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Articles 391 - 420 of 16623
Full-Text Articles in Medicine and Health Sciences
Patient-Provider Relationship And Perceived Provider Weight Bias Among American Indians And Alaska Natives, Kelly L. Gonzales, Ginny Garcia, Michelle M. Jacob, C. Muller, Lonnie A. Nelson, Spero M. Manson
Patient-Provider Relationship And Perceived Provider Weight Bias Among American Indians And Alaska Natives, Kelly L. Gonzales, Ginny Garcia, Michelle M. Jacob, C. Muller, Lonnie A. Nelson, Spero M. Manson
OHSU-PSU School of Public Health Faculty Publications and Presentations
Objective The objective of this study was to examine patient–provider relationships among American Indians and Alaska Native (AI/AN) patients by examining associations between patient activation, perceived provider weight bias and working alliance. Patient activation is generally defined as having the knowledge, skills and confidence to manage one's health.
Methods Among a sample of 87 AI/AN adults presenting for general medical care at an urban clinic in the north-west region of the USA, ordinary least squares regression analysis was completed to examine associations.
Results Better working alliance scores were associated with increased patient activation, while perceived provider weight bias was associated …
Prostate Cancer Microparticles In Men Undergoing Radical Prostatectomy, Malcolm James Dewar
Prostate Cancer Microparticles In Men Undergoing Radical Prostatectomy, Malcolm James Dewar
Electronic Thesis and Dissertation Repository
Objectives: To determine changes in prostate microparticle (PMP) concentrations in men with prostate cancer (PCa) after digital rectal examination (DRE), after radical prostatectomy (RP), and at follow-up.
Materials and Methods: 22 men were recruited before RP. Four blood specimens were collected – baseline (specimen 1), post-DRE (specimen 2), immediately post-RP (specimen 3), and follow-up (specimen 4). Pre- and post-DRE urine was collected (Specimen A and B respectively). Flow cytometric analysis of biofluids was performed with fluorescent-labeled antibodies against prostate-specific membrane antigen (PSMA) and polysialic acid. Total MP (TMP) and dual positive (PMP) events per µl of plasma or urine were …
Liver X Receptor And Retinoid X Receptor In Cartilage Development And Homeostasis, Man-Ger Sun
Liver X Receptor And Retinoid X Receptor In Cartilage Development And Homeostasis, Man-Ger Sun
Electronic Thesis and Dissertation Repository
Osteoarthritis (OA) is a heterogeneous and multifactorial degenerative disease characterized by cartilage degradation in the joint. Available treatment options target symptoms but do not address the underlying issue of joint tissue degeneration. A better understanding of the molecular mechanisms maintaining cartilage health is essential for developing novel therapeutic strategies. Previous studies have shown the nuclear receptor Liver X Receptor (LXR) to possess protective roles against cartilage breakdown in OA, however the underlying mechanisms behind this process remain unknown. Since LXR regulates transcription by forming obligate heterodimers with another nuclear receptor, the Retinoid X Receptor (RXR), I hypothesized that LXR and …
Effects Of Prenatal Bisphenol A Exposure On Adrenal Gland Development And Steroidogenic Function, Samantha Medwid
Effects Of Prenatal Bisphenol A Exposure On Adrenal Gland Development And Steroidogenic Function, Samantha Medwid
Electronic Thesis and Dissertation Repository
Developmental exposure to bisphenol A (BPA), a ubiquitous endocrine disrupting chemical, is associated with organ dysfunction and diseases in adulthood. However, little is known about its effects on the adrenal glands. Therefore, this thesis addresses this important question using both in vivo and in vitro approaches. BPA at environmentally relevant doses was administrated via diet to pregnant mice from embryonic day 7.5 to birth, following which mice were switched to a standard chow. At two months postnatally, adrenal glands and blood samples were collected from adult mouse offspring for structural and functional analysis. I found that: (a) BPA increased adrenal …
Hepcidin-Mediated Iron Regulation In P19 Cells Is Detectable By Mri, Kobra Alizadeh Pourbouyeh
Hepcidin-Mediated Iron Regulation In P19 Cells Is Detectable By Mri, Kobra Alizadeh Pourbouyeh
Electronic Thesis and Dissertation Repository
Magnetic resonance imaging (MRI) can be used to track cellular activities in the body using iron-based contrast agents. However, intrinsic cellular iron handling mechanisms may also influence the detection of magnetic resonance (MR) contrast. For instance, inflammation involves downregulation of iron export in macrophages by the hormone hepcidin, due to degradation of the iron export protein, ferroportin (Fpn). We examined the effect of hepcidin on iron regulation and MR transverse relaxation rates in multi-potent P19 cells, which display high iron export activity, similar to macrophages. In response to varying conditions of iron supplementation, our results showed similar Fpn expression in …
Proteomic Characterization Of Human Multipotent Stromal Cells Secreted Proteins With Therapeutic Potential For Β-Cell Regeneration, Miljan Kuljanin
Proteomic Characterization Of Human Multipotent Stromal Cells Secreted Proteins With Therapeutic Potential For Β-Cell Regeneration, Miljan Kuljanin
Electronic Thesis and Dissertation Repository
Novel strategies to stimulate the expansion of β-cell mass in situ are warranted for diabetes therapy. Cell-replacement therapies for the treatment of diabetes have become a focal point in recent years. Endogenous regeneration of β-cell mass has been demonstrated using human multipotent stromal cells (hMSC). However, the secretory factors responsible for initiating endogenous regeneration remain unknown. Successful large-scale proteomic applications to address these questions have been limited in part by difficulties in correctly selecting the appropriate methodologies. Thus, the goal of this thesis was a combination of assessing different proteomic workflows to facilitate investigation into hMSC biology, applying these methods …
Crispr Screen For Identification Of Kinases That Mediate Prostate Cancer Cell Invasion, Hamad Aldhafeeri
Crispr Screen For Identification Of Kinases That Mediate Prostate Cancer Cell Invasion, Hamad Aldhafeeri
Electronic Thesis and Dissertation Repository
Metastasis is the primary cause of mortality in cancer patients. Inhibition of proteins that are involved in the regulation of metastasis are expected to suppress metastasis and represent treatment targets. Our focus is on prostate cancer metastasis and we have developed a novel high-throughput means of performing in vitro screens for regulators of prostate cancer metastasis. We propose to use a focused CRISPR library screen that will “knock out” all human kinases to determine which ones are responsible for prostate cancer metastasis. CRISPR is a potent genetic editing tool and was used to silence all kinases in prostate cells (BPH …
Deconstructing The Visa: Academic Accommodations And Self-Disclosure, Catherine A. Smith Phd
Deconstructing The Visa: Academic Accommodations And Self-Disclosure, Catherine A. Smith Phd
Proceedings from the Document Academy
College students living with disabilities must disclose, manage, share, and communicate their personal health information in order to receive academic accommodations. The academic gatekeepers to this process are disability services specialists who are important “third parties:” non-family members, non-friends, who work with clinical information to meet the educational needs of their student clients. The author reports the results of the first of several studies of different stakeholders in the academic accommodations process and their attitudes about Personal health records (PHRs). Semistructured interviews were conducted between January and April, 2013, with 17 Disabilities Services (DS) specialists at 2 different public 4-year …
Evidence Based Protocol: Improving Nutrition Monitoring In Hospitalized Adults, Philip W. Jackson
Evidence Based Protocol: Improving Nutrition Monitoring In Hospitalized Adults, Philip W. Jackson
Master's Projects
Malnutrition affects a large number of adult inpatients. For these patients, the implications of the high rate of malnutrition include impaired wound healing, higher rates of infection, and an increased risk of death. These complications contribute to increased healthcare costs and longer lengths of stay. The level of monitoring and documentation of patients’ meal consumption was acknowledged to be below expectations in an acuity-adaptable neurosciences unit situated in a downtown hospital located in the Midwestern United States. The define-measure-analyze-improve-control (DMAIC) quality improvement framework guided the quality improvement team to develop a standard process for meal related activities. The rate of …
The Effects Of Exercise On Mental Health: A Research Review, Kaylani Benson
The Effects Of Exercise On Mental Health: A Research Review, Kaylani Benson
Honors College Theses
This research review looks at the effects exercise and physical activity have on mental health. The results of this review are based upon the results of the formal studies that have been included. These studies are Benefits of Exercise on Physical and Mental Health in Rheumatoid Arthritis Patients, Exercise Effects on Mental Health of Preschool Children, The Effect of Morning Exercise on Mental Health of Female Police Employees, Exercise and Mental Health of People Living with HIV: A Systemic Review, Exercise Improves Physical Function and Mental Health of Brain Cancer Survivors: Two Exploratory Case Studies, Effect of Yogic and Physical …
Embodied Nonverbal Microaggressions From The Perspective Of Dance/Movement Therapists: Interpretative Phenomenological Analysis, Rebecca A. Schultz
Embodied Nonverbal Microaggressions From The Perspective Of Dance/Movement Therapists: Interpretative Phenomenological Analysis, Rebecca A. Schultz
Creative Arts Therapies Theses
This interpretative phenomenological analysis (IPA) study explored dance/movement therapist’s embodied experiences of nonverbal microaggressions and how they experience nonverbal microaggressions in the clinical relationship. Data were collected via hour-long, video recorded, in-person interviews of four (N = 4) current practicing dance/movement therapists in the Chicago area. Data analysis was conducted using IPA of verbal and movement data where five key themes emerged (a) personal offense, (b) anger, and (c) curiosity towards experiences of nonverbal microaggressions; and microaggressions have the potential to both (d) strengthen and (e) harm the clinical relationship. Their experiences implicate the vital role the body plays in …
Erratum: Correction To: Characteristics Of Therapeutic Alliance In Musculoskeletal Physiotherapy And Occupational Therapy Practice: A Scoping Review Of The Literature (Bmc Health Services Research (2017) 17 1 (375)), Folarin Babatunde, Joy Macdermid, Norma Macintyre
Erratum: Correction To: Characteristics Of Therapeutic Alliance In Musculoskeletal Physiotherapy And Occupational Therapy Practice: A Scoping Review Of The Literature (Bmc Health Services Research (2017) 17 1 (375)), Folarin Babatunde, Joy Macdermid, Norma Macintyre
Bone and Joint Institute
CORRECTION: Following publication of the original article [1], an erratum was initiated in order to include supplementary material that was not updated and not included during the online submission of the authors' corrections. The additional corrections, included below, are to Appendix II. The original article has been corrected.
Community Development Projects In Moldova, Berkend Pura
Community Development Projects In Moldova, Berkend Pura
Capstone Collection
This Independent Practitioner Inquiry Capstone (IPIC) aims to provide relevant information, from a Peace Corps (PC) Volunteer (PCV) standpoint, on a renovation project that was implemented in the village of Vorniceni, Republic of Moldova. At its core, this was a community development project that involved the active participation of the community of Vorniceni, providing local resources and knowledge towards the goal of building a healthier sanitation facility on the second floor of the local kindergarten.
The results of this effort indicate that the involvement of the client (people) is crucial to sucess in implementing projects, and it also shows that …
What 2017 Holds For Technology In Dentistry, Arshi Siddiqui
What 2017 Holds For Technology In Dentistry, Arshi Siddiqui
Honors College Theses
Dentistry in the United States is a field that grows and expands based on the needs of its consumers. This paper aims to highlight this very versatility through the analysis of specific demographics of dental practitioners, consumers, and the changes in technology that are predicted for the future of dentistry. With the rise of Generation X and the Millennial Generation, dentistry will undergo many changes alongside the rise of technology throughout the recent years. More evidently, the population is undergoing a very seismic shift in the way they view themselves. Because people are harboring more of an individualistic mindset, the …
Interhospital Transfer Before Thrombectomy Is Associated With Delayed Treatment And Worse Outcome In The Stratis Registry (Systematic Evaluation Of Patients Treated With Neurothrombectomy Devices For Acute Ischemic Stroke)., Michael T Froehler, Jeffrey L Saver, Osama O Zaidat, Reza Jahan, Mohammad Ali Aziz-Sultan, Richard P Klucznik, Diogo C Haussen, Frank R Hellinger, Dileep R Yavagal, Tom L Yao, David S Liebeskind, Ashutosh P Jadhav, Rishi Gupta, Ameer E Hassan, Coleman O Martin, Hormozd Bozorgchami, Ritesh Kaushal, Raul G Nogueira, Ravi H Gandhi, Eric C Peterson, Shervin R Dashti, Curtis A Given, Brijesh P Mehta, Vivek Deshmukh, Sidney Starkman, Italo Linfante, Scott H Mcpherson, Peter Kvamme, Thomas J Grobelny, Muhammad S Hussain, Ike Thacker, Nirav Vora, Peng Roc Chen, Stephen J Monteith, Robert D Ecker, Clemens M Schirmer, Eric Sauvageau, Alex Abou-Chebl, Colin P Derdeyn, Lucian Maidan, Aamir Badruddin, Adnan H Siddiqui, Travis M Dumont, Abdulnasser Alhajeri, M Asif Taqi, Khaled Asi, Jeffrey Carpenter, Alan Boulos, Gaurav Jindal, Ajit S Puri, Rohan Chitale, Eric M Deshaies, David H Robinson, David F Kallmes, Blaise W Baxter, Mouhammad A Jumaa, Peter Sunenshine, Aniel Majjhoo, Joey D English, Shuichi Suzuki, Richard D Fessler, Josser E Delgado Almandoz, Jerry C Martin, Nils H Mueller-Kronast
Interhospital Transfer Before Thrombectomy Is Associated With Delayed Treatment And Worse Outcome In The Stratis Registry (Systematic Evaluation Of Patients Treated With Neurothrombectomy Devices For Acute Ischemic Stroke)., Michael T Froehler, Jeffrey L Saver, Osama O Zaidat, Reza Jahan, Mohammad Ali Aziz-Sultan, Richard P Klucznik, Diogo C Haussen, Frank R Hellinger, Dileep R Yavagal, Tom L Yao, David S Liebeskind, Ashutosh P Jadhav, Rishi Gupta, Ameer E Hassan, Coleman O Martin, Hormozd Bozorgchami, Ritesh Kaushal, Raul G Nogueira, Ravi H Gandhi, Eric C Peterson, Shervin R Dashti, Curtis A Given, Brijesh P Mehta, Vivek Deshmukh, Sidney Starkman, Italo Linfante, Scott H Mcpherson, Peter Kvamme, Thomas J Grobelny, Muhammad S Hussain, Ike Thacker, Nirav Vora, Peng Roc Chen, Stephen J Monteith, Robert D Ecker, Clemens M Schirmer, Eric Sauvageau, Alex Abou-Chebl, Colin P Derdeyn, Lucian Maidan, Aamir Badruddin, Adnan H Siddiqui, Travis M Dumont, Abdulnasser Alhajeri, M Asif Taqi, Khaled Asi, Jeffrey Carpenter, Alan Boulos, Gaurav Jindal, Ajit S Puri, Rohan Chitale, Eric M Deshaies, David H Robinson, David F Kallmes, Blaise W Baxter, Mouhammad A Jumaa, Peter Sunenshine, Aniel Majjhoo, Joey D English, Shuichi Suzuki, Richard D Fessler, Josser E Delgado Almandoz, Jerry C Martin, Nils H Mueller-Kronast
Articles, Abstracts, and Reports
BACKGROUND: Endovascular treatment with mechanical thrombectomy (MT) is beneficial for patients with acute stroke suffering a large-vessel occlusion, although treatment efficacy is highly time-dependent. We hypothesized that interhospital transfer to endovascular-capable centers would result in treatment delays and worse clinical outcomes compared with direct presentation.
METHODS: STRATIS (Systematic Evaluation of Patients Treated With Neurothrombectomy Devices for Acute Ischemic Stroke) was a prospective, multicenter, observational, single-arm study of real-world MT for acute stroke because of anterior-circulation large-vessel occlusion performed at 55 sites over 2 years, including 1000 patients with severe stroke and treated within 8 hours. Patients underwent MT with or …
Culturally Tailored Cancer Communication, Education, And Research: The Highways And Back Roads Of Appalachia, Kelly A. Dorgan, Sadie P. Hutson, Abigail Gerding, Katie L. Duvall
Culturally Tailored Cancer Communication, Education, And Research: The Highways And Back Roads Of Appalachia, Kelly A. Dorgan, Sadie P. Hutson, Abigail Gerding, Katie L. Duvall
Kelly A. Dorgan
We have varying experiences with Appalachia, yet we all agree that there is a unique relationship between Appalachians and cancer. Two of us are nurses who have worked with various communities. Two of us grew up here; 1 watched several of her relatives battle cancer in their Appalachian homes. All of us are scholars who want to talk with practitioners and researchers who are developing culturally tailored cancer control interventions. This goal to have a dialogue emerged after we had a series of discussions about cancer in Appalachia, discussions resulting in our developing a list of cultural traits that seem …
Neuronal Correlates For Neuroendocrine Habituation To Repeated Stress, Sara Matovic
Neuronal Correlates For Neuroendocrine Habituation To Repeated Stress, Sara Matovic
Electronic Thesis and Dissertation Repository
One way that the body actively responds to an impending stressor is by increasing systemic glucocorticoids through the activation of the hypothalamic-pituitary-adrenal (HPA) axis. While it is essential for short-term adaptation to stress, the sustained activation of the HPA axis during chronic stress can be detrimental and is linked to stress-related psychiatric conditions such as anxiety and depression. Therefore, it is important that the HPA axis adapts, or habituates, during chronic stress to minimize the negative consequences. Corticotropin releasing hormone (CRH) neurons in the paraventricular nucleus of the hypothalamus (PVN) function to assimilate incoming information from the stress circuitry and …
Coevolving Residues And The Expansion Of Substrate Permissibility In Laglidadg Homing Endonucleases, Thomas A. Mcmurrough
Coevolving Residues And The Expansion Of Substrate Permissibility In Laglidadg Homing Endonucleases, Thomas A. Mcmurrough
Electronic Thesis and Dissertation Repository
Genome-editing (GE) is a form of genetic engineering that permits the deliberate manipulation of genetic material for the study of biological processes, agricultural and industrial biotechnologies, and developing targeted therapies to cure human disease. While the potential application of GE is wide-ranging, the efficacy of most strategies is dependent upon the ability to accurately introduce a double-stranded break at the genomic location where alterations are desired. LAGLIDADG homing endonucleases (LHEs) are a class of mobile genetic element that recognize and cleave 22-bp sequences of DNA. Given this high degree of specificity, LHEs are powerful GE reagents, …
Navigating Occupation And Identity In Parkinson's Disease: A Qualitative Exploration Of Lived Experience, Sara G. Lutz
Navigating Occupation And Identity In Parkinson's Disease: A Qualitative Exploration Of Lived Experience, Sara G. Lutz
Electronic Thesis and Dissertation Repository
Evidence-based practice requires that health care providers interpret the best research evidence in the context of their clinical experience, while at the same time considering client knowledge and experiences. Although health care providers are becoming increasingly skilled at the evaluation of research evidence, client values and self-identified health issues are often neglected within the evidence-based practice process. Ignoring these key aspects of person-centered practice may lead to interventions that fail to target implications of a client’s disease that are important to occupational participation and quality of life. A focus on person-centeredness is particularly important in progressive neurodegenerative disorders such as …
Vietnamese American Women’S Beliefs And Perceptions On Cervical Cancer, Cervical Cancer Screening, And Cancer Prevention Vaccines: A Community-Based Participatory Study, Connie Kim Yen Nguyen-Truong, Kim Quy Vo Nguyen, Thai Hien Nguyen, Tuong Vy Le, Anthony My Truong, Keara Rodela, Rachael Allan
Vietnamese American Women’S Beliefs And Perceptions On Cervical Cancer, Cervical Cancer Screening, And Cancer Prevention Vaccines: A Community-Based Participatory Study, Connie Kim Yen Nguyen-Truong, Kim Quy Vo Nguyen, Thai Hien Nguyen, Tuong Vy Le, Anthony My Truong, Keara Rodela, Rachael Allan
Asian/Pacific Island Nursing Journal
Cervical cancer remains commonly diagnosed in Vietnamese American women. Despite efforts to increase cervical cancer screening among Vietnamese American women, participation rates are persistently lower than the national goal. The objective of this study is to explore beliefs of Vietnamese American women about cervical cancer, cervical cancer screening, and cancer prevention vaccines. A qualitative descriptive investigation captured group perceptions about meaning and beliefs of cervical cancer, screening, and cancer prevention vaccines, and participants’ stories using a community-based participatory research approach.
Forty Vietnamese American women were recruited from the Portland, Oregon metropolitan area into four focus groups. Using a process of …
Perceptions Of Emr Documentation In The Home Setting, Catherine Hupf
Perceptions Of Emr Documentation In The Home Setting, Catherine Hupf
Applied Research Projects
The use of technology in healthcare is ever increasing in our hospitals, doctor’s offices, and clinics. Studies have been done to ascertain the perceptions of patients on the use of technology in the places that provide them care. This project was done for a population that does not always receive care where the clinician is. The care is in their home by clinicians who are using laptop computers and documenting in the EMR. Home care and hospice patients or their caregivers were asked to complete a survey with seven questions scored with a 5-point Likert scale to find that they …
The Analytical Methods Used To Detect Fluoride In Dental Pharmaceuticals, Amber Aboona
The Analytical Methods Used To Detect Fluoride In Dental Pharmaceuticals, Amber Aboona
Honors College Theses
My thesis, “The Analytical Methods Used to Detect Fluoride in Dental Pharmaceuticals” discusses the various analytical chemistry methods which are incorporated in the field of dentistry in order to detect fluoride in pharmaceuticals such as toothpaste and mouthwash. The oral cavity is exposed to various forms of bacteria, many of which enter through the consumption of foods and drinks that contain sugar and starch. The side effects of fluoride have been a controversial component of oral healthcare, however, many benefits have been discussed. Water fluoridation has been one of many significant methods of incorporating fluoride into the oral cavity, enhancing …
Iron Reduction Response And Demographic Differences Between Diabetics And Non-Diabetics With Cardiovascular Disease Entered To A Controlled Clinical Trial, Leo Zacharski, Galina Shamayeva, Bruce Chow
Iron Reduction Response And Demographic Differences Between Diabetics And Non-Diabetics With Cardiovascular Disease Entered To A Controlled Clinical Trial, Leo Zacharski, Galina Shamayeva, Bruce Chow
Dartmouth Scholarship
Iron-catalyzed oxygen free radical-induced oxidative stress mediates the pathogenesis of diabetes and cardiovascular disease (CVD). Diabetics (n=473) and non-diabetics (n=804) with CVD entered to a randomized trial of iron (ferritin) reduction by calibrated phlebotomy (www.clinicaltrials.gov, Identifier NCT00032357) had comparable iron measures at entry but diabetics had greater burden of CVD and comorbidities, lower hemoglobin and hematocrit levels, and higher glucose levels than non-diabetics. Entry iron measures were lower in diabetics on hypoglycemic therapy compared to diabetics untreated previously. Diabetics and non-diabetics had comparable iron measures during follow-up. Loess analysis of paired ferritin and hemoglobin, and paired ferritin and glucose levels …
Test Anxiety And Undergraduate Nursing Students: The Concept, Impact, And Interventions, Sarah Macadam
Test Anxiety And Undergraduate Nursing Students: The Concept, Impact, And Interventions, Sarah Macadam
The University Honors Program
Test anxiety in undergraduate nursing students negatively impacts test scores and overall academic success. This project utilizes current literature to identify the concept of test anxiety, the impact of test anxiety on undergraduate nursing students, and interventions to help reduce test anxiety. Literature findings will then be included in an educational PowerPoint presentation given to an undergraduate nursing course at Wright State University.
What's Happening: December 11, 2017, Maine Medical Center
What's Happening: December 11, 2017, Maine Medical Center
What's Happening
No abstract provided.
Structural And Functional Insights Into The Role Of Bamd And Bame Within The Β-Barrel Assembly Machinery In Neisseria Gonorrhoeae, Aleksandra E. Sikora, Igor H. Wierzbicki, Ryszard A. Zielke, Rachael F. Ryner, Konstantin V. Korotkov, Susan K. Buchanan, Nicholas Noinaj
Structural And Functional Insights Into The Role Of Bamd And Bame Within The Β-Barrel Assembly Machinery In Neisseria Gonorrhoeae, Aleksandra E. Sikora, Igor H. Wierzbicki, Ryszard A. Zielke, Rachael F. Ryner, Konstantin V. Korotkov, Susan K. Buchanan, Nicholas Noinaj
Molecular and Cellular Biochemistry Faculty Publications
The β-barrel assembly machinery (BAM) is a conserved multicomponent protein complex responsible for the biogenesis of β-barrel outer membrane proteins (OMPs) in Gram-negative bacteria. Given its role in the production of OMPs for survival and pathogenesis, BAM represents an attractive target for the development of therapeutic interventions, including drugs and vaccines against multidrug-resistant bacteria such as Neisseria gonorrhoeae. The first structure of BamA, the central component of BAM, was from N. gonorrhoeae, the etiological agent of the sexually transmitted disease gonorrhea. To aid in pharmaceutical targeting of BAM, we expanded our studies to BamD and BamE within …
Association Between Left Ventricular Mechanics And Diffuse Myocardial Fibrosis In Patients With Repaired Tetralogy Of Fallot: A Cross-Sectional Study, Christopher M. Haggerty, Jonathan D. Suever, Arichanah Pulenthiran, Abba Mejia-Spiegeler, Gregory J. Wehner, Linyuan Jing, Richard J. Charnigo, Brandon K. Fornwalt, Mark A. Fogel
Association Between Left Ventricular Mechanics And Diffuse Myocardial Fibrosis In Patients With Repaired Tetralogy Of Fallot: A Cross-Sectional Study, Christopher M. Haggerty, Jonathan D. Suever, Arichanah Pulenthiran, Abba Mejia-Spiegeler, Gregory J. Wehner, Linyuan Jing, Richard J. Charnigo, Brandon K. Fornwalt, Mark A. Fogel
Biomedical Engineering Faculty Publications
Background: Patients with repaired tetralogy of Fallot (TOF) have progressive, adverse biventricular remodeling, leading to abnormal contractile mechanics. Defining the mechanisms underlying this dysfunction, such as diffuse myocardial fibrosis, may provide insights into poor long-term outcomes. We hypothesized that left ventricular (LV) diffuse fibrosis is related to impaired LV mechanics.
Methods: Patients with TOF were evaluated with cardiac magnetic resonance in which modified Look-Locker (MOLLI) T1-mapping and spiral cine Displacement encoding (DENSE) sequences were acquired at three LV short-axis positions. Linear mixed modeling was used to define the association between regional LV mechanics from DENSE based on regional T1-derived diffuse …
Ionis Drug Successfully Reduces Toxic Huntington’S Disease Protein, Paving Way For Phase 2 Trial Of Effect On Patients, Kenneth P. Serbin
Ionis Drug Successfully Reduces Toxic Huntington’S Disease Protein, Paving Way For Phase 2 Trial Of Effect On Patients, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Genetic Epidemiology Of Neural Tube Defects, Philip J Lupo, A J Agopian, Heidi Castillo, Jonathan Castillo, Gerald H Clayton, Nienke P Dosa, Betsy Hopson, David B Joseph, Brandon G Rocque, William O Walker, John S Wiener, Laura E Mitchell
Genetic Epidemiology Of Neural Tube Defects, Philip J Lupo, A J Agopian, Heidi Castillo, Jonathan Castillo, Gerald H Clayton, Nienke P Dosa, Betsy Hopson, David B Joseph, Brandon G Rocque, William O Walker, John S Wiener, Laura E Mitchell
Journal Articles
It has been estimated that 60-70% of neural tube defects (NTDs) have a genetic component, but few causative genes have been identified. The lack of information on genes associated with non-syndromic NTDs in humans is especially notable as the "genomic revolution" has led to new tools (e.g., genome-wide genotyping arrays, next-generation sequencing) that are helping to elucidate the full spectrum of genetic variation (from common to rare) contributing to complex traits, including structural birth defects. However, the application of modern genomic approaches to the study of NTDs has lagged behind that of some other common structural birth defects. This may …
Aging, Inflammation, And Gut Microbiota In Mice, Jody Demeo
Aging, Inflammation, And Gut Microbiota In Mice, Jody Demeo
Honors Projects
Inflammation and gut microbiota are two areas of study that can be linked to aging in the body. As a person ages, systemic inflammation tends to increase, and changes in microbiota in the gastrointestinal system occur as well.