Medicine and Health Sciences Commons^™

Unfolding Suicidality, Samantha N. Danko

Honors Projects

No abstract provided.

Safety And Immunogenicity Of An Inactivated Whole Cell Tuberculosis Vaccine Booster In Adults Primed With Bcg: A Randomized, Controlled Trial Of Dar-901, C. Fordham Von Reyn, Timothy Lahey, Robert D. Arbeit, Bernard Landry, Leway Kailani, Lisa Adams, Brenda Haynes, Todd Mackenzie, Wendy Wieland-Alter, Ruth Connor, Sue Tvaroha, David Hokey, Ann Ginsberg, Richard Waddell

Dartmouth Scholarship

Development of a tuberculosis vaccine to boost BCG is a major international health priority. SRL172, an inactivated whole cell booster derived from a non-tuberculous mycobacterium, is the only new vaccine against tuberculosis to have demonstrated efficacy in a Phase 3 trial. In the present study we sought to determine if a three-dose series of DAR-901 manufactured from the SRL172 master cell bank by a new, scalable method was safe and immunogenic.

Health & Kinesiology News, Georgia Southern University

Health Sciences & Kinesiology: News & Publications (2015-2023)

• Food Waste, Promotion and Marketing Student Project

Listening Induced Changes In Heart Rate Variability For A Speech-In-Noise Task, Hannah Chapin

AuD Capstone Projects - Communication Sciences and Disorders

There is recent interest in finding psychophysiological measures that are sensitive to listening effort for the young adult population. Listening effort (LE) is defined as the cognitive resources required to attend to and understand speech (Hicks & Tharpe 2002; McGarrigle, et al. 2014; Gosselin & Gagne 2010). This study attempted to further refine HRV as a measure of listening effort to answer questions regarding HRV sensitivity to signal-to-noise ratios (SNR) for listening tasks, uses of temporal and spectral analyses of HRV and their sensitivity to listening induced stress, the effect of the noise type on HRV across SNRs, and effects …

Drumming Past And Present: Examination Of Historical And Current Medicinal Effects, Megan M. Boerema

Honors Projects

Drumming is an activity with a long and rich history, rooted in many different cultures around the world. Traditionally, the art of drumming has been used for a wide variety of purposes including as a part of religious ceremonies, to promote psychological well-being, and to foster a sense of community. It has been used in a variety of cultural healing practices throughout the world since the beginning of ancient history (Newman et al., 2015).

Many cultures use drumming in healing ceremonies as a means for promoting an altered state of consciousness of the ill individual, the healer, and any others …

Cd82 Membrane Scaffolding Regulates Hematopoietic Cell Functions, Christina Marie Termini

Biomedical Sciences ETDs

Through their ability to self-renew and differentiate, hematopoietic stem/progenitor cells (HSPCs) maintain the adult blood and immune systems. The microenvironment, or niche, in which HSPCs reside, serves as a critical regulator of HSPC functions. As previous work has identified the tetraspanin CD82 as a mediator of HSPC-niche interactions, we aimed to determine the mechanism by which this occurs. Our data demonstrate that CD82 expression and scaffolding regulate HSPC interactions with niche components by organizing the α4 integrin subunit into tightly packed nanoclusters. The HSPC niche can also protect acute myeloid leukemia (AML) cells from therapeutics. Therefore, we next examined how …

The Effect Of Bundled Interventions On Prevention Of Hospital Acquired Clostridium Difficile Infection, Kaitlin Kendys

Evidence-Based Practice Project Reports

Clostridium difficile infection (CDI) rates have steadily increased in hospitalized patients due to the change in epidemiology. Approximately 13 of every 1,000 inpatients are either infected or colonized with C. difficile (CDC, 2013). CDI rates continue to rise due to the hyper-virulent strain of C. difficile and length of therapy needed to treat CDI. The average cost for a single inpatient CDI is more than $35,000, and the estimated annual cost burden for the healthcare system exceeds $3 billion (Walsh, 2012). The purpose of this evidence-based project (EBP) was to reduce hospital-acquired CDI rates over a 3-month period-oftime from November …

Characterizing Obesity Risk In Children Receiving Healthcare In An Emergency Department, Lauren Frazzetta

Honors Scholar Theses

Background: Level of adiposity needs to be characterized in children for prevention and treatment of overweight/obesity. This thesis aimed to characterize obesity risk in children, comparing across indirect measures of adiposity, and between perceived body size versus measured adiposity in children and their parents.

Methods: Enrolled was a convenience sample of 925 children receiving health care at a large, urban pediatric emergency department. Child-parent dyads were created and anthropometric and demographic data collected. Age and sex-specific percentiles were determined for body mass index (BMI; measured height/weight) and waist circumference (WC). BMI Z-score was calculated based on age and …

One-Pot Syntheses And Characterizations Of “Click-Able” Polyester Polymers For Potential Biomedical Applications, James F. Beach Ii

Electronic Theses & Dissertations

In this study, a synthetic polyester polymer was designed using polyethylene glycol, sorbitol, glutaric acid and 4-pentynoic acid as monomers. The synthesis was carried out using standard melt polymerization technique and catalyzed by Novozyme-435, an enzyme suitable for polyesterification of biocompatible compounds. The progress of the reaction was monitored with respect to time and vacuum exposure, with samples being subjected to standard characterization protocols. Polymers with high molecular weight and water solubility were chosen for further modification into folate-functionalized polymeric nanoparticles for targeted drug delivery to cancer cells. This was achieved by employing a solvent diffusion method, wherein the polymer …

Zika 2016: A 3-Phase Longitudinal Study Of The Media Impact On Public Attitudes And Behavioral Response Characteristics, Karly Kownslar

Electronic Theses & Dissertations

Using the Extended Parallel Processing Model (EPPM) as a theoretical framework, the present 3-phase longitudinal study examines the impact of media exposure to Zika information on public perception of the threat severity, personal susceptibility, and behavioral intentions toward the threat of Zika virus between May and November of 2016. A total of 826 participants took an online survey throughout three phases, roughly one month apart. Participants were recruited using Amazon Mechanical Turk and TurkPrime. Measured EPPM concepts include: perceived severity, susceptibility, self- efficacy, response-efficacy, third-person effects, combined with behavioral intentions. Participants also selected the sources from which they …

Improved Postpartum Care After A Participatory Facilitation Intervention In Dar Es Salaam, Tanzania: A Mixed Method Evaluation, Eunice Pallangyo, Columba Mbekenga, Pia Olsson, Christine Rubertsson, Carina Källestål

School of Nursing & Midwifery, East Africa

Background: In order to improve the health and survival of mothers/newborns, the quality and attendance rates of postpartum care (PPC) must be increased, particularly in low-resource settings.

Objective: To describe outcomes of a collegial facilitation intervention to improve PPC in government-owned health institutions in a low-resource suburb in Dar es Salaam, Tanzania.

Methods: A before-and-after evaluation of an intervention and comparison group was conducted using mixed methods (focus group discussions, questionnaires, observations, interviews, and field-notes) at health institutions. Maternal and child health aiders, enrolled nurse midwives, registered nurse midwives, and medical and clinical officers participated. A collegial facilitation intervention was …

Research Brief: "The National Veteran Sleep Disorder Study: Descriptive Epidemiology And Secular Trends, 2000–2010", Institute For Veterans And Military Families At Syracuse University

Institute for Veterans and Military Families

This brief is about the relation between sleep disorder diagnosis and cardiovascular disease, cancer, and mental health disorders among veterans. In policy and practice, physicians should familiarize themselves with signs of and screenings for sleep disorders and should discuss factors that affect sleep with their veteran patients; the VHA should continue recommending policies that help veterans receive a prompt diagnosis and treatment of their sleep disorders, policymakers should fund early intervention programs to help veterans learn how to cope with reintegration, and the VHA should create a database on sleep disorders in veterans. Suggestions for future research include studying veterans …

Sleep Deprivation In Hospitalized Patients, Taylor Gibson

Honors Projects

No abstract provided.

The Healing Power Of A Whole Foods, Plant-Based Diet: A Nutrition Prescription For Cancer, Meghan Adelman Mrs.

Master's Projects and Capstones

Chronic disease is quickly overtaking infectious diseases as one of the biggest threats to population health worldwide (Egger, 2012). Studies have shown that plant based diets are effective at reducing prevalence but are also a viable complimentary treatment approach to healing. Further investigation is needed into how plant based diets can reduce risk of recurrence, specifically as it relates to a cancer diagnosis. The Ceres Project is an organization that provides a healing foods philosophy to the care of cancer patients through meal delivery programs at low to no cost. The aim of this research study was to implement the …

Solitary Confinement: Social Death And Its Afterlives, Jen Rushforth

Themis: Research Journal of Justice Studies and Forensic Science

No abstract provided.

Improving Health Outcomes And Lifestyle Choices In An Underserved Community Through The Implementation Of A Wellness Program, Ekaterini Boutos

Seton Hall University DNP Final Projects

Purpose: The purpose of this project was to implement a wellness program with the purpose of bridging the gap in lifestyle and disease knowledge in a socioeconomically vulnerable mentally ill population. The participants were members of an adult day mental health facility which aided the local underserved population. The wellness program emphasized improving knowledge of chronic health conditions, healthy lifestyle habits and the practice of mindfulness meditation.

Significance: The significance of this project is the advancement of health status via health education from a wellness perspective. Vulnerable populations who are at higher risk of chronic physical and mental illness can …

After Closure: Options For Pursuing A High Performance Rural Health System, Andrew F. Coburn Phd

Rural Hospitals (Flex Program)

Presented at the 2017 National Rural Health Association Annual Meeting. Coburn, a member of the Rural Policy Research Institute Panel, discussed the following key questions: What kind of rural health system is possible in places that cannot support a full-service hospital? How does a rural community navigate the transition from hospital-centric care toward new models that deliver high performance? What implementation support will be needed? Coburn noted that there is no single model for re-configuring the rural health system after hospital closure; local assets, affiliations and partnerships, financial and delivery flexibility and capacities must be critically assessed to determine the …

Response Time Scores On A Reflexive Attention Task Predict A Child's Inattention Score From A Parent Report, Erica Suh, Katherine Christensen, Sarah Kamhout, Kahala Thompson, Yoojin Kim, Cooper Hodges

FHSS Mentored Research Conference

● Children with attention deficits have problems with sustained and reflexive attention tasks

● Few studies measure reflexive attention as a component of day-to-day attention in children

● Parents also have valuable insight into children’s behavior

● We want to identify associations between computer-based reflexive attention task performance and parent-rated attention-related problems.

The Effects Of Extracurricular Activity And Physical Activity On Academic Success: A Literature Review, Braden Tanner

FHSS Mentored Research Conference

Due to an ever-increasing importance of education, it is important to understand how to foster an environment conducive to academic success. Extracurricular activity is one of many factors that influences the academic environment. This review examines literature published since 2010 concerning extracurricular activity's effect on academic success. Seeing that sports make up such a large portion of the extracurricular spectrum, the review also examines studies analyzing the effects of physical activity on academic performance.

Listening Effort Outcome Measures In Adult Populations, Melissa Tednes, Scott E. Seeman Phd

AuD Capstone Projects - Communication Sciences and Disorders

Listening effort is being considered clinically as an important indicator of patient success with amplification. Listening effort refers to “the mental exertion required to attend to, and understand, an auditory message”. (McGarrigle et al., 2014) Cognitive ability, age, and degree of hearing impairment all must considered when measuring the effort one is exerting on a specific task. Listening effort can be measured using subjective tools, electrophysiologic measures, or with a dual-task paradigm. Subjective tools include self-reports and questionnaires. Electrophysiologic measures can consist of measuring pupil dilation, heart rate variability, and skin conductance. A dual-task paradigm is set-up with two tasks …

Application Of The Dual-Route Model In Exploring Dyslexia And Dysgraphia In Arabic Speaking Adults With Aphasia: Clinical And Theoretical Implications, Maha Aldera

Seton Hall University Dissertations and Theses (ETDs)

Objective: The cognitive neuropsychology is based on the “universality” assumption, which suggest that all normal people have the same cognitive systems regardless of their culture and language (Coltheart, 2001). The aim of the study is to test the universality assumption of the dual-route model (DRM) for spelling and reading in modern Arabic language. The study follow the same architecture of the DRM taking into considerations specific variables that hold certain features of the Arabic script. Methods: The study results were secured by using case series method analysis of each individual participant’s performance. The Case series method offered the ability to …

Impact Of Ibrutinib Dose Adherence On Therapeutic Efficacy In Patients With Previously Treated Cll/Sll., Paul M Barr, Jennifer R Brown, Peter Hillmen, Susan O'Brien, Jacqueline C Barrientos, Nishitha M Reddy, Steven Coutre, Stephen P Mulligan, Ulrich Jaeger, Richard R Furman, Florence Cymbalista, Marco Montillo, Claire Dearden, Tadeusz Robak, Carol Moreno, John M Pagel, Jan A Burger, Samuel Suzuki, Juthamas Sukbuntherng, George Cole, Danelle F James, John C Byrd

Articles, Abstracts, and Reports

Ibrutinib, an oral inhibitor of Bruton's tyrosine kinase (BTK), at a once-daily dose of 420 mg achieved BTK active-site occupancy in patients with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) that was maintained at 24 hours. It is unknown if intermittent interruption of ibrutinib therapy contributes to altered clinical outcomes. We therefore evaluated the effect of ibrutinib dose adherence on patient outcomes in the phase 3 RESONATE trial. The overall mean dose intensity (DI) was 95% with median treatment duration of ∼9 months. Pharmacokinetic assessment of ibrutinib exposure at 420-mg dose suggested similar exposure regardless of patient weight or age. …

Git R Done: Analysis Of Motivation In Relation To Exercise And Determining Factors, Britton L. Rice

FHSS Mentored Research Conference

Exercise provides many physical, emotional and mental health benefits (Facts about Physical Activity, 2014). Despite this, only 21% of American adults exercise regularly. One way of increasing this is to encourage better understanding of motivation and how to control it. Since intrinsic motivation towards exercise is not easily created or changed, most of the focus is placed on extrinsic motivation in its varying degrees. This summary isolates a few factors in exercise that play crucial roles in deciding motivation such as:

• Climate and Goal Orientation

• Influence of peers and teammates

• Influence of coaches

Implementation Of The Reengineered Discharge Process And Transitional Care Management At A Rural Critical Access Hospital, Chad L. Wilfong

Doctoral Projects

Healthcare in the United States is changing from a fee-for-service to a value based healthcare delivery system. One area of national focus is reducing 30-day hospital readmissions by providing high-quality transitions-of-care. Patients leaving the hospital without proper assessment of home care needs, patient education, and coordination of care run into barriers managing health conditions, which contributes to hospital readmissions. Poor transitions-of-care contribute to deterioration of health leading to acute care utilization and hospital readmissions, which is costly for healthcare organizations, insurance payers, and individuals. In 2017, the value based healthcare structure will be decreasing reimbursement to hospitals that have 30-day …

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Georgia Southern Student Graduates at 19

Expectations And Memory: Positive And Negative Expectations Of Memorizing The Armenian Alphabet, Micah Wood, Madeline Hoyt

FHSS Mentored Research Conference

Studies suggest that expectations may have an effect on various cognitive functions, including memory. To this point, no studies have exclusively investigated the effect of expectations on short-term memory. This study tested the effect of positive and negative expectations on short-term memory, utilizing the Armenian alphabet as a test of memory. N=45 undergraduate students (23 men, 22 women), ranging in age from 18-26 years were divided equally into three groups: Group 1 was a control group, Group 2 was manipulated to have positive expectations before testing, and Group 3 was manipulated to have negative expectations before testing. All groups were …

Hazcom 2012 Implementation, Cheri Marcham

Publications

This presentation reviews changes to the OSHA Standard called HazCom 2012. Old and new definitions for "health hazards" are discussed as well as labeling requirements.

Infant Siblings Of Children Diagnosed With Autism Spectrum Disorder Have Higher Perseveration, Katherine Christensen, Allison Garner Kotter, Rachel Nuttall, Bread Iverson, Taylor Bayles

FHSS Mentored Research Conference

● Children with ASD have difficulty with social cues, repetitive behaviors, and restricted interests

● Many of these signs show up after a diagnosis and many children remain undiagnosed until school-age

● We want to demonstrate the utility of a screening tool to identify infants at risk for ASD

● This tool could enable earlier identification and treatment for those who have unknown risk for ASD

Exploring The Burnout Experience Of Radiology Physician Executives Working In An Academic Medical Institution: A Mixed Methods Approach, Julie Chapman-Greene

Seton Hall University Dissertations and Theses (ETDs)

Radiology Physician Executives (Radiology PEs) perform administrative duties and they have frequent and prolonged contact with patients, residents, fellows, faculty and staff. This study, using the Maslach Burnout Inventory Human Services Survey to measure burnout in a convenient sample of Radiology PEs working in accredited academic medical institutions, is the first one to evaluate burnout in this group. The purpose of this study was to explore the burnout experience of Radiology PEs by investigating their burnout rate, understanding their burnout experience and explore a theory on how Radiology PEs think about, perceive, experience and manage burnout. The study describes the …

The Relationship Of Anthropometric Ratios And Kinematic & Kinetic Measures Of The Hip In Recreational Male Athletes Performing The Back Squat, Jay C. Garrels

Seton Hall University Dissertations and Theses (ETDs)

The back squat exercise is a popular resistance exercise that involves synchronous movement of the entire body to perform the movement properly . The two main focuses when considering engaging in the back squat exercise are the risks of injury and the enhancement of performance. There is little information and scant understanding on the way body proportionality impacts the risk of injury and performance. The present study investigated this issue by investigating if there was a relationship between anthropometric ratios and kinematic & kinetic outcomes from the left and right hip when experienced, male back squatters performed a single repetition …