Medicine and Health Sciences Commons^™

Plk1 Pbd Selective Inhibition As A Potential Cancer Therapy, Lauren E. Wilder

Senior Theses

Polo-Like Kinase 1 (PLK1) is a protein that has been found to be overexpressed in a variety of cancers including prostate and colorectal cancers, and it is often an indicator of poor patient prognosis. It has functions in initiating, maintaining, and completing mitosis, so it has an important role in controlling the proliferation of cells. PLK1 contains a highly conserved catalytic kinase domain and a less-conserved Polo Box Domain (PBD). Inhibiting the phospho-ligand binding of the PBD is a potential cancer therapy because it would prevent the cell from properly completing the cell cycle, thus inducing apoptosis. In Dr. McInnes’ …

The Role Of A Community-Driven, Structured Exercise Program On Children's And Adolescent's Quality Of Life, Padgett Singley Powe

Senior Theses

Childhood obesity is a long-standing epidemic in the United States as of 2020, and the problem is continuing to worsen. Childhood obesity has been shown to have many unhealthy effects, such as increasing prevalence of cardiovascular disease, depression, and social anxiety, which all can contribute to a worsened quality of life. Research suggests that summer is the most critical time period to combat childhood obesity is because children’s lives are less structured over the summer, which can lead to increased unhealthy behaviors, obesity, and a decrease in quality of life. The current study, the Skybrook Swim Team Study, aimed to …

Managing The Threat Of Covid-19, Susan H. Davide, Anty Lam, Christine Macarelli

Publications and Research

Oral health professionals should remain up-to-date on Covid-19 to prevent its transmission in the dental practice.

Use Of A Novel Whole-Body Imaging Approach To Predict Resting Metabolic Rates In Athletes, Nicole Vencil

College of Education and Human Sciences: Dissertations, Theses, and Student Research

Prediction of energy expenditure allows for calculation of appropriate energy requirements, which is especially important for athletes. Resting metabolic rate (RMR) is the greatest contributor to total daily energy expenditure (TDEE) and is typically measured via indirect calorimetry. Indirect calorimetry is not always available, which results in the need for predictive equations. Most predictive equations have been developed with participants resembling the general population and have not been found to be appropriate for athletes, as they may incorrectly predict RMR due to the unique differences of body composition between athletes and the general population. The purpose of the present study …

Japanese Immigrant Families' Experiences Of Accessing Healthcare In The Us, Rei Yamada, Maki Kano-Lueckerath, Md, Walter K. Kraft, Md

Student Papers, Posters & Projects

No abstract provided.

Computed Tomographic Findings In Ruptured Basilar Tip Aneurysms, Dullaya Prukrudee, Jarturon Tantivatana, Krittanon Lertutsahakul

Chulalongkorn Medical Journal

No abstract provided.

Prevalence Of Neuropsychiatric Symptoms In Patients With Mild Cognitive Impairment At King Chulalongkorn Memorial Hospital, Angvara Vongudommongkol, Solaphat Hemrungrojn

Chulalongkorn Medical Journal

No abstract provided.

Premorbid Personality Traits And Neuropsychiatric Symptoms In Patients With Mild Cognitive Impairment, Parin Tieosirisap, Daruj Aniwattanapong

Chulalongkorn Medical Journal

No abstract provided.

Prevalence Of Vitamin D Deficiency In Patients With Schizophrenia At King Chulalongkorn Memorial Hospital, Thanaporn Phengkaew, Atapol Sughondhabirom

Chulalongkorn Medical Journal

No abstract provided.

Determinants For Methamphetamine Abstinence Of Short-Term And Long-Term Inpatient Treatments For Methamphetamine Use, Puttipong Prasartpornsirichoke, Rasmon Kalayasiri

Chulalongkorn Medical Journal

No abstract provided.

Effect Of Wii Balance Board And Motor Imagery On Balance And Muscle Strength In Football Players, Adithep Watkhum, Onuma Boonyarom, Kanokwan Srisupornkornkool

Chulalongkorn Medical Journal

No abstract provided.

Bioactive Compounds, Antioxidant, And Antineoplastic Activities Of Asian Herbs, Tahira Yasmin, Muhammad Azam, Ummaimah, Muhammad Asim Raza Basra

Chulalongkorn Medical Journal

No abstract provided.

Total Thyroidectomy As A Treatment Of Acute Suppurative Thyroiditis, Pasurachate Samorn

Chulalongkorn Medical Journal

No abstract provided.

Noise-Induced Hearing Loss (Nihl) And Sound Control Standards For Stone Crushers, Pariyanuch Junsatitanon, Krit Pongpirul

Chulalongkorn Medical Journal

No abstract provided.

Effects Of Neuromuscular Training And Electrical Stimulation On Ankle Stability And Muscle Strength Of Peroneus Longus In Rock Climbers, Khingkhan Saleephon, Onuma Boonyaroma, Chaiyong Jorrakate

Chulalongkorn Medical Journal

No abstract provided.

Indoor Air Bacterial And Fungi Bioburden In An Electronic Factory, An Office And A Winery In Malaysia, Adeola Folayan, Stephen Ambu

Chulalongkorn Medical Journal

No abstract provided.

Comparisons Of Celiac Disease And Non-Celiac Gluten Sensitivity, Victoria Thomas

Senior Honors Theses

Celiac disease (CD) and non-celiac gluten sensitivity (NCGS) are often confused or grouped together due to their commonalities. However, this is careless behavior because there are clinically significant differences between the two diseases. Similarities between them include varying degrees of damage or permeability in the lining of the small intestine, involvement of the innate immune system, alleviation of symptoms upon implementation of a gluten-free diet (GFD), and the possibility for complications if the pathology is not adequately treated. Despite these similarities, minor details such as the following make CD and NCGS worth differentiating: the question of gluten as the true …

The Utility Of Cervical Spine Bracing As A Postoperative Adjunct To Multilevel Anterior Cervical Spine Surgery, Ian F. Caplan, Saurabh Sinha, Benjamin Osiemo, Scott Mcclintock, James M. Schuster, Harvey Smith, Gregory Glauser, Nikhil Sharma, Ali K. Ozturk, Zarina S. Ali, Neil R. Malhotra

Mathematics Faculty Publications

Background: Use of cervical bracing/collar subsequent to anterior cervical spine discectomy and fusion (ACDF) is variable. Outcomes data regarding bracing after ACDF are limited. Here, we study the impact of bracing on short-term outcomes related to safety, quality of care, and direct costs in multilevel ACDF.

Methods: Retrospective cohort analyses of all consecutive patients undergoing multilevel ACDF with or without bracing from 2013 to 2017 was undertaken (n = 616). Patient demographics and comorbidities were analyzed. Tests of independence and logistic regressions were used to assess differences in length of stay (LOS), discharge disposition (home, assisted rehabilitation facility [ARF], or …

Dr. Julius Hallervorden’S Role In Nazi “Euthanasia”, Kylee Yturralde

University Libraries Award for Undergraduate Research

On the path to becoming a doctor, many undergraduate students focus their studies exclusively on STEM classes. This prepares students well for medical school but disregards the significance of Humanities courses that are imperative to becoming ethical physicians who can relate and advocate for those around them. I spent the last one and a half years investigating Dr. Julius Hallervorden, a famous 20th century neuropathologist, who became complicit in criminal acts perpetrated in the Nazi “euthanasia” program. Dr. Hallervorden was not tried in the Nuremberg Doctors’ Trial. Prosecutors determined there was insufficient evidence to convict him of murdering patients. After …

Current Strategies In Prevention Of Postoperative Infections In Spine Surgery., Kivanc Atesok, Efstathios Papavassiliou, Michael J Heffernan, Danny Tunmire, Irina Sitnikov, Nobuhiro Tanaka, Sakthivel Rajaram, Jason Pittman, Ziya L Gokaslan, Alexander Vaccaro, Steven Theiss

Rothman Institute Papers

Study Design: Narrative review.

Objectives: Postoperative surgical site infections (SSIs) are among the most common acute complications in spine surgery and have a devastating impact on outcomes. They can lead to increased morbidity and mortality as well as greater economic burden. Hence, preventive strategies to reduce the rate of SSIs after spine surgery have become vitally important. The purpose of this article was to summarize and critically analyze the available evidence related to current strategies in the prevention of SSIs after spine surgery.

Methods: A literature search utilizing Medline database was performed. Relevant studies from all the evidence levels have …

The Optimal Treatment Time Of Dry Cupping Therapy To Induce Changes In Local Blood Flow At The Upper Trapezius, Emily Schultz

Theses and Dissertations

Context: Musculoskeletal neck and shoulder pain is a prevalent condition with nearly two-thirds of the population experiencing it sometime in their lifespan; factors may include activity level, sex, stress, and postural deficits. The treatment varies, but recent focus is on complementary and alternative medicine. Cupping therapy is a type of alternative medicine that involves a cup placed on the skin secured by suction for an unspecified amount of time. This therapy has been around for thousands of years, but there is much speculation around its true mechanisms on the human body; theories indicate that cupping therapy has an effect on …

Patient, Hospital And State-Level Policy Characteristics Associated With Prevalence Of Treating Opioid Use Disorder In United States Emergency Departments, Rafeek Adeyemi Yusuf

Dissertations and Theses (Open Access)

The opioid crisis in the United States was declared a public health emergency due to escalating and untoward human, financial, and systemic consequences and effects on the nation. Opioid use disorder (OUD) comprising opioid abuse and dependence is devastating because of its associated chronic relapsing nature, overutilization of healthcare services, rising morbidity and mortality rates, and high cost of care. Efforts to address this have not made significant positive impacts. It is thus imperative to reassess the influence of factors associated with OUD. This study answered the question, what patient-, hospital-, and state-level policy factors were associated with prevalence of …

Identifying Risk Factors For Chronic Kidney Disease Of Unknown Origin In Six Central American Countries And Houston, Texas, Erika Figueroa-Solis

Dissertations and Theses (Open Access)

Chronic kidney disease (CKD) is a public health problem that is recognized worldwide. The type of CKD in Central America does not fit the “usual” CKD encountered in countries with upper middle-income economies, and is also often referred to as CKD of undetermined cause (CKDu). Evidence suggests that CKDu is a disease of occupational origin that can be brought on by a combination of exposures: hot environments, high physical job demands, inadequate hydration protocols, and effects of other nephrotoxic agents. Many gaps remain in knowledge related to CKDu and its putative risk factors, geographic distribution, distributions of renal function in …

Managing Chronic Pain Through Advancements In Transcranial Brain Stimulation Technology Currently Used For Depression, Ashley N. Skinner

Honors Thesis

The purpose of this thesis is to bring attention to alternatives to using analgesics or painkillers and potentially addictive opioid analgesics. Transcranial Magnetic Stimulation (TMS) has been proven successful in treating medication-resistant depression. This literature review will look at the links between pain and depression and examine adaptations to TMS coils in hopes of being able to stimulate the regions of the brain that interpret pain. By looking at current advancements in TMS, we can work towards adapting TMS to stimulate deeper regions. The final section of this thesis will examine how making these alternatives more popular will impact pain …

Our Multi-Pandemic, Larry M. Starr

School of Continuing and Professional Studies Coronavirus Papers

Application of systems thinking to identify and understand complex problems and to discover innovative ways to intervene has been advocated separately within public health, education, finance, and many other spheres of society. We need it now for the multi-pandemic.

No Double Trouble: How To Reopen The Economy., Larry Hirschhorn, Phd

School of Continuing and Professional Studies Coronavirus Papers

This policy introduces a measure of choice, consonant with our culture. Those younger than 65 can make their own personal tradeoffs between heath and livelihood, while older people, knowing that the virus will be spreading more quickly through the population will be even more cautious, thus preventing their early deaths. We return decisions to people while ensuring that the sum total of decisions does not overwhelm our hospitals. One felicitous result of this policy is that the virus will spread more quickly through the healthier population. This means that when the elderly re-engage in social life they will encounter fewer …

Systems View Of Coronavirus, Sung Won Paek, Larry M. Starr

School of Continuing and Professional Studies Coronavirus Papers

No one envisioned the kinds of problems that emerged from the novel coronavirus nor had anyone considered its interactive scope. Now is the time to begin to redesign our processes and systems so that when confronted again we can cope and navigate better. Everyone needs to be a partner in these redesigns and each of the health, social, educational, and other systems must be integrated because it is their interconnections that coproduce and give meaning to our lives.

Expert Search For "Summary Of The Evidence On The Safety, Efficacy, And Effectiveness Of Human Papillomavirus Vaccines", Kelly K. O'Brien Mslis

Expert Search Strategies

This search strategy was constructed to support the research for the peer reviewed article listed above. Full article abstract:

Background

This objective of this umbrella review was to summarize the evidence on safety, efficacy, and effectiveness of human papillomavirus (HPV) vaccines in the general population.

Methods

The authors conducted a literature search and selected systematic reviews if they were published from January 2006 through November 2018, included randomized controlled trials or observational studies, related to the general population, and evaluated HPV vaccine-related clinical outcomes. The authors independently and in duplicate screened literature, extracted data, and appraised reviews using AMSTAR 2, …

Reflections On The Effects Of Federalism On Opioid Policy, Matthew B. Lawrence

Dickinson Law Review (2017-Present)

No abstract provided.

Mhpaea & Marble Cake: Parity & The Forgotten Frame Of Federalism, Taleed El-Sabawi

Dickinson Law Review (2017-Present)

No abstract provided.