Is Photoacoustic Imaging Clinically Safe: Evaluation Of Possible Thermal Damage Due To Laser-Tissue Interaction, Hailey Olds, Darius Mehregan, Karl Kratiewicz, Rayyan Manwar, Qiuyun Xu, Shirya Reddy, Sadreddin Mahmoodkayayeh, Kamran Avanaki

Medical Student Research Symposium

Photoacoustic imaging is a breakthrough imaging modality that combines the spatial resolution of ultrasound imaging with the contrast of optical imaging. This imaging technique is being pushed towards clinical acceptance for many applications, such as noninvasive diagnosis and management of a multitude of neoplastic lesions. However, a rigorous evaluation of the tissue thermal response to the laser illumination is required prior to the clinical translation. In this study, we assessed the temperature rise profile and microstructural damage of the skin due to the laser-tissue interaction using in-vivo mouse models. We compared the effect of two different laser frequencies (10 Hz …

New Guidance For Out-Of-State Travelers, March 24, 2020, University Of Northern Iowa

UNI Response to COVID-19

A memo stating that any non-essential classified UNI employee who traveled out to state are to self-isolate for 14 days upon their return.

First-In-Human Visone Heart Failure Study: Asymptomatic Diaphragmatic Stimulation For Chronic Heart Failure With Reduced Ejection Fraction: Case Report, Ana Jorbenadze, Nikoloz Shaburishvili, Michael Mirro Md, Facc, Fhrs, Faha, Michel Zuber, Paul Erne, Tamaz Shaburishvili

Parkview Heart Institute

Background

Asymptomatic Diaphragmatic Stimulation (ADS) is a novel device-based HF therapy under investigation. ADS gaited with the cardiac cycle transiently modulates intrathoracic pressure, thereby enhancing pre- and afterload, and stroke volume. It is hypothesized that ADS improves cardiac function and exercise tolerance in HFrEF patients.

Methods

HFrEF patients (15) underwent laparoscopic implantation of the VisONE ADS system (NCT03484780). Post-implant stimulation levels imperceptible to the patient are determined. At discharge, ADS therapy is turned on. Measures of cardiac function, HF status, QoL and adverse events are assessed every 3 months for 12 months.

Results

Results are presented from an initial patient …

Helping Students With Technology, March 24, 2020, University Of Northern Iowa

UNI Response to COVID-19

A memo to UNI faculty on how to help students deal with technology and limited bandwidth.

2020-03-24_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 2 p.m., with COVID-19 results included as of 10 a.m.

Note on cumulative counts: This report is provisional and subject to change. As public health investigations of individual cases continue, there will be corrections to the status and details of referred cases that result in changes to this report.
Note on the deaths: Deaths must be reported by health care providers, medical examiners/coroners, and recorded by local health …

Allogeneic Autophagosome-Enriched Composition For The Treatment Of Disease, Traci Hilton, Sandra Aung, Rieneke Van De Ven, Christopher Paustian, Tarsem Moudgil, Christopher Dubay, Christopher Twitty, Hong-Ming Hu, Bernard A Fox

Technology Transfer - Patents

A method is presented for screening cells that produce allogeneic autophagosome enriched compositions able to induce expression of a selective marker on a subpopulation of peripheral blood mononuclear cells, the method comprising contacting a cell with a proteasome inhibitor, contacting the cell with a lysosome inhibitor, harvesting the resulting autophagosomes, determining a molecular signature of the harvested autophagosomes, and selecting cells that divert one or more Toll-like receptor agonist and/or one or more molecular chaperones to the harvested autophagosomes. By screening for cells that divert one or more Toll-like receptor agonist and/or one or more molecular chaperones to the harvested …

Allogeneic Autophagosome-Enriched Composition For The Treatment Of Disease, Traci Hilton, Sandra Aung, Rieneke Van De Ven, Christopher Paustian, Tarsem Moudgil, Christopher Dubay, Christopher Twitty, Hong-Ming Hu, Bernard A Fox

Technology Transfer - Patents

A method is presented for screening cells that produce allogeneic autophagosome enriched compositions able to induce expression of a selective marker on a subpopulation of peripheral blood mononuclear cells, the method comprising contacting a cell with a proteasome inhibitor, contacting the cell with a lysosome inhibitor, harvesting the resulting autophagosomes, determining a molecular signature of the harvested autophagosomes, and selecting cells that divert one or more Toll-like receptor agonist and/or one or more molecular chaperones to the harvested autophagosomes. By screening for cells that divert one or more Toll-like receptor agonist and/or one or more molecular chaperones to the harvested …

Student Resources To Assist You, March 24, 2020, University Of Northern Iowa

UNI Response to COVID-19

A memo to students from the Vice President of Student Affairs about the services still available on campus and virtually.

Research Activity At Uni During Coronavirus Pandemic, March 24, 2020, University Of Northern Iowa

UNI Response to COVID-19

A memo from the Associate Vice President of Research & Innovation addressing how research activity, including laboratory work, should be conducted during the COVID-19 outbreak.

Comparison Of Echocardiographic Outcomes Following Transcatheter Aortic Valve Replacement With Edwards S3 23 Mm Versus Medtronic Evolut 26 Mm Valves, Michael Ring, Ruyun Jin, Rollie Parrish, Brydan Curtis, Matthew Forrester, Branden Reynolds, Sameer Gafoor

Articles, Abstracts, and Reports

Background

Patients with small aortic valve annulus (SAVA) undergoing TAVR are prone to higher post TAVR trans-valve gradients. In many such patients, the choice of TAVR valve commonly involves choosing between the Edwards S3 23 mm (ES23) versus the Medtronic Evolut 26 mm (ME26). The supraannular design of the Evolut has been touted as providing superior hemodynamics in SAVA. We sought to compare performance of these two valves in SAVA, particularly in regard to occurrence of elevated trans-valve gradients.

Methods

We queried the Providence St Joseph Health STS/ACC TVT Registry database for patients undergoing TAVR for SAVA with either the …

Struggling With Long-Time Low Uptake Of Modern Contraceptives In Pakistan, Nasim Zahid Shah, Tazeen S. Ali, Imtiaz Jehan, Xaher Gul

Woman and Child Health

Background: Efforts to expand access to reproductive health care in Pakistan date as far back as the early 1950s. Despite such efforts, the fertility rate has declined at a slower pace compared to that in neighbouring countries.
Aims: To explore the underlying reasons and challenges for long-time low contraceptive use among female clients and key service providers of community-based family planning programmes in Pakistan.
Methods: A qualitative study was carried out with a total of 10 focus group discussions and 7 in-depth interviews with female clients and key service providers. The data were analysed using qualitative content analysis.
Results: The …

Method And System For Diterpene Production Platforms In Yeast, Joseph Chappell, Xun Zhuang, Shuiqin Wu

Pharmaceutical Sciences Faculty Patents

A method is provided for modifying yeast to express mutant avian farnesyl disphospate synthase and the resulting modified yeast. The yeast advantageously includes additional mutants including but not limited to having ergosterol dependent growth and being erg-. The modified yeast are beneficial for the production of various terpenes including diterpenes.

Differences In Outcomes Of St-Segment Elevation Myocardial Infarction In African American Women Versus Women From Other Races: A United States National Study., Tasleem Katchi, Sanja Virani, Shaun Smithson, Bryan Curry

Cardiology

No abstract provided.

Using Medical Claims Database To Develop A Population Disease Progression Model For Leuprorelin-Treated Subjects With Hormone-Sensitive Prostate Cancer, Yixuan Zou, Fei Tang, Jeffery C. Talbert, Chee M. Ng

Pharmacy Practice and Science Faculty Publications

Androgen deprivation therapy (ADT) is a widely used treatment for patients with hormone-sensitive prostate cancer (PCa). However, duration of treatment response varies, and most patients eventually experience disease progression despite treatment. Leuprorelin is a luteinizing hormone-releasing hormone (LHRH) agonist, a commonly used form of ADT. Prostate-specific antigen (PSA) is a biomarker for monitoring disease progression and predicting treatment response and survival in PCa. However, time-dependent profile of tumor regression and growth in patients with hormone-sensitive PCa on ADT has never been fully characterized. In this analysis, nationwide medical claims database provided by Humana from 2007 to 2011 was used to …

The Effects Of Exercise On Mental Health, Xavier A. Pinex

Honors Thesis

Exercise is an extremely important aspect towards positive mental health. Multiple studies have been done previously that show one benefit or another that exercise has towards mental health, but previously there had been no attempt to summarize the findings of these studies. The benefits that exercise has to an individual’s mental health are numerous, but despite this exercise is an underutilized tool in the quest for better mental health. There are many variables that affect the benefits of exercise to an individual’s mental health and it is important to understand all these variables to understand how to properly exercise to …

Biliary Dyskinesia In Children And Adolescents: A Mini Review., David Simon, Craig A. Friesen, Jennifer Verrill Schurman, Jennifer Colombo

Manuscripts, Articles, Book Chapters and Other Papers

Introduction: While functional gallbladder disorder is a well-recognized and defined condition in adults, its pediatric analog, biliary dyskinesia, lacks uniformity in diagnosis. Yet, biliary dyskinesia is among the most common conditions resulting in cholecystectomy in youth and its frequency continues to rise. The primary aims of the current review were assess the efficacy of cholecystectomy in children diagnosed with biliary dyskinesia and the utility of cholescintigraphy in predicting outcomes.

Results: All previous studies assessing outcomes in youth with biliary dyskinesia have been retrospective and therefore of low quality. There is a lack of uniformity in patient selection. Short term follow-up …

Challenges In Conducting Online Survey Research Of The Relationship Between Unit-Level Perceived Team Trustworthiness And Clinical And Operational Outcomes, Nancy Ballard, Lynn Varagona, Rob Stilson, Kimberly Knotts, Joan Sacerio

Faculty Articles

When conducting online survey research, obtaining an adequate response rate in order to have meaningful, reliable data can be challenging. In our study examining hospital unit-level data, a 40% response rate was needed to adequately reflect the degree to which unit staff perceived one another as trustworthy. In addition, approximately 150 units were needed to analyze the relationship between perceived trustworthiness and selected operational and quality outcomes.

In spite of following best practices for survey research (e.g., careful communication planning, short survey length) in a multi-hospital study system, most of the units’ response rates were inadequate to include the units …

2020-03-24 A Message From Chancellor Roth, Paul B. Roth

HSC Messages from the Chancellor

No abstract provided.

Physician Behaviors, Nursing, And Other Obstacles In End-Of-Life Care: Additional Critical Care Nurse Perceptions, Elizabeth Elouise Willmore

Theses and Dissertations

Background: Critical Care Nurses (CCNs) frequently provide end of life (EOL) care in intensive care units (ICUs). Barriers to EOL care in ICUs exist and have been previously published, but qualitative reports from CCNs themselves remain scarce. Qualitative data exploring barriers faced during ICU EOL care may increase awareness of obstacles and help remove them. Objective: Excluding family experiences, what are the major themes recounted by CCNs when asked to share common obstacles experienced in providing ICU EOL care? Methods: Members of the American Association of Critical-Care Nurses were randomly surveyed and responses to a single qualitative question were used. …

Nf-Κb Inhibitors Attenuate Mcao Induced Neurodegeneration And Oxidative Stress—A Reprofiling Approach, Awais Ali, Fawad Ali Shah, Alam Zeb, Imran Malik, Arooj Mohsin Alvi, Lina Tariq Alkury, Sajid Rashid, Ishtiaq Hussain, Najeeb Ullah, Arif Ullah Khan, Phil Ok Koh, Shupeng Li

All Works

© Copyright © 2020 Ali, Shah, Zeb, Malik, Alvi, Alkury, Rashid, Hussain, Ullah, Ullah Khan, Koh and Li. Stroke is the leading cause of morbidity and mortality worldwide. About 87% of stroke cases are ischemic, which disrupt the physiological activity of the brain, thus leading to a series of complex pathophysiological events. Despite decades of research on neuroprotectants to probe for suitable therapies against ischemic stroke, no successful results have been obtained, and new alternative approaches are urgently required in order to combat this pathological torment. To address these problems, drug repositioning/reprofiling is explored extensively. Drug repurposing aims to identify …

Thrombotic, Inflammatory, And Hif-Regulated Genes And Thrombosis Risk In Polycythemia Vera And Essential Thrombocythemia, Radhika Gangaraju, Jihyun Song, Soo Jin Kim, Tsewang Tashi, Brandi N Reeves, Krishna M Sundar, Perumal Thiagarajan, Josef T Prchal

Faculty, Staff and Students Publications

Thrombosis is a major cause of morbidity and mortality in polycythemia vera (PV) and essential thrombocythemia (ET). The pathophysiology of thrombosis in these disorders remains unclear, and we hypothesized that upregulation of thrombotic, inflammatory, and hypoxia-inducible factor (HIF)-regulated genes may play a role in it. We performed unbiased RNA sequencing in granulocytes and platelets of PV patients and found differential expression of several thrombotic, inflammatory, and HIF-regulated genes. The expression of many of these genes positively correlated with JAK2 expression and JAK2V617F allelic burden. We then validated these findings by quantitative polymerase chain reaction analyses of selected gene transcripts in …

Proper Indwelling And External Catheter Use To Reduce Cauti's, Taylor Stephens

Scholars Week

Evidence based practice and research shows that the risk for CAUTI’s increases each day of catheterization. Research also showed that the rate of inappropriate catheterizations was very high. The conclusion made from the research recommended that catheters be removed as soon as possible in order to decrease the risk of CAUTI’s. Interventions to decrease CAUTI and inappropriate catheterization rates includes requiring a new doctors order for the continuation of an indwelling catheter every day and requiring more frequent assessment of the need for a PureWick. This method forces both the doctor and the nurse to assess the patient for the …

Utilization Of Music Therapy In The Icu Setting, Danielle York

Scholars Week

This topic was selected in the hopes of bringing awareness to music therapy and the positive benefits it can have on patients and their pain in a high stress environment. The evidence shows that music therapy can have a positive effect on patient outcomes and is a cost-effective measure that hospitals can easily implement. The education needed to implement this intervention would be geared toward patients that nurses could present to them upon pain report. The evidence proves that this is an efficient way to control patient pain and allow for a more relaxing environment.

KEYWORDS: Music, therapy, pain, education, …

Chlorhexidine: The Fight To End Ventilator-Associated Pneumonia, Jeremy Gaspari

Scholars Week

There is a major problem that affects patient outcomes in the hospital setting. This problem is ventilator-associated pneumonia. Ventilator-associated pneumonia is the second most nosocomial infection in critical care patients. A new policy is needed to ensure that interventions are being done to decrease the risk of patients getting ventilator-associated pneumonia. Ventilator-associated pneumonia also has a high risk of mortality. If interventions are being done, the risk of ventilator-associated pneumonia and mortality will decrease. Prophylactic oral care with chlorhexidine solution is show through evidence to decrease the risk of both ventilator-associated pneumonia and mortality rates. The use of ventilator bundles …

Delayed Newborn Bathing, Trisha Freudenberg

Scholars Week

Abstract:

The title of this paper is Delayed Newborn Bathing. The purpose of this project was to research the evidence and literature that supports the need for a delayed newborn bath. The project discusses the benefits of a delayed bath and what affect it has on the infant’s temperature, blood sugar/blood glucose, and exclusive breast feeding rates. Three evidence-based research studies have been presented within this project (“Impact on delayed newborn bathing one exclusive breastfeeding rates, glucose, and temperature stability, and weight loss”, “Initiative to improve exclusive breastfeeding by delaying the newborn bath”, and “Effects of delayed newborn bathing on …

Don't Worry Alone, Aldis H. Petriceks

Journal of Wellness

No abstract provided.

Covid-19 Out-Of-State Travel, March 23, 2020, University Of Northern Iowa

UNI Response to COVID-19

A memo stating that any UNI employee who traveled out to state are encouraged to self-isolate for 14 days upon their return.

2020-03-23_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 2 p.m., with COVID-19 results included as of 10 a.m.

Note on cumulative counts: This report is provisional and subject to change. As public health investigations of individual cases continue, there will be corrections to the status and details of referred cases that result in changes to this report.
Note on the deaths: Deaths must be reported by health care providers, medical examiners/coroners, and recorded by local health …

2020-03-23 A Message From Chancellor Roth, Paul B. Roth

HSC Messages from the Chancellor

No abstract provided.

A 12-Lead Ecg Database To Identify Origins Of Idiopathic Ventricular Arrhythmia Containing 334 Patients, Jianwei Zhang, Guohua Fu, Kyle Anderson, Huimin Chu, Cyril Rakovski

Mathematics, Physics, and Computer Science Faculty Articles and Research

Cardiac catheter ablation has shown the effectiveness of treating the idiopathic premature ventricular complex and ventricular tachycardia. As the most important prerequisite for successful therapy, criteria based on analysis of 12-lead ECGs are employed to reliably speculate the locations of idiopathic ventricular arrhythmia before a subsequent catheter ablation procedure. Among these possible locations, right ventricular outflow tract and left outflow tract are the major ones. We created a new 12-lead ECG database under the auspices of Chapman University and Ningbo First Hospital of Zhejiang University that aims to provide high quality data enabling detection of the distinctions between idiopathic ventricular …