Medicine and Health Sciences Commons^™

N-Terminal Pro-Brain Natriuretic Peptide As A Biomarker For Differentiating Cardiac And Pulmonary Disease In Term Neonates With Respiratory Distress, Azza M. Ahmed, Nagwa Abd El-Ghffar Mohamed, Enas M. Abdelhamid, Randa I. Taha, Maha M.A. Abo-Hashish

Journal of the Saudi Heart Association

Objective: Brain natriuretic peptide (BNP) is synthesized in the cardiac ventricles and released in response to volume or pressure load. The aim of the study was to determine whether plasma level of N-terminal pro BNP (NT-pro BNP) can distinguish between cardiac and pulmonary disease (PD) among neonates with respiratory distress (RD). Patients and methods: The study included 48 term neonates in the first month of life with signs of RD. They were recruited from Neonatal Intensive Care Unit of Al-Galaa Teaching Hospital. Twenty-six healthy neonates were included as a control group. The degree of RD was assessed using SilvermaneAnderson score. …

Systemic Immune-Inflammation Index Predicts Mortality In Infective Endocarditis, Hicaz Z. Agus, Serkan Kahraman, Cagdas Arslan, Ceren Yildirim, Mehmet Erturk, Ali K. Kalkan, Mustafa Yildiz

Journal of the Saudi Heart Association

Objectives: The aim of our study was to evaluate the usefulness of systemic immune-inflammation index (SII) at admission in predicting in-hospital mortality in patients with infective endocarditis. Methods: 133 definite IE patients (≥18 years) according to modified Duke criteria, treated in our tertiary care hospital between December 2009 and May 2019, were retrospectively analysed. Symptoms, comorbidities, predisposing valvular diseases, prosthetic valve, device, history of injectable drug use, blood culture results, echocardiography findings, and complications were collected. We calculated the SII as follows: SII¼platelet count£neutrophil count/lymphocyte count at admission. Results: The median age of the patients was 56 (40e66) years. Prosthetic …

Comparison Between Two Protocols For Deflation Of The Tr Band Following Coronary Procedures Via The Radial Route, Hassan Al Riyami, Adil Al Riyami, Sunil K. Nadar

Journal of the Saudi Heart Association

Aim: Coronary interventions are increasingly being performed via the radial rather than femoral route because of the lower complication rate. Compression devices such as the TR band are used to achieve hemostasis after the procedure. At present, there are no clear protocols for the deflation of the band. In this study we compared two protocols (early deflation with increased intervals vs. late deflation with smaller intervals) in terms of total time to band removal and complications, and patient and staff satisfaction. Methods: All patients who underwent a transradial coronary procedure and had a TR band fitted were enrolled into the …

The Use Of Antidepressants In Patients With Heart Failure, Norah Alsumih, Rahaf Alqahtani, Faisal Almutairi, Rakan Faraj, Turki Alsubeai, Ahmed Alghanim, Shmylan Alharbi, Hind Almodaimegh

Journal of the Saudi Heart Association

Background: Heart failure (HF) is a chronic disease affecting patients’ quality of life (QoL) and may cause depression. Recent studies reported that the prevalence of depression in patients with HF is 21.5%. Antidepressants, mainly selective serotonin reuptake inhibitors, are usually prescribed for HF patients diagnosed with depression. Some evidence supports antidepressant’s role in improving symptoms by enhancing the psychological aspect of their QoL. Depression screening and treatment are important in the multidisciplinary management; however, their survival benefits are inconsistent. In our study, we aim to investigate the prevalence of depression and the use of antidepressants in patients with HF as …

Effects Of Cardiopulmonary Bypass Perfusion Temperature On Perioperative Renal Function In Adult Patients Undergoing Cardiac Surgery, Jayavelan Ramkumar, Girish Gopinathan, Karthick Kavin, Ramkumar Shanmugasundaram, George M. Stephen, Annie C. Pragasam, Periyasamy Thangavel

Journal of the Saudi Heart Association

Aims and objective: The primary objective of this investigation was to study the effects of cardiopulmonary bypass (CPB) perfusion temperature on renal function parameters [serum creatinine, creatinine clearance, urine albumin, urine protein, and urine albumin/creatinine ratio (ACR)]. The secondary objective was to detect renal complications of CPB. Materials and methods: This is a prospective longitudinal study of 30 adult patients (17 men, 13 women; mean age, 53.37 ± 16.02 years) who underwent valvular heart surgery [with or without coronary artery bypass grafting (CABG)]. Serum creatinine, creatinine clearance, urine protein, urine albumin, and urine ACR were collected during CPB (at 28 …

Right Ventricular Functions In Subphenotypes Of Sickle Cell Disease, Ilham Youssry, Mohamed F. Shaltout, Antoine F. Abdelmassih, Carolyne Ghobrial, Mohammad Nabih, Ramy Doss, Raghda Fouda, Amal El-Sisi

Journal of the Saudi Heart Association

Objectives: Sickle cardiomyopathy is the most important cause of death in patients with sickle cell disease (SCD). Based on recent evidence, SCD can be divided into two subphenotypes, namely, the viscosity vaso-occlusion (VVO) subphenotype and the hemolysis endothelial dysfunction (HED) subphenotype. The aim of our series is to study right ventricular (RV) functions in both subphenotypes. Methods: Echocardiography including conventional and tissue Doppler imaging as well as speckle tracking echocardiography was performed in 50 patients (23 from the VVO subgroup and 27 from the HED subgroup) based on a serum lactate dehydrogenase (LDH) level below or above 270 U/L, respectively, …

Exercise-Based Cardiac Rehabilitation For Post Coronary Artery Bypass Grafting: Its Effect On Hemodynamics Response And Functional Capacity Using Incremental Shuttle Walking Test: A Retrospective Pilot Analysis, Ahmad Osailan, Walid K. Abdelbasset

Journal of the Saudi Heart Association

Background: Coronary artery bypass grafting (CABG) is a common surgical procedure for the restoration of blood flow into stenotic or blocked coronary arteries. Cardiac rehabilitation has been implemented to some extent worldwide for the management of postoperative CABG. However, studies about the effect of exercise training on hemodynamic responses of the heart using the Incremental Shuttle Walking (ISWT) test are limited in Saudi Arabia. Objectives: To investigate the effect of exercise-based cardiac rehabilitation (Phase 3, hospital-based) on some hemodynamic responses including blood pressure, heart rate (HR) and heart rate recovery (HRR), and rate pressure product (RPP) using ISWT on post-CABG …

An Observational Comparison Of Distal Radial And Traditional Radial Approaches For Coronary Angiography, Anupam Bhambhani, Salil Pandey, Aditi N. Nadamani, Kartikey Tyagi

Journal of the Saudi Heart Association

Background: Several studies have recently reported regarding feasibility and safety of distal transradial access (d-TRA) in the anatomical snuff-box (ASB); however, literature comparing it with the conventional TRA at the wrist (w-TRA) is sparse. This study compares the technical efficiency and safety of ASB and wrist approaches for TRA for coronary angiography (CAG) and evaluates the radial artery (RA) anatomy at these sites. Methods: Two hundred consecutive patients undergoing CAG via w-TRA or d-TRA (100 in each group) were investigated. The primary endpoint was comparison of procedural efficiency of the two methods, defined as CAG completion from the intended access …

Occurence Of Left Main Occlusion On Tuesday: Chronobiology Of Acute Myocardial Infarction, Gianluca Rigatelli, Marco Zuin

Journal of the Saudi Heart Association

Objectives: The existence of a “weekend effect” for onset of acute myocardial infarction (AMI) has been suggested in the past, but the relation with the culprit vessel has not been investigated. MI due to left main coronary artery lesion represents a particularly serious life-threatening condition. Our study was aimed to assess the chronobiology of admission to the emergency department for AMI considered to be induced by a left main culprit lesion. Methods: We retrospectively reviewed patients who experienced an AMI due to a left main culprit lesion between January 1, 2008 and January 1, 2018 stratifying them according to the …

A Real-Life Correlation Between Clinical Syntax Score Ii And Carotid Intima-Media Thickness In Patients With Stable Coronary Artery Disease, Mahmoud Abdelnabi, Abdallah Almaghraby, Ozge O. Tok, Tugba K. Oz, Yehia Saleh, Ahmed Morsi, Hiatham Badran

Journal of the Saudi Heart Association

Background: SYNTAX score II (SSII) is an update of the established SYNTAX score (SS) that uses clinical variables such as age, sex, creatinine clearance, left ventricular ejection fraction, chronic obstructive pulmonary disease, and peripheral arterial disease. Furthermore, SSII has been proven to be a more powerful predictive tool than SS in patients with complex coronary artery disease (CAD). Carotid õntima-media thickness (CIMT) is a widely used noninvasive evidence for subclinical or early atherosclerosis, and it was proved to be an independent predictor for cardiovascular events. Most of the previously published articles studied the association between the CIMT with old cardiovascular …

Safety Of Returning Patients Immediately To Their Originating Hospitals After Primary Percutaneous Coronary Intervention, Rahim Gul, Maksymilian P. Opolski, Mufti Akif, Mehboob A. Dar, Yasir Beshir, Haitham Sakr, Hassan Khalaf, Akram Eldesoky, Osama A. Smettei, Tariq I. Soomro, Mohammed Saied, Asim Ganawa, Rami M. Abazid

Journal of the Saudi Heart Association

Introduction: The objective of this study was to evaluate the safety and feasibility of the immediate return of patients with ST-elevation myocardial infarction (STEMI) to their originating hospitals after primary percutaneous coronary intervention (PPCI). Methods: This was a prospective study, conducted between January 2014 and December 2017. All patients with STEMI who were transferred for PPCI and returned back to their referring hospitals (RB group) were included and compared to the onsite STEMI population (OS group). Patient’s demographics, PPCI data, bleeding and adverse cardiovascular events (ACEs) occurring during transfer, hospital stay, and at 1-month follow-up were recorded. Results: A total …

Editorial, Hani Najm

Journal of the Saudi Heart Association

No abstract provided.

Faculty Instruction Face Shield Project, David Holden, John Schneiderhan

Michigan Tech 3D Designs

Early in the spring of 2020 project contributors David Holden and John Schneiderhan began test printing a variety of open source Personal Protective Equipment (PPE)/Covid related items that could help protect or prevent the spread of the emerging virus. With assistance from Pete Baril of the Western Upper Peninsula Health Department (WUPHD) approval was obtained for the face shields to be used in the health care and nursing homes in the area. With the support and approval from university and library administration efforts were coordinated with Dr. Joshua Pearce and the students from the MOST lab to concentrate on the …

Coronavirus Closes In On Rohingya Refugees In Bangladesh’S Cramped, Unprepared Camps, Saleh Ahmed

University Author Recognition Bibliography: 2020

Coronavirus is spreading quickly in densely populated Bangladesh, despite a nationwide shutdown put in place a month ago.

This preventive measure has proven challenging to implement due to lack of awareness of the coronavirus and the absence of a social safety net. Extreme poverty also forces many Bangladeshis to keep working and looking for food despite the risks. Bangladesh had 2,948 confirmed COVID-19 cases as of April 20.

The disease has not yet spread into the refugee camps that house the Rohingya Muslims who fled ethnic violence in Myanmar in 2017, according to a recent update from the humanitarian organizations …

Home, Rachel L. Knight

Reflections, Poetry, Photos, and other Writings

I wrote this poem as a way of reflecting on my feelings about being “home” due to COVID-19. The accompanying photograph is my desk in my bedroom at “home” as it was a few weeks ago (it’s messier now).

Selinexor Hyperactivates Akt And Induces Its Nuclear Accumulation, Erin Lawrence

Honors Scholars Collaborative Projects

Selinexor is currently being used in several clinical trials for cancer and has shown anti-cancer effects in combination with other chemotherapies. Clinical trials evaluating the use of selinexor in the treatment of triple negative breast cancer are limited, but in vitro studies show promising results in its ability to kill triple negative breast cancer cells. The mechanism by which this occurs, however, is not understood. The goal of this research was to determine the mechanism by which selinexor kills BT- 549 triple negative breast cancer cells.

Governor's Proclamation Emphasizes Teleworking For Northeastern Iowans, April 20, 2020, University Of Northern Iowa

UNI Response to COVID-19

A memo encouraging all employees who can should work from home and what steps employees should take if they must come to campus.

2020-04-20_Michiganoverview_Covidcounts, Michigan Department Of Health & Human Services

Michigan COVID-19 Confirmed Cases by Date of Onset Data

Data was captured from the Cumulative Data link of Michigan's Coronavirus webpage, under the url https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173_99207---,00.html.

The website contained the table Count of Confirmed COVID-19 Cases by Date of Onset , sorted by Michigan Preparedness Region. It also contained 18 charts, including the count of confirmed Covid-19 cases by date of onset in the state overall as well as in each preparedness region,and the normalized rate of Covid-19 cases per 1,000,000 residents in both the state and in each preparedness region.

Acue Effective Teaching Practices: Module Reflections, Nancy Wolf

Q2S Enhancing Pedagogy

This is a collection of ACUE (Association of Colleges and University Educators) implementation and reflection assignments. The Teaching Resource Center partnered with ACUE and the corresponding modules were offered to a set of accepted instructors at CSUSB. These assignments focused on teaching practices designed to enhance the learning experience for both on-ground and online instruction.

CSUSB – CNS – Department of Nursing Full-time Lecturer, Nancy Wolf, completed a 25-module course in effective teaching practices requiring the implementation of evidence-based instructional approaches. The credential is co-issued by the American Council on Education and distinguishes faculty for their commitment to educational excellence …

2020-04-20_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

2020-04-20_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., with COVID-19 results included as of 10 a.m.

Note on cumulative counts: This report is provisional and subject to change. As public health investigations of individual cases continue, there will be corrections to the status and details of referred cases that result in changes to this report.
Note on the deaths: Deaths must be reported by health care providers, medical examiners/coroners, and recorded by local health departments …

Effect Of Amodiaquine On Gene Expression And Apoptosis In Colorectal Cancer Cells, Holly Pyles

Honors Scholars Collaborative Projects

This study used gene expression analysis to explore the specific response to amodiaquine in HCT116 colorectal cancer cells. Real-time PCR revealed that 20 human stress and toxicity genes were upregulated by at least 3 fold in HCT116 colorectal cancer cells treated with AMQ. Of these 20 upregulated genes, 9 were found to be pro-apoptotic and 2 were DNA damage repair genes, which supports our original hypothesis that amodiaquine is inducing a stress response in these cells. These results are consistent with previous research done by Qiao et al. (2013), as DNA damage repair genes were among the genes upregulated in …

Unnatural Disasters: Environmental Trauma And Ecofeminist/Ecowomanist Resistance In Zora Neale Hurston’S Their Eyes Were Watching God And Jesmyn Ward’S Salvage The Bones, Sarah Anne Pfitzer

Honors Scholars Collaborative Projects

No abstract provided.

Sleep Deprivation And High-Fat Diet During Adolescence Protect Stress Effects On Object Memory During Adulthood, Karina Glushchak

Honors Scholars Collaborative Projects

No abstract provided.

The Effects Of Language Barriers With Hispanic Patients In The Nashville, Rachel Poston

Honors Scholars Collaborative Projects

The existence of language barriers in the health care setting is a vital topic of study. This study assesses language barriers from the perspective of nurse-patient relationships, focusing on the Hispanic patient population in the Nashville, Tennessee area. A survey was designed using the Theory of Bureaucratic Caring by Marilyn Ray (2006) to investigate the current success, according to nursing perspectives, of healthcare facilities support of Hispanic patients to ensure quality outcomes and comprehension of care. The research design for this study was a non-experimental, descriptive study using a cross-sectional survey. The researcher used themes from the Theory of Bureaucratic …

An Intact C-Terminal End Of Albumin Is Required For Its Long Half-Life In Humans., Jeannette Nilsen, Esben Trabjerg, Algirdas Grevys, Claudia Azevedo, Stephen O Brennan, Maria Stensland, John J Wilson, Kine Marita Knudsen Sand, Malin Bern, Bjørn Dalhus, Derry C. Roopenian, Inger Sandlie, Kasper Dyrberg Rand, Jan Terje Andersen

Faculty Research 2020

Albumin has an average plasma half-life of three weeks and is thus an attractive carrier to improve the pharmacokinetics of fused therapeutics. The half-life is regulated by FcRn, a cellular receptor that protects against intracellular degradation. To tailor-design the therapeutic use of albumin, it is crucial to understand how structural alterations in albumin affect FcRn binding and transport properties. In the blood, the last C-terminal residue (L585) of albumin may be enzymatically cleaved. Here we demonstrate that removal of the L585 residue causes structural stabilization in regions of the principal FcRn binding domain and reduces receptor binding. In line with …

Ada News - 04/20/2020, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Impact Of Meaningful Recognition On Work Environment Perception Of Critical Care Nurses, Kristin Meinershagen

Dissertations

Problem: Absence of nursing staff recognition can lead to compassion fatigue, burnout, job dissatisfaction, and increased turnover rate resulting in high costs for hospitals. Meaningful recognition has been found to decrease compassion fatigue and reduce burnout. A meaningful recognition program was implemented over a 3-month period for staff nurses in an Intensive Care Unit (ICU) at a large midwestern, metropolitan hospital to determine its effect on nurse’s perception of work environment and turnover rate in the ICU.

Methods: This was an observational, descriptive, cohort design utilizing the AACN Healthy Work EnvironmentSurvey instrument for assessing results before and after implementation …

Maternal Exposure To Δ9-Tetrahydrocannabinol Impairs Female Offspring Glucose Homeostasis And Endocrine Pancreatic Development In The Rat., Ryan Gillies, Kendrick Lee, Sebastian Vanin, Steven R Laviolette, Alison C Holloway, Edith Arany, Daniel B Hardy

Physiology and Pharmacology Publications

Recent reports indicate that 7% of pregnant mothers in North America use cannabis. This is concerning given that in utero exposure to Δ9-tetrahydrocannabinol (Δ9-THC), the main psychoactive component in cannabis, causes fetal growth restriction and may alter replication and survival of pancreatic β-cells in the offspring. Accordingly, we hypothesized that maternal exposure to Δ9-THC during pregnancy would impair postnatal glucometabolic health of offspring. To test this hypothesis, pregnant Wistar rats were treated with daily intraperitoneal injections of either 3 mg/kg Δ9-THC or vehicle from gestational day 6 to birth. Offspring were subsequently challenged with glucose and insulin at 5 months …

2020-04-20 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Ingrid Hendrix, Lori D. Sloane, Anastasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Hannah Groves, Rachel D. King, Estefania Montanez, Malik Alqawasmi, Samuel Anyona, Evans Raballah, Elly Munde, Cristian Bologa, Alexandra Yinglng, Gregory Mertz, Kristine Tollestrup, Orrin Myers, Douglas J. Perkins

HSC Covid 19 Briefings

Executive Summary:

NM highlights. Immigration detention centers. US outbreak perceptions. States lockdown protests. Drones sample transport. Black market antivirals. NZ eases lockdown. Germany partial reopening. Low temperature/humidity favors transmission. Wastewater epidemiology. Contact tracing privacy. D-dimer severity prediction. China fatality factors. Group testing. High throughput testing. Pet testing. WHO misinformation countermeasure. WHO produce washing. Public health strategies. Fellows education adaptations. Mental health priorities. Practice guidelines: immunocompromised cancer patients, IBD, tracheostomy, trauma surgery, neurovascular management, head & neck cancer surgery, long-term care, and respiratory home care. Remdesivir macaque clinical benefit. Hydroxychloroquine meta-analysis. Heparin anticoagulant therapy. Hypothiocyanite hypothesis. 36 new clinical trials. Neutrophil …