Medicine and Health Sciences Commons^™

Different States, Common Issues: Moving Mountains One Service At A Time., Suzzanne Freeze, Allison Hall, Stacy Collins, Duane Shumate, Cindy Thomas, Barbara Brent, Thinkwork! At The Institute For Community Inclusion At Umass Boston

ThinkWork! Publications

No abstract provided.

Guidepost 1: Individualize Supports For Each Person, Hannah Curren, Oliver Lyons, Jaimie Ciulla Timmons, Thinkwork! At The Institute For Community Inclusion At Umass Boston

ThinkWork! Publications

Community Life Engagement refers to how people with intellectual and developmental disabilities (IDD) access and participate in their communities outside of employment as part of a meaningful day. (See “What Is Community Life Engagement?” in the box on page 3.) The Community Life Engagement team has been conducting research to identify the elements of high-quality Community Life Engagement (CLE) supports. We have created a series of four Engage Briefs to examine the guideposts in detail.

Epidemiology And Impact Of Abdominal Oblique Injuries In Major And Minor League Baseball., Christopher L Camp, Stan Conte, Steven B. Cohen, Matthew Thompson, John D' Angelo, Joseph T Nguyen, Joshua S Dines

Rothman Institute Papers

BACKGROUND: Oblique injuries are known to be a common cause of time out of play for professional baseball players, and prior work has suggested that injury rates may be on the rise in Major League Baseball (MLB).

PURPOSE: To better understand the current incidence of oblique injuries, determine their impact based on time out of play, and to identify common injury patterns that may guide future injury prevention programs.

STUDY DESIGN: Descriptive epidemiological study.

METHODS: Using the MLB Health and Injury Tracking System, all oblique injuries that resulted in time out of play in MLB and Minor League Baseball (MiLB) …

Combined Chondroitinase And Klf7 Expression Reduce Net Retraction Of Sensory And Cst Axons From Sites Of Spinal Injury, Zimei Wang, Kristen N. Winsor, Evan Hess, Murray G. Blackmore, Christopher Nienhaus

Biomedical Sciences Faculty Research and Publications

Axon regeneration in the central nervous system is limited both by inhibitory extracellular cues and by an intrinsically low capacity for axon growth in some CNS populations. Chondroitin sulfate proteoglycans (CSPGs) are well-studied inhibitors of axon growth in the CNS, and degradation of CSPGs by chondroitinase has been shown to improve the extension of injured axons. Alternatively, axon growth can be improved by targeting the neuron-intrinsic growth capacity through forced expression of regeneration-associated transcription factors. For example, a transcriptionally active chimera of Krüppel-like Factor 7 (KLF7) and a VP16 domain improves axon growth when expressed in corticospinal tract neurons. Here …

An Over-The-Counter Treatment For Diarrhea Leading To Euphoria And Fatal Arrhythmia., Angela Magdaleno, Michael Sumner Do, Travis Magdaleno Md, Justin L. Guthier Do, Apurva Vyas Md

Department of Medicine

No abstract provided.

Epigenomic Reprogramming In Inorganic Arsenic-Mediated Gene Expression Patterns During Carcinogenesis, Meredith Eckstein, Rebekah Eleazer, Matthew Rea, Yvonne N. Fondufe-Mittendorf

Molecular and Cellular Biochemistry Faculty Publications

Arsenic is a ubiquitous metalloid that is not mutagenic but is carcinogenic. The mechanism(s) by which arsenic causes cancer remain unknown. To date, several mechanisms have been proposed, including the arsenic-induced generation of reactive oxygen species (ROS). However, it is also becoming evident that inorganic arsenic (iAs) may exert its carcinogenic effects by changing the epigenome, and thereby modifying chromatin structure and dynamics. These epigenetic changes alter the accessibility of gene regulatory factors to DNA, resulting in specific changes in gene expression both at the levels of transcription initiation and gene splicing. In this review, we discuss recent literature reports …

Management Of Giant Retinal Tear Detachments, Maria H. Berrocal, Megan Chenworth, Luis A. Acaba

Student Papers, Posters & Projects

Giant retinal tears (GRTs) are full-thickness circumferential tears of more than 90 degrees of the retina that are associated with vitreous detachment. They are related to ocular trauma, high myopia, aphakia, pseudophakia, genetic mutations involving collagen and young age. GRTs comprise 1.5% of all rhegmatogenous retinal detachments and the average age of incidence is 42 years. GRTs are more common in males, as 72% of all cases occur in males. The incidence of GRTs in the general population is estimated to be 0.05 per 100,000 individuals. Common techniques used in the management of GRTs include fluid-air exchange, pneumatic retinopexy, scleral …

The Role Of Hyalomma Truncatum On The Dynamics Of Rift Valley Fever: Insights From A Mathematical Epidemic Model, Sansao A. Pedro, Shirley Abelman, Henri E.Z. Tonnang

All Peer-Reviewed Publications

To date, our knowledge of Rift Valley fever (RVF) disease spread and maintenance is still limited, as flooding, humid weather and presence of biting insects such as mosquitoes, have not completely explained RVF outbreaks. We propose a model that includes livestock, mosquitoes and ticks compartments structured according to their questing and feeding behaviour in order to study the possible role of ticks on the dynamics of RVF. To quantify disease transmission at the initial stage of the epidemic, we derive an explicit formula of the basic reproductive number, R0. Using the concept of Metzler matrix, we state necessary conditions for …

Risk Factors For Chronic Diseases And Multimorbidity In A Primary Care Context Of Central Argentina: A Web-Based Interactive And Cross-Sectional Study, David E.V. Olivares, Frank R.V. Chambi, Evelyn M.M. Chañi, Winston J. Craig, Sandaly O.S. Pacheco, Fabio J. Pacheco

Faculty Publications

© 2017 by the authors. Licensee MDPI, Basel, Switzerland. Global health agencies estimate an increase of chronic diseases in South America. Nevertheless, few studies have investigated chronic diseases and their risk factors in the perspective of multimorbidity. This research aimed to identify these aspects in a primary health care setting of central Argentina. The Pan America version of the STEP wise approach surveillance (STEPS) instrument of the World Health Organization was applied to 1044 participants, 365 men and 679 women, with a mean age of 43 years. High prevalence of overweight (33.5%), obesity (35.2%), central obesity (54%), dyslipidemia (43.5%), metabolic …

Integrating Feminist Theory Into Myocardial Infarction Symptom Research, John R. Blakeman

Faculty Publications - Mennonite College of Nursing

Heart disease remains the number one killer of men and women globally, yet women have traditionally received less research attention in the cardiovascular literature, and an androcentric bias has persisted. Specifically, symptoms of myocardial infarction (MI) have been shown to be varied between men and women. Feminist standpoint theory is one perspective that researchers can use to explore the situated knowledge that women possess, given their unique experiences. This project incorporates a substantial body of literature, reviews feminist standpoint theory, and proposes three critical steps for MI symptom researchers to use as guides when conducting research. To advance the perspectives …

Proposed New York State Health Regulation Contains Troubling Exemption: The Public Rights/Private Conscience Project Responds To A Proposal On Abortion Access, Public Rights/Private Conscience Project

Center for Gender & Sexuality Law

A proposed New York State regulation requiring insurance plans to cover “medically necessary” abortions contains a broad religious exemption that would undermine the state’s longstanding commitment to reproductive health. The exemption — which is not required by New York’s Constitution or laws — defines the term “religious employers” to include large nonprofits and even some for-profit companies. In the face of a national movement to enact anti-LGBTQ and anti-choice religious exemptions, the regulation would set a harmful precedent by accommodating religion at the expense of other fundamental liberty and equality rights.

Inability To Perform At An Acceptable Level, Michael G. Maihofer Dds

The Journal of the Michigan Dental Association

Regular column featuring ethical guidance and consideration for practicing dentists.

Efficacy And Tolerability Of Adjunctive Brivaracetam In Patients With Prior Antiepileptic Drug Exposure: A Post-Hoc Study., Ali A. Asadi-Pooya, Michael R. Sperling, Steve Chung, Pavel Klein, Anyzeila Diaz, Sami Elmoufti, Jimmy Schiemann, John Whitesides

Department of Neurology Faculty Papers

Brivaracetam (BRV), a selective, high-affinity ligand for synaptic vesicle protein 2A, is a new antiepileptic drug (AED) for adjunctive treatment of focal (partial-onset) seizures in adults with epilepsy. This post-hoc analysis was conducted to explore the efficacy of adjunctive BRV in patients with prior levetiracetam (LEV) exposure and whether changes in efficacy were related to the similar mechanism of action of these two drugs. Data were pooled from three Phase III studies (NCT00490035; NCT00464269; NCT01261325) of adults with focal seizures taking 1-2 AEDs who received placebo or BRV 50-200mg/day without titration over a 12-week treatment period. Patients taking concomitant LEV …

Open-Label Phase I Clinical Study To Assess The Safety And Efficacy Of Cilostazol In Patients Undergoing Internal Carotid Artery Stent Placement, A E. Hassan, H Zacharatos, M Grigoryan, Muhammed Suri, Adnan Qureshi

Articles

BACKGROUND:

One-month dual antiplatelet treatment, with aspirin and clopidogrel, following internal carotid artery stent placement is the current standard of care to prevent in-stent thrombosis. Cilostazol, an antiplatelet drug, has been demonstrated to have a safety profile comparable to aspirin and clopidogrel.

OBJECTIVE:

To evaluate the safety and clinical efficacy of cilostazol and aspirin therapy following internal carotid artery stent placement up to 1 month postprocedure.

METHODS:

A phase I open-label, nonrandomized two-center prospective study was conducted. All subjects received aspirin (325 mg/day) and cilostazol (200 mg/day) 3 days before extracranial stent placement. Two antiplatelet agents were continued for 1 …

Habituation Of Distress And Craving During Treatment As Predictors Of Change In Ptsd Symptoms And Substance Use Severity, Christal L. Badour, Julianne C. Flanagan, Daniel F. Gros, Therese Killeen, Irene Pericot-Valverde, Kristina J. Korte, Nicholas P. Allan, Sudie E. Back

Psychology Faculty Publications

Objective—Increasing evidence supports the efficacy of trauma-focused exposure therapy in the treatment of posttraumatic stress disorder (PTSD) and co-occurring substance use disorders. Little is known, however, about the mechanisms of change in treatment for patients with PTSD and co-occurring substance use disorders. The aim of the present study was to examine whether within- and between-session habituation of distress and substance craving during imaginal exposure relates to treatment outcomes among U.S. military veterans with PTSD and a co-occurring substance use disorder (N = 54).

Method—Veterans received Concurrent Treatment of PTSD and Substance Use Disorders Using Prolonged Exposure, a manualized …

Relb Expression Determines The Differential Effects Of Ascorbic Acid In Normal And Cancer Cells, Xiaowei Wei, Yong Xu, Fang Fang Xu, Luksana Chaiswing, David M. Schnell, Teresa Noel, Chi Wang, Jinfei Chen, Daret K. St. Clair, William H. St. Clair

Toxicology and Cancer Biology Faculty Publications

Cancer cells typically experience higher oxidative stress than normal cells, such that elevating pro-oxidant levels can trigger cancer cell death. Although pre-exposure to mild oxidative agents will sensitize cancer cells to radiation, this pre-exposure may also activate the adaptive stress defense system in normal cells. Ascorbic acid is a prototype redox modulator that when infused intravenously appears to kill cancers without injury to normal tissues; however, the mechanisms involved remain elusive. In this study, we show how ascorbic acid kills cancer cells and sensitizes prostate cancer to radiation therapy while also conferring protection upon normal prostate epithelial cells against radiation-induced …

Technical Considerations In Revision Anterior Cruciate Ligament Reconstruction For Operative Techniques In Orthopaedics, Jeremy M. Burnham, Elmar Herbst, Thierry Pauyo, Thomas Pfeiffer, Darren L. Johnson, Freddie H. Fu, Volker Musahl

Orthopaedic Surgery and Sports Medicine Faculty Publications

As the incidence of anterior cruciate ligament (ACL) reconstruction continues to increase, the rate of revision surgery continues to climb. Revision surgery has inherent challenges that must be addressed to achieve successful results. The cause of the primary ACL reconstruction failure should be determined and careful preoperative planning should be performed to address the cause(s) of failure. Each patient undergoing revision surgery should undergo a thorough history and physical examination, receive full-length alignment radiographs, lateral radiographs, 45° flexion weight-bearing posteroanterior radiographs, and patellofemoral radiographs. The 3-dimensional computed tomography scan should be performed to assess tunnel position and widening. Magnetic resonance …

Community To Clinic Navigation To Improve Diabetes Outcomes, Nancy E. Schoenberg, Gabriele Ciciurkaite, Mary Kate Greenwood

Behavioral Science Faculty Publications

Rural residents experience rates of Type 2 Diabetes Mellitus (T2DM) that are considerably higher than their urban or suburban counterparts. Two primary modifiable factors, self-management and formal clinical management, have potential to greatly improve diabetes outcomes. “Community to Clinic Navigation to Improve Diabetes Outcomes,” is the first known randomized clinical trial pilot study to test a hybrid model of diabetes self-management education plus clinical navigation among rural residents with T2DM. Forty-one adults with T2DM were recruited from two federally qualified health centers in rural Appalachia from November 2014–January 2015. Community health workers provided navigation, including helping participants understand and implement …

Oral Cannabidiol Does Not Produce A Signal For Abuse Liability In Frequent Marijuana Smokers, Shanna Babalonis, Margaret Haney, Robert J. Malcolm, Michelle R. Lofwall, Victoria R. Votaw, Steven Sparenborg, Sharon L. Walsh

Behavioral Science Faculty Publications

Background—Cannabidiol (CBD) is a naturally occurring constituent of the marijuana plant. In the past few years, there has been great interest in the therapeutic effects of isolated CBD and it is currently being explored for numerous disease conditions (e.g., pain, epilepsy, cancer, various drug dependencies). However, CBD remains a Schedule I drug on the U.S. Controlled Substances Act (CSA). Despite its status, there are no well-controlled data available regarding its abuse liability.

Methods—Healthy, frequent marijuana users (n=31) were enrolled in this within subject, randomized, placebo-controlled, double-blind, multisite study that administered oral cannabidiol (0, 200, 400, 800 …

Reduction Of Cocaine-Induced Locomotor Effects By Enriched Environment Is Associated With Cell-Specific Accumulation Of Δfosb In Striatal And Cortical Subregions, Audrey Lafragette, Michael T. Bardo, Virginie Lardeux, Marcello Solinas, Nathalie Thiriet

Psychology Faculty Publications

Background: Early exposure to enriched environments has been shown to decrease the locomotor effects induced by repeated injections of cocaine and modify basal and cocaine-induced total protein levels of the transcription factor ΔFosB in the whole striatum of mice. In this study, we aimed at characterizing whether the profile of ΔFosB accumulation induced by enriched environments and cocaine would be similar or different in terms of brain areas and cell type.

Methods: We used mice expressing the eGFP protein in D1 receptor positive (D1R(+)) neurons to determine whether ΔFosB induced by enriched environment or cocaine injections (5×15 mg/kg) would occur …

Faster Self-Paced Rate Of Drinking For Alcohol Mixed With Energy Drinks Versus Alcohol Alone, Cecile A. Marczinski, Mark T. Fillmore, Sarah F. Maloney, Amy L. Stamates

Psychology Faculty Publications

The consumption of alcohol mixed with energy drinks (AmED) has been associated with higher rates of binge drinking and impaired driving when compared with alcohol alone. However, it remains unclear why the risks of use of AmED are heightened compared with alcohol alone even when the doses of alcohol consumed are similar. Therefore, the purpose of this laboratory study was to investigate if the rate of self-paced beverage consumption was faster for a dose of AmED versus alcohol alone using a double-blind, within-subjects, placebo-controlled study design. Participants (n = 16) of equal gender who were social drinkers attended 4 separate …

Curbing The Dui Offender's Self-Efficacy To Drink And Drive: A Laboratory Study, Walter Roberts, Mark T. Fillmore

Psychology Faculty Publications

Background—People arrested for driving under the influence of alcohol (DUI) are at high risk to reoffend. One reason for this high rate of recidivism among DUI offenders is that these individuals systematically underestimate the degree to which alcohol impairs their ability to drive. This study compared perceived and objective driving ability following alcohol and performance feedback in drivers with and without a history of DUI.

Method—Adult drivers with (n = 20) and without (n = 20) a history of DUI arrest attended two dose challenge sessions where they received 0.64 g/kg alcohol or placebo, completed a simulated driving …

Effect Of Cigarette Smoke Exposure And Mutant Kras Overexpression On Pancreatic Cell Proliferation, Howard P. Glauert, R. Scott Elliott, Sung Gu Han, Mark Athey, Eun Young Lee, C. Gary Gairola

Pharmacology and Nutritional Sciences Faculty Publications

Pancreatic cancer is the fourth leading cause of cancer‑associated mortality. The major risk factor for pancreatic cancer is cigarette smoking. Kras mutations are commonly observed in human pancreatic cancers. The present study examined the hypothesis that exposure to cigarette smoke and overexpression of a mutant Kras gene in the pancreas affects pancreatic cell proliferation in mice. Mice overexpressing the mutant Kras gene (KRas^G12D) in the pancreas as well as wild‑type mice were exposed to environmental tobacco smoke for 2 weeks. Overexpression of mutant Kras increased cell proliferation in pancreatic ductal, acinar and islet cells. Notably, cigarette smoke exposure …

Developmental Origins Of Cardiovascular Disease: Impact Of Early Life Stress In Humans And Rodents, Margaret O. Murphy, Dianne M. Cohn, Analia S. Loria

Pharmacology and Nutritional Sciences Faculty Publications

The Developmental Origins of Health and Disease (DOHaD) hypothesizes that environmental insults during childhood programs the individual to develop chronic disease in adulthood. Emerging epidemiological data strongly supports that early life stress (ELS) given by the exposure to adverse childhood experiences is regarded as an independent risk factor capable of predicting future risk of cardiovascular disease. Experimental animal models utilizing chronic behavioral stress during postnatal life, specifically maternal separation (MatSep) provides a suitable tool to elucidate molecular mechanisms by which ELS increases the risk to develop cardiovascular disease, including hypertension. The purpose of this review is to highlight current epidemiological …

Promoting Teen Contraceptive Use By Intervention With Their Mothers, Richard A. Crosby, Tom Collins, Lindsay R. Stradtman

Health, Behavior & Society Faculty Publications

Introduction: The purpose of this pilot study was to test a community outreach model designed to help mothers in a rural, medically underserved area navigate their teen daughters to health department services for long-acting reversible contraception (LARC) or alternative contraception.

Methods: The pilot study used a single-group, post-test only design. Mothers of teen daughters (N=142) received a 1-hour, one-to-one intervention session (in outreach settings) from Community Liaisons. Mothers received training on how to communicate with their daughters about LARC and other contraceptive methods. Data were collected from June through October 2014, and analyzed in September 2015.

Results: The authors re-contacted …

บทบาทของเวชศาสตร์ฟื้นฟู ในสังคมผู้สูงอายุ, กฤษณา พิรเวช

Chulalongkorn Medical Journal

ประเทศไทยกำหนดนิยาม “ผู้สูงอายุ” ไว้ในพระราชบัญญัติผู้สูงอายุพ.ศ. 2546 มาตรา 3 “ผู้สูงอายุ” หมายความว่า บุคคลซึ่งมีอายุเกิน หกสิบปีบริบูรณ์ขึ้นไป และมีสัญชาติไทย แต่ในประเทศที่พัฒนาแล้วส่วนใหญ่ใช้อายุ 65 ปีขึ้นไป การแบ่งช่วงอายุของผู้สูงวัยสามารถแบ่งออกได้เป็น 3 ช่วง คือ วัยต้น (อายุ 60 - 69 ปี) วัยกลาง (อายุ 70 - 79 ปี) และวัยปลาย (อายุ 80 ปีขึ้นไป) ผลการสำรวจข้อมูลประชากรสูงวัยในประเทศไทยของสำนักงานสถิติแห่งชาติในปีพ.ศ. 2557 พบว่า ประเทศไทยมีผู้สูงวัยจำนวนร้อยละ 14.9 ซึ่งเพิ่มขึ้นมากกว่าปีพ.ศ. 2537 ถึง 2 เท่า โดยสามารถจำแนกผู้สูงวัยเป็นวัยต้น ร้อยละ 56.5 วัยกลางร้อยละ 29.9 และวัยปลาย ร้อยละ 13.6 ประเทศไทยกำลังจะกลายเป็น “สังคมสูงวัยอย่างสมบูรณ์” ในปีพ.ศ. 2564 หรือในอีกเพียง 4 ปีข้างหน้าเมื่อประชากรอายุ 60 ปีขึ้นไปมีมากถึงร้อยละ 20 และคาดว่าจะเป็น “สังคมสูงวัยระดับสุดยอด” ในอีกไม่ถึง 20 ปีข้างหน้านี้เมื่อประชากรอายุ 60 ปีขึ้นไปมีสัดส่วนถึงร้อยละ 28 ของประชากรทั้งหมด.

Neutral Wrist Splint For Mild To Moderate Carpal Tunnel Syndrome, Jariya Boonhong, Sirikwan Panyasriwanit

Chulalongkorn Medical Journal

Background : Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy. Neutral wrist splint has been recommended for mild to moderate symptoms CTS. There is insufficient evidence regarding the effectiveness of splinting in longer periods of time (at least 3 months).Objective : To evaluate the effects of 3 months neutral wrist splint on neurophysiologic condition, symptoms and functions for mild to moderate carpal tunnel syndrome (CTS).Methods : Fifty-four patients with clinical symptoms, nerve conduction study (NCS), and diagnosed as mild to moderate CTS. During the 3-month duration of the study, the treatment group received day and night time, neutral …

Effects Of Mirror Therapy In Recovering Strength And Function Of The Upper Limbs In Chronic Stroke Patients: A Randomized Controlled Trial, Jirapa Champaiboon, Rames Rueangyu, Vonphadet Sontim, Krisna Piravej

Chulalongkorn Medical Journal

Background : Stroke is one of the biggest healthcare problems in developing countries.Majority of the stroke patients have persistent upper limbs motorimpairment. One of the promising methods to assist motor improvementis mirror therapy. However, the evidence supporting efficacy of thisintervention in chronic stroke patients is limited, due to small samplesize and non-RCTs in most currently available studies.Objective : To investigate whether mirror therapy, as an adjunct program, can helpchronic stroke survivors regain their upper limbs’ motor functions, handrelatedfunctions and reduce spasticity.Methods : Forty-four chronic stroke patients were divided into 2 groups, whounderwent clinical assessment for adjunct mirror therapy versus placebo.Clinical …

Comparison Between Effects Of Radial Extracorporeal Shock Wave Therapy And Progressive Resistive Exercise In Treatments Of Chronic Lateral Elbow Tendinosis, Worawan Soonsuwan, Sarissa Rangkla

Chulalongkorn Medical Journal

Background : Elbow tendinosis is the most common cause of elbow pain. Both radial extracorporeal shock wave therapy (rESWT) and progressive resistive exercise (PRE) are widely used and share evidences of effectiveness intreating elbow tendinosis. So far, there have not been any evidence that confirms better effectiveness of one treatment over the other.Objective : To compare the effects between rESWT and PRE in chronic lateral elbow tendinosis regarding the improvement of pain, The Disabilities of the Arm, Shoulder and Hand (DASH) score, pressure pain threshold and pain-free handgrip strength.Methods : Eighteen chronic lateral elbow tendinosis patients that had failed other …

ความไวและความจำเพาะของการทดสอบโดยยกมือเหนือศีรษะในโรคเส้นประสาทมีเดียนถูกกดรัดบริเวณอุโมงค์ข้อมือ, กุลยา เศรษฐมงคล, สิริขวัญ ปัญญาศรีวณิช

Chulalongkorn Medical Journal

ปัญหา : การตรวจ hand elevation test นำมาใช้ในการวินิจฉัยโรคเส้นประสาทมีเดียนถูกกดรัดบริเวณอุโมงค์ข้อมือ (carpal tunnel syndrome, CTS) ได้ดีหรือไม่วัตถุประสงค์ : เพื่อศึกษาความไวและความจำเพาะของการตรวจ hand elevation test ในการวินิจฉัยโรค CTS และเปรียบเทียบกับการตรวจอื่นวิธีการศึกษา : ผู้ป่วยที่มีอาการเข้าได้กับโรค CTS มารับการตรวจที่ห้องตรวจไฟฟ้าวินิจฉัยโรงพยาบาลจุฬาลงกรณ์ ผู้ป่วยที่มีอาการเข้าได้กับโรค CTS 48 ราย ได้รับการตรวจ hand elevation test, Tinel’s test, modified Phalen’s test และcarpal compression test ร่วมกับตรวจไฟฟ้าวินิจฉัยเพื่อยืนยันการวินิจฉัยโรคCTS แล้ววิเคราะห์ค่าความไว และความจำเพาะของการตรวจแต่ละประเภทผลการศึกษา hand elevation test, Tinel’s test, modified Phalen’s test และ carpalcompression test ความไว คิดเป็นร้อยละ 74, 24.7, 46.8 และ 64.9ความจำเพาะ คิดเป็นร้อยละ 52.6, 89.5, 57.9 และ 73.7 ตามลำดับ การแปลผลแบบร่วมของ hand elevation test และ carpal compression test มีความไวสูงสุด ร้อยละ 80.5สรุป : การตรวจ hand elevation test มีความไวสูงสุด เหมาะในการใช้วินิจฉัยโรคเส้นประสาทมีเดียนถูกกดรัดบริเวณอุโมงค์ข้อมือ และการแปลผลร่วมกันของ hand elevation test และ carpal compression test ความไวสูงสุด ช่วยเพิ่มความเชื่อมั่นในการวินิจฉัยได้.