Medicine and Health Sciences Commons^™

Pubh 7890 - Individual Study: Statistical Methods In Diagnostic Medicine, Jingjing Yin

College of Public Health: Faculty Syllabi (2014-2021)

This course introduces the statistical concepts and methods for designing and analyzing biomarker data for diagnostic tests.

Bios/Pubh 6541 - Biostatistics, Jingjing Yin

College of Public Health: Faculty Syllabi (2014-2021)

This 4 credit course examines statistics in public health and related sciences, including sampling, probability, basic discrete and continuous distributions, descriptive statistics, hypothesis testing, confidence intervals, categorical data analysis, regression, and correlation. Emphasis will be on the development of critical thinking skills and health data analysis applications with computer software.

Pubh 6541 - Categorical Data Analysis, Haresh Rochani

College of Public Health: Faculty Syllabi (2014-2021)

(taken from 2012-13 Course Catalog): This course introduces statistical methods for analyzing both univariate and multivariate categorical data and count in medical research and other health-related fields. The course will introduce how to distinguish among the different measurement scales, the commonly used statistical probability distribution and inference methods for categorical and count data. Emphasis will be placed on the application of the methodology and computational aspects rather than theory. The students will learn how to apply SAS procedures to data and interpret the results.

Bios 6135 - Topics Of Inference In Biostatistics, Lili Yu

College of Public Health: Faculty Syllabi (2014-2021)

(taken from 2017-18 Course Catalog): This course provides an introduction to the fundamental knowledge of derivatives, integrals, and matrix algebra found in biostatistical inference. The course will introduce the theory of quadratic forms and their applications to distributions, the method of maximum likelihood estimation, likelihood ratio tests, restricted maximum likelihood, and the basis for inferences derived from hypothesis testing and confidence intervals. Emphasis will be placed on how these techniques are used in biostatistical problems and applications using examples from the pharmaceutical industry.

Bios 7535 - Data Analysis With Sas, Robert Vogel

College of Public Health: Faculty Syllabi (2014-2021)

The class is designed to provide skill building and practical experience in using SAS to: create analysis data files; analyze data such as that found in typical biostatistical consulting problems; and assess the validity of analysis methodology assumptions. 3 credit hours.

Mathematical Modeling For Predicting Chemotherapy And Nanoparticle Treatment Efficacy In Breast Cancer, Terisse Arielle Brocato

Biomedical Engineering ETDs

Breast cancer treatment response varies by subtype, treatment regiment, and additionally by vasculature characteristics. For this reason, breast cancer is a model disease for the development of both targeted therapy and prognostic and predictive biomarkers. Mathematical modeling allows for personalized patient specific prediction of treatment outcome based on parameters found to be important to the cancer type. Mathematical modeling is beneficial in providing insight into why cancer treatment fails and in what cases, additionally determining what characteristics result in a successful treatment. Presented in Chapter 1 is a scientific introduction and discussion focusing on representative modeling works specified towards breast …

Ormeloxifene Suppresses Prostate Tumor Growth And Metastatic Phenotypes Via Inhibition Of Oncogenic Β-Catenin Signaling And Emt Progression, Bilal B. Hafeez, Aditya Ganju, Mohammed Sikander, Vivek K. Kashyap, Zubair Bin Hafeez, Neeraj Chauhan, Shabnam Malik, Andrew Massey, Manish Tripathi, Fathi T. Halaweish, Murali M. Yallapu, Subhash C. Chauhan, Meena Jaggi

School of Medicine Publications

Ormeloxifene is a clinically approved selective estrogen receptor modulator, which has also shown excellent anticancer activity, thus it can be an ideal repurposing pharmacophore. Herein, we report therapeutic effects of ormeloxifene on prostate cancer and elucidate a novel molecular mechanism of its anticancer activity. Ormeloxifene treatment inhibited epithelial-to-mesenchymal transition (EMT) process as evident by repression of N-cadherin, Slug, Snail, vimentin, MMPs (MMP2 and MMP3), β-catenin/TCF-4 transcriptional activity, and induced the expression of pGSK3β. In molecular docking analysis, ormeloxifene showed proficient docking with β-catenin and GSK3β. In addition, ormeloxifene induced apoptosis, inhibited growth and metastatic potential of prostate cancer cells and …

Elearning For Medical Educators (Elme): Pod Network 2016 Educational Development Internship Program, Gary A. Smith, Audriana Stark

Office for Medical Educator Development (OMED)

eLearning for Medical Educators (eLME) is under development as a mechanism to provide professional learning in medical education to anyone, anytime, anywhere. The project began in 2016 at the Office for Medical Educator Development within the UNM School of Medicine in order to support community faculty who host medical students and residents at their clinics. eLME was planned with numerous stakeholders using the Kirkpatrick Business Partnership Model. Two modules were delivered in early 2017 and include a combination of self-reflection, interactive multimedia, and assessment.

Las Condiciones De Vida De Los Usuarios Adultos Mayores Del Hospital Makewe / The Living Conditions Of Elderly Users Of Makewe Hospital, Taylor Selembo

Independent Study Project (ISP) Collection

Life conditions are a fundamental aspect of the health of senior citizens, as these are the factors that determine their quality of life and capacity to satisfy their needs. Life conditions are dependent on the particular social, political, economic, and geographic context of the region. This study intends to answer the following question: How are the life conditions of senior citizens belonging to Hospital Makewe, located in the IX region of Chile? This quali-quantitative study utilized observation, surveys (n = 40) and interviews (n = 15) in order to accomplish the main objective. The main objective was to describe senior …

Una Investigación Sobre La Prevalencia De La Lactancia Materna / 62/5000 An Investigation On The Prevalence Of Breastfeeding, Madeline Ferone

Independent Study Project (ISP) Collection

El propósito de la investigación es estudiar la realidad de las prácticas y la prevalencia de la lactancia materna en Chile, y cómo las características demográficas distintas de las mujeres influyen en la alimentación de sus bebés. La lactancia materna es crucial para el crecimiento y desarrollo saludable de un bebé, y también tiene beneficios para la salud de la madre. Sin embargo, las madres a menudo no siguen las pautas de la Organización Mundial de Salud y UNICEF. Los métodos de recolección de datos son una revisión de una Encuesta del Ministerio de Salud de 2013 de 9604 madres …

Inhibition Of Apoptosis Signal-Regulating Kinase 1 Alters The Wound Epidermis And Enhances Auricular Cartilage Regeneration., Qian-Shi Zhang, Deepa S. Kurpad, My G. Mahoney, Marla J. Steinbeck, Theresa A. Freeman

Department of Orthopaedic Surgery Faculty Papers

Why regeneration does not occur in mammals remains elusive. In lower vertebrates, epimorphic regeneration of the limb is directed by the wound epidermis, which controls blastema formation to promote regrowth of the appendage. Herein, we report that knockout (KO) or inhibition of Apoptosis Signal-regulated Kinase-1 (ASK1), also known as mitogen-activated protein kinase kinase kinase 5 (MAP3K5), after full thickness ear punch in mice prolongs keratinocyte activation within the wound epidermis and promotes regeneration of auricular cartilage. Histological analysis showed the ASK1 KO ears displayed enhanced protein markers associated with blastema formation, hole closure and regeneration of auricular cartilage. At seven …

The Bulletin: Sidney Kimmel Medical College At Thomas Jefferson University, Volume 66, Issue 2, Fall 2017

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

This issue includes:

• Introducing the New Jefferson: One Name. Two Legacies. Infinite Possibilities
• The PhiladelphiaU Story: A History of Change and Innovation
• Two Alumnae, One Vision: A New Home Base for All Graduates
• Second Opinions for Docs, Second Chances for Patients: The Jefferson Angioplasty Center Helps Cardiac Patients Avoid Open Heart Surgery
• Dean's Column
• Findings: Molecule May Help Maintain Brain's Synaptic Balance
• The Families We Choose: A Message from Elizabeth Dale
• On Campus
• Basil Harris, MD '02: Merging Medicine, Engineering, and Design to Revolutionize Digital Healthcare
• Big Things, Small Beginnings: Jefferson Surgeons Are Exploring New Therapies That May Make Standard …

Vitamin D Supplementation To Prevent Asthma Exacerbations: A Systematic Review And Meta-Analysis Of Individual Participant Data, David Jolliffe, Lauren Greenberg, Richard Hooper, Christopher Griffiths, Carlos Camargo Jr., Mitsuyoshi Urashima, Conor Kerley, Megan Jensen, David Mauger, Iwona Stelmach, Adrian Martineau

Articles

No abstract provided.

The Psychology Of Neurofeedback: Clinical Intervention Even If Applied Placebo, Robert T. Thibault, Amir Raz

Psychology Faculty Articles and Research

Advocates of neurofeedback make bold claims concerning brain regulation, treatment of disorders, and mental health. Decades of research and thousands of peer-reviewed publications support neurofeedback using electroencephalography (EEG-nf); yet, few experiments isolate the act of receiving feedback from a specific brain signal as a necessary precursor to obtain the purported benefits. Moreover, while psychosocial parameters including participant motivation and expectation, rather than neurobiological substrates, seem to fuel clinical improvement across a wide range of disorders, for-profit clinics continue to sprout across North America and Europe. Here, we highlight the tenuous evidence supporting EEG-nf and sketch out the weaknesses of this …

The Burden And Social Determinants Of Asthma For Adults In The State Of Georgia, Mark Ebell, Christian Marchello, Jean O'Connor

Journal of the Georgia Public Health Association

Background: Asthma is a serious chronic health condition, and social determinants may affect its prevalence.

Methods: Data from the Behavioral Risk Factors Surveillance Survey (BRFSS), the Georgia Asthma Call-back Survey (ACBS), and the Georgia hospital and emergency department survey for patients with a diagnosis of asthma were used. All data were from the years 2011 through 2014. SAS and SUDAAN software were used to calculate weighted prevalence estimates and to perform univariate and multivariate analyses of the association between social determinants, other risk factors, and asthma outcomes.

Results: The prevalence of asthma was highest among non-Hispanic blacks, women, and persons …

Optical Coherence Tomography Angiography Features Of Iris Racemose Hemangioma In 4 Cases., Jason L. Chien, Kareem Sioufi, Sandor Ferenczy, Emil Anthony T. Say, Carol L. Shields

Wills Eye Hospital Papers

Importance: Optical coherence tomography angiography (OCTA) allows visualization of iris racemose hemangioma course and its relation to the normal iris microvasculature.

Objective: To describe OCTA features of iris racemose hemangioma.

Design, Setting, and Participants: Descriptive, noncomparative case series at a tertiary referral center (Ocular Oncology Service of Wills Eye Hospital). Patients diagnosed with unilateral iris racemose hemangioma were included in the study.

Main Outcomes and Measures: Features of iris racemose hemangioma on OCTA.

Results: Four eyes of 4 patients with unilateral iris racemose hemangioma were included in the study. Mean patient age was 50 years, all patients were white, and …

An Investigation Of Human Beta-Defensins And Cathelicidin Expression In Patients With Pterygium., Remzi Karadag, Nurettin Bayram, Serpil Oguztuzun, Huseyin Bayramlar, Busra Bozer, Gulcin Simsek, Christopher J Rapuano

Wills Eye Hospital Papers

PURPOSE: To investigate human beta-defensins (HBDs) and cathelicidin LL-37 (LL-37) expressions in patients with pterygium.

METHODS: In this retrospective consecutive case series, 26 pterygium specimens and 15 normal conjunctival specimens of 15 control subjects were in vestigated. Expressions of HBD-1, HBD-2, HBD-3, and LL-37 were assessed using immuno histochemical staining. A brown color in the cytoplasm and/or nuclei of epithelial cells indicated positive staining for HBDs and LL-37. For each antibody, the intensity of the reaction (negative [-], weak [1+], moderate [2+], or strong [3+]) was determined to describe the immunoreactions.

RESULTS: The median age was 52 years in both …

Sex Differences In Intentional Exposures Among Adolescents And Adults: A Retrospective Review Of National Poison Data System (Npds) Pharmaceutical Exposures 2007-2016, Gillian A. Beauchamp Md, B Zane Horowitz Md, Esther K. Choo Md, Mph, Marna R. Greenberg Do, Mph, Facep, Daniel A. Spyker Md, Phd

Department of Emergency Medicine

No abstract provided.

Bridging The Gap From Policy To Practice: Diabetes In Rural Morocco, Zoe H. Robbin

Independent Study Project (ISP) Collection

Morocco is in the midst of an epidemiologic transition ushered in by reduced fertility rates and extended life expectancy. Unlike two decades ago, today’s leading cause of death is chronic disease. In 2006, Moroccan officials launched Vision 2020, a comprehensive plan that seeks to expand access to healthcare and reign back the prevalence of noncommunicable disease, among other goals related to development. Through qualitative interviews with the residents of Tarmilat and Oulmes, a rural community south of Khamissat, this paper represents the first assessment of Vision 2020’s performance thus far to combat the spread of type 2 diabetes among rural …

When The Books Hit Back: Perceived Stress In University Students, Henry Stoddard

Independent Study Project (ISP) Collection

University students are a particularly high-risk population for mental illness due to high-stress levels. The university students of KwaZulu Natal, South Africa are no exception to that trend. This study surveyed and interviewed university students, and interviewed various mental health professionals from the Durban region of South Africa. The data was analyzed and used to better understand the current status of South African university students’ perceived stress, as well as the causes of their stress levels. Results showed no significant differences among demographic groups and perceived stress levels, but further research is needed to draw more reliable conclusions. In the …

The Latex Journey: A Narrative Approach To Exploring Condom Use, Stigma, And Education From The Perspective Of Women In Masxha, Kylie Yocum

Independent Study Project (ISP) Collection

Although the South African National Department of Health (NDOH) is spending increasing amounts of money on improving their HIV programs (including the rollout of new, scented condoms for their condom distribution program), the rates of condom use at last sexual encounter are declining. This inquiry focused on young women in the neighborhood of Masxha, Cato Manor, and their opinions surrounding how condoms are being used or misused, as well as the gender norms that perpetrate this (mis)use. This inquiry demonstrated the narratives of these young women on factors such as condom acquisition, gendered stigma, and condom education, including the Life …

The Perceived Mental Health Effects Of China’S One-Child Policy, Avery Rasmussen

Independent Study Project (ISP) Collection

This study looked at the perceived impacts of China’s 30 year One-Child Policy (OCP). Previous studies suggested the OCP affected Chinese culture and society in a number of ways, however no studies (to the knowledge of the principal investigator) had looked at perceptions of the effects of the OCP on anxiety levels and other mental health issues of students in China. This study sought to fill the aforementioned knowledge gap and aimed to determine perceptions about the mental health effects of the OCP on students. Specifically, this study endeavored to gain a better understanding of perceptions of the effects of …

A Comparative Study Of The Barriers To Hiv Self-Management Among Myanmar Migrant And Han Chinese Women In Yunnan, China, Anna Gaden

Independent Study Project (ISP) Collection

HIV has transitioned from high-risk populations to the general population through sexual transmission – now the primary mode of transmission in China – and is currently the biggest public health crisis in China. Those who are not directly involved with commercial sex work (CSW) or intravenous drug use (IDU) are now vulnerable to contraction. Han Chinese women, especially young women, are generally more vulnerable to transmission than their male counterparts, both physically and socially, and the virus affects their lives more deeply. Myanmar migrant women are even more vulnerable, as their migrant status leaves them without support structures or protections …

Essential Newborn Care During Humanitarian Crises: Integration Of Low-Cost Interventions, Athena Wong

Independent Study Project (ISP) Collection

Newborn healthcare has long been neglected on the international agenda despite neonatal death making up 44% of all under-five deaths. Neonates are newborns under 28 days of age and are the most vulnerable population with the highest risk of mortality during humanitarian emergencies. The common misconception that neonatal healthcare is very expensive and requires delivery from highly skilled healthcare professionals must be dismissed. There are many low-cost interventions that are highly effective at saving lives, the most notable ones being kangaroo mother care, bag and mask resuscitation, and basic immunizations. The leading causes of neonatal death are prematurity, intrapartum complications, …

Managing Health In All The Helpers: A Survey Of Mental Health Services For Humanitarian Aid Workers, Erin Mercado

Independent Study Project (ISP) Collection

Humanitarianism has been a long-standing principle of helping those in need. However, the work of providing such assistance is not an easy feat. Humanitarian work is mentally taxing because of the high daily demands of the job as well as the potential for exposure to direct and secondary traumatization. These mental health risks can manifest into the mental health disorders if the stressors of the job are not well managed by individual aid workers and by the humanitarian organizations. The most common mental health disorders experienced by aid workers are depression, anxiety, burnout, and PTSD. Research into mental health and …

De Novo Descending Aorta Thrombus In A Patient With Metastatic Colorectal Cancer: A Case Report, Om Parkash, Adil Ayub, Buria Naeem, Saeed Hamid

Section of Gastroenterology

Thromboembolic events in patients with cancer are frequently reported in literature and usually involve the venous circulation. De novo thrombus formation in the arterial system without any underlying atherosclerosis, dissection or aneurysm is extremely rare. We report the case of a patient with metastatic colorectal carcinoma who developed a thrombus in the descending aorta without any intervention or risk factors. The patient presented with non-specific gastrointestinal symptoms. A CT scan revealed an aortic thrombus obstructing 70% of the lumen. She opted for no treatment of her thrombus and was later complicated by extensive lower limb emboli. Patients with aortic thrombosis …

Population Health Research: Early Description Of The Organizational Shift Toward Population Health Management And Defining A Vision For Leadership., Kristi L. Caldararo, David B. Nash

College of Population Health Faculty Papers

As health care delivery systems adapt to the changing marketplace, many struggle to define a clear strategy that will prove successful in managing the health of entire populations. The federal government continues to put increasing pressure on organizations to shift away from the traditional way of delivering episodic care and move toward managing populations as a whole-before, during, and after a patient presents in a health care facility. Private payers have begun to follow suit as risk-based payer contracts and bundled payment models become increasingly popular. For organizations to adequately influence the health outcomes of a population, they must be …

Detection And Molecular Status Of Isospora Sp. From The Domestic Pigeon (Columba Livia Domestica)., Ryuma Matsubara, Yasuhiro Fukuda, Fumi Murakoshi, Osamu Nomura, Toru Suzuki, Chika Tada, Yutaka Nakai

Department of Biochemistry and Molecular Biology Faculty Papers

The domestic pigeon, Columba livia domestica, is reared for meat production, as a pet, or for racing. Few reports have characterized the parasitic protists from the genus Isospora isolated from Columbiformes. We detected Isospora-like oocysts from C. livia reared for racing. The oocyst contained two sporocysts, and each sporocyst included four sporozoites. The sporulated oocysts (n=4) were spherical; their mean diameters were 25.6 (24.0-27.2)×24.7 (23.4-26.0) μm. Micropyles, polar granules, and oocyst residuum were absent. The mean length and width of the sporocysts (n=8) were 19.5 (18.5-20.5) and 11.2 (10.2-12.1) μm, respectively. Stieda and sub-Stieda bodies were observed. Single-oocyst PCR revealed …

Development Of Field-Applicable Tests For Rapid And Sensitive Detection Of Candidatus Phytoplasma Oryzae, Lillian Wambua, Bernd Schneider, Allan Okwaro, Joseph Odhiambo Wanga, Olive Imali, Peninah Nduku Wambua, Lavender Agutu, Cassandra Olds, Chris Stephen Jones, Daniel Masiga, Charles Midega, Zeyaur Khan, Joerg Jores, Anne Fischer

All Peer-Reviewed Publications

Napier grass Stunt Disease (NSD) is a severe disease of Napier grass (Pennisetum purpureum) in Eastern Africa, caused by the leafhopper-transmitted bacterium Candidatus Phytoplasma oryzae. The pathogen severely impairs the growth of Napier grass, the major fodder for dairy cattle in Eastern Africa. NSD is associated with biomass losses of up to 70% of infected plants. Diagnosis of NSD is done by nested PCR targeting the phytoplasma DNA, which is difficult to perform in developing countries with little infrastructure. We report the development of an easy to use, rapid, sensitive and specific molecular assay for field diagnosis of NSD. The …

Myocardial Infarction In The Wisconsin Longitudinal Study: The Interaction Among Environmental, Health, Social, Behavioural And Genetic Factors, Tina K. Gonzales, James A. Yonker, Vicky Chang, Carol L. Roan, Pamela Herd, Craig S. Atwood

Research outputs 2014 to 2021

Objectives:

This study examined how environmental, health, social, behavioural and genetic factors interact to contribute to myocardial infarction (MI) risk.

Design:

Survey data collected by Wisconsin Longitudinal Study (WLS), USA, from 1957 to 2011, including 235 environmental, health, social and behavioural factors, and 77 single- nucleotide polymorphisms were analysed for association with MI. To identify associations with MI we utilized recursive partitioning and random forest prior to logistic regression and chi-squared analyses.

Participants:

6198 WLS participants (2938 men; 3260 women) who (1) had a MI before 72 years and (2) had a MI between 65 and 72 years. …