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2017

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Articles 11461 - 11490 of 14524

Full-Text Articles in Medicine and Health Sciences

Abdominal Actinomycosis In The Last 10 Years And Risk Factors For Appendiceal Actinomycosis: Review Of The Literature, Marta Lisa-Gracia, Berta Martín-Rivas, Marcos Pajaron-Guerrero, Ana Arnaiz-García Jan 2017

Abdominal Actinomycosis In The Last 10 Years And Risk Factors For Appendiceal Actinomycosis: Review Of The Literature, Marta Lisa-Gracia, Berta Martín-Rivas, Marcos Pajaron-Guerrero, Ana Arnaiz-García

Turkish Journal of Medical Sciences

Background/aim: Actinomycosis is a granulomatous disease caused by filamentous, gram-positive, anaerobic bacteria. Actinomycetes are commensal inhabitants of the oral cavity and intestinal tract but acquire pathogenicity through invasion of breached or necrotic tissue. In abdominal actinomycosis (AA), the appendix and ileocecal region are usually involved. The aim of this study was to characterize patients diagnosed with AA and to establish the risk factors for appendiceal actinomycosis, including a short review of the literature. Materials and methods: We conducted a prospective cohort study of all patients diagnosed with AA in the University Hospital Marques de Valdecilla (Santander-Cantabria) from January 2003 to …

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Nitric Oxide In Cerebrospinal Fluid Of Central Nervous System Tuberculosis: Correlations With Culture, Antibody Response, And Cell Count, Kavitha Kumar, Prashant Giribhattanavar, Shripad Patil Jan 2017

Nitric Oxide In Cerebrospinal Fluid Of Central Nervous System Tuberculosis: Correlations With Culture, Antibody Response, And Cell Count, Kavitha Kumar, Prashant Giribhattanavar, Shripad Patil

Turkish Journal of Medical Sciences

Background/aim: The role of nitric oxide (NO) has been established in infection over the years. NO functions by inhibiting the growth of intracellular pathogens. The present study was undertaken to ascertain the role of NO in central nervous system (CNS) infection by Mycobacterium tuberculosis. Materials and methods: A total of 781 chronic meningitis cerebrospinal fluid (CSF) samples suspected of CNS tuberculosis (TB) were categorized based on M. tuberculosis culture positivity, anti-TB antibody response, and CSF cell count and were analyzed for NO. Results: We found that NO levels were positive in 10.88% of the CSF samples. Positivity for NO was …

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Endometriosis-Associated Changes In Serum Levels Of Interferons And Chemokines, Andrei Mihai Malutan, Tudor Drugan, Razvan Ciortea, Carmen Bucuri, Maria Patricia Rada, Dan Mihu Jan 2017

Endometriosis-Associated Changes In Serum Levels Of Interferons And Chemokines, Andrei Mihai Malutan, Tudor Drugan, Razvan Ciortea, Carmen Bucuri, Maria Patricia Rada, Dan Mihu

Turkish Journal of Medical Sciences

Background/aim: The aim of the study was to evaluate the serum concentration of main chemokines and interferons in patients with diagnosed endometriosis. Materials and methods: A total of 160 women were divided in two study groups (group 1 - endometriosis; group 2 - healthy women). Serum levels of IFN-α, IFN-γ, MCP-1, MIP-1α, MIP-1β, RANTES, eotaxin, IL-8, MIG, IP-10, and IL-17A were measured with Human Multiplex Cytokine Panels. Results. Serum levels of IFN-γ, MCP-1, and IL-8 were significantly higher (mean 14.03, 57.24, and 534.24, respectively, compared to 0.58, 20.51, and 259.82, respectively), and serum levels of IP-10 and eotaxin were significantly …

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Qf-Pcr In Invasive Prenatal Diagnosis: A Single-Center Experience In Turkey, Özge Özer Kaya, Altuğ Koç, Taha Reşi̇d Özdemi̇r, Özgür Kirbiyik, Berk Özyilmaz, Mehmet Özeren, Deni̇z Can Özteki̇n, Cüneyt Eftal Taner, Yaşar Beki̇r Kutbay Jan 2017

Qf-Pcr In Invasive Prenatal Diagnosis: A Single-Center Experience In Turkey, Özge Özer Kaya, Altuğ Koç, Taha Reşi̇d Özdemi̇r, Özgür Kirbiyik, Berk Özyilmaz, Mehmet Özeren, Deni̇z Can Özteki̇n, Cüneyt Eftal Taner, Yaşar Beki̇r Kutbay

Turkish Journal of Medical Sciences

Background/aim: QF-PCR has been used for more than 20 years. It is based on investigation of polymorphic short tandem repeats (STRs) and is widely used for prenatal rapid aneuploidy detection. Materials and methods: We report retrospectively our prenatal diagnosis results between January 2012 and May 2014 in Tepecik Training and Research Hospital Genetic Diagnostic Center. Prenatal diagnosis was recommended in 6800 high-risk pregnancies and 2883 patients agreed to invasive diagnosis. Chromosome analysis and QF-PCR were performed in all patients. Results: Normal results were reported in 2711 cases by fetal karyotyping and in 2706 cases by QF-PCR. Anomaly detection rates were …

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Using Fuzzy Logic For Diagnosis And Classification Of Spasticity, Veysel Alcan, Mehmet Rahmi̇ Canal, Murat Zi̇nnuroğlu Jan 2017

Using Fuzzy Logic For Diagnosis And Classification Of Spasticity, Veysel Alcan, Mehmet Rahmi̇ Canal, Murat Zi̇nnuroğlu

Turkish Journal of Medical Sciences

Background/aim: Spasticity is generally defined as a sensory-motor control disorder. However, there is no pathophysiological mechanism or appropriate measurement and evaluation standards that can explain all aspects of a possible spasticity occurrence. The objective of this study is to develop a fuzzy logic classifier (FLC) diagnosis system, in which a quantitative evaluation is performed by surface electromyography (EMG), and investigate underlying pathophysiological mechanisms of spasticity. Materials and methods: Surface EMG signals recorded from the tibialis anterior and medial gastrocnemius muscles of hemiplegic patients with spasticity and a healthy control group were analyzed in standing, resting, dorsal flexion, and plantar flexion …

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Comparison Of Response To Treatment Of Unilateral And Bilateral Varicocelectomy, Ercan Öğreden, Ural Oğuz, Abdullah Çirakoğlu, Erhan Demi̇relli̇, Erdal Benli̇, Orhan Yalçin Jan 2017

Comparison Of Response To Treatment Of Unilateral And Bilateral Varicocelectomy, Ercan Öğreden, Ural Oğuz, Abdullah Çirakoğlu, Erhan Demi̇relli̇, Erdal Benli̇, Orhan Yalçin

Turkish Journal of Medical Sciences

Background/aim: We aimed to compare the results of unilateral and bilateral varicocele surgery. Materials and methods: In two referral hospitals, the data of 180 patients who were treated with unilateral and bilateral microscopic varicocelectomy were retrospectively analyzed. Sperm parameters and spontaneous pregnancy rates were compared in patients who underwent bilateral and unilateral microscopic varicocelectomy. Results: The mean age was 29.6 (17-46) years. While 82 patients underwent unilateral varicocelectomy (Group I), 98 patients underwent bilaterally varicocelectomy (Group II). Forty (48.8%) spontaneous pregnancies occurred in Group I and 59 (60.2%) in Group II. When we analyzed sperm parameters, the rate of increase …

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The Prevalence Of Coronary Artery Anomalies With Coronary Computed Tomography, Hakki Yeşi̇lyurt, Uğur Aksu, Kamuran Kalkan, Seli̇m Topcu, Enbi̇ya Aksakal, İbrahi̇m Hali̇l Tanboğa, Recep Sade, Fati̇h Rifat Ulusoy, Abdulmeci̇t Kantarci Jan 2017

The Prevalence Of Coronary Artery Anomalies With Coronary Computed Tomography, Hakki Yeşi̇lyurt, Uğur Aksu, Kamuran Kalkan, Seli̇m Topcu, Enbi̇ya Aksakal, İbrahi̇m Hali̇l Tanboğa, Recep Sade, Fati̇h Rifat Ulusoy, Abdulmeci̇t Kantarci

Turkish Journal of Medical Sciences

Background/aim: In this study, the aim is to investigate the prevalence of various coronary artery anomalies (CAAs), evaluated by 256-detector row coronary computed tomography (CCT), within the Turkish population. Materials and methods: We included 2973 patients who had received CCT. The high take-off right coronary artery (RCA) and left coronary artery (LCA), the RCA arising from the left sinus (LS), the LCA arising from the right sinus (RS), the circumflex artery (CX) arising from the RS, the single coronary ostium originating from the RS, the CX arising from the RCA, and the RCA arising from the pulmonary artery were evaluated. …

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Retrospective Analysis Of Primary Gastric Diffuse Largeb-Cell Lymphoma: A Single Center Study From Turkey, Nur Soyer, Asu Fergün Yilmaz, Nazan Özsan, Fahri̇ Şahi̇n, Güray Saydam, Murat Tombuloğlu, Mi̇ne Heki̇mgi̇l, Fi̇li̇z Vural Jan 2017

Retrospective Analysis Of Primary Gastric Diffuse Largeb-Cell Lymphoma: A Single Center Study From Turkey, Nur Soyer, Asu Fergün Yilmaz, Nazan Özsan, Fahri̇ Şahi̇n, Güray Saydam, Murat Tombuloğlu, Mi̇ne Heki̇mgi̇l, Fi̇li̇z Vural

Turkish Journal of Medical Sciences

Background/aim: Diffuse large B-cell primary gastric lymphomas (DLBC-PGLs) are treated with different therapies. Their optimal treatment is not well documented. Materials and methods: We retrospectively analyzed the data of 51 patients diagnosed with DLBC-PGL in the previous 10 years. All patients were treated with R-CHOP as first line. Radiotherapy was added to chemotherapy in 8 patients. Surgery was performed in 5 patients. Results: The median follow-up time of the 51 patients was 45.5 (range 5-144) months and the complete response (CR) rate was 90.2%. CR was achieved in 34 (89.4%) of 38 patients treated with single chemotherapy, in all (100%) …

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Evaluation Of Dental Technician's Pneumoconiosis Using Chest X-Rayand Hrct: Correlation Between Radiological And Functional Findings, Recai̇ Ergün, Di̇lek Ergün, Ender Evci̇k, Begüm Ergan Jan 2017

Evaluation Of Dental Technician's Pneumoconiosis Using Chest X-Rayand Hrct: Correlation Between Radiological And Functional Findings, Recai̇ Ergün, Di̇lek Ergün, Ender Evci̇k, Begüm Ergan

Turkish Journal of Medical Sciences

Background/aim: This study aimed to compare high-resolution computed tomography (HRCT) findings with those of chest X-ray (CXR) and to evaluate the relationship of pulmonary function test (PFT) parameters with HRCT and CXR findings in cases of dental technician's pneumoconiosis. Materials and methods: CXR, PFT, and HRCT data of 89 dental technicians who were diagnosed with pneumoconiosis were retrospectively evaluated. Results: The cases of 24 dental technicians (27%) classified as normal (Category 0) based on CXR were evaluated as Category 1 according to HRCT. There was an inverse correlation of PFT parameters with nodular profusion score in CXR and all HRCT …

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A Descriptive Study Of Adherence To Lifestyle Modificationfactors Among Hypertensive Patients, Fadwa Alhalaiqa, Ahmad Al-Nawafleh, Abdul-Monim Batiha, Rami Masa'deh, Aida Abd Al-Razek Jan 2017

A Descriptive Study Of Adherence To Lifestyle Modificationfactors Among Hypertensive Patients, Fadwa Alhalaiqa, Ahmad Al-Nawafleh, Abdul-Monim Batiha, Rami Masa'deh, Aida Abd Al-Razek

Turkish Journal of Medical Sciences

Background/aim: Healthy life style recommendations (e.g., physical activity, healthy diet, and decreased cholesterol levels) play an important role in controlling blood pressure (BP). This study aimed to assess lifestyle modification factors among patients diagnosed with hypertension. Materials and methods: A descriptive-survey design was used. Data were collected using four questionnaires; one was the Beliefs about Medication questionnaire (BMQ) and the rest were developed to collect data about demographic and clinical characteristics and lifestyle modification factors. Results: In total 312 questionnaires were completed. The results revealed that our participants did not follow the healthy lifestyle recommendations; for example, the mean blood …

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Can Ischemia-Modified Albumin Be Used To Differentiate Between Generalized Seizures And Pseudoseizures?, Tülay Kamaşak, Süleyman Türedi̇, Hepsen Mi̇ne Seri̇n, Ahmet Menteşe, Abdülkadi̇r Gündüz, Ahmet Alver, Ali̇ Cansu Jan 2017

Can Ischemia-Modified Albumin Be Used To Differentiate Between Generalized Seizures And Pseudoseizures?, Tülay Kamaşak, Süleyman Türedi̇, Hepsen Mi̇ne Seri̇n, Ahmet Menteşe, Abdülkadi̇r Gündüz, Ahmet Alver, Ali̇ Cansu

Turkish Journal of Medical Sciences

Background/aim: In recent years ischemia-modified albumin (IMA) has been suggested as a marker that can be used in differentiating nonconvulsive conditions from epilepsy. The purpose of this study was to investigate changes in IMA levels caused by generalized clonic tonic (GTC) seizures. Materials and methods: A total of 114 children presenting to the Karadeniz Technical Pediatric Emergency Polyclinic with GTC seizures were included in the study. Sixteen cases meeting the inclusion criteria were included in the study and sixteen healthy children were enrolled as the control group. The patients' IMA, albumin, and IMA/albumin values at hours 0 and 1 following …

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Pentoxifylline Attenuates Mucosal Damage In An Experimental Model Of Rat Colitis By Modulating Tissue Biomarkers Of Inflammation, Oxidative Stress, And Fibrosis, Eylem Karatay, Özlem Gül Utku, Harun Erdal, Mehmet Arhan, İbrahi̇m Koral Önal, Mehmet İbi̇ş, Özgür Eki̇nci̇, Canan Yilmaz Demi̇rtaş, Gi̇yaseddi̇n Şükrü Dumlu Jan 2017

Pentoxifylline Attenuates Mucosal Damage In An Experimental Model Of Rat Colitis By Modulating Tissue Biomarkers Of Inflammation, Oxidative Stress, And Fibrosis, Eylem Karatay, Özlem Gül Utku, Harun Erdal, Mehmet Arhan, İbrahi̇m Koral Önal, Mehmet İbi̇ş, Özgür Eki̇nci̇, Canan Yilmaz Demi̇rtaş, Gi̇yaseddi̇n Şükrü Dumlu

Turkish Journal of Medical Sciences

Background/aim: This study was designed to identify the effect of pentoxifylline on trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats. Materials and methods: Forty-two female Wistar rats were randomly divided into 7 groups: group A, TNBS + intraperitoneal (IP) pentoxifylline; group B, TNBS + IP saline; group C, TNBS + intrarectal (IR) pentoxifylline; group D, TNBS + IR saline; group E, IP pentoxifylline + TNBS; group F, IP saline + TNBS; group G, IR saline. Pentoxifylline was given daily for 3 days before or 6 days after the induction of colitis. Rats were killed after 6 days. Results: IP and IR …

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Effects Of Coadministration Of Artemisinin And Iron On Histopathologicalalterations In The Ags Gastric Adenocarcinoma Cell Line, Payman Zare, Amir Ali Shahbazfar, Mahsa Alem, Salman Varmaghani, Ali Ebrahimi Katouli, Aliasghar Parvaresh Anbar, Pouria Bahrami Jan 2017

Effects Of Coadministration Of Artemisinin And Iron On Histopathologicalalterations In The Ags Gastric Adenocarcinoma Cell Line, Payman Zare, Amir Ali Shahbazfar, Mahsa Alem, Salman Varmaghani, Ali Ebrahimi Katouli, Aliasghar Parvaresh Anbar, Pouria Bahrami

Turkish Journal of Medical Sciences

Background/aim: The aim of the present study was to examine the anticancer effects of combination treatment with artemisinin and iron on the human gastric cancer cell line. Materials and methods: The AGS cell line was cultivated separately as a monolayer in culture flasks and different doses of 99% pure artemisinin with invariable doses of iron sulfate were added to the culture media and adhesive cells on the flask's bottom were stained with hematoxylin-eosin for a pathological assay. Results: Damage to cancerous cells increased dose dependently and it was higher in the combination treatment groups (artemisinin plus iron). The histopathological changes …

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Endosonogragphic Features Of Lesions Suggesting Gastricectopic Pancreas: Experience Of A Single Tertiary Center, Mahmut Yüksel, Sabi̇te Kacar, Muhammet Yener Akpinar, Fati̇h Saygili, Meral Akdoğan Kayhan, Selçuk Di̇şi̇beyaz, Yasemi̇n Özi̇n, Mustafa Kaplan, İhsan Ateş, Ertuğrul Kayaçeti̇n Jan 2017

Endosonogragphic Features Of Lesions Suggesting Gastricectopic Pancreas: Experience Of A Single Tertiary Center, Mahmut Yüksel, Sabi̇te Kacar, Muhammet Yener Akpinar, Fati̇h Saygili, Meral Akdoğan Kayhan, Selçuk Di̇şi̇beyaz, Yasemi̇n Özi̇n, Mustafa Kaplan, İhsan Ateş, Ertuğrul Kayaçeti̇n

Turkish Journal of Medical Sciences

Background/aim: We aimed to present the endoscopic ultrasound (EUS) features of gastric lesions suggesting gastric ectopic pancreas during upper gastrointestinal endoscopy that were diagnosed in our gastroenterology unit, which is a tertiary center for endoscopic procedures in Turkey. Materials and methods: The data of patients who underwent upper gastrointestinal EUS in our center between April 2012 and July 2014 were retrospectively analyzed. Results: All of the lesions suggesting gastric ectopic pancreas were localized in the gastric antrum. Thirty-six of 44 lesions (81.1%) showed central dimpling. Lesion borders were shown to be definite in 10 (22.7%) lesions, whereas the borders of …

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Analysis Of Meiotic Spindle And Zona Pellucida Birefringenceof Ivm Oocytes In Pcos Patients, Fereshteh Safian, Mohammad Ali Khalili, Sareh Ashourzadeh, Marjan Omidi Jan 2017

Analysis Of Meiotic Spindle And Zona Pellucida Birefringenceof Ivm Oocytes In Pcos Patients, Fereshteh Safian, Mohammad Ali Khalili, Sareh Ashourzadeh, Marjan Omidi

Turkish Journal of Medical Sciences

Background/aim: Polycystic ovarian syndrome (PCOS) is one of the most common causes of infertility. One of the best therapeutic options for PCOS patients is intracytoplasmic sperm injection (ICSI). In vitro maturation (IVM) can also be a useful technique for these women. The goal of this study was to evaluate both the zona pellucida (ZP) birefringence and meiotic spindle (MS) of in vivo- and in vitro-matured oocytes from PCOS patients using the PolScope system. Materials and methods: Immature oocytes undergoing IVM and MII oocytes were obtained from PCOS patients in an ICSI program. Using PolScope, the presence of MS and ZP …

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The Efficacy Of Narrowband Uvb Treatment In Pediatricvitiligo: A Retrospective Analysis Of 26 Cases, Serkan Yazi̇ci̇, Berri̇n Günay, Emel Bülbül Başkan, Kenan Aydoğan, Hayri̇ye Saricaoğlu, Şükran Tunali Jan 2017

The Efficacy Of Narrowband Uvb Treatment In Pediatricvitiligo: A Retrospective Analysis Of 26 Cases, Serkan Yazi̇ci̇, Berri̇n Günay, Emel Bülbül Başkan, Kenan Aydoğan, Hayri̇ye Saricaoğlu, Şükran Tunali

Turkish Journal of Medical Sciences

Background/aim: Narrowband UVB (Nb UVB) treatment is commonly used for the management of psoriasis and atopic dermatitis, and is less often used for vitiligo in children. The aim of this study was to evaluate the efficacy and short-term safety of Nb UVB phototherapy in children diagnosed with vitiligo retrospectively Materials and methods: A total of 26 patients younger than 18 years with the diagnosis of vitiligo and managed with Nb UVB phototherapy as documented in archive records were evaluated. Clinical response was assessed according to repigmentation of the lesions: good response when there was more than 75% repigmentation, moderate response …

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A Review Of Pediatric Pulmonary Hypertension With New Guidelines, Serdar Kula, Ayhan Pektaş Jan 2017

A Review Of Pediatric Pulmonary Hypertension With New Guidelines, Serdar Kula, Ayhan Pektaş

Turkish Journal of Medical Sciences

This study aims to review pediatric pulmonary hypertension (PH) by comparing the guidelines of the European Society of Cardiology (ESC)/European Respiratory Society (ERS), the American Heart Association (AHA)/American Thoracic Society (ATS), and the European Pediatric Pulmonary Vascular Disease Network (EPPVDN). All three sets of guidelines define PH as having a mean pulmonary artery pressure of ≥25 mmHg and accept the validity of the World Health Organization (WHO) classification system. Every child with a high index of suspicion for PH should undergo an initial work-up of chest X-rays, electrocardiography, and echocardiography. The AHA/ATS guidelines emphasize the necessity of cardiac catheterization and …

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Alpha-1 Antitrypsin Levels And Polymorphisms In Interstitial Lung Diseases, Nalan Demi̇r, Özlem Erçen Di̇ken, Hali̇l Gürhan Karabulut, Demet Karnak, Oya Kayacan Jan 2017

Alpha-1 Antitrypsin Levels And Polymorphisms In Interstitial Lung Diseases, Nalan Demi̇r, Özlem Erçen Di̇ken, Hali̇l Gürhan Karabulut, Demet Karnak, Oya Kayacan

Turkish Journal of Medical Sciences

Background/aim: Alpha-1 antitrypsin deficiency may be a potential predisposing factor for interstitial lung fibrosis. We investigated alpha-1 antitrypsin levels and its polymorphisms in patients with interstitial lung disease. Materials and methods: A total of 103 interstitial lung disease patients were compared. Results: The mean alpha-1 antitrypsin level in idiopathic interstitial pneumonia patients was 1.67 ± 0.33 g/L, and it was 1.54 ± 0.37 g/L in patients with nonidiopathic interstitial pneumonia (P = 0.13). Low alpha-1 antitrypsin levels were more frequently observed in nonidiopathic interstitial pneumonia patients compared with idiopathic interstitial pneumonia, but the difference was not statistically significant (8.9% vs. …

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The Effect Of Transcatheter Aortic Valve Implantation On Mean Platelet Volume, Mehmet Burak Özen, Hüseyi̇n Ayhan, Haci Ahmet Kasapkara, Telat Keleş, Tahi̇r Durmaz, Kemal Eşref Erdoğan, Bi̇lge Duran Karaduman, Serdal Baştuğ, Cenk Sari, Abdullah Nabi̇ Aslan, Engi̇n Bozkurt Jan 2017

The Effect Of Transcatheter Aortic Valve Implantation On Mean Platelet Volume, Mehmet Burak Özen, Hüseyi̇n Ayhan, Haci Ahmet Kasapkara, Telat Keleş, Tahi̇r Durmaz, Kemal Eşref Erdoğan, Bi̇lge Duran Karaduman, Serdal Baştuğ, Cenk Sari, Abdullah Nabi̇ Aslan, Engi̇n Bozkurt

Turkish Journal of Medical Sciences

Background/aim: Transcatheter aortic valve implantation (TAVI) is an innovative approach to the treatment of aortic stenosis (AS) as an alternative to surgery in high-risk patients. Mean platelet volume (MPV) is considered an indicator of endothelial dysfunction, platelet function, and activation. In this study, we aimed to investigate MPV changes in patients undergoing TAVI. Materials and methods: This study included 100 patients diagnosed with symptomatic severe AS and treated with TAVI between July 2011 and August 2013. Hematological parameters of the patients were examined prior to the procedure and 24 h, 1 month, and 6 months after TAVI. Results: A statistically …

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The Relationship Between Physical Fitness And Falling Risk And Fear Of Falling Incommunity-Dwelling Elderly People With Different Physical Activity Levels, Mehmet Duray, Arzu Genç Jan 2017

The Relationship Between Physical Fitness And Falling Risk And Fear Of Falling Incommunity-Dwelling Elderly People With Different Physical Activity Levels, Mehmet Duray, Arzu Genç

Turkish Journal of Medical Sciences

Background/aim: The aim of this research was to determine the effects of physical activity level (PAL) and physical fitness on falling parameters in community-dwelling elderly people. Materials and methods: Seventy-six elderly people were grouped as low PAL group (group 1, n: 38) and high PAL (group 2, n: 38) according to their PAL scores. PAL was measured by the Physical Activity Scale for the Elderly and muscle strength, muscle endurance, aerobic endurance, and flexibility tests were applied; body mass index (BMI) was calculated for physical fitness measurement. Fall assessment included falling risk (Berg Balance Scale), dynamic balance (Time Up and …

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Association Of B7-H4 Gene Polymorphisms In Urothelial Bladder Cancer, Asuman Özgöz, Murat Şamli, Deni̇z Di̇nçel, Ahmet Şahi̇n, Ümi̇t İnce, Yeşi̇m Sağlican, Faruk Balci, Hale Şamli Jan 2017

Association Of B7-H4 Gene Polymorphisms In Urothelial Bladder Cancer, Asuman Özgöz, Murat Şamli, Deni̇z Di̇nçel, Ahmet Şahi̇n, Ümi̇t İnce, Yeşi̇m Sağlican, Faruk Balci, Hale Şamli

Turkish Journal of Medical Sciences

Background/aim: We aimed to study polymorphisms of the B7-H4 gene in order to evaluate a possible association in urothelial carcinoma, as it is highly expressed in cancer tissues. Materials and methods: In this study B7-H4 gene rs10754339, rs10801935, and rs3738414 SNPs were studied by PCR-RFLP method in paraffin-embedded tumor specimens from 62 urothelial carcinoma patients and in a control group including 30 patients without bladder cancer. Results: We detected that the rs10754339 polymorphism was more frequent in the cancer patients when compared with the control group (P < 0.05). Only the rs3738414 polymorphism showed a statistically significant difference in frequency between pathologic diagnostic groups. Conclusion: The rs10754339 AA genotype distribution was found to have a higher frequency whereas the rs3738414 AG genotype distribution was lower in the bladder cancer group (P < 0.05). None of the genotype distributions showed a significant difference from the control group for the rs10801935 polymorphism. We conclude that B7-H4 has the potential to be a useful prognostic marker in urothelial carcinoma.

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Evaluation Of Serum Uric Acid Levels In Psoriasis Vulgaris, Emrah Yilmaz, Emi̇ne Tamer, Refi̇ka Ferda Artüz, Seray Külcü Çakmak, Fürüzan Köktürk Jan 2017

Evaluation Of Serum Uric Acid Levels In Psoriasis Vulgaris, Emrah Yilmaz, Emi̇ne Tamer, Refi̇ka Ferda Artüz, Seray Külcü Çakmak, Fürüzan Köktürk

Turkish Journal of Medical Sciences

Background/aim: Psoriasis has been accepted as a systemic disease and it is known to be associated with various disorders including metabolic syndrome. High serum uric acid levels are also associated with the components of metabolic syndrome. In this study, we aimed to determine serum uric acid levels in patients with psoriasis and the association of uric acid levels with disease activity by taking the presence of metabolic syndrome criteria into account, since it is one of the most important factors that affect serum uric acid levels. Materials and methods: In this cross-sectional study, we evaluated 70 psoriasis patients and 70 …

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Attitudes, Wishes, And Needs Of Diabetes Patients And Their Relatives: Turkish Data Fromthe Dawn2 Study, İlhan Tarkun, Suzan Dumanli Özgöksu Jan 2017

Attitudes, Wishes, And Needs Of Diabetes Patients And Their Relatives: Turkish Data Fromthe Dawn2 Study, İlhan Tarkun, Suzan Dumanli Özgöksu

Turkish Journal of Medical Sciences

Background/aim: The DAWN2 (Diabetes Attitudes, Wishes, and Needs) study was conducted in order to ascertain the wishes, needs, and attitudes of diabetes patients, their relatives, and healthcare professionals. The study was conducted across 17 countries, including Turkey, and its objective was to introduce policies that could successfully meet these requirements. In this article, the needs, wishes, and attitudes of diabetes patients and their relatives in Turkey are compared with those from other countries. Materials and methods: Eighty patients with type 1 diabetes, 426 patients with type 2 diabetes, and 126 relatives of patients with diabetes were included in the study. …

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Primary Sjögren's Syndrome In Patients With Celiac Disease, Funda Erbasan, Deni̇z Turgut Çoban, Uğur Karasu, Yeşi̇m Çeki̇n, Bayram Yeşi̇l, Ayhan Hi̇lmi̇ Çeki̇n, Di̇nç Süren, Mustafa Ender Terzi̇oğlu Jan 2017

Primary Sjögren's Syndrome In Patients With Celiac Disease, Funda Erbasan, Deni̇z Turgut Çoban, Uğur Karasu, Yeşi̇m Çeki̇n, Bayram Yeşi̇l, Ayhan Hi̇lmi̇ Çeki̇n, Di̇nç Süren, Mustafa Ender Terzi̇oğlu

Turkish Journal of Medical Sciences

Background/aim: Many autoimmune diseases occur concomitantly with celiac disease (CD). We aimed to determine the frequency of Sjögren's syndrome (SS) in CD patients based on SS-specific serology verified by minor labial salivary biopsy. Materials and methods: Eight-two patients with CD were included in the study. After examination for objective evidence of sicca complex, all patients were tested for serological presence of rheumatoid factor (RF) and antinuclear antibodies (ANAs) and for ANA profile. Minor labial salivary biopsy was performed for patients with positive serology and/or clinical signs of SS. Results: Of the patients included, 24 (29.3%) had dry eye symptoms while …

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Xenobiotic/Drug Metabolizing Enzyme And Tp53 Polymorphisms And Clinical Outcomein Advanced Nonsmall Cell Lung Cancer Patients, Volkan Karacaoğlan, Ahmet Oğuz Ada, Serdar Bi̇lgen, Güzi̇de Tuğba Çeti̇nkaya, Emre Soydaş, Celaletti̇n Semi̇h Kunak, Si̇bel Meryem Alpar, Meral Gülhan, Mümtaz İşcan Jan 2017

Xenobiotic/Drug Metabolizing Enzyme And Tp53 Polymorphisms And Clinical Outcomein Advanced Nonsmall Cell Lung Cancer Patients, Volkan Karacaoğlan, Ahmet Oğuz Ada, Serdar Bi̇lgen, Güzi̇de Tuğba Çeti̇nkaya, Emre Soydaş, Celaletti̇n Semi̇h Kunak, Si̇bel Meryem Alpar, Meral Gülhan, Mümtaz İşcan

Turkish Journal of Medical Sciences

Background/aim: The association between polymorphisms of xenobiotic/drug metabolizing enzymes and TP53 and response to chemotherapy and survival of patients with nonsmall cell lung cancer (NSCLC) are limited and inconclusive. In this study, CYP2E1*5B, CYP2E1*6, CYP2E1*7B, GSTO1 (A140D), and TP53 (Arg72Pro) polymorphisms and response to platinum-based chemotherapy and survival in 137 advanced stage NSCLC patients were investigated. Materials and methods: Genetic polymorphism analyses were determined by polymerase chain reaction (PCR) coupled with restriction fragment length polymorphism (RFLP). Results: The patients with TP53 Pro/Pro variant were more likely to be resistant to chemotherapy than those with Arg/Arg variants with marginal significance (P …

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A Study On The Validity And Reliability Of The Amblyopia Andstrabismus Questionnaire (A&Sq) In Turkish, Hali̇se Çoşkun, Sevi̇nç Taştan, Emi̇ne İyi̇gün, Fati̇h Mehmet Mutlu, Osman Meli̇h Ceylan, Hali̇l İbrahi̇m Altinsoy Jan 2017

A Study On The Validity And Reliability Of The Amblyopia Andstrabismus Questionnaire (A&Sq) In Turkish, Hali̇se Çoşkun, Sevi̇nç Taştan, Emi̇ne İyi̇gün, Fati̇h Mehmet Mutlu, Osman Meli̇h Ceylan, Hali̇l İbrahi̇m Altinsoy

Turkish Journal of Medical Sciences

Background/aim: This study aims to evaluate the reliability and validity of the Amblyopia and Strabismus Questionnaire (A&SQ) that is translated into Turkish. Materials and methods: This is a methodological study. A total of 149 patients took part in the survey research between December 2012 and June 2014 in an university hospital, and 37 were retested. Cronbach's alpha coefficient was used for the questionnaire's reliability analysis. Results: Cronbach's alpha coefficients for the subscales of fear of losing the better eye, distance estimation, visual disorientation, double vision, and social contact and appearance were found to be 0.80, 0.88, 0.95, 0.80, and 0.81, …

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Meloxicam And Diclofenac Do Not Change Vegf And Pdgf-Abserum Levels Of Platelet-Rich Plasma, Burkay Utku, Gürhan Dönmez, Gülri̇z Eri̇şgen, Şenay Akin, Ali̇ Haydar Demi̇rel, Feza Korkusuz, Mahmut Nedi̇m Doral Jan 2017

Meloxicam And Diclofenac Do Not Change Vegf And Pdgf-Abserum Levels Of Platelet-Rich Plasma, Burkay Utku, Gürhan Dönmez, Gülri̇z Eri̇şgen, Şenay Akin, Ali̇ Haydar Demi̇rel, Feza Korkusuz, Mahmut Nedi̇m Doral

Turkish Journal of Medical Sciences

Background/aim: Platelet-rich plasma (PRP) application has gained widespread interest for musculoskeletal injuries. Nonsteroidal antiinflammatory drugs are frequently used in sports medicine before and/or after PRP application. Our study seeks to determine whether serum levels of platelet-derived growth factor-AB (PDGF-AB) and vascular endothelial growth factor (VEGF) levels of PRP would be affected by nonsteroidal antiinflammatory drugs. Materials and methods: Two different final concentrations of diclofenac (0.5 6mu;g mL-1 and 2.5 6mu;g mL-1), meloxicam (0.8 μg mL-1 and 2.0 μg mL-1), and acetylsalicylic acid (final concentration 450 μm) were obtained in separate tubes with PRPs prepared from 20 healthy male volunteers. Medicine-free …

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Allergic And Autoimmune Disorders In Families With Selective Iga Deficiency, Mustafa Erkoçoğlu, Ayşe Meti̇n, Ayşenur Kaya, Celal Özcan, Ayşegül Akan, Ersoy Ci̇velek, Murat Çapanoğlu, Tayfur Gi̇ni̇ş, Can Naci̇ Kocabaş Jan 2017

Allergic And Autoimmune Disorders In Families With Selective Iga Deficiency, Mustafa Erkoçoğlu, Ayşe Meti̇n, Ayşenur Kaya, Celal Özcan, Ayşegül Akan, Ersoy Ci̇velek, Murat Çapanoğlu, Tayfur Gi̇ni̇ş, Can Naci̇ Kocabaş

Turkish Journal of Medical Sciences

Background/aim: IgA deficiency is the most common human primary immunodeficiency. The prevalence of allergic disorders and autoimmunity is thought to be increased in selective IgA deficiency (sIgAD). However, it is currently unclear if these disorders coincide within these families. We aimed to evaluate the frequency of allergic and autoimmune disorders in children with sIgAD and their firstdegree relatives (FDRs). Materials and methods: The study included 81 children diagnosed with sIgAD and 274 of their FDRs. The presence of allergic and autoimmune disorders was evaluated and serum antithyroglobulin and antithyroid peroxidase levels were measured in both patients and their first-degree relatives. …

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Association Of The Cetp Gene Taqib And D442g Polymorphisms With Essentialhypertension In The Chinese Mongolian Population, Shudong Niu, Xiaoming Tao, Jingping Li, Yongyue Liu, Jian Wang, Mingyu Cong, Keyong Zhang, Wenyu Zhou, Changchun Qiu Jan 2017

Association Of The Cetp Gene Taqib And D442g Polymorphisms With Essentialhypertension In The Chinese Mongolian Population, Shudong Niu, Xiaoming Tao, Jingping Li, Yongyue Liu, Jian Wang, Mingyu Cong, Keyong Zhang, Wenyu Zhou, Changchun Qiu

Turkish Journal of Medical Sciences

Background/aim: This study aimed to explore the associations of the cholesteryl ester transfer protein (CETP) gene TaqIB and D442G polymorphisms with essential hypertension (EH). Materials and methods: In this case-control study, 883 hypertensive patients and 1044 normal controls were randomly selected from the Mongolian population of China. Polymerase chain reaction (PCR) and direct sequencing of PCR products were used to identify the genotypes. Haplotype analysis was performed by estimating the haplotype frequencies using the online SHEsis package. Results: The distribution frequency of the B2-G haplotype was significantly lower in the EH group than in the control group (0.7% vs. 1.9%, …

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Wheezing, Asthma, And Atopy In Premature Infants At 2 Years Of Age, Sevi̇m Ünal, Ayşenur Kaya, Leyla Bi̇lgi̇n, Emi̇ne Di̇bek Misirlioğlu, Can Naci̇ Kocabaş Jan 2017

Wheezing, Asthma, And Atopy In Premature Infants At 2 Years Of Age, Sevi̇m Ünal, Ayşenur Kaya, Leyla Bi̇lgi̇n, Emi̇ne Di̇bek Misirlioğlu, Can Naci̇ Kocabaş

Turkish Journal of Medical Sciences

Background/aim: We aimed to evaluate wheezing, bronchial asthma (BA), and atopy in premature infants at 2 years of age via a crosssectional study. Materials and methods: Premature infants at <37 weeks of gestational age (GA) were assessed for atopy by skin-prick test and serum immunoglobulin E level at 2 years of age. The family's and infant's histories of allergy, BA, atopy, and wheezing were obtained by questionnaire and from hospital records. Results: There were 98 infants, with mean birth weight (BW) 1517.4 ± 486.5 g and GA 30.8 ± 2.9 weeks. The frequencies of wheezing, asthma, and bronchopulmonary dysplasia (BPD) were 32.7%, 16.3%, and 14.3%, respectively. Skin-prick tests were positive for 11 subjects, with allergy to cereals for 7 infants, egg for 3, and peanut for 1. Wheezing was related to GA, BW, respiratory distress syndrome, mechanical ventilation, sepsis, asphyxia, smoking, antenatal steroid, BA, palivizumab prophylaxis, number of people in the household, and duration of hospitalization (P < 0.05). Wheezing was negatively correlated to GA. Family history of BA, smoking, and number of people in the household were linked to BA (P < 0.05). Conclusion: Wheezing was related to degree of premature birth, but BA was linked to BA in the family and smoking. Increased gestation should improve the infant's respiratory health up to 2 years of age.

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