Medicine and Health Sciences Commons^™

The Effect Of Staphylococcus Aureus Exposure On White-Tailed Deer Trabecular Bone Stiffness And Yield, Emily Brooke Long

Graduate Theses

Osteomyelitis is an infection of the bone or bone marrow caused by the infiltration of bacteria, resulting in destructive inflammation, bone necrosis and abnormal bone remolding. With a growing number of osteomyelitis diagnoses, many of which are linked to Staphylococcus aureus (S. aureus), it is imperative to understand the pathology of S. aureus in relation to bone to provide better diagnostics and patient care. While the cellular mechanisms of S. aureus and osteomyelitis have been studied, little information exists on the biomechanical effects of such infections. We postulated that exposure to S. aureus for 72 hours would significantly decrease both …

Examination Of Perceptions Of Weight Loss And Weight Loss Methods, Andrew Seiber

Electronic Theses and Dissertations

The purpose of this study was to examine individuals’ perceptions of weight loss and weight loss methods. Respondents were employees and customers attending health/wellness events at local supermarkets in June, July, and August 2019. Participants completed a survey to assess their understanding and perceptions of weight loss and methods used to achieve weight loss. The majority of participants were white females, 60 years or older with a college degree and a Body Mass Index (BMI) classified as overweight or obese. Data revealed most participants had a variety of misconceptions relating to weight loss and weight loss methods that were obscure …

The Impact Of Intermittent Auscultation And Physiologic Labor Support Education For Nurses On Patient Satisfaction And Nurse Self-Efficacy, Heather N. Soper

Doctoral Dissertations and Projects

Knowledge and implementation of intermittent fetal auscultation (IA)and labor support mechanisms in the hospital setting are becoming a lost art. Nurses are well-trained on how to utilize technology and perform medical interventions for laboring patients, but are losing the confidence and skills necessary to promote normal, physiologic births for low-risk women. In order to address these concerns, an evidence-based practice project was piloted in a hospital in Virginia. Nurses were trained on the science, clinical application, and outcomes of both intermittent auscultation and continuous electronic fetal monitoring for low-risk women; education was also focused on labor support mechanisms and the …

Artifact Identification For Blood Pressure And Photoplethysmography Signals In An Unsupervised Environment, Pooi Khoon Lim

Student Works (2020-2029)

Physiological signals play a significant role in clinical diagnosis, it always acts as a major input of a decision support system. However, the physiological signal is easily corrupted by different factors especially motion artifacts. Several research works have been tried to recover the underlying physiological signal by suppressing the artifact. However, not much attention has been paid to situation where the artifact is too extreme and the artifact suppression is not possible. In this situation, physiological signal quality must be evaluated before any further assessment. In this study, an automated artifact detection algorithm was developed for Blood Pressure and PPG …

The Use Of Guedel Airway For Naso-Orogastric Tube Insertion In Patients With Covid-19. A Way To Minimize Aerosol Generation, Faraz Shafiq, Dileep Kumar

Department of Anaesthesia

No abstract provided.

Potential Barriers Amongst Health Care Professionals Of Pakistan In Managing Covid-19 Patients, Muhammad Irfan Ul Haq, Faraz Shafiq, Haris Sheikh

Department of Anaesthesia

Objectives: To evaluate basic knowledge of Health Care Professionals (HCPs) of Pakistan in managing COVID 19 patients. It includes information regarding infection control measures, administrative and professional support. This was followed by evaluation of psychological factor that can act as a barrier in effective management of these patients.
Methods: The survey was conducted on line using Google Form. After approval from hospital ethical committee survey link was disseminated to HCPs using social media.
Results: Four hundred fifteen HCPs were participated. Most of them were younger than 30 years and majority of them were postgraduate trainees. Results showed gaps in the …

The Effect Of Β-Caryophyllene On Isoproterenol-Induced Myocardial Infarction, Farah M. Jamal Laham

Theses

Cannabinoid type 2 receptors (CB2), a key member of the endocannabinoid system have recently emerged as a crucial therapeutic target for cardiovascular diseases (CVDs). Downregulation of CB2 receptors has been witnessed in various cancers, neurological and cardiovascular disorders. Thus, the activation of CB2 receptors may protect against ISO-induced myocardial infarction (MI) in rats. The present study investigates the cardioprotective effect of a selective cannabinoid type 2 receptor agonist β-caryophyllene (BCP), a dietary phytocannabinoid, and a natural bicyclic sesquiterpene against isoproterenol (ISO)-induced MI in rats. Male albino Wistar rats were pre-and co-treated with β-caryophyllene (50 mg/kg, orally) twice daily for 10 …

Examining The History Of Racial Groups To Understand Health Disparities In Monterey County, Virginia Murillo

Capstone Projects and Master's Theses

The Monterey County Health Department’s Health Equity Scholars Academy aspires to train health workforce leaders to prioritize equity into services. Health inequities occur when there are systematic differences in the health statuses of different populations. These disparities perpetuate negative health outcomes for minority groups. In Monterey County, too few public employees are aware of the types and pervasiveness of health inequities experienced by a significant proportion of the population. A timeline was developed to provide a more accessible way to educate public employees about significant events and policies affecting Monterey County resident’s health. Content from the timeline has been incorporated …

Increasing Accessibility To Key Social Determinants Of Health In Monterey County, Tabitha Vargas

Capstone Projects and Master's Theses

Monterey County Health Department’s Planning, Evaluation, and Policy Unit provides agency-wide support in promoting health equity. Obesity and diabetes rates in Monterey County are too high and there needs to be an increase of accessible data, which may help increase targeted prevention services. A health brief was developed for the purpose of increasing access to county-wide obesity and diabetes data and increasing knowledge of the role of how social determinants of health may affect health outcomes. A survey was conducted to measure the effectiveness of the health brief with results demonstrating that 100% of respondents agreed that the brief was …

Analysis Of Gene Expression In Early-Stage Pancreatic Cancer And Investigation Of 1,2,3,4,6-Penta-O-Galloyl-Β-D-Glucopyranoside As A Therapeutic, Zachary R. Heinzman

Honors Program Theses

Pancreatic cancer (PC) is one of the deadliest cancers among both men and women. However, if it is detected early, there is a significant increase in the 5-year survivability of the disease1 . Currently, there are no truly efficient detection mechanisms available to detect earlystage PC when treatment options are more viable. The first objective of this project was to determine the expression levels of AHNAK2, IGHG3, EPPK1, CTHRC1, CEL, PLA2G1B, and GNMT—all known to be aberrantly expressed in PC cell lines—in early-stage PC tissue and assess the feasibility of their use as potential biomarkers for PC. To accomplish this, …

Treatment Of Proximal Hamstring Tendinopathy With Active Release Technique In Collegiate Track Athletes: A Case Series, Madison Hagedorn

Honors Program Theses

It is imperative that healthcare professionals implement evidence-based practice into their professional practice to provide the best patient-centered care. Evidence-based practice is a systematic approach to making decisions about patient care that includes patients’ preferences and values, clinical expertise acquired through clinical experience and practice, and relevant research evidence in making decisions about patient care. A common challenging condition for clinicians to treat is a chronic injury. Proximal hamstring tendinopathy (PHT) is a common chronic condition among running athletes that is often characterized by pain in the upper hamstring or buttocks during repetitive activities. Proximal hamstring tendinopathy is typically treated …

Respiratory Differences In Spontaneous And Scripted Speech Among Bilingual Adults, Anna Irene Sagan

Honors Program Theses

This investigation explored respiratory differences between a speaker’s first language (L1) and second language (L2) during spontaneous and scripted speech in six adult bilingual speakers (two native bilingual speakers and four non-native bilingual speakers). Respiratory kinematic data using Respitrace respiratory inductance plethysmography and acoustic recordings were collected during five tasks: tidal breathing at rest, scripted speech in L1, spontaneous speech in L1, scripted speech in L2, and spontaneous speech in L2. Results indicated a significant interaction effect between proficiency and syllables produced during spontaneous speech, but no other significant differences were found among inspiratory/expiratory duration, task, proficiency or language. The …

Predicting Disease Progression Using Deep Recurrent Neural Networks And Longitudinal Electronic Health Record Data, Seunghwan Kim

McKelvey School of Engineering Graduate Student Theses & Dissertations

Electronic Health Records (EHR) are widely adopted and used throughout healthcare systems and are able to collect and store longitudinal information data that can be used to describe patient phenotypes. From the underlying data structures used in the EHR, discrete data can be extracted and analyzed to improve patient care and outcomes via tasks such as risk stratification and prospective disease management. Temporality in EHR is innately present given the nature of these data, however, and traditional classification models are limited in this context by the cross-sectional nature of training and prediction processes. Finding temporal patterns in EHR is especially …

Review Of Adjunctive Midodrine To Facilitate Weaning Intravenous Vasopressors In Critically Ill Patients, Claudia Martin Diaz, Heidi Clarke, Payal Patel, Radhan Gopalani, Stephanie Palma

All Publications

Background/Purpose: Intravenous (IV) vasopressor agents are mainstay therapy for the management of refractory hypotension in critically ill patients in the intensive care unit (ICU). Patients remain in the ICU for vasopressor administration and monitoring which results in increased length of stay (LOS). Midodrine is an oral alpha-1 adrenergic agonist that causes vasoconstriction and increased blood pressure. It is commonly utilized off-label as an adjunctive therapy to help wean off vasopressors and decrease ICU LOS. Although midodrine offers many benefits, a study by Rizvi, et al stated that inappropriate continuation at hospital discharge resulted in a 1.6-fold higher risk of 1-year …

Evaluation Of Clinical Outcomes Of 4-Factor Prothrombin Complex Concentrate Versus Andexanet Alfa In The Treatment Of Intracerebral Hemorrhage, Eduardo Guizan Corrales, Radhan Gopalani, Heidi Clarke, Jonatha Kline, Felipe De Los Rios La Rosa, Thomas Wolfel

All Publications

Purpose: Oral anticoagulants account for up to 20% of intracerebral hemorrhages (ICH) with one-year mortality estimated as high as 54%. Several studies have examined the use of 4-Factor prothrombin complex concentrate (4F-PCC) and andexanet alfa in the treatment of factor Xa associated ICH. High cost burden, lack of clinical outcomes, and risk of thromboembolic events continues to be a major dilemma behind product selection at many healthcare systems. The purpose of this project is to compare clinical outcomes between 4F-PCC and andexanet alfa in the management of patients with ICH secondary to apixaban and rivaroxaban at Baptist Hospital of Miami …

Expression Of Her-2/Neu In Oral Squamous Cell Carcinoma, Sana Mirza, Naila Hadi, Shahid Pervez, Sultan Zeb Khan, Sameer A. Mokeem, Tariq Abduljabbar, Nawwaf Al-Hamoudi, Fahim Vohra

Department of Pathology and Laboratory Medicine

Background: HER-2/neu is a member of the human epidermal growth factor (HER) family of transmembrane tyrosine kinases, which is significantly associated with the pathogenesis of various cancer types. The aim was to evaluate the expression of HER-2/neu in oral squamous cell carcinoma (OSCC) as a potential biomarker to target antigens for specific immunotherapy in OSCC.
Methods: One hundred and forty histologically diagnosed OSCC cases were identified. Four to five-micrometer thick formalin-fixed, paraffin-embedded tumor sections were stained with Haematoxylin and Eosin (H and E). Histological grade was assessed according to WHO/Broders classification, while tumors were staged according to the American Joint …

Pregnane Steroidogenesis Is Altered By Hiv-1 Tat And Morphine: Physiological Allopregnanolone Is Protective Against Neurotoxic And Psychomotor Effects, Jason Paris, Philippe Lière, Sarah Kim, Fakhri Mahdi, Meagen E. Buchanan, Sara R. Nass, Alaa N. Qrareya, Mohammed F. Salahuddin, Antoine Pianos, Neïké Fernandez, Zia Shariat-Madar, Pamela E. Knapp, Michaël Schumacher, Kurt F. Hauser

Faculty and Student Publications

Pregnane steroids, particularly allopregnanolone (AlloP), are neuroprotective in response to central insult. While unexplored in vivo, AlloP may confer protection against the neurological dysfunction associated with human immunodeficiency virus type 1 (HIV-1). The HIV-1 regulatory protein, trans-activator of transcription (Tat), is neurotoxic and its expression in mice increases anxiety-like behavior; an effect that can be ameliorated by progesterone, but not when 5α-reduction is blocked. Given that Tat's neurotoxic effects involve mitochondrial dysfunction and can be worsened with opioid exposure, we hypothesized that Tat and/or combined morphine would perturb steroidogenesis in mice, promoting neuronal death, and that exogenous AlloP would …

Predicting Disease Progression Using Deep Recurrent Neural Networks And Longitudinal Electronic Health Record Data, Seunghwan Kim

McKelvey School of Engineering Graduate Student Theses & Dissertations

Electronic Health Records (EHR) are widely adopted and used throughout healthcare systems and are able to collect and store longitudinal information data that can be used to describe patient phenotypes. From the underlying data structures used in the EHR, discrete data can be extracted and analyzed to improve patient care and outcomes via tasks such as risk stratification and prospective disease management. Temporality in EHR is innately present given the nature of these data, however, and traditional classification models are limited in this context by the cross- sectional nature of training and prediction processes. Finding temporal patterns in EHR is …

Cortisol As An Acute Stress Biomarker In Young Hematopoietic Cell Transplant Patients/Caregivers: Active Music Engagement Protocol., Kristen A. Russ, Steven J. Holochwost, Susan M. Perkins, Kristin Stegenga, Seethal A. Jacob, David Delgado, Amanda K. Henley, Joan E. Haase, Sheri L. Robb

Manuscripts, Articles, Book Chapters and Other Papers

Objective: Primary aims of the proposed protocol are to determine the feasibility/acceptability of the active music engagement intervention protocol during hematopoietic stem cell transplantation (HSCT) and clinical feasibility/acceptability of the biological sample collection schedule.

Design: The authors propose a single-case, alternating treatment design to compare levels of child and caregiver cortisol in blood and saliva collected on alternating days, when the dyad receives and does not receive AME sessions. Included are the scientific rationale for this design and detailed intervention and sample collection schedules based on transplant type.

Setting/Location: Pediatric inpatient HSCT unit.

Subjects: Eligible participants are dyads of children …

Alternative Splicing Of The Slco1b1 Gene: An Exploratory Analysis Of Isoform Diversity In Pediatric Liver., Bianca D. Van Groen, Chengpeng Bi, Roger Gaedigk, Vincent S. Staggs, Dick Tibboel, Saskia N. De Wildt, J Steven Leeder

Manuscripts, Articles, Book Chapters and Other Papers

The hepatic influx transporter OATP1B1 (SLCO1B1) plays an important role in the disposition of endogenous substrates and drugs prescribed to children. Alternative splicing increases the diversity of protein products from > 90% of human genes and may be triggered by developmental signals. As concentrations of several endogenous OATP1B1 substrates change during growth and development, with this exploratory study we investigated age-dependent alternative splicing of SLCO1B1 mRNA in 97 postmortem livers (fetus-adolescents). Twenty-seven splice variants were detected; 10 were confirmed by additional bioinformatic analyses and verified by quantitative polymerase chain reaction, and selected for detailed analysis based on relative abundance, association with …

Deprivation Matters: Understanding Associations Between Neighbourhood Deprivation, Unhealthy Food Outlets, Unhealthy Dietary Behaviours And Child Body Size Using Structural Equation Modelling., Victoria Egli, Matthew Hobbs, Jordan A. Carlson, Niamh Donnellan, Lisa Mackay, Daniel Exeter, Karen Villanueva, Caryn Zinn, Melody Smith

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Children residing in neighbourhoods of high deprivation are more likely to have poorer health, including excess body size. While the availability of unhealthy food outlets are increasingly considered important for excess child body size, less is known about how neighbourhood deprivation, unhealthy food outlets and unhealthy dietary behaviours are interlinked.

METHODS: This study involves children aged 8-13 years (n=1029) and resided in Auckland, New Zealand. Unhealthy dietary behaviours (frequency of consumption of unhealthy snacks and drinks) and food purchasing behaviour on the route to and from school were self-reported. Height and waist circumference were measured to calculate waist-to-height ratio …

Management Of Atrial Fibrillation With Smartphone Technology, Teresa Praus

UNLV Theses, Dissertations, Professional Papers, and Capstones

Atrial fibrillation is the most common arrhythmia affecting over six million people; it is predicted to increase two-fold by the year 2050. This arrhythmia results in a lack of

atrial/ventricular communication, accompanied by ineffective atrial contraction, suboptimal ventricular filling, and thrombus formation. This may lead to stroke, and ultimately heart failure. The current economic burden related to the complications of atrial fibrillation is estimated to be greater than $6 billion annually with potentially catastrophic events, further increasing expenditure.

When patients experience symptoms related to atrial fibrillation, it is common for them to present to a hospital emergency department. These visits, …

The Use Of Female Permanent Contraception Among Women Desiring To Limit Childbearing In Sub-Saharan Africa: Analyses Of The Spatial Pattern And Individual- And Country-Level Determinants, Babayemi Oluwaseun Olakunde

UNLV Theses, Dissertations, Professional Papers, and Capstones

Female permanent contraception (FPC) is the most commonly used contraceptive method, globally. It is a convenient, safe, and cost-effective modern contraceptive method that permanently stops childbearing among women. Despite its benefits, previous reports suggest that the increasing proportion of women who desire to limit childbearing in sub-Saharan Africa (SSA) rely more on less effective contraceptive methods, predisposing them to unintended pregnancies and their associated consequences. This study aimed to add to the sparse body of evidence on the use of FPC and the associated determinants among women with demand for limiting childbearing in SSA. Using data from Demographic and Health …

Rapid Evolution Of Starvation Resistance In Drosophila: Physiological And Molecular Mechanisms, Austin Joseph Mckenna

UNLV Theses, Dissertations, Professional Papers, and Capstones

The Gibbs lab has maintained starvation-selected Drosophila melanogaster for >130 generations. These starvation-selected flies evolved an obese phenotype with a suite of physiological differences compared to control-fed flies. Previous studies have shown that long-term starvation-selected Drosophila contain more lipids, have lower metabolic rates and develop more slowly than controls. This dissertation encompasses 1) Examining the molecular mechanisms contributing to starvation resistance, 2) Functional validation of the candidate plin1 allele, and 3) Rapid physiological and genomic evolution in starvation-selected Drosophila.

Starvation-selected Drosophila survive starvation conditions much longer than control-fed flies. This study took a simple approach to identify possible differences in …

Comparison Of Digital Treatment Setups And Final Treatment Outcomes Of Class Ii Division 1 Malocclusions Treated With Premolar Extractions, Sogol Shantiyai

UNLV Theses, Dissertations, Professional Papers, and Capstones

Objective: This study aimed to determine whether there are differences between pre-orthodontic treatment dimensions when compared to the virtual treatment simulations and actual orthodontic treatment outcomes in Class II malocclusions treated with two or four premolar extractions.

Introduction: The use of intraoral scanners has become commonplace in orthodontic practices, giving practitioners the ability to scan and assess maxillary and mandibular dental morphology and occlusal relationships chairside and in real-time. Practitioners can use virtual treatment planning to evaluate different extraction patterns, visualize potential non-extraction outcomes using interproximal reduction, and alter anchorage strategies based on the amount of retraction or protraction required …

Hdr Brachytherapy For Skin Cancer Using H.A.M. Applicator, Timothy Richard Thatcher

UNLV Theses, Dissertations, Professional Papers, and Capstones

Skin cancer is the most common type of malignancy affecting both men and women in the United States. A majority of these cases are nonmelanoma skin cancers (NMSC) such as basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The goal of any skin cancer treatment is to cure the lesion itself while also preserving function and optimizing superficial cosmesis. High dose rate (HDR) brachytherapy provides an alternative to superficial x-ray or electron beam for skin cancer treatment. Utilizing an Iridium 192 source soldered to the end of a wire, surface dose can be administered at predetermined positions with sharper …

A Comparison Of Lateral Cephalometric And Arch Dimension Changes In Patients With Class Ii Malocclusions Treated With 2-Premolar And 4-Premolar Extraction Patterns, Melissa Marie Ven Dange

UNLV Theses, Dissertations, Professional Papers, and Capstones

The aim of this study is to gather and analyze data representing detailed changes in model and cephalometric variables that will support clinicians in the premolar extraction decision- making process during camouflage treatment of class II dental patients. It is expected that the models, as measured by intra-arch dimensions, overjet, overbite, and mandibular crowding, and cephalometric radiographs, evaluated by their anteroposterior skeletal discrepancy, incisor inclinations, dental and skeletal vertical positions, and soft tissue characteristics, will significantly differ from within the same treatment group, pre-treatment to post-treatment, and between treatment groups. This retrospective study evaluated the model and cephalometric changes in …

Stress And Coping In Food-Insecure African Americans In Clark County, Nevada, Johanna Andrews

UNLV Theses, Dissertations, Professional Papers, and Capstones

African Americans have the highest rates of food insecurity than any other racial/ethnic group in the nation as a result of poverty, low household income, unemployment, food injustice, food mirages, and racial segregation. This consistent uncertainty in food access demonstrably results in poor mental health outcomes for food-insecure African Americans. Thus, the Transactional Model of Stress and Coping provides a theoretical framework to investigate how African Americans cope with food insecurity. The purpose of this study was to evaluate processes of coping with food insecurity and determine their impact on emotional well-being for African Americans in Clark County, Nevada. A …

The Relationship Between Tree Canopy And Social Capital On Physical Activity In Unlv Students, Melissa Bartshe

UNLV Theses, Dissertations, Professional Papers, and Capstones

Despite the numerous health benefits, rates of physical activity are low, especially among the college student population. Neighborhood tree canopy is one aspect of the built environment that has been shown to positively impact physical activity. Social capital has also been correlated with higher rates of physical activity. The sprawling urban design and arid desert climate of Las Vegas pose unique challenges to both tree canopy and social capital. Additionally, the relationship between tree canopy, social capital, and physical activity is understudied in the college student population. The purpose of this study was to assess the relationship of tree canopy …

Assessing The Health And Financial Burden Of Neonatal Abstinence Syndrome Among All Payer Inpatient Pediatric Discharges In Nevada, Kavita Batra

UNLV Theses, Dissertations, Professional Papers, and Capstones

Neonatal abstinence syndrome (NAS) is a postnatal withdrawal syndrome among neonates born to drug-dependent mothers. NAS poses a significant health and fiscal challenge nationally, with its incidence increasing by a factor of six (1.20 to 6.7 per 1,000 hospital births/year) along with the concomitant rise in health care cost from 2000-2016. Besides national data, it is critical to quantify NAS at the state-level to identify the target areas for prevention. Given the higher opioid prescribing rates among pregnant women in Nevada, it is critical to assess the health and financial magnitude of NAS in the state. The objectives of this …