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2017 Peter Morgane Student Research Fellowship, University Of New England College Of Osteopathic Medicine

Peter Morgane Research Fellowships

2017 recipients of the University of New England College of Osteopathic Medicine's Peter Morgane Research Fellowship.

Effects Of Sodium-Glucose Cotransporter 2 Inhibitors On 24-Hour Ambulatory Blood Pressure: A Systematic Review And Meta-Analysis, William L. Baker, Leo F. Buckley, Michael S. Kelly, John D. Bucheit, Eric D. Parod, Roy Brown, Salvatore Carbone, Antonio Abbate, Dave L. Dixon

Pharmacy Faculty Articles and Research

Background-—Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a novel class of antihyperglycemic agents that improve glycemic control by increasing glycosuria. Additional benefits beyond glucose lowering include significant improvements in seated clinic blood pressure (BP), partly attributed to their diuretic-like actions. Less known are the effects of this class on 24-hour ambulatory BP, which is a better predictor of cardiovascular risk than seated clinic BP.

Methods and Results-—We performed a meta-analysis of randomized, double-blind, placebo-controlled trials to investigate the effects of SGLT2 inhibitors on 24-hour ambulatory BP. We searched all studies published before August 17, 2016, which reported 24-hour ambulatory …

Defining Outcome Measures For Psoriatic Arthritis: A Report From The Grappa-Omeract Working Group., Alexis Ogdie, Maarten De Wit, Kristina Callis Duffin, Willemina Campbell, Jeffrey Chau, Laura C Coates, Lihi Eder, Musaab Elmamoun, Oliver Fitzgerald, Dafna D Gladman, Niti Goel, Jana James, Umut Kalyoncu, John Latella, Chris Lindsay, Philip Mease, Denis O'Sullivan, Ingrid Steinkoenig, Vibeke Strand, William Tillett, Ana-Maria Orbai

Articles, Abstracts, and Reports

The Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA)-Outcome Measures in Rheumatology (OMERACT) Psoriatic Arthritis (PsA) Core Set working group recently published the updated 2016 psoriatic arthritis (PsA) core domain set, a set of disease features that should be measured in all clinical trials. At the GRAPPA annual meeting in July 2016, the PsA working group presented the updated PsA core domain set endorsed by 90% of participants at OMERACT in May 2016 and drafted a roadmap for the development of the PsA core outcome measurement set. In this manuscript, we review the development process of the …

Restriction Spectrum Imaging Improves Risk Stratification In Patients With Glioblastoma., A P Krishnan, R Karunamuni, K M Leyden, T M Seibert, R L Delfanti, J M Kuperman, H Bartsch, P Elbe, A Srikant, A M Dale, Santosh Kesari, D E Piccioni, J A Hattangadi-Gluth, N Farid, C R Mcdonald, N S White

Articles, Abstracts, and Reports

BACKGROUND AND PURPOSE: ADC as a marker of tumor cellularity has been promising for evaluating the response to therapy in patients with glioblastoma but does not successfully stratify patients according to outcomes, especially in the upfront setting. Here we investigate whether restriction spectrum imaging, an advanced diffusion imaging model, performed after an operation but before radiation therapy, could improve risk stratification in patients with newly diagnosed glioblastoma relative to ADC.

MATERIALS AND METHODS: Pre-radiation therapy diffusion-weighted and structural imaging of 40 patients with glioblastoma were examined retrospectively. Restriction spectrum imaging and ADC-based hypercellularity volume fraction (restriction spectrum imaging-FLAIR volume fraction, …

Optical Imaging Of Metabolic Adaptability As A Biomarker For Metastatic Potential In Breast Cancer Cells, Mason G. Harper

Biomedical Engineering Undergraduate Honors Theses

Breast cancer metastasis is the main cause for mortality in breast cancer patients. However, knowledge of metastatic recurrence is limited, and there is a need to understand metastatic recurrence in order to treat breast cancer patients more effectively. Highly invasive metastatic breast cancer has shown to exhibit metabolic adaptability, transitioning from glycolysis to oxidative phosphorylation in the presence of microenvironmental stress. NADH and FAD are naturally occurring cofactor products during glycolysis and oxidative phosphorylation, respectively, and they are of particular importance during these metabolic processes due to their endogenous fluorescence. Measuring the ratio of fluorescence intensities of these cofactors through …

The Experience Of Illness In The Daily Lives Of Persons Living With Being Chronically Homeless, William Henderson

Nursing Dissertations - Archive

Individuals from all segments of society are affected by homelessness – the old and young, men and women, single individuals and families. The majority of individuals will experience homelessness only on a short-termed basis. However, about 10-20% will experience homelessness for years. Although, the chronically homeless represent only a fraction of the total homeless population, they utilize the majority of resources available. Current literature has focused primarily on other groups within the homeless community, leaving little to be known about the chronic homeless. Without a better understanding of this unique group, interventions can only be based upon assumptions. The purpose …

New Graduate Nurses And Transition To Practice, Regina Wilder Urban

Nursing Dissertations - Archive

A widely acknowledged transition to practice gap exists for nursing students who have recently graduated and are starting their first job as a registered nurse (RN). In an attempt to bridge this gap, new graduate nurses (NGNs) working in acute care hospitals are usually offered additional training in unit-specific knowledge and skills, along with time working with a unit-based preceptor. Hospital-based training programs are typically between two and six months in length, but the transition to becoming a competent RN with experience is estimated to take between 12 to 18 months (Duchscher, 2008). NGNs have much to learn and they …

Psychosocial Predictors Of Healthy Infant Birth Outcomes In Childbearing Women, Deana J. Furr

Nursing Dissertations - Archive

Low infant birth weight is a persistent problem in the United States. Psychosocial protective factors may confer benefits to vulnerable women, resulting in increased likelihood of healthy infant birth weight (HIBW). Few studies have examined predictors or correlates of healthy birth outcomes. The purpose of this study was to increase knowledge of protective factors and predictors of HIBW among childbearing women. A secondary analysis of the Fragile Families and Child Wellbeing Study public use baseline maternal surveys (1998 – 2000) was conducted (N = 4,759). Main predictors of HIBW were being married (adjusted odds ratio (OR) 2.38, 90% CI 1.12, …

Serious Infectious Events Following Cesarean Section, Janet Burton Glowicz

Nursing Dissertations - Archive

The purpose of this study was to evaluate trends in the incidence of serious infectious events (SIE), defined as organ space infection, sepsis, and Cesarean Section (CS) wound disruption, during the birth admission or resulting in between January 1, 2009 and December 31, 2014 in the State of Texas. A retrospective analysis of the Public Use Data File, maintained by the Texas Health Care Information Collection was conducted. Records of 627,555 women who had CS and 1,023 women readmitted for CS wound disruption, were included. During the study period, there was a large decrease in the rate at which SIE …

Formation Of Professional Identity And Everyday Ethical Comportment In Pre-Licensure Baccalaureate Nursing Students: A Grounded Theory Approach, Kristen D. Priddy

Nursing Dissertations - Archive

Formation of professional identity in nursing students is a necessary prerequisite to skilled, ethical, expert nursing practice. Nurses who have not formed an ethical professional identity have a negative impact on the workplace environment and the quality of patient care. These consequences have led educators in medicine and nursing to reconsider the importance of teaching for formation of professional identity and of helping students learn the skills of everyday ethical comportment. Nursing educators lay the foundation for professional nursing identity formation that continues when new graduate nurses enter practice. However, contemporary nursing curricula lack deliberate attention to the formation of …

A1c Reduction And Weight Loss In A Veteran Population Using Glp-1-Ras, Shelby L. Beutel Darrow

Undergraduate Honors Thesis Collection

Background: Diabetes mellitus is a metabolic disorder defined by high blood glucose. Glucagon-like peptide-1 receptor agonists (GLP-1-RAs) are a newer class of medications that offer potential 2 to 3 kg weight loss and a 1% to 1.5% decrease in A1c. At the Indianapolis Veterans Affairs Medical Center (VAMC), GLP-1-RAs are non-formulary.

Objectives: Primary outcomes included mean change in weight, body mass index (BMI) and A1c in VAMC patients. Secondary outcomes included the comparison to published values, analysis of insulin needs, and analysis of GLP-1-RA discontinuation reasons.

Methods: Indianapolis VAMC patients ages 18-80 with type 2 diabetes who started a GLP-1-RA …

“Cultures As Toolboxes”: An Introduction To The Special Issue Focused On Stem, Anita L. Bright

Journal of Multicultural Affairs

The Journal of Multicultural Affairs welcomes Dr. Anita Bright as a guest editor to lead a special issue on Science, Engineering, Technology, and Mathematics (STEM). Dr. Bright centers this special issue around one particularly simple, yet complex question, Is the teaching of science, technology, engineering, and mathematics multicultural?

When Teachers Get It Right: Voices Of Black Girls’ Informal Stem Learning Experiences, Natalie S. King

Journal of Multicultural Affairs

This paper is a part of a larger research study exploring the STEM learning experiences of Black girls who participated in an informal STEM program – I AM STEM. Through the process of reflection and co-construction of counterstories, Black girls reclaimed authorship of their lives. They identified three major attributes of teachers who promoted their academic success and engagement in STEM learning as ones who (a) responded to their needs and built a community of learners, (b) interacted with their parents in a professional manner, and (c) encouraged them to think critically and creatively during the lessons. Excerpts of their …

Chronotype, Class Times, And Academic Achievement Of University Students, Tristan Enright, Roberto Refinetti

Psychological Sciences Faculty Publications and Presentations

Numerous studies over the years have documented an effect of human chronotypes on physiological and psychological processes. Studies evaluating the impact of an individual’s chronotype on his/her academic achievement have indicated that morning chronotypes have an academic advantage over evening chronotypes. However, these studies did not account for the time of day in which the participants were being evaluated. The goal of the present study was to examine whether morning chronotypes do have an academic advantage over evening chronotypes when the time-of-day of classes and exams is taken into consideration. We obtained morningness-eveningness scores and course grades from 207 university …

Effects Of A Carbohydrate And Protein Recovery Beverage On Performance In Trained Weightlifters, Christopher B. Taber, Brad H. Deweese, Kimitake Soto, Charles A. Stuart, Michael H. Stone

All PTHMS Faculty Publications

INTRODUCTION: Previous investigations have examined nutrient timing with untrained subject and less is known about effects in trained subjects.

OBJECTIVES: The purpose of this study was to examine the effects of a carbohydrate and protein supplement (CHO+PROT) on performance measures in trained weightlifters.

METHODS: 10 trained weightlifters (30.8±5.1 years, 177.4 ±4.0 cm, 94.3 ± 12.4 kg, training age = 5.3 ± 2.9 years) completed a 12 week training program utilizing block periodization. Using a double blind placebo design, jump height, scaled peak power measured in vertical jumps and peak force and rate of force development measured in isometric mid-thigh pulls …

What’S New With The Flu?, Boriana Marintcheva

Bridgewater Review

No abstract provided.

Provider Based Interventions To Mitigate Risk For Opioid Pain Medication Abuse Among Adult Patients In A Primary Care Setting, Sheree Lamara Conley-Donaldson

Doctoral Projects

Mental and substance use disorders are predicted to exceed all physical disease processes causing major disability by 2020. Misuse and overdose of opioid pain medications is a significant public health concern in the United States. Approximately 1 in 4 patients receiving prescription opioids in primary care settings struggle with misuse. Half of all opioid prescriptions are written by primary care providers, including nurse practitioners. The purpose of this DNP project was to determine if nurse practitioner providers are implementing evidence-based practice guidelines including screening, brief intervention, and referral to treatment (SBIRT) to mitigate risk of prescription opioid pain medication misuse …

The Development And Validation Of A Resource Kit For Use By Ngos Pertaining To The Inclusion Of People With Disabilities In Sport-Based Programmes In Developing Countries, Koffi Atitso Fiati

Theses

The current study is undertaken in relation to the recommendations of both Article 30 of the United Nations Convention on the Rights of People with Disabilities-UNCRPD, (UN, 2006) and the new Charter on Physical Education, Physical Activity and Sport (UNESCO, 2015) to serve as a building block in the improvement of the health of people with disabilities (PWDs).

The study adopted a three-phase sequential mixed method approach with a participatory action research orientation. There was a document analysis, a survey, and interviews. The first phase comprised an analysis of four documents labelled as inclusive sport and physical activities resource kits. …

Euglycemic Dka In Mody Patient: Empagliflozin To Blame., Angela Magdaleno, Sandhya Venkataraman Do, Gretchen Perilli Md

Department of Medicine

No abstract provided.

Detection Of Leukocytes Stained With Acridine Orange Using Unique Spectral Features Acquired From An Image-Based Spectrometer, Courtney J. Hunter

Biomedical Engineering Undergraduate Honors Theses

A leukocyte differential count can be used to diagnosis a myriad blood disorders, such as infections, allergies, and efficacy of disease treatments. In recent years, attention has been focused on developing point-of-care (POC) systems to provide this test in global health settings. Acridine orange (AO) is an amphipathic, vital dye that intercalates leukocyte nucleic acids and acidic vesicles. It has been utilized by POC systems to identify the three main leukocyte subtypes: granulocytes, monocytes, and lymphocytes. Subtypes of leukocytes can be characterized using a fluorescence microscope, where the AO has a 450 nm excitation wavelength and has two peak emission …

Validation Of The Medication Box Task Assessment, Katherine Blank, Alison Chandler, Malcolm Isely, Serena Soria, Yamin Zaw

Dissertations, Masters Theses, Capstones, and Culminating Projects

There are a limited number of validated occupation-based cognitive assessments that are feasible in clinical settings. For individuals with acquired brain injury (ABI), ecologically valid cognitive assessments are needed to understand how cognition influences functional performance. This study implemented a quantitative exploratory correlational design using a battery of gold standard tabletop cognitive assessments as criterion measurements against the Medication Box Task assessment, an occupation-based cognitive assessment. Eight participants completed the test battery. The student researchers used Pearson correlations to analyze each participant’s scores on the Medication Box Task assessment and the scores on the battery of gold standard assessments. Results …

Fall Risk Reduction Using Lifestyle-Integrated Functional Exercise (Life), Kayla L. Comer, Tiffany Huang, Kelly Schmidt, Matthew W. Tong

Dissertations, Masters Theses, Capstones, and Culminating Projects

As the population and longevity of older adults’ increases, the prevalence of falls is becoming an ever-growing issue. Falls in older adults may lead to sedentary behavior, decreased independence, and lower quality of life. Evidence has shown that traditional exercise programs emphasizing strength and balance can decrease the fall risk in older adults, but may be difficult to sustain over time. Emerging evidence suggests that exercises that are integrated into daily life, as seen in the Lifestyle-integrated Functional Exercise (LiFE) program, may have a more lasting effect in reducing fall risk in older adults. This study explored the effectiveness of …

Novel Effects Of Prefoldin Pathway On Intestinal Homeostasis Via Dietary Restriction In Drosophila Melanogaster, Jesse Simons

Dissertations, Masters Theses, Capstones, and Culminating Projects

The field of medicine research is embroiled in a battle against aging. Particular focus is on the extension of lifespan and health-span. Lifespan duration is affected by many factors, one of which is the maintenance of the intestines of the organism. Homeostasis of the intestines is controlled by the regulation of intestine cell apoptosis and intestine cell proliferation. My research explores the role of two protein subunits found in a complex which may have possible functions in the regulation of these processes. The overall complex is formed from six subunit proteins, some of which are known to assist in other …

The Role Of Advanced Glycation End Products (Ages) Through The Trpa-1/Nrf-2 Activation Pathway In The Neurodegenerative Diseases, Sana Khateeb

Dissertations, Masters Theses, Capstones, and Culminating Projects

The posttranslational modification of macromolecules caused by highly reactive and toxic α-dicarbonyls, such as methylglyoxal (MGO) derived from glycolysis, is associated with various age-related diseases including diabetic complications and neurodegenerative diseases. Aging and long-term hyperglycemia causes enhanced production of this highly reactive α-dicarbonyl, which reacts with macromolecules causing irreversible damage of DNA and protein promoting the formation of advanced glycation end products (AGEs). The formation and accumulation of AGEs in different cell types affect intracellular and extracellular structure and function. AGEs can also cause macrovascular and microvascular complications through the formation of cross-links between key molecules, permanently altering cellular structure …

A Multiparous Woman With Lately Diagnosed Multilevel Left Ventricular Obstruction, Nasir Rahman, Ibrahim Gul, Amjad Nabi

Section of Cardiology

A 56-year hypertensive, multiparous woman presented to the cardiology unit with Canadian Cardiovascular Society (CCS) class-III angina and worsening dyspnea for the past few weeks. Her clinical examination showed high blood pressure and mid-systolic crescendo-decrescendo murmur radiating to carotids. However, there was no radio-femoral delay or significant blood pressure difference between her arms. Her transthoracic echocardiography (TTE) revealed moderate aortic stenosis (AS) and mid cavity left ventricular outflow (LVO) obstruction. Left heart catheterization (LHC) showed coarctation of aorta with extensive collaterals, mid cavity LVO obstruction, and moderate AS. Thus, she was diagnosed as a case of multi-level LVO obstruction including …

Factors Influencing Attendance, Postpartum Follow-Up, And Contraceptive Usage Among Teenage Centeringpregnancy® Participants, Latia Hickerson

Dissertations and Theses (Open Access)

Background: Teenage mothers are less likely to obtain postpartum examinations and contraception, increasing risks for negative social and health outcomes. The CenteringPregnancy® prenatal care model has been found to improve outcomes. However, little is known about factors influencing CenteringPregnancy® attendance or how this attendance impacts future pregnancy rates among teenagers.

Aim: The purpose of this study was to explore the association between CenteringPregnancy® attendance, postpartum return, contraception initiation and method selection. Additionally, the Group Care and Perinatal Behaviors Framework was used to assess the association between food insecurity, housing insecurity, intimate partner violence relationship status, partner group attendance and total …

In Pursuit Of Quality Research: Editors' Perspective, Jamshed Akhtar, Saba Sohail

Department of Radiology

No abstract provided.

“To Reduce Or Not Reduce: Is That A Question?”, Derek A. Woessner Md, Faafp, Christina Goral Ms, Atc

Department of Family Medicine

No abstract provided.

Identification Of Intrahelical Bifurcated H‑Bonds As A New Type Of Gate In K+ Channels, Oliver Rauh, Martin Urban, Leonhard M. Henkes, Tobias Winterstein, Timo Greiner, James L. Van Etten, Anna Moroni, Stefan M. Kast, Gerhard Thiel, Indra Schroeder

James Van Etten Publications

Gating of ion channels is based on structural transitions between open and closed states. To uncover the chemical basis of individual gates, we performed a comparative experimental and computational analysis between two K⁺ channels, Kcv_S and Kcv_NTS. These small viral encoded K+ channel proteins, with a monomer size of only 82 amino acids, resemble the pore module of all complex K+ channels in terms of structure and function. Even though both proteins share about 90% amino acid sequence identity, they exhibit different open probabilities with ca. 90% in Kcv_NTS and 40% in Kcv_S. …

Application Of Fluoroquinolone Resistance Score In Management Of Complicated Urinary Tract Infections, Ansal Shah, Julie Ann Justo, P Brandon Bookstaver, Joseph Kohn, Helmut Albrecht, Majdi N. Al-Hasan

Faculty Publications

The fluoroquinolone resistance score (FQRS) predicts the probability of fluoroquinolone resistance with good discrimination. The score has been derived from patients with bloodstream infections caused by Gram-negative bacteria and is based on fluoroquinolone use within the past 6 months, among other clinical and health care exposure criteria. This study aims to examine the utility of the FQRS in patients with complicated urinary tract infections (cUTI) and determine whether extension of prior fluoroquinolone use to 12 months improves model discrimination. Adults with cUTI at Palmetto Health in central South Carolina, USA, from 1 April 2015 through 31 July 2015 were prospectively …