Medicine and Health Sciences Commons^™

Intrarenal Renin Angiotensin System Imbalance During Postnatal Life Is Associated With Increased Microvascular Density In The Mature Kidney, Carolina Dalmasso, Alejandro R. Chade, Mariela Mendez, Jorge F. Giani, Gregory J. Bix, Kuey Chu Chen, Analia S. Loria

Pharmacology and Nutritional Sciences Faculty Publications

Environmental stress during early life is an important factor that affects the postnatal renal development. We have previously shown that male rats exposed to maternal separation (MatSep), a model of early life stress, are normotensive but display a sex-specific reduced renal function and exacerbated angiotensin II (AngII)-mediated vascular responses as adults. Since optimal AngII levels during postnatal life are required for normal maturation of the kidney, this study was designed to investigate both short- and long-term effect of MatSep on (1) the renal vascular architecture and function, (2) the intrarenal renin-angiotensin system (RAS) components status, and (3) the genome-wide expression …

Empirical Fluoroquinolones Versus Broad-Spectrum Beta-Lactams For Gram-Negative Bloodstream Infections In The Absence Of Antimicrobial Resistance Risk Factors, Majdi N. Al-Hasan, Alyssa P. Gould, Chelsea Drennan, Olivia Hill, Julie Ann Justo, Joseph Kohn, P Brandon Bookstaver

Faculty Publications

OBJECTIVES: Increasing antimicrobial resistance rates limit empirical antimicrobial treatment options for Gram-negative bloodstream infections (GN-BSI). However, antimicrobial resistance may be predicted based on patient-specific risk factors using precision medicine concepts. This retrospective, 1:2 matched cohort examined clinical outcomes in hospitalized adults without major risk factors for antimicrobial resistance receiving empirical fluoroquinolones or broad-spectrum beta-lactams (BSBL) for GN-BSI at Prisma Health-Midlands hospitals in Columbia, SC, USA from January 2010 through June 2015. METHODS: Multivariable logistic regression was used to examine early treatment failure at 72-96 h from GN-BSI. Cox proportional hazards regression was used to examine 28-day mortality and hospital length …

Views That Matter: Race And Opinions On Climate Change Of Boston Area Residents, Lorena M. Estrada-Martínez, Paul Watanabe, Katsyris Rivera-Kientz

Sustainable Solutions Lab

A growing body of research finds that climate change places a disproportionate burden on communities of color in the United States. In spite of this evidence, important discussions taking place about climate change- such as how it is experienced, which policy solutions are most critical, and how we can prepare for and adapt to its impacts- often leave out the voices of the very communities most affected. In Massachusetts, for instance, numerous statewide surveys have gathered information about residents ' attitudes and beliefs about climate change, but to date, no studies have been designed to include the views of a …

Cerebral Cavernous Malformation Presenting As Seizures, Hazim Brohi, Ayisha Farooq, Bushra Rehan, Muhammad Mairaj Khan

Pakistan Journal of Neurological Sciences (PJNS)

Cerebral cavernous malformations (CCMs) is one of the rare vascular malformation. It is diagnosed by characteristic lesions on magnetic resonance imaging (MRI). CCMs typically appears as a “popcorn-like” masses on T2-weighted images on MRI studies.And clinically can lead to headaches, seizures,focal neurological deficits or intracerebral hemorrhages. . A familial form is suggested if lesions are multiple, and a sporadic form, if single

Urdu Translation And Validation Of Premature Ejaculation Diagnostic Tool (Pedt), Muhibullah Bangash, Wajahat Aziz, Mohammad Shoaib, Hammad Ather

Section of Urology

Objective: To validate an Urdu translation of premature ejaculation diagnostic tool (PEDT) by analyzing the association of this diagnostic tool with the clinical diagnosis of premature ejaculation (PE) and intravaginal ejaculatory latency time (IELT).
Methods: This cross-sectional study was conducted at the urology section of the Aga Khan University Hospital, Karachi, for six months duration, from July 2018 to December 2018. In our study 108 subjects, aged 20 to 50 years, who were in a stable sexual relationship (heterosexual) for a minimum duration of six months, were asked to fill the Urdu version of PEDT, 61 with PE and 47 …

Pregnancy Cohorts And Biobanking In Sub-Saharan Africa: A Systematic Review, Jeffrey N. Bone, Kelly Pickerill, Mai-Lei Woo Kinshella, Marianne Vidler, Rachel Craik, Lucilla Poston, William Stones, Esperanca Sevene, Marleen Temmerman, Angela Koech

Obstetrics and Gynaecology, East Africa

Background: Technological advances and high throughput biological assays can facilitate discovery science in biobanks from population cohorts, including pregnant women. Biological pathways associated with health outcomes differ depending on geography, and high-income country data may not generalise to low-resource settings. We conducted a systematic review to identify prospective pregnancy cohorts in sub-Saharan Africa (SSA) that include biobanked samples with potential to enhance discovery science opportunity.

Methods: Inclusion criteria were prospective data collection during pregnancy, with associated biobanking in SSA. Data sources included: scientific databases (with comprehensive search terms), grey literature, hand searching applicable reference lists and expert input. Results were …

The Influence Of Empowerment On The Development Of Compassion Fatigue In Oncology Nurses, Franklin J. Wynn

Nursing Theses and Dissertations

Compassion fatigue is a growing issue in the oncology nursing population that has implications on outcomes such as job satisfaction and intention to leave a job. With an increased need for nurses nationally, compassion fatigue needs to be further studied to identify solutions that support the retention of the oncology nursing workforce. The concept of empowerment has been favorable in leading to proactive workplace behaviors and attitudes. However, literature showed underrepresentation of this variable in relationship to compassion fatigue. A program of research in connection to these variables is provided. A comparative concept analysis on burnout and compassion fatigue is …

Quality Of Acid-Preserved Edamame Soybean At Immature And Mature Stages, David Octor Moseley, Leandro Mozzoni, Moldir Orazaly, Liliana Florez-Palacios, Pengyin Chen

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Edamame is a food-grade soybean that is harvested at the green-immature stage (R6) and sold fresh or frozen for consumption after steaming or boiling. Limited studies have been conducted on high-temperature sterilization of edamame in cans and on acid preservation of edamame. The objectives of this study were to evaluate the color retention and texture of edamame when pasteurized in acidic brine as compared to boiling, to assess the effect of sucrose and turmeric addition on acid-treated edamame, and to characterize varietal differences when edamame lines were pasteurized in an acidic brine at either R6 or R8 stage. All studies …

21 In The 21st—An Evaluation Of The Tobacco Regulation Trend, Casey Kellum

St. Mary's Law Journal

Tobacco regulation persists as a controversial issue both legally and politically in the United States. Throughout American history, states rely on local legislation to provide adequate protection to consumers of tobacco products, as “Big Tobacco” targets consumers for its addictive product. One of the most recent amendments in this arena is the state by state decision to raise the minimum legal sales age for tobacco to twenty-one.

Despite rigorous regulation of tobacco products in the United States, however, tobacco remains the leading cause of preventable deaths in the country. These “Tobacco 21” ordinances come at a critical time when the …

Introducing Occupational Balance And Mindfulness-Based Stress Reduction To Women At The New Beginnings Center, Piper Cleveland

OTD Capstone Projects

The New Beginnings Center is a workout facility that provides coaching in nutrition, fitness, and health behaviors for women experiencing obesity in low socioeconomic classes. The purpose of this project was to enhance the current 12-week curriculum based on reserch and client feedback, as well as create a potfolio for the marketing team of evidence and testamonies. The two curriculum additions focused on stress reduction through occupational balance and mindfulness. In the "Schedule Redesign" class, we focused on the importance of finding maladaptive time use in their schedule (e.g. watching too much TV, laying in bed too long, etc.) and …

Hs-4100 - Global Health Issues, Jose Nanin

Open Educational Resources

This syllabus includes OER materials and college policies for a fully online course that takes a comprehensive look at global health issues. In this course, the assessment of health issues are analyzed from various perspectives including geographic, ethnic, religious, human rights, socioeconomic, social, cultural, and political influences. Students learn about global environmental causes and consequences of infectious diseases, major diseases, mental illness, natural disasters, malnutrition, drug and alcohol addiction, violence and injuries.

Coh-2000 - Community Health Interventions, Jose Nanin

Open Educational Resources

This syllabus includes OER materials and college policies for a fully online course that exposes students to a range of health promotion and disease prevention and management strategies used by health specialists to address community health challenges. Through readings and videos, as well as online course assignments and discussions, students learn about planning and designing interventions to improve the health of specific priority populations and communities-at-large.

Modeling The Impact Of Inclusion Of Family Planning Services In Ghana's National Health Insurance Scheme, Justin Archer, Gillian Eva, Augustine Ankomah, Saumya Ramarao, Kamil Fuseini, Anne Coolen, Stephen Duku, Benjamin Bellows

Reproductive Health

While access to and uptake of modern family planning (FP) in Ghana has steadily risen over the last decade, the modern Contraceptive Prevalence Rate (mCPR) among all women reached only 22% in 2019 with 30% of women still reporting unmet need. To increase FP uptake via mitigation of cost barriers among women with unmet need, the Government of Ghana is seeking to integrate claims-based FP services into the National Health Insurance Scheme benefits package. The impact of these activities has the potential to be significant with the proportion of women accessing modern FP shifting dramatically to public facilities over the …

Documenting Lessons From An Integrated Social And Behavior Change Program Linked To Integrated Health Services In Zambia, Breakthrough Research

Reproductive Health

This program brief documents lessons for social and behavior change programmers implementing multi-health, community-based programs with integrated health services. An iterative process by Breakthrough ACTION Zambia, from October 2018 through March 2019, identified four design concepts with strong feasibility and potential for impact and expansion. These four concepts were refined in Breakthrough ACTION Zambia provinces and districts in collaboration with implementing partners and the Ministry of Health Department of Health Promotion, with final intervention design and implementation processes determined in close collaboration with the Ministry.

A Smartphone-Based Support Group For Alcoholism: Effects Of Giving And Receiving Emotional Support On Coping Self-Efficacy And Risky Drinking, Woohyun Yoo, Dhavan V. Shah, Ming-Yuan Chih, David H. Gustafson

Health and Clinical Sciences Faculty Publications

The purpose of this study was to investigate the nature and effects of exchanging emotional support via a smartphone-based support group for patients with alcohol dependence. Of the 349 patients who met the Diagnostic and Statistical Manual of Mental Disorders (4th ed.) criteria for alcohol dependence, 153 patients participated in the discussion group within the Addiction-Comprehensive Health Enhancement Support System, a smartphone application aimed at reducing relapse. This was developed to prevent problem drinking by offering individuals in recovery for alcohol dependence automated 24/7 recovery support services and frequent assessment of their symptom status as part of their addiction care. …

Mindful Matters: Addressing Barriers To Classroom-Based Mindfulness, Kirsten Munk

Doctoral Projects

A growing body of research suggests that incorporating classroom-based mindfulness interventions in elementary schools is associated with improvements in student behavior, self-regulation, and measures of mental health. However, the adoption of teacher-led mindfulness programs in California’s public schools has not been widely embraced. This doctoral project explored the impact of an educational intervention on pre-service teachers’ perceptions, attitudes, and intentions to implement mindfulness interventions in their classrooms. A brief educational intervention and website resource were provided to multidisciplinary teaching credential students in a 2-year graduate credential program. Participants completed a pre- and post-intervention survey to evaluate their intentions to implement …

Redesigning The Landscape For Women And Leadership: Insights Gained From The Covid-19 Pandemic. On Behalf Of Women In Gastroenterology Network Asia Pacific (Wignap) And Women In Endoscopy (Wie), Lubna Kamani, Nonthalee Pausawasdi, Jeanin E Van Hooft, Amrita Sethi, Sharmila Sachithanandan

Section of Gastroenterology

No abstract provided.

J Mich Dent Assoc September 2020

The Journal of the Michigan Dental Association

Every month, The Journal of the Michigan Dental Association brings news, information, and features about Michigan dentistry to our state's oral health community and the MDA's 6,200+ members. No publication reaches more Michigan dentists!

In this issue, the reader will find the following original content:

• A cover story, “Perspectives from the Deans: Michigan’s Dental Schools in the Time of COVID-19"
• Five feature stories: “There’s a New CDA-to-RDA Pathway in West Michigan”, “We Can Do Something to Meet the Need for More RDAs”, “Coronavirus in the Workplace: Frequently Asked Questions and Answers”, “Statistics Tutorial Part IV: Common Statistical Errors”, and “Preparing …

Building Focused Cardiac Ultrasound Capacity In A Lower Middle-Income Country: A Single Centre Study To Assess Training Impact, Wangari Siika, Anders Barasa, Benjamin Wachira, David Nekyon, Barbara Karau, Fatimah Juma, Grace Wanjiku, Harun Otieno, Gerald S. Bloomfield, Erik Sloth

Anaesthesiology, East Africa

Background: In low- and middle-income countries (LMICs) where echocardiography experts are in short supply, training non-cardiologists to perform Focused Cardiac Ultrasound (FoCUS) could minimise diagnostic delays in time-critical emergencies. Despite advocacy for FoCUS training however, opportunities in LMICs are limited, and the impact of existing curricula uncertain. The aim of this study was to assess the impact of FoCUS training based on the Focus Assessed Transthoracic Echocardiography (FATE) curriculum. Our primary objective was to assess knowledge gain. Secondary objectives were to evaluate novice FoCUS image quality, assess inter-rater agreement between expert and novice FoCUS and identify barriers to the establishment …

Survey Of Airflow Around A Heated Manikin As A Simulated Aeromedical Evacuation Patient On A Litter With Computational Fluid Dynamics Models, George P. Lemmer

Theses and Dissertations

Aeromedical Evacuations remain the predominant method used to transport patients from forward deployed areas of operations to secure locations with more robust medical infrastructure. Transportation of chemical warfare casualties and infectious patients require additional attention to prevent cross contamination. Specific airflow characteristics paired with environmental control system settings are a gap in scholarly literature. Based on the available literature computational fluid dynamics models were created to simulate the airflow around a patient represented by human geometry using commercially available software. In order to compare simulated and experimental results a heated manikin was placed in the MURPHEE aerosol exposure chamber and …

Development Of A Semi-Quantitative Methodology For Evaluation Of Whole-Body Chemical, Biological, Radiological, And Nuclear Decontamination Using An Ultraviolet Fluorescent Aerosol, Emily M. Titus

Theses and Dissertations

This work describes a literature review which was conducted on publicly available literature on chemical, biological, radiological, and nuclear (CBRN) decontamination to understand the body of knowledge and gaps in this body of knowledge, including the assumption that disrobing after a CBRN incident will remove 90% of contamination. Also included is a description of the design and characterization of an aerosol test chamber which was constructed for use in this research. Finally, the bulk of this work describes the development of a semi-quantitative methodology for visualizing contamination. This method uses an ultraviolet fluorescent aerosol (to simulate contamination by a chemical …

Cinacalcet Studies In Pediatric Subjects With Secondary Hyperparathyroidism Receiving Dialysis., Bradley A. Warady, Eric Ng, Laura Bloss, May Mo, Franz Schaefer, Justine Bacchetta

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Secondary hyperparathyroidism (sHPT), a complication of chronic kidney disease (CKD) characterized by persistently elevated parathyroid hormone (PTH), alterations in calcium-phosphorus homeostasis, and vitamin D metabolism, affects 50% of children receiving dialysis. A significant proportion of these children develop CKD-mineral and bone disorder (CKD-MBD), associated with an increased risk of fractures and vascular calcification. The standard of care for sHPT in children includes vitamin D sterols, calcium supplementation, and phosphate binders. Several agents are approved for sHPT treatment in adults undergoing dialysis, including vitamin D analogs and calcimimetics, with limited information on their safety and efficacy in children. The calcimimetic …

Improved Tolerability Of Neratinib In Patients With Her2-Positive Early-Stage Breast Cancer: The Control Trial, C H Barcenas, R Bose, Et Al.

2020-Current year OA Pubs

BACKGROUND: Neratinib is an irreversible pan-HER tyrosine kinase inhibitor approved for extended adjuvant treatment in early-stage HER2-positive breast cancer based on the phase III ExteNET study. In that trial, in which no antidiarrheal prophylaxis was mandated, grade 3 diarrhea was observed in 40% of patients and 17% discontinued due to diarrhea. The international, open-label, sequential-cohort, phase II CONTROL study is investigating several strategies to improve tolerability.

PATIENTS AND METHODS: Patients who completed trastuzumab-based adjuvant therapy received neratinib 240 mg/day for 1 year plus loperamide prophylaxis (days 1-28 or 1-56). Sequential cohorts evaluated additional budesonide or colestipol prophylaxis (days 1-28) and …

Growth, Detection, Quantification, And Inactivation Of Sars-Cov-2, James Brett Case, Adam L. Bailey, Arthur S. Kim, Rita E. Chen, Michael S. Diamond

2020-Current year OA Pubs

Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 is the agent responsible for the coronavirus disease 2019 (COVID-19) global pandemic. SARS-CoV-2 is closely related to SARS-CoV, which caused the 2003 SARS outbreak. Although numerous reagents were developed to study SARS-CoV infections, few have been applicable to evaluating SARS-CoV-2 infection and immunity. Current limitations in studying SARS-CoV-2 include few validated assays with fully replication-competent wild-type virus. We have developed protocols to propagate, quantify, and work with infectious SARS-CoV-2. Here, we describe: (1) virus stock generation, (2) RT-qPCR quantification of SARS-CoV-2 RNA; (3) detection of SARS-CoV-2 antigen by flow cytometry, (4) quantification of infectious …

Adrenal Insufficiency Is A Contraindication For Omalizumab Therapy In Mast Cell Activation Disease: Risk For Serum Sickness, G J Molderings, L B Weinstock, Et Al.

2020-Current year OA Pubs

Omalizumab is an effective therapeutic humanized murine IgE antibody in many cases of primary systemic mast cell activation disease (MCAD). The present study should enable the clinician to recognize when treatment of MCAD with omalizumab is contraindicated because of the potential risk of severe serum sickness and to report our successful therapeutic strategy for such adverse event (AE). Our clinical observations, a review of the literature including the event reports in the FDA AE Reporting System, the European Medicines Agency Eudra-Vigilance databases (preferred search terms: omalizumab, Xolair®, and serum sickness) and information from the manufacturer's Novartis database were used. Omalizumab …

Conversations With Health Care Providers And Parents Before Autism Diagnosis: A Qualitative Study, Norah L. Johnson, Wendy Krueger, Elizabeth Jilek, Kristin Haglund

College of Nursing Faculty Research and Publications

Introduction

The purpose of this study was to explore communication with health care providers from the perceptions of parents before their child's diagnosis of autism spectrum disorder and provide some examples of how communication may contribute to the autism diagnosis.

Method

This study used a qualitative descriptive design with multiple individual structured in-person interviews.

Results

Three themes captured parents’ (n = 8) descriptions of the phases of communication during their children's diagnoses including, (1) anguished questioning, (2) urgently seeking help, and (3) expecting a diagnosis. In addition, three themes characterized the communication style that parents needed, although not always …

“No One Could Calm Him Down”: Mothers’ Experience Of Autism Diagnosis And Obtainment Of Resources In An Urban Public School District, Norah L. Johnson, Phonethip Sangasy, Karen Marie Robinson

College of Nursing Faculty Research and Publications

The purpose of this study was to explore the experience of accessing autism diagnosis and resources in a Midwest urban public school district for diverse mothers of children with autism spectrum disorder. Method: We employed thematic analysis using narrative inquiry methodology to analyze the data from 9 mothers (n = 5 African American, n = 2 Hispanic, and n = 2 White) who participated in a focus group. Results: Three themes were identified by the researchers: (a) late medical diagnosis (subthemes: problems that parents didn’t perceive as signs of autism spectrum disorder, making comparisons to other siblings or children), …

Evaluation Of Mechanical And Biocompatibility Properties Of Hydroxyapatite/Manganese Dioxide Nanocomposite Scaffolds For Bone Tissue Engineering Application, Fatemeh Azizi, Fatemeh Heidari, Farahnaz Fahimipour, Mohammad Sajjadnejad, Daryoosh Vashaee, Lobat Tayebi

School of Dentistry Faculty Research and Publications

The aim of this research was to evaluate the mechanical properties, biocompatibility, and degradation behavior of scaffolds made of pure hydroxyapatite (HA) and HA‐modified by MnO₂ for bone tissue engineering applications. HA and MnO₂ were developed using sol‐gel and precipitation methods, respectively. The scaffolds properties were characterized using X‐ray diffraction (XRD), Fourier transform spectroscopy (FTIR), scanning electron microcopy (SEM), energy dispersive spectroscopy (EDS), and transmission electron microscopy (TEM). The interaction of scaffold with cells was assessed using in vitro cell proliferation and alkaline phosphatase (ALP) assays. The obtained results indicate that the HA/ MnO₂ scaffolds possess higher …

Engaging Parents In Education For Discharge (EPed): Evaluating The Reach, Adoption & Implementation Of An Innovative Discharge Teaching Method, Norah L. Johnson, Stacee M. Lerret, Carol Klingbeil, Michele Polfuss, Cori A. Gibson, Karen Gralton, Mauricio Garnier-Villarreal, Sheikh Iqbal Ahamed, Riddhiman Adib, Rachel Unteutsch, Louis Pawela, Rosemary White-Traut, Kathleen J. Sawin, Marianne E. Weiss

College of Nursing Faculty Research and Publications

Purpose

This paper describes the evaluation of the implementation of an innovative teaching method, the “Engaging Parents in Education for Discharge” (ePED) iPad application (app), at a pediatric hospital.

Design and methods

The Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework was used to guide the evaluation. Three of the five RE-AIM elements are addressed in this study: Reach, Adoption, and Implementation.

Results

The Reach of the ePED was 245 of 1015 (24.2%) patient discharges. The Adoption rate was 211 of 245 (86%) patients discharged in the five months' study period. High levels of fidelity (89.3%) to …

Berry Phenolic And Volatile Extracts Inhibit Pro-Inflammatory Cytokine Secretion In Lps-Stimulated Raw264.7 Cells Through Suppression Of Nf-Κb Signaling Pathway, Inah Gu, Cindi Brownmiller, Nathan Blaine Stebbins, Andy Mauromostakos, Luke Howard, Sun-Ok Lee

Food Science Faculty Publications and Presentations

Berries are a rich source of phytochemicals, especially phenolics well known for protective activity against many chronic diseases. Berries also contain a complex mixture of volatile compounds that are responsible for the unique aromas of berries. However, there is very limited information on the composition and potential health benefits of berry volatiles. In this study, we isolated phenolic and volatile fractions from six common berries and characterized them by HPLC/HPLC-MS and GC/GC-MS, respectively. Berry phenolic and volatile fractions were evaluated for an anti-inflammatory effect using lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells by measuring levels of pro-inflammatory cytokines and the nuclear factor-kappa …