is defined as a student, teacher, or staff member physically present in the school setting or participated in a school sanctioned extracurricular activity within 14 days prior to illness onset (or a positive test result) OR …

Central Nervous System Immune Interactome Is A Function Of Cancer Lineage, Tumor Microenvironment, And Stat3 Expression., Hinda Najem, Martina Ott, Cynthia Kassab, Arvind Rao, Ganesh Rao, Anantha Marisetty, Adam M Sonabend, Craig Horbinski, Roel G W Verhaak, Anand Shankar, Santhoshi N Krishnan, Frederick S Varn, Víctor A Arrieta, Pravesh Gupta, Sherise D Ferguson, Jason T Huse, Gregory N Fuller, James P Long, Daniel E Winkowski, Ben A Freiberg, Charles David James, Leonidas C Platanias, Maciej S Lesniak, Jared K Burks, Amy B Heimberger

Faculty Research 2022

BACKGROUNDImmune cell profiling of primary and metastatic CNS tumors has been focused on the tumor, not the tumor microenvironment (TME), or has been analyzed via biopsies.METHODSEn bloc resections of gliomas (n = 10) and lung metastases (n = 10) were analyzed via tissue segmentation and high-dimension Opal 7-color multiplex imaging. Single-cell RNA analyses were used to infer immune cell functionality.RESULTSWithin gliomas, T cells were localized in the infiltrating edge and perivascular space of tumors, while residing mostly in the stroma of metastatic tumors. CD163+ macrophages were evident throughout the TME of metastatic tumors, whereas in gliomas, CD68+, CD11c+CD68+, and CD11c+CD68+CD163+ …

Impact Of The Policy Environment On Substance Use Among Sexual Minority Women, Laurie A. Drabble, Cat Munroe, Amy A. Mericle, Sarah Zollweg, Karen F. Trocki, Katherine J. Karriker-Jaffe

Faculty Research, Scholarly, and Creative Activity

Background: Sexual minority women (SMW) are at greater risk for heavy episodic drinking, frequent marijuana use, and tobacco use than heterosexual women. Because past research has suggested the political and social environment may influence disparities in substance use by sexual orientation, this study examined associations of the U.S. state-level policy environment on substance use by SMW.

Methods: A total of 732 SMW participants were recruited from two national online panels: a general population panel (n = 333) and a sexual minority-specific panel (n = 399). Past year substance use was defined by number of days of heavy episodic drinking (HED; …

Fad Diets: Professional Development Needs Among Nutrition Agents In Select Southern States, Abigail P. Mcalister, Vicky L. Green, Simone Camel, Mary C. Fontenot, Janet F. Pope

Journal of Extension

Because FCS agents teach communities about dietary guidelines, it is important that they are aware of the latest nutrition research. This study assessed FCS agents’ knowledge of popular fad diets (low-carbohydrate, intermittent fasting, detoxes and cleanses) and their potential adverse effects, and its relationship among location, certifications, years of experience, professional association memberships, and education. Agents in Louisiana, Texas, Arkansas, and Mississippi were emailed a survey. RDN, DTR, and CHES certifications had significant associations (p = 0.03) with knowledge of adverse effects of fad diets. Agents who hold these credentials may have more knowledge about adverse effects of fad diets.

Factors Affecting Emergency Department Mental Health Visits, Logan Daul

Honors Thesis

Research has shown that current quantities of emergency department visits for mental health and substance use are increasing at a startling rate. These increases are acknowledged in quantitative studies and some important information can be gathered from qualitative studies however determining specific causes for these emergent visits are difficult. The purpose of this study is to derive findings from statistical analyses focusing on quantities of emergency department visits for mental health and substance use disorders. Comparisons will be drawn at the state level between the per capita quantity of emergency department visits and poverty rate, climate, psychiatric healthcare infrastructure, urban …

Eight Tips For The Implementation Of The First Licenced Peanut Allergy Oral Immunotherapy Into Clinical Practice., Jay M. Portnoy, Christina E. Ciaccio, Janet Beausoleil, George Du Toit, Stanley Fineman, Stephen A. Tilles, June Zhang, Claire Lawrence, Mohamed Yassine, S Shahzad Mustafa

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Shared learnings from the early use of novel therapies can aid in their optimization. The recent introduction of peanut oral immunotherapy (peanut OIT; Palforzia [Peanut (Arachis hypogaea) Allergen Powder-dnfp]) for peanut allergy addresses a significant unmet need but also highlights the requirement for consideration of several factors by both prescribers and patients.

OBJECTIVE: To provide guidance for prescribers of licenced peanut OIT to facilitate treatment delivery and improve outcomes.

METHODS: Clinicians with experience of licenced peanut OIT (United States n = 6, United Kingdom n = 1) participated in a series of interviews and group discussions designed to elicit …

Comparison Of Hemodynamic Responses Between Conventional And Virtual Reality Therapies In Patients With Heart Failure Admitted To An Emergency Room, Angélica Bologna Raposo, Alice Haniuda Moliterno, João Pedro Lucas Neves Silva, Rafael Varago Favri, Ana Paula Coelho Figueira Freire, Francis Lopes Pacagnelli

All Faculty Scholarship for the College of Education and Professional Studies

This study aimed to evaluate and to compare the acute response, due to semi-immersive virtual reality (VR) and conventional therapies (CT), of hemodynamic parameters in hospitalized individuals admitted to an emergency unity for heart failure (HF). This is a viability study with 11 individuals subjected to sessions with and without VR. At CT, stretching, active or active-assisted exercises, and fractional inspiration were performed. In VR therapy (VRT), VR box glasses were used to promote VR relaxation associated with CT. The hemodynamic parameters evaluated were heart rate, systolic and diastolic blood pressure, oxygen saturation, and double product. To analyze them, Student’s …

Understanding The Transport And Chemistry Of Indoor Air During Wildfire Smoke Events With Elliott Gall, Elliott T. Gall

PDXPLORES Podcast

Dr. Elliott Gall, Associate Professor in the Mechanical and Materials Engineering Department at Portland State University, studies indoor air quality in order to better understand how to improve building designs to promote health.

Wildfires are increasing in frequency and intensity. So, too, are wildfire smoke events. Smoke from wildfires pose serious health risks. That is why the Environmental Protection Agency recommends individuals remain indoors during smoke events.

In this episode, Professor Gall discusses the importance of understanding the chemistry of wildfire smoke indoors and how smoke is transported into buildings.

Click on the "Download" button to access the audio transcript.

Effectiveness Of Short-Term Heat Acclimation On Intermittent Sprint Performance In The Heat With Moderately Trained Males, Andrew T. Garrett, Matt Birkett, Damien O. Gleadall-Siddall, Rachel Burke, James Bray, Fiona Nation

Journal of Human Performance in Extreme Environments

Purpose: Effectiveness of short-term heat acclimation (STHA), over 5-days (permissive dehydration), on intermittent heat stress test (HST) with males. Methods: Ten, moderately-trained, males (mean [SD]; age 25.6 [8.9] y; stature 180.7 [5.6] cm; body mass 83.2 [10.8] kg; and 45.3 [6.5] mL^.kg^-1.min^-1) participated. The HST was 9 x 5min (45-min) of intermittent exercise based on professional soccer players. One week apart, HST1 vs HST (11.0°C; 50%RH), as a reliability trial and HST3 in 31.0°C; 50%RH were completed. Then 90 min dehydration, STHA (no fluid intake), for 5 consecutive days (39.5^oC; 60%RH), using …

Intouch May 9, 2022, New York Medical College

InTouch

• Yom Hashoah Symposium Analyzed the Impact of Nuremberg Trials
• Chair of Radiation Medicine, Mark Hurwitz, M.D., Receives Prestigious Award from Society of Thermal Medicine
• NYMC Researchers Find That Probiotics Can be Used to Treat Severe Gum Disease
• Convocation of Thanks Offers Opportunity for Students to Honor “First Patients”
• Alpha Omega Alpha Iota Chapter Recognizes Academic Excellence at 2022 Induction Ceremony
• SOM Celebrates Gold Humanism Honor Society Class of 2023 Induction
• Ph.D. Candidate Catherine D’Addario Finds Fulfillment in the Lab

General Variability Leads To Specific Adaptation Toward Energy Optimal Policies, Sabrina J. Abram, Katherine L. Poggensee, Natalia Sánchez, Surabhi N. Simha, James M. Finley, Steven H. Collins, J. Maxwell Donelan

Physical Therapy Faculty Articles and Research

Our nervous systems can learn optimal control policies in response to changes to our bodies, tasks, and movement contexts. For example, humans can learn to adapt their control policy in walking contexts where the energy-optimal policy is shifted along variables such as step frequency or step width. However, it is unclear how the nervous system determines which ways to adapt its control policy. Here, we asked how human participants explore through variations in their control policy to identify more optimal policies in new contexts. We created new contexts using exoskeletons that apply assistive torques to each ankle at each walking …

Bi-Order Multimodal Integration Of Single-Cell Data, Jinzhuang Dou, Shaoheng Liang, Vakul Mohanty, Qi Miao, Yuefan Huang, Xuesen Cheng, Jongsu Choi, Yumei Li, Li Li, May Daher, Rafet Basar, Katayoun Rezvani, Rui Chen, Ken Chen

Faculty, Staff and Student Publications

Integration of single-cell multiomics profiles generated by different single-cell technologies from the same biological sample is still challenging. Previous approaches based on shared features have only provided approximate solutions. Here, we present a novel mathematical solution named bi-order canonical correlation analysis (bi-CCA), which extends the widely used CCA approach to iteratively align the rows and the columns between data matrices. Bi-CCA is generally applicable to combinations of any two single-cell modalities. Validations using co-assayed ground truth data and application to a CAR-NK study and a fetal muscle atlas demonstrate its capability in generating accurate multimodal co-embeddings and discovering cellular identity.

Racial And Ethnic Differences In Genomic Profiling Of Early Onset Colorectal Cancer, David M Hein, Weiye Deng, Marylena Bleile, Syed Ali Kazmi, Brooke Rhead, Amy L Jones, Wen Jiang, Brandi Cantarel, Nina N Sanford

Faculty, Staff and Student Publications

The incidence and mortality of early onset colorectal cancer (EOCRC) is rising; outcomes appear to differ by race and ethnicity. We aimed to assess differences in mutational landscape and gene expression of EOCRC by racial and ethnic groups (non-Hispanic Asian, non-Hispanic Black, non-Hispanic White, White Hispanic) using data from the American Association for Cancer Research Project GENIE (10.2) and University of Texas Southwestern, the latter enriched in Hispanic patients. All statistical tests were 2-sided. Of 1752 EOCRC patients, non-Hispanic Black patients had higher rates of KRAS mutations (60.9%; P = .001, q = 0.015), and non-Hispanic White and non-Hispanic Black …

Central Nervous System Immune Interactome Is A Function Of Cancer Lineage, Tumor Microenvironment, And Stat3 Expression, Hinda Najem, Martina Ott, Cynthia Kassab, Arvind Rao, Ganesh Rao, Adam M Sonabend, Roel Verhaak, Anand Shankar, Santhoshi N Krishnan, Frederick S Varn, Víctor A Arrieta, Pravesh Gupta, Sherise D Ferguson, Jason T Huse, Gregory N Fuller, James P Long, Daniel E Winkowski, Ben A Freiberg, Charles David James, Leonidas C Platanias, Maciej S Lesniak, Jared K Burks, Amy B Heimberger

Faculty, Staff and Student Publications

BACKGROUND

Immune cell profiling of primary and metastatic CNS tumors has been focused on the tumor, not the tumor microenvironment (TME), or has been analyzed via biopsies.

METHODS

En bloc resections of gliomas (n = 10) and lung metastases (n = 10) were analyzed via tissue segmentation and high-dimension Opal 7-color multiplex imaging. Single-cell RNA analyses were used to infer immune cell functionality.

RESULTS

Within gliomas, T cells were localized in the infiltrating edge and perivascular space of tumors, while residing mostly in the stroma of metastatic tumors. CD163⁺ macrophages were evident throughout the TME of metastatic …

Characterization Of Retinal Function And Structure In The Mptp Murine Model Of Parkinson's Diseasecharacterization Of Retinal Function And Structure In The Mptp Murine Model Of Parkinson’S Disease, Anh Hoang

Faculty, Staff and Student Publications

In addition to well characterized motor symptoms, visual disturbances are increasingly recognized as an early manifestation in Parkinson's disease (PD). A better understanding of the mechanisms underlying these changes would facilitate the development of vision tests which can be used as preclinical biomarkers to support the development of novel therapeutics for PD. This study aims to characterize the retinal phenotype of a mouse model of dopaminergic dysfunction and to examine whether these changes are reversible with levodopa treatment. We use a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD to characterize the neurotoxic effects of MPTP on in vivo retinal function (electroretinography, …

Pattern Differentiation And Tuning Shift In Human Sensory Cortex Underlie Long-Term Threat Memory

Faculty, Staff and Student Publications

The amygdala-prefrontal-cortex circuit has long occupied the center of the threat system 1, but new evidence has rapidly amassed to implicate threat processing outside this canonical circuit 2-4. Through non-human research, the sensory cortex has emerged as a critical substrate for long-term threat memory 5-9, underpinned by sensory cortical pattern separation/completion 10,11 and tuning shift 12,13. In humans, research has begun to associate the human sensory cortex with long-term threat memory 14,15, but the lack of mechanistic insights obscures a direct linkage. Towards that end, …

2022-05-08_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus/stats/coronavirus-symptoms. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated twice a week on Mondays and Thursdays.

Syndromic Surveillance System data is obtained from approximately 216 facilities participating in syndromic surveillance (139 Emergency Departments (ED), 77 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, …