Medicine and Health Sciences Commons^™

Effect Of Cannabinoids On Osteogenic Differentiation Of Cultured Vascular Smooth Muscle Cells, Bree A. Eccles

Undergraduate Honors Theses

Vascular calcification is strongly correlated with the clinical manifestations of atherosclerosis, heart attacks and strokes. The calcification process resembles bone formation and involves the osteogenic trans-differentiation of smooth muscles cells within the arterial wall. Cannabinoid receptors are known to modulate bone formation and are present in atherosclerotic vessels, suggesting they may also play a role in modulating calcification. Therefore, we evaluated the effects of cannabinoids on the expression of osteogenic proteins by vascular smooth muscle cells undergoing calcification.

Toll Like Receptor 4 Stimulation Increases Scavenger Receptor A Expression On Murine Macrophages, Mackenzie L. Guthrie

Undergraduate Honors Theses

Sepsis is the body’s response to an overwhelming infection and is a serious consequence of critical illness. It can cause tissue damage, organ failure, and death. Sepsis continues to have an unacceptably high mortality rate, due to the lack of effective treatments. Specific therapeutic targets for sepsis remain elusive since the complex functional changes that result in a septic state remain poorly understood. Macrophage Scavenger Receptor A (SRA, CD204) is a surface receptor that binds negatively charged, endogenous and exogenous ligands. We have discovered that SRA plays a significant role in the pathophysiology of sepsis. We have shown that mice …

Determination Of The Effects That A Previously Uncharacterized Secreted Product From Klebsiella Pneumoniae Has On Citrobacter Freundii And Enterobacter Cloacae Biofilms, Cody M. Hastings

Undergraduate Honors Theses

More so than ever, Multiple Drug Resistant (MDR) bacteria are on the rise due to overuse of antibiotics along with natural selection for adaptations that enhance drug-resistant properties. One particular bacterial family, Enterobacteriaceae, has been problematic, exhibiting several bacterial members that have developed a precipitous resistance to modern antibiotics and are also primary causative agents of nosocomial, or hospital acquired, infections. Citrobacter freundii (CF) and Enterobacter cloacae (ECL) are two species of the Enterobacteriaceae family causing significant medical concern due to their role in producing numerous opportunistic infections such as bacteremia, lower respiratory tract infections, urinary tract infections, and endocarditis. …

Burn Wound Bacteria Susceptibility To A Novel Antimicrobial Compound, Bo H. Marshall

Undergraduate Honors Theses

A breach of the skin barrier, due to a burn wound, facilitates colonization by various microorganisms. Burn wounds can become colonized from the patients’ own skin flora, respiratory tract, or with exogenous bacteria from the environment. Strategies to treat burn wound infections are multipronged: removal of the infected necrotic tissue, wound dressing to protect the damaged area, and treatment with specific antimicrobials to prevent reinfection. The development of chronic infections, which could potentially lead to sepsis, depends largely on how well the microorganisms form biofilms within the wound. There are numerous antimicrobial gels and antibiotics that help prevent a burn …

Week Of May 1, 2017, New York Medical College

InTouch

• AOA Iota Chapter Celebrates Annual Lecture and Induction Banquet
• D.P.T. Class of 2017 Celebrates at Thirteenth Annual Doctoral Project Presentation Day
• NYMC Reflects on Yom Hashoah
• AMWA presents 2017 Gender Equity Faculty Award to Susan Rachlin, M.D.
• Turkeys Return to Campus

Sonoelastography Of The Common Flexor Tendon Of The Elbow With Histologic Agreement: A Cadaveric Study., Andrea S Klauser, Mathias J Pamminger, Ethan J. Halpern, Mohamed M H Abd Ellah, Bernhard Moriggl, Mihra S Taljanovic, Christian Deml, Judith Sztankay, Guenter Klima, Leonhard Gruber, Werner R Jaschke

Department of Radiology Faculty Papers

Purpose To determine the correlation of the results of conventional B-mode ultrasonography (US) and compression sonoelastography with histologic results in common flexor tendons of the elbow in human cadavers. Materials and Methods Twenty-five common flexor tendons were evaluated in 16 fresh, unembalmed cadavers of 11 women with a median age of 85 years (range, 71-101 years) and five men with a median age of 78 years (range, 70-88 years). Informed consent was provided according to the last will of the donors. B-mode US results were classified as grade 1, normal tendon with homogeneous fibrillar pattern; grade 2, tendon thickening or …

Temperament And Behavior Factors In A Community Sample Of Youth With Selective Mutism, Rachele Alexandra Diliberto

UNLV Theses, Dissertations, Professional Papers, and Capstones

Children with selective mutism often present as a very diverse population, with both oppositional (APA, 2013; Cohan et al., 2008; Steinhausen & Juzi, 1996), and anxious symptoms (APA, 2013; Kristensen, 2000; Vecchio & Kearney, 2009) most commonly reported. The first aim of the current study was to validate the presence of previously identified anxious and oppositional behavior factors in a community sample of youth with selective mutism. These factors were previously identified in a clinic sample of youth with selective mutism (Diliberto & Kearney, 2016). The second aim was to examine the association of anxious and oppositional behavior factors with …

Factors Influencing Induction Of Desiccation Tolerance In Bryophytes: Redefining Fundamental Aspects Of The Organism’S Relationship With The Environment In Xeric Habitats, Joshua Lee Greenwood

UNLV Theses, Dissertations, Professional Papers, and Capstones

If one wishes to understand the ecological role, range, habitat preferences, selective pressures, reproduction, response to climate change, and the potential for survival under climactic change, range expansion and range contraction for species and populations of bryophytes, an understanding of their survival of the desiccated state, is essential. In order to further our understanding of desiccation tolerance in mosses, three projects were undertaken. The first of these investigated the nature of desiccation tolerance in mosses, specifically if desiccation tolerance can be induced; thereby providing a desiccation tolerant phenotype in a moss species generally considered desiccation sensitive (Physcomitrella patens, the model …

The Reliability Of The Thoracic Percussion Test, Casey Donaldson, Rey Veloz, Kaylee Waters

UNLV Theses, Dissertations, Professional Papers, and Capstones

Objective: To investigate the reliability of the Thoracic Percussion Test (TPT), which is a quick screening tool used by manual therapists to assess hypomobility in the thoracic spine. Participants: 36 healthy subjects (18-60 years old), with or without back pain, and 10 therapists participated in the study. Six of the therapists with less than 5 years clinical experience were considered “novice” and 4 with at least 20 years experience were considered “expert” therapists. Methods: All participants were divided into a morning and an afternoon group. Both groups consisted of 18 subjects and a mix of novice and expert therapists. All …

Can Simple Postural Instructions Modify Running Forms In Recreational Runners, Casey Gray, Matthew Poggemiller, Ian Tracy

UNLV Theses, Dissertations, Professional Papers, and Capstones

Purpose/Hypothesis: Recent research suggests that alteration of trunk angle and foot strike pattern during running may result in beneficial changes that prevent running related injuries due to reduction in vertical ground reaction forces (vGRF). For example, running form emphasizing a forward trunk lean and a midfoot or forefoot strike pattern has been shown to be effective in reducing knee stress and the risks of other impact-related running injuries. In clinical practice however, it is currently unknown if simple postural cues given to runners can elicit motor learning that leads to modification of running form. The purpose of this study was …

High School Gardens Program Across The Nation: Current Practices, Perceived Benefits, Barriers, And Resources, Noehealani Cierra Bareng- Antolin

UNLV Theses, Dissertations, Professional Papers, and Capstones

School garden programs in the United States emerged near the end of the 19th century. The use and purpose of school gardens are multifaceted and is dependent on the school and individuals involved. Current research on school garden programs suggests positive benefits for student academic achievement, nutrition knowledge, and dietary behaviors. Research on school garden programs is predominately conducted at the elementary and middle school levels. High school garden programs do exist; however, there is limited research on the current practices, perceived benefits of, barriers to, and resources necessary for high school garden programs. The purpose of this study was …

Buspirone For The Treatment Of Dementia With Behavioral Disturbance, Maria R. Santa Cruz, Priscilla Hidalgo, Meredith Lee, Cornelius Thomas, Suzanne Holroyd

Psychiatry

Behavioral disturbances are common but serious symptoms in patients with dementia. Currently there are no FDA approved drugs for this purpose. There have been case reports and small case series of the use of buspirone. In this retrospective study, we review 179 patients prescribed buspirone for treatment of behavioral disturbance in dementia to better characterize the efficacy and potential side effects. All patients prescribed buspirone for behavioral disturbance due to dementia from a geropsychiatric outreach program were reviewed. Data was collected and analyzed using SPSS. One hundred-seventy-nine patients met criteria for the study with a mean age of 83.8 + …

Nature, Scope And Use Of Economic Evaluation Of Healthcare Programmes: With Special Reference To Pakistan., Muhammad Ashar Malik, Saleem Perwaiz Iqbal, Farina Abrejo

Community Health Sciences

Economic evaluation (EE)/cost effectiveness analysis(CEA) of healthcare programmes is an emerging area, yet the resource base to apprehend EE/CEA is very limited in Pakistan. This paper attempts to fill this gap by providing a basic text in the field of EE with special reference to Pakistan. We used four dimensional criteria (available, relevant, complete and accurate) for reviewing the EE contents in the locally available textbooks and reading material on public health. We find CEA as core competency and skill of medical doctors in undergraduate medical curricula yet we could not find EE contents in the recommended textbooks. We find …

Did Contracting Effect The Use Of Primary Health Care Units In Pakistan?, Ashar Muhammad Malik, Ellen Van De Poel, Eddy Van Doorslaer

Community Health Sciences

For many years, Pakistan has had a wide network of Basic Health Units spread across the country, but their utilization by the population in rural and peri-urban areas has remained low. As of 2004, in an attempt to improve the utilization and performance of these public primary healthcare facilities, the government has gradually started contracting-in intergovernmental organizations to manage these BHUs. Using five nationally representative household surveys conducted between 2001 and 2012, and exploiting the gradual roll-out of this reform to apply a difference-in-difference approach, we evaluate its impact on BHU utilization. We find that contracting of the BHU management …

Meaning Of Pregnancy Terms Among African-American Women, Stephanie Solomon, Sandra G. Suther, Ivette Lopez, Alicestine Ashford, Linda C. Amankwaa, Gareth Dutton

The Qualitative Report

The concept of pregnancy intendedness is complex and may not bear the same meaning to all women. Moreover, researcher definition and women’s meaning were thought to be different. Some researchers have indicated that it is unclear how well women understand and relate to questions used by the National Survey of Family Growth (NSFG) and how the classifications relate to women’s lives. The purpose of this study was to explore the meaning of terms such as planned and/or intended pregnancy among African-American women of childbearing age using a qualitative exploratory descriptive method. Although African-American women want children, they are three times …

Attitudes And Perceptions Of Advanced Practice Nurses Towards Health Information Technology And Its Effects On Caring, Debbie Ramos Shih

Doctoral Projects

Technology is rapidly, constantly evolving, and affecting healthcare. While it has the ability to improve healthcare outcomes, it is important to realize the impact this technology has on the relationships between patients and nurses (Korhonen, et al., 2015). Interactions with patients are increasing through computer technology and decreasing by physical presence and touch, potentially compromising the development of a trusting relationship and thus affecting patient quality outcomes (Sandelowski, 2002).

This cross sectional study explored the attitudes and perceptions of APRNs towards HIT and its effects on caring. 150 Advanced Practice Clinicians in a Northern California healthcare was surveyed, using the …

Preconception Care Of Women On Prescribed Opioids, Rebecca-Maria Norwick

Doctoral Projects

The landmark 2015 report from the Center for Disease Control (CDC) posited that too many women of reproductive age received prescribed opioids. This is significant because fetal exposure to a known teratogen can have catastrophic outcomes. Furthermore, women are often ambivalent about birth control and many pregnancies are unplanned. Fortunately, women identify interactions with health care providers as acceptable cues for preconception decision making. Data has shown that Medicaid populations are disproportionately prescribed opioids compared to insured populations. However, the CDC defines reproductive status by age only. Therefore, the purpose of this research project was to identify women’s actual risk …

An Assessment And Analysis Of The Complexity Of The Frontline Nurse Leaders' Role, Robert Alan Vos

Doctoral Projects

Purpose: The purpose of this research study is to identify frontline nurse leaders' perception of their role, to have them assess their skills in relationship to that role and to identify knowledge needs and gaps that they face in fulfilling their role.

Design: This doctoral research explored the role of the frontline nurse leader. The research was a quantitative survey, non-experimental, descriptive, cross-sectional onetime study. The survey studied the self-assessment of the frontline nurse leader's role and their rating of noted complexities and challenges in their role.

Methods: A survey tool was developed using thirty statements. The statements covered the …

An Assessment Of The Associate Degree Nursing Students’ Understanding Of Health Literacy Concepts When Providing Health Promotion For The Diabetic Patient, Donna L. Lebaron

Doctoral Projects

Health literacy (HL) concept deficiencies exist in undergraduate nursing curricula (Smith and Zsohar, 2011; Cornett, 2009; Jukkala, Deupree, Graham, 2009). As future nurses who will have a significant impact on client health literacy assessment, it is essential that health literacy-related content be integrated into undergraduate nursing educational curricula (Sand-Jecklin, Murray, Summers, Watson, 2010; McCleary-Jones, 2012). The prevalence of Type 2 diabetes (T2D) has significantly increased resulting in greater morbidity and mortality risks to the general public; therefore, programs for diabetes prevention, education, and health literacy assessments have become a national priority (Whittemore, Rosenberg, Gilmore, Withey, and Breault, 2013; Hemingway, Stephenson, …

The Influence A Multiple Teaching Modalities Course On Knowledge And Self-Confidence Of Newly Trained Emergency Nurses, Anna C. Montejano

Doctoral Projects

Many new graduate residency programs exist supporting new registered nurses (RN) transition from theory to practice, but what is not reported in the literature are programs for RNs transitioning in practice to specialty care units, such as the emergency department. Furthermore, literature addressing the use of multiple teaching modalities as a method in course work is limited. A quasi-experimental design study explored the influence a multiple teaching modalities course on the knowledge and self-confidence of newly trained emergency department nurses. Results indicated using multiple teaching modalities provided a benefit to newly trained ED nurses with an increase in knowledge and …

African American Men And Ostrich Behavior, Debbie Slack-Gay

Doctoral Projects

This project explores why African American men choose Ostrich Behavior when it comes to health care prevention and maintenance as related to hypertension. The population was African American men, ages18–80, in Northern California. Men were recruited while getting a haircut or waiting for one or after church services. Blood pressure readings were taken and a health questionnaire was administered. The results show that even if hypertension is known, men ages 18–45 go to fewer office visits than African American men in other age groups, and older men tend to seek medical care and take medication if prescribed.

Improving Patient Outcomes: Early Mobilization Of Intensive Care Patients, Casey Teves

Honors College Theses

Early mobilization of intensive care patients has gained the interest of researchers within the last few years due to its safe and practical application and numerous benefits it can provide. Reviewing the literature on this topic reveals the substantial benefits of early mobilization and the detrimental effects of prolonged bed-rest. Despite recent evidence proving that this practice will increase quality of care, many intensive care units still utilize bed-rest as a standard. Understanding the barriers and facilitators of this change can help transform this research into practice and improve patient care outcomes. Nurses are the key facilitators in the initiative …

Clinical Characteristics And Outcome Of Budd-Chiari Syndrome At A Tertiary Care Hospital In Pakistan., Om Parkash, Aysha Khan, Saeed Hamid

Section of Gastroenterology

OBJECTIVE: To determine the clinical characteristics of Budd-Chiari syndrome (BCS), its causes and outcome at a tertiary care hospital.

STUDY DESIGN: An observational study

.PLACE AND DURATION OF STUDY: The Aga Khan University Hospital,Karachi, from 2004 to 2014.

METHODOLOGY: Aretrospective analysis of data was conducted. Apredesigned questionnaire was filled from medical records of patients with BCS. Clinical features, etiology, management and outcome was noted from 2004 to 2014. Descriptive statistics were determined.

RESULTS: Forty-five patients' charts were reviewed; 26 (57.8%) were male patients. The median (IQR) age at diagnosis was 26.0 (20.5 to 34.5) years. Primary BCS was seen in …

Chemical And Structural Characterization Of A Model Post-Termination Complex (Potc) For The Ribosome Recycling Reaction: Evidence For The Release Of The Mrna By Rrf And Ef-G., Nobuhiro Iwakura, Takeshi Yokoyama, Fabio Quaglia, Kaoru Mitsuoka, Kazuhiro Mio, Hideki Shigematsu, Mikako Shirouzu, Akira Kaji, Hideko Kaji

Department of Biochemistry and Molecular Biology Faculty Papers

A model Post-Termination Complex (PoTC) used for the discovery of Ribosome Recycling Factor (RRF) was purified and characterized by cryo-electron microscopic analysis and biochemical methods. We established that the model PoTC has mostly one tRNA, at the P/E or P/P position, together with one mRNA. The structural studies were supported by the biochemical measurement of bound tRNA and mRNA. Using this substrate, we establish that the release of tRNA, release of mRNA and splitting of ribosomal subunits occur during the recycling reaction. Order of these events is tRNA release first followed by mRNA release and splitting almost simultaneously. Moreover, we …

Dysregulated Gpcr Signaling And Therapeutic Options In Uveal Melanoma., Vivian Chua, Dominic Lapadula, Clinita Randolph, Jeffrey L. Benovic, Philip B. Wedegaertner, Andrew E. Aplin

Department of Biochemistry and Molecular Biology Faculty Papers

Uveal melanoma is the most common primary intraocular malignant tumor in adults and arises from the transformation of melanocytes in the uveal tract. Even after treatment of the primary tumor, up to 50% of patients succumb to metastatic disease. The liver is the predominant organ of metastasis. There is an important need to provide effective treatment options for advanced stage uveal melanoma. To provide the preclinical basis for new treatments, it is important to understand the molecular underpinnings of the disease. Recent genomic studies have shown that mutations within components of G protein-coupled receptor (GPCR) signaling are early events associated …

Disc Golf As A Public Health Option: Utilizing America's Natural Resources To Offer Low Cost Outdoor Exercise, Victor Martins

Senior Theses

This paper explores the appeal and growth potential of disc golf as a way to offer a fun and immersive exercise experience. In a time when the United States is a world leader in obesity, understanding issues like appeal, exercise motivation and accessibility are important as the country looks to redirect itself towards a healthier future. In order to understand what brings disc golfers in, a survey of player motivations across demographic groups was completed using a rated average system. In doing so, researchers gained insight and verification of the game’s appeal under the framework of previous public health and …

Early Behavioral And Physiological Predictors Of Autism In 12-Month-Old Siblings Of Children With Autism, Nicolas Poupore

Senior Theses

This study included two primary objectives. First, we aimed to see if the ASIBs demonstrate atypical physiological regulation relative to low risk controls (LRCs) and if ASD behavioral risk markers are related to physiological regulation at 12 months of age. We hypothesized that the ASIBs will have atypical physiological control in both RSA and RSA suppression compared to the LRCs and that the behavioral ASD risk markers are correlated to these atypical physiological regulations. Second, we aimed to determine if physiological regulation differs in the ASIBs that do and do not end up with an ASD diagnosis, and if there …

Baaamm, Angela R. Miller, Alice Mary Thomas, Melissa Rivera, Brooke A. Pfaff, Ana Zuanic, Monica Esquivel

LMU Theses and Dissertations

BAAAMM was born in April 2016, when a group of six creative researcher-artists came together to investigate cultural identity through art making. Through searching, reaching, and wrestling, the group developed creative experiential processes by which to discover and communicate cultural identity through art and language. Over a few weeks, the creative researcher-artists generated a body of work expressing their unique cultural identities and felt responses to one another. This diverse collaborative wants to share their work to stimulate others to enter the realm of creativity, vulnerability, and receptivity to understand themselves better.

BAAAMM is an exploratory cultural happening exhibiting individual …

Disability: Becoming An Advocate For Persons With Disabilities And Understanding The History Of The Disability Movement In The United States, Frances Mason Ramsay

Senior Theses

The purpose of this thesis is to look at the different facets that make up disability in the United States, with a specific focus on the children with disabilities. These facets include related legislation, the education system, activism, services, and what it means to care for a child with disabilities. Throughout the research process, each of these facets were analyzed to include the most significant events for the section, an overview of each section to provide insight and a small amount of background and history for someone relatively unfamiliar with the history of disability in the United States. Beyond research …

The Pharmacognosy And Therapeutic Efficacy Of Turmeric (Curcuma Longa): A Systematic Review, Maghan Ballantyne

Senior Honors Projects

Turmeric is a well-known natural product, native to Southeast Asia, commonly

used for a variety of cultural traditions and health benefits. Generally referred

to as curcumin, it is a member of the Zingiberaceae, or ginger family, utilized

for its roots and known for its vibrant yellow hue. Culturally, it is primarily

incorporated into cooking and as an integral part of religious rituals and

ceremonies. Chemically, turmeric is classified as a phenolic compound, made

up of many curcuminoids, each with varying levels of activity. Therapeutically,

its health benefits include anti-inflammatory, anti-hyperlipidemia, anti-oxidant

and anti-pruritic properties. The pharmacognosy of curcumin modulates

inflammatory …