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2020

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Articles 301 - 330 of 21840

Full-Text Articles in Medicine and Health Sciences

Plasma Flow Distal To Tourniquet Placement Provides A Physiological Mechanism For Tissue Salvage, Emily Busse, Cheryl Hickey, Nicole Vasilakos, Kennon Stewart, Fred O’Brien, Jessica Rivera, Luis Marrero, Michelle Lacey, Rebecca Schroll, Keith Van Meter, Mimi C. Sammarco Dec 2020

Plasma Flow Distal To Tourniquet Placement Provides A Physiological Mechanism For Tissue Salvage, Emily Busse, Cheryl Hickey, Nicole Vasilakos, Kennon Stewart, Fred O’Brien, Jessica Rivera, Luis Marrero, Michelle Lacey, Rebecca Schroll, Keith Van Meter, Mimi C. Sammarco

School of Medicine Faculty Publications

Military literature has demonstrated the utility and safety of tourniquets in preventing mortality for some time, paving the way for increased use of tourniquets in civilian settings, including perioperatively to provide a bloodless surgical field. However, tourniquet use is not without risk and the subsequent effects of tissue ischemia can impede downstream rehabilitative efforts to regenerate and salvage nerve, muscle, tissue and bone in the limb. Limb ischemia studies in both the mouse and pig models have indicated not only that there is residual flow past the tourniquet by means of microcirculation, but also that recovery from tissue ischemia is …


Use Of A Smartphone Ecg Monitor To Identify Electrocardiogram Abnormalities Due To Hyperkalemia From Urinary Obstruction In A Jacob’S Sheep, Joseph Smith Dec 2020

Use Of A Smartphone Ecg Monitor To Identify Electrocardiogram Abnormalities Due To Hyperkalemia From Urinary Obstruction In A Jacob’S Sheep, Joseph Smith

Faculty Publications and Other Works -- Large Animal Clinical Sciences

Smartphone-based ECGS present a diagnostic opportunity for large animal practice. A two year old Jacob’s sheep presented with severe hyperkalemia secondary to a urinary obstruction. Collection of an electrocardiogram from a smart-phone based device demonstrated altered waveforms typical of severe hyperkalemia. The patient was successfully managed with medical and surgical therapies. This case presents that the method of collecting a smartphone-based ECG as determined for other large animal species, may be applicable to sheep. Additionally, this report demonstrates that the smartphone-based device may be sensitive enough to detect the absence of a P wave as commonly encountered with cases of …


Week Of December 21, 2020, New York Medical College Dec 2020

Internal Medicine Point Of Care Ultrasound In The 21st Century: A ‘Focus’ On The Middle East, Arif Hussain, Irene W.Y. Ma Dec 2020

Internal Medicine Point Of Care Ultrasound In The 21st Century: A ‘Focus’ On The Middle East, Arif Hussain, Irene W.Y. Ma

Journal of the Saudi Heart Association

No abstract provided.


2020-12-20_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services Dec 2020

2020-12-20_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …


Budd-Chiary Syndrome Paper.Docx, Tarik Michael Dec 2020

Budd-Chiary Syndrome Paper.Docx, Tarik Michael

Sonography Faculty Scholarship

AbstractBudd-Chiari Syndrome is a pathology of the liver caused by obstruction of the hepatic veins. This disease is rare in the USA and more common in Asia, which is a good reason to misdiagnose and unable to provide adequate and timely treatment to such patients. Delay in making a diagnosis of such a disease might lead to complications and cost the life of the patient. In this paper, the definition, etiology, clinical manifestation, laboratory values, method of diagnosis, treatment and follow-up methods of the disease are included.


Perioperative Advanced Directives, Derek Washer Dec 2020

Perioperative Advanced Directives, Derek Washer

Doctor of Nursing Practice Projects

Technology and surgical techniques continue to improve, resulting in more clients with advanced directives presenting to the operative suite for surgery or procedures requiring anesthesia. Anesthesia providers are in a critical position to discuss with the surgical patient or surrogate any alteration or reconsideration to their advanced directive. Unfortunately, patients and anesthesia provider discussions at a North Texas hospital were limited due to a knowledge deficit, an outdated hospital policy rescinding all directives perioperatively, and an inadequate consenting mechanism. The perioperative advanced directives project involved updating the hospital policy to current national guidelines and developing a “DNR Under Anesthesia” consenting …


Program Evaluation Of The Vapro Touch-Free Hydrophilic Intermittent Catheter In Hospitalized Patients Experiencing Urinary Retention, Dorothy Neufeld Dec 2020

Program Evaluation Of The Vapro Touch-Free Hydrophilic Intermittent Catheter In Hospitalized Patients Experiencing Urinary Retention, Dorothy Neufeld

Doctor of Nursing Practice (DNP) Manuscripts

Abstract

A 319-bed hospital on the Florida Gulf coast revised their Bladder Care Bundle policy in September 2020. The document provided an algorithm to be followed to determine if intermittent urinary catheterization is warranted rather than an indwelling catheter to relieve urinary retention. Concurrently, this change included the introduction of a new product, Hollister’s VaPro Touch-Free Hydrophilic Intermittent Catheter which is considerably different from the traditional straight intermittent catheter previously utilized by the hospital. Its protective sheath and inducer tip are purported by the manufacturer to decrease the chance of contamination during insertion and thus reducing infection rates. A program …


The Importance Of Nutrition Education As A Recovery Component For Individuals With Severe Mental Illnesses, Emily Martinez Dec 2020

The Importance Of Nutrition Education As A Recovery Component For Individuals With Severe Mental Illnesses, Emily Martinez

Master's Projects and Capstones

In efforts to challenge the Western medicine’s determination of nutrition as a holistic approach, this paper represents the intent for mental health facilities in California to improve or implement nutrition education curriculum by enhancing interprofessional teams with dietitians as an important component of recovery for severe mental illness patients. There is concrete evidence proving that individuals who are in facilities recovering from mental illnesses have benefited from optimal nutrition consumption. Nutrition education has become a component among the toolbox of recovery options, but unfortunately it is not encouraged enough. Pharmaceutical companies advertise drug therapy as the most effective way to …


Lipid Peroxidation Inhibition Activity Of Sintrong (Crassocephalum Crepidioi-Des) Leaf Extract In Rats Consuming Arak Jembrana, Ni Putu Widayanti, Ayu Saka Laksmita W, Desak Putu Risky Vidika Apriyanthi, I G K Nyoman Arijana Dec 2020

Lipid Peroxidation Inhibition Activity Of Sintrong (Crassocephalum Crepidioi-Des) Leaf Extract In Rats Consuming Arak Jembrana, Ni Putu Widayanti, Ayu Saka Laksmita W, Desak Putu Risky Vidika Apriyanthi, I G K Nyoman Arijana

Makara Journal of Science

The present study was conducted to determine the antioxidant activity of sintrong (Crassocephalum crepidioides) leaf extract to inhibiting lipid peroxidation by decreased malondialdehyde (MDA) level in the blood plasma of rats consuming arak Jembrana. The process of making sintrong leaf extract used 96% ethanol with maceration techniques. In vivo testing used five groups: (1) a control group, (2) treatment with arak, (3) treatment with arak followed by extract at a dose of 37.5 mg/kgBW, (4) treatment with arak followed by extract at a dose of 50 mg/kgBW, and (5) treatment with arak followed by extract at a dose …


Mental Health In College Students: Disclosure & Seeking Support, Abby R. Smargon Dec 2020

Mental Health In College Students: Disclosure & Seeking Support, Abby R. Smargon

Honors Program Theses and Projects

A study was conducted through Bridgewater State University in order to better understand the mental health and help seeking behaviors of college students. The data collected served to provide information regarding what specific types of mental health difficulties are reported by college students.


Lemongrass (Cymbopogon Citratus) Ethanolic Extract Exhibited Activities That Inhibit -Glucosidase Enzymes And Postprandial Blood Glucose Elevation, Maria Dewi Puspitasari Tirtaningtyas Gunawan Puteri, Felicia Melissa Tjiptadi, Phebe Hendra, Filiana Santoso, Zalinar Udin, Nina Artanti, Florence Ignatia Florence Ignatia Dec 2020

Lemongrass (Cymbopogon Citratus) Ethanolic Extract Exhibited Activities That Inhibit -Glucosidase Enzymes And Postprandial Blood Glucose Elevation, Maria Dewi Puspitasari Tirtaningtyas Gunawan Puteri, Felicia Melissa Tjiptadi, Phebe Hendra, Filiana Santoso, Zalinar Udin, Nina Artanti, Florence Ignatia Florence Ignatia

Makara Journal of Science

Lemongrass is a common ingredient in Indonesian traditional herbal medicine that potently inhibits carbohydrate hydrolysis. In this study, the in vitro α-glucosidase inhibitory (AGI) activity of lemongrass was compared with its in vivo activity to retard postprandial blood glucose elevation, and the bioactive compounds responsible for these activities were observed. Both water and ethanolic extracts of lemongrass (WLG and ELG, respectively) were tested in vitro for its inhibition of the sucrose and maltose hydrolyzing activities of rat intestinal glucosidase. ELG was observed to exert higher inhibitory activities (Sucrase IC50 = 8.74 mg/mL; Maltase IC50 = 18.93 mg/mL) than …


Association Between Dietary Macronutrient Intake And High-Sensitivity C-Reactive Protein Levels Among Obese Women In Kuantan, Malaysia, Siti Zuhaidah Shahadan, Azlina Daud, Muhammad Ibrahim, Muhammad Lokman Md. Isa, Samsul Draman Dec 2020

Association Between Dietary Macronutrient Intake And High-Sensitivity C-Reactive Protein Levels Among Obese Women In Kuantan, Malaysia, Siti Zuhaidah Shahadan, Azlina Daud, Muhammad Ibrahim, Muhammad Lokman Md. Isa, Samsul Draman

Makara Journal of Science

Elevated high-sensitivity C-reactive protein (hs-CRP) levels may be associated with an increased risk of cardiovascular disease (CVD). In general, an individual’s dietary intake may influence the hs-CRP level. However, evidence on the influence of dietary macronutrient intake on hs-CRP levels among obese Malaysian women remains fragmented. Therefore, this study aims to investigate the association between the hs-CRP level and dietary macronutrient intake of obese adults living in Kuantan. The assessment of 24-hour dietary recall and venous hs-CRP levels were investigated in 67 women with a body mass index of 27.5 to 39.9 kg/m². The findings revealed that obese women living …


Using Drawings In Qualitative Interviews: An Introduction To The Practice, Alexios Brailas Dec 2020

Using Drawings In Qualitative Interviews: An Introduction To The Practice, Alexios Brailas

The Qualitative Report

Drawings are employed by qualitative researchers in many creative ways, and in many different contexts, and a variety of different terms are used to describe similar techniques. I present here a concise description of two basic approaches to integrating participants’ produced drawings into verbal qualitative research interviews, along with characteristic cases of empirical research demonstrating how these approaches have been applied. I also provide a list of best practices and I discuss ethical issues. It is common for qualitative researchers to mix techniques in order to creatively address real-world research challenges. The proposed categorization, augmented by the list of best …


Explicit Learning Of Auditory Categories In Preschoolers With And Without Developmental Language Disorder, Lauren Casey Dec 2020

Explicit Learning Of Auditory Categories In Preschoolers With And Without Developmental Language Disorder, Lauren Casey

University Honors Theses

This study a part of a broader study including Quam et al. (2020) and Yu (2020) with the aim of understanding how children with and without developmental language disorder learn language. With a better understanding of the underlying learning mechanisms affected in DLD, better interventions can be implemented. The current study investigates explicit language learning in preschoolers with and without developmental language disorder (DLD). This was done by observing sound discrimination and explicit sound-meaning mapping. One child with DLD and 29 children with typical language development (TLD) participated in this study. Inclusion in each group was determined by a hearing …


Imaging The Tumor Microenvironment Using 1,2-Dioxetane Chemiluminescence Agents, Lucas Ryan Dec 2020

Imaging The Tumor Microenvironment Using 1,2-Dioxetane Chemiluminescence Agents, Lucas Ryan

Chemistry Theses and Dissertations

As complex organisms, animals and humans rely on a delicate interplay between many connected systems to maintain proper cellular and whole-body function. Oxygen regulation and homeostasis are vital for proper function in healthy cells, as are core components of aerobic metabolism and efficient ATP generation to supply our energy needs. Maintaining pH homeostasis is also of primary importance; cells maintain pH homeostasis through a host of active and passive transporters to maintain pH balance both inside and outside of the cell.

Events of uncontrolled cellular proliferation, also known as cancer, survive and thrive under conditions that perturb the delicate balance …


2020-12-19_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services Dec 2020

2020-12-19_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …


Implementation And Program Evaluation Pilot Study: Educating Health Care Providers About Protecting Population Health During Climate Change., Christine Fasching Maphis Dec 2020

Implementation And Program Evaluation Pilot Study: Educating Health Care Providers About Protecting Population Health During Climate Change., Christine Fasching Maphis

Doctors of Nursing Practice (DNP) Final Projects, 2020-current

Recommendations regarding the need to prepare nurses and other health care providers (HCPs) for the health impacts of climate change (CC) have grown ubiquitous in the literature. Timely, efficient and sustainable strategies by the health care industry are necessary. Failure to act is predicted to result in catastrophic and lethal population health consequences. A growing body of research identifies related knowledge gaps and supports HCP competencies and best practice interventions to mitigate adverse population health impacts of CC. A social ecological framework and the PRECEDE-PROCEED approach were employed to develop and evaluate a series of online webinars designed to equip …


The Use Of Life-Like Robotic Animals In The Acute Care Setting To Assist In The Care Of Patients With Dementia, Abby Denby Dec 2020

The Use Of Life-Like Robotic Animals In The Acute Care Setting To Assist In The Care Of Patients With Dementia, Abby Denby

Doctors of Nursing Practice (DNP) Final Projects, 2020-current

The purpose of this pilot project was to describe the effect of life-like robotic animals on the nurses’ ability to provide care, patients’ level of agitation, use of antipsychotic medications, restraint and sitter use for patients with dementia in an acute care setting. Nurses report challenges and feelings of helplessness while caring for patients with dementia. Dementia may cause depression, agitation, aggression (physical or verbal) and a decrease quality of life. Animal Assisted Therapy (ATT) is a growing therapy in many healthcare settings but there is a lack of literature specifically related to the use of AAT in the acute …


What Methods Can The Health Care Industry Implement To Reduce Energy Consumption And Waste Production From Patient Care To Limit Greenhouse Gas Emissions?, Danielle H. S. Good Dec 2020

What Methods Can The Health Care Industry Implement To Reduce Energy Consumption And Waste Production From Patient Care To Limit Greenhouse Gas Emissions?, Danielle H. S. Good

Senior Honors Projects, 2020-current

Purpose: Climate change is a growing issue all around the world and has negative impacts on the environment and human health. The health care industry is a significant contributor to greenhouse gas emissions amplifying climate change. Health care establishments are in place to improve health but are inadvertently harming it at the same time. Methods:A review of the literature was conducted to determine the impact the health care industry has on climate change and what can be done to limit the impacts on the environment. Resources were collected from trusted organizations databases such as Healthcare Without Harm, …


Opioid Free Anesthesia, Sarah Medina Dec 2020

Opioid Free Anesthesia, Sarah Medina

Doctor of Nursing Practice Projects

Patients undergoing surgery are often given opioids intraoperatively. Administration of opioids is associated with untoward side effects that include nausea, respiratory depression, constipation, ileus, hyperalgesia, prolonged length of stay, and the potential for dependence (Garimella & Cellini, 2013). Emerging research on the topic of opioid-free anesthesia (OFA) is available and indicates several benefits of OFA, including reduction in postoperative pain, reduction in postoperative nausea and vomiting, reduction in postoperative shivering, and improved oxygen saturation levels (Mulier et al., 2018). This quality improvement project aimed to advance anesthesia providers' understanding of OFA by creating an OFA guideline and providing a learning …


2020-12-19_Michigandaily_Covidmap, Michigan Department Of Health & Human Services Dec 2020

2020-12-19_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …


Cultural Competency Training For U.S. Army Security Force Assistance Brigade (Sfab) Brigade Medical Teams, Jacob Blount Dec 2020

Cultural Competency Training For U.S. Army Security Force Assistance Brigade (Sfab) Brigade Medical Teams, Jacob Blount

Doctor of Nursing Practice Projects

The United States Army began standing up Security Force Assistance Brigades (SFAB) in February 2018. The Brigade Medical Team (BMT) is an 11-person, interdisciplinary Army National Guard team. National Guard Soldiers only have one weekend per month and two weeks of annual training per year to develop/maintain cultural competence. The researcher investigated the efficacy of the Cross-Cultural Competence Trainer (3CT) V2 course to develop and maintain cultural competency in BMT personnel. Pre-test results were obtained from three military medical personnel and a post-test immediately after the course. Participants completed a longitudinal test 28-31 days after the post-test. There was a …


Survival Benefit From Immunocheckpoint Inhibitors In Stage Iv Non-Small Cell Lung Cancer Patients With Brain Metastases: A National Cancer Database Propensity-Matched Analysis., Shinkichi Takamori, Takefumi Komiya Md, Emily Powell Dec 2020

Survival Benefit From Immunocheckpoint Inhibitors In Stage Iv Non-Small Cell Lung Cancer Patients With Brain Metastases: A National Cancer Database Propensity-Matched Analysis., Shinkichi Takamori, Takefumi Komiya Md, Emily Powell

PCI Publications and Projects

Immunocheckpoint inhibitors (ICIs) have become a standard pharmacological therapy in non-small cell lung cancer (NSCLC). Because brain metastases (BMs) have historically been listed as exclusion criteria in previous clinical trials involving ICIs in advanced NSCLC, the survival benefit from ICI in NSCLC patients with BMs remains unclear. The National Cancer Database was queried for stage IV NSCLC patients with or without BMs between 2014 and 2015. Overall survival (OS) of stage IV NSCLC patients who received immunotherapy and that of stage IV NSCLC patients who did not receive immunotherapy were compared according to the presence or absence of BMs. Multivariable …


Outcomes Of Chronic Distal Biceps Reconstruction With Tendon Grafting: A Matched Comparison With Primary Repair., Benjamin A. Hendy, Eric M. Padegimas, Thomas Harper, Mark D Lazarus, Joseph A Abboud, Surena Namdari, John Horneff Iii, Md Dec 2020

Outcomes Of Chronic Distal Biceps Reconstruction With Tendon Grafting: A Matched Comparison With Primary Repair., Benjamin A. Hendy, Eric M. Padegimas, Thomas Harper, Mark D Lazarus, Joseph A Abboud, Surena Namdari, John Horneff Iii, Md

Rothman Institute Faculty Papers

Background: The purpose of this analysis was to analyze outcomes of distal biceps reconstruction with soft tissue allograft in the setting of chronic, irreparable distal biceps ruptures. The outcomes of these cases were then compared with a matched cohort of distal biceps ruptures that were able to be repaired primarily.

Methods: Retrospective review of an institutional elbow surgery database was conducted. All cases of distal biceps repairs were identified by Common Procedural Terminology, ICD-9, and ICD-10 codes from January 2009 to March 2018. A direct review of operative reports was then conducted to identify which cases required allograft reconstruction. After …


2020-12-19_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services Dec 2020

2020-12-19_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. It is updated Monday - Saturday.
This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) and rapid virus antigen detection point of …


Quantifying Anticancer Drug Doxorubicin Binding To Dna Using Optical Tweezers, Zachary Ells Dec 2020

Quantifying Anticancer Drug Doxorubicin Binding To Dna Using Optical Tweezers, Zachary Ells

Honors Program Theses and Projects

Doxorubicin is a successful anticancer drug approved for use in the 1970s and is considered to be one of the most effective cancer treatment methods today. Although Doxorubicin has positive survival statistics it has very negative side effects in many cases. Bleeding from the soles of the palms and feet, along with excruciating pain is often exhibited through the administration of this drug. Based on the preliminary findings utilizing optical tweezers we anticipate that this study will provide critical information about the drug binding mechanism. Single molecule biophysics techniques have provided useful insight into the DNA-binding mechanisms of small molecules. …


Spontaneous Tumor Lysis Syndrome In An Adenocarcinoma Of Unknown Origin., Joshua A. Kalter Ms3, Jamie Allen Do, Yuchen Yang Do, Tyler Willing Do, Elizabeth M. Evans Do Dec 2020

Spontaneous Tumor Lysis Syndrome In An Adenocarcinoma Of Unknown Origin., Joshua A. Kalter Ms3, Jamie Allen Do, Yuchen Yang Do, Tyler Willing Do, Elizabeth M. Evans Do

Department of Emergency Medicine

Spontaneous tumor lysis syndrome (STLS) is a rare oncologic emergency caused by massive cancer cell lysis or necrosis without a precipitating factor. Although tumor lysis syndrome (TLS) is most commonly associated with hematologic malignancies, a small number of cases in solid tumor malignancies have been reported. We present a case of spontaneous tumor lysis syndrome in a 77-year-old female with a widely metastatic, poorly differentiated adenocarcinoma of unknown origin. She presented in distributive shock, and laboratory testing at admission revealed acute renal failure, high anion gap metabolic acidosis, hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia. Rasburicase and continuous renal replacement therapy were …


The Effects Of Maternal Delta-9-Tetrahydrocannabinol And Cannabidiol Exposure On Fetal Heart Development In Mice, Gregory Robinson Dec 2020

The Effects Of Maternal Delta-9-Tetrahydrocannabinol And Cannabidiol Exposure On Fetal Heart Development In Mice, Gregory Robinson

Electronic Thesis and Dissertation Repository

Up to 22.6% of pregnant women consume cannabis during pregnancy despite the uncertainty of teratogenicity of the main ingredients in cannabis, delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). This study tested the hypothesis that gestational THC and CBD exposure leads to heart abnormalities. Daily, oral THC exposure induced heart abnormalities in 68% of offspring with three main phenotypes including thickened semilunar valves, ventricular myocardial hypertrophy and hypoplastic coronary arteries in fetuses, and postnatal cardiac dysfunction. Altered gene expression of key cardiogenic regulators, increased proliferation, and reduced epicardial epithelial-to-mesenchymal-transition were demonstrated implicating potential mechanisms responsible for these abnormalities. Also, maternal CBD exposure resulted …


Excerpt From: {Being About To Ascend}, Steven B. Katz Dec 2020

Excerpt From: {Being About To Ascend}, Steven B. Katz

Survive & Thrive: A Journal for Medical Humanities and Narrative as Medicine

This poem constitutes a different take on the theme of this special issue of Survive and Thrive—“Diversity and Community in Narrative Medicine and the Medical Humanities.” An excerpt from a longer poem under development, the poem here is a story of human frailty and limitation at the end of Anthropocene, the end of the age of humans on Earth—perhaps sometime in the not-too-distant future. This poem is thus a “speculative” or “science fiction” story about what happens to a species indigenous and totally adapted to and dependent on the Earth, and which cannot survive anywhere else, must. Facing extinction, the …