Medicine and Health Sciences Commons^™

The History Of Early Modern Medicine In New Spain, El Primero Sueño, And Poet Sor Juana Inés De La Cruz, Daniel Hughes

Grand Valley Journal of History

This essay analyzes poetry and other writing by Sor Juana Inés de la Cruz in the context of themes from Greco-Roman antiquity and the historical development of medicine in seventeenth century New Spain, now Mexico. Sor Juana’s El Primero Sueño, a Spanish language poetic silva, exhibits copious references to writers from classical antiquity, including Aristotle and Ovid. Establishing a context steeped in ideas from Greco-Roman antiquity, Sor Juana invokes the medical and philosophical legacy of foundational physician Galen of Pergamon. She also expands upon his ideas into the human anatomical realm, reflecting the increased early modern prominence of …

Ontologies, Knowledge Representation, And Machine Learning For Translational Research: Recent Contributions, Peter N Robinson, Melissa A. Haendel

Faculty Research 2020

No abstract provided.

Genetic Variants And Functional Pathways Associated With Resilience To Alzheimer's Disease., Logan Dumitrescu, Emily R Mahoney, Shubhabrata Mukherjee, Michael L Lee, William S Bush, Corinne D Engelman, Qiongshi Lu, David W Fardo, Emily H Trittschuh, Jesse Mez, Catherine Kaczorowski, Hector Hernandez Saucedo, Keith F Widaman, Rachel Buckley, Michael Properzi, Elizabeth Mormino, Hyun-Sik Yang, Tessa Harrison, Trey Hedden, Kwangsik Nho, Shea J Andrews, Doug Tommet, Niran Hadad, R Elizabeth Sanders, Douglas M Ruderfer, Katherine A Gifford, Annah M Moore, Francis Cambronero, Xiaoyuan Zhong, Neha S Raghavan, Badri Vardarajan, Margaret A Pericak-Vance, Lindsay A Farrer, Li-San Wang, Carlos Cruchaga, Gerard Schellenberg, Nancy J Cox, Jonathan L Haines, C Dirk Keene, Andrew J Saykin, Eric B Larson, Reisa A Sperling, Richard Mayeux, David A Bennett, Julie A Schneider, Paul K Crane, Angela L Jefferson, Timothy J Hohman

Faculty Research 2020

Approximately 30% of older adults exhibit the neuropathological features of Alzheimer's disease without signs of cognitive impairment. Yet, little is known about the genetic factors that allow these potentially resilient individuals to remain cognitively unimpaired in the face of substantial neuropathology. We performed a large, genome-wide association study (GWAS) of two previously validated metrics of cognitive resilience quantified using a latent variable modelling approach and representing better-than-predicted cognitive performance for a given level of neuropathology. Data were harmonized across 5108 participants from a clinical trial of Alzheimer's disease and three longitudinal cohort studies of cognitive ageing. All analyses were run …

Glut1 Deficiency: Retinal Detrimental Effects Of Gliovascular Modulation, Matt Henry, John Kitchens, Juan M. Pascual, Ramiro S. Maldonado

Ophthalmology and Visual Science Faculty Publications

No abstract provided.

Policy, Systems, And Environmental Change: A Planning Tool For Community Health Implementation, Lauren E. Kennedy, Christopher T. Sneed, Karen L. Franck, Heather Norman, Lisa Washburn, Soghra Jarvandi, Janet Mullins

Dietetics and Human Nutrition Faculty Publications

Extension educators across the United States are being asked to expand their direct education efforts to include policy, systems, and environmental (PSE) changes. However, professional development opportunities and tools are needed to familiarize Extension professionals with PSE change approaches, build their capacity to implement PSE change, and make the process relevant to their work. We describe a planning tool developed for a unique multistate PSE change intervention training and designed to facilitate the process of PSE change implementation at the local level. An example of the tool and recommendations for others wishing to use it are included.

Two States, One Mission: Building Policy, Systems, And Environmental Change Capacity Of County Extension Educators, Christopher T. Sneed, Karen L. Franck, Heather Norman, Lisa Washburn, Lauren E. Kennedy, Soghra Jarvandi, Janet Mullins

Dietetics and Human Nutrition Faculty Publications

Policy, systems, and environmental (PSE) change interventions are a key part of comprehensive nutrition and health education. Although Extension educators find value in PSE approaches and report being involved in PSE work, many still indicate a lack of understanding regarding PSE approaches. We describe a unique multistate training designed to increase Extension educators' understanding, skills, and capacity related to implementing PSE change interventions. Data demonstrating success of the training are presented. Additionally, best practices for others wishing to create similar multistate programs conclude the article.

Heartland Virus In Lone Star Ticks, Alabama, Usa, Brent C. Newman, William B. Sutton, Abelardo C. Moncayo, Holly R. Hughes, Ali Taheri, Thomas C. Moore, Callie J. Schweitzer, Yong Wang

Agricultural and Environmental Sciences Faculty Research

We detected Heartland virus (HRTV) in lone star nymphs collected in 2018 in northern Alabama, USA. Real-time reverse transcription PCR selective for the small segment of the HRTV genome and confirmatory sequencing of positive samples showed high identity with HRTV strains sequenced from Tennessee and Missouri.

The Apoptotic Effect Of Gsk-3 Inhibitors: Bio And Chir 98014 On H1975 Lung Cancer Cells Through Ros Generation And Mitochondrial Dysfunction., Theodore Lemuel Mathuram, Thiagarajan Venkatesan, Jayanta Das, Umamaheswari Natarajan, Appu Rathinavelu

HPD Articles

OBJECTIVE: GSK-3 has been reported to be upregulated in malignant diseases, including lung cancers, thus suggesting it to be a valid target for cancer treatment. The study elucidates the possible mechanism involved in the ability of GSK-3 inhibitors: BIO and CHIR 98014 to regulate proteins involved in cell death of H1975 lung cancer cells.

RESULTS: BIO and CHIR 98014 successfully induced apoptosis at lower concentrations in H1975 cells but not in H460 lung cancer cells. Moreover, increased ROS generation and depolarization of mitochondrial membrane potential were observed in both treatments. Cleavage of caspase-3 was observed in both BIO and CHIR …

Michigan Food Insecurity, Food Access, And Food Worries During The Covid-19 Pandemic, Alyssa W. Beavers, Michelle M. Litton

Nutrition and Food Science Faculty Research Publications

No abstract provided.

Treatment With Hydroxychloroquine, Azithromycin, And Combination In Patients Hospitalized With Covid-19, Samia Arshad, Paul Kilgore, Zohra S. Chaudhry, Gordon Jacobsen, Dee Dee Wang, Kylie Huitsing, Indira Brar, George J. Alangaden, Mayur S. Ramesh, John E. Mckinnon, William O'Neill, Marcus Zervos, Henry Ford Covid-19 Task Force

Department of Pharmacy Practice

Significance: The United States is in an acceleration phase of the COVID-19 pandemic. Currently there is no known effective therapy or vaccine for treatment of SARS-CoV-2, highlighting urgency around identifying effective therapies.

Objective: The purpose of this study was to evaluate the role of hydroxychloroquine therapy alone and in combination with azithromycin in hospitalized patients positive for COVID-19.

Design: Multi-center retrospective observational study.

Setting: The Henry Ford Health System (HFHS) in Southeast Michigan: large six hospital integrated health system; the largest of hospitals is an 802-bed quaternary academic teaching hospital in urban Detroit, Michigan.

Participants: Consecutive patients hospitalized with a …

Lung Cancer And Kidney Injury: An Updated Review, Bhargav Patel, Mohammad Ebrahimi Kalan, Maryam Khosravian, Audrey C. Tolouian, Ramin Tolouian, Mahnaz Aboufazeli, Masoumeh Asgharpour, Amirhesam Alirezaei

Nursing Faculty Publications

Lung cancer is the leading cause of cancer deaths worldwide, accounting for an estimated 1.8 million deaths. Lung cancer is also the most common primary cancer leading to soft tissue (ST) metastasis. Renal disease may occur as a direct or indirect consequence of the cancer itself (e.g., postrenal obstruction, compression, or infiltration), its treatment (e.g., radiotherapy or chemotherapy), or its related complications (e.g., opportunistic infection). Existing evidence shows that the most frequent primary solid tumor responsible for renal metastasis is pulmonary carcinoma, followed by gastric, breast, soft tissue, and thyroid carcinomas. Chronic kidney disease is a potential risk factor in …

Pediatric Blunt Cerebrovascular Injury: Identifying Common Symptomatologies To Improve Screening Guidelines A Literature Review And Case Study, Natasha Kuklis, Dima Khalil, Sarah A. Jones Sapienza Md

Research Scholars Poster Presentation

No abstract provided.

Great Catches For Patient Safety, Lehigh Valley Health Network

Awards

No abstract provided.

Screening For More Than 1,000 Pesticides And Environmental Contaminants In Cannabis By Gc/Q-Tof, Philip L. Wylie, Jessica Westland, Mei Wang, Mohamed M. Radwan

Faculty and Student Publications

A method has been developed to screen cannabis extracts for more than 1,000 pesticides and environmental pollutants using a gas chromatograph coupled to a high-resolution accurate mass quadrupole time-of-flight mass spectrometer (GC/Q-TOF). An extraction procedure was developed using acetonitrile with solid phase extraction cleanup. Before analysis, extracts were diluted 125:1 with solvent. Two data mining approaches were used together with a retention-time-locked Personal Compound Database and Library (PCDL) containing high-resolution accurate mass spectra for pesticides and other environmental pollutants. (1) A Find-by-Fragments (FbF) software tool extracts several characteristic exact mass ions within a small retention time window where the compound …

Physical Activity, Sedentary Behavior, And Sleep Quality In Adults With Primary Hypertension And Obesity Before And After An Aerobic Exercise Program: Exerdiet-Hta Study, Aitor Martinez Aguirre-Betolaza, Iñigo Mujika, Paul Loprinzi, Pablo Corres, Ilargi Gorostegi-Anduaga, Sara Maldonado-Martín

Faculty and Student Publications

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Background: The purposes of the study were to: analyze, by objective (accelerometry) and subjective (International Physical Activity Questionnaire, IPAQ) methodologies, the physical activity (PA) and sedentary behavior (SB) in healthy adults (HEALTHY, n = 30) and individuals with primary hypertension (HTN) and overweight/obesity (n = 218); assess the effects of an aerobic exercise intervention on physical activity (PA), sedentary behavior (SB), and sleep quality in the HTN group; and evaluate the relationship between objectively measured and subjectively reported PA and SB. Methods: The measurements were performed before a 16-week exercise intervention …

Prion Protein Lowering Is A Disease-Modifying Therapy Across Prion Disease Stages, Strains And Endpoints, Eric Vallabh Minikel, Hien T. Zhao, Jason Le, Jill O'Moore, Rose Pitstick, Samantha Graffam, George A. Carlson, Michael P. Kavanaugh

Biomedical and Pharmaceutical Sciences Faculty Publications

Lowering of prion protein (PrP) expression in the brain is a genetically validated therapeutic hypothesis in prion disease. We recently showed that antisense oligonucleotide (ASO)-mediated PrP suppression extends survival and delays disease onset in intracerebrally prion-infected mice in both prophylactic and delayed dosing paradigms. Here, we examine the efficacy of this therapeutic approach across diverse paradigms, varying the dose and dosing regimen, prion strain, treatment timepoint, and examining symptomatic, survival, and biomarker readouts. We recapitulate our previous findings with additional PrP-targeting ASOs, and demonstrate therapeutic benefit against four additional prion strains. We demonstrate that

America At A Glance: Social Isolation And Loneliness During The First Wave Of Covid-19, University Of Montana Rural Institute

Health and Wellness

Social isolation and loneliness are a public health concern because they are associated with poor mental and physical health outcomes and mortality. To learn more about how COVID-19 and related responses (i.e. stay-at-home orders) may contribute to feelings of social isolation and loneliness among people with disabilities, we compared data from two cross-sectional samples collected before and after the first wave of “stay-at-home” orders. Post-COVID rural and urban samples reported significantly more interactions with family and close friends. Post-COVID urban respondents reported significantly lower rates of feeling left out, while the post-COVID rural respondents reported similar rates.

Nursing And Caregiver Satisfaction And The Implementation Of A Discharge Education Roadmap For Newly Diagnosed Pediatric Oncology Patients., Sable Iglesias

Doctor of Nursing Practice Papers

The initial diagnosis of a pediatric cancer is a stressful and overwhelming experience. During this time, distressed caregivers are expected to learn about the diagnosis, treatment plan, and how to care for their child at home. Simultaneously, parental reactions to a new cancer diagnosis often make learning a difficult process. The discharge education process is often a responsibility of the nursing staff. However, there are currently no evidence-based, systematic guidelines to direct the discharge education process of newly diagnosed pediatric oncology patients. Consequently, there is a lack of standardization across institutions, resulting in considerable variability in content provided in teaching …

Heart Failure With Reduced Ejection Fraction, Shawn Barkalow

Nursing Student Class Projects (Formerly MSN)

Heart failure (HF) is a complex disease the requires a high-level understanding of pathophysiology and physics. Heart failure is an umbrella term with multiple subsets beneath it. Heart failure with reduced ejection fraction relates to a failing left ventricle with an ejection fraction (EF) of less than 40%. Inability to push fluid forward causes the heart rate to increase, neurohormonal changes and creates a backup of flow into the lungs creating dyspnea. Applied physics plays a large role in understand heart failure. Frank-starling’s curve, Ohm’s, Poiseulle’s and Laplace’s laws all apply to the physiological principles behind preload, afterload, and contractility. …

Sepsis Pathophysiology, Samantha Kingsley

Nursing Student Class Projects (Formerly MSN)

Sepsis is one of the most common diagnoses in medical intensive care units (MICUs) worldwide. Sepsis is a medical emergency where prompt intervention is vital to promoting positive patient outcomes. Septic shock develops when sepsis has progressed to the point of persistent hypotension despite appropriate fluid resuscitation. It is important to recognize the early signs of sepsis and intervene to prevent further progression. As the understanding of the pathophysiology has developed further over the years, the treatments and outcomes associated with sepsis have also improved. However, prompt recognition and intervention have always been at the forefront of management and should …

Covid-19 Video Visits Reduces Racial Barriers To Care: Sociodemographic Factors That Influence Access To Virtual Care, Naomi Ganpo-Nkwenkwa, Kyle Shaak Bs, Beth Careyva M.D., Grant M. Greenberg M.D., M.H.S.A., M.A.

Research Scholars Poster Presentation

No abstract provided.

Assessment Of The Sexually Transmitted Infection Testing At Lvhn In Symptomatic Patients Who Present To The Emergency Department Or Ambulatory Setting, Sarah Vetesi, Marcelo Gareca Md, Amy Slenker Md

Research Scholars Poster Presentation

No abstract provided.

Improving Primary Care Pre-Visit Planning, Brandy Moser, Johnny Stoeckle Md, Kyle Shaak Mph

Research Scholars Poster Presentation

No abstract provided.

The Need For Neurosurgical Intervention In Trauma Patients With A Positive Ct Scan And Glasgow Coma Scale Of 13-15, Justin Pasquale, James Cipolla, Mark Cipolle Md, Puja Patel Md, Jennifer Macfarlan

Research Scholars Poster Presentation

No abstract provided.

Building A Book Of Benefits: Producing A Community Resource Guide To Support Persons Experiencing Homelessness, Morgan Storino, Hoonani M. Cuadrado, Bennie Eliason Chw

Research Scholars Poster Presentation

No abstract provided.

Identifying Pcp Follow-Up And Readmission Rates Of Internal Medicine-Muhlenberg Patients, Madison Smith, Victoria Chestnut Dnp, Mba, Rn, Ccctm

Research Scholars Poster Presentation

No abstract provided.

Characterization Of Microbiology And Associated Antibiotic Usage In The Neonatal Intensive Care Unit, Bridget Lunney, Tibisay Villalobos Md, Faap, Kristin M. Held-Wheatley Pharmd, Bcop

Research Scholars Poster Presentation

No abstract provided.

Implementing A Student Information System And Creating A Data Collection System In A School Of Nursing, Hunter Krauss, Michele Siminitus Ms, Lynne Hausman Msn, Rn, Cne

Research Scholars Poster Presentation

No abstract provided.

Coordinating And Improving The Quality Of Care In Patients With Gastro Esophageal Reflux Disease (Gerd), Daniel Elmi, Scott Beman Md, Jennifer Macfarlan Mph

Research Scholars Poster Presentation

No abstract provided.

The Impact Of Multiplex Respiratory Pathogen Pcr Testing At A Large Academic Institution, Hailey Reiss, Jarrod W. Kile Rphd, Bcps, Eric Young Md

Research Scholars Poster Presentation

No abstract provided.