Medicine and Health Sciences Commons^™

Effect Of Obturator Nerve Block During Transurethral Resection Of Lateral Bladder Wall Tumors: A Comparison Of Monopolar And Bipolar Tur-Bt Regarding The Presence Of Detrusor Muscle In Tumor Specimens And Recurrence Of Disease, Ehab Noh, Gamal E. Abourjila

Journal of Medicine in Scientific Research

Aim Any unintentional stimulation during electroresection results in adductor contraction and resultant sudden leg movement, which may in turn lead to perforation of bladder or incomplete resection. To avoid this reaction, obturator nerve block (ONB) and bipolar resection is effective to decrease the jerk. Patients and methods A prospective randomized, single-blind study was conducted during 2014–2018. A total of 74 patients were classified into four groups. Group I included 18 patients who received monopolar transurethral resection of bladder tumor (TUR-BT) and group II included 21 patients who received bipolar TUR-BT. Group III included 16 patients who received ONB and monopolar …

Martius Graft Transposition: A Successful Procedure For The Ultimate Repair Of The Anovaginal/Rectovaginal Fistula, Hossam H. Soliman, Mohamed A. Boghdady

Journal of Medicine in Scientific Research

Background Recto/ano-vaginal fistula (RAVF) is one of the worst medical conditions that could lead a lady to suffer in her life. It represents a horrendous experience that might put the lady suffering that ailment not only on the brink of abandoning her social life, but even disrupting her marital life and breaking the integrity of her family. There are various operative methods implemented all over the past decades aiming to cure such medical condition. Of those, interposing a vascularized tissue flap is suggested as an operative solution to guarantee long term successful healing. Of which the most commonly tried is …

Characteristics And Outcomes Of Mitral Valve Repair Surgery: A Single-Center Experience, Ashraf Zahra, Mohamed A. El-Hafez Fouly

Journal of Medicine in Scientific Research

Background The authors performed this retrospective study to report the experience of mitral valve repair (MVR) repair procedures, including the commonly used operative techniques and recorded outcomes. Patients and methods A total of 100 patients (76 males) who underwent MVR were enrolled in this study. Diagnosis was mainly based on detailed history taking along with an echocardiographic assessment. Data on preoperative, intraoperative, and postoperative variables were collected retrospectively from the database and patients' records. Missing data for particular outcomes were removed from the analysis. Results The four observed pathologies of the mitral valve [ischemic (67%), myxomatous (18%), postinfective (11%), and …

Double Valve Repair For Combined Aortic And Mitral Valve Regurgitation: Short-Term Results, Waleed El-Awady

Journal of Medicine in Scientific Research

Introduction Repair of mitral and aortic valve in double valve regurgitation is an attractive alternative to replacement, because of low incidence of valve-related complications. Standardization, reproducibility, and stable results are the three key points that will make any valve repair an established form. This study was undertaken to determine the short-term results of double valve repair for double regurgitation. Patients and methods Twenty-six patients had a double valve repair for aortic and mitral valve regurgitation. The mean age was 37.75 (14–53) years. There were 11 (42.3%) men and 15 (57.7%) women. The mean aortic cross-clamp time was 112 (86–135) min …

Myocardial Longitudinal Strain Reserve As A Marker Of Severity Of Coronary Artery Disease During Dobutamine Stress Echocardiography, Ahmed A. Aziz, Magdy M. Abdelsamie, Rania D. Aboushokka

Journal of Medicine in Scientific Research

Background Timely and prompt detection of coronary artery disease (CAD) is of paramount importance for patient management in daily clinical practice. Several noninvasive stress tests are available for evaluating CAD, of which dobutamine stress echocardiogram (DSE) is widely available for localization and extent of CAD. However, wall-motion analysis during DSE is subjective, so two-dimensional speckle tracking-derived longitudinal strain has been recently presented to allow quantitative assessment of global and regional wall motions. Aim To assess longitudinal strain reserve (LSR) during DSE test in predicting severity of CAD in chronic stable patients. Patients and methods The study included 48 patients with …

Rheumatic Mitral Valve Surgery In Low Ejection Fraction Patients, Ahmed M. Omran, Ahmed Kamel, Emad El Sarawy, Mohamed Roshdy

Journal of Medicine in Scientific Research

Objective Although, in Mitral valve disease, ischemic heart disease and degenerative etiology have the upper hand in developing countries, rheumatic fever still predominates in developing countries including Egypt. Due to delay presentation some patients had very low EF which made the surgery theoretically risky. Our study aims to emphasize the benefit of surgery in this group of patients. Patients and methods 100 consecutive patients with Inclusion criteria: Rheumatic Mitral valve disease +/- Tricuspid valve disease, aging 18 to 75 with Ejection Fraction< 35% Exclusion criteria: Non rheumatic etiology, associated Ischemic Heart Disease, other valvular lesions, redo cases and age less than 18. Results Mean age 49, 57 males, with mean Ejection Fraction 25%, Aortic Cross Clamp time 26 minutes, all …

Causes Of Congenital Corneal Opacities And Their Management In A Tertiary Care Center., Remzi Karadag, Christopher J Rapuano, Kristin M Hammersmith, Parveen K Nagra

Wills Eye Hospital Papers

PURPOSE: To evaluate causes and management of congenital corneal opacities (CCO) diagnosed in a tertiary care eye center and to compare the data with a previous study at the same institution.

METHODS: Computerized medical records in all patients with congenital corneal opacities diagnosed in the Cornea Service at Wills Eye Hospital (Philadelphia, PA) between January 1, 2007, and December 31, 2015, were retrospectively reviewed. Children aged 12 years and younger at the first visit were included in the study. Patients' demographics, ocular diagnosis, laterality, associated ocular abnormalities, other ocular surgery performed prior or subsequent to the first visit, and their …

Cephalic Vein Transposition: An Effective Surgical Option For Dealing With The Cephalic Vein Stenosis, Zia Ur Rehman

Department of Surgery Docs

No abstract provided.

Building Up The Scientific Evidence Base Of Homoeopathy, Anil Khurana

Indian Journal of Research in Homoeopathy

No abstract provided.

Effects Of Individualised Homoeopathic Intervention In Stage I Essential Hypertension: A Single-Blind, Randomised, Placebo-Controlled Trial, Roja Varanasi, Raju Kolli, Yogendra Rai, Dubashi Ramesh, R Kiranmayee, G Chandra Reddy, H Baig, Tejaswini Patole, Priyanka Srivastava

Indian Journal of Research in Homoeopathy

Background: Hypertension (HTN) is a leading risk factor for death and disability and responsible for over 1.6 million deaths in India. Clinical case reports, observational studies and randomised controlled trials show the effects of homoeopathic medicine in HTN. Objectives: The results of this study will add to the evidence of effectiveness of individualised homoeopathic medicine in Stage I HTN. Methods: A single-blind, randomised, placebo-controlled trial was undertaken from October 2013 to March 2018. The primary outcome measure was to evaluate the change in systolic blood pressure (SBP) and diastolic blood pressure (DBP) every month for 3 months. Of 2127 patients …

Proposed Interaction Mechanism Between Medicine And The Diseased Cell In Diluted Homoeopathic Medicine, Bijay Chaudhuri, Biswadeep Chaudhuri

Indian Journal of Research in Homoeopathy

Background: High-diluted homoeopathic medicines practically contain no medicinal molecules. The disease-curing mechanism of homoeopathic medicines has not yet been adequately understood. Acceptable knowledge of this mechanism is essential for further development of homoeopathic science. Objectives: The purpose of this article is to provide a phenomenological model to understand the interaction mechanism between homoeopathic medicines and the diseased cell (DC), which cure diseases with a view to build a conceptual framework that would facilitate subsequent clinical and theoretical investigations. Methods: We have proposed the formation of hydrogen bonded nano and micro clusters (NAM) during the preparation (succession) of homoeopathic medicines. NAM …

Homoeopathic Drug Proving Researches (1996–2018): A Scoping Review, Raj Manchanda, Anil Khurana, Peter Fisher, Bhopal Arya, Pritha Mehra, Subhranil Saha, Munmun Koley, Meenakshi Bhatia

Indian Journal of Research in Homoeopathy

Background: A systematic review on homoeopathic pathogenetic trials (HPTs) from 1945 to 1995 was published in 2007, and the basic question whether the effect produced by homoeopathic drugs in healthy human volunteers is equivalent to placebo or otherwise remained unanswered. There is a need to take up another review of HPTs conducted in the last two decades, to assess the changes in the methodologies adapted and to assess whether the effects produced in apparently healthy volunteers is due to homoeopathic medicines in high dilutions or not. Objective: To seek, collect, review and describe HPTs published during 1996–2018. Materials and Methods: …

A Case Report Of Prurigo Nodularis Responsive To Homoeopathy, Nidhi Mahajan, Deeksha Chaturvedi, Anita Alaria, Girendra Pal

Indian Journal of Research in Homoeopathy

Introduction: Prurigo nodularis (PN) is a chronic, benign neurodermatitis. The exact cause is unknown. In majority, cases of PN do not have a complete resolution of the nodules even with treatment. Case Summary: Here, a diagnosed case of PN of an 18 year old female with a history of 1 year old eczematous lesion is presented. On the basis of the totality of symptoms, homoeopathic medicine Natrium muriaticum was prescribed and gradually the patient showed stable improvement in the domain of signs and symptoms and reached remission by the end of 4 months. There was no recurrence over the next …

Obituary: Dr. Ramanlal Prabhudas Patel, Suhana Azis

Indian Journal of Research in Homoeopathy

No abstract provided.

Chronic Cholelithiasis Treated With Homoeopathic Medicine In 50th Millesimal Potency: A Case Report, Amulya Sahoo, Madhusmita Patnaik, Nilima Khamari, Somyaranjan Sahoo

Indian Journal of Research in Homoeopathy

Introduction: Cholelithiasis or gallstone disease is a very common problem worldwide. The prevalence is more in females than males. Although cholecystectomy is considered the gold standard treatment for symptomatic cholelithiasis, it has its own limitations, risks and post-operative complications. Here, an alternative system of medicine, especially Homoeopathy, plays an important role in treating cholelithiasis. Case Summary: A 32-year-old female patient presented with the symptoms of dull pain in the right hypochondrium, sour eructations and regurgitation of food. The ultrasonography (USG) report confirmed the presence of multiple stones in the gallbladder of varying sizes, from 3 mm to 11 mm. Although …

Does The Oral-Anal Transit Test Correlate With Colonic Manometry Findings In Children With Refractory Constipation?, Jason Dranove, Nathan Fleishman, Saigopala Reddy, Steven Teich

Manuscripts, Articles, Book Chapters and Other Papers

Purpose: The Oral-anal Transit Test (OTT) is a simple method of obtaining information about colonic transit. We aim to assess the correlation of OTT with the neuromuscular integrity of the colon determined by colonic manometry (CM).

Methods: All patients who had OTT followed by CM were evaluated. Less than 6 of 24 markers remaining on OTT was considered normal. CM was performed per previously published guidelines. A normal CM was defined as at least one High Amplitude Propagating Contraction progressing from the most proximal sensor through the sigmoid colon.

Results: A total of 34 patients underwent both OTT and CM …

Deep Learning In Clinical Natural Language Processing: A Methodical Review, Stephen Wu, Kirk Roberts, Surabhi Datta, Jingcheng Du, Zongcheng Ji, Yuqi Si, Sarvesh Soni, Qiong Wang, Qiang Wei, Yang Xiang, Bo Zhao, Hua Xu

Faculty, Staff and Student Publications

OBJECTIVE: This article methodically reviews the literature on deep learning (DL) for natural language processing (NLP) in the clinical domain, providing quantitative analysis to answer 3 research questions concerning methods, scope, and context of current research.

MATERIALS AND METHODS: We searched MEDLINE, EMBASE, Scopus, the Association for Computing Machinery Digital Library, and the Association for Computational Linguistics Anthology for articles using DL-based approaches to NLP problems in electronic health records. After screening 1,737 articles, we collected data on 25 variables across 212 papers.

RESULTS: DL in clinical NLP publications more than doubled each year, through 2018. Recurrent neural networks (60.8%) …

Short-Term Outcome Of Onabotulinumtoxin A Injection For The Treatment Of Refractory Idiopathic Detrusor Overactivity, Amr M. Elsofy, Ayman M. Gabr, Gamal E. A. Abourjila, Khalid F. Elewa

Journal of Medicine in Scientific Research

Introduction There are many theories behind the etiology of refractory idiopathic detrusor overactivity (IDO), but it is generally accepted that it is caused by a combination of myogenic and neurogenic alterations. It is also believed that mucosal sensory systems make a significant contribution to the disorder as well. Intravesical botulinum toxin A (BoNT/A) prevents acetylcholine release at the neuromuscular junction, resulting in temporary chemodenervation and muscle relaxation. The aim of this work was to assessment of outcome of BoNT/A injection for the treatment of refractory IDO. Patients and methods The author included 37 patients who received intravesical BoNT/A for the …

Psychopathic Boldness: Narcissism, Self-Esteem, Or Something In Between?, Joshua D. Miller, Chelsea E. Sleep, Michael L. Crowe, Donald R. Lynam

Department of Psychological Sciences Faculty Publications

Although psychopathy is one of the most studied and well-validated personality disorders, debate remains regarding the necessity and sufficiency of fearless dominance/boldness. This debate revolves around the robust relations boldness shares with adaptive outcomes (e.g., self-esteem) and the limited relations it evinces with psychopathy's other features and outcomes. Although boldness exhibits moderate to large relations with grandiose narcissism, these relations are less frequently examined at the factor level. The present study examines the relations between psychopathic boldness, narcissism, and other adaptive features in a large, MTurk sample (N = 591). While boldness exhibited moderate to large relations with grandiose narcissism, …

Effects Of Inactivated Mycobacterium Bovis Vaccination On Molokai-Origin Wild Pigs Experimentally Infected With Virulent M. Bovis, Pauline Nol, Morgan Wehte, Richard A. Bowen, Suelee Robbe-Austerman, Tyler Thacker, Kristina Lantz, Jack Rhyan, Laurie A. Baeten, Ramón A. Juste, Iker A. Sevilla, Christian Gortazar, Joaquín Vicente

United States Department of Agriculture Wildlife Services: Staff Publications

The wild pig population on Molokai, Hawaii, USA is a possible reservoir for bovine tuberculosis, caused by Mycobacterium bovis, and has been implicated in decades past as the source of disease for the island’s domestic cattle. Heat-inactivated vaccines have been effective for reducing disease prevalence in wild boar in Spain and could prove useful for managing M. bovis in Molokai wild pigs. We designed an experiment to test this vaccine in wild pigs of Molokai genetics. Fifteen 3–4-month-old pigs were orally administered 10⁶–10⁷ colony forming units (cfu) of heat-inactivated M. bovis (Vaccinates; n = 8; 0.2 …

Mmp-7 And Mmp-9 Are Overexpressed In The Synovial Tissue From Severe Temporomandibular Joint Dysfunction, Carla Loreto, Veronica Filetti, Luis Eduardo Almeida, Giusy Rita Maria La Rosa, Rosalia Leonardi, Cristina Grippaudo, Antonino Lo Giudice

School of Dentistry Faculty Research and Publications

Matrix metalloproteinases (MMPs) are tissue-enzymes that play a key role during the remodeling process, such as in inflammatory diseases. MMP-7 and MMP-9 have been shown to be implicated in extracellular matrix homeostasis and in joint disc remodeling. The objective of this study was to determine the relation of MMP-7 and MMP-9 expression with severe temporomandibular joint dysfunction, in particular with anterior disk displacement without reduction (ADDwoR), using an immunohistochemical approach. Therefore, twenty human temporomandibular synovia in the test group and ten in the control group were collected. The results showed there was a statistically significant difference (P<0.001) for morphometric and densitometric analysis of both detected MMPs in control and test groups. In conclusion, MMP-7 and MMP-9 were overexpressed in the synovial tissue of patients with ADDwoR.

Biodegradable Magnesium Bone Implants Coated With A Novel Bioceramic Nanocomposite, Mehdi Razavi, Mohammadhossein Fathi, Omid Savabi, Lobat Tayebi, Daryoosh Vashaee

School of Dentistry Faculty Research and Publications

Magnesium (Mg) alloys are being investigated as a biodegradable metallic biomaterial because of their mechanical property profile, which is similar to the human bone. However, implants based on Mg alloys are corroded quickly in the body before the bone fracture is fully healed. Therefore, we aimed to reduce the corrosion rate of Mg using a double protective layer. We used a magnesium-aluminum-zinc alloy (AZ91) and treated its surface with micro-arc oxidation (MAO) technique to first form an intermediate layer. Next, a bioceramic nanocomposite composed of diopside, bredigite, and fluoridated hydroxyapatite (FHA) was coated on the surface of MAO treated AZ91 …

Mail-Back Envelopes For Retrieval Of Opioids After Pediatric Surgery, Adam C Adler, Ammar N Yamani, Caitlin D Sutton, Danielle M Guffey, Arvind Chandrakantan

Faculty, Staff and Students Publications

BACKGROUND: Opioid overprescription has the potential to lead to harmful medications remaining in homes and to a rise in accidental or deliberate ingestion by children and adolescents. Although methods for opioid disposal are available, many are costly or require greater than minimal effort for the patient. In this study, we used a mail-back return envelope to retrieve unused opioids after ambulatory pediatric surgery.

METHODS: This feasibility study was performed to assess the rate of opioid return by using a mail-back envelope for children ages 0 to 18 prescribed opioids after outpatient surgery. Participants were provided a return envelope as well …

Evaluation Of Acute Myeloid Leukemia Induction Regimens In Elderly Patients With Unfavorable Risk Cytogenetics That Are Candidates For Intensive Remission Therapy, Monica Tadros, Guenther Koehne, Talia Zahra, Moe Shwin, Jessica Unzaga, Nicholas Chow

All Publications

No abstract provided.

Histogenesis And Histochemical Features Of Gastric Glands Of Pre-Hatch And Post-Hatch Broiler Chicken, Anietie Francis Udoumoh, Innocent Chima Nwaogu, Udensi Maduabuchi Igwebuike, Ikechukwu Reginald Obidike

The Thai Journal of Veterinary Medicine

The objective of this study was to evaluate the morphological development of the stomach of broiler chicken using histological and histo-chemical techniques. Thirty fertile eggs and 50 chicks of broiler chicken were used for the study. The results showed that at embryonic day (ED) 14, the simple tubular glands of the proventriculus were poorly defined while the framework of the compound tubular glands of the proventriculus were fully established. The secretory tubules of the compound tubular glands were lined by simple cuboidal cells at embryonic days 14, 17 and 19. However, at post-hatch days 1, 3, 7, 14, and 21, …

Responses Of Swine Associated Methicillin-Resistant Staphylococcus Aureus Against Human Lung Carcinoma Epithelial Cell Line A549, Min Tao Wan, Chin Cheng Chou

The Thai Journal of Veterinary Medicine

Staphylococcus aureus (S. aureus) has been shown to adhere, invade, and induce the death of various host cells. The prominent lineage of livestock-associated methicillin-resistant S. aureus (LA-MRSA) in Asia is the sequence type (ST) 9 that has emerged as a potential zoonotic pathogen. However, the virulence of LA-MRSA ST9 remains not clear. In this study, sixteen representative Taiwan LA-MRSA isolates were selected for adherence, invasion, and cytotoxicity studies against the human lung carcinoma epithelial cell line A549. The isolates showed 100% of cytotoxicity, 35.2% - 61% of adhesion, and 18% - 52.5% of invasion against A549 cells. Different adherent abilities …

Comparison Of Plasma-Lyte A And Trometamol-Balanced Priming Solutions For Cardiopulmonary Bypass In A Swine Model: A Pilot Study, Wen-Ting Ting, Lee-Mei Ponge, Heng-Wen Chou, Chih-Hsien Wang, Yih-Sharng Chen, Jih-Jong Lee

The Thai Journal of Veterinary Medicine

Currently, the optimal priming solution for cardiopulmonary bypass (CPB) remains debatable. However, plasmalyte A solution (PLAS) has been widely used in the United States and is considered to be the standard priming solution worldwide. Therefore, we designed a trometamol-balanced solution (Resculyte® solution, RS) to evaluate the safety and feasibility for its use as a priming solution during CPB compared to PLAS. In total, 8 white pigs that underwent CPB were assigned 1:1 to PLAS and RS groups. Hemodynamic parameters were recorded using an Abbott i-STAT analyzer with CG4+ (for pH, pressure of carbon dioxide, pressure of oxygen , total carbon …

Involucrin, Cytokeratin 10 And Ki67 Expression In A Threedimensional Cultured Canine Keratinocyte Cell Line In Comparison To Canine Skin And Cutaneous Squamous Cell Carcinoma And A Pilot Study On Custom-Designed Sirna-Inv Transfection, Nongnut Assawawongkasem, Somporn Techangamsuwan, Prapruddee Piyaviriyakul, Pranom Puchadapirom, Achariya Sailasuta

The Thai Journal of Veterinary Medicine

Involucrin (INV) is a well-known early stage marker of terminal keratinocyte differentiation in humans. Besides its importance in human cancer, it has been predicted to be a prognostic marker in canine skin cancer. However, there is very little information available on canine INV. Therefore, for the first time, a three-dimensional (3D) cultured canine keratinocyte cell line was evaluated for the expression level of INV and two other cancer prognostic parameters, cytokeratin 10 (CK10) and Ki67, compared to that in canine normal skin (CN) and cutaneous squamous cell carcinoma (CSCC) cells. The INV protein and transcript expression levels were significantly (p < 0.005) higher in canine CN compared to in CSCC, whereas Ki67 expression levels were significantly (p < 0.05) lower in CN than in CSCC. The culture of a commercial canine keratinocyte cell line (CPEK; CELLnTEC Advanced Cell Systems, Switzerland) to produce the 3D epidermal skin was successfully achieved under an air-liquid interface for 14 d of culture. There was no statistical difference in the INV and CK10 expression levels between the 3D-cultured CPEK cells and CN. A custom designed INV siRNA transfected at 300 pmol showed the high efficacy of INV knockdown with minimum cytotoxicity to cultured CPEK cells, significantly reducing the INV mRNA expression level after 5 h transfection for up to 48 h. This is the first report on the custom design of siRNA transfection in monolayer cultured CPEK cells for INV gene knockdown in dogs and it could be useful for future studies on the carcinogenesis of CSCC.

The Effects Of Alkaline Water And Rainwater On The Production And Health Performance Of Commercial Broilers Under Tropical Conditions, Eric Lim Teik Chung, Nazri Nayan, Mamat Hamidi Kamalludin, Mohamed M. Alghirani, Faez Firdaus Abdullah Jesse, Nafeesa Abu Kassim, Aqila Azizi, Mohd Farhan Hanif Reduan, Teck Chwen Loh

The Thai Journal of Veterinary Medicine

Water consumption of a broiler is affected by temperature and the absence or presence of some minerals which could affect its production. Therefore, this study aimed to determine the impact of giving alkaline water and rainwater on the growth performance, carcass characteristics, meat quality and white blood cell changes of broilers under tropical condition. A total of 108 broiler birds (Cobb 500) were randomly divided into three treatment groups with six replicates consisting of six birds per replicate. Treatment 1 (control), 2 and 3 were provided with available tap water (pH 7.17), sodium bicarbonate alkaline water (pH 8.05) and chlorinated …

Association Of Snps In The Coding Regions Of Cd4 Gene With Mastitis Susceptibility And Production Traits In Dairy Cattle, Saqib Zeb, Nawab Ali, Sadaf Niaz, Arsalan Rasheed, Irfan Khattak, Naimat Ullah Khan, Yachun Wang, Tahir Usman

The Thai Journal of Veterinary Medicine

CD4 gene is reported to have significant role in various inflammatory conditions including mastitis. Therefore, the current study was designed to screen out single nucleotide polymorphisms (SNPs) in the bovine CD4 gene and to evaluate its effects on mastitis indicator and production traits. Total 201 milk and blood samples were collected from dairy cattle maintained at government dairy farms of Khyber Pakhtunkhwa, Pakistan. Milk samples were used for DHI test (milk composition and somatic cell count) and the blood for DNA extraction. SNPs were initially detected in the pool DNA samples followed by screening in the whole cohort. The association …