Medicine and Health Sciences Commons^™

Harnessing Real-World Data To Inform Decision-Making: Multiple Sclerosis Partners Advancing Technology And Health Solutions (Ms Paths)., Ellen M Mowry, Robert A Bermel, James R Williams, Tammie L S Benzinger, Carl De Moor, Elizabeth Fisher, Carrie M Hersh, Megan H Hyland, Izlem Izbudak, Stephen E Jones, Bernd C Kieseier, Hagen H Kitzler, Lauren Krupp, Yvonne W Lui, Xavier Montalban, Robert T Naismith, Jacqueline A Nicholas, Fabio Pellegrini, Alex Rovira, Maximilian Schulze, Björn Tackenberg, Mar Tintore, Madalina E Tivarus, Tjalf Ziemssen, Richard A Rudick

Neuroscience Articles

Background: Multiple Sclerosis Partners Advancing Technology and Health Solutions (MS PATHS) is the first example of a learning health system in multiple sclerosis (MS). This paper describes the initial implementation of MS PATHS and initial patient characteristics. Methods: MS PATHS is an ongoing initiative conducted in 10 healthcare institutions in three countries, each contributing standardized information acquired during routine care. Institutional participation required the following: active MS patient census of ≥500, at least one Siemens 3T magnetic resonance imaging scanner, and willingness to standardize patient assessments, share standardized data for research, and offer universal enrolment to capture a representative sample. …

Without Words: Relational Neuropsychology And Creative Arts Therapies With People Managing Aphasia, Autumn Marie Chilcote

Electronic Theses and Dissertations

Aphasia describes the broad experience of disrupted language production or comprehension acquired after structural changes in the brain. These changes, usually associated with stroke, tumor, or cortical degeneration, are often co-occurring with other symptoms, such as emotional dysregulation, partial paralysis, and difficult social, occupational, and community relationships. Common approaches to research and rehabilitation with persons managing aphasia highlight conversation and semantic retrieval, with a lack in literature considering the diversity of symptoms and responses. Questions arise as to the ways that psychotherapies, typically language- centered, can be adapted to collaborative, low-verbal approaches that attend to the range of individual symptoms …

Harm Reduction In Prison Settings: A Relevant Approach To Reduce Hiv Transmission?, Amine Ghrabi

International Programs

Harm reduction defines a set of policies and interventions aiming to address the adverse health consequences associated with drug use. Compared to the general population, prisoners are disproportionally affected by HIV. Thanks to its strong emphasis on public health and human rights principles, harm reduction can effectively reduce transmission of HIV inside prison settings.

Particulate Matter Pollution And Its Effect On Covid-19, Aída Fica Conejeros

International Programs

Growing research supports the significant effects of particulate matter on COVID-19. This air pollutant has been identified before as responsible for serious respiratory diseases. Studies on the differences in high and low polluted cities confirmed that COVID-19 not only correlates to the number of infections but also, increases of 1 ��g/m3 can cause a mortality rate to rise by 8% and the hospital admissions by 4.4%. However, laboratory studies are still needed to support these findings.

Access To Treatment For People With Hiv: Do Latin American Governments Cover Medical Treatment For People With Hiv-Aids Who Cannot Afford It?, Veronica M. Belmonte

International Programs

I will analyze different Latin American Supreme Court rulings in order to demonstrate that governments are obliged to cover universal medical treatments for people with HIV. This is a worldwide issue and UNAIDS is constantly working to protect this vulnerable group of people. We can see this progress in the following statistics.

Surgical Techniques Of Gummy Smile Correction, Jamila Belaid

International Programs

No abstract provided.

Why Some People Consume Counterfeit Drugs In Benin, Maxime A. Ahouansou

International Programs

Despite the threat counterfeit drugs represent to health and the government’s endeavor to discourage their consumption, some people in Benin still prefer buying medicine in the underground economy. This research purported to understand the causes of the phenomenon. The research method used a survey of a sample of sixty-eight people randomly selected at Cotonou, a city with a population representative of Benin general population status regarding socio-economic conditions. The data about people's habits regarding drug consumption, monthly income, insurance coverage, and reasons why people chose to buy counterfeit medicines were collected and analyzed using Excel Spreadsheet. The analysis of those …

Therapeutic Hypothermia, False Hope In Cooling, Katherine Zuniga

MSN Capstone Projects

According to the American Heart Association (2018), every year 356,000 people suffer from cardiac arrest. In the vast majority of these cases, the patient is unable to be resuscitated. However, for the individuals for whom Return of Spontaneous Circulation (ROSC) is achieved, the AHA recommends targeted temperature management or therapeutic hypothermia. TH is the process of cooling a comatose person in hopes of preserving neurological function. However, despite this intervention, many still perish or do not retain their prior level of function. In post cardiac arrest patients, what is the effect of therapeutic hypothermia compared to maintaining normothermia on patient …

Investigating The Psychometric Properties Of The Carers’ Fall Concern Instrument To Measure Carers’ Concern For Older People At Risk Of Falling At Home: A Cross-Sectional Study, Seng Giap Marcus Ang, Anthony Paul O’Brien, Amanda Wilson

Research outputs 2014 to 2021

Aims: This study aimed to investigate the psychometric properties of the Carers’ Fall Concern Instrument (CFC-I) for measuring carers’ concern for older people (care recipients) at risk of falling.

Background: Family carers are crucial in preventing older people from falling at home. Their concerns for older people at risk of falling have severe implications on carers’ psychological well-being and ability to prevent falls. However, there is no validated instrument measuring this concern.

Methods: A cross-sectional study was used to examine the validity and reliability of the CFC-I. Carers looking after older people living at home completed the 17-item CFC-I and …

Tonic Tcr Signaling Inversely Regulates The Basal Metabolism Of Cd4+ T Cells, Ashley A Viehmann Milam, Juliet M Bartleson, Michael D Buck, Chih-Hao Chang, Alexey Sergushichev, David L Donermeyer, Wing Y Lam, Erika L Pearce, Maxim N Artyomov, Paul M Allen

2020-Current year OA Pubs

The contribution of self-peptide-MHC signaling in CD4

Effects Of Food Gums And Pre-Drying On Fat Content Of Fabricated Fried Chips, Jane C. Lumanlan, Warnakulasuriya M.A.D.B. Fernando, Weeraya Karnpanit, Vijay Jayasena

Research outputs 2014 to 2021

Deep-frying contributes to the unique taste and texture of fried products. However, they are low in nutritional value. Food industries actively trying to find ways to reduce the fat content while maintaining organoleptic properties of fried foods. In this work, effects of pre-drying and adding food gums on the moisture and fat contents of chips were evaluated. The chips were pre-dried for 60 and 90 min, and gellan gum, guar gum, methylcellulose and xanthan gum were added at the concentration of 0.25, 0.75, 1 and 2 % w/w. The xanthan gum was the most effective gum for fat reduction. The …

Contemporary Interventional Radiology Employment: Analysis Of The American College Of Radiology And The Society Of Interventional Radiology Occupational Portals, Anthony N Hage, Vibhor Wadhwa, Eric J Monroe, David S Shin, Jeffrey Forris Beecham Chick

Department of Radiology Faculty Papers

No abstract provided.

Measuring Listening Effort Using Physiological, Behavioral And Subjective Methods In Normal Hearing Subjects: Effect Of Signal To Noise Ratio And Presentation Level, Lakshmi Magudilu Srishyla Kumar

Dissertations, 2020-current

The main objective of the study is to compare the effectiveness of pupillometry, working memory and subjective rating scale —the physiological, behavioral, and subjective measures of listening effort— at different signal to noise ratios (SNR) and presentation levels: when administered together. Eleven young normal hearing individuals with mean age of 21.7 years (SD=1.9 years) participated in the study. The HINT sentences were used for speech perception in noise task. The listening effort was quantified using peak pupil dilation, working memory, working memory difference, subjective rating of listening and recall effort. The rating of perceived performance, frustration level and …

Dendritic Cell Derived Exosomes Loaded With Immunoregulatory Cargo Reprogram Local Immune Responses And Inhibit Degenerative Bone Disease In Vivo, Mahmoud Elashiry, Mohamed M Elashiry, Ranya Elsayed, Mythily Rajendran, Carol Auersvald, Rana Zeitoun, Mohammad H Rashid, Roxan Ara, Mohamed M Meghil, Yutao Liu, Ali S Arbab, Roger M Arce, Mark Hamrick, Mohammed Elsalanty, Marshall Brendan, Rafal Pacholczyk, Christopher W Cutler

Faculty, Staff and Student Publications

Chronic bone degenerative diseases represent a major threat to the health and well-being of the population, particularly those with advanced age. This study isolated exosomes (EXO), natural nano-particles, from dendritic cells, the "directors" of the immune response, to examine the immunobiology of DC EXO in mice, and their ability to reprogram immune cells responsible for experimental alveolar bone loss

Promoting Community Engagement Through Basic User Tutorial Of Epa Geospatial Screening Tools, Jonas Nguyen

Master's Projects and Capstones

Social inequalities are riddled with health disparities and outcomes leading toward lower life expectancy. Communities of color, low income, and rural neighborhoods lack the voice and resources to effectively oppose industrial settlement which would likely lead to the release of toxic wastes into the water, air and ground ultimately affecting residential health. Empowering members through community engagement is a relatively new strategic process where researchers are finding mutual benefits in design, implementation, and results. This study aims to identify and promote tools for community engagement within the scope of environmental justice by working with EPA geospatial screening tools and designing …

Mg2+-Dependent Methyl Transfer By A Knotted Protein: A Molecular Dynamics Simulation And Quantum Mechanics Study, Agata P Perlinska, Marcin Kalek, Thomas Christian, Ya-Ming Hou, Joanna I Sulkowska

Department of Biochemistry and Molecular Biology Faculty Papers

Mg2+ is required for the catalytic activity of TrmD, a bacteria-specific methyltransferase that is made up of a protein topological knot-fold, to synthesize methylated m1G37-tRNA to support life. However, neither the location of Mg2+ in the structure of TrmD nor its role in the catalytic mechanism is known. Using molecular dynamics (MD) simulations, we identify a plausible Mg2+ binding pocket within the active site of the enzyme, wherein the ion is coordinated by two aspartates and a glutamate. In this position, Mg2+ additionally interacts with the carboxylate of a methyl donor cofactor S-adenosylmethionine (SAM). The computational results are validated by …

Alport Syndrome Classification And Management., Bradley A. Warady, Rajiv Agarwal, Sripal Bangalore, Arlene Chapman, Adeera Levin, Peter Stenvinkel, Robert D. Toto, Glenn M. Chertow

Manuscripts, Articles, Book Chapters and Other Papers

Alport syndrome affects up to 60,000 people in the United States. The proposed reclassification of thin basement membrane nephropathy and some cases of focal segmental glomerulosclerosis as Alport syndrome could substantially increase the affected population. The reclassification scheme categorizes Alport syndrome as 3 distinct diseases of type IV collagen α3/4/5 based on a genetic evaluation: X-linked, autosomal, and digenic. This approach has the advantage of identifying patients at risk for progressive loss of kidney function. Furthermore, the shared molecular cause of Alport syndrome and thin basement membrane nephropathy arises from mutations in the COL4A3, COL4A4, and COL4A5 genes, …

Return To School 1 Year After Traumatic Brain Injury: A Study Using The Traumatic Brain Injury Model Systems National Database, Kathryn Tarnai

Masters Theses, 2020-current

For many individuals, recovery from moderate to severe brain injuries involves returning to a level of pre-injury productivity. Specifically, previous research has focused extensively on factors predicting return to employment, where students are inconsistently categorized with those in competitive employment. Moreover, research dedicated to return to school for students in secondary and tertiary education is largely qualitative; very few studies have utilized predictive modeling on a sample composed solely of students. For this study, a model including days of post-traumatic amnesia (PTA), length of stay (LOS), rehabilitation discharge Disability Rating Scale (DRS) scores, and educational level was used to predict …

Bk Virus Nephropathy: Prevalence, Impact And Management Strategies, Rajeev Sharma, Mareena Zachariah

School of Medicine Faculty Research

BK virus reactivation as a result of therapeutic immunosuppression following renal transplant can result in BK polyomavirus nephropathy and renal allograft loss. This is a complex and challenging clinical problem with a range of management options and practices reported in literature. The current standard for early diagnosis and treatment is surveillance by measuring viral DNA in blood using qPCR. Immunosuppression reduction is the cornerstone of effective management but is associated with a risk of acute rejection following treatment.

Con Confianza: Using Community-Based Participatory Research Principles To Inform Community-Academic Partnership Practices And Build Trust In Hispanic Communities, Sharon Tafolla

Master's Projects and Capstones

Hispanic communities are at disproportionate risk for chronic diseases and researchers have cited the need for further community and culturally informed studies to improve research outcomes to either make treatments and interventions more generalizable or modify them to the needs of Hispanic communities. However, many of the same linguistic and cultural barriers to health care access and utilization also impact the ability for Hispanic groups to participate in research studies. Community Academic Partnerships (CAPs) are positioned to conduct culturally and linguistically competent research in Hispanic communities. For research in Hispanic communities to be effective, CAPs must prioritize practices that build …

Program Evaluation: Bring Change To Mind High School Club, Rachel Goldberg

Master's Projects and Capstones

Introduction. Mental illness (MI) stigma is common and causes adverse consequences such as reduced self-esteem and discrimination in housing and employment. Bring Change to Mind (BC2M), a national non-profit organization, strives to reduce this stigma through their high school club program. The evaluation goals were to assess the program’s operations and measure club members’ and advisors’ attitudes and perceptions around mental health (MH) and MI.

Methods. Qualtrics surveys were used to gather information from general club members (GCMs) (N=645), club advisors (N=97), and graduating seniors (N=57). BC2M staff held 52 small group discussions with club leaders. Data analysis was conducted …

Examining The Efficacy Of Web-Based Quality Improvement Hand Hygiene Education In Reducing Post-Cesarean Birth Surgical Site Infection, Lilian Allen

Grace Peterson Nursing Research Colloquium

Abstract

Objective: This is a quality improvement project aimed to evaluate the effectiveness of an educational training initiative on hand-hygiene (HH) for health care providers in women's health department to identify learning needs, behaviors, and attitudes.

Design: A descriptive, prospective, longitudinal design, using baseline data collection points before the web-based intervention was introduced (time 0), immediately after the web-based intervention completion (time 1), one to six weeks after completion of the intervention (time 2).

Setting: A Chicagoland area tertiary care hospital.

Participants: Clinical staff of the women's care center, which included the Labor and Delivery, Mother and Baby, and …

Use Of Fiberoptic Intubation Simulation To Enhance Skill And Confidence Among Anesthesia Providers, Fredrich F. Raz, Kris Toribio

Grace Peterson Nursing Research Colloquium

Abstract

Background: The purpose of this study was to describe the usefulness of a video-recorded low-fidelity Fiber Optic (FO) intubation simulation and its effect on anesthesia providers’ confidence and skill in performing FO intubation.

Method: The study was conducted during the 2019 IANA Airway Workshop using a post-test only study design. All participants who volunteered to participate in the simulation were asked to watch a video-recorded instruction on FO intubation. Immediately after viewing the video, the participants completed a hands-on simulation while the researchers recorded their FO intubation times. Participants were allowed up to three recorded attempts.

Results: Fifty-eight participants …

An Examination Of Certified Nurse-Midwives' Attitudes And Beliefs Surrounding Breastsleeping: Implications For Advanced Nursing Practice And Education, Lucy Mueller Wiesemann

Grace Peterson Nursing Research Colloquium

An Examination of Certified Nurse-Midwives' Attitudes and Beliefs Surrounding Breastsleeping: Implications for Advanced Nursing Practice and Education

Lucy Mueller Wiesemann, DNP, CNM, APN, CLS; DePaul University, Chicago, IL

Abstract

Introduction: Breastsleeping, defined as cosleeping while breastfeeding, is a practice commonly employed in breastfeeding families. However, literature examining this concept, its prevalence, and related education for safe breastsleeping is scant. Provider’s attitudes surrounding breastsleeping play an essential role in practice and outcomes when caring for breastfeeding patients and families. The purpose of the study was to examine Certified Nurse-Midwives’ attitudes and beliefs surrounding breastsleeping.

Methods: An adapted 18-item Nurse Attitudes and …

Self-Management And Quality Of Life In Young Adults After Healthcare Transition, Jennifer Herbert

Grace Peterson Nursing Research Colloquium

The transition from pediatric to adult healthcare has become healthcare concern of increasing importance as more adolescents with chronic conditions survive to adulthood requiring continuing care. In order to understand the current status of healthcare transition (HCT), we identified the HCT services received by young adults, their existing healthcare self-management skills and how skills correlated with their quality of life. A correlational and retrospective cross-sectional online survey of English-speaking young adults in the United States ages 18-26 with at least one pediatrically diagnosed chronic condition was conducted August-October 2019. Participants completed a healthcare transition feedback survey, the TRANSITION-Q self-management skills …

Implementing Positive Language In Anesthesia: Utilizing The Comfort Scale, Elisabeth Prehm, Tricia Oakes

Grace Peterson Nursing Research Colloquium

Implementing Positive Language in Anesthesia: Utilizing the Comfort Scale

Tricia Oakes & Elisabeth Prehm

Faculty Sponsor: Pamela Schwartz DNP, CRNA

Background

Verbal numeric pain scales (ranking pain on a scale from zero to ten) are widely utilized and taught in medicine. Evidence-based research has shown that verbal numeric comfort scales are associated with a decrease in opioid administration, improved pain perceptions, and overall better patient satisfaction .7

Objective

The purpose of this study is to assess the impact of a video-based educational tool demonstrating the use of a comfort scale in the perioperative setting among Nurse Anesthesia Trainees (NATs), and …

Malignant Hyperthermia Simulation, Michael D. Quidort, Rachael K. Tse

Grace Peterson Nursing Research Colloquium

Malignant Hyperthermia Simulation

Rachael Tse, BSN, RN and Michael Quidort, BSN, RN

Faculty Sponsor: Anne Sauri, CRNA, DNP and Julia Feczko, CRNA, DNP

Background: Malignant hyperthermia (MH) is a life-threatening condition in which survival is highly dependent on early recognition and prompt treatment. The purpose of this DNP project was to examine the impact of an in vivo high-fidelity malignant hyperthermia simulation on CRNA confidence in crisis management.

Objectives: Does a high-fidelity simulation training exercise improve CRNAs’ confidence in identifying signs and symptoms during a MH crisis? Does a simulation-based training exercise improve CRNAs’ confidence in the management of a …

The Effects Of Guided Meditation On The Stress Levels Of Student Registered Nurse Anesthetists, Olivia Nassoiy, Abigail Hadley

Grace Peterson Nursing Research Colloquium

Background: Student Registered Nurse Anesthetists (SRNAs) cope with both academic and clinical stressors which can lead to an increase in stress, anxiety and depression. ¹ The literature demonstrates that guided meditation is a useful tool that can be integrated into daily life to help decrease stress and improve well-being. ²

Objectives: The purpose of this DNP project was to describe the level of stress among SRNAs and examine the relationship between a guided meditation intervention and self-reported stress, depression, wellness, and self-efficacy among second year SRNAs.

Method: The participants were second year anesthesia students attending NorthShore University School of Nurse …

Evaluation Of Health And Wellness Education Components, Modalities And Timing On Srna Self Efficacy And Coping, Jessica Rogers, Amanda Hemple

Grace Peterson Nursing Research Colloquium

Background: Health and wellness education is touted as a tool for improved self-efficacy and coping for student registered nurse anesthetists but the details of the effectiveness remain unclear. Objectives: Evaluate effects of content, modalities and timing of health and wellness education on the self efficacy and coping mechanisms of students in a nurse anesthesia training program. Method: Survey responses from 159 participants were collected online. Participants identified their General Self-Efficacy Score (GSE), Brief COPE score, average daily stress, health and wellness education components and the timing and modalities in which they were delivered, and if they assessed their education as …

Crnas And Sugammadex Use: A Qualitative Analysis, Natalia Izquierdo Bsn, Rn, Emily Mancewicz Bsn, Rn

Grace Peterson Nursing Research Colloquium

Background: The availability of Sugammadex has increased options for Certified Registered Nurse Anesthetists’ (CRNAs) and their choice of neuromuscular reversal agents, however administration is impacted by a variety of provider and institutional factors.

Objectives: The purpose of this study was to examine and describe the personal and institutional factors impacting the use of Sugammadex in Illinois by CRNAs.

Method: A qualitative study design using an open-ended survey yielded 209 responses. The three main themes that emerged were 1) Why CRNAs choose to use or avoid Sugammadex 2) How CRNAs dose Sugammadex and 3) Practice variations existing within the clinical setting. …