Medicine and Health Sciences Commons^™

Screening And Characterization Of A Pan-Gtpase Inhibitor, Leyla Akhadov

Biomedical Engineering ETDs

Abnormal functioning of small GTPases is implicated in a variety of diseases, ranging from neurological and developmental diseases to cancer. In fact, mutant GTPases are found in up to 30% of cancers. Thus, small GTPases are a highly relevant target in drug discovery and development. High-throughput targeted screening of small molecules is the most productive method of discovering compounds that can give insights into drug development. This thesis describes improvements made to a high-throughput GTPase-targeted screening method to minimize confounding systematic error. It also describes the follow-up characterization of a compound that was identified in a high-throughput screen. The compound …

2020-05-15 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Lori D. Sloane, Anastasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Ryen Ormesher, Melissa Cossé, Timothy Campbell, Jenny Situ, Randy Ko, Ariel Hurwitz, Alexandra Yingling, Perez Olewe, Tudor I. Oprea, Cristian Bologa, Gregory Mertz, Kristine Tollestrup, Orrin Myers, Douglas J. Perkins

HSC Covid 19 Briefings

Executive Summary:

Governor clarifies health orders. NM childhood deaths high. NM workplace investigations. NM case count. Navajo emergency orders. $77M NM testing/tracing. NM convalescent plasma. NM unemployment claims slow. NM food bank challenges. Farmington Mall protest. $3T bill opposition. Lancet FDA revival call. UK Roche antibody testing. Swedish excess mortality. End of Slovenia pandemic. US invest in COVID-19 vaccine. Safe decontamination N95 respirators. Business occupancy load. 10 years of life lost burden. Forecasting models predict deaths. Infection fatality rate 8%. Resilient medical education. Restrictions: human rights law. Guidelines for nursing homes. Managing hematology and oncology patients. Abbott test accuracy. Lab …

The Effectiveness Of Visual Phonics To Promote Phonological Awareness In Preschool Children With And Without Speech Sound Delays, Katelyn Derby

Dissertations, Theses, and Projects

The purpose of this study was to examine the phonological awareness skill of letter-sound relationships for preschool students using the multi-kinesthetic Visual Phonics intervention, See the Sound/Visual Phonics. The study had a non-concurrent multiple baseline data procedure, where each child was exposed to a general phonics curriculum in comparison to a Visual Phonics intervention. A specific interest was understanding potential benefits (i.e., rate of mastery) for preschool students with typical hearing, and the potential for Visual Phonics to support improved letter-sound accuracy for children at risk for speech sound disorders and delays. The results of the study indicated See the …

Patient And Facility Perceptions On The Feasibility Of A Student-Run Pro-Bono Back-School For Uninsured Patients With Low Back Pain, Javier Ascanio-Pellon, Sofia Cruz, Lauren Liebert, Trevor Pacuk

UNLV Theses, Dissertations, Professional Papers, and Capstones

A. Background of Knowledge: Nevada ranks 8th highest in uninsured population in the United States. People who are uninsured may be more affected by low back pain (LBP) than their insured counterparts. Volunteers in Medicine of Southern Nevada (VMSN), a non-profit organization, serves uninsured people in Nevada. VMSN partnered with UNLV Physical Therapy (UNLVPT) to provide a back-school for patients. UNLVPT proposed a service-learning model to provide both education and treatment for VMSN patients with LBP. B. Purpose: The purpose of this community-based research project is to create and implement a student-run pro-bono back-school for uninsured individuals with LBP in …

Orthostatic Blood Pressure And Arterial Stiffness In Persons With Spinal Cord Injury: The Effect Of The Renin Angiotensin Aldosterone System, Caitlyn G. Katzelnick

Seton Hall University Dissertations and Theses (ETDs)

With advances in acute medical care, longevity has increased in persons with SCI; however, morbidity due to cardiovascular disease (CVD) occurs at an earlier age compared to the general population. Arterial stiffness (AS) is recognized as an independent risk factor for CVD and, specifically, pulse wave velocity (PWV) has been proven to be a valid tool to predict and track structural arterial changes that reflect arteriosclerosis. Evidence has shown that persons with SCI have increased AS compared to uninjured able-bodied controls; however, possible contributors to this increase are not yet fully understood. After a SCI, sympathetic control in the regions …

Allosteric Inhibitor Of Β-Catenin Selectively Targets Oncogenic Wnt Signaling In Colon Cancer., Anton Cheltsov, Natsuko Nomura, Venkata Mahidhar Yenugonda, Jatin Roper, Rajesh Mukthavaram, Pengfei Jiang, Nam-Gu Her, Ivan Babic, Santosh Kesari, Elmar Nurmemmedov

Articles, Abstracts, and Reports

Abnormal regulation of β-catenin initiates an oncogenic program that serves as a main driver of many cancers. Albeit challenging, β-catenin is an attractive drug target due to its role in maintenance of cancer stem cells and potential to eliminate cancer relapse. We have identified C2, a novel β-catenin inhibitor, which is a small molecule that binds to a novel allosteric site on the surface of β-catenin. C2 selectively inhibits β-catenin, lowers its cellular load and significantly reduces viability of β-catenin-driven cancer cells. Through direct binding to β-catenin, C2 renders the target inactive that eventually activates proteasome system for its removal. …

Black Pregnancy Matters: Racial Reproductive Bias In African American Maternal Mortality, Juhi Khemani

Master's Projects and Capstones

This semester-long research project uncovers how racial biases demonstrated in the reproductive health field, and specifically before, during, and after childbirth, affect the rate of maternal mortality and morbidity for African American mothers in the United States. The rate of maternal mortality for this specific racial group is four times greater as compared to Caucasian women and this discrepancy will be investigated and analyzed throughout this capstone thesis. Interviews were conducted with key figures in the obstetric and gynecological field as well as with Black mothers themselves in an effort to uncover what factors, aside from medical anomalies, are leading …

Brain Volumes And Dual-Task Performance Correlates Among Individuals With Cognitive Impairment: A Retrospective Analysis, Jon Basterrechea, Daniel Krist, Caitlin Moreland, Morgan Wise

UNLV Theses, Dissertations, Professional Papers, and Capstones

Background: Cognitive impairment (CI) is a prevalent condition characterized by loss of brain volume and changes in cognition, motor function, and dual-tasking ability. Objective: To examine associations between brain volumes, dual task performance, and gait and balance in those with CI to elucidate the mechanisms underlying loss of function. Methods: We performed a retrospective analysis of medical records of patients with CI and compared brain volumes, dual task performance, and measures of gait and balance. Results: Greater cognitive function and combined dual task effect (DTE) is associated with smaller brain volumes. In contrast, greater motor DTE is associated with larger …

Comparisons Of Patellar Bone Mineral Density Between Individuals With And Without Patellofemoral Pain, Chris Khuu, Allina Cummins, Steven Shepherd

UNLV Theses, Dissertations, Professional Papers, and Capstones

Background: Although bone stress injuries have been reported in individuals with patellofemoral pain (PFP), especially within the lateral patella, it remains unclear whether persons with PFP exhibit altered patellar regional bone mineral density (BMD). The primary purpose of this study was to compare BMD of the patella (lateral, medial, and total regions) between individuals with and without PFP using quantitative computed tomography (QCT). The secondary aim was to examine the associations between patellar regional BMD and patellofemoral joint (PFJ) alignment. Methods: Ten individuals with retropatellar pain and 10 sex, age, weight, height, and activity matched pain-free controls underwent a QCT …

Expanding Qualitative Research Interviewing Strategies: Zoom Video Communications, Lisa M. Gray, Gina Wong-Wylie, Gwen R. Rempel, Karen Cook

The Qualitative Report

The proliferation of new video conferencing tools offers unique data generation opportunities for qualitative researchers. While in-person interviews were the mainstay of data generation in qualitative studies, video conferencing programs, such as Zoom Video Communications Inc. (Zoom), provide researchers with a cost-effective and convenient alternative to in-person interviews. The uses and advantages of face-to-face interviewing are well documented; however, utilizing video conferencing as a method of data generation has not been well examined. The purpose of this paper is to examine the specific attributes of Zoom that contribute to high quality and in-depth qualitative interviews when in person interviewing is …

Anticipatory Threat Responding: Associations With Anxiety, Development, And Brain Structure, Rany Abend, Andrea L. Gold, Jennifer C. Britton, Kalina J. Michalska, Tomer Shechner, Jessica F. Sachs, Anderson M. Winkler, Ellen Leibenluft

School of Medicine Publications

BACKGROUND: While translational theories link neurodevelopmental changes in threat learning to pathological anxiety, findings from studies in patients inconsistently support these theories. This inconsistency may reflect difficulties in studying large patient samples with wide age ranges using consistent methods. A dearth of imaging data in patients further limits translational advances. We address these gaps through a psychophysiology and structural brain imaging study in a large sample of patients across the lifespan.

METHODS: A total of 351 participants (8-50 years of age; 209 female subjects; 195 healthy participants and 156 medication-free, treatment-seeking patients with anxiety) completed a differential threat conditioning and …

Transdiagnostic Multimodal Neural Correlates Of Psychosis Dimensions, Dov Bernard Lerman-Sinkoff

McKelvey School of Engineering Graduate Student Theses & Dissertations

Psychosis refers to a debilitating set of symptoms that impacts individuals, their communities, and society at large. Current psychiatric nosology treats psychosis as a categorical construct. However, recent evidence suggests that a dimensional approach that cuts across extant nosological boundaries may more accurately represent the underlying phenomena contributing to dysfunction in psychosis. One putative domain of transdiagnostic variation is cognitive control, a construct that refers to the set of functions that enable and support goal-directed behavior and regulation of one’s thoughts and actions. Previous analyses in both healthy individuals and individuals with psychosis have led to a number of findings …

A Public Health Examination Of The Discipline Gap, Karishma Furtado

Arts & Sciences Graduate Student Theses and Dissertations

Education is often positioned as the great equalizer in the United Statesѡ cure all for many social ills, from poverty, to family instability, to exposure to violence. However, disadvantaged students tend, on average, to get a lower quality education. One example of a barrier that impedes educational equity is the discipline gap, or the disproportionate rate of exclusionary discipline like suspension and expulsion experienced by students with disabilities and those from historically disadvantaged racial, ethnic, and gender subgroups. Removing a student from class for punitive reasons puts them at greater risk of academic disengagement, a diminished sense of belonging and …

Pillars Of The Nutrition Transition: The Global Impacts Of Ultra-Processed Foods And Beverages On Overweight And Obesity And National Nutrient Supplies, Jacob Eaton

Arts & Sciences Graduate Student Theses and Dissertations

Malnutrition in some form impacts nearly one-third of the global population. Across the world, countries are undergoing the Үutrition transitionӠfrom traditional and largely unprocessed diets to Western-style, energy-dense diets. At the same time, rates of overweight and obesity and diet-related chronic diseases continue to climb. Ultra-processed foods (UPF), sugar-sweetened beverages (SSB), and vegetable oils are three of the foods driving the nutrition transition. This dissertation calculates changes in the global food supply between 1961 and 2013 and quantifies the influence of UPF and SSB (as measured through sales) on national nutrient supplies between 2005 and 2013 and trends in adult …

Expressive Vocabulary Development In Very Young Children Who Are Deaf Or Hard Of Hearing, Amanda Mcnamara Rudge

Arts & Sciences Graduate Student Theses and Dissertations

This longitudinal study aimed to explore the expressive vocabulary growth rate of children ages birth to three years, who are deaf or hard of hearing (d/hh). An additional aim was to investigate hours of direct instruction received during early intervention as a factor that may contribute to the trajectories of expressive vocabulary growth in young children who are d/hh. Hierarchical linear modeling with growth curve analysis was used to investigate expressive vocabulary growth in a population of d/hh children using multiple points of longitudinal vocabulary data. A total of 417 assessments across the 105 participants were analyzed to determine the …

Atrioventricular Nodal Reentrant Tachycardia In Patients With Complex Congenital Heart Disease And Twin Atrioventricular Nodes., John Papagiannis, Christopher Mathis, Lindsey Malloy-Walton, Svjetlana Tisma-Dupanovic

Manuscripts, Articles, Book Chapters and Other Papers

No abstract provided.

Healing Lgbtq+ Juvenile Youth Of Color Through Indigenous Practices, Jennifer Alvarez

Master's Theses

My goal for this study was to explore the experiences of queer youth of color who have been in the juvenile justice system in relation to their mental health/wellness. Through semistructured interviews, the seven participants of this study have shared their testimonio of coming out, being involved in the juvenile justice system and having to engage with mental health services, I explore how queer individuals are mistreated and are placed on temporary methods of healing from their trauma. Utilizing the frameworks of Testimonios, Critical Race Theory and Critical Pedagogy, I bring forward the experiences that queer youth of color in …

A Battle For Hope, Kaline E. Mulvihill

Akesis

I have friends and family members working in all aspects of the medical system. They are PAs, PTs, nurses, doctors, caregivers, and support staff. They are on the frontline in the brutal battle against Covid-19. This is their story. It is a story about fear, duty, strength, and finding hope. While we adapt to this new normal and cope with the ever-changing landscape, we have to remember that we are all in this fight together.

No Sneezing In Public, Anonymous Author

Akesis

Poetry relating to compassion during COVID-19 pandemic

Broken With Nature, Meghan Bowler

Akesis

This is a short reflection on two separate periods of intense mental and physical self-healing. Nature removed me from the imprisonment of my own mind around 8 years ago, only to fall back into its grips after a recent hip surgery. Hiking/physical activity was the only form of therapy that I was vulnerable enough to let heal me. It would break me down mentally and physically while rebuilding me at the same time. Some information was derived from personal journal entries but all are very relevant to each and every hike I take today.

Tides, Paul S. Eo

Akesis

This photo is an overhead shot of the waves breaking at Pine Point beach. This represents so much for me. In these times of uncertainty it gives me hope that the tides will eventually turn. And just like the tides, this too will take a turn for the better. It also represents the healing and cleansing qualities of the sea.

Motus Habitus: An Anatomical Ethnography, Michael Cyr, Jordan G. Lamb

Akesis

Although this project began long before the release of Akesis' Spring theme, it perfectly encapsulates adaptation in many ways. The response to the recent pandemic and the disruption to people's daily routines has caused us to reflect on the ways we experience our bodies and minds in the absence of work, recreation, sociality, and movement. Movement, a key to human health and happiness, has been greatly restrained as most of us are confined to our living quarters. Now more than ever it is important to acknowledge the effects of lifestyle on body and health and find creative ways to move …

Decision 2020, Rolene Yousefyan

Akesis

The materials used to create this piece were chalk pastels. The inspiration behind this drawing was the difficult decisions we all have had to make at some point throughout our lives. No matter the reason why we made these decisions, there is no changing them and they may forever change the pathways of our lives.

Photographic Validation Of Target Versus Nontarget Take Of Brown Treesnake Baits, Shane R. Siers, Aaron B. Shiels, Cynthia G. Payne, Francinem M. Chlarson, Craig S. Clark, Stephen M. Mosher

United States Department of Agriculture Wildlife Services: Staff Publications

Use of toxic baits or other tools for managing nuisance species must ensure that the species of interest is adequately targeted while exposure to nontarget species is minimized. Nontarget takes of acetaminophen‐laced baits for control of invasive brown treesnakes (Boiga irregularis) on Guam may put those animals at risk of lethal intoxication and render the bait unavailable to the intended target species. We used wildlife cameras to identify species removing toxic and nontoxic baits from brown treesnake bait stations designed to exclude nontarget taxa in 2015 and 2016. Throughout various sites and habitat types, and balanced by season (wet vs. …

Time Allocation To Resources By Three Species Of Rats (Rattus Spp.) In A Radial Arm Maze, Gary Witmer, Nathan P. Snow, Rachael S. Moulton

United States Department of Agriculture Wildlife Services: Staff Publications

Context. Introduced rats (Rattus spp.) can pose a serious threat to native flora and fauna, especially on islands where most species have evolved in the absence of terrestrial predators. Effective detection and eradication methods for introduced rats are essential to the maintenance of insular ecosystem integrity. Thus, it is important to better understand the behaviour of rats when they first arrive in a new setting.

Aims. To determine whether rats would find some novel stimuli to be significantly more attractive than other novel stimuli.

Methods. An eight-arm radial maze was used to study the behaviour of three species of Rattus …

Interactions With Humans Shape Coyote Responses To Hazing, Julie K. Young, Edd Hammill, Stewart W. Breck

United States Department of Agriculture Wildlife Services: Staff Publications

Medium and large carnivores coexist with people in urban areas globally, occasionally resulting in

negative interactions that prompt questions about how to reduce human-wildlife conflict. Hazing,

i.e., scaring wildlife, is frequently promoted as an important non-lethal means for urbanites to reduce

conflict but there is limited scientific evidence for its efficacy. We used a population of captive coyotes (Canis latrans) to simulate urban human-coyote interactions and subsequent effects of hazing on coyote behavior. Past experiences with humans significantly affected the number of times a coyoteapproached a human to necessitate hazing. coyotes that had been hand fed by adults had to …

Hawaii As A Microcosm: Advancing The Science And Practice Of Managing Introduced And Invasive Species, Liba Pejchar, Christopher A. Lepczyk, Jean E. Fantle-Lepczyk, Steven C. Hess, M. Tracy Johnson, Christina R. Leopold, Michael Marchetti, Katherine M. Mcclure, Aaron B. Shiels

United States Department of Agriculture Wildlife Services: Staff Publications

Invasive species are a leading driver of global change, with consequences for biodiversity and society. Because of extraordinary rates of endemism, introduction, and extinction, Hawaii offers a rich platform for exploring the cross-disciplinary challenges of managing invasive species in a dynamic world. We highlight key successes and shortcomings to share lessons learned and inspire innovation and action in and beyond the archipelago. We then discuss thematic challenges and opportunities of broad relevance to invaded ecosystems and human communities. Important research needs and possible actions include eradicating mammals from mainland island sanctuaries, assessing hidden threats from poorly known introduced species, harnessing …

Deciphering Interactions Between White-Tailed Deer And Approaching Vehicle, Morgan Pfeiffer, Raymond B. Iglay, Thomas W. Seamans, Bradley F. Blackwell, Travis L. Devault

United States Department of Agriculture Wildlife Services: Staff Publications

Deer-vehicle collisions are a major transportation hazard, but factors affecting deer escape decision-making in response to vehicle approach remain poorly characterized. We made opportunistic observations of deer response to vehicle approach during daylight hours on a restricted- access facility in Ohio, USA (vehicle speeds were ≤64 km/h). We hypothesized that animal proximity to the road, group size, vehicle approach, and ambient conditions would affect perceived risk by white-tailed deer (Odocoileus virginianus) to vehicle approach, as measured by flight-initiation distance (FID). We constructed a priori models for FID, as well as road-crossing behavior. Deer responses were variable and did not demonstrate …

Provider Education And Rapid Antigen Detection Test Use In Private And Academic Pediatric Clinics, Steven Dahl

Research Days

No abstract provided.

Neurally Adjusted Ventilatory Assist In Neonates With Congenital Diaphragmatic Hernia, Yonatan Kurland

Research Days

No abstract provided.