Medicine and Health Sciences Commons^™

Short-Term Bilateral Adrenalectomy: Biochemical And Morphological Alterations In The Rat Hippocampus, Ahlam Said Abi Issa

Theses

Several studies showed the effects of glucocorticoid hormones on the hippocampus. It has been reported that the chronic administration of high dose glucocorticoids (GC) results in the degeneration of pyramidal neurons. However, bilateral adrenalectomy has been shown to damage the hippocampal neurons. Although the effects of long-term adrenalectomy have been studied extensively, there are few publications on the effects of short-term bilateral adrenalectomy (ADX). We aimed to investigate the effects of ADX on levels of pro-inflammatory cytokines interleukin-1β (IL-1β), interkeukin-6 (IL-6) and tumor necrosis factor-α (TNF-α); levels of growth factors, response of microglia and astrocytes to neuronal death, and oxidative …

An Exploratory Factor Analysis Examining Experiences And Perceptions Of Campus Safety For International Students, Sonia H. Ramrakhiani

Counseling & Human Services Theses & Dissertations

Although international students make up a significant percentage of the college population and contribute to higher education institutions in multiple ways, a lack of attention is paid to their safety needs. This dissertation examined the experiences and perceptions of campus safety among international college/university students in the United States. The researcher sampled participants from different institutions around the country, who self-identified as international students. A researcher-developed 53-item Likert scale questionnaire, International Students’ Safety Questionnaire (ISSQ), was administered to the sample. Findings from the exploratory factor analysis (EFA) provided evidence for the four-factor solution for the 26-item ISSQ accounting for 48.65% …

Nsu Sharks Rx-Spring, 2017, College Of Pharmacy

NSU Sharks Rx

Volume 3, Number 1

Personality, Motivation, And Internet Gaming Disorder: Understanding The Addiction, Kristy L. Carlisle

Counseling & Human Services Theses & Dissertations

This dissertation examined the relationships among personality traits, motivation for play, and Internet gaming disorder in a diverse sample of Internet gamers, using a group correlational design and path analysis. The researcher sampled participants who self-identify as Internet gamers by posting invitations to participate in the study on Internet forums, as well as by accessing the gaming population at Pokémon Go hotspots. The study used valid and reliable instruments: The Ten-Item Internet Gaming Disorder Test (IGD-10), the abbreviated form of the Big Five Inventory (BFI-10), and the Motivation to Play Online Games Questionnaire (MPOGQ). Data analysis included descriptive statistics related …

The Relationship Between Trauma Exposure And College Student Adjustment: Factors Of Resilience As A Mediator, Amber Leih Jolley

Counseling & Human Services Theses & Dissertations

Adjustment to college is an important developmental task for students entering institutions of higher education. More than half of students who enter college report exposure to a potentially traumatic event (PTE), with many students reporting multiple event exposure (Banyard & Cantor, 2004). Many students adjust well to college despite experiencing PTEs, suggesting that certain factors may mitigate the effects of exposure. This study utilized archival data to explore the relationship between the type of PTE, accumulation of PTEs, underlying factors of resilience, and adjustment to college in a national sample of treatment-seeking college students. The data were analyzed using hierarchical …

The Role Of Self-Care And Hardiness In Moderating Burnout In Mental Health Counselors, Traci Danielle Richards

Counseling & Human Services Theses & Dissertations

This study explored the relationship between self-care, hardiness, and burnout in a sample of mental health counselors using a hierarchical multiple regression. Additionally, the relationship between hardiness, identity characteristics, and job factors was explored using a Pearson’s correlation and MANOVA. The study used valid and reliable instruments: the Maslach Burnout Inventory (MBI) to assess burnout and the Dispositional Resilience Scale (DRS) to assess hardiness. Results of a hierarchical multiple regression indicated that hardiness accounts for more of the variance in predicting burnout than self-care. Significant predictors of burnout include age, job satisfaction, self-care frequency, and hardiness. Data collected for this …

Establishing The Psychometric Properties Of The Understanding Mental Health Scale: A Dissertation Study, Michael Thomas Kalkbrenner

Counseling & Human Services Theses & Dissertations

The purpose of this dissertation study was to validate the Understanding Mental Health Scale (UMHS). The UMHS is a 50-item questionnaire that was designed to measure college students’ awareness of mental health issues. To test the psychometric properties of the UHMS, a principal axis factor (PAF) analysis with an oblique rotation was conducted using an existing data set of 350 college students. Results revealed a two-factor structure underlying college students’ understanding of mental health issues. The factors were named risk-factor awareness (familiarity with warning signs of mental health issues) and resource awareness (knowledge of resources for mental health issues). A …

Exploring The Relationship Between Depression And Resilience In Survivors Of Childhood Trauma, Marquis A. Norton

Counseling & Human Services Theses & Dissertations

Although experiences of trauma are common, reactions vary due to a host of biopsychosocial and cultural factors that influence the individual reaction to the trauma (Nakai et al., 2015). One such factor is resiliency, the capability to adapt in adverse environmental circumstances (Basim & Cetin, 2011). This study used hierarchical multiple regression to examine the relationships between childhood trauma, recent experiences of depression, and resilience in adult university students. This study also examined the possible moderating effects on depression by resilience. Participants completed the Childhood Trauma Questionnaire, Connor-Davidson Resilience scale, and PROMIS Depression survey. Small significant relationships were found for …

Understanding The Experiences Of Women With Anorexia Nervosa Who Complete An Exposure Therapy Protocol In A Naturalistic Setting, Gina B. Polychronopoulos

Counseling & Human Services Theses & Dissertations

Anorexia Nervosa (AN) is a serious mental health concern in the United States, with the highest mortality rate of all mental disorders. Females comprise the vast majority of people with AN, although the number of males with the condition is rising. Anorexia Nervosa has a high relapse rate and is often enduring, which makes it challenging to treat successfully; therefore, the mental health profession is in need of innovative therapeutic approaches. Exposure therapy has a growing evidence base for the treatment of eating disorders, including AN; however, there are very few studies that explore body image/mirror exposure specifically in patients …

Examining The Prevalence Rates Of Preexisting Maternal Medical Conditions And Pregnancy Complications By Source: Evidence To Inform Maternal And Child Research, Candace A. Robledo, Edwina H. Yeung, Pauline Mendola, Rajeshwari Sundaram, Nansi S. Boghossian, Erin M. Bell, Charlotte Druschel

School of Medicine Publications

Objectives—We sought to examine whether there are systematic differences in ascertainment of preexisting maternal medical conditions and pregnancy complications from three common data sources used in epidemiologic research

Methods—Diabetes mellitus, chronic hypertension, gestational diabetes mellitus (GDM), gestational hypertensive disorders (GHD), placental abruption and premature rupture of membranes (PROM) among 4821 pregnancies were identified via birth certificates, maternal self-report at approximately 4 months postpartum and by discharge codes from the Statewide Planning and Research Cooperative System (SPARCS), a mandatory New York State hospital reporting system. The kappa statistic (k) was estimated to ascertain beyond chance agreement of outcomes between birth certificates …

Genome-Wide Physical Activity Interactions In Adiposity ― A Meta-Analysis Of 200,452 Adults, Mariaelisa Graff, Robert A. Scott, Anne E. Justice, Kristin L. Young, Mary F. Feitosa, Llilda Barata, Thomas W. Winkler, Audrey Y. Chu, Anubha Mahajan, John Blangero

School of Medicine Publications

Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which …

Transcriptome Sequencing Study Implicates Immune-Related Genes Differentially Expressed In Schizophrenia: New Data And A Meta-Analysis, Alan R. Sanders, Eugene I. Drigalenko, Jubao Duan, Jessica Freda, Harald H. H. Goring, Pablo V. Gejman

School of Medicine Publications

We undertook an RNA sequencing (RNAseq)-based transcriptomic profiling study on lymphoblastoid cell lines of a European ancestry sample of 529 schizophrenia cases and 660 controls, and found 1058 genes to be differentially expressed by affection status. These differentially expressed genes were enriched for involvement in immunity, especially the 697 genes with higher expression in cases. Comparing the current RNAseq transcriptomic profiling to our previous findings in an array-based study of 268 schizophrenia cases and 446 controls showed a highly significant positive correlation over all genes. Fifteen (18%) of the 84 genes with significant (false discovery rateo0.05) expression differences between cases …

Appendicular Mass – A Rare Form Of Tuberculosis, Petrisor Banu, Vlad D. Constantin, Florian Popa, Mircea Bratucu, Teodora Vladescu, Cristian Balalau

Journal of Mind and Medical Sciences

Tuberculosis is in the top 10 causes of death worldwide, being one of the most deadly infectious diseases. It is estimated that one of three people from the entire earth population has a latent infection with M tuberculosis. This aerobic bacterium possesses the ability to persist in host tissues for years and to begin replication once immunity declines.

The lungs are most frequent site of infection as the Mycobacterium tuberculosis is carried by aerosol droplets and is commonly transmitted by respiratory route. The second way of transmission is by contaminated food.

Intestinal contamination coexists with pulmonary tuberculosis and only 10% …

Diagnostic Challenges And Treatment Difficulties In A Patient With Excoriated Acne Conglobata, Simona R. Georgescu, Maria I. Sârbu, Cristina I. Mitran, Mădălina I. Mitran, Vasile Benea, Mircea Tampa

Journal of Mind and Medical Sciences

Acne conglobata is a rare and severe form of acne vulgaris, characterized by the presence of comedones, papules, pustules, nodules and sometimes hematic or meliceric crusts. Acne excoriée is a form of self-inflicted skin condition in which the patient picks on imaginary or real acne lesions.

We report the case of a 16 year old Caucasian female patient from the urban area who addressed our dermatology department for erythematous, edematous plaques covered by pustules and crusts, located on the face. The anamnesis revealed that during the last weeks she had had a depressive mood after ending a relationship with her …

The Prevalence Of High Dysplastic Colonic Adenomatous Polyps In A 3 Year Endoscopic Retrospective Study From A Single Clinical Center, Alexandru C. Septimiu, Cosmin A. Moldovan, Florin D. Ungureanu

Journal of Mind and Medical Sciences

Introduction: Many colon neoplastic tumors come from the malignancy of adenomatous polyps (70%-90%) that were not timely diagnosed in order to be resected. Materials and Methods: We conducted a retrospective study regarding the incidence of adenomatous polyps during 1.000 consecutive colonoscopies performed in our Upper and Lower Digestive Endoscopy Laboratory during a three-year period. Results: During these colonoscopies, some targeted polyps were biopsied or completely removed and the samples had been sent to a complete anatomopathological examination. Taking into consideration the results, the polyps were classified after the histological type and the form of dysplasia, in order …

Melatonin Modulates Inflammatory Response And Suppresses Burn-Induced Apoptotic Injury, Ganka Bekyarova, Milena Atanasova, Maria Tzaneva, Anelia Dimitrova

Journal of Mind and Medical Sciences

Introduction: Melatonin, the principal secretory product of the pineal gland, has antioxidant functions as a potent antioxidant and free radical scavenger. Objectives of the present study were to investigate the effect of melatonin against inflammatory response, burn-induced oxidative damage and apoptotic changes of rat liver. Methods: Melatonin (10 mg /kg, i.p.) was applied immediately after 30% of total body surface area (TBSA) burns on male Wistar rats. The level of malondialdehyde (MDA) as a marker of an oxidative stress was quantified by thiobarbituric method. Hepatic TNFα and IL-10 as inflammatory markers were assayed by ELISA. Using light immunоchistochemistry …

An Evidence Based Guide To A Safe Intraoperative Approach Of Avoiding Iatrogenic Lesions During Difficult Laparoscopic Cholecystectomies, Cosmin Alec Moldovan, Roxana M. Duncea, Florin Dan Ungureanu, Vladimir Belis

Journal of Mind and Medical Sciences

Introduction: Although there are many sources for iatrogenic lesions during laparoscopic cholecystectomy, only a few stand out as being one of the most difficult to predict due to their nature of being very hard to diagnose before surgery. Materials and Methods: a short guide of cases with an evidence-based approach to avoid laparoscopic iatrogenic lesions. Results: these cases have been classified and presented into 3 main groups: cases with abnormal arterial layout, cases with heavy alteration of the normal anatomy, and cases with anomalies of the main biliary pathway. Conclusions: while not a complete guide covering …

Depression, Loneliness, And Pet Attachment In Homebound Older Adult Cat And Dog Owners, Sandy M. Branson, Lisa Boss, Stanley Cron, Dennis C. Turner

Journal of Mind and Medical Sciences

Background: Companion animals may reduce depression and loneliness in socially isolated homebound older adults. However, whether owning a cat or dog is more beneficial in this population remains unknown.

Materials and Methods: Pet attachment and the levels of depressive symptoms and loneliness were examined in 39 homebound older adults who exclusively owned a cat(s) or a dog(s). Cat owners (n = 12) and dog owners (n=27) were assessed for depressive symptoms (Geriatric Depression Scale-Short Form), loneliness (R-UCLA Loneliness Scale), and attachment to pets (Likert scale).

Results: Cat owners reported significantly lower levels of depressive symptoms than dog …

Natural Killer (Nk) Cells And Their Involvement In Different Types Of Cancer. Current Status Of Clinical Research, Isadora Zaharescu, Adina D. Moldovan, Cristiana Tanase

Journal of Mind and Medical Sciences

Natural killer cells are the main agents of innate immunity. Since 1970, various studies have repeatedly confirmed their involvement in decreasing local tumor growth and also decreasing the risk of metastasis, due to their cytotoxic effects and also through the release of immunostimulatory cytokines such as IFN-gamma. In the 1990s, several studies demonstrated the existence of certain inhibiting and stimulating receptors of these cells, leading to the concept of “induced self”, thus explaining why tumors with MHC-1 are destroyed and autologous cells without it are saved out. Recognition and destruction of tumor cells by the NK cells are the result …

High-Grade Cervical Dysplasia In Pregnancy – Psychological And Medical Challenges, Denisa O. Balalau, Romina M. Sima, Nicolae Bacalbasa, Petrisor Banu, Cristian Bălălău, Liana Ples, Anca D. Stanescu

Journal of Mind and Medical Sciences

Despite being rare, the incidence of pregnancy-related cancer is expected to rise as women continue to delay childbearing and give birth later in their reproductive years. In this broad category, tumors like breast cancer, dermatological neoplasia and cervical cancer are most common and tend to arise in women of childbearing age. All pregnant women with clinical and cytologic suspicion of cervical cancer, except for squamous atypia or low-grade squamous intraepithelial lesions, should undergo colposcopy, with or without biopsy, the latter being avoided if possible due to possible complications which, although rare, may involve preterm labor initiation.

Some studies have attempted …

Informational Dichotomy Of The Mind; The Role Of Sexual Neuromodulators, Ion G. Motofei, David L. Rowland

Journal of Mind and Medical Sciences

Many basic physiological mechanisms of sexuality were initially studied on animal subjects and conclusions regarding human subjects extrapolated afterward. These ancestral reflexes are assumed to have ascended during human evolution to the cerebral level, where cognition would intermediate (being an environmental operator) both sexual and mental processes. Accordingly, the study of human sexuality suggests an additional/ particular documentation regarding mental existence and its implication, phenomena that are not characteristic of animals.

In a previously published paper we presented ideas regarding the structural dichotomy of the mind and its subsequent implications to sexuality. In this paper we present a general perspective …

Forensic And Clinical Diagnosis In "Shaken Baby Syndrome", Between Child Abuse And Iatrogenic Abuse, Roxana M. Duncea, Irina Apostol, Relu G. Calota, Vladimir Belis

Journal of Mind and Medical Sciences

“Shaken baby syndrome” in child abuse cases is a challenge for pediatrician and forensic experts, often a diagnosis of exclusion, with overwhelming moral and legal implications. Diagnosis is based on: subdural bleeding, rupture of retinal vessels, traumatic diffuse axonal injury with diffuse brain encephalopathy in the absence of external traumatic injuries and anamnesis data of an accidentally head injury.

Microscopic findings in diffuse axonal injuries were initially considered as a specific traumatic effect due to unrestricted movement and accelerated rotation of the head. Immunohistochemistry of beta amyloid protein precursor is gold standard method for identifying pathological diffuse axonal lesions, which …

Adverse Reactions Of Biological Therapies In Patients With Psoriasis, Maria I. Sârbu, Mircea Tampa, Mădălina I. Mitran, Cristina I. Mitran, Alexandra M. Limbău, Simona R. Georgescu

Journal of Mind and Medical Sciences

Psoriasis is a chronic, immune-mediated disorder characterized by well demarcated, erythematous plaques covered by thick, silvery-white scales, most often located on the knees, elbows, sacral area and scalp. It has a significant impact on the patient's quality of life.

Biological therapies revolutionized the treatment of psoriasis vulgaris but there has been concern regarding the use of those agents due to severe adverse reactions reported in patients receiving TNF-α inhibitors for various inflammatory diseases.

The aim of this paper is to review the most important adverse reactions reported in patients receiving biological treatments. The most common and severe side effects associated …

Journal Of Mind And Medical Sciences: Translational And Integrative Mission, David L. Rowland, Ion G. Motofei

Journal of Mind and Medical Sciences

Initiated four years ago, Journal of Mind and Medical Sciences (J Mind Med Sci.) established the mission to publish papers on mental and medical topics in distinct but closely interrelated domains. The editorial policy especially encourages interdisciplinary and integrative perspectives, being equally focused on basic research and clinical investigations and short reports.

The journal adheres to the philosophy that high quality, original ideas and information should be readily accessible and freely shared within and amongst the scientific community. Accordingly, J Mind Med Sci. is an online, open access, non-for-profit journal which, because of individual/ private support, has levied no charges …

Undergraduate Research On General Aviation Hypoxia: A Student’S Perspective, Claire Schindler

Discovery Day - Prescott

During the fall academic term of 2016, an opportunity arose through the College of Aviation to serve as an undergraduate research assistant. Through discussion with faculty mentors, it was decided that a severely overlooked aspect of the aviation industry was survivors of hypoxia, especially in the less regulated general aviation community. The problem this study addresses is the uncertainty of the common circumstances that general aviation pilots find themselves in that create a hypoxic state, as well as whether or not that pilot reported the occurrence to the proper establishments. The results of this study showed not only those that …

The Healing Nature Of Occupation, Jennifer Fortuna

The Open Journal of Occupational Therapy

Moses Hamilton, an artist based in Hawaii, provided the cover art for the Spring 2017 edition of The Open Journal of Occupational Therapy (OJOT). “Pali Kai” is a 11”x14” painting made from acrylic on canvas. When a tragic car accident left Hamilton paralyzed from the chest down, mouth painting provided an outlet for self-expression and stress relief. Participation in a meaningful occupation helped Hamilton find his path in life. With their colorful impressionist-style, Hamilton’s paintings have brought happiness to people all over the world.

Eudemonic Care: A Future Path For Occupational Therapy?, Charlotte L. Royeen, Franklin Stein, Alivia Murtha, Julie Stambaugh

The Open Journal of Occupational Therapy

The core tenets of occupational therapy date to ancient Greece. Philosophers and physicians alike promulgated that quality of life, or “eudemonia,” is at the center of both ethical and medical concern and can be attained through healthful engagement in meaningful occupation. In more recent times, there has been a strong call to return to the powerful implementation of the eudemonic moral philosophy in health care practice, especially in occupational therapy. Searches of recent occupational therapy research show that integration of wellness initiatives into rehabilitative treatment sessions can have a profound impact on the physical and emotional healthfulness of people with …

How Society’S Philosophy Has Shaped Occupational Therapy Practice For The Past 100 Years, Jim Hinojosa

The Open Journal of Occupational Therapy

The Anne Cronin Mosey lecture seeks to stimulate provocative thinking about issues important to occupational therapy. The speaker is asked to raise a controversial issue and provide a perspective that may challenge many in the audience. In this paper, I examine occupational therapy practice in the context of the dominant philosophical movement of American society. The first part presents the influence of America’s dominant philosophical movements on the profession: pragmatism (1917), modernism (1940), and, currently, postmodernism. I propose that occupational therapy’s acceptance of modernism has resulted in two major opposing viewpoints, prompting polarization and fragmentation in the profession. I argue …

Awareness And Use Of Electronic Health Records In Entry-Level Occupational Therapy And Occupational Therapy Assistant Curricula, Louis F. Dmytryk, Tina M. Deangelis

The Open Journal of Occupational Therapy

The Accreditation Council for Occupational Therapy Education (ACOTE) requires programs to instruct entry-level occupational therapy (OT) and occupational therapy assistant (OTA) students in technology that may include electronic documentation systems, distance communication, virtual environments, and telehealth (standard B1.8). At this time, there are no publications describing if and how electronic health record (EHR) instruction is implemented in entry-level OT and OTA programs. The purpose of this study is to investigate awareness and use of EHRs in entry-level OT and OTA curricula. Respondents from 76 nationally accredited entry-level programs (two OT doctoral, 24 OT masters, two OT combined bachelors/masters, and 48 …

Past Negative Time Perspective As A Predictor Of Grade Point Average In Occupational Therapy Doctoral Students, Pat J. Precin

The Open Journal of Occupational Therapy

Time perspective is a fundamental dimension in psychological time, dividing human experiences into past, present, and future. Time perspective influences individuals’ functioning in all occupations, including education. Previous research has examined the relationship between time perspective and academic outcomes, but the same research has not been done, to date, with occupational therapy doctoral students. This quantitative, cross-sectional study investigated the relationship between time perspective and academic success in occupational therapy doctoral students across the United States. Data from the Zimbardo Time Perspective Inventory (ZTPI) and grade point averages (GPAs) were collected from 50 participants via surveymonkey.com. Past Negative time perspective …