Medicine and Health Sciences Commons^™

Sleep Quality, Sleeping Postures, And Sleeping Equipmentin Patients With Ankylosing Spondylitis, Servet Yolbaş, Ahmet Yildirim, Deccane Düzenci̇, Bariş Gündoğdu, Meti̇n Özgen, Süleyman Serdar Koca

Turkish Journal of Medical Sciences

Background/aim: Inflammatory back pain, spinal stiffness, and limited spinal mobility are characteristic features of ankylosing spondylitis (AS). Sleeping postures can affect and/or reflect sleeping disturbances. The aim of the study was to evaluate sleeping postures and sleep disturbances in patients with AS. Materials and methods: Seventy-seven patients with AS and 49 healthy controls were enrolled. The Pittsburgh Sleep Quality Index (PSQI) and the Insomnia Severity Index (ISI) were applied to both groups. The most common sleeping postures were noted. Results: There was no significant difference between the groups in terms of sleeping postures. Total PSQI and ISI scores were higher …

Evaluation Of Lipid Profiles In Patients Treated With Capecitabine, Nursel Sürmeli̇oğlu, Semra Paydaş, Yusuf Karataş, Gülşah Seydaoğlu

Turkish Journal of Medical Sciences

Background/aim: Capecitabine is a prodrug of 5-fluorouracil and has shown significant antitumor activity. The main adverse effects are hand-foot syndrome, diarrhea, and dermatitis. In recent years, hypertriglyceridemia has been reported in patients treated with capecitabine. Dyslipidemia is a rare but important side effect of capecitabine. The aim of this study is to examine the changes in lipid levels during capecitabine treatment and to raise awareness of pharmacovigilance. Materials and methods: In this retrospective study, it was aimed to analyze lipid metabolism after capecitabine treatment and is intended to contribute to the formation of a pharmacoepidemiological database. For this purpose, triglyceride, …

Antibacterial Resistance Patterns And Incidence Of Hospital-Acquired Staphylococcus Aureus Bacteremia In A Tertiary Care Educational Hospital In Turkey: A Perspective From 2001 To 2013, Oğuz Reşat Si̇pahi̇, Serhat Uysal, Sabi̇re Şöhret Aydemi̇r, Hüsnü Pullukçu, Meltem Taşbakan, Alper Tünger, Fatma Feri̇ha Çi̇lli̇, Tansu Yamazhan, Bi̇lgi̇n Arda, Hi̇lal Si̇pahi̇, Sercan Ulusoy

Turkish Journal of Medical Sciences

Background/aim: Staphylococcus aureus is an important nosocomial pathogen and a successful antimicrobial-resistance developer. In this study we retrospectively evaluated the resistance patterns and incidence of microbiologically confirmed nosocomial bacteremia (MCNB) related S. aureus strains between 2001 and 2013. Materials and methods: Any patient in whom S. aureus was isolated in at least one set of blood cultures (sent to the bacteriology laboratory 72 h after hospital admission) was considered to have MCNB. Results: The methicillin-resistant S. aureus (MRSA) rate in 2001 was 73.8% whereas it was 36.2% in 2013. When the 2001-2003 and 2011?2013 periods were compared, resistance to oxacillin, …

Tlr2 (-196 To -174 Ins/Del) And Tlr3 (1377c>T) As Biomarkers For Nasopharyngeal Cancer In Tunisia, Lamia Makni, Amira Messadi, Sabrina Zidi, Ezzedine Gazouani, Amel Mezlini, Besma Yacoubi-Loueslati

Turkish Journal of Medical Sciences

Background/aim: We evaluated the association of TLR2 (-196 to -174 Ins/Del) and TLR3 (1377 C>T) as potential risk factors for nasopharyngeal carcinoma (NPC) in Tunisians. Material and methods: The study subjects comprised 137 NPC patients and 164 cancer-free control subjects. TLR2 genotyping was done by PCR and TLR3 genotyping was performed by PCR-RFLP. Results: Minor allele frequency (MAF) and genotypes of TLR3 (1377 C>T) were comparable between NPC patients and controls. Significantly higher MAF and TLR2-containing Del allele genotypes of TLR2 (-196 to -174 Ins/Del) were seen in NPC patients compared to controls [OR (95% CI) = 2.10 …

A Nationwide Evaluation Of Off-Label Drug Utilization In Turkey, Emi̇ne Nur Özdamar, Ahmet Akici, Ali̇ Alkan, Banu Bayar, Hakki Gürsöz

Turkish Journal of Medical Sciences

Background/aim: Off-label drug use (OLDU) is under the control of the Turkish Medicines and Medical Devices Agency (TMMDA) in Turkey. It was aimed to investigate demographic and medical features of patients with OLDU applications in Turkey. Materials and methods: A total of 4426 electronic OLDU application records of the TMMDA were evaluated retrospectively. Information regarding patients? demographic characteristics, diagnoses, requested drugs, institutions, and specialties of the physicians were evaluated. Results: OLDU applications were mostly made by rheumatologists (21.5%) and 95.2% of them were approved by the TMMDA. The mean age of the patients was 35 years and 54.4% of them …

Impact Of Ggcx Polymorphisms On Warfarin Dose Requirements In Atrial Fibrillation Patients, Nian-Xin Jiang, Ying-Hui Xu, Jing-Wen Xia, Bing Jiang, Yan-Song Li

Turkish Journal of Medical Sciences

Background/aim: Warfarin is a common anticoagulant with large interindividual differences and a narrow therapeutic range. The polymorphisms of gamma-glutamyl carboxylase (GGCX) are important genetic factors for warfarin dose requirements. Materials and methods: Polymerase chain reaction and direct sequencing methods were used to detect the GGCX rs699664 genotype in 215 atrial fibrillation (AF) patients with warfarin administration. The effects on warfarin dose by different genotypes were analyzed. A warfarin dosing algorithm was developed based on age, height, CYP2C9, VKORC1, and GGCX genotype. Results: In 215 AF patients, there were 104 cases of wild-type GG genotype (48.4%), 92 cases of GA genotype …

A Fully Liquid Dtap-Ipv-Hb-Prp-T Hexavalent Vaccine For Primaryand Booster Vaccination Of Healthy Turkish Infants And Toddlers, Mehmet Ceyhan, İnci̇ Yildirim, Hasan Tezer, İlker Devri̇m, Emmanuel Feroldi

Turkish Journal of Medical Sciences

Background/aim: Immunogenicity and safety of a primary series of a fully liquid, hexavalent DTaP-IPV-HB-PRP-T vaccine given at 2, 3, and 4 months of age compared to licensed comparators and a DTaP-IPV-HB-PRP-T booster at 15?18 months were evaluated. Materials and methods: This was a Phase III, randomized, open-label trial. Primary series (no hepatitis B [HB] at birth) of DTaP-IPV-HB-PRP-T (N = 155) (group 1) or licensed control vaccines (DTaP-IPV//PRP-T and standalone HB: N = 155) (group 2) and DTaP-IPV-HB-PRP-T booster were administered. Noninferiority was evaluated 1 month postprimary series for anti-HB seroprotection (SP). All other analyses were descriptive. Safety was assessed …

Relationship Of Spinal Curvature, Mobility, And Low Back Pain In Womenwith And Without Urinary Incontinence, Şeyda Toprak Çelenay, Derya Özer Kaya

Turkish Journal of Medical Sciences

Background/aim: This study aimed to investigate the relationship of sagittal spinal curvature, mobility, and low back pain (LBP) in women with and without urinary incontinence (UI). Materials and methods: Thirty-two women with UI (incontinence group) and 41 women without UI (control group) were included in this study. The sagittal spinal curvature and mobility were assessed with a Spinal Mouse device (IDIAG, Fehraltorf, Switzerland). Urogenital symptom distress, LBP, and disability caused by LBP were assessed using the Urogenital Distress Inventory-6 (UDI-6), a visual analog scale (VAS), and the Oswestry Disability Index (ODI), respectively. Results: It was seen that the sagittal thoracic …

Plasma Human Leukocyte Antigen-G (Hla-G) In Patients With Thyroid Cancer, Murat Akin, Lati̇fe Arzu Aral, Aydin Yavuz, Harun Karabacak, Kürşat Di̇kmen, Hasan Bostanci

Turkish Journal of Medical Sciences

Background/aim: A number of tumor markers detected in the serum or pathological specimens using immunohistochemical methods are used for early detection of malignancies and postoperative follow-up. Human leukocyte antigen-G (HLA-G) is a nonclassic HLA class I molecule. Recent studies suggested a relationship between HLA-G positivity and the stage or the phenotype of the malignancy. In this study, the relationship between serum HLA-G positivity and thyroid cancer was investigated. Materials and methods: Fifty patients with thyroid cancer and 45 healthy volunteers were included in this study. Serum HLA-G levels were measured using ELISA. Results: HLA-G was positive in only 3 out …

Prevention Of Propofol Injection-Related Pain Using Pretreatment Transcutaneous Electrical Acupoint Stimulation, Luping Huang, Yuanyuan Pan, Sijia Chen, Minyuan Zhang, Xiuxiu Zhuang, Shenhui Jin, Junlu Wang, Qinxue Dai, Yunchang Mo

Turkish Journal of Medical Sciences

Background/aim: This study aimed to study the effect of pretreatment transcutaneous electrical acupoint stimulation (TEAS) in preventing propofol injection-related pain. Materials and methods: A total of 360 patients who were to undergo elective hysteroscopy surgery were randomly divided into the following three groups of 120 patients each: control (Group C), sham TEAS (Group F), and TEAS (Group T). Patients in Group C did not undergo any treatment before surgery; 30 min before the induction of anesthesia, patients in Groups F and T underwent electrical stimulation of the bilateral LI4-PC6 acupoint. Patients in Group F were subjected to 'feeling flow', while …

The Comparison Of Various Disinfectants? Efficacy On Staphylococcus Aureus And Pseudomonas Aeruginosa Biofilm Layers, Hati̇ce Köse, Nur Yapar

Turkish Journal of Medical Sciences

Background/aim: Because biofilms are resistant to antibiotics and biocides, they usually cause chronic persistent infections, which are arduous to cure and have high mortality and morbidity. Our study aimed to investigate the efficiency of orthophthalaldehyde, peracetic acid, hydrogen peroxide, and sodium hypochlorite on Pseudomonas aeruginosa and Staphylococcus aureus biofilm layers and live microbial cells. Materials and methods: Biofilm layers were determined by crystal violet assay and live microbial cells were determined using a resazurin assay. Results: For Pseudomonas aeruginosa, sodium hypochlorite showed the most influential disinfection because it diminished 83.6% of the biofilm layer and decreased 99.7% of live microbial …

The Role Of The Innate And Adaptive Immunity In Exercise Induced Muscle Damage And Repair, B Jones, G Hoyne

Health Sciences Papers and Journal Articles

The immune system plays a crucial role in regulating tissue repair processes following damage. The cellular basis of tissue repair has best been studied in toxin-induced models due to their reliability and reproducible kinetics. These models have established a crucial role for innate and adaptive immune cells that follow a temporally regulated response that begins with a proinflammatory response that is subsequently replaced by a regulatory type 2 immune response to facilitate tissue repair and restore homeostasis. Inflammation is a crucial first response to cell damage that is modulated by the response of innate lymphoid cells and tissue resident regulatory …

The Effectiveness Of Environment Assessment Tools To Guide Refurbishment Of Australian Residential Aged Care Facilities: A Systematic Review, S Neylon, C Bulsara, A Hill

Health Sciences Papers and Journal Articles

Objective: To determine applicability of environment assessment tools in guiding minor refurbishments of Australian residential aged care facilities.

Method: Studies conducted in residential aged care settings using assessment tools which address the physical environment were eligible for inclusion in a systematic review. Given these studies are limited, tools which have not yet been utilised in research settings were also included. Tools were analysed using a critical appraisal screen.

Results: Forty-three publications met the inclusion criteria. Ten environment assessment tools were identified, of which four addressed all seven minor refurbishment domains of lighting, colour and contrast, sound, flooring, furniture, signage and …

Sleep Disturbance And Serum Ferritin Levels Associate With High Impulsivity And Impulse Control Disorders In Male Parkinson's Disease Patients, R Anderton, M Byrnes, A Jefferson, S Walters, S Ghosh, R Stell, F Mastaglia

Health Sciences Papers and Journal Articles

Impulse control disorders (ICDs) occur in a subset of Parkinson’s disease (PD) patients on dopaminergic medications however there are currently no reliable markers to identify patients at risk. Sleep disturbances are more common in patients with an ICD. Serum ferritin levels have been associated with PD disease stage and progression, but have not previously been associated with impulsivity levels. The objective of this study was to determine if serum ferritin levels and sleep disturbance are associated with high traits of impulsivity and ICD in a cohort of PD patients attending a movement disorders clinic. This study assessed impulsiveness in 87 …

Impact Of Consumer Copayments For Subsidised Medicines On Health Services Use And Outcomes: A Protocol Using Linked Administrative Data From Western Australia, K Seaman, F Sanfilippo, E Roughead, M Bulsara, A Kemp-Casey, C Bulsara, G Watts, D Preen

Health Sciences Papers and Journal Articles

Introduction: Across the world, health systems are adopting approaches to manage rising healthcare costs. One common strategy is a medication copayments scheme where consumers make a contribution (copayment) towards the cost of their dispensed medicines, with remaining costs subsidised by the health insurance service, which in Australia is the Federal Government. In Australia, copayments have tended to increase in proportion to inflation, but in January 2005, the copayment increased substantially more than inflation. Results from aggregated dispensing data showed that this increase led to a significant decrease in the use of several medicines. The aim of this study is to …

Actual Competence, Rather Than Perceived Competence, Is A Better Predictor Of Physical Activity In Children Aged 6-9 Years, Fleur Mcintyre, Helen Parker, Paola Chivers, Beth Hands

Health Sciences Papers and Journal Articles

There is a limited understanding about the relative importance of perceived and actual competence on emergent physical activity levels in children and whether there is a difference in their development and strength between boys and girls.

This study used a single-cohort, multiple age group design to monitor physical activity, actual motor competence (AMC) and perceived competence (PC) on four occasions over 18 months in 6-to 9-year-old boys and girls (N = 201). Physical activity was measured by 7-day daily step counts (pedometer) and activity diary. AMC was assessed by mastery of skill criteria for 4 motor skills; run, overhand throw, …

The Improving Rural Cancer Outcomes Trial: A Cluster-Randomised Controlled Trial Of A Complex Intervention To Reduce Time To Diagnosis In Rural Cancer Patients In Western Australia, Jon D. Emery, Victoria Gray, Fiona M. Walter, Shelley Cheetham, Emma J. Croager, Terry Slevin, Christobel Saunders, Timothy Threlfall, Kirsten Auret, Anna K. Nowak, Elizabeth Geelhoed, Max Bulsara, C D'Arcy J. Holman

Health Sciences Papers and Journal Articles

Background: Rural Australians have poorer survival for most common cancers, due partially to later diagnosis. Internationally, several initiatives to improve cancer outcomes have focused on earlier presentation to healthcare and timely diagnosis. We aimed to measure the effect of community- based symptom awareness and general practice-based educational interventions on the time to diagnosis in rural patients presenting with breast, prostate, colorectal or lung cancer in Western Australia.

Methods: 2_2 factorial cluster randomised controlled trial. Community Intervention: cancer symptom awareness campaign tailored for rural Australians. GP intervention: resource card with symptom risk assessment charts and local cancer referral pathways implemented through …

Breaking Down The Barriers: Strength Training In Long Distance Triathletes, Kate M. Luckin, C Badenhorst, Ashley Cripps, G Landers, Robert Merrells, Max Bulsara, Gerard Hoyne

Health Sciences Papers and Journal Articles

INTRODUCTION: Long distance triathletes complete large endurance training volumes with approximately half reporting to including some form of strength training (ST) in their program. However, the characteristics of this ST is currently unknown. Despite not all triathletes incorporating ST, research indicates that the completion of concurrent strength and endurance training in runners, cyclists and short course triathletes can significantly improve cycling and running economy and potentially reduce injury occurrence, likely resulting in performance improvements. Previous research has hypothesised barriers to ST in endurance athletes, however there is no empirical evidence to support such hypotheses. Therefore the primary aims of …

Effects Of Screen Light Filtering Software On Sleep And Morning Alertness, Hengyu Chi

All Master's Theses

Research has shown that blue light can impact the circadian rhythm. Research has also suggested that use of electronic devices, such as computers and televisions that emit blue light before sleep, can negatively impact sleep quality. This research has led to the creation of computer software which lowers the levels of blue light in the evening to help with sleep. This study looked at the impact of wavelength filtering software on sleep onset, sleep duration and subjective alertness after morning waking of four college students. The college students were randomized into two groups and had the wavelength filtering software f.lux …

Editorial, Baby S. Nayak Dr

Manipal Journal of Nursing and Health Sciences

No abstract provided.

Effectiveness Of Pre-Operative Instruction On Knowledge, Pain, And Selected Post-Operative Behaviours Among Women Undergoing Abdominal Hysterectomy In Selected Hospital, Bangalore, Karnataka, Padma Priya S Ms, Erna Judith Roach Dr, Daisy Josphine Lobo Ms

Manipal Journal of Nursing and Health Sciences

Introduction: Women who have an abdominal hysterectomy, typically experience significant physical and psychological problems, like fear and anxiety of the surgical outcomes, post-operative pain, effect on their daily activities, and sexual relationships. Providing pre-operative information on surgery is an effective measure to promote positive post-operative outcomes. Objectives: The objectives of the study were to evaluate the effectiveness of pre-operative instruction in terms of gain in knowledge, reduction of postoperative pain and improvement in selected post-operative behaviors and to find the association between knowledge score and pain score with selected baseline variables. Methods: A quasi-experimental pre-test and post-test control group designed …

Holistic Health In Osteoarthritis: An Ayurvedic Approach, Krishna Malagi Dr, Madhusudhana Kamath Dr

Manipal Journal of Nursing and Health Sciences

The holistic approach exposed the link between ill-health and socio-economic conditions. It revealed how diet and lifestyle factors combine, to relieve the disease manifestations like osteoarthritis. Objectives: The objective of the study was to observe a holistic approach in the management of osteoarthritis and to establish significance of association between disease, diet, and lifestyle. Material and methods: The chosen strategy is suitable for preventive, curative, and promoted actions in relation to osteoarthritis. In present study, non-randomized, prospective case series methodology is adopted. The study group comprised of 20 men and women and was categorized by large similarity in the total …

Impact Of Acuity-Adaptable Rooms On Patient Outcomes: A Literature Review, Shiva Kumar T Dr, Somu G Dr, Arun M. S Dr

Manipal Journal of Nursing and Health Sciences

Introduction: According to WHO, patient safety is the prevention of errors and adverse effects to patients associated with health care. There is a significant impact of physical environment on health and patient safety. Identifying and eliminating built environment conditions that negatively impact patient safety during various phases of construction of healthcare facilities is a strong need of the hour. Methods: A comprehensive literature review retrieved 15 research articles related to acuity-adaptable patient rooms presenting evidence of the positive impact on patient safety. The literature review was focused on all the research articles, which showed impact of acuity- adaptable rooms on …

Blinding In Randomized Controlled Trials: What Researchers Need To Know?, Vishnu Renjith Mr

Manipal Journal of Nursing and Health Sciences

Randomized Controlled Trial (RCT) is a classical research design, in which the participants are randomly allocated to one or other treatment conditions under the study. Researchers widely use randomized trials to evaluate the effectiveness of various pharmacological and non-pharmacological interventions. At the outset, randomization minimizes the bias in allocating subjects to the intervention and control group. However, it does not exclude the chances of differential treatment of groups or biased adjudication of outcome variables. Blinding helps in controlling various types of biases that might inadvertently sweep into the study. The two major biases that can be controlled using blinding are …

Identified Stressors And Coping Mechanisms Of Occupational Therapy Students, Amy Fitzsimmons, Ashley Zimmer

Occupational Therapy Capstones

Introduction: The purpose of this research study was to gather data on stressors experienced by occupational therapy students during their program and how they cope with their identified stressors. The rationale for this study was the lack of and inconsistent research regarding occupational therapy students, how they experience perceived psychological stress during their program, and how they cope with their identified stressors.

Methodology: The researchers utilized a quantitative exploratory survey design to discover perceived psychological stress and coping methods in Master’s of Occupational Therapy (MOT) students. Prior to recruitment, Institutional Review Board (IRB) approval was received. Respondents were recruited through …

Preparing Occupational Therapists For Treatment Of The Transgender Population: A Training Guide For Supportive Care, Nicola Grun, Lauren Trohkimoinen

Occupational Therapy Capstones

Throughout current literature, it is clear that people who identify as transgender face larger percentages of occupational injustice and deprivation than people who identify with the sex they were assigned at birth (Bar, Jarus, Wada, Rechtman, & Noy, 2016; Twinley, 2014). There is no occupational therapy specific research or client-specific programming for transgender people (Beagan, Chiasson, Fiske, Forseth, Hosein, Myers & Stang, 2013), which indicates the need for supportive care for this population. The purpose of this scholarly project is to develop a training guide to prepare occupational therapists to provide supportive care for the transgender population. The Ecology of …

Promoting Interdisciplinary Collaboration Across School Contexts: A Toolkit For Occupational Therapists, Sidney Luers, Shayna Shaffer

Occupational Therapy Capstones

The purpose of this project was to create a toolkit for occupational therapists who work within the elementary school settings to promote collaboration with teachers and other school personnel. In recent years there has been an increase in children who qualify for occupational therapy services within the school, which creates a need for collaboration with occupational therapists and teachers. Kennedy and Stewart (2011) found that while occupational therapists and teachers desire a collaborative relationship, there is little evidence supporting a way to achieve effective collaboration between the professions.

An extensive literature review was conducted in order to acquire information to …

Educating Caregivers In Assisted Living Facilities (Alfs) Who Care For People With Dementia, Rodney Palmer, Ashley Palmer

Occupational Therapy Capstones

It is estimated that approximately 40-71% of residents living within assisted living facilities (ALFs) have a form of dementia or other cognitive impairment (Harris- Kojetin et al., 2016; Zimmerman, Sloana, & Reed, 2014). There is also evidence that suggests that caregivers working within ALFs have inadequate knowledge on how to care for a resident diagnosed with dementia (Hughes, Bagley, Reilly, Burns, & Challis, 2008; McKenzie, Teri, Pike, LaFazia, & Van Leynseele, 2012; Sharpp, Kayser-Jones, & Young, 2012; Zimmerman et al., 2014). The authors of this scholarly project created an instructional manual that can be used to train caregivers within ALFs …

Evolution Of Occupational Therapy Practice: Life History Of Cassady Hoff Ms Otr/L, Danielle Chartier, Amanda Callahan

Oral History Posters

This life history is one of twenty nine life history interviews which are a part of a larger project, Life Histories of Individuals Who Have Been Influential in Developing Occupational Therapy (OT) in North Dakota and Wyoming. The purpose of the project is to gather information about the history and evolution of occupational therapy (OT) practice in North Dakota and Wyoming through life histories of individuals who have been influential in developing OT in these two states. It is anticipated that the life history process will be a powerful way to gather this information. This study is intended to provide …

Life History Of Dr. Sheri Montgomery, Ort/L, Otd, Mikaela Karpen, Stacy Sigmond

Oral History Posters

This life history one of 29 life history interviews that are a part of a larger project, Life Histories of Individuals Who Have Been Influential in Developing Occupational Therapy (OT) in North Dakota and Wyoming. The purpose of the project is to gather information about the history and evolution of occupational therapy (OT) practice in North Dakota and Wyoming through life histories of individual who have been influential in developing OT in these two state. It is anticipated that the life history process will be a powerful way to gather this information. This study is intended to provide current and …