Medicine and Health Sciences Commons^™

Nutrient Content Of Summer-Planted Oats After Corn Harvest And Grazing Performance, Kristen M. Ulmer, Robert G. Bondurant, Jana L. Gramkow Gramkow, Mary E. Drewnoski, James C. Macdonald

Nebraska Beef Cattle Reports

Annual forages provide producers with an alternative grazing source in the fall. A cover crop grazing study was conducted following corn harvest to evaluate the steer ADG and yield of summer sown oats and turnips planted after either high moisture corn or corn silage production. Th e gain of steers grazing oats aft er silage was 1.29 lb/day, while the gain of steers grazing corn residue and oats aft er high moisture corn was 0.72 lb/day. Average oat forage production aft er silage harvest was 2857 lb/acre, while oat production following corn harvest was 523 lb/ acre. Fall forage production …

Statistics Used In The Nebraska Beef Report And Their Purpose

Nebraska Beef Cattle Reports

The purpose of beef cattle and beef product research at UNL is to provide reference information that represents the various populations (cows, calves, heifers, feeders, carcasses, retail products, etc) of beef production. Obviously, the researcher cannot apply treatments to every member of a population; therefore he/ she must sample the population. The use of statistics allows the researcher and readers of the Nebraska Beef report the opportunity to evaluate separation of random (chance) occurrences and real biological effects of a treatment. Following is a brief description of the major statistics used in the beef report. For a more detailed description …

Effect Of Heifer Development System On Reproduction And Subsequent Gain As A Pregnant Heifer, Shelby A. Springman, Hazy Rae Nielson, Tonya L. Meyer, Mike Kirby, Jim Teichert, Richard N. Funston

Nebraska Beef Cattle Reports

Weaned heifers grazed corn residue, upland range, or were fed 1 of 2 drylot diets differing in energy. Heifer development diets did not impact their resulting AI or final pregnancy rates. Cost per pregnant heifer was similar among treatments. A subset of AI- pregnant heifers was placed in a Calan Broadbent individual feeding system during late gestation. As a pregnant heifer, feed efficiency was not impacted by development system. These results indicate producers may utilize their most readily available and/or cost- effective feed resources with no detriment to pregnancy rates or feed efficiency as first- calf heifers.

Effect Of Three Initial Implant Programs With A Common Terminal Revalor®- 200 On Feedlot Performance And Carcass Traits Of Weaned Steers, Colton R. Oney, Galen E. Erickson, Andrea K. Watson Watson, Marshall N. Streeter, Robert J. Cooper, Bill D. Dicke, D. J. Jordon, Tony L. Scott

Nebraska Beef Cattle Reports

A commercial feedlot study utilizing 1,350 calf- fed steers (initial BW = 623 lb; ±23 lb) compared three initial implant strategies: Revalor®- IS (day 1), Revalor®- IS (day 1) and Revalor®- 200 (day 67), or Revalor®- XS (day 1). Each initial implant strategy was followed by a terminal Revalor®- 200 implant (day 133) to determine effects on performance and carcass traits. No differences in final body weight, intake, gain, or feed conversion were observed on either a live, or carcass adjusted basis. Th ere were also no differences in hot carcass weight, USDA quality grade, or USDA yield grade. Results …

The Antihypertensive Mthfr Gene Polymorphism Rs17367504-G Is A Possible Novel Protective Locus For Preeclampsia, Liv Cecilie V. Thomsen, Nina S. Mccarthy, Phillip E. Melton, Gemma Cadby, Rigmor Austgulen

School of Medicine Publications

Objective:

Preeclampsia is a complex heterogeneous disease commonly defined by new-onset hypertension and proteinuria in pregnancy. Women experiencing preeclampsia have increased risk for cardiovascular diseases (CVD) later in life. Preeclampsia and CVD share risk factors and pathophysiologic mechanisms, including dysregulated inflammation and raised blood pressure. Despite commonalities, little is known about the contribution of shared genes (pleiotropy) to these diseases. This study aimed to investigate whether genetic risk factors for hypertension or inflammation are pleiotropic by also being associated with preeclampsia.

Methods:

We genotyped 122 single nucleotide polymorphisms (SNPs) in women with preeclampsia (n = 1006) and nonpreeclamptic controls …

The Little Big Genome: The Organization Of Mitochondrial Dna, Iraselia Garcia, Edith Jones, Manuel Ramos, Wendy Innis-Whitehouse, Robert Gilkerson

School of Medicine Publications

The small (16,569 base pair) human mitochondrial genome plays a significant role in cell metabolism and homeostasis. Mitochondrial DNA (mtDNA) contributes to the generation of complexes which are essential to oxidative phosphorylation (OXPHOS). As such, mtDNA is directly integrated into mitochondrial biogenesis and signaling and regulates mitochondrial metabolism in concert with nuclear-encoded mitochondrial factors. Mitochondria are a highly dynamic, pleiomorphic network that undergoes fission and fusion events. Within this network, mtDNAs are packaged into structures called nucleoids which are actively distributed in discrete foci within the network. This sensitive organelle is frequently disrupted by insults such as oxidants and inflammatory …

Emotions, Intuitions And Risk Perception In Critical Care, Oleksandr Dubov

Electronic Theses and Dissertations

The theory of decision-making as it applies to bioethics and healthcare assumes a rational decision maker: someone who knows all his alternatives, has clear preferences, can rank and weigh risks and benefits of an intervention, and always acts in his own best interests. However, the growing body of research from the field of decision science shows that, in reality, such a purely rational decision maker does not exist. Instead, patients are rational within personal or environmental constraints such as uncertainty or ambiguity in which non-rational approaches such as emotion and intuition are instrumental. This issue is particularly important in critical …

Parents Of Children Who Had Hypoxic-Ischemic Encephalopathy: A Mixed-Methods, Exploratory Study, Natalene Kramer

Electronic Theses and Dissertations

Background: There is scant literature addressing the parents of children who had hypoxic-ischemic encephalopathy (HIE). therefore only inferences may be made as to issues of that experience affecting parents.

Purpose: The purposes of this study was to uncover the lived experiences of parents of children who had HIE, evaluate issues of stress, depression, coping, and impact of neurologic disability in order to better care for them and thus their families

Methods: A parallel, convergent mixed-methods design was used to explore experiences and perceptions of these parents regarding their experiences and life changes. The quantitative strand addressed four research questions which …

Maine Medical Center Research Institute: 2017 Year In Review, Maine Medical Center Research Institute

Annual Reports

Annual Report: Bench to Bedside to Community, Basic Research->Translational & Clinical Research->Patient-Centered Outcomes Research

An Organizational Ethics Framework To Balance Individual Privacy And Population Interests Regarding Genetic Technologies, Christine Trani

Electronic Theses and Dissertations

The American culture holds the right to privacy as one of the most esteemed rights for individuals. As such, the culture adamantly defends the right to privacy to ensure individuals have the opportunity to live freely. In the American healthcare system, the right to privacy is critical for individual autonomy. However, genetic science has pushed this boundary as it emphasizes the interdependency between individual and population health. Genetic technologies for healthcare have been increasing at an exponential rate since the early 2000s. Their implantation into clinical care has been a slower process due to ethical dilemmas. Specifically, ethical dilemmas revolve …

The Experience Of Peer Mentors Within A Peer Mentor Postsecondary Transition Program, Carissa Birchem, Mikayla Greely, Suzanna Morrison

Occupational Therapy Capstones

Peer mentorship programs are one approach to assist students with disabilities to be more successful within a college community. One such program is the Student Organization for Accessibility and Resources (SOAR) which focuses on the occupations of education, social participation, and leisure activities in conjunction with assisting students in identifying available resources. However, there is limited understanding regarding these types of programs. The purpose of this study was to gain an understanding of the student peer mentor’s overall experience, how the environment affected their experience, and the occupation of peer mentorship. Researchers utilized a phenomenological qualitative research method completing six …

A Home Away From Home: An Occupational Manual For Working With Refugee Populations, Katherine Erickson, Kari Kjergaard

Occupational Therapy Capstones

Problem: As of October 2016, over 65.3 million people have been displaced from their home due to civil wars and civil unrest; 21.3 million of this population are refugees and this number continues to grow (UNHCR, 2016). Due to the nature in which people become refugees and experience trauma, both physically and mentally, there is a rising need for health professionals to be culturally competent and well equipped to work with this population. The vast majority of refugee populations face barriers some of which include being forced to adapt to a new home environment, social isolation, language barriers, and ultimately …

Sexuality And Healthcare: The Perceptions Of Providers Regarding Role Delineation: Are Occupational Therapists Overlooked?, Brooke Friederichs, Olivia Isaacson

Occupational Therapy Capstones

INTRODUCTION: The responsibility to address sexual activity is not clearly delineated to one certain healthcare profession, and therefore it often goes unaddressed (Rimmer et al., 2010). In addition, there is an overall lack of literature regarding the extent to which healthcare providers understand the role of occupational therapy in addressing sexual activity.

OBJECTIVES: The purpose of the study was to explore 1) how healthcare providers (physical therapists, occupational therapists, and registered nurses) perceive role delineation when addressing patient concerns about sexual activity 2) the level to which physical therapists and registered nurses believe sexual activity is outlined in the scope …

Perceptions Of Wellness Among Community Dwelling Older Adults, Sara Johnson, April Schmiesing

Occupational Therapy Capstones

Most older adults prefer to age in place where they are more likely to experience greater health benefits and cost savings as opposed to living in skilled care facilities. Literature supports the role of occupational therapy in community-based wellness programming that helps older adults age in place; however, there is a need to conduct needs assessments to inform wellness program topics and activities. This study explores health and wellness needs of older adults living in a low-income, senior housing complex in order to inform current health and wellness programming provided at this site.

Researchers used a non-experimental, cross-sectional survey study …

The Effects Of Perinatal Oxycodone Exposure On The Stress Axis And Neurobehavior, Thitinart Sithisarn

Theses and Dissertations--Physiology

Opiate addiction is now a major public health problem. Pregnant women continue to use opiates during gestation; up to 5.4% of pregnant women report using illicit drugs during pregnancy. Previous studies have shown that perinatal insults and exposure to opiates such as morphine in utero can affect the development of the hypothalamic-pituitary-adrenal (HPA)-axis of the offspring and are associated with higher risk of developing neurobehavioral problems. Oxycodone, a semisynthetic putative kappa opioid receptor and partial mu opioid receptor agonist is now one of the most frequently abused pain killers during pregnancy, however limited data are available regarding whether and how …

The Mechanical Properties Of Non-Failing And Failing Human Myocardium, Cheavar A. Blair

Theses and Dissertations--Physiology

Heart failure is a clinical syndrome that manifests when there are structural and functional impairments to the heart that reduces the ability of the ventricles to fill or eject blood. The syndrome affects ~6 million Americans and is responsible for nearly 300,000 deaths annually. At the core of the syndrome are dysfunctional sarcomeres, the machinery that drives cardiac contraction and relaxation. By assessing the mechanical properties of human cardiac tissue, the information provided in this dissertation will provide data that demonstrates how sarcomeric dysfunction contributes to heart failure in the left and right ventricles. Additionally, these data will supply information …

Human Tear Fluid Reduces Culturability Of Contact Lens-Associated Pseudomonas Aeruginosa Biofilms But Induces Expression Of The Virulence-Associated Type Iii Secretion System, Yvonne T. Wu, Connie Tam, Lucia S. Zhu, David J. Evans, Suzanne M. J. Fleiszig

Faculty Publications & Research of the TUC College of Pharmacy

Purpose

The type III secretion system (T3SS) is a significant virulence determinant for Pseudomonas aeruginosa. Using a rodent model, we found that contact lens(CL)-related corneal infections were associated with lens surface biofilms. Here, we studied the impact of human tear fluid on CL-associated biofilm growth and T3SS expression.

Methods

P. aeruginosa biofilms were formed on contact lenses for up to 7 days with or without human tear fluid, then exposed to tear fluid for 5 or 24 h. Biofilms were imaged using confocal microscopy. Bacterial culturability was quantified by viable counts, and T3SS gene expression measured …

Anti-Inflammatory And Neuroprotective Role Of Natural Product Securinine In Activated Glial Cells: Implications For Parkinson’S Disease, Dmitri Leonoudakis, Anand Rane, Suzanne Angeli, Gordon J. Lithgow, Julie K. Andersen, Shankar J. Chinta

Faculty Publications & Research of the TUC College of Pharmacy

Glial activation and subsequent release of neurotoxic proinflammatory factors are believed to play an important role in the pathogenesis of several neurological disorders including Parkinson’s disease (PD). Inhibition of glial activation and inflammatory processes may represent a therapeutic target to alleviate neurodegeneration. Securinine, a major natural alkaloid product from the root of the plant Securinega suffruticosa, has been reported to have potent biological activity and is used in the treatment of neurological conditions such as amyotrophic lateral sclerosis, poliomyelitis, and multiple sclerosis. In this study, we explored the underlying mechanisms of neuroprotection elicited by securinine, particularly its anti-inflammatory effects …

Mucosal Fluid Glycoprotein Dmbt1 Suppresses Twitching Motility And Virulence Of The Opportunistic Pathogen Pseudomonas Aeruginosa, Jianfang Li, Matteo E. O. Metruccio, David J. Evans, Suzanne M. J. Fleiszig

Faculty Publications & Research of the TUC College of Pharmacy

It is generally thought that mucosal fluids protect underlying epithelial surfaces against opportunistic infection via their antimicrobial activity. However, our published data show that human tear fluid can protect against the major opportunistic pathogen Pseudomonas aeruginosa independently of bacteriostatic activity. Here, we explored the mechanisms for tear protection, focusing on impacts of tear fluid on bacterial virulence factor expression. Results showed that tear fluid suppressed twitching motility, a type of surface-associated movement conferred by pili. Previously, we showed that twitching is critical for P. aeruginosa traversal of corneal epithelia, exit from epithelial cells after internalization, and corneal virulence. Inhibition …

Relationship Between Grit With Academic Performance And Attainment Of Postgraduate Training In Pharmacy Students, Adrian Jason L. Palisoc, Rae Reiko Matsumoto, Jackie Ho, Paul J. Perry, Terrill T. Tang, Eric J. Ip

Faculty Publications & Research of the TUC College of Pharmacy

Objective. To determine if Grit-S scores correlate with academic success in a doctor of pharmacy (PharmD) program, as well as the pursuit and attainment of pharmacy postgraduate (residency or fellowship) training.

Methods. A 28-item survey was administered to third- and fourth-year (P3 and P4) pharmacy students. Variables queried included Grit-S score, demographics, pharmacy experience prior to the PharmD program, and factors that may affect academic performance during didactic coursework. Didactic coursework GPA was used as a surrogate for academic success. Information about pursuit and attainment of a postgraduate training position was also documented and used in the analyses. …

A First Look At The Microbial Community Of Rabidosa Rabida, A Wolf Spider In Searcy, Arkansas, Patricia Rivera, Ryan Stork, Amber Hug

Journal of the Arkansas Academy of Science

Many diverse animal models have been used to explore the interactions between host organisms and their microbiota. Increased understanding of microbe-host interactions could lead to improved healthcare and drug development. Spiders have venom, digestive fluid, and body fluid components that have been suggested to possess antimicrobial properties that could lead to new and interesting host-microbe interactions. While studies have been published on interactions between bacteria affecting the immune function and behavior of spiders, the spider microbiome has not been established to date. Excreta and body swabs were collected from Rabidosa rabida, a wolf spider typically found on tall grass …

Simulating Foodborne Pathogens In Poultry Production And Processing To Defend Against Intentional Contamination, S. Lankford, D. R. Thompson, S. C. Ricke

Journal of the Arkansas Academy of Science

There is a lack of data in recent history of food terrorism attacks, and as such, it is difficult to predict its impact. The food supply industry is one of the most vulnerable industries for terrorist threats while the poultry industry is one of the largest food industries in the United States. A small food terrorism attack against a single poultry processing center has the potential to affect a much larger human population than its immediate consumers. In this work, the spread of foodborne pathogens is simulated in a poultry production and processing system to defend against intentional contamination. An …

Similar Adverse Events From Two Disparate Agents Implicate Lipid Inflammatory Mediators For A Role In Anxiety States, Gordon Mccarter, Lauren B. Blanchard

Faculty Publications & Research of the TUC College of Pharmacy

We recently reported a case in which a 54-year-old male experienced maintenance insomnia, generalized anxiety and panic symptoms associated with consumption of a fish oil supplement enriched in eicosapentaenoic acid (EPA). We report here that the same patient has experienced identical but more severe symptoms in response to the use of the leukotriene receptor antagonist montelukast, in accordance with other cases reported to the Food and Drug Administration. Since omega-3 fatty acids like EPA are precursors for the biosynthesis of eicosanoids including leukotrienes, a common factor to these psychiatric adverse events may be perturbations in this highly complex system of …

Visualizing Morphogenesis With The Processing Programming Language, Avik Patel, Amar Bains, Richard Millet, Tamira Elul

Faculty Publications & Research of the TUC College of Osteopathic Medicine

We used Processing, a visual artists’ programming language developed at MIT Media Lab, to simulate cellular mechanisms of morphogenesis – the generation of form and shape in embryonic tissues. Based on observations of in vivo time-lapse image sequences, we created animations of neural cell motility responsible for elongating the spinal cord, and of optic axon branching dynamics that establish primary visual connectivity. These visual models underscore the significance of the computational decomposition of cellular dynamics underlying morphogenesis.

Piwi Is Required To Limit Exhaustion Of Aging Somatic Stem Cells, Pedro Sousa-Victor, Arshad Ayyaz, Rippei Hayashi, Yanyan Qi, David T. Madden, Victoria V. Lunyak, Heinrich Jasper

Faculty Publications & Research of the TUC College of Pharmacy

Please see the graphical abstract in the supplemental files.

Contributions Of Myd88-Dependent Receptors And Cd11c-Positive Cells To Corneal Epithelial Barrier Function Against Pseudomonas Aeruginosa, Matteo M. E. Metruccio, Connie Tam, David J. Evans, Anna L. Xie, Michael E. Stern, Suzanne M. J. Fleiszig

Faculty Publications & Research of the TUC College of Pharmacy

Previously we reported that corneal epithelial barrier function against Pseudomonas aeruginosa was MyD88-dependent. Here, we explored contributions of MyD88-dependent receptors using vital mouse eyes and confocal imaging. Uninjured IL-1R (−/−) or TLR4 (−/−) corneas, but not TLR2 (−/−), TLR5 (−/−), TLR7 (−/−), or TLR9 (−/−), were more susceptible to P. aeruginosa adhesion than wild-type (3.8-fold, 3.6-fold respectively). Bacteria adherent to the corneas of IL-1R (−/−) or TLR5 (−/−) mice penetrated beyond the epithelial surface only if the cornea was superficially-injured. Bone marrow chimeras showed that bone marrow-derived cells contributed to IL-1R-dependent barrier function. In vivo, but not ex vivo …

An Analysis Of California Pharmacy And Medical Students' Dietary And Lifestyle Practices, Nathalie Bergeron, Sebastian Al-Saiegh, Eric J. Ip

Faculty Publications & Research of the TUC College of Pharmacy

Objective. To assess dietary and lifestyle practices of pharmacy and medical students in California and investigate whether they adhered to behaviors consistent with current dietary and exercise guidelines.

Methods. The Block Brief 2000 Food Frequency Questionnaire and a supplemental survey assessing demographics, exercise, and dietary behaviors were administered to students across 10 California pharmacy and medical schools.

Results. While the majority of students consumed sodium/day (73%) and dietary cholesterol/day (84%), only 50% had a saturated fat intake ≤10% total kcal, 13% met fiber intake goals, 10% consumed ≥8 servings/day of fruit and vegetables, and 41% exercised ≥150 minutes/week. The largest …

Components Of A Measure To Describe Organizational Culture In Academic Pharmacy, Shane P. Desselle, Meagen Rosenthal, Erin R. Holmes, Brienna Andrews, Julia Lui, Leela Raja

Faculty Publications & Research of the TUC College of Pharmacy

Objective. To develop a measure of organizational culture in academic pharmacy and identify characteristics of an academic pharmacy program that would be impactful for internal (eg, students, employees) and external (eg, preceptors, practitioners) clients of the program.

Methods. A three-round Delphi procedure of 24 panelists from pharmacy schools in the U.S. and Canada generated items based on the Organizational Culture Profile (OCP), which were then evaluated and refined for inclusion in subsequent rounds. Items were assessed for appropriateness and impact.

Results. The panel produced 35 items across six domains that measured organizational culture in academic pharmacy: competitiveness, …

Steroid Hormone Receptors As Prognostic Markers In Breast Cancer, Maggie C. Louie, Mary B. Sevigny

Faculty Publications & Research of the TUC College of Pharmacy

Despite the existence of many promising anti-cancer therapies, not all breast cancers are equally treatable, due partly to the fact that focus has been primarily on a few select breast cancer biomarkers- notably ERα, PR and HER2. In cases like triple negative breast cancer (ERα-, PR-, and HER2-), there is a complete lack of available biomarkers for prognosis and therapeutic purposes. The goal of this review is to determine if other steroid receptors, like ERβ and AR, could play a prognostic and/or therapeutic role. Data from various in vitro, in vivo, and clinical breast cancer studies were examined …

Single Low-Dose Lipopolysaccharide Preconditioning: Neuroprotective Against Axonal Injury And Modulates Glial Cells, Ryan C. Turner, Zachary J. Naser, Brandon P. Lucke-Wold, Aric F. Logsdon, Reyna L. Vangilder, Rae Reiko Matsumoto, Jason D. Huber

Faculty Publications & Research of the TUC College of Pharmacy

AIM: Over 7 million traumatic brain injuries (TBI) are reported each year in the United States. However, treatments and neuroprotection following TBI are limited because secondary injury cascades are poorly understood. Lipopolysaccharide (LPS) administration before controlled cortical impact can contribute to neuroprotection. However, the underlying mechanisms and whether LPS preconditioning confers neuroprotection against closed-head injuries remains unclear.

METHODS: The authors hypothesized that preconditioning with a low dose of LPS (0.2 mg/kg) would regulate glial reactivity and protect against diffuse axonal injury induced by weight drop. LPS was administered 7 days prior to TBI. LPS administration reduced locomotion, which recovered completely …