Medicine and Health Sciences Commons^™

Frequency Of Limited English Proficient (Lep) Patient Visits And Language Resources: An Assessment Of Rural Oregon's Health Centers And Working With Lep Communities, Gabriel I. Lehrburger

University Honors Theses

Persons with limited English proficiency (LEP) can face barriers when seeking health care. Rural communities often have reduced access to some health resources. However, little is known about how rural communities meet the language needs of their LEP populations. A cross-sectional survey and interview were designed and sent to managerial staff in rural health centers around the state of Oregon. During the months of January – March 2020, survey and interview data were collected to assess the relationship between frequency of LEP patient visits and available language resources in rural Oregon. The study also investigated staff perceptions when working with …

Expansion Of Medication Therapy Management Services To Rural Sites For Patients With An Employer-Sponsored Health Plan, Taylor Thooft Pharmd

Theses and Dissertations

Previous literature supports that pharmaceutical care provider in the ambulatory care setting can improve clinical, economic, and humanistic outcomes for recipients, and when utilized in employer-provided health plans can lead to reduced spending on healthcare costs by employers. A large health system in central Minnesota offers an Employee Medication Therapy Management (MTM) benefit that offers further financial incentives to meet with an MTM Pharmacist for a comprehensive review of one’s medications. Currently, this program is underutilized due to both lack of awareness of the program and geographic for employees in the wester region of the health system. This project sought …

Effectiveness Of Splinting In Adults With Radial Nerve Palsy, Laurel Jeanette Pitman, Logan Buckner, Logan Stem, Sarah Grace Rogers, Emylee Williams

Master of Occupational Therapy Student Critically Appraised Topics

The final portfolio contains 5 research articles from national and international journals. The study designs included in this portfolio are one small-scale RTC, one retrospective pretest posttest design, and three case studies. The studies included help answer our PICO question and help draw conclusions about how to care for adults with radial nerve palsy in regards to splinting. Three of the articles compared static splinting and dynamic splinting in regards to improvements in hand function. Two of the articles focused on dynamic splinting as a means of treatment for adults with radial nerve palsy.

2020-05-20_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

2020-05-20_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

The webpage was obtained from Michigan's Coronavirus Cumulative Data page, under the link Data About Places. Data is self-reported by hospitals daily to the EM Resource System per MDHHS Director Robert Gordon's Emergency Order.

Contains the tables Statewide Available Bed Tracking for COVID-19, COVID-19 Metrics, Statewide Available PPE Tracking for COVID-19 (Statewide Available PPE and Bed Tracking), as well as the tables PPE Days On Hand and Patient Census.

Ua94/6/1 My Story: Wku Football's Malik Staples, Malik Staples

Student/Alumni Personal Papers

My Story is a series of first-person feature articles written by WKU student-athletes. The student-athletes will be telling their own stories in their own words. This article written by football graduate senior Malik Staples, who – along with his teammates – has navigated through a different type of Spring Ball over the past two months.

2020-05-20_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., with COVID-19 results included as of 10 a.m.

Note on cumulative counts: This report is provisional and subject to change. As public health investigations of individual cases continue, there will be corrections to the status and details of referred cases that result in changes to this report.
Note on the deaths: Deaths must be reported by health care providers, medical examiners/coroners, and recorded by local health departments …

2020-05-20_Michiganoverview_Covidcounts, Michigan Department Of Health & Human Services

Michigan COVID-19 Confirmed Cases by Date of Onset Data

Data was captured from the Cumulative Data link of Michigan's Coronavirus webpage, under the url https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173_99207---,00.html.

The website contained the table Count of Confirmed COVID-19 Cases by Date of Onset , sorted by Michigan Preparedness Region. It also contained 18 charts, including the count of confirmed Covid-19 cases by date of onset in the state overall as well as in each preparedness region,and the normalized rate of Covid-19 cases per 1,000,000 residents in both the state and in each preparedness region.

A Quality Improvement Pilot To Reduce Caregiver Burden In Caregivers Of Hematopoietic Stem Cell Transplant (Hsct) Patients In A Hsct Program In The Northwest, Jody Acheson

Doctor of Nursing Practice Projects

Background: Hematopoietic stem cell transplant (HSCT) is an intensive and complex treatment for certain blood cancers. Caregivers are required for patients receiving this treatment. Caregivers frequently experience caregiver burden. Providing an intervention to alleviate caregiver burden can positively impact patient and caregiver health outcomes.

Project Design: The following was the project design: 1) review the literature to understand the best practices to prevent caregiver burden for caregivers of patients undergoing HSCT, 2) development a pilot quality improvement program based on the evidence, 3) implementation of the pilot, and 4) obtaining feedback from facilitators and participants to optimize intervention for ongoing …

Kids Don’T Float…And Their Parents Don’T Either: Using A Family-Centered Approach In Alaska’S Kids Don’T Float Program, Michelle E. E. Bauer, Audrey R. Giles, Justina Marianayagam, Kelli M. Toth

International Journal of Aquatic Research and Education

The goal of this experiential report is to outline the adoption of a family-centered Kids Don’t Float approach. We conducted a critical synthesis of information to reflect the expansion of the Kids Don’t Float program into a more family-centered approach. The critical synthesis provided insights into why we should adopt this approach, how it was implemented, and how it influenced drowning incidents compared to the previously used child-centered approach. The adoption of a family-centered approach may contribute to reducing drowning incidents by targeting parents, providing safety information to families, and promoting parental modelling of life jackets. Program evaluators and water …

2020-05-20 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Mari Anixter, Anastasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Fiona Nguyen, Samantha Paltrow-Krulwich, Andrew Pierce, Stephen Esguerra, Allison Price, Randy Ko, Aly Raboff, Ariel Hurwitz, Alexandra Yingling, Elly Munde, Gregory Mertz, Orrin Myers, Douglas J. Perkins

HSC Covid 19 Briefings

Executive Summary:

NM Highlights: Governor’s update. NM case count. Governor’s response to republicans. Western Sky Community donation. Santa Feans using face coverings. NM Medicaid enrollment. NM colleges fall reopening. Rio Rancho partial reopening. NM Tourism Department cooking recipes. ABQ Meals on Wheels feeding more. US Highlights: Mexico influx California hospitals. Arkansas church outbreak. International Highlights: Estonia immunity passport rollout. South Korea school reopenings. Economics, Workforce, Supply Chain, PPE Highlights: Hydrogel patches for pressure injuries. Resuscitation with PPE. Journal of wound care PPE guidelines. Food supply chain protections. Epidemiology Highlights: Higher rates in Black communities. Superspreaders may explain propagation patterns. “Back-projection” …

2020-05-20 A Message From Chancellor Roth, Paul B. Roth

HSC Messages from the Chancellor

No abstract provided.

Correction To: Small Molecule Kras Agonist For Mutant Kras Cancer Therapy., Ke Xu, Dongkyoo Park, Andrew T Magis, Jun Zhang, Wei Zhou, Gabriel L Sica, Suresh S Ramalingam, Walter J Curran, Xingming Deng

Articles, Abstracts, and Reports

An amendment to this paper has been published and can be accessed via the original article.

Ccl2 Overexpression In The Brain Promotes Glial Activation And Accelerates Tau Pathology In A Mouse Model Of Tauopathy, Aurelie Joly-Amado, Jordan Hunter, Zainuddin Quadri, Frank Zamudio, Patricia V. Rocha-Rangel, Deanna Chan, Anisha Kesarwani, Kevin Nash, Daniel C. Lee, Dave Morgan, Marcia N. Gordon, Maj-Linda B. Selenica

Sanders-Brown Center on Aging Faculty Publications

Innate immune activation is a major contributor to Alzheimer’s Disease (AD) pathophysiology, although the mechanisms involved are poorly understood. Chemokine C-C motif ligand (CCL) 2 is produced by neurons and glial cells and is upregulated in the AD brain. Transgene expression of CCL2 in mouse models of amyloidosis produces microglia-induced amyloid β oligomerization, a strong indication of the role of these activation pathways in the amyloidogenic processes of AD. We have previously shown that CCL2 polarizes microglia in wild type mice. However, how CCL2 signaling contributes to tau pathogenesis remains unknown. To address this question, CCL2 was delivered via recombinant …

2020-05-20_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …

Ire1Α And Igf Signaling Predict Resistance To An Endoplasmic Reticulum Stress-Inducing Drug In Glioblastoma Cells., Jeffrey J Rodvold, Su Xian, Julia Nussbacher, Brian Tsui, T Cameron Waller, Stephen C Searles, Alyssa Lew, Pengfei Jiang, Ivan Babic, Natsuko Nomura, Jonathan H Lin, Santosh Kesari, Hannah Carter, Maurizio Zanetti

Articles, Abstracts, and Reports

To date current therapies of glioblastoma multiforme (GBM) are largely ineffective. The induction of apoptosis by an unresolvable unfolded protein response (UPR) represents a potential new therapeutic strategy. Here we tested 12ADT, a sarcoendoplasmic reticulum Ca2+ ATPase (SERCA) inhibitor, on a panel of unselected patient-derived neurosphere-forming cells and found that GBM cells can be distinguished into "responder" and "non-responder". By RNASeq analysis we found that the non-responder phenotype is significantly linked with the expression of UPR genes, and in particular ERN1 (IRE1) and ATF4. We also identified two additional genes selectively overexpressed among non-responders, IGFBP3 and IGFBP5. CRISPR-mediated deletion of …

Increasing Access To Medicare Annual Wellness Visits In Primary Care; Utilizing Registered Nurses As Part Of An Interdisciplinary Team Based Approach, Iyo Kubota

Doctor of Nursing Practice (DNP) Projects

Background: In order to provide evidence-based preventive care to the aging population, Medicare began providing free annual wellness visits (AWVs) to its beneficiaries in 2011. The AWVs are a great opportunity for primary care providers to develop personalized preventive care as well as health promotion. However, many primary care practices especially those with limited resources struggle to incorporate AWVs into their busy primary care practice. Centers for Medicare and Medicaid Services allows other providers than physicians, NPs and PAs to perform those visits including registered nurses, health educators, and registered dietitians.

Methods: A pilot project was conducted with 12 patients …

Objective Church Environment Audits And Attendee Perceptions Of Healthy Eating And Physical Activity Supports Within The Church Setting, Marilyn E. Wende, Andrew T. Kaczynski, John A. Bernhart, Caroline G. Dunn, Sarah Wilcox

Faculty Publications

Interventions in faith-based settings are increasingly popular, due to their effectiveness for improving attendee health outcomes and behaviors. Little past research has examined the important role of the church environment in individual-level outcomes using objective environmental audits. This study examined associations between the objectively measured physical church environment and attendees’ perceptions of physical activity (PA) and healthy eating (HE) supports within the church environment, self-efficacy for PA and HE, and self-reported PA and HE behaviors. Data were collected via church audits and church attendee surveys in 54 churches in a rural, medically underserved county in South Carolina. Multi-level regression was …

The Impact Of An Opioid Use Disorder Immersive Education Experience On Preprofessional Health Care Students’ Development Of Hope And Hopeful Communication (Dissertation), Kerri Green Ms, Edd

Department of Education

Currently, the prescription opioid and heroin overdose epidemic is the worst public health crisis in Pennsylvania and addiction problems within the Lehigh Valley far outpace the number of health professionals trained to provide care in the field of Addiction Medicine. Additionally, negative attitudes towards individuals with substance use disorder are prevalent among health care providers. Unfortunately, this trend may continue as preprofessional health care curricula across many disciplines still lack the social, emotional, and behavioral competencies to treat patients with substance use disorder. Lehigh Valley Health Network has been an integral community-based partner in addressing the multi-faceted disease of Opioid …

Brain Structure Changes Over Time In Normal And Mildly Impaired Aged Persons, Charles D. Smith, Linda J. Van Eldik, Gregory A. Jicha, Frederick A. Schmitt, Peter T. Nelson, Erin L. Abner, Richard J. Kryscio, Richard R. Murphy, Anders H. Andersen

Neurology Faculty Publications

Structural brain changes in aging are known to occur even in the absence of dementia, but the magnitudes and regions involved vary between studies. To further characterize these changes, we analyzed paired MRI images acquired with identical protocols and scanner over a median 5.8-year interval. The normal study group comprised 78 elders (25M 53F, baseline age range 70-78 years) who underwent an annual standardized expert assessment of cognition and health and who maintained normal cognition for the duration of the study. We found a longitudinal grey matter (GM) loss rate of 2.56 ± 0.07 ml/year (0.20 ± 0.04%/year) and a …

Factors Impacting Swimming Participation And Competence: A Qualitative Report, Todd E. Layne, Carol C. Irwin, Jennifer Renee Pharr, Richard L. Irwin

International Journal of Aquatic Research and Education

Drowning continues to be a major cause of death for children, especially among minority groups. USA Swimming commissioned studies in 2008 and 2010 to look at swimming ability or inability, an associated drowning variable. The 2010 study showed alarming high percentages regarding insufficient swimming skill for many demographic groups. The current study’s purpose was to provide further analysis of variables which emerged from 2010 study and how these variables are affecting all US populations. Focus group interviews accomplished in three regionally diverse US cities asked participants (3=fathers; 12=mothers) about their personal history with swimming, perceptions concerning swimming in general, and …

Table Of Contents

Journal of the South Carolina Academy of Science

No abstract provided.

An Elvitegravir Nanoformulation Crosses The Blood–Brain Barrier And Suppresses Hiv-1 Replication In Microglia, Yuqing Gong, Kaining Zhi, Prashanth K.B. Nagesh, Namita Sinha, Pallabita Chowdhury, Hao Chen, Santhi Gorantla, Murali M. Yallapu, Santosh Kumar

School of Medicine Publications

Even with an efficient combination of antiretroviral therapy (ART), which significantly decreases viral load in human immunodeficiency virus type 1 (HIV-1)-positive individuals, the occurrence of HIV-1-associated neurocognitive disorders (HAND) still exists. Microglia have been shown to have a significant role in HIV-1 replication in the brain and in subsequent HAND pathogenesis. However, due to the limited ability of ART drugs to cross the blood–brain barrier (BBB) after systemic administration, in addition to efflux transporter expression on microglia, the efficacy of ART drugs for viral suppression in microglia is suboptimal. Previously, we developed novel poly (lactic-co-glycolic acid) (PLGA)-based elvitegravir nanoparticles (PLGA-EVG …

Global Kidney Exchange Should Expand Wisely., Alvin E Roth, Ignazio R. Marino, Obi Ekwenna, Ty B Dunn, Siegfredo R Paloyo, Miguel Tan, Ricardo Correa-Rotter, Christian S Kuhr, Christopher L Marsh, Jorge Ortiz, Giuliano Testa, Puneet Sindhwani, Dorry L Segev, Jeffrey Rogers, Jeffrey D Punch, Rachel C Forbes, Michael A Zimmerman, Matthew J Ellis, Aparna Rege, Laura Basagoitia, Kimberly D Krawiec, Michael A Rees

Department of Surgery Faculty Papers

We read with great interest and appreciation the careful consideration and analysis by Ambagtsheer et al. of the most critical ethical objections to Global Kidney Exchange (GKE). Ambagtsheer et al. conclude that implementation of GKE is a means to increase access to transplantation ethically and effectively.

Designing Peptides To Bind Kappa B Dna And Mimic Nf-Kappa B Protein Complexes, Nicholas A. Markowich

Honors College Theses

Transcription factors are important proteins that regulate gene expression and protein synthesis. Transcription factors can either boost the gene’s transcription rate by helping RNA polymerase activate transcription or restrict it by interfering with RNA polymerase, thereby repressing transcription. Nuclear factor-kappa-B (NF-κB) transcription factors are a family of proteins that control the synthesis of proteins involved in many cellular processes such as inflammatory and immune responses, cell growth, and apoptosis. However, the overexpression and activation of these transcription factors is linked to deadly conditions such as cancer and neurodegenerative diseases which currently have few safe cures. The goal of this research …

Non-Obstetrical Robotic-Assisted Laparoscopic Surgery In Pregnancy: A Systematic Literature Review., Courtney Capella, Joseph Godovchik, Thenappan Chandrasekar, Huda B. Al-Kouatly

Department of Urology Faculty Papers

Urologic and gynecologic surgeons are the top utilizers of robotic surgery; however, non-obstetrical robotic-assisted laparoscopic surgery (RALS) in pregnant patients is infrequent. A systematic literature review was performed to ascertain the frequency, indication and complications of RALS in pregnancy. Results showed thirty-eight pregnancies from eleven publications between 2008-2020. Five cases were for urologic indication and thirty-three for gynecologic indication. Minimal surgical alterations were required. Although no adverse maternal-fetal outcomes were reported, there are not enough cases published to determine safety. This review demonstrates the feasibility of RALS for the pregnant population in the hands of competent robotic surgeons.

Infant Massage And Bonding, Aly Blumenberg, Samantha Davis, Ali Graham, Rachel Medina, Emily Rayder

Master of Occupational Therapy Student Critically Appraised Topics

This project aims to appraise evidence of the effectiveness of infant massage for increasing social-emotional bonding. In our research, we focused on two studies considered Level I evidence and three studies considered Level II evidence. Study designs include quasi-experimental and randomized controlled trials. Strong evidence supports that infant massage increases social-emotional bonding and attachment. Based on the evidence, implementation varied from once per day for 10 minutes to 2-3 times per day for 15 minutes. It is recommended to use infant massage in an acute care setting and in the home to increase social-emotional bonding and attachment.

Pandemic 2020 In Myndsight, Shawn D. Denny

Reflections, Poetry, Photos, and other Writings

A poem, or rhapsodic reflection if you like, on the experience of being isolated due to the stay-at-home restrictions invoked by the pandemic. As my context is largely influenced by my involvement as a faculty and community member of Taylor University, the thoughts encapsulated also reflect that context.

2020-05-19 A Message From Chancellor Roth, Paul B. Roth

HSC Messages from the Chancellor

No abstract provided.

Efficacy Of Convalescent Plasma And Short Course Of Corticosteroids In Patients With Covid-19, Srikanth Ramachandruni, Po-Yang Tsou, D.C. Benetez, Gayathri Evani, Smitha Gudipati, Ramakrishna Chakilam, Polly Mock, Bharat Narasimhan, Dhanunjay Lakkireddy, Shekhar Raj

The University of Louisville Journal of Respiratory Infections

This study reported the efficacy of short-course corticosteroids and convalescent plasma (CP) transfusion in treating five patients with severe COVID-19 disease. Five adults (mean±standard deviation age: 70±9 years) with laboratory-confirmed COVID-19 and severe hypoxemia (PaO₂/FiO₂ [P/F]<100) requiring invasive mechanical ventilation received five days methylprednisolone (40 mg intravenously every 12 hours) and subsequent CP transfusion (250–400 ml). Compared with the baseline, P/F ratios increased by 46% and by 28% after short course corticosteroids and CP transfusion, respectively. Four patients survived. Short-course corticosteroids and CP transfusion may improve hypoxemia in patients with severe COVID-19 disease.