Medicine and Health Sciences Commons^™

A Ruptured Basilar Aneurysm Resulting In Takotsubo Cardiomyopathy., Ryan Murphy Do, Apurva Vyas Md, Megan Leary Md

Department of Medicine

No abstract provided.

Cardiac Sarcoidosis Mimicking Arrhythmogenic Right Venticular Dysplasia., Ross Biggs Do, Brijesh Patel Md, Matthew W. Martinez Md, Matthew Mccambridge Md, Susan Kim Md, Norman Marcus Md

Department of Medicine

No abstract provided.

An Unfortunate Case Of A Fallen Spartan., Travis Magdaleno Md, Noor Salam Md

Department of Medicine

No abstract provided.

Accelerating Hpv Vaccine Compliance With The Usage Of Mylvhn Patient Portal., Kimberly M. Rarick Do Pgy-3, Matthew Saltz Md

Department of Pediatrics

No abstract provided.

Development And Psychometric Testing Of An Instrument To Compare Career Choice Influences And Perceptions Of Nursing Among Healthcare Students, Sok Ying Liaw, Ling Ting Wu, Violeta Lopez, Yeow Leng Chow, Siriwan Lim, Eleanor Holroyd, Khoon Kiat Tan, Wenru Wang

School of Nursing & Midwifery, East Africa

Background: With the availability of more healthcare courses and an increased intake of nursing students, education institutions are facing challenges to attract school leavers to enter nursing courses. The comparison of career choice influences and perception of nursing among healthcare students can provide information for recruitment strategies. An instrument to compare the influences of healthcare career choice is lacking. The purpose of this study is to develop and evaluate the psychometric properties of an instrument to compare the influences of healthcare career choice with perceptions of nursing as a career choice.

Methods: The study was conducted in two phases. In …

Decreased Body Mass Index In The Preclinical Stage Of Autosomal Dominant Alzheimer's Disease, Stephan A. Müller, Oliver Preische, Hamid R. Sohrabi, Susanne Gräber, Mathias Jucker, Janko Dietzsch, John M. Ringman, Ralph Martins, Eric M. Mcdade, Peter R. Schofield, Bernardino F. Ghetti, Martin N. Rossor, Neill R. Graff-Radford, Johannes Levin, Douglas R. Galasko, Kimberly A. Quaid, Stephen P. Salloway, Chengjie Xiong, Tammie L. Benzinger, Virginia D. Buckles, C. L. Masters, Reisa A. Sperling, Randall J. Bateman, John C. Morria, Christoph Laske

Research outputs 2014 to 2021

The relationship between body-mass index (BMI) and Alzheimeŕs disease (AD) has been extensively investigated. However, BMI alterations in preclinical individuals with autosomal dominant AD (ADAD) have not yet been investigated. We analyzed cross-sectional data from 230 asymptomatic members of families with ADAD participating in the Dominantly Inherited Alzheimer Network (DIAN) study including 120 preclinical mutation carriers (MCs) and 110 asymptomatic non-carriers (NCs). Differences in BMI and their relation with cerebral amyloid load and episodic memory as a function of estimated years to symptom onset (EYO) were analyzed. Preclinical MCs showed significantly lower BMIs compared to NCs, starting 11.2 years before …

Are Education And Work Process Redesign Effective In Increasing Documentation Of Annual Retinal Exams Among Diabetic Patients?, Stacy Screws

Doctor of Nursing Practice Projects

Annual retinal eye exams are one of the key strategies in controlling vision loss due to diabetes. The American Diabetes Association (ADA) states that in order to “provide high-quality diabetes care, practitioners need information systems that help them track patient progress toward goals, as well as tools to help them meet those goals.” The electronic medical record (EMR) is a mainstay of healthcare today but the basic utilization of a EMR does not necessarily change the quality of care that patients receive. The purpose of this project was to determine if education and work process redesign are effective in increasing …

Manual Trans-Tracheal High Frequency Positive Pressure Ventilation For Left Main Bronchus And Carinal Mass Surgical Resection In A Child, Mohammad Irfan Akhtar, Faisal Junejo, Hamid Iqil Naqvi, Mohammad Hamid

Department of Anaesthesia

Inflammatory myofibroblastic tumor (IMT), also called pseudo-tumor, is a very rare condition and accounts for less than 1% of primary lung tumor. It is most common benign tumor of lung in children. This case is reported with the objective of highlighting the role of manual trans-tracheal high frequency positive pressure ventilation (HFPPV) in facilitating surgical resection with maintenance of adequate oxygenation and a little compromised ventilation. A 9-year boy, weighing 21 kg, was diagnosed as a case of IMT of left main bronchus on biopsy and was successfully treated by surgical excision through left thoracotomy. HFPPV through improvised technique was …

Kinematics Of The Lower Extremities During Fundamental Martial Arts Tricking Techniques, Kevin P. Grassie

Honors Scholar Theses

Martial Arts Tricking (MAT) is a relatively new sport that combines martial arts, gymnastics, acrobatics, and breakdancing for the purposes of creating aesthetic and impressive combinations of kicks, flips and twists. It has been growing exponentially through social media and the overall athletic and entertainment communities. The sport is very unique in that the movements, with their blended influences, provide novel ways for athletes to generate and utilize their momentum in a creative way. The results often include off-axis flips and twists, single-leg landings, and complicated yet fluid techniques that easily chain together.

Due to the sport only being a …

Mental Health Rehabilitation In Victims Of Sex Trafficking, Kayla E. Freemire

Senior Honors Theses

Human trafficking is a global epidemic that leaves victims with short- and long-term physiological, psychological, and sociological issues. The mental health needs of trafficked persons have become a topic of research in both medical and psychiatric circles. In order to comprehensively understand the mental health consequences of trafficking, the process must be defined and related to the mental health effects on its victims. The specific mental health disorders diagnosed within this population will be discussed. Treatments used currently for this population will be reviewed, along with future treatments presently being researched and evaluated regarding their potential for use in the …

The Role Of Metastasis Suppressor Cd82 In The Deactivation Of The C-Met Signaling Pathway In Prostate Cancer, Katie L. Uhl

Masters Theses

BACKGROUND AND PURPOSE: Prostate cancer is the second leading cause of cancer deaths among men in the United States. Metastasis plays a major role in patient prognosis and treatment options. One of the factors that influences metastasis is the activation of the c-Met signaling pathway. Activation of the growth factor c-Met results in cytoskeletal rearrangement, migration, and invasion. Previous studies have shown CD82 to act as an active metastatic suppressor in normal, healthy cells and is downregulated in various forms of cancer. When CD82 is re-expressed in cancer cells, the cells no longer express metastatic characteristics. The purpose of this …

Determinants Of Modern Contraceptive Use Among Sexually Active Men In Kenya, Rhoune Ochako, Marleen Temmerman, Mwende Mbondo, Ian Askew

Obstetrics and Gynaecology, East Africa

Background: Research in Kenya has focussed on family planning from women’s perspectives, with the aim of helping reduce the burden of unintended pregnancies. As such, the determinants of modern contraceptive use among sexually active women are well documented. However, the perspectives of men should be considered not only as women’s partners, but also as individuals with distinct reproductive histories and desires of their own. This study seeks to understand the determinants of modern contraceptive use among sexually active men, by exploring factors that are correlated with modern contraceptive use.

Methods: The data source is the nationally representative 2014 Kenya Demographic …

Recognizing Kikuchi Disease: An Unusually Severe Case., Thomas Quinn Do, Samer Bolis Do, Marie S. O’Brien Do

Department of Medicine

No abstract provided.

Post-Transfusion Purpura: A Rare Cause Of Severe Thrombocytopenia., Rachel Kinney Do, Bala Carver Md

Department of Medicine

No abstract provided.

Multiple Large Lung Cavitary Lesions Due To Streptococcus Intermedius In An Otherwise Healthy Young Male., Deepika Jain Md, Matthew Miles Do, Andres Zirlinger Md

Department of Medicine

No abstract provided.

Mindfulness Program For Student Athletes, Daniel J. Savory

M.A. in Leadership Studies: Capstone Project Papers

Student athletes face challenging situations during their time at college which can cause their experience to be a negative one if they are not fully supported. This can be due to several factors; most athletes face an immense amount of pressure to succeed in the classroom as well as in their sport. Also, many athletes are moving away from home for the first time and this can be a daunting feeling. They are expected to manage all of these challenges, and if mishandled, it can lead to an overwhelming amount of negative stress resulting in an unsuccessful time as a …

Osa And Primary Snoring: Palatal Surgery And Office-Based Procedures, Adam Vasconcellos, Md

Department of Otolaryngology - Head and Neck Surgery Presentations and Grand Rounds

PowerPoint slide deck. (No audio)

The Malaria Testing And Treatment Landscape In Benin., Kathryn A. O'Connell, Vamsi Vasireddy, Megan Littrell, Andria Rusk, Actwatch Group, Cyprien Zinsou, Adjibabi Bello Cherifath

Collected Faculty Scholarship

BACKGROUND: Since 2004, artemisinin-based combination therapy (ACT) has been the first-line treatment for uncomplicated malaria in Benin. In 2016, a medicine outlet survey was implemented to investigate the availability, price, and market share of anti-malarial treatment and malaria diagnostics. Results provide a timely and important benchmark to measure future interventions aimed at increasing access to quality malaria case management services.

METHODS: Between July 5th to August 6th 2016, a cross sectional, nationally-representative malaria outlet survey was conducted in Benin. A census of all public and private outlets with potential to distribute malaria testing and/or treatment was implemented among 30 clusters …

Irritable Bowel Syndrome: Clinical Manifestations, Dietary Influences, And Management., Ronald Ikechi, Bradford D Fischer, Joshua Desipio, Sangita Phadtare

Cooper Medical School of Rowan University Departmental Research

Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder that is characterized by symptoms of chronic abdominal pain and altered bowel habits in the absence of an overtly identifiable cause. It is the most commonly diagnosed functional gastrointestinal disorder, accounting for about one third of gastroenterology visits. It generally presents as a complex of symptoms, including psychological dysfunction. Hypersensitivity to certain foods, especially foods that contain high amounts of fructose, plays a role in the pathophysiology of IBS. Elevated consumption of high-fructose corn syrup (HFCS) has been discussed in this aspect. The treatment options for IBS are challenging and varied. …

Bk Channels Mediate Synaptic Plasticity Underlying Habituation In Rats, Tariq Zaman, Cleusa De Oliveira, Mahabba Smoka, Chakravarthi Narla, Michael O. Poulter, Susanne Schmid

Anatomy and Cell Biology Publications

Habituation is a basic form of implicit learning and represents a sensory filter that is disrupted in autism, schizophrenia, and several other mental disorders. Despite extensive research in the past decades on habituation of startle and other escape responses, the underlying neural mechanisms are still not fully understood. There is evidence from previous studies indicating that BK channels might play a critical role in habituation. We here used a wide array of approaches to test this hypothesis. We show that BK channel activation and subsequent phosphorylation of these channels are essential for synaptic depression presumably underlying startle habituation in rats, …

Bk Channels Mediate Synaptic Plasticity Underlying Habituation In Rats., Tariq Zaman, Cleusa De Oliveira, Mahabba Smoka, Chakravarthi Narla, Michael O Poulter, Susanne Schmid

Brain and Mind Institute Researchers' Publications

Habituation is a basic form of implicit learning and represents a sensory filter that is disrupted in autism, schizophrenia, and several other mental disorders. Despite extensive research in the past decades on habituation of startle and other escape responses, the underlying neural mechanisms are still not fully understood. There is evidence from previous studies indicating that BK channels might play a critical role in habituation. We here used a wide array of approaches to test this hypothesis. We show that BK channel activation and subsequent phosphorylation of these channels are essential for synaptic depression presumably underlying startle habituation in rats, …

Activity Of Distinct Growth Factor Receptor Network Components In Breast Tumors Uncovers Two Biologically Relevant Subtypes, Moom Roosan, Shelley M. Macneil, David F. Jenkins, Gajendra Shrestha, Sydney R. Wyatt, Jasmine A. Mcquerry, Stephen R. Piccolo, Laura M. Heiser, Joe W. Gray, W. Evan Johnson, Andrea H. Bild

Pharmacy Faculty Articles and Research

Background
The growth factor receptor network (GFRN) plays a significant role in driving key oncogenic processes. However, assessment of global GFRN activity is challenging due to complex crosstalk among GFRN components, or pathways, and the inability to study complex signaling networks in patient tumors. Here, pathway-specific genomic signatures were used to interrogate GFRN activity in breast tumors and the consequent phenotypic impact of GRFN activity patterns.

Methods
Novel pathway signatures were generated in human primary mammary epithelial cells by overexpressing key genes from GFRN pathways (HER2, IGF1R, AKT1, EGFR, KRAS (G12V), RAF1, BAD). The pathway analysis toolkit Adaptive Signature Selection …

Metformin To Augment Strength Training Effective Response In Seniors (Masters): Study Protocol For A Randomized Controlled Trial, Doug E. Long, Bailey D. Peck, Jenny L. Martz, S. Craig Tuggle, Heather M. Bush, Gerald Mcgwin, Philip A. Kern, Marcas M. Bamman, Charlotte A. Peterson

Clinical and Translational Science Faculty Publications

Background: Muscle mass and strength are strong determinants of a person's quality of life and functional independence with advancing age. While resistance training is the most effective intervention to combat age-associated muscle atrophy (sarcopenia), the ability of older adults to increase muscle mass and strength in response to training is blunted and highly variable. Thus, finding novel ways to complement resistance training to improve muscle response and ultimately quality of life among older individuals is critical. The purpose of this study is to determine whether a commonly prescribed medication called metformin can be repurposed to improve the response to resistance …

An Examination Of Medicinal Ethnobotany And Biomedicine Use In Two Villages On The Phnom Kulen Plateau, Taylor Walker

Undergraduate Research Awards

Cambodians address symptomatic illness in two ways: they use traditional medicine, including medicinal plants, and biomedicine. Despite various attempts to quantify medicinal ethnobotany in Cambodia, no national ethnopharmacopoeia exists, and there is a gap in the literature regarding the mechanisms through which traditional medicines are prepared and used. This report presents an examination of the ethnopharmacopoeia of two villages within Phnom Kulen National Park, a study site chosen for its unique ecology and status as one of Cambodia’s last remaining regions with lowland evergreen and semi-evergreen forest. The report also investigates the mechanisms through which villagers make decisions regarding illness …

Opinion: Inhibition Of Blood-Brain Barrier Repair As A Mechanism In Hiv-1 Disease., Monique E. Maubert, Brian Wigdahl, Michael R. Nonnemacher

Kimmel Cancer Center Papers, Presentations, and Grand Rounds

No abstract provided.

Qt Prolongation Is Associated With Increased Mortality In End Stage Liver Disease, Sun Moon Kim, Bennet George, Diego Alcivar-Franco, Charles L. Campbell, Richard Charnigo, Brian P. Delisle, Jonathan Hundley, Yousef Darrat, Gustavo Morales, Samy-Claude Elayi, Alison L. Bailey

Internal Medicine Faculty Publications

AIM

To determine the prevalence of QT prolongation in a large series of end stage liver disease (ESLD) patients and its association to clinical variables and mortality.

METHODS

The QT interval was measured and corrected for heart rate for each patient, with a prolonged QT cutoff defined as QT > 450 ms for males and QT > 470 ms for females. Multiple clinical variables were evaluated including sex, age, serum sodium, international normalized ratio, creatinine, total bilirubin, beta-blocker use, Model for End-Stage Liver Disease (MELD), MELD-Na, and etiology of liver disease.

RESULTS

Among 406 ESLD patients analyzed, 207 (51.0%) had QT prolongation. …

Metformin To Augment Strength Training Effective Response In Seniors (Masters): Study Protocol For A Randomized Controlled Trial, Douglas E. Long, Bailey D. Peck, Jenny L. Martz, S. Craig Tuggle, Heather M. Bush, Gerald Mcgwin, Philip A. Kern, Marcas M. Bamman, Charlotte A. Peterson

Physical Therapy Faculty Publications

Background: Muscle mass and strength are strong determinants of a person’s quality of life and functional independence with advancing age. While resistance training is the most effective intervention to combat age-associated muscle atrophy (sarcopenia), the ability of older adults to increase muscle mass and strength in response to training is blunted and highly variable. Thus, finding novel ways to complement resistance training to improve muscle response and ultimately quality of life among older individuals is critical. The purpose of this study is to determine whether a commonly prescribed medication called metformin can be repurposed to improve the response to resistance …

Optimization Of Fluorescent Imaging In The Operating Room Through Pulsed Acquisition And Gating To Ambient Background Cycling, Kristian J. Sexton, Yan Zhao, Scott C. Davis, Shudong Jiang, Brian Pogue

Dartmouth Scholarship

The design of fluorescence imaging instruments for surgical guidance is rapidly evolving, and a key issue is to efficiently capture signals with high ambient room lighting. Here, we introduce a novel time-gated approach to fluorescence imaging synchronizing acquisition to the 120 Hz light of the room, with pulsed LED excitation and gated ICCD detection. It is shown that under bright ambient room light this technique allows for the detection of physiologically relevant nanomolar fluorophore concentrations, and in particular reduces the light fluctuations present from the room lights, making low concentration measurements more reliable. This is particularly relevant for the light …

Camping For Children With Cerebral Palsy, Emily Scannell

Honors Theses

Children with cerebral palsy and their families may have needs that make camping difficult or seemingly inaccessible. Through an explanation of the research backing the benefits of camping, this paper makes it clear that camping is a worthwhile activity that can be optimized through modifications. Understanding cerebral palsy and the steps of basic camping activities, it is possible to create modifications to increase family and child wellness while camping. Through a hypothetical case study, a specific look can be had at the ways to prepare for an optimal camping experience- from adapted equipment, to modified preparatory strategies. Through a review …

Can Global Health Governance Contend With Transnational Corporate Activities? A Case Study On The Chinese Tobacco Industry, Xing Gao

Geography Honors Projects

In the past two decades, China’s state-owned tobacco enterprise (CNTC) has expanded its operation and influence abroad under the “going global” strategy. These globalization activities directly and indirectly impact the Framework Convention on Tobacco Control (FCTC), the first international treaty signed under the WHO auspices. In this project, I explore how certain CNTC expansionary strategies undermine FCTC articles, as well as the ways in which FCTC articles have failed to curb the tobacco industry’s transnational growth. Using international political economy as an overarching framework for the analysis of global health governance, I argue that the FCTC fails to halt the …