Medicine and Health Sciences Commons^™

Environmental Health, Tessa Oliaro

Student Scholar Symposium Abstracts and Posters

There is a very important intersection between the environment, public health, and socioeconomic factors (Braveman, 2014). These include waste disposal, water use and quality, road safety, ecosystem services, and many more. Environmental health stresses, “the health impacts of physical, chemical, and biological agents in the environment and workplace, and learns to develop strategies to measure and control major environmental health problems both locally…and in settings around the globe” (UC Berkeley School of Public Health, 2017). This overarching umbrella can have emphases in environmental epidemiology, exposure science, climate change, ergonomics, home and industrial hygiene, and molecular epidemiology. Exploring each of these …

Structure Activity Relationship Studies Of Novel Diarylpentanoid Analogs Targeting The Androgen Receptor In Prostate Cancer Cells, Haili Coffin, Marco Bisoffi

Student Scholar Symposium Abstracts and Posters

The development of prostate cancer (PCa) relies strongly on the activation of the androgen receptor (AR) signaling pathway by its natural ligand dihydrotestosterone. Furthermore, PCa progression to metastatic disease represents oncogene addiction to AR activity. Androgen ablation therapy is thus a mainstay therapy against this disease, but the development of ligand-independent AR activation and persisting AR expression eventually leads to castration resistant PCa (CRPC). Therefore, down-regulation of AR expression in PCa cells may be an effective therapeutic modality. The diarylpentanoid ca27 has previously been shown to down-regulate AR expression by an unknown mechanism of action. The present work represents a …

The Use Of Emg As A Physical Therapy Learning Aid, Madeline L. Johnson, Rachel C. Cooklin, Erika N. Faria, Taylor M. Schavo, Eric Sternlicht

Student Scholar Symposium Abstracts and Posters

The purpose of this study was to compare the muscle recruitment of an agonist and antagonist muscle during the step up physical therapy exercise with and without visual electromyographic (EMG) biofeedback. 15 healthy, college-aged subjects were recruited to participate in the study. Subjects performed the step up with and without visual feedback in two separate sessions over a four week period. Muscle activity was recorded from the Vastus Medialis (VMO) of the target leg and Medial Gastrocnemius on the contralateral leg. EMG recordings were collected using a BTS FREEEMG system and data was processed using BTS SEMGanalyzer software (BTS Bioengineering, …

Efficacy Of Electromyography And The Dead Bug Exercise, Taylor M. Scavo, Rachel C. Cooklin, Erika N. Faria, Madeline L. Johnson, Eric Sternlicht

Student Scholar Symposium Abstracts and Posters

The Dead Bug exercise is performed in physical therapy clinics to restore lumbar spine stability and core strength in patients with lower back pain (LBP). The aim of this study was to evaluate the efficacy of using electromyography (EMG) feedback to enhance proper mechanics during the Dead Bug exercise. Sixteen healthy, college age students volunteered as subjects for the study. Subjects performed the Dead Bug (Fig. 1a.) with and without visual EMG cues and were given instructions on how to execute the exercise. Data was recorded using a BTS FREEEMG Analyzer and signal processed and data analyzed using the BTS …

Implementation Of An Evidence-Based Process For The Management Of Concussions In Adolescent Patients For A Primary Care Office, Ashley D. Karczewski

Doctoral Projects

The number of recreation and sports-related concussions (SRC) are estimated at 3.8 million every year in the United States. Recently, widespread media attention has been paid to concussion, and with this there has been a rise in adolescents with SRC seeking health care. Primary care providers are often the first to evaluate and provide treatment for adolescents with concussion. Despite the abundance of literature on concussions, there has been little empirical data to support management practices for this patient population. The purpose of the project was to provide an evidence-based process along with a clinical decision support tool to the …

Implementing A Two Class System For Monitoring Risk Indicators For Delayed-Onset Hearing Loss, Jessica Renee Stich-Hennen, Gabriel Anne Bargen

Journal of Early Hearing Detection and Intervention

Purpose: This manuscript discusses the importance of establishing risk indicator monitoring guidelines for state Early Hearing Detection and Intervention programs.

Method: Idaho Sound Beginnings (ISB) implemented a guideline which divided risk indicators associated with delayed-onset hearing loss into two classes (Class A and Class B). From 2012-2013, the incidence of delayed-onset hearing loss in the presence of Class A and Class B risk indicators were evaluated. For Class B risk indicators, ototoxic medication exposure and family history were analyzed.

Results: Of the 10,634 infants born, 1,175 were found to have passed the newborn hearing screening and have at least one …

Hearing And Vision Screening In Pediatric Primary Care And The Sharing Of Results With Early Care And Education Programs, Susan J. Macary, Lisa Honigfeld, Margaret W. Berry, Dorothy B. Wakefield

Journal of Early Hearing Detection and Intervention

This study explores the extent to which pediatric primary care (PPC) providers share hearing and vision screening results with early care and education (ECE) programs and report being unable to assess hearing and vision among pre-kindergarten children. Reports of hearing and vision screening are assessed to explore whether national support for early hearing detection and intervention has similarly promoted vision screening in PPC. We evaluated the reporting of hearing and vision screening data from 4,119 Early Childhood Health Assessment records, which were obtained from licensed ECE programs in Connecticut. Records were stratified by age group into younger or older per …

Information Given To Parents Of Neonatal-Intensive Care Unit Graduates On Hearing, Cydney E. Gehring, Alisha L. Jones

Journal of Early Hearing Detection and Intervention

Preterm infants and neonatal intensive care unit (NICU) graduates are more likely to have risk factors associated with hearing loss than their full-term, healthy peers, making them more prone to experience hearing loss (Behrman & Butler, 2007). This study examined information presented to parents during and after the newborn hearing screening (NBHS). A 22 question survey was posted on NICU and preemie support websites for parents to access and participate in anonymously. Results of the survey were analyzed for respondents indicating that their child was born in the year 2007 to the present. Thirty-nine percent of responding parents were unaware …

Audiology Students’ Perception Of Hybrid Simulation Experiences: Qualitative Evaluation Of Debriefing Sessions, Ahmad A. Alanazi, Nannette Nicholson, Samuel R. Atcherson, Clifford A. Franklin, Naveen K. Nagaraj, Michael Anders, Laura Smith-Olinde

Journal of Early Hearing Detection and Intervention

Simulation-based research is still new in the audiology field and requires more research to better understand students’ perspectives on standardized patients/parents (SPs) and manikins use. There is also limited research about debriefing practices in audiology. This qualitative study used a baby simulator and SPs to evaluate audiology students’ reflection during three debriefing sessions conducted at the University of Arkansas for Medical Science (UAMS) Simulation Center. Seventeen Doctor of Audiology (AuD) students participated in the simulation event, and the data were collected using the transcripts of videotaped debriefing sessions. The qualitative content analysis of the transcripts revealed eight sub-themes: support, compassion, …

The Role And Mechanism Of Erythrocyte Invasion By Francisella Tularensis, Deanna M. Schmitt, Rebecca Barnes, Taylor Rogerson, Ashley Haught, Leanne K. Mazzella, Matthew Ford, Tricia Gilson, James W.-M. Birch, Anders Sjöstedt, Douglas S. Reed, Jonathan M. Franks, Donna B. Stolz, James Denvir, Jun Fan, Swanthana Rekulapally, Donald A. Primerano, Joseph Horzempa

Biochemistry and Microbiology

Francisella tularensis is an extremely virulent bacterium that can be transmitted naturally by blood sucking arthropods. During mammalian infection, F. tularensis infects numerous types of host cells, including erythrocytes. As erythrocytes do not undergo phagocytosis or endocytosis, it remains unknown how F. tularensisinvades these cells. Furthermore, the consequence of inhabiting the intracellular space of red blood cells (RBCs) has not been determined. Here, we provide evidence indicating that residing within an erythrocyte enhances the ability of F. tularensis to colonize ticks following a blood meal. Erythrocyte residence protected F. tularensis from a low pH environment similar to that of …

Does A Voice Disorder Exist In Individuals With Cystic Fibrosis?, Jacquelyn Gadsby

Honors Program Theses and Projects

Cystic Fibrosis (CF) is a genetic disease of the exocrine gland (Gardner, 2007). The disease is characterized by thick secretion in organs (Lorenco, Costa and da Silva Filho, 2014). Chronic coughing can also be seen due to the thick secretions accumulating (Gardner, 2007). The transmembrane regulator gene is responsible for encoding an epithelial chloride channel (Lorenco, Costa and da Silva Filho, 2014).Thick viscous secretions through the respiratory tract and other organs, occur because the channel does not properly transport chloride and sodium to the epithelial membranes (Lorenco, Costa and da Silva Filho, 2014). The secretion in the respiratory system leads …

Hippotherapy: An Alternative Treatment From The Perceptions Of Practitioners, Leah Tinkham

Honors Program Theses and Projects

Hippotherapy can be defined as a dynamic service offered by occupational, physical, and speech-language pathologists that utilizes a horse’s unique movement to achieve functional outcomes. While there are an abundance of studies demonstrating the effectiveness of hippotherapy, very few have examined the perceptions of the practitioners. The purposes of this thesis are to investigate hippotherapy’s effectiveness as well as to examine the beliefs and attitudes towards hippotherapy use among occupational therapists, physical therapists, and speech therapists. A literature review was conducted to examine the effectiveness of hippotherapy.

The study included a total of 15 occupational, physical, and speech-language therapists who …

A Case For An Injury Prevention And Self-Care Program For Bridgewater State University’S Department Of Dance, Meghan Stanton

Honors Program Theses and Projects

Dancers are a unique kind of athlete, who blend athletic ability and artistic expression into their physical performance. Researchers are beginning to see the need for dancers to have access to rehabilitation and injury prevention programs like most collegiate sports athletes. This project researched and created a case for an injury prevention and self-care program to be implemented at Bridgewater State University. The research examined articles and books on different on-site dance medicine programs and the roles of athletic trainers with dancers, communicated with a current health care provider at Body Dynamics Inc., Jenna Calo, Boston University’s dance director, Micki …

A Variant Pfcrt Isoform Can Contribute To Plasmodium Falciparum Resistance To The First-Line Partner Drug Piperaquine, Satish K. Dhingra, Devasha Redhi, Jill M. Combrinck, Tomas Yeo, John Okombo, Philipp P. Henrich, Ann N. Cowell, Purva Gupta, Matthew L. Stegman, Jonathan M. Hoke, Roland A. Cooper, Elizabeth Winzeler, Sachel Mok, Timothy J. Egan, David A. Fidock

Collected Faculty Scholarship

Current efforts to reduce the global burden of malaria are threatened by the rapid spread throughout Asia of Plasmodium falciparum resistance to artemisininbased combination therapies, which includes increasing rates of clinical failure with dihydroartemisinin plus piperaquine (PPQ) in Cambodia. Using zinc finger nucleasebased gene editing, we report that addition of the C101F mutation to the chloroquine (CQ) resistance-conferring PfCRT Dd2 isoform common to Asia can confer PPQ resistance to cultured parasites. Resistance was demonstrated as significantly higher PPQ concentrations causing 90% inhibition of parasite growth (IC90) or 50% parasite killing (50% lethal dose [LD50]). This mutation also reversed Dd2-mediated CQ …

Pharmacological Threat To Lungs: A Case Series And Literature Review, Omar Irfan, Jaleed A. Gilani, Abeel Irshad, Babar Irfan, Javaid A. Khan

Section of Pulmonary & Critical Care

Drug-induced organ damage stands as a prevalent yet much-neglected issue globally. Keeping in view it's rising frequency, health care providers stand obliged to be well versed with the de-merits of the agents they prescribe. Drug therapies causing damage present with a non-specific clinical presentation, histological findings or radiology, which further elaborates on the necessity of a conscientious diagnosis. Pulmonary architecture ranging from the airways, lung parenchyma, mediastinum, pleura, pulmonary vasculature or the neuromuscular system, all can fall victim to the dreaded outcomes of this menace. In order to establish successful diagnosis, the definite temporal relation between initiation of drug therapy …

Equine Disease Model For Herpesvirus Neurologic Disease And Uses Thereof, George P. Allen, Glenda Ross

Veterinary Science Faculty Patents

Disclosed is an in vivo equine disease model and a method of preparing the disease model for equine herpesvirus-1 neurological disease comprising a horse having a low preexposure level of herpesvirus-specific CTL precursors wherein the horse is experimentally infected with a neuropathogenic strain of equine herpesvirus or a mutant thereof. Also disclosed is a method of quantifying the risk factors and predicting the development of clinical neurologic signs of equine herpesvirus-1 neurological disease in a horse. Also described in the invention is the determination of the risk of developing the clinical neurologic signs by a mathematical equation. A new live, …

03-07-2017 Hsc Committee Meeting Minutes, Patrice Martin

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

Ccr4 Is A Determinant Of Melanoma Brain Metastasis., Anat Klein, Orit Sagi-Assif, Tsipi Meshel, Alona Telerman, Sivan Izraely, Shlomit Ben-Menachem, Jagadeesh Bayry, Diego M Marzese, Shuichi Ohe, Dave S B Hoon, Neta Erez, Isaac P Witz

Articles, Abstracts, and Reports

We previously identified the chemokine receptor CCR4 as part of the molecular signature of melanoma brain metastasis. The aim of this study was to determine the functional significance of CCR4 in melanoma brain metastasis. We show that CCR4 is more highly expressed by brain metastasizing melanoma cells than by local cutaneous cells from the same melanoma. Moreover, we found that the expression of CCR4 is significantly higher in paired clinical specimens of melanoma metastases than in samples of primary tumors from the same patients. Notably, the expression of the CCR4 ligands, Ccl22 and Ccl17 is upregulated at the earliest stages …

Pediatric Leukemia: Diagnosis To Treatment–A Review, Samantha C. Bernard, Ehab H. Abdelsamad, Paisley A. Johnson, Daniel L. Chapman, Madhukiran Parvathaneni

Faculty Works

Leukemia is cancer of the blood and bone marrow, it is the most common cancer found in children and is found to be more than one fourth of pediatric cancers. It causes white blood cells to become abnormal and the body to become weak. This deficiency in the immune system reduces the body's ability to fight infection or simple airborne illnesses, causing extensive treatment of common pathogens and cancer treatment. The present review covers all topics, from diagnosis to treatment of pediatric leukemia, as well as the stages of growth and physiological changes throughout the process. As leukemia has a …

Method For Alleviating Side Effects Of Retinoic Acid Therapy And/Or Improving Efficacy Without Interfering With Efficacy, Elaine L. Jacobson, Myron K. Jacobson, Russell Coyle, Hyuntae Kim, Donna L. Coyle

Pharmacology and Nutritional Sciences Faculty Patents

The invention relates to the use of nicotinic acid alkyl esters, especially myristyl nicotinate, to inhibit side effects associated with retinoic acid therapy. Also a part of the invention is a method for improving skin cell differentiation by administering the nicotinic acid alkyl ester in an amount sufficient to increase expression of caspase 14 and filaggrin. Deficiencies in expression of these molecules can be treated in this way as well.

Evidence-Based Treatment Options In Recurrent And/Or Metastatic Squamous Cell Carcinoma Of The Head And Neck., Athanassios Argiris, Kevin J. Harrington, Makoto Tahara, Jeltje Schulten, Pauline Chomette, Ana Ferreira Castro, Lisa Licitra

Department of Medical Oncology Faculty Papers

The major development of the past decade in the first-line treatment of recurrent and/or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN) was the introduction of cetuximab in combination with platinum plus 5-fluorouracil chemotherapy (CT), followed by maintenance cetuximab (the "EXTREME" regimen). This regimen is supported by a phase 3 randomized trial and subsequent observational studies, and it confers well-documented survival benefits, with median survival ranging between approximately 10 and 14 months, overall response rates between 36 and 44%, and disease control rates of over 80%. Furthermore, as indicated by patient-reported outcome measures, the addition of cetuximab …

Organ Donation: A Comparison Of Altruistic And Market-Based Systems, Cameron Caputi

The Downtown Review: An Interdisciplinary Journal Written and Peer-Reviewed by Mandel Honors College Students at Cleveland State University

One of the most heavily regulated aspects of the Health Care industry is the organ donation system (“Legislation and Policy”). Regulations in this area ensure the quality of the organs and morality of the process through which they were procured. This system, however, is failing in at least one sense; the number of patients requiring organ transplants is increasing, but the number of donors remains stagnant (Gordon, Patel, Sohn, Hippen, Sherman , 2014). Due to the lack of available transplant organs, a debate has been sparked on whether the United States government should allow for the purchasing of these organs.

Unreplicable: The Unscientific Nature Of Science Journals, Ernest M. Oleksy

The Downtown Review: An Interdisciplinary Journal Written and Peer-Reviewed by Mandel Honors College Students at Cleveland State University

Academia shapes the way our species looks at veracity and defines what is deemed as well-founded science. The platform for researchers to make their work known is academic journals. The prerogative of these journals is to disseminate technically sound work so that the public may be informed of up-to-date advances in scientific fields. However, these journals are products on the market whose ultimate purpose is to garner a following that will make the producers money. This results in research that does not have statistically significant findings, or replications of past experiments which are integral to supporting the findings of the …

Civility Matters: Overcoming Workplace Incivility Using An Interactive Education Intervention, Joy L. Stoddard

Doctor of Nursing Practice Scholarly Projects

Workplace Incivility, a global issue, particularly affects healthcare settings due to stressful work environments and a largely female workforce. Victims of WPI have up to 33% increased turnover, with many leaving their professions entirely. The cost of turnover, particularly within the first year, may be as high as 125% of the nurse's salary Researchers identified the need to implement measures to prevent and manage WPI. The Joint Commission (TJC) calls for requiring hospitals to implement code-of-conduct policies defining acceptable and unacceptable behaviors. Code-of-conduct policies assist leaders in addressing offenders of WPI. Targets of WPI typically lack the skill set and …

We Are Alfred: Empathy Learned Through A Medical Education Virtual Reality Project, Barbara Swartzlander, Elizabeth Dyer, Marilyn R. Gugliucci

Library Services Faculty Posters

Poster describing project collaboration among University of New England (UNE) librarians and College of Osteopathic Medicine (COM) faculty, whose goal was to adopt technology which will teach UNECOM students to be empathic with older adults and familiarize medical students with information resources from the NIH/NLM related to older adult health. Technology tested was the Alfred Lab developed by Embodied Labs. First year medical students were required to complete the ‘We Are Alfred’ virtual reality module and a pre and post assessment. Descriptive statistics were applied to finite questions on pre and post assessments, and content analysis on open ended answers. …

Representation Of Multiple Body Parts In The Missing-Hand Territory Of Congenital One-Handers., Avital Hahamy, Scott N Macdonald, Fiona Van Den Heiligenberg, Paullina Kieliba, Uzay Emir, Rafael Malach, Heidi Johansen-Berg, Peter Brugger, Jody C Culham, Tamar R Makin

Brain and Mind Institute Researchers' Publications

Individuals born without one hand (congenital one-handers) provide a unique model for understanding the relationship between focal reorganization in the sensorimotor cortex and everyday behavior. We previously reported that the missing hand's territory of one-handers becomes utilized by its cortical neighbor (residual arm representation), depending on residual arm usage in daily life to substitute for the missing hand's function [1, 2]. However, the repertoire of compensatory behaviors may involve utilization of other body parts that do not cortically neighbor the hand territory. Accordingly, the pattern of brain reorganization may be more extensive [3]. Here we studied unconstrained compensatory strategies under …

Assessment Of Nurse Engagement, Manuelita I. Chapman

Doctor of Nursing Practice Scholarly Projects

Organizations with high employee engagement reap the benefits of higher employee retention and improved customer satisfaction. Studies find that engaged workers are in the minority. Among healthcare workers, nurses are found to be the least engaged. The association of the registered nurse (RN) at the bedside with improved patient outcomes has been documented by many. Today, the goal of providing safe, high quality and efficient patient care and an exceptional patient experience are benchmark measures for patient care delivery. Since nurses are essential to optimal patient outcomes, it is important to understand what motivates them. Career advancement programs (CAPs) are …

What's Happening: May 8, 2017, Maine Medical Center

What's Happening

No abstract provided.

Week Of May 8, 2017, New York Medical College

InTouch

• Doctor of Physical Therapy Class of 2019 Celebrates and Reflects at White Coat Ceremony
• Lectureship Honors the Late Gabor Kaley, Ph.D.
• TCDM Hosts Pre-Dental Day
• Touro College of Dental Medicine Hosts ASDA/SPEA Event
• NYMC Collaborates for a Two-Week Global Bioethics Summer Program

Cost Benefit Analysis Of Idaho’S Fit And Fall Proof Program, Susie Bergeron, Michelle Arnett, Sarah Toevs, Tami Cirerol, Rihana Hartung, Linda Petersen, Trina Stolp, Zijada Sulejmanovic, Maria Tellez, Hailee Tilton, Nicole Tuffield, Kenzie Wilson

Public and Population Health Faculty Publications and Presentations

Falls are common among the elderly population. Almost 30% of Idahoans aged 65+ fall at least one time per year (Bergen, Stevens, & Burns, 2016). Falls are a significant source of morbidity, mortality, and healthcare expense. Fall-related injuries often result in expensive hospitalizations with progression into costly long-term care facilities (CDC, 2015). In Idaho, estimated fall-related medical costs are estimated at $253 million annually (CDC, 2016; Mirel & Carper, 2014).

Fit and Fall Proof^TM (FFP), is a fall prevention program serving approximately 2500 community dwelling seniors throughout the state of Idaho. It is an exercise program led by peer …