Medicine and Health Sciences Commons^™

Neuronal Correlates For Neuroendocrine Habituation To Repeated Stress, Sara Matovic

Electronic Thesis and Dissertation Repository

One way that the body actively responds to an impending stressor is by increasing systemic glucocorticoids through the activation of the hypothalamic-pituitary-adrenal (HPA) axis. While it is essential for short-term adaptation to stress, the sustained activation of the HPA axis during chronic stress can be detrimental and is linked to stress-related psychiatric conditions such as anxiety and depression. Therefore, it is important that the HPA axis adapts, or habituates, during chronic stress to minimize the negative consequences. Corticotropin releasing hormone (CRH) neurons in the paraventricular nucleus of the hypothalamus (PVN) function to assimilate incoming information from the stress circuitry and …

Self-Management As A Mediator Of The Relationship Between Social Support And Health Outcomes Of African American Adults With Type 2 Diabetes., Tariq N. Al-Dwaikat

Electronic Theses and Dissertations

Type 2 diabetes (T2D) is often associated with serious complications. African American adults have higher rates of diabetes-related complications than other ethnicities. Diabetes self-management reduces the risk of developing biological and psychological symptoms. Social support promotes positive behavior change and self-management that leads to improved biobehavioral and psychosocial outcomes. Few studies explored the relationship between social support dimensions and self-management behaviors, diabetes biomarkers, and psychosocial outcomes of African American adults with T2D. The purpose of this dissertation was to examine the relationships of various dimensions of social support with self-management behaviors and diabetes biomarkers and psychosocial outcomes of African American …

The Eating Habits Of College Females And How Stress Affects Eating Behavior, Rachel Russom, Abigail Fontenot

Dietetics and Nutrition Class Publications

Background College females experience much stress from a variety of areas in their lives. Often times this stress affects usual eating behaviors and may even lead to disordered eating habits.

Objectives To examine whether stress affects the eating habits of college females in this study and how their eating is affected. We assumed that stress would affect eating habits. We also examined how stress makes a person a feel and if that can influence or contribute to disordered eating habits.

Participants/setting Sixty-two women from Tri-Chi women’s social club at Ouachita Baptist University completed a questionnaire October 16, 2017. The participants …

The Dynamics Of Stress And Fatigue Across Menopause: Attractors, Coupling, And Resilience, Lisa Taylor-Swanson, Alexander E. Wong, David Pincus, Jonathan E. Butner, Jennifer Hahn-Holbrook, Mary Koithan, Kathryn Wann, Nancy F. Woods

Psychology Faculty Articles and Research

Objective:

The objective of this study was to evaluate the regulatory dynamics between stress and fatigue experienced by women during the menopausal transition (MT) and early postmenopause (EPM). Fatigue and perceived stress are commonly experienced by women during the MT and EPM. We sought to discover relationships between these symptoms and to employ these symptoms as possible markers for resilience.

Methods:

Participants were drawn from the longitudinal Seattle Midlife Women's Health Study. Eligible women completed questionnaires on 60+ occasions (annual health reports and monthly health diaries) (n = 56 women). The total number of observations across the sample was 4,224. …

Law Library Blog (November 2017): Legal Beagle's Blog Archive, Roger Williams University School Of Law

Law Library Newsletters/Blog

No abstract provided.

Corticosterone Regulates Both Naturally Occurring And Cocaine‐Induced Dopamine Signaling By Selectively Decreasing Dopamine Uptake, Daniel S. Wheeler, Amanda L. Ebben, Beliz Kurtoglu, Marissa E. Lovell, Austin T. Bohn, Isabella A. Jasek, David A. Baker, John R. Mantsch, Paul J. Gasser, Robert A. Wheeler

Biomedical Sciences Faculty Research and Publications

Stressful and aversive events promote maladaptive reward‐seeking behaviors such as drug addiction by acting, in part, on the mesolimbic dopamine system. Using animal models, data from our laboratory and others show that stress and cocaine can interact to produce a synergistic effect on reward circuitry. This effect is also observed when the stress hormone corticosterone is administered directly into the nucleus accumbens (NAc), indicating that glucocorticoids act locally in dopamine terminal regions to enhance cocaine's effects on dopamine signaling. However, prior studies in behaving animals have not provided mechanistic insight. Using fast‐scan cyclic voltammetry, we examined the effect of systemic …

Social Status Modulates Restraint- Induced Neural Activity In Brain Regions Controlling Stress Vulnerability , Sahba Seddighi, Matthew A. Cooper

Haslam Scholars Projects

Understanding the cellular mechanisms that control resistance and vulnerability to stress is an important step toward identifying novel targets for the prevention and treatment of stress-related mental illness. Dominant and subordinate animals have been shown to exhibit different behavioral and physiological responses to stress, with dominants often showing stress resistance and subordinates often showing stress vulnerability. We have previously found that dominant hamsters exhibit reduced social avoidance following social defeat stress compared to subordinate hamsters, although the extent to which stress resistance in dominants generalizes to non-social stressors is unknown. In this study, dominant, subordinate, and control male Syrian hamsters …

Mindfulness-Based Stress Reduction Lowers Psychological Distress In Medical Students, Steven Rosenzweig Md, Diane K. Reibel, Jeffrey M. Greeson, George C. Brainard, Mohammadreza Hojat

Jeffrey M. Greeson

Background: Medical students confront significant academic, psychosocial, and existential stressors throughout their training. Mindfulness-based stress reduction (MBSR) is an educational intervention designed to improve coping skills and reduce emotional distress. Purpose: The purpose of this study was to examine the effectiveness of the MBSR intervention in a prospective, nonrandomized, cohort-controlled study. Methods: Second-year students (n = 140) elected to participate in a 10-week MBSR seminar. Controls (n = 162) participated in a didactic seminar on complementary medicine. Profile of Mood States (POMS) was administered preintervention and postintervention. Results: Baseline total mood disturbance (TMD) was greater in the MBSR group compared …

Mindfulness-Based Stress Reduction And Health-Related Quality Of Life In A Heterogeneous Patient Population, Diane K. Reibel, Jeffrey M. Greeson, George C. Brainard, Steven Rosenzweig Md

Jeffrey M. Greeson

This study examined the effects of mindfulness-based stress reduction (MBSR) on health-related quality of life and physical and psychological symptomatology in a heterogeneous patient population. Patients (n=136) participated in an 8-week MBSR program and were required to practice 20 min of meditation daily. Pre- and post-intervention data were collected by using the Short-Form Health Survey (SF-36), Medical Symptom Checklist (MSCL) and Symptom Checklist-90 Revised (SCL-90-R). Health-related quality of life was enhanced as demonstrated by improvement on all indices of the SF-36, including vitality, bodily pain, role limitations caused by physical health, and social functioning (all P<.01). Alleviation of physical …

Anger Without Agency: Exploring The Experiences Of Stress In Adolescent Girls, Elin A. Björling, Narayan B. Singh

The Qualitative Report

Although a great deal of research has measured stressful life events and stress-related symptoms in adolescents, little research has qualitatively examined the experience of stress in teens. The purpose of this study was to utilize thematic analysis to explore how teen girls described their experiences of stress. Thirty-one girls, ages 14–18, were recruited for a study examining stress and stress-related symptoms. As part of this study, they participated in an open-ended, qualitative interview about their personal experiences of stress. Themes included the mind of stress, emotionally shutting out others, and “growing out of it.” The overarching finding was that all …

Developmental Lead And/Or Prenatal Stress Exposures Followed By Different Types Of Behavioral Experience Result In The Divergence Of Brain Epigenetic Profiles In A Sex, Brain Region, And Time-Dependent Manner: Implications For Neurotoxicology., Deborah A. Cory-Slechta, Marissa Sobolewski, Garima Varma, Jay S. Schneider

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Over a lifetime, early developmental exposures to neurocognitive risk factors, such as lead (Pb) exposures and prenatal stress (PS), will be followed by multiple varied behavioral experiences. Pb, PS and behavioral experience can each influence brain epigenetic profiles. Our recent studies show a greater level of complexity, however, as all three factors interact within each sex to generate differential adult variation in global post-translational histone modifications (PTHMs), which may result in fundamentally different consequences for life-long learning and behavioral function. We have reported that PTHM profiles differ by sex, brain region and time point of measurement following developmental exposures to …

Perceived Stress Levels May Impact Upper Extremity Function Among Women Treated For Breast Cancer, Mary Insana Fisher, Anne Fleischer, Kimbery Parent, Renee Roberts, Megan Mcclure, Lynn Hendricks

EKU Faculty and Staff Scholarship

Women treated for breast cancer report ongoing disability in their involved upper extremity, however, often objective measures do not appear to explain the level of perceived dysfunction. The purpose of this study was to investigate the relationship between perceived stress level, fear of physical activity and self-reported upper extremity function among women treated for breast cancer.

Stress Exposure And Physical, Mental, And Behavioral Health Among American Indian Adults With Type 2 Diabetes, Melissa L. Walls, Kelley J. Sittner, Benjamin D. Aronson, Angie K. Forsberg, Les B. Whitbeck, Mustafa Al'absi

Pharmacy Faculty Scholarship

American Indian (AI) communities experience disproportionate exposure to stressors and health inequities including type 2 diabetes. Yet, we know little about the role of psychosocial stressors for AI diabetes-related health outcomes. We investigated associations between a range of stressors and psychological, behavioral, and physical health for AIs with diabetes. This community-based participatory research with 5 AI tribes includes 192 AI adult type 2 diabetes patients recruited from clinical records at tribal clinics. Data are from computer-assisted interviews and medical charts. We found consistent bivariate relationships between chronic to discrete stressors and mental and behavioral health outcomes; several remained even after …

Sources Of Medical Student Stress, Krishna Subhash Vyas, Terry D. Stratton, Neelkamal S. Soares

Behavioral Science Faculty Publications

Background: Key elements in the clinical practice of prevention, health and wellness are best cultivated in medical professionals during undergraduate medical training. This study explores students' self-assessed stress relative to gender, academic expectations, and level of medical training to guide development of targeted wellness interventions. Methods: In early 2012, undergraduate (M1-M4) students in four Southeastern U.S. allopathic medical schools were surveyed about health-related attitudes and behaviors. Results: A total of 575 students returned completed questionnaires. Students in the preclinical years (M1-M2), especially females, reported significantly higher stress levels. Academic expectations and satisfaction were also significantly implicated. Discussion: These findings highlight …

Oxidative Stress Biomarkers And Cardiac Troponin I In Arabian Horses With Strangles, Wael M. El-Deeb, Ahmed M. Elmoslemany

The Thai Journal of Veterinary Medicine

In order to investigate the levels of oxidative stress (OS) biomarkers and cardiac troponin I (cTnI) in horses with strangles, fifty horses with strangles and twenty healthy controls were included in this study. Blood and serum samples were tested for levels of cardiac troponin I (cTnI), malondialdehyde (MDA), super oxide dismutase (SOD), glutathione (GSH), nitric oxide (NO) and total antioxidant capacity (TAC). The levels of cTnI were increased in ten diseased cases while normal cTnI levels were found in the others (n=40). The levels of MDA were increased in the horses with strangles when compared with the healthy ones. The …

General Nutrition Knowledge And Perceived Stress In A Rural Female Faith Community, Lori Alexander, M. Laurie Branstetter Dnp

International Journal of Faith Community Nursing

In rural America, high rates of obesity are influenced by a lack of education and limited community resources. The purpose of this study was to assess the effect of an educational intervention on recommended nutrition and body mass index knowledge and to describe the perceived stress in a rural female faith community. A quantitative quasi-experimental pre-test post-test research design was used. English speaking female participants (N=49) 18 years of age and older from two rural community churches received an educational intervention based on the Health Belief Model. Participants completed a demographic survey, self-reported height and weight, general nutrition …

Factors Associated With Stress Among Adolescents In The City Of Nawabshah, Pakistan., Yasmin Parpio, Salima Farooq, Saleema Gulzar, Ambreen Tharani, Tazeen Saeed Ali, Fawad Javed

Ambreen Tharani

OBJECTIVE: To identify the risk factors of stress among school-going adolescents in rural Nawabshah, Pakistan. METHODS: The cross-sectional study was conducted in 2005, comprising 800 school-going children of 10-16 years of age in Nawabshah, through simple random sampling. Data was collected using a structured questionnaire to assess the potential risk factors of stress. A modified version of Perceived stress scale was utilized to measure stress level. SPSS 12 was used for statistical analysis, while multiple linear regression analysis was run to identify the factors associated with stress in the study population. RESULTS: Of the total, 529 (66%) children belonged to …

Resilience And Coping In The Adolescent And Young Adult With Type 1 Diabetes, Debra L. Messinger

Seton Hall University Dissertations and Theses (ETDs)

There is a need to understand the roles coping strategies play in enhancing resilience in adolescents and young adults with type 1 diabetes between the ages of 18-30. The purpose of this study was to examine the relationships between and among positive, protective coping strategies (courageous coping), negative coping strategies (defensive coping), and resilience. The Resilience in Illness Model (Haase, Kinter, Monahan, & Robb, 2014) was the theoretical model which guided this research.

A convenience sample was recruited via diabetes organizations’ Facebook and Forum pages, a College Diabetes Network chapter meeting, and Juvenile Diabetes Research Foundations’ (JDRF) sponsored events. Data …

Tia1 Mutations In Amyotrophic Lateral Sclerosis And Frontotemporal Dementia Promote Phase Separation And Alter Stress Granule Dynamics., Ian R. Mackenzie, Alexandra M. Nicholson, Mohona Sarkar, James Messing, Maria D. Purice, Cyril Pottier, Kavya Annu, Matt Baker, Ralph B. Perkerson, Aishe Kurti, Billie J. Matchett, Tanja Mittag, Jamshid Temirov, Ging-Yuek R. Hsiung, Charles Krieger, Melissa E. Murray, Masato Kato, John D. Fryer, Leonard Petrucelli, Lorne Zinman, Sandra Weintraub, Marsel Mesulam, Julia Keith, Sasha A. Zivkovic, Veronica Hirsch-Reinshagen, Raymond P. Roos, Stephan Züchner, Neill R. Graff-Radford, Ronald C. Petersen, Richard J. Caselli, Zbigniew K. Wszolek, Elizabeth Finger, Carol Lippa, David Lacomis, Heather Stewart, Dennis W. Dickson, Hong Joo Kim, Ekaterina Rogaeva, Eileen Bigio, Kevin B. Boylan, J. Paul Taylor, Rosa Rademakers

Department of Neurology Faculty Papers

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are age-related neurodegenerative disorders with shared genetic etiologies and overlapping clinical and pathological features. Here we studied a novel ALS/FTD family and identified the P362L mutation in the low-complexity domain (LCD) of T cell-restricted intracellular antigen-1 (TIA1). Subsequent genetic association analyses showed an increased burden of TIA1 LCD mutations in ALS patients compared to controls (p = 8.7 × 10

Stress Increases Peripheral Axon Growth And Regeneration Through Glucocorticoid Receptor-Dependent Transcriptional Programs, Jessica K. Lerch, Jessica K. Alexander, Kathryn M. Madalena, Dario Motti, Tam Quach, Akhil Dhamija, Alicia Zha, John C. Gensel, Jeanette Webster Marketon, Vance P. Lemmon, John L. Bixby, Phillip G. Popovich

Physiology Faculty Publications

Stress and glucocorticoid (GC) release are common behavioral and hormonal responses to injury or disease. In the brain, stress/GCs can alter neuron structure and function leading to cognitive impairment. Stress and GCs also exacerbate pain, but whether a corresponding change occurs in structural plasticity of sensory neurons is unknown. Here, we show that in female mice (Mus musculus) basal GC receptor (Nr3c1, also known as GR) expression in dorsal root ganglion (DRG) sensory neurons is 15-fold higher than in neurons in canonical stress-responsive brain regions (M. musculus). In response to stress or GCs, adult …

Age Differences In Stress And Coping: Problem-Focused Strategies Mediate The Relationship Between Age And Positive Affect, Yiwei Chen, Yisheng Peng, Huanzhen Xu, William H. O'Brien

Psychology Faculty Publications

The present study examined the different types of stressors experienced by adults of different ages, their coping strategies, and positive/negative affect. A mediation hypothesis of coping strategies was tested on the relationships between age and positive/negative affect. One-hundred and ninety-six community-dwelling adults (age range 18-89 years old) reported the most stressful situation they experienced in the past month and coping strategies. Levels of positive and negative affect in the past month were also measured. Content analysis revealed age differences in different types of stressors adults reported. Three types of coping strategies were found: problem-focused, positive emotion-focused, and negative emotion-focused coping. …

Mindfulness-Based Stress Reduction In Women With Overweight Or Obesity: A Randomized Clinical Trial., Nazia Raja-Khan, Katrina Agito, Julie Shah, Christy M Stetter, Theresa S Gustafson, Holly Socolow, Allen R Kunselman, Diane K. Reibel, Richard S Legro

Marcus Institute of Integrative Health Faculty Papers

OBJECTIVE: To evaluate the feasibility and cardiometabolic effects of mindfulness-based stress reduction (MBSR) in women with overweight or obesity.

METHODS: Eighty-six women with BMI ≥ 25 kg/m

RESULTS: Compared to health education, the MBSR group demonstrated significantly improved mindfulness at 8 weeks (mean change from baseline, 4.5 vs. -1.0; P = 0.03) and significantly decreased perceived stress at 16 weeks (-3.6 vs. -1.3, P = 0.01). In the MBSR group, there were significant reductions in fasting glucose at 8 weeks (-8.9 mg/dL, P = 0.02) and at 16 weeks (-9.3 mg/dL, P = 0.02) compared to baseline. Fasting glucose did …

A Grounded Theory Inquiry Into Crying In Women Dealing With The Emotional Stress Of Personal Crisis, Mary Bess Griffith

Doctoral Dissertations

The belief that crying leads to healing is so widely held and of such longstanding that many healthcare professionals—including nurses, physicians, psychiatrists, and psychologists—accept it as fact even though there is little substantiating scientific evidence. Crying is commonly believed to be an essential factor in restoring mind-body equilibrium after physical and/or emotional trauma has been experienced. If, as has been hypothesized by many scientists and healthcare practitioners, emotional crying is a biopsychosocial healing modality, then specifics of its therapeutic praxis, including limitations and ambiguities, should be incorporated into nursing education and practice. In this grounded theory study, the meaning and …

Long Working Hours And Occupational Stress-Related Illness And Injury: Mini Review, Harrynauth Persaud, Shawn Williams

Publications and Research

Workplace injuries and illnesses have been associated with long working hours. In the United States, working overtime has been on the rise. It is estimated that American workers spend an extra 1.5 hours per week at their job, and for those working in manufacturing-overtime has increased by 25% when compared to 10 years ago. Data suggests that working greater than 12 hours in a single day was associated with a 37% (95% CI=1.16–1.59) increase in hazard rate (HR), while working greater than 60 hour per week was associated with a 23% (95% CI=1.05–1.45) increase in HR. For those working overtime, …

The Whole Is Not The Sum Of Its Parts: Specific Types Of Positive Affect Influence Sleep Differentially, Sarah D. Pressman, Brooke N. Jenkins, Tara L. Kraft, Heather Rasmussen, Michael F. Scheier

Psychology Faculty Articles and Research

Given the known detrimental effects of poor sleep on an array of psychological and physical health processes, it is critical to understand the factors that protect sleep, especially during times of stress when sleep particularly suffers. Positive affect (PA) arises as a variable of interest given its known associations with health and health behaviors and its ability to buffer stress. In two studies, we examined which types of PA (distinguished by arousal level and trait/state measurement) were most beneficial for sleep and whether these associations varied depending on the stress context. In Study 1, college students (N = 99) reported …

Sibrava Studies, Teaches About Stress And Anxiety, Aldemaro Romero Jr.

Publications and Research

“There’s a cliché answer that you get from a lot of folks who say, ‘Well, I’ve always been interested in people,’ and that is true, but for me I always fan- tasized about being a lawyer when I grew up.” This is how Dr. Nicholas Sibrava explains his choice of career. In fact, he envisioned himself in a courtroom, just like in the movies.

It also explains why this native of Cleveland, Ohio obtained a bachelor’s degree in both criminology and psychology. The psychology part crept up on him while taking some psych courses. “Somewhere along the way I flip-flopped …

Resiliency In The Operating Room: Exploring Trainee Stress During Surgery And The Role Of Individual Resilience, Richard Ng

Electronic Thesis and Dissertation Repository

Surgical trainees experience significant intraoperative stress, which can negatively impact performance and learning. Psychological resilience suggests why some individuals excel despite severe stress. This study explores the relationship between trainee resilience and intraoperative stress. A novel instrument was developed to assess Surgical TRainee Experiences of StresS in the Operating Room (STRESSOR). Focus groups and a literature review identified eight domains of intraoperative stress. STRESSOR was used in a survey of orthopaedic residents in Canada and surgical trainees at Western University. Resiliency was assessed using the 10-item Connor-Davidson Resiliency Scale. 171 responses were received for a 38 percent response rate. The …

Factors Associated With Stress Among Adolescents In The City Of Nawabshah, Pakistan., Yasmin Parpio, Salima Farooq, Saleema Gulzar, Ambreen Tharani, Tazeen Saeed Ali, Fawad Javed

Tazeen Ali

OBJECTIVE: To identify the risk factors of stress among school-going adolescents in rural Nawabshah, Pakistan. METHODS: The cross-sectional study was conducted in 2005, comprising 800 school-going children of 10-16 years of age in Nawabshah, through simple random sampling. Data was collected using a structured questionnaire to assess the potential risk factors of stress. A modified version of Perceived stress scale was utilized to measure stress level. SPSS 12 was used for statistical analysis, while multiple linear regression analysis was run to identify the factors associated with stress in the study population. RESULTS: Of the total, 529 (66%) children belonged to …

A Web-Based Stress Reduction Program For Occupational Health, Michelle N. Kabakibi, Karen Macauley

Doctor of Nursing Practice Final Manuscripts

Purpose: The purpose of this evidenced-based practice project is to implement a sustainable 6-week mindfulness web-based program to reduce stress of call center employees in a corporate setting.

Background/significance: Stress is a major public health issue, calling for a need of better stress management programs to prevent and manage chronic stress. Stress is caused when an individual perceives environmental demands as beyond his/her adaptive capacity. In the workplace, stress leads to emotional exhaustion, job dissatisfaction, lower productivity, and impaired performance (Allexandre et al., 2016). According to The National Institute for Occupational Safety and Health report, 40% of workers reported …

Mindfulness And Law Enforcement: An Effective Approach To Implementing Mindfulness For First Responders, Gina White

Mindfulness Studies Theses

An increasing number of studies show that people employed as first responders in high trauma service jobs tend to experience a high level of stress, at work and after hours. Studies suggest that constant exposure to job related stress leads to both physical and mental dysregulation. This study looks at the effects of implementing mindfulness tools and techniques to those working in law enforcement. Other works on this topic report mindfulness as a successful tool to increase wellbeing to a broad spectrum of populations. The methodology used in this study was designed specifically for first responders. The data findings were …