Medicine and Health Sciences Commons^™

Mortality In Patients With Respiratory And Nonrespiratory Carbapenem Resistant-Multidrug Resistant Acinetobacter Infections, Nosheen Nasir, S Mahmood

Department of Medicine

Background: Mortality from carbapenem-multi-drug resistant Acinetobacter infections may vary according to site of infection. The objective of this study was to compare mortality in respiratory vs. non-respiratory infection with Carbapenem-Multi-drug Resistant Acinetobacter (C-MRAB).

Methods: We conducted a prospective cohort study to compare mortality rate in patients with respiratory vs. nonrespiratory infection (n=30 each).

Results: Results showed that mortality was 40% in the respiratory group compared to 23% in non-respiratory group; the difference was not statistically significant (p=0.165, RR=1.71, CI=0.73-3.75). There was a significantly higher prior admission rate in patients with respiratory infection (p=0.028). Logistic regression did not reveal any modifier …

July 2017, Swosu Bulldog Wellness Committee

SWOSU BULLDOG WELLNESS

No abstract provided.

Body Mass Index Adjustments To Increase The Validity Of Body Fatness Assessment In Uk Black African And South Asian Children, M. T. Hudda, C. M. Nightingale, A. S. Donin, M. S. Fewtrell, D. Haroun, S. Lum, J. E. Williams, C. G. Owen, A. R. Rudnicka, J. C.K. Wells, D. G. Cook, P. H. Whincup

All Works

© 2017 Macmillan Publishers Limited, part of Springer Nature. BACKGROUND/OBJECTIVES: Body mass index (BMI) (weight per height2) is the most widely used marker of childhood obesity and total body fatness (BF). However, its validity is limited, especially in children of South Asian and Black African origins. We aimed to quantify BMI adjustments needed for UK children of Black African and South Asian origins so that adjusted BMI related to BF in the same way as for White European children. METHODS: We used data from four recent UK studies that made deuterium dilution BF measurements in UK children of White European, …

Incidence And Pattern Of Thrombocytopenia In Cardiac Surgery Patients, Mohammad Hamid, Mohammad Irfan Akhtar, Hamid Iqil Naqvi, Khalid Ahsan

Department of Anaesthesia

Objective: To observe the incidence and pattern of thrombocytopenia in cardiac surgery patients.
Methods: This prospective, cohort study was conducted at the Aga Khan University Hospital, Karachi, from November 2014 to April 2015, and comprised adult cardiac patients. Patients with platelet count less than 150,000 x 109/L, history of malignancy, immune thrombocytopenic purpura and on chemo or radiotherapy were excluded. All information including demographics, platelet count, heparin doses, total cardiopulmonary bypass time, cross-clamp time, blood products transfused, any thromboembolic complication and the presence of infection were recorded on a pre-designed proforma. SPSS 19 was used for data analysis..
Results: Of …

Development Of An Early Expository Text Comprehension Assessment: A Pilot Study, Stacey Christianson

Theses and Dissertations

Literature supporting the use of informational texts with preschool children has increased in recent years. However, many preschool classrooms still focus on narrative text, and teachers are often unsure how to provide support for children's comprehension of informational texts. An assessment addressing preschool children's informational text comprehension will help teachers understand what children can do with informational texts and point out demands or tasks that children should be able to handle. A comprehension assessment for preschool children focusing on text purpose, text features, text retell, and comprehension of text structures has not been available. To fit this need, recent effort …

The Relationship Between Auditory Habituation And Anxiety In Autism Spectrum Disorder, David Nicholas Top

Theses and Dissertations

Many individuals with autism spectrum disorder (ASD) have atypical sensory processing and behaviors including sensory sensitivity and low registration of sensory stimuli as well as sensory seeking and avoiding behaviors. Additionally, many individuals with ASD have clinically distressing levels of anxiety. Previous research suggests that there is a link between abnormal sensory processing, anxiety, and ASD. The purpose of this study was to experimentally observe auditory sensory processing using pupillometry methods, between ASD, control, and high-anxious control groups. While a difference in tonic pupil size was observed, there were no reactivity or habituation differences between the groups. There were no …

The Ability Of Five Children With Language Impairment To Describe Mental State In Story Narratives In Spontaneous And Prompted Conditions: Does It Help To Ask?, Naomi Asai

Theses and Dissertations

Numerous studies have shown that children identified with Language Impairment (LI) have marked difficulty with producing story narratives compared to their typically developing peers. One particular area of weakness seen in the narratives of children with LI is their ability to incorporate internal states, specifically internal response, internal plan, and emotion words. The current study examines five children with LI and their descriptions of mental and emotional states of characters in story narratives under spontaneous and prompted conditions. Participants produced story retells based on a series of wordless picture books taken from the Edmonton Narrative Norms Instrument. Story retells were …

Resolution Of Occlusive Carotid Artery Thrombus Treated With Anticoagulation As Demonstrated On Duplex Ultrasonography., Laura Stein, John W. Liang, Jesse Weinberger

Department of Neurology Faculty Papers

BACKGROUND AND PURPOSE: While the majority of cerebral ischemic events due to carotid occlusive disease result from atherosclerotic plaque rupture, intraluminal carotid artery thrombus occasionally occurs in patients without preexisting carotid atherosclerosis. Identification of nonatherosclerotic thrombus as the cause of the carotid occlusive disease can obviate the need for an interventional procedure, and resolution of thrombus can be monitored with B-mode duplex ultrasonography.

METHODS: We reviewed 3 patients treated on The Mount Sinai Hospital Stroke Unit with anticoagulation for nonatherosclerotic carotid thrombi and followed with serial Doppler ultrasonogrpahy for resolution of thrombus.

RESULTS: Occlusive carotid thrombus was successfully treated in …

What Roles Do Chinese Health Sciences Libraries Play In Their Nation's Cigarette Smoking Public Health Crisis?, Charles J. Greenberg, Lin Wu, Xuyu Zhou, Susan Yutong Feng, Sam Bodong Chen

Library Philosophy and Practice (e-journal)

Objectives: Cigarette smoking remains a major cause of death in China. Are health sciences libraries in China currently providing awareness, advocacy, or research support for the societal benefits of smoking reduction? Methods: Following institutional review board approval, Library contacts for Chinese schools of medicine, public health, and pharmacy were identified. A bilingual online survey was constructed to obtain respondents’ demographic detail and answers to questions about library resources and services that constitute academic awareness, advocacy, curriculum, or research support about tobacco and smoking. Results: 43% of reporting librarians work on a smoke-free campus. 100% of all reporting libraries work in …

Cesarean In The Second Stage: A Possible Risk Factor For Subsequent Spontaneous Preterm Birth., Vincenzo Berghella, Alexis C. Gimovsky, Lisa D. Levine, Joy Vink

Department of Obstetrics and Gynecology Faculty Papers

No abstract provided.

Lung Rest During Extracorporeal Membrane Oxygenation For Neonatal Respiratory Failure-Practice Variations And Outcomes., Deepthi Alapati, Zubair H. Aghai, Jobayer Hossain, Daniel R Dirnberger, Mark T. Ogino, Thomas H. Shaffer

Department of Pediatrics Faculty Papers

OBJECTIVE: Describe practice variations in ventilator strategies used for lung rest during extracorporeal membrane oxygenation for respiratory failure in neonates, and assess the potential impact of various lung rest strategies on the duration of extracorporeal membrane oxygenation and the duration of mechanical ventilation after decannulation.

DATA SOURCES: Retrospective cohort analysis from the Extracorporeal Life Support Organization registry database during the years 2008-2013.

STUDY SELECTION: All extracorporeal membrane oxygenation runs for infants less than or equal to 30 days of life for pulmonary reasons were included.

DATA EXTRACTION: Ventilator type and ventilator settings used for lung rest at 24 hours after …

Markerless Kinematics Of Pediatric Manual Wheelchair Mobility, Jacob Robert Rammer

Dissertations (1934 -)

Pediatric manual wheelchair users face substantial risk of orthopaedic injury to the upper extremities, particularly the shoulders, during transition to wheelchair use and during growth and development. Propulsion strategy can influence mobility efficiency, activity participation, and quality of life. The current forefront of wheelchair biomechanics research includes translating findings from adult to pediatric populations, improving the quality and efficiency of care under constrained clinical funding, and understanding injury mechanisms and risk factors. Typically, clinicians evaluate wheelchair mobility using marker-based motion capture and instrumentation systems that are precise and accurate but also time-consuming, inconvenient, and expensive for repeated assessments. There is …

Examining The Durability Of Peers For Adolescents With Asd: Maintenance Of Neurological And Behavioral Effects, Bridget Kathleen Dolan

Dissertations (1934 -)

To date, there are no known published studies that have assessed the maintenance of treatment effects in the context of neurological changes and their relationship to behavioral outcomes following a social skills intervention for adolescents with Autism Spectrum Disorder (ASD). The few studies that have incorporated long-term assessment into their design have focused exclusively on sustained behavioral responses to treatment. Individuals with ASD across the lifespan exhibit aberrant neural activity, which is thought to underlie social skill deficits noted in persons on the spectrum. Thus, this study sought to examine the impact of a social skills intervention, the Program for …

The Neural Encoding Of Reward In The Striatal-Pallidal Circuitry, Chung Lung Chan

Dissertations (1934 -)

Humans and animals are constantly exposed to external stimuli. The ability to process reward value of a stimulus is critical to guiding appropriate behavior and essential for survival. These processes are regulated by neuronal activity and neurochemical signaling in the reward circuitry, particularly in the nucleus accumbens (NAc). The NAc receives dopaminergic inputs from the midbrain ventral tegmental area (VTA) and sends GABAergic projections to the ventral pallidum (VP). Electrophysiological studies have characterized phasic neuronal responses in the NAc that differential encode appetitive and aversive taste stimuli. Exposure to an appetitive taste stimulus evoked predominantly phasic inhibitory responses in the …

The Social And Historical Subject In Sartre And Foucault And Its Implications For Healthcare Ethics, Kimberly Siobhan Engels

Dissertations (1934 -)

This dissertation explores Jean Paul Sartre’s and Michel Foucault’s view that subjectivity is socially and historically constituted. Additionally, it explores their corresponding ethical thought and how these viewpoints can be applied to ethical issues in the delivery of healthcare. Sartre and Foucault both hold the view that human beings as subjects are not just participants or spectators in social practices, rather, they become subjects with ontological possibilities through their interaction with these practices. In Chapter One, I trace Sartre’s views on subjectivity in his two major works Being and Nothingness and The Critique of Dialectical Reason, Volume 1, showing how …

Rediscovery Of The Microtubule System In Chlamydomonas, Yi Liu

Dissertations (1934 -)

Extensive studies have revealed the complex mechanisms underlying the roles of the microtubule system in fundamental cellular processes, the severe consequences in development and health resulted from its anomaly, and the irreplaceable therapeutic agents that perturbs this vital yet inherently unstable cytoskeletal system. Most of the concepts derived from a handful of model organisms become dogma of the field despite contrary observations. By overcoming a major limitation of biflagellate green alga Chlamydomonas - the intense autofluorescence common to photosynthetic cells - this dissertation discovered new phenomena of the microtubule system and conceived an invention. The microtubule system of the green …

Neuromuscular Function In Women Postpartum, Rita Deering

Dissertations (1934 -)

Efficient abdominal muscle function is important for functional mobility in men and women, and dysfunction of these muscles has been associated with impaired function such as low back pain. This dissertation explored abdominal muscle function in healthy young men and young women who have never been pregnant (nulligravid). As pregnancy and child birth also impact the tissues of the abdominal wall, this dissertation will also explore abdominal muscle function in postpartum women. This dissertation involved three primary aims. Aim1 compared abdominal muscle function and experimental pain perception in males and nulligravid females. Maximal strength over a range of trunk angles, …

The Noncanonical Roles Of Two Primordial Molecules In Flagella, Xiaoyan Zhu

Dissertations (1934 -)

Motile cilia and flagella are ancient organelles that eukaryotic organisms today still rely on to thrive in their natural environment. Not surprisingly, accumulated evidence has shown that the intricate motility machinery, the microtubule-based axoneme, is evolutionarily conserved down to the molecular level. This notion is epitomized by the signature axonemal complex, the radial spoke (RS). The RS is part of a control center conferring the high frequency and tightly regulated movement. Key RS proteins discovered in biflagellate green alga, Chlamydomonas reinhardtii, are also generated by nearly all ciliated organisms, including Homo sapiens. Among them are two subunits from primordial protein …

The Development And Psychometric Analysis Of The Mu- Fertility Knowledge Assessment Scale, Qiyan Mu

Dissertations (1934 -)

Young women between the ages of 18 to 24 experience disproportionally high rates of negative sexual and reproductive health outcomes. Inadequate and inaccurate fertility knowledge can hinder a young woman’s self-care abilities in managing her sexual and reproductive health. There is no validated instrument to assess young women’s fertility knowledge. The primary purpose of this study is to develop and evaluate the psychometric properties of the MU-fertility knowledge assessment scale (MU-FKAS) for young women. The secondary purpose is to explore the relationships among young women’s individual and contextual factors, self-perceived fertility knowledge, actual fertility knowledge, and fertility health risks. A …

Phytochemical Analysis And Antioxidant Potential Of Ficus Benghalensis L., Haroon Ahmed, Muhammad Zafar Irshad Khan, Durdana Waseem, Adila Nazli, Muhammad Waleed Baig

Journal of Bioresource Management

Genus Ficus belongs to family Moraceae having 40 genera and over 1000 species worldwide. Different methods have been used for phytochemical screening of medicinal plants like total phenolics content (TPC) and total flavonoids content (TFC) assays to quantify phenolics and flavonoids. The phytochemical analysis exhibited highest total phenolics content in M extract of stem and total flavonoids content in ethyl acetate (EA) extract of leaves i.e. 61.2±1.3 µg GAE/mg extract and 25.1±0.9 µg QE/mg extract respectively. Total reduction power and total antioxidant capacity were maximum in the M extract of stem i.e. 243.89±1.6 µg AAE/mg extract and 127.08±2.7 µg AAE/mg …

Rsv Associated Hospitalizations In Children In Karachi, Pakistan: Implications For Vaccine Prevention Strategies, Syed Asad Ali, Mohammad Tahir Yousafzai, Rabbia Waris, Fatima Jafri, Fatima Aziz, Imran Naeem Abbasi, Anita K. M. Zaidi

Department of Paediatrics and Child Health

Major progress is being made in vaccines against Respiratory Syncytial Virus (RSV), with multiple vaccine candidates currently in the clinical phase of development. Making an investment case for public sector financing of RSV vaccine will require estimation of burden, cost-effectiveness, and impact. The aim of this study is to determine the proportion, age distribution and clinical spectrum of RSV associated hospitalizations in children in Karachi, Pakistan. A three years prospective study was conducted at the Aga Khan University Hospital in Karachi, a city of 20 million in south Pakistan, from August 2009 to June 2012. Children less than five years …

Experience With The Quantitative Lyta Gene Real-Time Polymerase Chain Reaction For The Detection Of Streptococcus Pneumoniae From Pediatric Whole Blood In Pakistan, Furqan Kabir, Sahrish Muneer, Adil Kalam, Ana Sami, Shahida Qureshi, Aneeta Hotwani, Atif Riaz, Syed Mohiuddin, Mohammad Tahir Yousafzai, Sara Hussain, Syed Asad Ali, Sadia Shakoor

Department of Paediatrics and Child Health

Background: We present our experience with optimization and diagnostic use of quantitative real-time polymerase chain reaction (PCR) targeting the lytA gene of Streptococcus pneumoniae for the detection of S. pneumoniae in whole blood of children ≥5 CFU/10 μl or 1 copy of DNA/2 μl of blood.
Methods: This assay was applied on 1912 whole blood specimens collected from children pneumonia, of which 35 specimens were lytA positive. The bacterial loads were determined through categorization of load into five different categories, i.e., very high load, high load, moderate load, low load, and very low load.
Results: Of the 35 lytA-positive …

Insula And Amygdala Resting-State Functional Connectivity Differentiate Bipolar From Unipolar Depression, E Ambrosi, D B Arciniegas, A Madan, K N Curtis, M A Patriquin, R E Jorge, G Spalletta, J C Fowler, B C Frueh, R Salas

Staff and Researcher Publications

Objective: Distinguishing depressive episodes due to bipolar disorder (BD) or major depressive disorder (MDD) solely on clinical grounds is challenging. We aimed at comparing resting-state functional connectivity (rsFC) of regions subserving emotional regulation in similarly depressed BD and MDD.

Method: We enrolled 76 in-patients (BD, n = 36; MDD, n = 40) and 40 healthy controls (HC). A seed-based approach was used to identify regions showing different rsFC with the insula and the amygdala. Insular and amygdalar parcellations were then performed along with diagnostic accuracy of the main findings.

Results: Lower rsFC between the left insula and the left mid-dorsolateral …

Parent-Reported Problematic Sleep Behaviors In Children With Comorbid Autism Spectrum Disorder And Attention-Deficit/Hyperactivity Disorder, Katharine C Reynolds, Michelle Patriquin, Candice A Alfano, Katherine A Loveland, Deborah A Pearson

Staff and Researcher Publications

Background: Sleep problems are frequent and well documented in children with Autism Spectrum Disorders (ASD), children with Attention Deficit/Hyperactivity Disorder (ADHD) and children with internalizing problems, however limited work has examined sleep problems in children presenting with comorbid ASD/ADHD. In healthy children, sleep problems negatively impact social, emotional, and academic functioning. The current study sought to examine diagnostic severity as predictors of sleep problems in children with comorbid ASD/ADHD. Additionally, the association between sleep and "real-life" functional domains (i.e., intellectual functioning, academic achievement, and executive functioning) were assessed.

Method: Sleep, internalizing difficulties, intellectual functioning, academic achievement and executive functioning were …

Effect Of Evacetrapib On Cardiovascular Outcomes In Patients With High-Risk Cardiovascular Disease, Wilbert S. Aronow

NYMC Faculty Publications

No abstract provided.

Prevalence, Treatment, And Control Rates Of Conventional And Ambulatory Hypertension Across 10 Populations In 3 Continents, Jesus D. Melgarejo, Gladys E. Maestre, Lutgarde Thijs, Kei Asayama, José Boggia, Edoardo Casiglia, Tine W. Hansen

School of Medicine Publications

Hypertension is a major global health problem, but prevalence rates vary widely among regions. To determine prevalence, treatment, and control rates of hypertension, we measured conventional blood pressure (BP) and 24-hour ambulatory BP in 6546 subjects, aged 40 to 79 years, recruited from 10 community-dwelling cohorts on 3 continents. We determined how between-cohort differences in risk factors and socioeconomic factors influence hypertension rates. The overall prevalence was 49.3% (range between cohorts, 40.0%-86.8%) for conventional hypertension (conventional BP ≥140/90 mm Hg) and 48.7% (35.2%-66.5%) for ambulatory hypertension (ambulatory BP ≥130/80 mm Hg). Treatment and control rates for conventional hypertension were 48.0% …

Prevalence, Treatment, And Control Rates Of Conventional And Ambulatory Hypertension Across 10 Populations In 3 Continents, Jesus D. Melgarejo, Gladys E. Maestre, Lutgarde Thijs, Kei Asayama, José Boggia, Edoardo Casiglia, Tine W. Hansen

School of Medicine Publications

Hypertension is a major global health problem, but prevalence rates vary widely among regions. To determine prevalence, treatment, and control rates of hypertension, we measured conventional blood pressure (BP) and 24-hour ambulatory BP in 6546 subjects, aged 40 to 79 years, recruited from 10 community-dwelling cohorts on 3 continents. We determined how between-cohort differences in risk factors and socioeconomic factors influence hypertension rates. The overall prevalence was 49.3% (range between cohorts, 40.0%-86.8%) for conventional hypertension (conventional BP ≥140/90 mm Hg) and 48.7% (35.2%-66.5%) for ambulatory hypertension (ambulatory BP ≥130/80 mm Hg). Treatment and control rates for conventional hypertension were 48.0% …

Risk And Protective Factors In The Lives Of Caregivers Of Persons With Autism: Caregivers’ Perspectives, Abir K. Bekhet, Denise M. Matel-Anderson

College of Nursing Faculty Research and Publications

PURPOSE

The purpose of this descriptive exploratory study is to understand the experience of being a caregiver of a person with autism spectrum disorder (ASD) in the light of the resilience theory.

METHODS

Qualitative data were collected as a part of a larger quantitative study. Ninety-three caregivers completed this qualitative study and responded to the two open-ended questions. In the parent study, subjects were recruited by convenience sampling from the Interactive ASD Network (IAN).

FINDINGS

The identified categories appeared to reflect three distinct categories consistent with the resilience theory, labeled as follows: risk factors, protective factors, and overlapping factors.

PRACTICE …

Predictive Value Of Adhd Symptomatology On Motives And Outcomes Of Stimulant Misuse, Alexander Laszlo Peterkin

Psychology Theses & Dissertations

ADHD stimulant misuse is defined as taking a stimulant used to treat ADHD either without having a prescription for that stimulant or in a manner that deviates from the prescription’s instructions. This has been a growing trend among undergraduate students over recent years. Prior research has found that misusers are likely to have severe symptoms of ADHD, misuse for primarily academic reasons, and display problems associated with substance abuse. The current study aimed to determine the predictive value of ADHD symptomatology on frequency of ADHD stimulant misuse, mediated by academic motives for misuse and substance abuse problems. The survey for …

Breaking The Silence: A Phenomenological Exploration Of Secondary Traumatic Stress In U.S. College Student Affairs Professionals, Robert Jason Lynch

Educational Leadership & Workforce Development Theses & Dissertations

Breaking the Silence: A Phenomenological Exploration of Secondary Traumatic Stress in U.S. College Student Affairs Professionals is a qualitative-intensive mixed methods study using phenomenology and art-based research techniques to uncover the essence of secondary traumatic stress in U.S. college student affairs professionals. Researchers in the fields of psychology, counseling, social work and other helping professions suggest that repeated exposure to individuals experiencing trauma, or hearing repeated details of an individual’s trauma, have negative outcomes on professional helpers. Coined secondary traumatic stress, this phenomenon may be defined as “the stress resulting from helping or wanting to help a traumatized or suffering …