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2017

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Articles 11551 - 11580 of 14524

Full-Text Articles in Medicine and Health Sciences

The Effect Of Trimetazidine On Renal Oxidative Stress In Partialand Complete Ureteral Obstructions In A Rat Model, Sema Nur Ayyildiz, Ali̇ Ayyildiz, Erdal Benli̇, Selma Cirrik, Rüştü Cankon Germi̇yanoğlu, Tevfi̇k Noyan, Abdullah Çirakoğlu Jan 2017

The Effect Of Trimetazidine On Renal Oxidative Stress In Partialand Complete Ureteral Obstructions In A Rat Model, Sema Nur Ayyildiz, Ali̇ Ayyildiz, Erdal Benli̇, Selma Cirrik, Rüştü Cankon Germi̇yanoğlu, Tevfi̇k Noyan, Abdullah Çirakoğlu

Turkish Journal of Medical Sciences

Background/aim: Renal oxidative stress occurs in ureteral obstructions. The purpose of this study was to investigate the effect of the antioxidant and antiischemic agent trimetazidine (TMZ) on oxidative stress following ureteral obstruction. Materials and methods: Ten groups were established. Sham groups were checked as controls after 1 and 3 weeks. The other 8 groups had partial or complete ureteral obstruction while receiving or not receiving trimetazidine (TMZ) at 5 mg/kg daily and were evaluated after either 1 week or 3 weeks. Creatinine and cystatin C measurements were performed in the serum. Malondialdehyde, myeloperoxidase, catalase, and glutathione peroxidase activity were measured …

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The Effects Of Iloprost And Alprostadil On Ischemia-Reperfusion Injury In Preventing Inflammation, Tissue Degeneration, And Apoptosis In Rat Skeletal Muscle, Eli̇f Güneysu, Atacan Emre Koçman, Orhan Özati̇k, Cengi̇z Ovali, Betül Can, İbrahi̇m Özkan Alataş, Mustafa Behçet Sevi̇n Jan 2017

The Effects Of Iloprost And Alprostadil On Ischemia-Reperfusion Injury In Preventing Inflammation, Tissue Degeneration, And Apoptosis In Rat Skeletal Muscle, Eli̇f Güneysu, Atacan Emre Koçman, Orhan Özati̇k, Cengi̇z Ovali, Betül Can, İbrahi̇m Özkan Alataş, Mustafa Behçet Sevi̇n

Turkish Journal of Medical Sciences

Background/aim: The protective effects of prostaglandin (PG) analogs on ischemia-reperfusion (I/R) have been well documented; however, comparative studies are lacking. The aim of the present study was to determine whether iloprost or alprostadil is more effective in preventing muscle I/R injury. Materials and methods: Thirty-two rats were divided into four groups (n = 8): sham, control, IL (I/R + iloprost), and AL (I/R + alprostadil). I/R was induced by a tourniquet in the hindlimb for 3 h/3 h. The IL and AL groups received iloprost (0.5 ng kg-1 min-1) and alprostadil (0.05 μg kg-1 min-1) during reperfusion, respectively. After 6 …

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Impact Of Body Mass Index, Waist Circumference And Pfannenstiel Sitetissue Thickness, And Elastosonography On Operative Parameters, Serap Gülteki̇n, İsmai̇l Burak Gülteki̇n, Zehra Vural Yilmaz, Bi̇lal İçer, Afra Alkan, Tuncay Küçüközkan Jan 2017

Impact Of Body Mass Index, Waist Circumference And Pfannenstiel Sitetissue Thickness, And Elastosonography On Operative Parameters, Serap Gülteki̇n, İsmai̇l Burak Gülteki̇n, Zehra Vural Yilmaz, Bi̇lal İçer, Afra Alkan, Tuncay Küçüközkan

Turkish Journal of Medical Sciences

Background/aim: This study aimed to evaluate the impact of body fat distribution measured by body mass index (BMI), waist circumference (WC) and Pfannenstiel incision site tissue thickness, and elastosonography on bleeding and operation time during cesarean delivery.Materials and methods: A prospective study was made of 52 healthy, term pregnant women with prior cesarean deliveries. The impact of BMI, WC, incision site thickness, and elastosonography on preoperative and postoperative differences in hemoglobin (Hb) and hematocrit (Htc) levels and operation times was evaluated.Results: A moderate negative relationship was found between Htc levels and WC. Htc levels were found to decrease by 0.148 …

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The Effect Of Antidiuretic Hormone On Urine And Serum Electrolyte Levelsin Children With Primary Monosymptomatic Nocturnal Enuresis, Nesri̇n Taş, Yaşar Kandur, Hati̇ce Ki̇bri̇ya Fi̇dan, Hüsnü Oğuz Söylemezoğlu Jan 2017

The Effect Of Antidiuretic Hormone On Urine And Serum Electrolyte Levelsin Children With Primary Monosymptomatic Nocturnal Enuresis, Nesri̇n Taş, Yaşar Kandur, Hati̇ce Ki̇bri̇ya Fi̇dan, Hüsnü Oğuz Söylemezoğlu

Turkish Journal of Medical Sciences

Background/aim: The data concerning the effects of desmopressin on water/electrolyte disturbances of children with primary monosymptomatic nocturnal enuresis (PMNE) are limited. In the present study we aimed to evaluate the effect and tolerability of desmopressin on blood and urine electrolytes and osmolality in PMNE.Materials and methods: Thirty-five children with PMNE between the ages of 5 and 15 participated in the study. Patients collected urine during the daytime and acknowledged the night time fluid restriction before starting to use the desmopressin tablets. The medication was taken orally at least 1 h before bedtime. Blood and urine samples were collected before the …

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Relationship Between Kinesiophobia And Pain, Quality Of Life, Functional Status, Disease Activity, Mobility, And Depression In Patients With Ankylosing Spondylitis, Deran Oskay, Zeynep Tuna, İrem Düzgün, Bülent Elbasan, Yavuz Yakut, Abdurrahman Tufan Jan 2017

Relationship Between Kinesiophobia And Pain, Quality Of Life, Functional Status, Disease Activity, Mobility, And Depression In Patients With Ankylosing Spondylitis, Deran Oskay, Zeynep Tuna, İrem Düzgün, Bülent Elbasan, Yavuz Yakut, Abdurrahman Tufan

Turkish Journal of Medical Sciences

Background/aim: Our aim was to investigate the association of kinesiophobia with pain, quality of life, clinical measures, and depression in patients with ankylosing spondylitis (AS). Materials and methods: Patients with AS (n: 163) were enrolled in the study. Kinesiophobia was evaluated with the Tampa Scale of Kinesiophobia (TSK), pain with a visual analog scale (VAS), mobility with Bath Ankylosing Spondylitis Metrology Index (BASMI), disease activity with the Bath AS Disease Activity Index (BASDAI), functional status with the Bath AS Functional Index (BASFI), depression level with Beck's Depression Inventory (BDI), and quality of life with the AS Quality of Life Questionnaire …

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Egfr, Kras, And Braf Mutational Profiles Of Female Patients With Micropapillary Predominant Invasive Lung Adenocarcinoma, Funda Demi̇rağ, Aydin Yilmaz, Ni̇lgün Yilmaz Demi̇rci̇, Ülkü Yilmaz, Yurdanur Erdoğan Jan 2017

Egfr, Kras, And Braf Mutational Profiles Of Female Patients With Micropapillary Predominant Invasive Lung Adenocarcinoma, Funda Demi̇rağ, Aydin Yilmaz, Ni̇lgün Yilmaz Demi̇rci̇, Ülkü Yilmaz, Yurdanur Erdoğan

Turkish Journal of Medical Sciences

Background/aim: This study aimed to analyze EGFR, KRAS, and BRAF mutations in females with micropapillary predominant invasive lung adenocarcinoma and their relationships with immunohistochemical and clinicopathological patterns.Materials and methods: A total of 15 females with micropapillary lung adenocarcinoma were selected. Mutational analysis of the EGFR, KRAS, and BRAF genes was carried out. Information regarding the demographic data, tumor size, treatment, and survival time for each patient was collated, and the predominant cell type, secondary architectural growth patterns, psammoma bodies, necrosis, and visceral pleural and angiolymphatic invasions were evaluated.Results: We identified EGFR mutation in six cases, KRAS mutation in three cases, …

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Evaluation Of Risk Factors For The Recurrence Of Colorectal Polyps And Colorectal Cancer, Öztürk Ateş, Bülent Si̇vri̇, Saadetti̇n Kiliçkap Jan 2017

Evaluation Of Risk Factors For The Recurrence Of Colorectal Polyps And Colorectal Cancer, Öztürk Ateş, Bülent Si̇vri̇, Saadetti̇n Kiliçkap

Turkish Journal of Medical Sciences

Background/aim: Colorectal adenomatous polyps are precursors of colorectal cancer (CRC), which can be prevented with surveillance colonoscopy. This study aimed to assess risk factors for the recurrence of colorectal polyps and CRC following polypectomy. Materials and methods: In this single-center trial, a total of 510 patients who applied to the endoscopy unit of Hacettepe University Hospital for various reasons and who were diagnosed with at least one colorectal adenomatous polyp between 2000 and 2010 were retrospectively analyzed. Patients with colorectal adenomatous polyps or CRC recurrences were examined in terms of clinical and histological risk factors. Results: A total of 190 …

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Unknown Vascular Compression Of The Airway In Patients With Congenitalheart Disease And Persistent Lower Respiratory Symptoms, Tuğba Şi̇şmanlar Eyüboğlu, Ayşe Tana Aslan, Çi̇ğdem Öztunali, Fatma Sedef Tunaoğlu, Ayşe Deni̇z Oğuz, Serdar Kula, Betül Emi̇ne Deri̇nkuyu, Öznur Leman Boyunaga Jan 2017

Unknown Vascular Compression Of The Airway In Patients With Congenitalheart Disease And Persistent Lower Respiratory Symptoms, Tuğba Şi̇şmanlar Eyüboğlu, Ayşe Tana Aslan, Çi̇ğdem Öztunali, Fatma Sedef Tunaoğlu, Ayşe Deni̇z Oğuz, Serdar Kula, Betül Emi̇ne Deri̇nkuyu, Öznur Leman Boyunaga

Turkish Journal of Medical Sciences

Background/aim: Airway compression (AC) by vascular structures is an important complication of congenital heart disease (CHD) that often goes unrecognized. It is not easy to identify whether CHD patients require additional invasive examinations or not. Therefore, the present study aims to develop an AC diagnostic algorithm for CHD patients. Materials and methods: CHD patients with persistent respiratory symptoms that were treated between January 2007 and December 2015 were retrospectively reviewed. The following data were recorded for all CHD patients with AC: age, cardiac anomalies, the compressed structure, the airway diameter ratio (ADR), the compressing structure(s), treatment, and follow-up.Results: During the …

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Comparison Of The Cardioprotective Effects Of Dexmedetomidineand Remifentanil In Cardiac Surgery, Medi̇ha Türktan, Yasemi̇n Güneş, Hafi̇ze Yaliniz, Selçuk Matyar, Zehra Hati̇poğlu, Ersel Güleç, Uğur Göçen, Atakan Atalay Jan 2017

Comparison Of The Cardioprotective Effects Of Dexmedetomidineand Remifentanil In Cardiac Surgery, Medi̇ha Türktan, Yasemi̇n Güneş, Hafi̇ze Yaliniz, Selçuk Matyar, Zehra Hati̇poğlu, Ersel Güleç, Uğur Göçen, Atakan Atalay

Turkish Journal of Medical Sciences

Background/aim: Myocardial protection is an important factor of open heart surgery and biological biomarkers (lactate, CKMB, cardiac troponin I, and pyruvate) are used to assess myocardial damage. This study compares the effects of dexmedetomidine and remifentanil on myocardial protection during coronary artery bypass grafting (CABG) surgery. Materials and methods: Patients scheduled for elective CABG surgery (n = 60) were included in this study. Anesthesia induction was introduced with propofol, fentanyl, and vecuronium bromide. Anesthesia was maintained with remifentanil infusion and sevoflurane in the remifentanil group (Group R) and with dexmedetomidine infusion and sevoflurane in the dexmedetomidine group (Group D). Blood …

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The Effects Of The Number Of Physical Therapy Sessions On Pain, Disability,And Quality Of Life In Patients With Chronic Low Back Pain, Burcu Meti̇n Ökmen, Engi̇n Koyuncu, Bi̇lal Uysal, Neşe Özgi̇rgi̇n Jan 2017

The Effects Of The Number Of Physical Therapy Sessions On Pain, Disability,And Quality Of Life In Patients With Chronic Low Back Pain, Burcu Meti̇n Ökmen, Engi̇n Koyuncu, Bi̇lal Uysal, Neşe Özgi̇rgi̇n

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to investigate and compare the effect of different physical therapy (PT) session numbers on pain, impairment. and quality of life in patients with chronic low back pain (LBP).Materials and methods: In this prospective, randomized-controlled, single-blind trial, a total of 60 patients with chronic LBP were divided into 2 groups with simple randomization within the scope of the study. A PT program of a total of 10 sessions was applied for patients in Group 10 (n = 30) and a total of 15 sessions for patients in Group 15 (n = 30). The main …

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Effect Of Treatment Of Iron Deficiency Anemia Onhemoglobin A1c In Type 2 Diabetic Patients, Ensieh Nasli-Esfahani, Bagher Larijani, Peyvand Amini, Robabeh Ghodsi Ghasemabadi, Rezvan Razmandeh Jan 2017

Effect Of Treatment Of Iron Deficiency Anemia Onhemoglobin A1c In Type 2 Diabetic Patients, Ensieh Nasli-Esfahani, Bagher Larijani, Peyvand Amini, Robabeh Ghodsi Ghasemabadi, Rezvan Razmandeh

Turkish Journal of Medical Sciences

Background/aim: Iron deficiency anemia (IDA) affects hemoglobin A1c (HbA1c) levels. This study aimed to evaluate the effect of treatment of iron deficiency anemia on hemoglobin A1c in type 2 diabetic patients.Materials and methods: Ninety type 2 diabetes mellitus (T2DM) patients with IDA were included in a randomized, placebo-controlled, single-blind clinical trial. The intervention group (n = 45) received 200 mg/day oral iron for 3 months and the control group (n = 45) received an oral placebo for the same period. Fasting blood sugar, complete blood count, and HbA1c were measured for all subjects at the beginning and the end of …

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Frequencies And Distributions Of Sex Chromosome Abnormalities In Females With The Turner Phenotype: A Long-Term Retrospective Study In The Southern Region Of Turkey, Ni̇lgün Tanriverdi̇, Osman Demi̇rhan, Di̇lara Süleymanova Karahan, Ayfer Pazarbaşi Jan 2017

Frequencies And Distributions Of Sex Chromosome Abnormalities In Females With The Turner Phenotype: A Long-Term Retrospective Study In The Southern Region Of Turkey, Ni̇lgün Tanriverdi̇, Osman Demi̇rhan, Di̇lara Süleymanova Karahan, Ayfer Pazarbaşi

Turkish Journal of Medical Sciences

Background/aim: The genetic background of Turner syndrome (TS) is highly variable. The correlation between genotype and phenotype is not yet well understood. The aim of this study was to describe the frequencies and distributions of Turner karyotypes and to discuss the phenotype/genotype relation in a very large group of individuals with TS. Materials and methods: The karyotype results of 248 female participants were evaluated retrospectively.Results: Of 248 females with the Turner phenotype, 14.5% had normal karyotypes and 85.5% had Turner karyotypes. About 72.2% of the abnormalities were numerical aberrations and 27.8% were structural aberrations. The most frequent karyotype was monosomy …

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Prevalence And Risk Factors For Helicobacter Pylori Infection In Southwest China: A Study Of Health Examination Participants Based On 13c-Urea Breath Test, Jie Liu, Yonghong Wang, Qinghua Zhao, Rong Luo, Mingzhao Xiao, Mingjun Zhang, Weibo Xie Jan 2017

Prevalence And Risk Factors For Helicobacter Pylori Infection In Southwest China: A Study Of Health Examination Participants Based On 13c-Urea Breath Test, Jie Liu, Yonghong Wang, Qinghua Zhao, Rong Luo, Mingzhao Xiao, Mingjun Zhang, Weibo Xie

Turkish Journal of Medical Sciences

Background/aim: Helicobacter pylori (H. pylori) has a high prevalence in developing countries. We aimed to investigate the current prevalence of H. pylori, as well as its potential serum risk factors, in a population from southwest China.Materials and methods: This cross-sectional study included 10,912 subjects who received medical examinations at the First Affiliated Hospital of Chongqing Medical University in 2014. Data regarding physical examinations and biochemical measurements were collected, and H. pylori infection was diagnosed with a 13C-urea breath test. Logistic regression was conducted to identify the risk factors for H. pylori infection.Results: The infection rate of H. pylori was 34.4% …

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Detection And Molecular Characterisation Of Adenovirus In Children Under 5 Years Old With Diarrhoea, Meryem Çolak, Gülendam Bozdayi, Ayli̇n Altay, Zahi̇de Yalaki̇, Kamruddi̇n Ahmed, Seçi̇l Özkan Jan 2017

Detection And Molecular Characterisation Of Adenovirus In Children Under 5 Years Old With Diarrhoea, Meryem Çolak, Gülendam Bozdayi, Ayli̇n Altay, Zahi̇de Yalaki̇, Kamruddi̇n Ahmed, Seçi̇l Özkan

Turkish Journal of Medical Sciences

Background/aim: To determine the frequency, genotype distribution, and genetic relatedness of adenoviruses in children under 5 years old with diarrhoea and to investigate their distribution according to clinical findings, age, months, and seasons. Materials and methods: Stool samples were collected from 180 children with acute gastroenteritis who presented from July 2007 through June 2011 at the Ankara Training and Education Hospital. Stool samples were analysed by immune chromatographic test (ICT), enzyme immunoassay (EIA), and polymerase chain reaction (PCR). All adenovirus types were determined by nucleotide sequence analysis. A phylogenetic tree was constructed by Mega 6.0 using the neighbour-joining method. Results: …

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Patients' Attitudes And Knowledge About Drug Use: A Survey In Turkish Family Healthcare Centres And State Hospitals, Ahmet Akici, Sali̇h Mollahali̇loğlu, Başak Dönertaş, Şenay Özgülcü, Ali̇ Alkan, Nesri̇n Fi̇li̇z Başaran Jan 2017

Patients' Attitudes And Knowledge About Drug Use: A Survey In Turkish Family Healthcare Centres And State Hospitals, Ahmet Akici, Sali̇h Mollahali̇loğlu, Başak Dönertaş, Şenay Özgülcü, Ali̇ Alkan, Nesri̇n Fi̇li̇z Başaran

Turkish Journal of Medical Sciences

Background/aim: Irrational drug use is a common problem. This study aimed to evaluate patients' knowledge and habits concerning drug use, and compare them in terms of some sociodemographic characteristics. Materials and methods: A face-to-face questionnaire was given to outpatients from family healthcare centres (FHCs) and state hospitals (SHs) in 12 provinces in Turkey during May 2010. A total of 4470 patients (FHCs: 2209; SHs: 2261) responded to the questionnaire (response rate: 93.1%). Results: Getting prescriptions without a physical examination was common (second place in FHCs; third place in SHs); 51.0% stated that they wanted physicians to prescribe drugs that they …

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Effects Of Whole Blood Viscosity And Plasma Nox On Cardiac Function And Cerebral Blood Flow In Children With Chronic Kidney Disease, Necla Buyan, Meltem Akçaboy, Tayfun Göktaş, Serdar Kula, Bi̇jen Nazliel, Ni̇lgün Çakar, Nermi̇n Uncu, Bülent Çeli̇k, Deni̇z Erbaş Jan 2017

Effects Of Whole Blood Viscosity And Plasma Nox On Cardiac Function And Cerebral Blood Flow In Children With Chronic Kidney Disease, Necla Buyan, Meltem Akçaboy, Tayfun Göktaş, Serdar Kula, Bi̇jen Nazliel, Ni̇lgün Çakar, Nermi̇n Uncu, Bülent Çeli̇k, Deni̇z Erbaş

Turkish Journal of Medical Sciences

Background/aim: The aim of the study was to investigate the effects of whole blood viscosity and plasma nitric oxide on cerebral and cardiovascular risks associated with chronic kidney disease. Materials and methods: The study group consisted of 40 pediatric patients and 21 healthy control subjects. Hematologic and biochemical variables, viscosity and plasma nitric oxide levels, echocardiographic findings, and middle cerebral artery blood flow velocity were examined. Results: Viscosity values of patients were significantly lower than those of the control group. Lower values of hematocrit, total protein, and albumin and higher values of ferritin in all patient groups resulted in significantly …

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Multiplex Pcr Detection Of Problematic Pathogens Of Clinically Heterogeneous Bacterial Vaginosis In Bulgarian Women, Konstantsa Tosheva-Daskalova, Tanya Vasileva Strateva, Ivan Gergov Mitov, Raina Tzvetanova Gergova Jan 2017

Multiplex Pcr Detection Of Problematic Pathogens Of Clinically Heterogeneous Bacterial Vaginosis In Bulgarian Women, Konstantsa Tosheva-Daskalova, Tanya Vasileva Strateva, Ivan Gergov Mitov, Raina Tzvetanova Gergova

Turkish Journal of Medical Sciences

Background/aim: This study aimed to investigate the correlation between the prevalence of problematic pathogens and the clinical status of women with bacterial vaginosis (BV). Materials and methods: Gardnerella vaginalis, Atopobium vaginae, and Mobiluncus spp. were detected using a multiplex PCR assay, and their role in the infection of Bulgarian women with clinically heterogeneous BV was evaluated. Results: The predominant BV-associated pathogen identified was G. vaginalis with an incidence of 98.39%, followed by A. vaginae (68.05%) and Mobiluncus spp. at 17.01%. The coexistence of A. vaginae and G. vaginalis was more common in women with discharge (in 72.04%) and in patients …

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Investigation Of Human Leukocyte Antigen In Osteoarticular Brucellosis, Sevi̇m Gönen, Murat Di̇zbay, Hüsnü Oğuz Söylemezoğlu Jan 2017

Investigation Of Human Leukocyte Antigen In Osteoarticular Brucellosis, Sevi̇m Gönen, Murat Di̇zbay, Hüsnü Oğuz Söylemezoğlu

Turkish Journal of Medical Sciences

Background/aim: To determine the relationship between human leukocyte antigen (HLA) antigens and osteoarticular brucellosis by evaluating HLA Class I and II antigens in control subjects and patients developing osteoarticular brucellosis in Turkey.Materials and methods: The study included 28 patients with osteoarticular involvement diagnosed with brucellosis and 100 controls. The HLA Class I and II antigens were studied in isolated DNA samples using sequence-specific oligonucleotide procedure.Results: The mean age of the 28 patients and 100 controls was 42.3 $\pm$ 20.2 years and 50.1 $\pm$ 16.3 years, respectively. When the frequency of HLA Class I was examined, HLA-A*02 and HLA-B*27 antigens were …

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Evaluation Of Pulmonary Vein Anatomy Using 256-Slice Computed Tomography, Yinghong Shi, Shaohua Mi, Yunxia Shi, Hongbo Wang, Jian Li, Benxia Yu, Fengli Liu, Heng Ma, Bin Wang Jan 2017

Evaluation Of Pulmonary Vein Anatomy Using 256-Slice Computed Tomography, Yinghong Shi, Shaohua Mi, Yunxia Shi, Hongbo Wang, Jian Li, Benxia Yu, Fengli Liu, Heng Ma, Bin Wang

Turkish Journal of Medical Sciences

Background/aim: This study aimed to evaluate pulmonary vein (PV) anatomy using 256-slice computed tomography (CT), which may be necessary for electrophysiologists to know before radiofrequency catheter ablation (RFCA) therapy.Materials and methods: A total of 102 patients with paroxysmal and persistent atrial fibrillation underwent 256-slice cardiac CT angiography prior to catheter ablation. PV morphology, ostial diameter, ostial orientation, and distance from ostium to first bifurcation were evaluated using three-dimensional volume-rendering and multiplanar-reformatting technology. Results: We found that 72.5% of patients had four conventional PVs. On the right, 22.5% of patients had one accessory PV, 4.9% had 2 accessory PVs, 1% had …

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Analysis Of Recurrent Urethral Strictures Due To Iatrogenic Urethral Trauma, Fuat Kizilay, Adnan Şi̇mşi̇r, Mehmet Ceyhun Özyurt Jan 2017

Analysis Of Recurrent Urethral Strictures Due To Iatrogenic Urethral Trauma, Fuat Kizilay, Adnan Şi̇mşi̇r, Mehmet Ceyhun Özyurt

Turkish Journal of Medical Sciences

Background/aim: We aimed to analyze the effects of stricture location, etiology, age, and catheterization time on recurrence rate and recurrence time in patients who underwent direct vision internal urethrotomy (DVIU) for urethral strictures. Materials and methods: Patients were divided into three groups according to the location of the stricture: penile urethra, membranous urethra, and prostatic urethra strictures. Patients were also divided into three groups according to etiologic factors: strictures secondary to endoscopic procedures, urethral catheterization, and open or radical prostatectomy (anastomotic strictures were included in this group). Patients were also divided into three groups according to catheterization time: 5-7 days. …

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Epidemiology And Analysis Of Invasive Fungal Infections In Patients Withhematological Malignancies: A Single-Center Real-Life Experience, Nur Soyer, Hati̇ce Demet Ki̇per Ünal, Fi̇li̇z Vural, Fahri̇ Şahi̇n, Mahmut Töbü, Ayhan Dönmez, Murat Tombuloğlu, Bi̇lgi̇n Arda, Güray Saydam Jan 2017

Epidemiology And Analysis Of Invasive Fungal Infections In Patients Withhematological Malignancies: A Single-Center Real-Life Experience, Nur Soyer, Hati̇ce Demet Ki̇per Ünal, Fi̇li̇z Vural, Fahri̇ Şahi̇n, Mahmut Töbü, Ayhan Dönmez, Murat Tombuloğlu, Bi̇lgi̇n Arda, Güray Saydam

Turkish Journal of Medical Sciences

Background/aim: Invasive fungal infection (IFI) causes morbidity and mortality among patients with hematological malignancies. We evaluated the incidence and treatment characteristics of IFIs between October 2012 and December 2013. Materials and methods: Patients who received chemotherapy or stem cell transplantation were retrospectively evaluated. Fungal infections were classified according to EORTC criteria.Results: Prophylaxis and antifungal therapy were given in 30.5% and 23.6% of 522 chemotherapy courses, respectively. The incidence of proven/probable IFI was 6.7%. The incidence of IFI among patients who received prophylaxis was significantly higher than among those who did not receive it (11.3% vs. 4.6%, P = 0.005). There …

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The Relationship Between The Degree Of Skin Fibrosis By Sonoelastography And The Degree Of Pulmonary Involvement In Scleroderma, Songül Çi̇ldağ, Mehmet Burak Çi̇ldağ Jan 2017

The Relationship Between The Degree Of Skin Fibrosis By Sonoelastography And The Degree Of Pulmonary Involvement In Scleroderma, Songül Çi̇ldağ, Mehmet Burak Çi̇ldağ

Turkish Journal of Medical Sciences

Background/aim: This study aimed to assess the relationship between skin fibrosis as determined by sonoelastography and the degree of pulmonary involvement as determined by high-resolution computed tomography (HRCT) in patients with diffuse cutaneous systemic sclerosis (dcSSc).Materials and methods: This prospective study included 40 patients with dcSSc. All patients with HRCT scans underwent conventional ultrasonography and sonoelastography to determine skin thickness and degree of fibrosis. The degree of fibrosis was classified according to color-scale sonoelastography. The degree of pulmonary involvement was classified according to HRCT grading groups. The relationship between skin fibrosis and pulmonary involvement was investigated.Results: There was a statistically …

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Comparison Of Tidal Volume And Deep Breath Preoxygenation Techniquesundergoing Coronary Artery Bypass Graft Surgery: Effects Of Hemodynamicresponse And Arterial Oxygenation*, Zafer Taş, Tülay Hoşten, Alparslan Kuş, Sevi̇m Cesur, Neşe Türkyilmaz, Ahmet Arikan, Zeynep Mi̇ne Solak Jan 2017

Comparison Of Tidal Volume And Deep Breath Preoxygenation Techniquesundergoing Coronary Artery Bypass Graft Surgery: Effects Of Hemodynamicresponse And Arterial Oxygenation*, Zafer Taş, Tülay Hoşten, Alparslan Kuş, Sevi̇m Cesur, Neşe Türkyilmaz, Ahmet Arikan, Zeynep Mi̇ne Solak

Turkish Journal of Medical Sciences

Background/aim: Different techniques exist for the preoxygenation of patients that will be operated on under general anesthesia. Preoxygenation with the deep breath (DB) method may affect cardiovascular stability, which is crucial for coronary artery bypass graft (CABG) patients. In this study, we aimed to compare the effects of the 3 min TVB preoxygenation technique and 1 min 8DBs technique on hemodynamic response and arterial oxygenation in patients with normal ejection fraction that were scheduled for elective CABG surgery. Materials and methods: Forty patients classified as ASA II?III and scheduled for elective CABG surgery were randomly assigned to TVB/3 min or …

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Genotype Distribution Of Mycobacterium Tuberculosis In Theaegean Region And Associated Demographic Factors, Cengi̇z Çavuşoğlu, Fethi̇ye Ferda Yilmaz, İsabel Rai̇ka Durusoy Onmuş, Tuğba Bozdemi̇r, Hüseyi̇n Taşli, Mi̇ne Hoşgör Li̇moncu Jan 2017

Genotype Distribution Of Mycobacterium Tuberculosis In Theaegean Region And Associated Demographic Factors, Cengi̇z Çavuşoğlu, Fethi̇ye Ferda Yilmaz, İsabel Rai̇ka Durusoy Onmuş, Tuğba Bozdemi̇r, Hüseyi̇n Taşli, Mi̇ne Hoşgör Li̇moncu

Turkish Journal of Medical Sciences

Background/aim: The Aegean Region is the second-ranking region in Turkey according to the Human Development Index and population density and it hosts 1/8 of Turkey's population. İzmir is the largest city of the region, receiving internal migration both from inside and outside the region. The tuberculosis incidence in İzmir is lower than overall in Turkey: 17.7/100,000 in 2011. Our aims were to determine genotypes of Mycobacterium tuberculosis isolates; to explore possible associations between genotypes with case-demographic data, clinical presentation, and antimicrobial susceptibility patterns; and to determine variations in genotype distribution of strains isolated in Ege University Hospital, İzmir. Materials and …

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Efficacy Of Bispectral Index Monitoring For Prevention Of Anestheticawareness And Complications During Oocyte Pick-Up Procedure, Aykut Urfalioğlu, Mahmut Arslan, Süleyman Murat Bakacak, Hafi̇ze Öksüz, Ömer Faruk Boran, Gözen Öksüz Jan 2017

Efficacy Of Bispectral Index Monitoring For Prevention Of Anestheticawareness And Complications During Oocyte Pick-Up Procedure, Aykut Urfalioğlu, Mahmut Arslan, Süleyman Murat Bakacak, Hafi̇ze Öksüz, Ömer Faruk Boran, Gözen Öksüz

Turkish Journal of Medical Sciences

Background/aim: This study was planned by considering that the use of bispectral index (BIS) monitoring ensures sufficient depth of anesthesia and avoids anesthetic awareness and patient movement in the oocyte pick-up (OPU) procedure.Materials and methods: Ninety-eight patients undergoing OPU were randomly divided into 2 groups as the control group (n = 48) and BIS group (n = 50). After propofol and remifentanil induction, the control group was given additional propofol according to reaction response, while the BIS group was given propofol at BIS values of 60 and above with the aim that BIS values be 40?60. Total procedure time, recovery …

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The Histopathological And Stereological Assessment Of The Effect Of Topically Administered Leptin On Cerebral Vasospasm In An Experimental Subarachnoid Hemorrhage Model, Cem Demi̇rel, Cengi̇z Çokluk, Abdurrahman Aksoy, Kerameddi̇n Aydin, Mehmet Emi̇n Önger, Eni̇s Kuruoğlu, Abdullah Hi̇lmi̇ Marangoz, Ömür Gülsüm Deni̇z, Süleyman Kaplan Jan 2017

The Histopathological And Stereological Assessment Of The Effect Of Topically Administered Leptin On Cerebral Vasospasm In An Experimental Subarachnoid Hemorrhage Model, Cem Demi̇rel, Cengi̇z Çokluk, Abdurrahman Aksoy, Kerameddi̇n Aydin, Mehmet Emi̇n Önger, Eni̇s Kuruoğlu, Abdullah Hi̇lmi̇ Marangoz, Ömür Gülsüm Deni̇z, Süleyman Kaplan

Turkish Journal of Medical Sciences

Background/aim: Cerebral vasospasm is a term that refers to prolonged, slowly progressing but reversible pathological narrowing of cerebral arteries occurring several days after subarachnoid hemorrhage (SAH), usually accompanied by a decrease in perfusion distal to the affected artery. Leptin is an endogenous polypeptide hormone that can be carried freely and bound to protein in the blood. Materials and methods: We investigated the superiority of topical application of leptin that may make a contribution to the development of new treatment modalities for unconscious patients in brain injury intensive care units and its preventive effect, which is considered to have multifactorial pathogenesis …

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Combined Oral Supplementation Of Chromium Picolinate, Docosahexaenoic Acid, And Boron Enhances Neuroprotection In Rats Fed A High-Fat Diet, Cemal Orhan, Nurhan Şahi̇n, Zeynep Tuzcu, James R. Komorowski, Kazi̇m Şahi̇n Jan 2017

Combined Oral Supplementation Of Chromium Picolinate, Docosahexaenoic Acid, And Boron Enhances Neuroprotection In Rats Fed A High-Fat Diet, Cemal Orhan, Nurhan Şahi̇n, Zeynep Tuzcu, James R. Komorowski, Kazi̇m Şahi̇n

Turkish Journal of Medical Sciences

Background/aim: A novel complex of a nutritional supplement (CDB) contains chromium picolinate (CrPic), phosphatidylserine (PS), docosahexaenoic acid (DHA), and boron (B). The present study aimed to investigate the effects of CDB on the metabolic profile and memory acquisition in rats fed a high-fat diet (HFD). Materials and methods: Male Wistar rats were divided into six groups and received either a regular diet or HFD supplemented with or without different levels of CDB (0, 11, or 22 mg/kg BW). Results: Rats fed the HFD had greater glucose, insulin, lipid profile, and serum malondialdehyde concentrations, but lower serotonin and tryptophan in the …

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The Effects Of Mesenchymal Stem Cells On The Structure And Contractile Force Of The Carotid Artery In A Rat Aneurysm Model, Özbeyen Atalay, Handan Sevi̇m, Seçi̇l Karahi̇sar Turan, Mehmet Ali̇ Onur, Özer Ayli̇n Gürpinar Jan 2017

The Effects Of Mesenchymal Stem Cells On The Structure And Contractile Force Of The Carotid Artery In A Rat Aneurysm Model, Özbeyen Atalay, Handan Sevi̇m, Seçi̇l Karahi̇sar Turan, Mehmet Ali̇ Onur, Özer Ayli̇n Gürpinar

Turkish Journal of Medical Sciences

Background/aim: An aneurysm is a pathological enlargement of an artery characterized by the thinning of the elastic fiber layer in the tunica media. Because the aneuritic artery wall is weakened, these vessels can rupture and cause serious bleeding. Surgical methods are often used for the treatment of aneurysms. However, cell-based therapies are less invasive and potentially safer alternatives. In this study, the therapeutic efficacy of rat adipose tissue-derived mesenchymal stem cells (MSCs) was investigated in a new carotid artery aneurysm model.Materials and methods: Arteries were pretreated with elastase to create aneurysms. Gelatin matrices containing MSCs were applied to the outer …

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Exogenous Erythropoietin Aggravates Retinal Neovascularizationin A Murine Model Of Proliferative Retinopathy, Ning Yang, Wenxi Zhang, Tao He, Yiqiao Xing Jan 2017

Exogenous Erythropoietin Aggravates Retinal Neovascularizationin A Murine Model Of Proliferative Retinopathy, Ning Yang, Wenxi Zhang, Tao He, Yiqiao Xing

Turkish Journal of Medical Sciences

Background/aim: Erythropoietin (EPO) has been proven recently to be a critical mediator in retinal neovascularization (RNV). Previous studies have indicated that the use of recombinant human EPO (rEPO) is a high risk factor in the development of retinopathy of prematurity. In this study, we aimed to investigate the effect of rEPO administration on RNV and its underlying mechanism in a mouse model of oxygen-induced retinopathy (OIR). Materials and methods: A murine model of OIR was used to generate RNV. After daily intraperitoneal injection of rEPO from postnatal day 12 (P12), mice were euthanized at P17. Whole-mount retina staining was used …

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Effects Of Valproic Acid On Sympathetic Activity And Left Ventricularmyocardial Remodelling In Rats During Pressure Overload, Yang Liu, Siyu Li, Zhigang Zhang, Zhanjun Lv, Huijie Jiang, Xiao Tan, Fengquan Liu Jan 2017

Effects Of Valproic Acid On Sympathetic Activity And Left Ventricularmyocardial Remodelling In Rats During Pressure Overload, Yang Liu, Siyu Li, Zhigang Zhang, Zhanjun Lv, Huijie Jiang, Xiao Tan, Fengquan Liu

Turkish Journal of Medical Sciences

Background/aim: Pressure overload induces cardiac remodelling and results in heart failure. Enhanced sympathetic outflow participates in the development of cardiac remodelling for the duration of pressure overload as an independent factor. Valproic acid has recently been shown to reduce neuronal injury and have antiinflammatory and antiapoptotic effects as a histone deacetylase inhibitor. We speculate that the drug plays a specific role in alleviating cardiac remodelling by inhibiting sympathetic activity. Materials and methods: Surgery of partial abdominal aortic constriction was performed on male Sprague-Dawley rats. After 4 weeks, animal models of pressure overload were validated and then valproic acid (300 mg/kg) …

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