Medicine and Health Sciences Commons^™

2020-06-09_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

A Novel Chemically Differentiated Mouse Embryonic Stem Cell-Based Model To Study Liver Stages Of Plasmodium Berghei., Jaishree Tripathi, Charis-Patricia Segeritz, Gareth Griffiths, Wendy Bushell, Ludovic Vallier, William C Skarnes, Maria M Mota, Oliver Billker

Faculty Research 2020

Asymptomatic and obligatory liver stage (LS) infection of Plasmodium parasites presents an attractive target for antimalarial vaccine and drug development. Lack of robust cellular models to study LS infection has hindered the discovery and validation of host genes essential for intrahepatic parasite development. Here, we present a chemically differentiated mouse embryonic stem cell (ESC)-based LS model, which supports complete development of Plasmodium berghei exoerythrocytic forms (EEFs) and can be used to define new host-parasite interactions. Using our model, we established that host Pnpla2, coding for adipose triglyceride lipase, is dispensable for P. berghei EEF development. In addition, we also evaluated …

2020-06-09_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services

Michigan COVID-19 Long Term Care Data

The COVID Long Term Care Facilities page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173-526911--,00.html.

This report is created by the Michigan Department of Health & Human Services from data self-reported by long-term care facilities into EMResource. Data is updated on an ongoing basis.

The data below represents a cumulative total of COVID-19 resident cases reported by SNFs in Michigan since January 1, 2020. Facilities that did not report data are listed as “--.” Case numbers are provisional and may change as facilities correct or add data.
In addition, residents and family members should understand that the presence of …

2020-06-09_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) and rapid virus antigen detection point of care (POC) tests, look for current infection. Serology (antibody) tests are used to look for the possibility of previous infection.
Source: Michigan Disease Surveillance System (MDSS) and Vital Records

The website contained the tables …

Maternal Immune Activation Alters Fetal Brain Development And Enhances Proliferation Of Neural Precursor Cells In Rats, Kelly J. Baines, Dendra M. Hillier, Faraj L. Haddad, Nagalingam Rajakumar, Susanne Schmid, Stephen J. Renaud

Brain and Mind Institute Researchers' Publications

Maternal immune activation (MIA) caused by exposure to pathogens or inflammation during critical periods of neurodevelopment is a major risk factor for behavioral deficits and psychiatric illness in offspring. A spectrum of behavioral abnormalities can be recapitulated in rodents by inducing MIA using the viral mimetic, PolyI:C. Many studies have focused on long-term changes in brain structure and behavioral outcomes in offspring following maternal PolyI:C exposure, but acute changes in prenatal development are not well-characterized. Using RNA-Sequencing, we profiled acute transcriptomic changes in rat conceptuses (decidua along with nascent embryo and placenta) after maternal PolyI:C exposure during early gestation, which …

Association Between Changes In Subjective And Objective Measures Of Mobility In People With Lower Limb Amputations After Inpatient Rehabilitation, Gabrielle Cieslak, Humberto Omana, Edward Madou, Courtney Frengopoulos, Ricardo Viana, Michael W Payne, Susan W. Hunter

Physical Therapy Publications

Functional recovery for people with lower limb amputations is quantified using objective or subjective measures of performance. In this brief report, the prospective relationship between objective and subjective mobility after rehabilitation was evaluated in people with lower limb amputations. Adults undergoing inpatient prosthetic rehabilitation for a first unilateral transtibial or transfemoral level lower limb amputation were recruited. Assessment times: discharge and 4-mo follow-up. Gait velocity and the L Test under single- and dual-task conditions measured objective mobility. The Prosthetic Evaluation Questionnaire (section 4 and question 5b) measured subjective mobility. Paired t tests and Pearson correlation analysis evaluated change over time …

Discrimination Of Benign From Malignant Breast Lesions In Dense Breasts With Model-Based Analysis Of Regions-Of-Interest Using Directional Diffusion-Weighted Images., Alan I Penn, Milica Medved, Vandana Dialani, Etta D Pisano, Elodia B Cole, David Brousseau, Gregory S Karczmar, Guimin Gao, Barry D Reich, Hiroyuki Abe

Articles, Abstracts, and Reports

BACKGROUND: There is an increasing interest in non-contrast-enhanced magnetic resonance imaging (MRI) for detecting and evaluating breast lesions. We present a methodology utilizing lesion core and periphery region of interest (ROI) features derived from directional diffusion-weighted imaging (DWI) data to evaluate performance in discriminating benign from malignant lesions in dense breasts.

METHODS: We accrued 55 dense-breast cases with 69 lesions (31 benign; 38 cancer) at a single institution in a prospective study; cases with ROIs exceeding 7.50 cm

RESULTS: The region-growing algorithm for 3D lesion model generation improved inter-observer variability over hand drawn ROIs (DSC: 0.66 vs 0.56 (p < 0.001) with substantial agreement (DSC > 0.8) …

Applying Machine Learning To Neuroimaging Data To Identify Predictive Models Of Reading Disorder (Rd), Spencer Low

Honors Scholar Theses

Over the last 20 years, advances in computational neuroimaging and computational power have made it feasible to create predictive models (Woo et al. Nature Neuroscience 2017). Predictive modeling is an approach that uses pattern recognition techniques (machine learning) to develop models using brain data to predict clini­cal (or educational) outcomes, differential diagnosis and subtyping, and inform development of new treatments (Doyle et al Royal Society 2015, Haynes Neuron 2015, Orrù et al. NBR 2012; Woo et al. Nature Neuroscience 2017). In recent years, machine learning algorithms have been implemented to develop a model (pattern classifier) using neuroimaging data to predict …

2020-06-8/9 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Ingrid Hendrix, Lori D. Sloane, Mari Anixter, Anastasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Karen Armitage, Jenny Situ, Morgan Edwards-Fligner, Clinton Onyango, Perez Olewe, Cristian Bologa, Kristine Tollestrup, Douglas J. Perkins

HSC Covid 19 Briefings

Executive Summary:

NM Highlights: Governor’s interview. NM case count. Longer furlough for Santa Fe city employees. ABQ playgrounds reopening. Mask madness tournament. COVID-19 spending receipts. Zagster closes operations in ABQ. US Highlights: Shutdowns prevented deaths. Foster care delays. International Highlights: Scientist strike for anti-racism. New Zealand lifts lockdowns. Economics, Workforce, Supply Chain, PPE: WHO updates mask guidance. Software to manage PPE distribution. Centrifugation testing of masks. Sustain and preserve early career investigators. Epidemiology Highlights: WHO walks back statement on asymptomatic spread. Non-pharmaceutical interventions successful. Increased risk to intellectually and developmentally disabled. Epidemiologist risk tolerance surveyed. Healthcare Policy Recommendations: Public health …

Online Grocery Shopping By Nyc Public Housing Residents Using Supplemental Nutrition Assistance Program (Snap) Benefits: A Service Ecosystems Perspective, Nevin Cohen, Katherine Tomaino-Fraser, Chloe Arnow, Michelle Mulcahy, Christophe Hille

Publications and Research

This paper examines adoption of online grocery shopping, and potential cost and time savings compared to brick and mortar food retailers, by New York City public housing residents using Supplemental Nutrition Assistance Program (SNAP) benefits. A mixed methods action research project involving the co-creation of an online shopping club, the Farragut Food Club (FFC), recruited 300 members who registered to shop online using SNAP, and received waivers on delivery minimums and provided technical assistance and centralized food delivery. We conducted a survey (n = 206) and focus groups to understand shopping practices; FFC members collected receipts of groceries over two …

Translational Regulation Of Environmental Adaptation In Bacteria, Rodney Tollerson Ii, Michael Ibba

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Bacteria must rapidly respond to both intracellular and environmental changes to survive. One critical mechanism to rapidly detect and adapt to changes in environmental conditions is control of gene expression at the level of protein synthesis. At each of the three major steps of translation—initiation, elongation, and termination—cells use stimuli to tune translation rate and cellular protein concentrations. For example, changes in nutrient concentrations in the cell can lead to translational responses involving mechanisms such as dynamic folding of riboswitches during translation initiation or the synthesis of alarmones, which drastically alter cell physiology. Moreover, the cell can fine-tune the levels …

Motivators And Barriers Associated With Intent To Complete A Bsn For Hispanic Associate Degree Nurses, Marissa Jimenez

Nursing Theses and Dissertations

Hispanics who are registered nurses (RNs) are more likely to enter the nursing profession through an associate degree nursing program and are less likely than any other racial/ethnic groups to complete advanced degrees. The purpose of this study is to explain the relationship between motivators and barriers associated with the intent to complete a bachelor’s degree in nursing (BSN) for Hispanic associate degree nurses (ADNs). The research question for this study was, “how much variance in intent to complete a BSN do Hispanic associate degree nurses attribute to motivators and barriers to returning to school for RN to BSN?”

Ajzen’s …

This World Is Exhausting, Don’T Let It Exhaust You: Setting Emotional Boundaries To Prevent Fatigue, Mary Kate Schutt

Population Health Research Brief Series

How can you show compassion and empathy without draining your emotional energy? This issue brief provides tips on how to set personal boundaries to prevent emotional exhaustion.

Facing Real-World Challenges Of Immunogenicity In Pediatric Inflammatory Bowel Disease., Kyle Gress, Julie A. Bass, Ryan S Funk, Ryan Morrow, Rachel Hasenkamp, Valentina Shakhnovich

Manuscripts, Articles, Book Chapters and Other Papers

No abstract provided.

Bilingual And Bicultural Research Teams: Unpacking The Complexities., Maya I I. Ragavan, John Cowden

Manuscripts, Articles, Book Chapters and Other Papers

Researchers often describe use of "bilingual/bicultural" research teams, especially for research being conducted with marginalized communities. In this perspectives article, we argue that while increasing the diversity of research teams is imperative, using the term "bilingual/bicultural" without further explanation is problematic. We first review the nuances of the terms bilingual and bicultural individually. Next, we describe how the terms bilingual and bicultural cannot be conflated. Finally, we provide recommendations for researchers, journals, and funding agencies.

Pharmacy Students’ Perspectives On The Initial Implementation Of A Teaching Electronic Medical Record: Results From A Mixed-Methods Assessment, Olga O. Vlashyn, Omolola A. Adeoye-Olatunde, Kimberly S. Illingworth Plake, Jamie L. Woodyard, Zachary A. Weber, Alissa L. Russ-Jara

Department of Pharmacy Practice Faculty Publications

Background
Electronic medical records (EMRs) have been used for nearly three decades. Pharmacists use EMRs on a daily basis, but EMRs have only recently been incorporated into pharmacy education. Some pharmacy programs have implemented teaching electronic medical records (tEMRs), but best practices for incorporating tEMRs into pharmacy education remain unknown. The objectives of this study were to 1) assess pharmacy students’ views and experiences with a tEMR; and 2) identify current learning activities and future priorities for tEMR use in pharmacy education.

Methods
We used a mixed-methods approach, including three, two-hour student focus groups and a 42-item web-based survey to …

Contributions Of Gyra And Parc Mutations And Qnrs2 Acquisition To Ciprofloxacin Resistance In Aeromonas Veronii Hm21, Daniel J. Silverstein

Honors Scholar Theses

In recent years, ciprofloxacin resistant (CpR) Aeromonas veronii and A. hydrophila strains have been isolated from the wounds of patients receiving leech therapy. Genome comparisons of these CpR isolates revealed the presence of chromosomal mutations in gyrA and parC as well as the gain of qnrS2 on either a large, 34 kb, conjugatable, low-copy plasmid, pAv42, or on a small, 6.8 kb, high-copy plasmid, pAh1471. The minimum inhibitory concentration, MIC, for Cp of these clinical isolates ranged from 1 to ≥32 µg/mL and some harbored a qnrS2 containing plasmid. We wanted to assess the contributions of these factors in an …

Pneumonia-Induced Endothelial Amyloids Reduce Dendritic Spine Density In Brain Neurons, Allison M. Scott, Alexandrea C. Jager, Meredith Gwin, Sarah Voth, Ron Balczon, Troy Stevens, Mike T. Lin

University Faculty and Staff Publications

Pseudomonas aeruginosa pneumonia elicits endothelial cell release of cytotoxic amyloids that can be recovered from the bronchoalveolar lavage and cerebrospinal fluids of critically ill patients. Introduction of these cytotoxic amyloids into the lateral ventricle impairs learning and memory in mice. However, it is unclear whether the amyloids of lung origin (1) are neurotropic, and (2) cause structural remodeling of hippocampal dendrites. Thus, we used electrophysiological studies in brain slices and structural analysis of post-mortem tissues obtained from animals exposed to endothelium-derived amyloids to assess these issues. The amyloids were administered via three different routes, by intracerebroventricular, intratracheal, and intraperitoneal injections. …

Nurses And Needlesticks: Perceptions Of Stigma And Hiv Risk, Bethany Sharon Moore

USF Tampa Graduate Theses and Dissertations

Health-care providers (HCPs) are vulnerable to occupational health hazards, including dirty needle-stick injuries (DNSIs), which increase the risk for infection with HIV and other blood-borne pathogens. This study examines the perceptions of nurses and nurse practitioners who work in various health care settings regarding HIV-risk and DNSIs, in order to ascertain how these perceptions inform their decision-making regarding their health and nursing practice. I utilize a phenomenological approach to analyze the lived reality and embodiment of the DNSI experience by HCPs. The study explores the personal and institutional level factors that may influence the timely reporting and treatment of DNSIs, …

Idiopathic Pulmonary Hemosiderosis - A Rare Cause Of Chronic Anemia, Ayesha Butt, Rashida Ahmed, Muhammad Dawood Amir Sheikh, Omar Khan, Nousheen Iqbal, Arshalooz Rahman, Javaid Khan

Medical College Documents

Idiopathic pulmonary hemosiderosis (IPH) is a rare disease marked by alveolar bleeding and accumulation of hemosiderin in the lungs. Here we present three cases of IPH. The first case is of a 26-year-old male with anemia, hemoptysis and dyspnea. Bronchoscopy confirmed diffuse alveolar hemorrhage (DAH). A diagnosis of IPH was made after ruling out other causes of DAH and observing good response to steroids. The patient's condition improved with prednisolone and azathioprine. The second case is of 26-year-old female with severe anemia. Imaging suggested IPH and lung biopsy confirmed it. She died shortly afterwards. The third case is of a …

Implications Of New Understandings Of Gliomas In Children And Adults With Nf1: Report Of A Consensus Conference, Roger J Packer, David H Gutmann, Et Al.

2020-Current year OA Pubs

Gliomas are the most common primary central nervous system tumors occurring in children and adults with neurofibromatosis type 1 (NF1). Over the past decade, discoveries of the molecular basis of low-grade gliomas (LGGs) have led to new approaches for diagnosis and treatments. However, these new understandings have not been fully applied to the management of NF1-associated gliomas. A consensus panel consisting of experts in NF1 and gliomas was convened to review the current molecular knowledge of NF1-associated low-grade "transformed" and high-grade gliomas; insights gained from mouse models of NF1-LGGs; challenges in diagnosing and treating older patients with NF1-associated gliomas; and …

Evaluation Of An Innovative Transitional Care Clinic In An Interprofessional Teaching Practice, Mckenzie Calhoun Highsmith, Jesse Gilreath, Peter Bockhorst, Kathleen White, Beth Bailey

International Journal of Health Sciences Education

During transitions of care, great opportunity exists for miscommunication, poor care coordination, adverse events, medication errors and unnecessary healthcare utilization costing billions of dollars annually. An Interprofessional Transitions of Care (IPTC) clinic was developed utilizing a Family Medicine team that included physicians, nurses, a clinical social worker, and a clinical pharmacist. The purpose of this study was to determine if utilization of an IPTC clinic prevented hospital readmission, and to identify factors that predict most benefit from an interprofessional approach to transitions of care. A retrospective chart review of 1,001 patients was completed. A treatment group (TG) of 501 patients …

The Impact Of An International Interprofessional Experience On Perceptions Of Pharmacist-Physician Relationships, Miranda R. Andrus, Emily A. Powell, Katherine Moody, Taylor D. Steuber

International Journal of Health Sciences Education

Objective. To assess the impact of this international interprofessional learning experience on perceptions of pharmacist-physician relationships and interprofessional teams.

Methods. Medical and pharmacy students completed a one-week interprofessional medical mission experience in the Dominican Republic. Anonymous surveys were administered to 17 students before and after completion to measure perceptions of pharmacist-physician relationships and interprofessional teams. Responses were matched and changes in perceptions were analyzed using the Wilcoxon Signed Rank test. The SPICE-R2 instrument was administered after the experience to measure attitudes toward interprofessional teams.

Results. Of the 17 participants, 100% responded to all surveys. Significant improvements were seen in the …

Fit For Population Health Service: Assessing The Change In Public Health Competencies Of Interprofessional Undergraduate Health Sciences Students, Cassity Gutierrez, Sara Johnston

International Journal of Health Sciences Education

Background. A 2012 IOM report is just one of an increasing number of recommendations to incorporate a population health approach into training of all health professionals. In light of the emphasis on and necessity for all future health professionals to possess core public health competences, a medium sized public University incorporated Introduction to Public Health as a required course in their undergraduate, interprofessional Health Sciences curriculum.

Purpose. The purpose of this study was to assess the change in core public health competencies of undergraduate Health Sciences students who completed an Introduction to Public Health course.

Methods. The Tier 1 …

Approachability Of The Nursing Clinical Instructor: Psychometric Assessment Of A Scale Development, Angela Collier

International Journal of Health Sciences Education

Approachability of nursing clinical instructors is largely unknown and misunderstood, yet critical for millennial students which currently comprise 82% of nursing students (National League for Nursing, 2014). Nursing education consists of both a didactic and a clinical component. Clinical education is dynamic and allows the student an experiential learning opportunity. Therefore, clinical nursing educators are vitally important. Approachability has been identified in many studies as a leading characteristic of an effective instructor. Although the importance of approachability of the instructor is established, currently no scale exists to measure this concept. The purpose of this study was to examine the validity …

Approachability Of The Instructor Within The Context Of Nursing Clinical Education: A Concept Analysis Using Rodger's Evolutionary Method, Angela Collier

International Journal of Health Sciences Education

Aim: The aim of the study is to report an analysis of the concept of approachability of the instructor within the context of nursing clinical education.

Background: Approachability of the instructor within the context of a nursing clinical education is a concept that is obscure and immature.

Design: Concept Analysis

Data Sources: A literature search between the years 1985 to present yielded 18 articles that were analyzed.

Method: Rodger’s Evolutionary Method was used for the concept analysis.

Results: The concept analysis identified the antecedents, attributes and consequences of approachability of the clinical nursing instructor. The antecedent was a …

"Thinking Across Borders." 13th Annual Research Week: Event Proceedings, Office Of Research And Sponsored Projects Operations

Excellence Summit (Research Week) Archived Proceedings

Poster and podium presentations of research by students and faculty of University of the Incarnate Word.

Characterizing Middle School Students’ Physical Literacy: A Sequential Mixed Methods Study, Yang Liu

LSU Doctoral Dissertations

The purpose of this dissertation study was (a) to characterize middle school students’ levels of physical literacy (PL) and PL domains by gender, grade, socioeconomic status (SES), weight status, race, and ethnicity; and (b) to capture PL trajectory change as a result of receiving a theory-informed pedagogical workshop. Participants (N = 350) in sixth and seventh grades were recruited from a public middle school located in a southeastern U.S. state. These students completed the second version of the Canadian Assessment of Physical Literacy (CAPL-2). A subsample (n = 49) received a pedagogical workshop (four sessions over eight weeks), …

Validity Of The Stent Thrombosis Risk Score In Predicting Early Stent Thrombosis After Primary Percutaneous Coronary Intervention, Rajesh Kumar, Sahar Tariq, Madiha Fatima, Tahir Saghir, Mahesh Kumar Batra, Musa Karim, Jawaid Akbar Sial, Naveedullah Khan, Syed Nadeem Hasan Rizvi

Journal of the Saudi Heart Association

Background: The thrombosis of the stent is one of the most important complications of percutaneous interventions, resulting in complete occlusion of the stented vessel. Aim of this study was to determine the validity of Stent Thrombosis Risk Score (STRS) in predicting early stent thrombosis (ST) after primary Percutaneous Coronary Intervention (PCI)

Methods: For this study, 569 consecutive patients undergone primary PCI from July 2018 to December 2018 were recruited. Early ST was defined as ST occurred during or within 30 days after the procedure. The STRS was calculated as proposed, developed, and validated in a past study. The …

2020-06-08_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

The webpage was obtained from Michigan's Coronavirus Cumulative Data page, under the link Data About Places. Data is self-reported by hospitals daily to the EM Resource System per MDHHS Director Robert Gordon's Emergency Order.

Contains the tables Statewide Available Bed Tracking for COVID-19, COVID-19 Metrics, Statewide Available PPE Tracking for COVID-19 (Statewide Available PPE and Bed Tracking), as well as the tables PPE Days On Hand and Patient Census.