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2017

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Articles 181 - 210 of 14527

Full-Text Articles in Medicine and Health Sciences

The Head Shake Sensory Organization Test (Hs-Sot): Normative Data And Correlation With Dynamic Visual Acuity Testing, Andrea E. Cripps, Scott C. Livingston Dec 2017

The Head Shake Sensory Organization Test (Hs-Sot): Normative Data And Correlation With Dynamic Visual Acuity Testing, Andrea E. Cripps, Scott C. Livingston

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

Background: Among healthy (asymptomatic) subjects and patients, the relationship between performance on the Head Shake Sensory Organization Test (HS-SOT) and performance on the Dynamic Visual Acuity (DVA) testing has not been reported. The purpose of this study was to establish normative data for the HS-SOT and compare performance on the HS-SOT and the DVA test. Hypothesis: A strong positive correlation would exist between the DVA and the HS-SOT. Study Design: A cross-sectional design was used. Level of Evidence: Level 3. Methods: Sixty asymptomatic subjects (34 females, 26 males, ages 20 to 26 years, 23.7±1.6) participated. Each subject’s dynamic balance …


Utilization Of Cupping Therapy In The Treatment Of Vascular Thoracic Outlet Syndrome In A Collegiate Pitcher: A Case Study, Stephen A. Cage, Diana M. Gallegos, Brandon J. Warner Dec 2017

Utilization Of Cupping Therapy In The Treatment Of Vascular Thoracic Outlet Syndrome In A Collegiate Pitcher: A Case Study, Stephen A. Cage, Diana M. Gallegos, Brandon J. Warner

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

Objective: Present a clinical case detailing the effectiveness of dry cupping therapy in treating thoracic outlet syndrome. The utilization of dry cupping therapy on a 20-year-old collegiate baseball pitcher with diagnosed thoracic outlet syndrome is presented. Background: Thoracic outlet syndrome is a relatively rare musculoskeletal condition affecting 1/100,000 patients annually. Dry cupping therapy is an ancient therapeutic modality that utilizes various means of suction with the goal of decompressing myofascial layers. Treatment: Following diagnosis, patient was successfully treated in two weeks using dry cupping therapy. The patient experienced no further incidence of thoracic outlet syndrome symptoms and was able …


Athletic Trainers’ Knowledge Of Legal Practice Within Information Technology And Social Media, Elizabeth R. Neil, Zachary K. Winkelmann, Lindsey E. Eberman Dec 2017

Athletic Trainers’ Knowledge Of Legal Practice Within Information Technology And Social Media, Elizabeth R. Neil, Zachary K. Winkelmann, Lindsey E. Eberman

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

Purpose: As healthcare and technology continue to connect in daily practice, athletic trainers (ATs) must be knowledgeable of the governing acts for ethical and legal clinical practice. This is vital to ensure ethical and legal practice as a clinician and protection of confidential protected health information (PHI). The objective of this study was to assess certified athletic trainers’ knowledge of regulations within technology and social media (SoMe). Methods: Certified ATs were recruited from the National Athletic Trainers’ Association membership database. Respondents completed an instrument of 28 questions, including 16 participant demographics, clinical site demographics, SoMe usage and general questions, and …


Iron Deficiency Anemia As A Risk Factor For Simple Febrile Seizures, Tipu Sultan, Abdul Islam Hanif Hanif, Shaila Ali Dec 2017

Iron Deficiency Anemia As A Risk Factor For Simple Febrile Seizures, Tipu Sultan, Abdul Islam Hanif Hanif, Shaila Ali

Pakistan Journal of Neurological Sciences (PJNS)

To determine the association of iron deficiency anemia with simple febrile seizures in children presenting in a tertiary care hospital.


A Silver Lining In The Dark Clouds: Medical Marijuana, In The Neurological Disorders And Its Future In Pakistan., Qamar Zaman, Maimoona Siddiqui Dec 2017

A Silver Lining In The Dark Clouds: Medical Marijuana, In The Neurological Disorders And Its Future In Pakistan., Qamar Zaman, Maimoona Siddiqui

Pakistan Journal of Neurological Sciences (PJNS)

Marijuana has been included in the list of illicit drugs for a long time despite its use as a remedy for several medical problems. However this use has been on the basis of the individual experiences with no concrete scientific evidence. Its positive effects have been mostly overshadowed by its recreational use worldwide. It has recently become the topic of hot debate due to several studies showing its role in various medical and especially neurological disorders. These new findings have created a controversy and world is still divided on its legalization for medicinal purpose. Several countries and states have legalized …


“These Classes Have Been My Happy Place”: Feasibility Study Of A Self-Care Program In Native Hawaiian Custodial Grandparents, Loriena Yancura, Heather Greenwood-Junkermeier, Christine A. Fruhauf Dec 2017

“These Classes Have Been My Happy Place”: Feasibility Study Of A Self-Care Program In Native Hawaiian Custodial Grandparents, Loriena Yancura, Heather Greenwood-Junkermeier, Christine A. Fruhauf

Asian/Pacific Island Nursing Journal

Native Hawaiian custodial grandparents have a distinctive set of strengths and challenges that may lead them to benefit from a structured self-care program. The purpose of this paper is to describe a feasibility study with nine Native Hawaiian custodial grandparents who participated in a 6-week self-care intervention. Based on open-ended questions during the post-questionnaire and at the 6-month follow-up focus group, grandparent participants noted that their grandchildren needed education and clothing. Most grandparents did not endorse statements that their grandchildren had any mental or physical health conditions. Grandparents reflected that the intervention provided them with skills to help cope with …


Metabolic Dysregulation And Cancer Mortality In A National Cohort Of Blacks And Whites, Tomi Akinyemiju, Justin Xavier Moore, Suzanne Judd, Susan Lakoski, Michael Goodman, Monika M. Safford, Maria Pisu Dec 2017

Metabolic Dysregulation And Cancer Mortality In A National Cohort Of Blacks And Whites, Tomi Akinyemiju, Justin Xavier Moore, Suzanne Judd, Susan Lakoski, Michael Goodman, Monika M. Safford, Maria Pisu

Epidemiology and Environmental Health Faculty Publications

Background: We examined the association between metabolic dysregulation and cancer mortality in a prospective cohort of Black and White adults.

Methods: A total of 25,038 Black and White adults were included in the analysis. Metabolic dysregulation was defined in two ways: 1) using the joint harmonized criteria for metabolic syndrome (MetS) and 2) based on factor analysis of 15 variables characterizing metabolic dysregulation. We estimated hazards ratios (HRs) and 95% confidence intervals (CIs) for the association of MetS and metabolic dysregulation with cancer mortality during follow-up using Cox proportional hazards models.

Results: About 46% of Black and 39% of White …


Letter From The Editor, Amanda Evert Dec 2017

Letter From The Editor, Amanda Evert

Administrative Issues Journal

The Winter 2017 issue of the AIJ begins with an invited article on the evolution of a bridge-to-college program at Idaho State University.


The Intersection Of Anger Management Counseling And Embodiment In Dance/Movement Therapy, Maria Parise Dec 2017

The Intersection Of Anger Management Counseling And Embodiment In Dance/Movement Therapy, Maria Parise

Creative Arts Therapies Theses

The purpose of this research study was to explore how the embodiment of aspects of anger may integrate within anger management counseling. Through this research, the first step was taken in exploring the physical expression of anger as an intervention tool in anger management counseling. A personal understanding of anger expression and management was established which may be utilized in future dance/movement therapy (DMT) sessions. This study was guided by multiple research questions: How might the embodiment of anger integrate with anger management counseling? How might the sensations, images, feelings, and thoughts experienced in anger management sessions lead to an …


A Heuristic Inquiry Into The Subjective Lived Experience And Expression Of Authenticity As A Developing Dance/Movement Therapist, Elyssa M. Yeh Dec 2017

A Heuristic Inquiry Into The Subjective Lived Experience And Expression Of Authenticity As A Developing Dance/Movement Therapist, Elyssa M. Yeh

Creative Arts Therapies Theses

The purpose of this self-study was to explore and understand my subjective lived experience and expression of the phenomenon of authenticity, which included identifying the components of my professional identity; discerning the challenges, barriers, and limitations to my full experience and expression of authenticity; establishing awareness of when I am and when I am not engaging fully with my authenticity; and developing a sense of authenticity within myself that is adaptable to a variety of situations and relationships. Moustakas (1990) six-steps of a heuristic investigation were implemented in this qualitative inquiry. Data was collected using art-making methods and analyzed using …


9-Aminoacridine Inhibits Ribosome Biogenesis And Synergizes With Cytotoxic Drugs To Induce Selective Killing Of P53-Deficient Cells, Leonid Anikin, Dimitri G Pestov Dec 2017

9-Aminoacridine Inhibits Ribosome Biogenesis And Synergizes With Cytotoxic Drugs To Induce Selective Killing Of P53-Deficient Cells, Leonid Anikin, Dimitri G Pestov

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Common cancer treatments target rapidly dividing cells and do not discriminate between cancer and normal host cells. One approach to mitigating negative side‐effects of cancer treatment is to temporarily arrest cell cycle progression and thus protect normal cells during cytotoxic treatments, a concept called cyclotherapy. We recently proposed that transient inhibition of post‐transcriptional steps of ribosome biogenesis (RBG) can be used to selectively arrest p53‐positive host cells and not p53‐null cancer cells. In this study, we investigated whether cytoprotective RBG inhibition can be achieved through small molecule treatment.


Modification Of The Ribosome As Part Of The Adaptive Response To Oxidative Stress In Yeast, Jessica A Zinskie, Daniel Shedlovskiy, Ethan Gardner, Dimitri G Pestov, Natalia Shcherbik Dec 2017

Modification Of The Ribosome As Part Of The Adaptive Response To Oxidative Stress In Yeast, Jessica A Zinskie, Daniel Shedlovskiy, Ethan Gardner, Dimitri G Pestov, Natalia Shcherbik

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Living organisms are constantly exposed to a variety of environmental and internal stressors tha tare detrimental to their cellular physiology and viability. One such condition, oxidativestress, is caused by abnormal amounts of Reactive Oxygen Species (ROS) that can lead to damage to proteins, nucleic acids, and lipids. Although the mechanisms to neutralize ROS have been widely studied, the understanding of ROS‐mediated signaling for these mechanisms is rather incomplete and sparse. We have uncovered a previously undescribed phenomenon of yeast ribosomes to respond to elevated levels of ROS through a specific endonucleolytic cleavage of the 25S rRNA in the c‐loop of …


Invited Article: Bridging The Gap – Supporting The Transition From High School To College, Julie A. Frischmann, Kelly S. Moor Dec 2017

Invited Article: Bridging The Gap – Supporting The Transition From High School To College, Julie A. Frischmann, Kelly S. Moor

Administrative Issues Journal

Idaho State University’s Bengal Bridge is a summer program designed to help students successfully transition from high school to their first year of college at Idaho State University. All Bridge students at ISU take two general education courses, plus an additional credit of supplemental instruction focused on academic strategies specific to the disciplines represented by those general education courses, as well as a First Year Transition (ACAD) course to facilitate engagement with and acculturation to the university community—a total of nine to 10 credits in just seven weeks. Bridge students are also supported by one-to-one academic coaching, supplemental tutoring, peer …


Classical Literature Gives Life To Business Paradox And Systems Integration, Robert A. Page, Samuel K. Andoh, Robert A. Smith Dec 2017

Classical Literature Gives Life To Business Paradox And Systems Integration, Robert A. Page, Samuel K. Andoh, Robert A. Smith

Administrative Issues Journal

Professors bemoan the great difficulty students have understanding the complexity of their disciplines or functional specializations. Many non-traditional students have work and family commitments that limit the time needed to reflect professionally and to master these concepts. This disconnect has persisted despite decades of work developing more integrated, interdisciplinary curricula. One potential, partial solution is to simply start sooner and partner with liberal arts courses to introduce business students to complexity and paradox before they arrive at the business school. Grounding these concepts in the Classics embeds them in great stories of passion, betrayal, commitment, and emotion normally absent in …


Addressing Uncertainty During Workplace Change: Communication And Sense-Making, Rich Parsells Dec 2017

Addressing Uncertainty During Workplace Change: Communication And Sense-Making, Rich Parsells

Administrative Issues Journal

Change is a commonplace occurrence in today’s organizations. A number of scholars suggest that communication strategies during organizational change are an important element to the success of a change initiative, yet such strategies are not given primacy in the research literature. The purpose of this paper is to add to the discourse on communication and workplace change initiatives by reporting on a research project that explored communication actions which were employed and viewed as useful by those experiencing a change in the workplace. This paper presents the findings that emanated from the study and explore their meaning in relation to …


How Managers Use The Stockdale Paradox To Balance “The Now And The Next”, C. W. Von Bergen, Martin S. Bressler Dec 2017

How Managers Use The Stockdale Paradox To Balance “The Now And The Next”, C. W. Von Bergen, Martin S. Bressler

Administrative Issues Journal

Recent discussions of leadership paradoxes have suggested that managers who can hold seemingly opposed, yet interrelated perspectives, are more adaptive and effective. One such paradox that has received relatively little attention is the “Stockdale Paradox,” named after Admiral James Stockdale, an American naval officer who was held captive for seven and one-half years during the Vietnam War and survived imprisonment in large part because he held beliefs of optimism about the future, while simultaneously acknowledging the current reality of the desperate situation in which he found himself. This contradictory tension enabled him and his followers to emerge from their situation …


Understanding Huntington's Disease Using Machine Learning Approaches, Sonali Lokhande Dec 2017

Understanding Huntington's Disease Using Machine Learning Approaches, Sonali Lokhande

KGI Theses and Dissertations

Huntington’s disease (HD) is a debilitating neurodegenerative disorder with a complex pathophysiology. Despite extensive studies to study the disease, the sequence of events through which mutant Huntingtin (mHtt) protein executes its action still remains elusive. The phenotype of HD is an outcome of numerous processes initiated by the mHtt protein along with other proteins that act as either suppressors or enhancers of the effects of mHtt protein and PolyQ aggregates. Utilizing an integrative systems biology approach, I construct and analyze a Huntington’s disease integrome using human orthologs of protein interactors of wild type and mHtt protein. Analysis of this integrome …


When It Just Won't Go Away: Oral Artemisinin Monotherapy In Nigeria, Threatening Lives, Threatening Progress., Kathryn A. O'Connell, Vamsi Vasireddy, Megan Littrell, Andria Rusk, Actwatch Group, Chinazo Ujuju, Jennifer Anyanti, Paul N Newton, Godwin Ntadom Dec 2017

When It Just Won't Go Away: Oral Artemisinin Monotherapy In Nigeria, Threatening Lives, Threatening Progress., Kathryn A. O'Connell, Vamsi Vasireddy, Megan Littrell, Andria Rusk, Actwatch Group, Chinazo Ujuju, Jennifer Anyanti, Paul N Newton, Godwin Ntadom

Collected Faculty Scholarship

BACKGROUND: Oral artemisinin monotherapy (AMT), an important contributor to multi-drug resistant malaria, has been banned in Nigeria. While oral AMT has scarcely been found for several years now in other malaria-endemic countries, availability has persisted in Nigeria's private sector. In 2015, the ACTwatch project conducted a nationally representative outlet survey. Results from the outlet survey show the extent to which oral AMT prevails in Nigeria's anti-malarial market, and provide key product information to guide strategies for removal.

RESULTS: Between August 10th and October 3rd, 2015 a total of 13,480 outlets were screened for availability of anti-malarials and/or malaria blood testing …


In Memoriam 2017, Stephen J. Langendorfer Ph.D. Dec 2017

In Memoriam 2017, Stephen J. Langendorfer Ph.D.

International Journal of Aquatic Research and Education

In Memoriam 2017 - Adolph Kiefer, Louise Priest, Terry Laughlin


Improving Obesity Management In Primary Care, Jeffrey M. Waddell Dec 2017

Improving Obesity Management In Primary Care, Jeffrey M. Waddell

Doctor of Nursing Practice Scholarly Project

This project examined how advanced practice nurses (APNs) manage overweight and obesity in primary care. Not only were their general attitudes and beliefs toward overweight and obesity explored, but their beliefs about the treatment and management of obesity were also examined. The APNs’ knowledge and current practice with managing obesity in the primary care setting were evaluated. This project went on to examine the APNs’ awareness and utilization of clinical practice guidelines in managing overweight and obesity. Finally, the study asked about the perceived impact of a website designed to provide guidance managing obesity based on the American Association of …


Targeting Ribosome Assembly Factors Selectively Protects P53 Positive Cells From Chemotherapeutic Agents, Russell T. Sapio, Anastasiya Nezdyur, Matthew Krevetski, Leonid Anikin, Vincent J. Manna, N. Minkovsky, Dimitri G Pestov Dec 2017

Targeting Ribosome Assembly Factors Selectively Protects P53 Positive Cells From Chemotherapeutic Agents, Russell T. Sapio, Anastasiya Nezdyur, Matthew Krevetski, Leonid Anikin, Vincent J. Manna, N. Minkovsky, Dimitri G Pestov

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Many chemotherapeutic agents act in a nondiscriminatory fashion, targeting both cancerous and noncancerous cells in Sphase and Mphase. One approach to reduce the toxic side effects in normal tissue is to exploit the differences in p53 functionality between cancerous and noncancerous cells. For example, activating p53 signaling by nongenotoxic means can transiently arrest noncancerous p53 positive cells in G1 phase and protect them from the cytotoxic effects of chemotherapeutic drugs. However, since most cancerous cells have faulty p53 signaling, they will proceed to cycle, and continue to be affected by the drug. In this study we asked if this G1‐phase …


Improving Nursing Adherence To Pediatric Pain Management Bundle Using The Pdsa Cycle, Stephen W. Lovern Dec 2017

Improving Nursing Adherence To Pediatric Pain Management Bundle Using The Pdsa Cycle, Stephen W. Lovern

Doctor of Nursing Practice (DNP) Final Clinical Projects, 2016-2019

Given the current standards, pediatric post-operative pain management can be a distressing outcome to the patient and family. Adequate management of post-op pain in this population is a challenge despite the availability of evidence-based interventions combined to form care bundles. Tonsillectomies are common procedures in the pediatric population and often include moderate to severe pain with ineffective pain relief. Inadequate pain management leads to unplanned admissions, longer post anesthesia care unit (PACU) stays, slower oral intake, and longer recovery periods. In this project, two interventions were tested using the plan-do-study-act (PDSA) model for rapid cycle improvements. The first intervention was …


Quality Improvement In Provider Attitudes Towards Adherence To Comprehensive Diabetic Care Hedis Standards, Samantha Taylor Dec 2017

Quality Improvement In Provider Attitudes Towards Adherence To Comprehensive Diabetic Care Hedis Standards, Samantha Taylor

Doctor of Nursing Practice (DNP) Final Clinical Projects, 2016-2019

Healthcare Effectiveness Data and Information Set (HEDIS) is a quality measurement for standard of care used to rate a health plan or provider's ability to demonstrate clinical effectiveness. Medicare Advantage healthcare plan utilizes HEDIS as a guide for standard of care. Adherence to HEDIS is useful in decreasing chronic disease burden through preventative measures. Diabetes, a disease with high burden, has Comprehensive Diabetes Care HEDIS standards that specifically target providers. Increasing adherence to HEDIS measures is shown to significantly improve health outcomes when used with evidence-based guidelines. The literature shows having high HEDIS scores are not an incentive to adhere …


The Effectiveness Of Education And Cognitive Rehearsal In Managing Nurse-To-Nurse Incivility, Deborah B. Kile Dec 2017

The Effectiveness Of Education And Cognitive Rehearsal In Managing Nurse-To-Nurse Incivility, Deborah B. Kile

Doctor of Nursing Practice (DNP) Final Clinical Projects, 2016-2019

This project was designed to evaluate the effectiveness of education on nurse-to-nurse incivility and use of cognitive rehearsal techniques on registered nurses' perception of their ability to recognize and confront incivility, along with resulting job satisfaction. Nurse-to-nurse incivility negatively affects nurses, organizations and patients. The Tri-Council for Nursing's proclamation calls nurses to recognize incivility and take steps to eliminate this in practice ("Tri-Council" 2017). A mixed method, quality improvement pilot study was conducted. Participants, (registered nurses employed in a Post-Anesthesia Care Unit in a community hospital in Virginia), received education on incivility and cognitive rehearsal techniques. Data was collected through …


Identifying Ways That Institutional Staffing And Scheduling Committees Engage Nursing Staff In Resource Allocation At The Unit And Institutional Levels, Kevin M. Shimp Dec 2017

Identifying Ways That Institutional Staffing And Scheduling Committees Engage Nursing Staff In Resource Allocation At The Unit And Institutional Levels, Kevin M. Shimp

Doctor of Nursing Practice (DNP) Final Clinical Projects, 2016-2019

The American Nurses Association (ANA) recommends that at least fifty percent direct care providers are involved in staffing and scheduling decisions at the institutional level (ANA Staffing, 2015). This recommendation coincides with Magnet recommendations for the staff most impacted by staffing levels. Magnet organizations are recognized for superior nursing processes and quality patient care, which lead to the highest levels of safety, quality, and patient satisfaction (ANCC, 2015). Existing research, largely at the unit level, shows that registered nurses in acute care environments have higher general work satisfaction and morale when they are engaged in decision making around staffing (Ellerbe …


Pilot Of A Randomized Trial Comparing Outcomes Of Three Types Of Peripheral Intravenous Catheters (Pivc): Utilizing The Plan, Do, Study, Act Cycle, Heather Galang Dec 2017

Pilot Of A Randomized Trial Comparing Outcomes Of Three Types Of Peripheral Intravenous Catheters (Pivc): Utilizing The Plan, Do, Study, Act Cycle, Heather Galang

Doctor of Nursing Practice (DNP) Final Clinical Projects, 2016-2019

Peripheral intravenous catheters (PIVC) are used in high volume in acute and ambulatory settings. Due to high volume of use in patient care, complications from a PIVC can significantly impact patient experience. Literature indicates complications such as blood exposure, phlebitis, unplanned removal, infiltration, occlusion, dwell time, pain, and cost have serious consequences in patient care, leading to potential delays in treatment, patient discomfort, patient dissatisfaction, safety concerns, nursing interruptions, increased length of stay, and added costs. Gap analysis indicates additional research can prove beneficial for evidence-based care improvement. The authors propose using the plan, do, study, act to conduct a …


Improve Readmissions And Patient Satisfaction Scores With A Revised Discharge Education Plan, Michele M. Hughes Dec 2017

Improve Readmissions And Patient Satisfaction Scores With A Revised Discharge Education Plan, Michele M. Hughes

Doctor of Nursing Practice (DNP) Final Clinical Projects, 2016-2019

Problem: Payers of health insurance are tracking key performance measures and are limiting payments to hospitals. With this threat to financial reimbursement hospital systems have increased emphasis on tracking and improving outcomes. The purpose of this project is to reduce all-cause 30-day readmissions and improve patient satisfaction scores in the care transitions domain after a total hip or total knee replacement by revising the discharge materials and education.

Method: The total joint replacement discharge education materials were revised to address the common causes of readmissions. The documents were reformatted to improve literacy level, readability, and patient learning. Nurses were educated …


New Nurse Huddle Pilot To Improve New Graduate Nurse Retention, Timothy Craddock Dec 2017

New Nurse Huddle Pilot To Improve New Graduate Nurse Retention, Timothy Craddock

Doctor of Nursing Practice (DNP) Final Clinical Projects, 2016-2019

Purpose: With the continued nursing shortage, it has become increasingly important for healthcare organizations to focus on nurse retention to maintain quality of care standards and maintain fiscal responsibility. The purpose of this project was to pilot a new graduate nurse huddle to improve retention of new graduate nurses.

Method: A new graduate nurse huddle was developed using past nurse residency cohort Casey-Fink Graduate Nurse Experience Survey data to focus on areas of poor performance. Mixed methods surveys were administered pre-huddle and post-huddle to measure participant intent to stay and perception of huddle value. Descriptive statistics were used to evaluate …


Improving Adherence To Mental Health Treatment In A Low-Income Clinic, Janice G. Gandy Dec 2017

Improving Adherence To Mental Health Treatment In A Low-Income Clinic, Janice G. Gandy

Doctor of Nursing Practice (DNP) Final Clinical Projects, 2016-2019

The increasing prevalence of mental illness in the United States presents significant challenges for primary care providers in low-income settings. Integrated Behavioral Health (IBH) programs have resulted in improved general health for low-income participants; however, managing appointment adherence, in which the patient attends appointment as scheduled, is particularly challenging. The purpose of this pilot project was to implement bundled interventions at a low-income primary care clinic to improve patient adherence to behavioral health treatment. The bundle of interventions included: 1) educational interventions emphasizing the benefits of IBH care 2) warm patient handoffs between the primary care provider to a behavioral …


The Role Of Mapk And Scf In The Destruction Of Med13 In Cyclin C Mediated Cell Death, David C Stieg, Stephen D Willis, Joseph Scuorzo, Mia Song, Vidyaramanan Ganesan, Randy Strich, Katrina F Cooper Dec 2017

The Role Of Mapk And Scf In The Destruction Of Med13 In Cyclin C Mediated Cell Death, David C Stieg, Stephen D Willis, Joseph Scuorzo, Mia Song, Vidyaramanan Ganesan, Randy Strich, Katrina F Cooper

Rowan-Virtua School of Osteopathic Medicine Departmental Research

In response to stress, the yeast1 and mammalian2 cyclin C translocate from the nucleus to the cytoplasm, where it associates with the GTPase Drp1/Dnm1 to drive mitochondrial fragmentation and apoptosis. Therefore, the decision to release cyclin C represents a key life or death decision. In unstressed cells, the cyclin C‐Cdk8 kinase regulates transcription by associating with the Mediator of RNA polymerase II. We previously reported that the Mediator component Med13 anchors cyclin C in the nucleus3. Loss of Med13 function leads to constitutive cytoplasmic localization of cyclin C, resulting in fragmented mitochondria, hypersensitivity to stress and …