Medicine and Health Sciences Commons^™

Epigenetic Impact Of Endocrine Disrupting Chemicals On Lipid Homeostasis And Atherosclerosis: A Pregnane X Receptor-Centric View, Robert N. Helsley, Changcheng Zhou

Pharmacology and Nutritional Sciences Faculty Publications

Despite the major advances in developing diagnostic techniques and effective treatments, atherosclerotic cardiovascular disease (CVD) is still the leading cause of mortality and morbidity worldwide. While considerable progress has been achieved to identify gene variations and environmental factors that contribute to CVD, much less is known about the role of “gene–environment interactions” in predisposing individuals to CVD. Our chemical environment has significantly changed in the last few decades, and there are more than 100,000 synthetic chemicals in the market. Recent large-scale human population studies have associated exposure to certain chemicals including many endocrine disrupting chemicals (EDCs) with increased CVD risk, …

Functional Neuroplasticity In The Nucleus Tractus Solitarius And Increased Risk Of Sudden Death In Mice With Acquired Temporal Lobe Epilepsy, Isabel D. Derera, Brian P. Delisle, Bret N. Smith

Physiology Faculty Publications

Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in individuals with refractory acquired epilepsy. Cardiorespiratory failure is the most likely cause in most cases, and central autonomic dysfunction has been implicated as a contributing factor to SUDEP. Neurons of the nucleus tractus solitarius (NTS) in the brainstem vagal complex receive and integrate vagally mediated information regarding cardiorespiratory and other autonomic functions, and GABAergic inhibitory NTS neurons play an essential role in modulating autonomic output. We assessed the activity of GABAergic NTS neurons as a function of epilepsy development in the pilocarpine-induced status epilepticus (SE) model of …

Metastatic Deaths In Retinoblastoma Patients Treated With Intraarterial Chemotherapy (Ophthalmic Artery Chemosurgery) Worldwide., David H. Abramson, Carol L. Shields, Pascal Jabbour, Luiz Fernando Teixeira, José Roberto Falco Fonseca, Marcio Chaves Pedro Marques, Francis L. Munier, Francesco Puccinelli, Theodora Hadjistilianou, Sandra Bracco, Guillermo Chantada, Alejandro Ceciliano, Y. Pierre Gobin

Department of Neurosurgery Faculty Papers

BACKGROUND: Ophthalmic artery chemosurgery [OAC, intra-arterial chemotherapy (IAC)] was introduced in 2006 as treatment modality for intraocular retinoblastoma. The purpose of this commentary is to retrospectively review the incidence of metastatic deaths in retinoblastoma patients treated with OAC worldwide over a 10 year period. Retrospective data regarding metastatic deaths was collected from six international retinoblastoma centers (New York City USA, Philadelphia USA, Sao Paulo Brazil, Siena Italy, Lausanne Switzerland and Buenos Aires Argentina). All retinoblastoma patients from these centers (naive and recurrent, unilateral and bilateral) treated with OAC/IAC since 2006 have been included in this study. Data regarding number of …

Week Of October 23, 2017, New York Medical College

InTouch

• SHSP Hosts Special Dean's Lecture
• NYMC Ranks High in Low Student Loan Default Rates
• Department of Microbiology and Immunology Receives Generous Gift
• 19th Annual Race for Rehab Supports Achilles International
• Students Clubs Enrich Campus Life
• NYMC Has Heart
• D.P.T. Class of 2019 Celebrates National Physical Therapy Month

A Mixed-Method Multiple Case Study Of Three Business Models For Local Healthy Food Delivery Systems In Underprivileged Urban Areas, Gretchen Elizabeth Krivak, Garth B. Woodruff, S. Forrest, Hannah Mbungu, Kechler Orcel, Soraya Fish, Sherine R. Brown-Fraser

Faculty Publications

Define a USDA food desert Analyze the three business models for benefits and deficiencies Identify methods for starting a sustainable mobile farmers market program. Over 40% of Berrien County Michigan land use is agricultural. Many products are fruits and vegetables. Yet, the county has six identified USDA defined Food Deserts. Past research, based on a mobile farmers market, confirmed local trends and deficits. The purpose for this research is to define a sustainable business model that delivers healthy local food options to USDA Food Deserts combating food inequity. A mixed method multiple case study was created to test three business …

Medical School Watercooler Newsletter - October 22, 2017, Lindsey Lyle

Watercooler Newsletter

This is the October 22, 2017 edition of the Frederick P. Whiddon College of Medicine's Newsletter - Watercooler.

Contents Include:

Dr. Christopher Anderson to Present Frazer/Leigh Memorial Lecture

Med School Café- Expert Advice For the Community

Mark Your Calendar: Upcoming Town Hall Meeting

Dr. Richard Honkanen Collaborates with Leading Researchers Across the Globe in Search of Treatment for Rare Disease

USA Welcomes Dr. Jin H. Kim

This Week: Rainbow Cancer Walk-A-Thon

Advocacy In The Workplace: Raising Awareness About Huntington's Disease And Brain Health, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Teaching Students To Be Spiritually Sensitive: Learning From A Spirituality Course Evaluation, Ann M. Callahan, Kalea Benner

EKU Faculty and Staff Scholarship

Rationale

The way educators address spirituality can create a sense of community or social isolation. This necessitates a spiritually sensitive approach that enables students to build spiritual competence. Spiritual competence reflects an understanding of how spirituality shapes human behavior, how spiritual diversity manifests and can lead to risk for discrimination, and how to communicate spiritual sensitivity in professional relationships (NASW, 2008, 2007). Research shows that educators have helped students explore themselves and others spiritually (Barker & Floersch, 2010; Johnston, Mamier, Bahjri, Anton, & Petersen; 2008), but more research is needed on how self-reflection informs spiritual competence (Hodge & Derezotes, 2008). …

Direct Effects Of The Home, School, And Consumer Food Environments On The Association Between Food Purchasing Patterns And Dietary Intake Among Rural Adolescents In Kentucky And North Carolina, 2017, Alison Gustafson, Stephanie Jilcott Pitts, Jordan Mcdonald, Hannah Ford, Paige Connelly, Rachel Gillespie, Emily Liu, Heather M. Bush, Candace Brancato, Toyin Babatande, Janet Mullins

Dietetics and Human Nutrition Faculty Publications

Background: Obesity rates are higher among rural versus urban adolescents. To examine possible mechanisms for the rural-urban adolescent obesity disparity, we examined the direct and indirect effects of food purchasing patterns, and the home, school, and consumer food environments on dietary intake among rural adolescents. Methods: A baseline survey was conducted among adolescents in eight rural high schools (four in Eastern Kentucky, and four in Eastern North Carolina). Participants answered questions about food purchasing patterns, dietary intake, home food availability, and demographics. The school and consumer food environments were assessed using validated measures from the School Meals Cost Study (United …

Pediatric Residency Training And Behavioral Health: Models And Outcomes, Jeffrey D. Shahidullah Phd, Paul W. Kettlewell Phd, Mohammed Palejwala Ma, Kathryn A. Dehart Md, Kris Rooney Md, Laura Diaz Md, Joanna Carlson Md

Department of Pediatrics

No abstract provided.

The Handoff Culture: Can We Change How An Icu To Floor Transfer Works?, Kristin Lohr, Md, Grant Turner, Md, Allison Greco, Md

House Staff Quality Improvement and Patient Safety Conference (2016-2019)

Handoffs between providers have increased following the implementation of the 2011 Accreditation Council for Graduate Medical Education (ACGME) work hour restrictions. Properly structured and timed handoffs are essential to patient safety.1 Despite this, studies have shown that errors in code status, medication allergies, and important updates to the problem list are common, all of which can lead to adverse outcomes to patients.2

At Thomas Jefferson University Hospital (TJUH) the 2016 Safety Culture Survey revealed that across all specialties, 37% of residents felt that things “fall through the cracks” when transferring patients from one unit to another.

Our interdepartmental Housestaff Quality …

Alcohol Consumption Impairs The Ependymal Cilia Motility In The Brain Ventricles, Alzahra J. Al Omran, Hannah C. Saternos, Yusuf S. Althobaiti, Alexander Wisner, Youssef Sari, Surya M. Nauli, Wissam A. Aboualaiwi

Pharmacy Faculty Articles and Research

Ependymal cilia protrude into the central canal of the brain ventricles and spinal cord to circulate the cerebral spinal fluid (CSF). Ependymal cilia dysfunction can hinder the movement of CSF leading to an abnormal accumulation of CSF within the brain known as hydrocephalus. Although the etiology of hydrocephalus was studied before, the effects of ethanol ingestion on ependymal cilia function have not been investigated in vivo. Here, we report three distinct types of ependymal cilia, type-I, type-II and type-III classified based upon their beating frequency, their beating angle, and their distinct localization within the mouse brain-lateral ventricle. Our studies …

Intravesical Rad-Ifnα/Syn3 For Patients With High-Grade, Bacillus Calmette-Guerin-Refractory Or Relapsed Non-Muscle-Invasive Bladder Cancer: A Phase Ii Randomized Study., Neal D Shore, Stephen A Boorjian, Daniel J Canter, Kenneth Ogan, Lawrence I Karsh, Tracy M Downs, Leonard G Gomella, Ashish M Kamat, Yair Lotan, Robert S Svatek, Trinity J Bivalacqua, Robert L Grubb, Tracey L Krupski, Seth P Lerner, Michael E Woods, Brant A Inman, Matthew I Milowsky, Alan Boyd, F Peter Treasure, Gillian Gregory, David G Sawutz, Seppo Yla-Herttuala, Nigel R Parker, Colin P N Dinney

Department of Medicine Faculty Papers

Purpose Many patients with high-risk non-muscle-invasive bladder cancer (NMIBC) are either refractory to bacillus Calmette-Guerin (BCG) treatment or may experience disease relapse. We assessed the efficacy and safety of recombinant adenovirus interferon alfa with Syn3 (rAd-IFNα/Syn3), a replication-deficient recombinant adenovirus gene transfer vector, for patients with high-grade (HG) BCG-refractory or relapsed NMIBC. Methods In this open-label, multicenter (n = 13), parallel-arm, phase II study ( ClinicalTrials.gov identifier: NCT01687244), 43 patients with HG BCG-refractory or relapsed NMIBC received intravesical rAd-IFNα/Syn3 (randomly assigned 1:1 to 1 × 10(11) viral particles (vp)/mL or 3 × 10(11) vp/mL). Patients who responded at months 3, …

Impacting Women's And Children's Health Care Globally- A United State-Haiti Nursing Partnership., Melissa Motz, Mary Aungst, Karen Groves

Patient Care Services / Nursing

No abstract provided.

Tnf-Α Promotes Nuclear Enrichment Of The Transcription Factor Tonebp/Nfat5 To Selectively Control Inflammatory But Not Osmoregulatory Responses In Nucleus Pulposus Cells., Zariel I. Johnson, Alexandra C. Doolittle, Joseph W. Snuggs, Irving M. Shapiro, Christine L. Le Maitre, Makarand V. Risbud

Department of Orthopaedic Surgery Faculty Papers

Intervertebral disc degeneration (IDD) causes chronic back pain and is linked to production of proinflammatory molecules by nucleus pulposus (NP) and other disc cells. Activation of tonicity-responsive enhancer-binding protein (TonEBP)/NFAT5 by non-osmotic stimuli, including proinflammatory molecules, occurs in cells involved in immune response. However, whether inflammatory stimuli activate TonEBP in NP cells and whether TonEBP controls inflammation during IDD is unknown. We show that TNF-α, but not IL-1β or LPS, promoted nuclear enrichment of TonEBP protein. However, TNF-α-mediated activation of TonEBP did not cause induction of osmoregulatory genes. RNA sequencing showed that 8.5% of TNF-α transcriptional responses were TonEBP-dependent and …

Duodenal Varices: A Rare Cause Of Gastrointestinal Bleeding., Anam Malik Md, Abdul Aleem Md, Eric Nellis Md, Hiral N. Shah Md

Department of Medicine

No abstract provided.

“I Feel Like I’M Drawing Strength From It”: Lived Experiences Of Filipino Elderly Participating In Craft-Making, Sharon B. Cajayon, Romeo Luis A. Macabasag, Norilyn Limchanco, Vanessa O. Umali, Ellayza N. Blas, Michelle S. Angulo, Cristine Joy A. Breguera, Nikka Angela A. De Guzman, Sheila N. Malapi, Emmalyn E. Quibote

The Qualitative Report

In this phenomenological study, we offer an insightful understanding of the lived experiences of seven (7) Filipino elderly participating in craft-making. We purposively selected the key informants from a municipality in the province of Bulacan, Philippines. The transcribed data gathered through a semi-structured in-depth interview was analyzed using Colaizzi’s approach. Six themes describing the lived experiences emerged: “Fostering friendship,” “Flourishing health,” “Furthering service,” “Facing aging with acceptance,” “Finding felicity and self-fulfillment,” “Feelings of belongingness and security.” Just like the sun, the elderly’s participation in craft-making serves as a nourishment for them. This exploration speaks to understanding the potential of craft-making …

Characterization Of Pulmonary Metastases In Children With Hepatoblastoma Treated On Children's Oncology Group Protocol Ahep0731 (The Treatment Of Children With All Stages Of Hepatoblastoma): A Report From The Children's Oncology Group., Allison F. O'Neill, Alexander J. Towbin, Mark D. Krailo, Caihong Xia, Yun Gao, M. Beth Mccarville, Rebecka L. Meyers, Eugene D. Mcgahren, Greg M. Tiao, Stephen P. Dunn, Max R. Langham, Christopher B. Weldon, Milton J. Finegold, Sarangarajan Ranganathan, Wayne L. Furman, Marcio Malogolowkin, Carlos Rodriguez-Galindo, Howard M. Katzenstein

Department of Pediatrics Faculty Papers

Purpose To determine whether the pattern of lung nodules in children with metastatic hepatoblastoma (HB) correlates with outcome. Methods Thirty-two patients with metastatic HB were enrolled on Children's Oncology Group Protocol AHEP0731 and treated with vincristine and irinotecan (VI). Responders to VI received two additional cycles of VI intermixed with six cycles of cisplatin/fluorouracil/vincristine/doxorubicin (C5VD), and nonresponders received six cycles of C5VD alone. Patients were imaged after every two cycles and at the conclusion of therapy. All computed tomography scans and pathology reports were centrally reviewed, and information was collected regarding lung nodule number, size, laterality, timing of resolution, and …

Jefferson Conference Sponsorship

Office of Diversity & Inclusion Initiatives Newsletter

Featuring:

• National Medical Association
• Gay and Lesbian Medical Association

Graduate Medical Education

Office of Diversity & Inclusion Initiatives Newsletter

To expand and enhance diversity and inclusion for our resident physicians, three initiatives targeting GME have been implemented.

Faculty Initiatives

Office of Diversity & Inclusion Initiatives Newsletter

New URM faculty welcome meeting

SKMC is committed to the career development of all faculty at Jefferson but recognize that those from a racial or ethnic group that is underrepresented in medicine, a woman in a specialty in which women are underrepresented and/or those who self-identify as lesbian, bisexual, gay, transgender, or questioning sexual identity may have unique concerns such as reducing isolation or finding a mentor with a similar background. Dr. Karen Novielli, Vice Dean for Faculty Affairs and Professional Development, along with Dr. Bernie Lopez, Associate Dean for Diversity and Community Engagement, meet individually with new faculty from …

Pipeline Programs

Office of Diversity & Inclusion Initiatives Newsletter

Pipeline programs are designed to prepare and inspire students to pursue careers in medicine and medical research. SKMC is committed to providing experiences and education to middle school, high school, college, and graduate students from groups underrepresented in the health care fields to increase the pool of qualified candidates applying to careers related to medicine and medical research.

Our programs:

• The Jefferson STEP-UP Medicine Program
• Future Health Professions Program (FHPP)

Diversity And Inclusion Education

Office of Diversity & Inclusion Initiatives Newsletter

In the 2016-2017 academic year, two then-second year SKMC students. Linda Magana and Kevin Guttierez, created and conducted a “Race and Medicine” course that first year SKMC students could receive credits for their Humanities Course. The Office of the Dean at SKMC has created a new lecture series called, “Confronting Racism, Bias, and Social Injustice in Healthcare.” This first-of-akind at Jefferson educational series is meant to educate on this important topic and to allow us to begin the discussions needed to move us forward in our quest to provide the best patient care. The content was developed by Drs. John …

Skmc Council On Diversity And Inclusion

Office of Diversity & Inclusion Initiatives Newsletter

The SKMC Council for Diversity and Inclusion (D & I) is charged with reviewing and assessing the status and effectiveness of diversity and inclusion initiatives at SKMC and makes recommendations regarding initiatives, policies, and resources needed to achieve desired outcomes. Headed by Mark L. Tykocinski, MD, the Anthony F. and Gertrude M. DePalma Dean of SKMC, and cochaired by Dr. Bernie Lopez, the Council determines the course of diversity and inclusion at SKMC with input from members who are deans, department chairs, faculty, administrators, residents and students.

Odii Student Organizations

Office of Diversity & Inclusion Initiatives Newsletter

Featuring:

• Student National Medical Association (SNMA)
• The Asian Pacific American Medical Student Association (APAMSA)
• JeffLGBTQ
• Veterans Health Initiative
• Jewish Student Association (JSA)
• Refugee Health Partners (RHP)
• Student Advisory Board
• Latino Medical Student Association (LMSA)
• Medical Spanish Translator Program

A Message From The Associate Dean For Diversity And Community Engagement, Bernard Lopez, Md

Office of Diversity & Inclusion Initiatives Newsletter

Diversity: the richness in human differences. Why is diversity important? A wide variety of experiences and points of view mean that we get to look at issues from all angles rather than just one. Inclusion: the active, intentional, and ongoing engagement with diversity. Why is inclusion important? It is not enough to have diversity - inclusion means that we value and cherish the wide variety of experiences and viewpoints. Creating and enhancing this environment is important as we set the stage to provide service to our most important customer - our patients.

Since September 2013 when I was appointed as …

Ending The Silence On Mental Illness, Anna L. Tamulonis

Purdue Journal of Service-Learning and International Engagement

NAMI on Campus at Purdue University is a collegiate branch of the national, grassroots organization called the National Alliance on Mental Illness. As an effort to address the growing need for mental health education, our organization piloted Indiana’s first Ending the Silence program. It is an educational outreach program focused on teaching local junior high and high school students about mental health through an informative and interactive curriculum. There are five volunteers, myself included, who providd this presentation to the local community. The lead presenters share 30 minutes' worth of mental health information, including warning signs of a mental health …

Student Pharmacists And Street Children: A Mutually Beneficial Relationship, Mario A. Hoyos, Monica L. Miller, Ellen M. Schellhase, C. Ryan Tomlin, Sonak Pastakia, Samuel Kimani, Tim Mercer

Purdue Journal of Service-Learning and International Engagement

The Tumaini Children’s Drop-In Center is a daytime drop-in center for the street children of Eldoret, Kenya. It is part of a partnership between the Purdue University College of Pharmacy, the Academic Model Providing Access to Healthcare program, Eldoret community members, and numerous individuals in both Kenya and the US. Through the efforts of local staff and Purdue student pharmacists, who work at the local hospital on an eight-week clinical rotation, the center has helped a population of nearly 400 local street children by providing a safe haven from life on the streets. Purdue student pharmacists aid the center by …

Developing A Mobile Application: Improving Health Care Students’ Ability To Communicate, Kiersten Walters, Ilya Rybakov, Patricia L. Darbishire

Purdue Journal of Service-Learning and International Engagement

The purpose of this project was to develop, pilot, assess, and describe a new interdisciplinary, game-based phone application. The application is intended to help health care students better communicate medication and medical terminology to their patients and to other health care providers and insurance companies. This IRB-approved project called “PharmPhrase” was developed using an application-development software program. The pilot involved multiple groups of competing teams composed of volunteer pharmacy students in their first professional years who were randomly assigned into teams of three to five. The PharmPhrase user explains a randomly generated medical term to team members based on assumptions …

A Course On Patient Safety: Pharmacy Student And Community Partner Perceptions, Maryam Noureldin, Chelsea M. Anderson, Patricia L. Darbishire

Purdue Journal of Service-Learning and International Engagement

The authors of this article developed and piloted a three-week intensive elective course for students in their third professional years in the Doctor of Pharmacy program. The goal of this course was to provide students with an opportunity to apply patient safety concepts in a real-world setting using service-learning as the pedagogy and to evaluate student perceptions of the course for potential implementation in the curriculum. Seven pharmacy students were enrolled in the pilot course and divided into three groups. Each group of two to three students was assigned to one of three predetermined community partner sites. Students were instructed …