Medicine and Health Sciences Commons^™

Merging Human Becoming Theory And Health Coaching Principles Into The Role Of The Family Nurse Practitioner, Tammy Lee Olney

Theses and Graduate Projects

Family Nurse Practitioners have limited time with patients to address their health care concerns. Practitioners need to make the most of this limited time in order to promote positive patient outcomes. Health coaching is a proven method to assist others in identifying obstacles, prioritize what is important to them, leverage strengths, and in making healthy behavior changes. Drawing on evidenced-based practice in health coaching assists the Family Nurse Practitioner with making deeper connections with patients and guides in co-creating a plan that is truly patient-centered. The health coaching process is in parallel with the Human Becoming Theory by the use …

Open Your Eyes: Recognizing The Signs And Symptoms Of Human Trafficking, Elizabeth M. Stanek

Theses and Graduate Projects

Human trafficking is both a human rights violation and a major public health concern. Trafficking in persons, prevalent both domestically and internationally, is a form of modern-day slavery. Although there are different typse of human trafficking, the most prevalent is the recruitment of girls and boys to be used in sex trafficking. This form of human trafficking uses force, violence, fraud, and coercion to control the victims and keep them from from contacting law enforcement or seeking help. Knowledge and awareness of signs and symptoms of human trafficking are crucial for doctor of nursing practice-family nurse practitioners (DNP-FNP), as they …

Mindfulness, Movement, & Music: Implementing A Yoga Program For Children, Briana Darcy

Theses and Graduate Projects

The prevalence of stress-related physical and psychological diseases is continually increasing. Underserved children have a high risk for developing stress-related conditions as a result of multiple social, physiological, and environmental factors. This DNP/FNP scholarly project focuses on the stress-reducing effects of the integrative therapies of yoga, meditation, music, and mindfulness. A program includes concepts of yoga, meditation, mindfulness and music listening to provide children with low-cost coping techniques that help combat the ill effects of stress in their lives. It was implemented in Rochester, MN. Participant reactions were favorable, as well as evaluations by faculty at the place of implementation. …

Jefferson College Of Population Health Capstones New To The Jefferson Digital Commons, Daniel G. Kipnis, Msi

Jefferson Digital Commons News

A new batch of capstone presentations from the Jefferson College of Population Health have been loaded in the Jefferson Digital Commons:

MPH Capstone Presentations:

• Borders and Blood Pressure: Identifying the Association of Acculturation with Hypertension Diagnoses Among Hispanic-American Immigrants
• Partnerships to Improve Community Health (PICH) Initiative on Nutrition in Wilmington, DE: An Assessment of Fruit and Vegetable Consumption
• Perceptions of Living with Chronic Illness as Type 2 Diabetic Transgender Adults
• Addressing Obesity in the Early Head Start Community Through Environmental and Educational Means (Pilot Program)
• Screening for Adolescent Alcohol and Other Drug Use by Jefferson Providers: Methods, Barriers and …

Association Between Vitamin D And Utis, Elizabeth Harding

Student Works

Urinary tract infections are a common infection that can have serious sequela. Many populations are susceptible to urinary tract infections. This article reviews emerging research that optimizing vitamin D levels can decrease risk of developing urinary tract infections. Recommendations are made for the health care provider based on the review of research.

Longitudinal Peripheral Blood Transcriptional Analysis Of A Patient With Severe Ebola Virus Disease., John C Kash, Kathie-Anne Walters, Jason Kindrachuk, David Baxter, Kelsey Scherler, Krisztina B Janosko, Rick D Adams, Andrew S Herbert, Rebekah M James, Spencer W Stonier, Matthew J Memoli, John M Dye, Richard T Davey, Daniel S Chertow, Jeffery K Taubenberger

Articles, Abstracts, and Reports

The 2013-2015 outbreak of Ebola virus disease in Guinea, Liberia, and Sierra Leone was unprecedented in the number of documented cases, but there have been few published reports on immune responses in clinical cases and their relationships with the course of illness and severity of Ebola virus disease. Symptoms of Ebola virus disease can include severe headache, myalgia, asthenia, fever, fatigue, diarrhea, vomiting, abdominal pain, and hemorrhage. Although experimental treatments are in development, there are no current U.S. Food and Drug Administration-approved vaccines or therapies. We report a detailed study of host gene expression as measured by microarray in daily …

Proceedings - Wright State University Boonshoft School Of Medicine Ninth Annual Medical Student Research Symposium: Celebrating Medical Student Scholarship, Office Of Research Affairs, Boonshoft School Of Medicine

Medical Student Research Symposium Proceedings

The student abstract booklet is a compilation of abstracts from students' oral and poster presentations at Wright State University's Ninth Annual Boonshoft School of Medicine Medical Student Research Symposium held on April 12, 2017.

Multiple Large Perineural (Tarlov) Cysts In The Sacrum Of A Cadaver: A Case Report And Review., Jocelyn Gonzales, Joe Iwanaga, Nitsa Topale, Rod J Oskouian, R Shane Tubbs

Articles, Abstracts, and Reports

Tarlov or perineural cysts are cerebrospinal fluid (CSF)-filled sacs found between the perineurium and epineurium of the nerve roots. It is still unsure whether the origin of these cysts is intradural or extradural. They can either be asymptomatic or create a variety of negative impacts on comfort and quality of life. In this case report, we describe the presentation of multiple Tarlov cysts including one large cyst discovered during a routine cadaveric spinal dissection and the relevant and related literature. To our knowledge, this is the only cadaveric case report of Tarlov cysts and offers an interesting window into their …

Metformin Versus Lifestyle Modification In The Treatment Of Type 2 Diabetes In Youth, Coralyn Jensen Kurtz

Nursing Capstones

No abstract provided.

Cyclosporine Exacerbates Ketamine Toxicity In Zebrafish: Mechanistic Studies On Drug–Drug Interaction, Bonnie L. Robinson, Melanie Dumas, Syed F. Ali, Merle G. Paule, Qiang Gu, Jyotshna Kanungo

United States Food and Drug Administration: Publications

Cyclosporine A (CsA) is an immunosuppressive drug commonly used in organ transplant patients to prevent allograft rejections. Ketamine is a pediatric anesthetic that noncompetitively inhibits the calcium-permeable N-methyl-^_D-aspartic acid receptors. Adverse drug–drug interaction effects between ketamine and CsA have been reported in mammals and humans. However, the mechanism of such drug–drug interaction is unclear. We have previously reported adverse effects of combination drugs, such as verapamil/ketamine and shown the mechanism through intervention by other drugs in zebrafish embryos. Here, we show that ketamine and CsA in combination produce developmental toxicity even leading to lethality in zebrafish larvae …

Targeting The Pd-1 Pathway In Pediatric Solid Tumors And Brain Tumors, Lars M. Wagner, Val R. Adams

Pediatrics Faculty Publications

While remarkable advances have been made in the treatment of pediatric leukemia over the past decades, new therapies are needed for children with advanced solid tumors and high-grade brain tumors who fail standard chemotherapy regimens. Immunotherapy with immune checkpoint inhibitors acting through the programmed cell death-1 (PD-1) pathway has shown efficacy in some chemotherapy-resistant adult cancers, generating interest that these agents may also be helpful to treat certain refractory pediatric malignancies. In this manuscript we review current strategies for targeting the PD-1 pathway, highlighting putative biomarkers and the rationale for investigation of these drugs to treat common pediatric tumors such …

The Advantages And Disadvantages Of Pharmacological Treatment For Hypertension In Children And Adolescents, Brittany J. Haugtvedt

Nursing Capstones

No abstract provided.

The Lived Experience Of Relationship Transition In Significant Others Caring For A Partner With Younger Onset Dementia, Diane Peyser

Theses & Dissertations

Background

Approximately 5% of dementia sufferers are individuals younger than age 65. The majority of studies have focused on individuals with late-onset dementia. The limited studies conducted on caregivers of younger onset dementia individuals identify that they have a different set of needs based upon their unique experiences. Significant others such as spouses frequently fulfill the role of caregiver for a partner with younger onset dementia. Little is known about the lived experience of significant others caring for a partner with younger onset dementia in the context of relationship transition that occurs in this dynamic situation. This study illustrates the …

A Comparison Of Two Debriefing Methods On Clinical Reasoning Outcomes, Learner Satisfaction With Debriefing And Reflection, Clinical Learning And Clinical Reasoning, And Psychological Safety Of Nurse Orientees In Simulation-Based Education, Lori Persico

Theses & Dissertations

Simulation-based education is a teaching method used successfully in military, aviation, and medical education; however, the evidence rarely indicates how debriefing affects the learners’ experiences. Debriefing is an essential component of simulation-based education that fosters conceptual learning, critical thinking, and clinical reasoning. The purpose of this study was to compare the effects of two different debriefing methods on nurses’ perceptions of psychological safety, satisfaction with development of clinical reasoning skills, and satisfaction with learning. In this quasi-experimental, posttest study the researcher explored the effect of each debriefing method. Using the 18-item Satisfaction with Simulation Experience Scale developed by Levett-Jones et …

Lysine Residues Of Interferon Regulatory Factor 7 Affect The Replication And Transcription Activatormediated Lytic Replication Of Kaposi’S Sarcomaassociated Herpesvirus/Human Herpesvirus 8, Tianzheng Zhang, Ying Wang, Li Zhang, Bin Liu, Jinhui Xie, Charles Wood, Jinzhong Wang

Nebraska Center for Virology: Faculty Publications

Kaposi’s sarcoma-associated herpesvirus (KSHV) infection goes through latent and lytic phases, which are controlled by the viral replication and transcription activator (RTA). Upon KSHV infection, the host responds by suppressing RTA-activated lytic gene expression through interferon regulatory factor 7 (IRF-7), a key regulator of host innate immune response. Lysine residues are potential sites for post-translational modification of IRF-7, and were suggested to be critical for its activity. In this study, we analysed the 15 lysine residues for their effects on IRF-7 function by site-directed mutagenesis. We found that some mutations affect the ability of IRF-7 to activate interferon (IFN)-a1 and …

Rhetorical Analysis Of The Nra's Use Of Mentally Ill As A Scapegoat For Gun Violence, Emma Patrone

SCOM Undergraduate Research Conference

This paper is a rhetorical analysis of the NRA's use of the mentally ill as a scapegoat for gun related violence within the U.S.

Group Education In Hypertension, Abby Lara

Scholars Week

Abstract Title: Group Education in Hypertension

Presenter: Abby Noisworthy APRN, FNP-BC

Category: Clinical Concerns for Practicing APRNs

Purpose/Goal Statement: Evaluate the effectiveness of group education in improving knowledge and self-reported compliance.

Clinical Question: In hypertensive patients, does increased education, including group educational seminars, increase knowledge and therefore self-reported compliance?

Methods: 45-minute group seminar designed to increase knowledge and promote compliance. Pre- and post-tests administered to evaluate effectiveness. Pre- and post-test means were calculated using Microsoft Excel. Eight-week follow up phone calls were made to evaluate self-reported compliance.

Findings: Mean pre-test score was 69%. Mean post-test score was 98%. A 29% …

Speech-Language Pathologists’ Estimates Of Bolus Sizes Used During Dysphagia Evaluations, Joyanna E. Struzzieri

Theses & Honors Papers

Dysphagia evaluations play an important role in the assessment and treatment of people with swallowing problems. Protocols and methods for assessment vary greatly among clinicians, however, all assessments involve trials of food and liquid boluses given across different consistencies and in varying amounts. Thin and thick liquids, thin puree, thick puree or pudding, and solid consistencies are widely utilized for dysphagia evaluations. The amounts of food and liquids that are given drive therapeutic recommendations for bite and sip sizes. It is unknown if the bite and sip sizes used during dysphagia assessments also vary among SLPs and/or if these amounts …

Inhibition Of Vegf And Angiopoietin-2 To Reduce Brain Metastases Of Breast Cancer Burden, Kaci A. Bohn, Chris E. Adkins, Mohamed I. Nounou, Paul R. Lockman

Clinical and Translational Science Institute

For metastases in the central nervous system, angiogenesis enhances metastatic potential and promotes progression. Primary factors which drive vessel growth are vascular endothelial growth factor (VEGF) and angiopoietin-2. Preclinical models show inhibition of either factor reduces metastases spread and inhibits growth. This work sets out to answer two questions in a preclinical mouse model. First, whether the combined inhibition of VEGF and angiopoietin-2, reduces passive permeability and limits drug uptake into brain metastases; and second, whether this inhibition reduces metastases burden in brain. We observed combinatorial inhibition of VEGF and angiopoietin-2, decreased (p < 0.05) angiogenesis and vascular branching in an aortic ring assay and decreased (p < 0.05) endothelial wound closure times. Using a brain metastases of breast cancer model (induced by intracardiac injections of brain seeking MDA-MB-231Br cells or 4T1Br cells), we observed, similar to VEGF, angiopoetin-2 expression correlates to increased angiogenesis (p < 0.05) and increased lesion permeability. To determine efficacy, animals were administered bevacizumab plus L1-10 (angiopoietin inhibitor) twice per week until neurological symptoms developed. Lesion permeability significantly decreased by ∼50% (p < 0.05) compared to untreated lesions, but remained ∼25% greater (p < 0.0%) than brain. In subsequent experiments, animals were administered similar regimens but sacrificed on day 32. The number of metastatic lesions developed was significantly (p < 0.001) reduced in the bevacizumab group (56%) and combination group (86%). Lesions’ size was reduced in bevacizumab treated lesions (∼67%) and bevacizumab and L1-10 treated lesions (∼78%) developing area < 0.5 mm2. In summary, combinatorial inhibition of VEGF and angiopoietin reduces lesion permeability and brain metastatic burden.

Fabrication Of Extracellular Matrix-Derived Foams And Microcarriers As Tissue-Specific Cell Culture And Delivery Platforms, Anna Kornmuller, Cody F.C. Brown, Claire Yu, Lauren E. Flynn

Bone and Joint Institute

© 2017 Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Cell function is mediated by interactions with the extracellular matrix (ECM), which has complex tissue-specific composition and architecture. The focus of this article is on the methods for fabricating ECM-derived porous foams and microcarriers for use as biologically-relevant substrates in advanced 3D in vitro cell culture models or as pro-regenerative scaffolds and cell delivery systems for tissue engineering and regenerative medicine. Using decellularized tissues or purified insoluble collagen as a starting material, the techniques can be applied to synthesize a broad array of tissue-specific bioscaffolds with customizable geometries. The approach involves mechanical …

Positive Affect Predicts Cerebral Glucose Metabolism In Late Middle-Aged Adults., Christopher Nicholas, Siobhan M Hoscheidt, Lindsay R Clark, Annie M Racine, Sara E Berman, Rebecca L Koscik, N Maritza Dowling, Sanjay Asthana, Bradley T Christian, Mark A Sager, Sterling C Johnson

GW Biostatistics Center

Positive affect is associated with a number of health benefits; however, few studies have examined the relationship between positive affect and cerebral glucose metabolism, a key energy source for neuronal function and a possible index of brain health. We sought to determine if positive affect was associated with cerebral glucose metabolism in late middle-aged adults (n = 133). Participants completed the positive affect subscale of the Center for Epidemiological Studies Depression Scale at two time points over a two-year period and underwent 18F-fluorodeoxyglucose-positron emission tomography scanning. After controlling for age, sex, perceived health status, depressive symptoms, anti-depressant use, family …

Unmet Need For Surgery In South Asia, Sanjay Nagral, Maharra Hussain, Sarder A. Nayeem, Ranjan Dias, S. Ather Enam, Samiran Nundy

Section of Neurosurgery

No abstract provided.

Raising Taxes Key To Accelerate Tobacco Control In South Asia, Prabhat Jha, Javaid Khan, Sujata Mishra, Prakash Gupta

Section of Pulmonary & Critical Care

No abstract provided.

Diabetes, Cardiovascular Disease, And Chronic Kidney Disease In South Asia: Current Status And Future Directions, Anoop Misra, Nikhil Tandon, Shah Ebrahim, Naveed Sattar, Dewan Alam, Usha Shrivastava, K M Venkat Narayan, Tazeen H. Jafar

Section of Pulmonary & Critical Care

No abstract provided.

Structure Of Nascent Chromatin Is Essential For Hematopoietic Lineage Specification., Svetlana Petruk, Samanta A. Mariani, Marco De Dominici, Patrizia Porazzi, Valentina Minieri, Jingli Cai, Lorraine Iacovitti, Neal Flomenberg, Bruno Calabretta, Alexander Mazo

Department of Cancer Biology Faculty Papers

The role of chromatin structure in lineage commitment of multipotent hematopoietic progenitors (HPCs) is presently unclear. We show here that CD34(+) HPCs possess a post-replicative chromatin globally devoid of the repressive histone mark H3K27me3. This H3K27-unmodified chromatin is required for recruitment of lineage-determining transcription factors (TFs) C/EBPα, PU.1, and GATA-1 to DNA just after DNA replication upon cytokine-induced myeloid or erythroid commitment. Blocking DNA replication or increasing H3K27me3 levels prevents recruitment of these TFs to DNA and suppresses cytokine-induced erythroid or myeloid differentiation. However, H3K27me3 is rapidly associated with nascent DNA in more primitive human and murine HPCs. Treatment of …

Mental Illness And Injuries: Emerging Health Challenges Of Urbanisation In South Asia, Devaki Nambiar, Junaid Razzak, Kaosar Afsana, Alayne M. Adams, Arif Hasan, Dinesh Mohan, Vikram Patel

Department of Emergency Medicine

No abstract provided.

Bitter Taste Receptor Agonists Mitigate Features Of Allergic Asthma In Mice., Pawan Sharma, Roslyn Yi, Ajay P Nayak, Nadan Wang, Francesca Tang, Morgan J. Knight, Shi Pan, Brian Oliver, Deepak A. Deshpande

Department of Medicine Faculty Papers

Asthma is characterized by airway inflammation, mucus secretion, remodeling and hyperresponsiveness (AHR). Recent research has established the bronchodilatory effect of bitter taste receptor (TAS2R) agonists in various models. Comprehensive pre-clinical studies aimed at establishing effectiveness of TAS2R agonists in disease models are lacking. Here we aimed to determine the effect of TAS2R agonists on features of asthma. Further, we elucidated a mechanism by which TAS2R agonists mitigate features of asthma. Asthma was induced in mice using intranasal house dust mite or aerosol ova-albumin challenge, and chloroquine or quinine were tested in both prophylactic and treatment models. Allergen challenge resulted in …

The Design Of An Evidence-Based Protocol For Primary Care Of Patients With Dementia, Kaitlin B. Demaagd

Doctoral Projects

Improvement in the effectiveness and optimization of care outcomes for patients with dementia in primary care is a national priority (American Medical Association-convened Physician Consortium for Performance Improvement [PCPI], 2014). Alzheimer’s disease affects more than 5 million Americans. Patients with dementia cost the nation $236 billion in 2016 (Alzheimer’s Association, 2016). In 2014, the PCPI developed ten evidence-based recommendations to address the gaps in outpatient dementia care called the Dementia Performance Measure Set (DPMS). An independently owned, non-system affiliated primary care practice identified the need to improve the quality of care they provide to their patients with dementia and their …

Duty Hours: More Rest? More Sleep? Less Learning?, Enrique Gomez-Pomar

Pediatrics Faculty Publications

No abstract provided.

Granulosa Cell Endothelin-2 Expression Is Fundamental For Ovulatory Follicle Rupture, Joseph A. Cacioppo, Po-Ching Patrick Lin, Patrick R. Hannon, Daniel R. Mcdougle, Arnon Gal, Chemyong Ko

Obstetrics and Gynecology Faculty Publications

Ovulation is dependent upon numerous factors mediating follicular growth, vascularization, and ultimately oocyte release via follicle rupture. Endothelin-2 (EDN2) is a potent vasoconstrictor that is transiently produced prior to follicle rupture by granulosa cells of periovulatory follicles and induces ovarian contraction. To determine the role of Edn2 expression, surgical transplant and novel conditional knockout mice were super-ovulated and analyzed. Conditional knockout mice utilized a new iCre driven by the Esr2 promoter to selectively remove Edn2. Follicle rupture and fertility were significantly impaired in the absence of ovarian Edn2 expression. When ovaries of Edn2KO mice were transplanted in wild type …