Medicine and Health Sciences Commons^™

Accidental Snapping Of Right Ventricular Pacing Lead With Micra, Vivek Singh Guleria, Prafull Sharma, Prashant Bharadwaj

Journal of the Saudi Heart Association

Leadless pacemaker implantation rates are increasing worldwide. These pacemakers have to be deployed , captured and redeployed in order to achieve optimal electric parameters. Various complications occur during this procedure. We herein report a unique case, where right ventricular(RV) pacing lead of the patient was accidentally snapped during MICRA deployment in a elderly male with pocket site infection.

Effect Of Coronary Artery Bifurcation Angle On Atherosclerotic Lesion Localization Distance To The Bifurcation Site, Murat Ziyrek, Ahmet Lütfü Sertdemir, Mustafa Duran

Journal of the Saudi Heart Association

Objectives: Although percutaneous coronary interventions become a common treatment modality for coronary artery diseases, lesion localization make these procedures more complex. As the lesion localizes near to the bifurcation site, more complex PCI procedures, overqualified equipments are needed and complication risk increases. Previous studies have demonstrated the strong correlation between wide angulation and significant coronary stenosis. However, a paucity of data exists about the association between bifurcation angle and lesion localization distance. In this study we analysed the effect of coronary bifurcation angle and left main coronary artery length on the atherosclerotic lesion localization.

Methods: Patients, who underwent coronary angiography …

Naive Pluripotent Stem Cells Exhibit Phenotypic Variability That Is Driven By Genetic Variation., Daniel Ortmann, Stephanie Brown, Anne M Czechanski, Selcan Aydin, Daniele Muraro, Yuanhua Huang, Rute A Tomaz, Anna Osnato, Giovanni Canu, Brandon T Wesley, Daniel A Skelly, Oliver Stegle, Ted Choi, Gary A Churchill, Christopher L. Baker, Peter J Rugg-Gunn, Steven C. Munger, Laura G Reinholdt, Ludovic Vallier

Faculty Research 2020

Variability among pluripotent stem cell (PSC) lines is a prevailing issue that hampers not only experimental reproducibility but also large-scale applications and personalized cell-based therapy. This variability could result from epigenetic and genetic factors that influence stem cell behavior. Naive culture conditions minimize epigenetic fluctuation, potentially overcoming differences in PSC line differentiation potential. Here we derived PSCs from distinct mouse strains under naive conditions and show that lines from distinct genetic backgrounds have divergent differentiation capacity, confirming a major role for genetics in PSC phenotypic variability. This is explained in part through inconsistent activity of extra-cellular signaling, including the Wnt …

2020-09-03_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

The webpage was obtained from Michigan's Coronavirus Cumulative Data page, under the link Data About Places. Data is self-reported by hospitals daily to the EM Resource System per MDHHS Director Robert Gordon's Emergency Order.

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

2020-09-03_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …

2020-09-03_Michiganoverview_Covidoutbreak, Michigan Department Of Health & Human Services

Michigan COVID-19 Outbreak Reports

The Outbreak Data page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173_102057---,00.html.

This report is created by the Michigan Department of Health & Human Services from data self-reported by local health departments. Data is updated every week.

COVID-19 outbreaks are generally defined as two or more cases with a link by place and time indicating a shared exposure outside of a household. Local health departments report the number of new and ongoing outbreaks they are investigating by the setting of the outbreak. New outbreaks are those outbreaks that were first identified during the current reporting week. Ongoing outbreaks are …

2020-09-03_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services

Michigan COVID-19 Long Term Care Data

The COVID Long Term Care Facilities page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173-526911--,00.html.

This report is created by the Michigan Department of Health & Human Services from data self-reported by long-term care facilities into EMResource. Data is updated on an ongoing basis.

The data below represents a cumulative total of confirmed COVID-19 resident cases, cumulative total of suspected and confirmed resident deaths, cumulative total of confirmed COVID-19 staff cases, and cumulative total of suspected and confirmed staff deaths reported by SNFs in Michigan since January 1, 2020. Case numbers are provisional and may change as facilities correct …

2020-09-03_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) and rapid virus antigen detection point of care (POC) tests, look for current infection. Serology (antibody) tests are used to look for the possibility of previous infection.
Source: Michigan Disease Surveillance System (MDSS) and Vital Records

The website contained the tables …

Non-Steroidal Or Opioid Analgesia Use For Children With Musculoskeletal Injuries (The No Ouch Study): Statistical Analysis Plan., Anna Heath, Maryna Yaskina, Gareth Hopkin, Terry P Klassen, Christopher Mccabe, Martin Offringa, Petros Pechlivanoglou, Juan David Rios, Naveen Poonai, Samina Ali

Paediatrics Publications

BACKGROUND: Pediatric musculoskeletal injuries cause moderate to severe pain, which should ideally be addressed upon arrival to the emergency department (ED). Despite extensive research in ED-based pediatric pain treatment, recent studies confirm that pain management in this setting remains suboptimal. The No OUCH study consist of two complementary, randomized, placebo-controlled trials that will run simultaneously for patients presenting to the ED with an acute limb injury and a self-reported pain score of at least 5/10, measured via a verbal numerical rating scale (vNRS). Caregiver/parent choice will determine whether patients are randomized to the two-arm or three-arm trial. In the two-arm …

Click-Free Synthesis Of A Multivalent Tricyclic Peptide As A Molecular Transporter, Sumit Kumar, Dindyal Mandal, Shaima Ahmed El-Mowafi, Saghar Mozaffari, Rakesh Kumar Tiwari, Keykavous Parang

Pharmacy Faculty Articles and Research

The cellular delivery of cell-impermeable and water-insoluble molecules remains an ongoing challenge to overcome. Previously, we reported amphipathic cyclic peptides c[WR]₄ and c[WR]₅ consisting of alternate arginine and tryptophan residues as nuclear-targeting molecular transporters. These peptides contain an optimal balance of positive charge and hydrophobicity, which is required for interactions with the phospholipid bilayer to facilitate their application as a drug delivery system. To further optimize them, we synthesized and evaluated a multivalent tricyclic peptide as an efficient molecular transporter. The monomeric cyclic peptide building blocks were synthesized using Fmoc/tBu solid-phase chemistry and cyclization in the …

Sequential Complications Of Hypercalcemia, Necrotizing Granulomatous Vasculitis, And Aplastic Anemia Occurring In One Patient With Angioimmunoblastic T-Cell Lymphoma., Sriman Swarup, Jonathan Kopel, Kyaw Zin Thein, Kaiser Tarafdar, Khatrina Swarup, Seshadri Thirumala, Donald P Quick

Articles, Abstracts, and Reports

In this case report of a patient with angioimmunoblastic T-cell lymphoma (AITL), we describe the occurrence of three sequential complications that have been reported uncommonly in this disease subtype. Firstly, the patient developed hypercalcemia due to elevated 1,25-didydroxyvitamin D. Although hypercalcemia in AITL is not rare (1-2% incidence), this case was unusual in that the complication developed when disease appeared stable and symptomatically, he was doing well otherwise. Hypercalcemia surprisingly resolved a few months later at a time when his disease appeared to be progressing. A year later, the patient presented with digital ischemia necessitating partial amputation of a finger. …

Differential Rates Of Intravascular Uptake And Pain Perception During Lumbosacral Epidural Injection Among Adults Using A 22-Gauge Needle Versus 25-Gauge Needle: A Randomized Clinical Trial, Robin Raju, Michael Mehnert, David Stolzenberg, Jeremy Simon, Theodore Conliffe, Jeffrey Gehret

Department of Rehabilitation Medicine Faculty Papers

BACKGROUND: Inadvertent intravascular injection has been suggested as the most probable mechanism behind serious neurological complications during transforaminal epidural steroid injections. Authors believe a smaller gauge needle may lead to less intravascular uptake and less pain. Theoretically, there is less chance for a smaller gauge needle to encounter a blood vessel during an injection compared to a larger gauge needle. Studies have also shown smaller gauge needle to cause less pain. The aim of the study was to quantify the difference between a 22-gauge needle and 25-gauge needle during lumbosacral transforaminal epidural steroid injection in regards to intravascular uptake and …

Current Challenges Of Digital Health Interventions In Pakistan: Mixed Methods Analysis, Abdul Momin Kazi, Saad Ahmed Qazi, Nazia Ahsan, Sadori Khawaja, Fareeha Sameen, Muhammad Ayub Khan Mughal, Zabin Wajidali, Hussain Kalimuddin, Yasir Rauf, Fatima Mahmood

Department of Paediatrics and Child Health

Background: Digital health is well-positioned in low and middle-income countries (LMICs) to revolutionize health care due, in part, to increasing mobile phone access and internet connectivity. This paper evaluates the underlying factors that can potentially facilitate or hinder the progress of digital health in Pakistan.
Objective: The objective of this study is to identify the current digital health projects and studies being carried out in Pakistan, as well as the key stakeholders involved in these initiatives. We aim to follow a mixed-methods strategy and to evaluate these projects and studies through a strengths, weaknesses, opportunities, and threats (SWOT) analysis to …

Improving Dental Hygiene Students' Journal Writing, Susan Davide

Publications and Research

During the introductory semester of treating patients, students are in need of assistance and guidance throughout the assessment and treatment phases of patient care. As novice learners, there is little to no prior knowledge on writing a patient case study presentation. To assist and improve dental hygiene student writing of patient case journals, a scaffold assignment was created. Over the course of the semester students were required to submit five patient case studies in the form of a journal. Each journal had a writing focus with specific directions for each along with a detailed rubric; the final journal encompassing all …

Human Respiratory And Gut Microbiomes - Do They Really Contribute To Respiratory Health?, Juliana Durack, Claus T. Christophersen

Research outputs 2014 to 2021

© Copyright © 2020 Durack and Christophersen. Human gastrointestinal and respiratory tracts are colonized by diverse polymicrobial communities shortly after birth, which are continuously molded by environmental exposure. The development of the resident microbiota in early life is a critical factor in the maturation of a healthy immune system. Disturbances to the intricate relationship between environmental exposure and maturation of the infant microbiome have been increasingly identified as a potential contributor to a range of childhood diseases. This review details recent evidence that implicates the contribution of gut and airway microbiome to pediatric respiratory health.

Non-Pharmacologic Interventions For Pain And Sedation, Kayla Gleason Bsn, Rn, Cameron Keys Bsn, Rn, Lori King Bsn, Rn, Kim Ruiz Bsn, Rn

Patient Care Services / Nursing

No abstract provided.

Lipocalin-2 Deficiency May Predispose To The Progression Of Spontaneous Age-Related Adiposity In Mice, Keya Meyers, María López, Joanna Ho, Savannah Wills, Srujana Rayalam, Shashidharamurthy Taval

PCOM Scholarly Works

Lipocalin-2 (Lcn2) is an innate immune protein elevated by several orders of magnitude in various inflammatory conditions including aging and obesity. Recent studies have shown that Lcn2 is secreted by adipocytes in response to inflammation and is categorized as a new adipokine cross-linking innate immunity and metabolic disorders including obesity. However, the involvement of Lcn2 and its function during the progression of obesity is largely unknown. Recently, browning of white adipose tissue (WAT) has gained attention as a therapeutic strategy to combat obesity. Herein, we have shown that treatment of mature 3T3-L1 adipocytes with recombinant Lcn2 (rec-Lcn2) resulted in the …

Intermittent Pneumatic Compression For Venous Thromboembolism Prevention: A Systematic Review On Factors Affecting Adherence, Richard Greenall, Rachel E. Davis

Faculty Publications

OBJECTIVE: Venous thromboembolism (VTE) is a potentially fatal complication of hospitalisation. Intermittent pneumatic compression (IPC) is one approach to reducing the likelihood of a VTE. Adherence to IPC is known to be inadequate though the reasons for this remain unclear. This systematic review explores factors that affect adherence to IPC in the inpatient context. METHODS: Information sources-EMBASE, MEDLINE and PsycINFO were searched for literature between January 1960 and May 2019. Eligibility criteria-studies were included if they focused on inpatient care and examined factors affecting adherence to IPC devices. RESULTS: Included studies-a total of 20 out of 1476 studies were included. …

Strategies For Increasing Impact, Engagement, And Accessibility In Hiv Prevention Programs: Suggestions From Women In Urban High Hiv Burden Counties In The Eastern United States (Hptn 064), Jasmine A. Abrams, Michelle Odlum, Emily Tillett, Danielle Haley, Jessica Justman, Sally Hodder, Linda Vo, Ann O’Leary, Paula M. Frew

School of Public Health Faculty Research

Background: Merely having the tools to end HIV is insufficient. Effectively ending the epidemic necessitates addressing barriers that impede engagement in biomedical and behavioral prevention and wide scale implementation and utilization of existing interventions. This qualitative study identifies suggestions for increasing access to, engagement in, and impact of HIV prevention among women living in cities in high HIV burden counties in the eastern US. Methods: Data analyzed for the current study were collected via a qualitative sub-study within the HIV Prevention Trials Network Study 064 (HPTN 064), a multisite observational cohort study designed to estimate HIV incidence among women residing …

Use Of Core-Om As A Benchmarking Tool For Patient Outcomes At Counselling Psychology Units In Malaysian Government Hospitals, Norainee Kamaruddin

Student Works (2020-2029)

The study aimed to use an alternative method of assessing client outcomes, and service performance by using the outcome measure—Clinical Outcomes in Routine Evaluation (CORE-OM). Presently, the counselling psychology unit assesses the clients' outcomes by subjective observations and clients' self-reports. As for service performance, the counselling psychology units are assessed internally by each hospital's management system. In advanced countries, these methods have been replaced or augmented by standardised routine outcome measures. This study used CORE-OM to measure client outcomes, and it was also the benchmarking tool to set service performance standards. It adopted a mixed-method research design using survey and …

Mindfulness Associated With Vicarious Trauma, Jennifer Grablewski Rn, Riley Schaeffer Bsn, Rn

Patient Care Services / Nursing

No abstract provided.

Improving Violent Restraint Documentation Compliance, Mary Toolen Rn, Jamie Mayeresky Bsn, Rn

Patient Care Services / Nursing

No abstract provided.

Caring For You And Your Smile Oral Hygiene Education At The Bedside, Julia Snyder Bsn, Rn, Gabriel Velez Bsn, Rn, Kenneth Zamarripa Rn

Patient Care Services / Nursing

No abstract provided.

Continuous Lateral Rotation—Time To Turn, Steven Adoff Bsn, Rn, Nicole Compano Rn, Ariel Danziger Rn, Allison Bunk Bsn, Rn

Patient Care Services / Nursing

No abstract provided.

Improving Documentation Of Is And Os In Chf Patients, Lauren Biege Bsn, Rn, Adam Braun Msn, Rn, Stephanie Figueroa Adn, Rn

Patient Care Services / Nursing

No abstract provided.

Child Abuse Screening As A Triage Nurse In The Emergency Department, Yaranis Abud Bsn, Rn, Thomas Antenuci Bsn, Rn, Katahdin Brown Rn, Jaclyn Hammill Bsn, Rn, Anna Kellaher Bsn, Rn, Cassandra Miller Rn

Patient Care Services / Nursing

No abstract provided.

Burn Buddies: A Teamwork Approach, Joshua Ashmar Bsn, Rn, Julie Gardner Rn, Andrea Santiago Rn, Amanda Wills Bsn, Rn

Patient Care Services / Nursing

No abstract provided.

Bedside Shift Report In The Emergency Department, Abagail Schneck Bsn, Rn, Rachel Slane Bsn, Rn, Victoria Sneeringer Bsn, Rn, Brianna Lange Bsn, Rn, Kaitlyn Willis Bsn, Rn

Patient Care Services / Nursing

No abstract provided.

Glucose Management, Dushaun Blackwood Bsn, Rn, Lori Holliday Adn, Rn, Christina Peyroux Bsn, Rn, Kelsey Phillips Bsn, Rn

Patient Care Services / Nursing

No abstract provided.

Palliative Care Screening Tool Implementation In Progressive Care Units, Amanda Weiss-Raup Bsn, Rn, Jaclyn Onuschak Rn, Sheena Davis Bsn, Rn, Tracy Beck-Briggs Rn, Kyla Kaczkurkin Bsn, Rn

Patient Care Services / Nursing

No abstract provided.