Medicine and Health Sciences Commons^™

Host Modulation And The Inflammatory Response, Carleigh Fraley, Jennifer Knox-Rodriguez, Diana V. Macri

Publications and Research

Host modulation therapy may be effective in controlling the immune response responsible for periodontal diseases.

Mobilization Of The Substance Use Disorder Recovery Community In The Time Of Coronavirus, Austin Mcneill Brown

Population Health Research Brief Series

This issue brief explains the recovery community's resilient response to the social distancing mandates from COVID-19 and notes recommendations for policymakers. This brief also includes a broad list of recovery resources.

Diabetes Debunked: What You Need To Know, Maggie Hutson

Honors Program: Senior Projects (Public)

The goal of this Honors creative project is to encourage health literacy in populations who are curious about Type 2 Diabetes or have Type 2 Diabetes. From personal experience, I have seen noncompliance in diabetics and wondered why since it is a serious, progressive disease. After researching, I found that some diabetics do not understand the scope of their disease, especially since many of the dangerous complications that arise from Type 2 Diabetes do not present until later in the disease when it is too late. For my senior project, I decided to write an educational paper as a supplement …

Communication, Leadership And Organizational Support Facilitates Successful Transition Into Practice For Nurse Practitioners In The Emergency Department, Cheryl Anne Soco

College of Science and Health Theses and Dissertations

Background and purpose: Post-graduate programs, specialized academic programs, and national health organizations like the Institute of Medicine (IOM) have identified and begun addressing the gap in knowledge, skills and factors for successful transition into practice. The purpose of this study is to examine the relationships and differences among the personal and community resources which promote successful transition for Nurse Practitioners (NP) that practice in the Emergency Department (ED) and the skills or procedures they find difficult to perform independently.

Methods: A descriptive, correlational-comparative study design was conducted using an online survey administered to a convenience sample of NPs with …

Improving Care For Homeless Young Adults: A Shelter Client And Health Service Provider Perspective, Kenya K. Hemingway

College of Science and Health Theses and Dissertations

The purpose of this study was to determine if the healthcare needs of homeless young adults from the client, shelter staff, and shelter healthcare provider’s perspectives. Data was collected via focus group with homeless unaccompanied young adults (n=4), and an online survey with shelter staff and healthcare staff (n=8) of The Night Ministry (TNM) and Ignite Promise. The focus group was recorded, transcribed, and coded for themes. Inductive analysis revealed themes focused on improving the quality of services provided. Based on the findings, recommendations include assessing the needs of homeless unaccompanied young adults from their perspective utilizing larger sample sizes, …

Pilot Study: Educational Tool Reduces Parental Stress At Home Post Pediatric Cardiac Surgery, Rachel Barsella

College of Science and Health Theses and Dissertations

Congenital heart disease is a prevalent health issue in patients around the world. Approximately 8 in 1,000 live births are complicated by congenital heart disease (Ndile & Kohi, 2011). Increased levels of stress and anxiety have been reported by parents of children with congenital heart disease throughout the process of cardiac surgery, hospitalization, and especially discharge home (Brown & Smith, 2018). This pilot research study utilized pre-intervention and post-intervention survey methodology to examine the impact of an educational tool on parental stress while caring for their child at home post cardiac surgery. The educational tool created by the researcher was …

Community Level Perspectives On Informal Alcohol: Understanding The Role Of Traditional Brewers In Dowa District, Malawi, Brian Allen, Jeff Glenn Dr.

Undergraduate Honors Theses

Alcohol consumption and consequential public health problems have recently increased in Sub-Saharan Africa and alcohol has been identified as the leading contributor to the burden of disease in the region. While Malawi has a relatively low overall alcohol consumption rate, the majority of the alcohol produced and consumed in the country is informal or unrecorded alcohol which present significant monitoring and regulatory challenges, in addition to greater health risks. This article explores the community level perspectives from traditional brewers of alcohol, and provides a comprehensive look into their experiences, perspectives, and the roles they play in their communities. In addition …

Pediatric Resident Knowledge, Experience, Comfort, And Perceived Competency In Providing Sibling Psychosocial Support., David Buchbinder, Sonam Sidhu, Melissa A. Alderfer, Anne Lown, Russ C. Kolarik, Tommy Wang

Department of Pediatrics Faculty Papers

This article is the author’s final published version in International Journal of Medical Education, Volume 11, March 2020, Pages 73-75.

The published version is available at https://doi.org/10.5116/ijme.5e63.6a46. Copyright © Buchbinder et al.

Religious Beliefs, Social Pressure, And Stigma: Rural Women’S Perceptions And Beliefs About Vasectomy In Pwani, Tanzania, Eunice Pallangyo, Agnes Msoka, Sharon Brownie, Eleanor Holroyd

School of Nursing & Midwifery, East Africa

Despite being a reliable and cost effective family planning method, vasectomy remains underutilized in many low resource settings such as East Africa. We explored rural women’s perceptions and beliefs regarding barriers to vasectomy use in the low resource setting of Pwani, Tanzania. The qualitative study used in-depth semi-structured interviews to obtain data. Purposive sampling was used to recruit 20 married/cohabiting women with two or more children. Thematic analysis guided the data analysis, with qualitative data reporting informed by COREQ guidelines. Most participants were Muslim and had between two and six children. Most had completed primary-level education and were engaged in …

Osteoblastoma In The Occipital Bone: A Case Report Of A Rare Tumor In The Calvarium, Lukas M. Trunz, Scott H. Faro, Richard J. Gorniak

Department of Radiology Faculty Papers

Osteoblastomas infrequently occur in the calvarium, displaying a preference for temporal and frontal bones when it does. We present an unusual case of a large, expansile osteoblastoma in the occipital bone of a 23-year-old man who presented with a nontender lump at the back of his head. Initial computed tomography scan showed a large occipital bone mass, and after additional imaging, a gross total resection was performed. Histopathological examination revealed an osteoblastoma. Although these tumors are benign, overlapping imaging characteristics of lesions affecting the calvarium often present a diagnostic dilemma. This case emphasizes the importance of imaging in the management …

An Examination Of Certified Nurse-Midwives’ Attitudes And Beliefs Surrounding Breastsleeping: Implications For Advanced Nursing Practice And Education, Lucy Wiesemann

College of Science and Health Theses and Dissertations

Introduction: Breastsleeping, defined as co-sleeping while breastfeeding, is a practice commonly employed in breastfeeding families. However, literature examining this concept, its prevalence, and related education for safe breastsleeping is scant. Providers' attitudes surrounding breastsleeping play an essential role in practice and outcomes when caring for breastfeeding patients and families. The purpose of the study was to examine and describe Certified Nurse-Midwives' attitudes and beliefs surrounding breastsleeping.

Methods: An adapted 18-item Nurse Attitudes and Beliefs Questionnaire-Revised (NABQ-R) online-survey that measured breastsleeping attitudes and beliefs of Certified Nurse-Midwives was administered via an online survey platform (Qualtrics). The quantitative analysis utilized SPSS 25 …

Improving Care For Homeless Young Adults: A Shelter Client And Health Service Provider Perspective, Kenya K. Hemingway

College of Science and Health Theses and Dissertations

The purpose of this study was to determine if the healthcare needs of homeless young adults from the client, shelter staff, and shelter healthcare provider’s perspectives. Data was collected via focus group with homeless unaccompanied young adults (n=4), and an online survey with shelter staff and healthcare staff (n=8) of The Night Ministry (TNM) and Ignite Promise. The focus group was recorded, transcribed, and coded for themes. Inductive analysis revealed themes focused on improving the quality of services provided. Based on the findings, recommendations include assessing the needs of homeless unaccompanied young adults from their perspective utilizing larger sample sizes, …

Follow Up Care For Heart Failure Patients And Association With Hospital Readmission, Supraja Thunuguntla, Michael Machiorlatti, Sonya Rivera, Juan Cortinas Galvan, Jose Campo Maldonado

School of Medicine Publications

Background:

The CDC reports 6.5 million adults in the US have Heart failure (HF) with yearly costs topping 30 billion. HF patients admitted to Valley Baptist (VB) are readmitted 26% of the time, which is close to the national average of 23% [1]. Standard of care for HF patients is remote nursing care for 30 days from discharge. A hospitalization for any reason within 30 days is considered a “readmission”. On October 1, 2019 at VB remote nursing care changed from weekly house visits to weekly phone calls. The aim of the study is to evaluate the effectiveness of this …

The Genetic Architecture Of The Human Cerebral Cortex, Katrina L. Grasby, Neda Jahanshad, Jodie N. Painter, Lucia Colodro-Conde, Janita Bralten, Derrek P. Hibar, Penelope A. Lind, Fabrizio Pizzagalli, Marcio A. Almeida, Joanne E. Curran, John Blangero

School of Medicine Publications

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area …

Enigma And Global Neuroscience: A Decade Of Large-Scale Studies Of The Brain In Health And Disease Across More Than 40 Countries, Paul M. Thompson, Neda Jahanshad, Christopher R. Ching, Lauren E. Salminen, Sophia I. Thomopoulos, Joanna Bright, Bernhard T. Baune, Sara Bertolín, Janita Bralten, Anderson M. Winkler

School of Medicine Publications

This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide data and expertise to answer fundamental questions in neuroscience, psychiatry, neurology, and genetics. Most ENIGMA WGs focus on specific psychiatric and neurological conditions, other WGs study normal variation due to sex and gender differences, or development …

2020-03-19 A Message From Chancellor Roth, Paul B. Roth

HSC Messages from the Chancellor

No abstract provided.

A Message To Our Students About Move-Out, March 19, 2020, University Of Northern Iowa

UNI Response to COVID-19

A memo to students living in the dormitories concerning the move-out of those who can move to their family homes, detailing the days and times students can do so.

2020-03-19_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 2 p.m., with yesterday’s COVID-19 positive results included as of 10 a.m.

The website contained the tables Confirmed COVID-19 Cases by County, Tests, Percentage of Cases by Sex, and Percentage of Cases by Age.

Functional Blockade Of E-Selectin In Tumor-Associated Vessels Enhances Anti-Tumor Effect Of Doxorubicin In Breast Cancer, Yoshihiro Morita, Macall Leslie, Hiroyasu Kameyama, Ganesh L R Lokesh, Norihisa Ichimura, Rachel Davis, Natalie Hills, Nafis Hasan, Roy Zhang, Yuji Kondo, David G Gorenstein, David E Volk, Inna Chervoneva, Hallgeir Rui, Takemi Tanaka

Department of Pharmacology and Experimental Therapeutics Faculty Papers

Chemotherapy is a mainstay of treatment for solid tumors. However, little is known about how therapy-induced immune cell infiltration may affect therapy response. We found substantial CD45+ immune cell density adjacent to E-selectin expressing inflamed vessels in doxorubicin (DOX)-treated residual human breast tumors. While CD45 level was significantly elevated in DOX-treated wildtype mice, it remained unchanged in DOX-treated tumors from E-selectin null mice. Similarly, intravenous administration of anti-E-selectin aptamer (ESTA) resulted in a significant reduction in CD45+ immune cell density in DOX-treated residual tumors, which coincided with a delay in tumor growth and lung metastasis in MMTV-pyMT mice. Additionally, both …

The Attitude Of Medical Practices Toward Lgbt Older Adults Before And After Intervention, Lynn M. Wilson Do, Mackenzi B. Kim Md, Nyann Biery Ms, Brenda Frutos Mph, Ches

Department of Family Medicine

No abstract provided.

Understanding The Dimensions Of Medical Crowdfunding: A Visual Analytics Approach, Jie Ren, Viju Raghupathi, Wullianallur Raghupathi

Publications and Research

Background: Medical crowdfunding has emerged as a growing field for fundraising opportunities. Some environmental trends have driven the emergence of campaigns to raise funds for medical care. These trends include lack of medical insurance, economic backlash following the 2008 financial collapse, and shortcomings of health care regulations.

Objective: Research regarding crowdfunding campaign use, reasons, and effects on the provision of medical care and individual relationships in health systems is limited. This study aimed to explore the nature and dimensions of the phenomenon of medical crowdfunding using a visual analytics approach and data crawled from the GoFundMe crowdfunding platform in 2019. …

Development And Psychometrics Of The English Version Of The Itch Cognitions Questionnaire, Carolyn J. Heckman, Christina Schut, Mary Riley, Anke Ehlers, Rodrigo Valdes-Rodriguez, Jörg Kupfer, Uwe Gieler, Jerod L. Stapleton

Health, Behavior & Society Faculty Publications

BACKGROUND: The aim of this study was to validate the English version of the Itch Cognition Questionnaire in a sample of patients with chronic itch due to psoriasis or atopic dermatitis. An English-language version of an instrument assessing itch-related cognitions is needed since cognitions can contribute to a worsening of itch, and chronic itch is prevalent in English-speaking counties and internationally.

METHODS: The German Itch Cognitions Questionnaire was translated into English, and cognitive interviewing was conducted to finalize item wording. Internal and test-retest reliability, item discrimination, responsiveness to change, and construct, convergent, and discriminant validity were assessed in a national …

Neutrophil Infiltration Into The Cervical Compartment Is Suppressed By Hiv Infection, Madeline Maschka

Honors Program: Senior Projects (Public)

Human Papillomavirus (HPV), is a small circular dsDNA virus with at least 200 different genotypes; each genotype is identified by at least 10% difference at the DNA level in the L1 capsid gene. Each HPV genotype affects the body in different tissues, either mucosal or cutaneous. Mucosal HPVs type 16 and 18 are known as high-risk strains, since HPV infection is the most common cause of cervical cancer and plays a central role in formation of precancerous lesions. Human immunodeficiency virus (HIV) damages the body’s immune system by targeting CD4+ T cells. Once CD4+ T cells are infected, the body …

Covid-19: Playing The Long Game For Your Mental Health, Mary Kate Schutt

Population Health Research Brief Series

This issue brief provides a new lens to view the pandemic of COVID-19 and offers simple, practical, and action-oriented ways to mange your mental health for the long term during this time of uncertainty.

As Schools Close Due To The Coronavirus, Mental Health Care For Children Must Be Protected, Xiaoyan Zhang

Population Health Research Brief Series

This data slice highlights the expansive nation-wide school closings due to COVID-19 and encourages providers and government bodies to support the mental health needs of students across the country.

A Comparison Of Verbal Feedback And Video Feedback To Improve Dance Skills, Shreeya Sudhir Deshmukh

USF Tampa Graduate Theses and Dissertations

Research has shown that video feedback and verbal feedback can improve a variety of skills related to several sports. The purpose of this study was to compare the effectiveness of these two forms of feedback for improving dance skills. In this study, the dance skills of three participants were assessed. Verbal feedback and video feedback were implemented using a multiple baseline across participants with an embedded alternating treatments design to allow for a direct comparison of the interventions. The results indicated that verbal feedback was more effective for one participant and video feedback was more effective for one participant. More …

Functional Blockade Of E-Selectin In Tumor-Associated Vessels Enhances Anti-Tumor Effect Of Doxorubicin In Breast Cancer, Yoshihiro Morita, Macall Leslie, Hiroyasu Kameyama, Ganesh L. Lokesh, Norihisa Ichimura, Rachel Davis, Natalie Hills, Nafis Hasan, Roy Zhang, Yuji Kondo, David G. Gorenstein, David E. Volk, Inna Chervoneva, Hallgeir Rui, Takemi Tanaka

Faculty Publications

Chemotherapy is a mainstay of treatment for solid tumors. However, little is known about how therapy-induced immune cell infiltration may affect therapy response. We found substantial CD45 immune cell density adjacent to E-selectin expressing inflamed vessels in doxorubicin (DOX)-treated residual human breast tumors. While CD45 level was significantly elevated in DOX-treated wildtype mice, it remained unchanged in DOX-treated tumors from E-selectin null mice. Similarly, intravenous administration of anti-E-selectin aptamer (ESTA) resulted in a significant reduction in CD45 immune cell density in DOX-treated residual tumors, which coincided with a delay in tumor growth and lung metastasis in MMTV-pyMT mice. Additionally, both …

Male Luts – Introduction And Overview, Thenappan Chandrasekar, Md

Department of Family & Community Medicine Presentations and Grand Rounds

Outline & Goals

• Background – What are “LUTS”?

• Anatomy

• Pathophysiology

• Storage – bladder filling symptoms
• Voiding – urine flow symptoms
• Post-micturition

• Major etiologies and management

• BPH / BOO
• OAB
• Nocturia

• Related to Prostate Cancer?

Mob Family Proteins: Regulatory Partners In Hippo And Hippo-Like Intracellular Signaling Pathways, Juan Carlos Duhart, Laurel A. Raftery

Life Sciences Faculty Research

Studies in yeast first delineated the function of Mob proteins in kinase pathways that regulate cell division and shape; in multicellular eukaryotes Mobs regulate tissue growth and morphogenesis. In animals, Mobs are adaptors in Hippo signaling, an intracellular signal-transduction pathway that restricts growth, impacting the development and homeostasis of animal organs. Central to Hippo signaling are the Nuclear Dbf2-Related (NDR) kinases, Warts and LATS1 and LATS2, in flies and mammals, respectively. A second Hippo-like signaling pathway has been uncovered in animals, which regulates cell and tissue morphogenesis. Central to this emergent pathway are the NDR kinases, Tricornered, STK38, and STK38L. …

How To Stop Touching Your Face To Minimize Spread Of Coronavirus And Other Germs, Stephen D. Benning, Brian Labus, Kimberly Barchard

Psychology Faculty Research

Public health officials consistently promote hand-washing as a way for people to protect themselves from the COVID-19 coronavirus. However, this virus can live on metal and plastic for days, so simply adjusting your eyeglasses with unwashed hands may be enough to infect yourself. Thus, the Centers for Disease Control and Prevention and the World Health Organization have been telling people to stop touching their faces.