Medicine and Health Sciences Commons^™

Senior Bsn Students’ Confidence, Comfort, And Perception Of Readiness For Practice, Megan Ashley Wray

Undergraduate Honors Theses

In order for new graduate nurses to practice confidently, senior nursing students must be adequately prepared to assume the role of a nurse in a professional setting. This study, using the Casey-Fink Readiness for Practice Survey, focused on identifying senior Bachelor of Science in Nursing (BSN) students’ level of comfort/confidence performing various skills and perception of readiness for practice as new graduate nurses. All participants had recently completed their senior preceptorship course. Participants completed the survey and descriptive statistics were used to analyze data, while free response answers were studied and key words were identified to categorize responses into themes. …

Move More, Stress Less: Exploring The Relationship Between Physical Activity And Test Anxiety In Undergraduate Nursing Students, Ashleigh Cleveland

Undergraduate Honors Theses

The purpose of this study was to determine the relationship between physical activity and test anxiety in undergraduate baccalaureate nursing students. Participants (N=69) were first, second, and third year undergraduate nursing students at a small, private university in the southeastern United States. The Westside Test Anxiety Scale was administered along with questions regarding the type of physical activity performed each week and the number of minutes of physical activity performed each week. A Pearson r correlation coefficient and descriptive statistics were analyzed. Results were inconclusive regarding the relationship between physical activity and test anxiety. Survey results indicated 97% of students …

A Comparison Of Traditional Epidural And Low-Dose Epidural Techniques, Ellen Terry

Undergraduate Honors Theses

The purpose of this thesis was to compare traditional epidural analgesia to other low-dose epidural analgesic techniques e.g. combined spinal-epidural analgesia and mobile epidural analgesia. The risk and side-effects of each type of epidural had on both mother and the newborn was researched and discussed. This was a comprehensive analysis of several studies dating from 1989 to 2016. It was found that traditional epidural analgesia increased the risk for cesarean deliveries, vaginal assisted deliveries, longer duration of labor, postpartum hemorrhage, breastfeeding cessation, higher temperature, lower maternal satisfaction and failed catheters. No effect on the newborn was found. Combined spinal was …

Innovation And Collaboration: Creating A Transdisciplinary Childhood Obesity Prevention Graduate Certificate Program, Becky Jensen, Mindy Anderson-Knott, Mary Bowne, Linda Boeckner, Suzanne Stluka, Kendra Kattelmann, Jessica Meendering

Health and Nutritional Sciences Faculty Publications

Preparing future professionals to work in transdisciplinary settings with a skill set to effectively foster collaborations and sustainable change requires a thoughtful and concerted interprofessional educational approach. Through an inter-university partnership in 2010 with name of university and the name of university, a group of faculty convened to propose the Transdisciplinary Obesity Prevention (TOP) graduate certificate program. With funding supported by a United States (US) Department of Agriculture (USDA) National Institute of Food and Agriculture grant in 2011, a team of faculty from name of university and name of university representing various disciplines (exercise science, nutrition, dietetics, health promotion, public …

Risk Of Glucose Intolerance And Gestational Diabetes Mellitus In Relation To Maternal Habitual Snoring During Early Pregnancy., Chunfang Qiu, Wayne Lawrence, Bizu Gelaye, Lee Stoner, Ihunnaya O Frederick, Daniel A Enquobahrie, Tanya K Sorensen, Michelle A Williams

Articles, Abstracts, and Reports

BACKGROUND: Obstructive sleep apnea (OSA) or habitual snoring is known to be associated with impaired glucose tolerance and type 2 diabetes among both men and non-pregnant women. We examined the association of habitual snoring during early pregnancy with risk of impaired glucose tolerance (IGT) and gestational diabetes mellitus (GDM).

METHODS: A cohort of 1,579 women was interviewed during early pregnancy. We collected information about snoring frequency during early pregnancy. Results from screening and diagnostic tests for IGT and GDM were abstracted from medical records. Multivariate logistic regression models were fitted to estimate odds ratios (OR) and 95% confidence intervals (95% …

The Big Patent Short: Hedge Fund Challenges To Pharmaceutical Patents And The Need For Financial Regulation, Ariel D. Multak

Fordham Journal of Corporate & Financial Law

The enactment of the America Invents Act (AIA) in 2011 ushered in a new system for post-grant patent review. In the interest of enhancing the efficiency of the patent regime by invalidating “bad” patents, certain requirements were relaxed. For example, the AIA created an examination process called inter partes review, which allows a party without legal standing to challenge the validity of a patent in front of the Patent Trial and Appeal Board. In the pharmaceutical patent context, it was expected that inter partes review would be utilized mostly by generic drug makers seeking to invalidate patents without incurring the …

Neurobiology Of The Premonitory Urge In Tourette's Syndrome: Pathophysiology And Treatment Implications, Andrea E Cavanna, Kevin J. Black, Mark Hallett, Valerie Voon

2010-2019 OA Pubs

Motor and vocal tics are relatively common motor manifestations identified as the core features of Tourette's syndrome (TS). Although traditional descriptions have focused on objective phenomenological observations, such as anatomical location, number and frequency of tics, patients' first-person accounts have consistently reported characteristic subjective correlates. These sensory phenomena are often described as a feeling of mounting inner tension or urge to move ("premonitory urge"), which is transiently relieved by tic expression. This article reviews the existing literature on the clinical and neurobiological aspects of the premonitory urge in patients with TS, with focus on its pathophysiology and possible treatment implications.

International Education For Medical Students: An International Program Design In Publich Health, Elizabeth Anne Tyrie

Capstone Collection

Cultural Perspectives in Public Health: An International Education Program for Medical Students proposes a six-week international mobility course for medical students at Università Cattolica del Sacro Cuore. The course design was inspired by a request from the UCSC medical student cohort to expand credit-bearing international program opportunities. The program will introduce participants to Kolb’s (1984) experiential learning cycle in an effort to provide students with a framework to use when evaluating common practices in the medical field. The course aims to increase academic collaboration between Università Cattolica del Sacro Cuore, an Italian based Higher Education Institution, and the Higher Education …

Music, Healing, And Conflict: Balancing Science And Intuition, Marisa K. Massery

Capstone Collection

Music move us personally and with more meaning than any other medium in the world. In the past few decades, modern advances in neuroscience have proved via neuroimaging that musical processing involves almost every region of the brain, a task that no other stimulus can achieve. Science can show what is happening in our brain, but humans have intuitively known and utilized music for healing purposes since the beginning of humanity. This research examines the dynamics of continued scientific advancement in light of Non-Western ways of knowing. The study is an attempt to shorten the distance between music, healing and …

Exploring The Multidimensional Structure Of The Wasi-Ii: Further Insights From Schmid-Leiman Higher-Order And Exploratory Bifactor Solutions, Brittany Mcgeehan, Nadine Ndip, Ryan J. Mcgill

Archives of Assessment Psychology

The Wechsler Abbreviated Scale of Intelligence-Second Edition (WASI-II; Wechsler, 2011a) is a versatile and widely utilized brief intelligence measure by assessment psychologists in a variety of clinical settings. Despite the fact that a hierarchical measurement model is implied in the WASI-II Manual (Wechsler, 2011b) and the scores provided by the instrument, a hierarchical measurement model was not specified in the structural validation studies conducted by the test publisher. Due to this shortcoming, two exploratory factor analytic methods (Schmid-Leiman [SL] and exploratory bifactor analysis [EBFA]) were utilized to disclose the higher-order structuring of WASI-II variables. Results from both solutions indicated that …

Localization Of Fam171b Mrna Expression In Mouse Brain Using In-Situ Hybridization, Ashani Kumudika Sudasinghe

All Graduate Theses, Dissertations, and Other Capstone Projects

Proteins containing polyglutamine (polyQ) tracts within their primary amino acid sequence are particularly interesting because expansion mutation within them has been shown to underlie a growing list of severe neurodegenerative disorders including Huntington's Disease and several types of Spinocerebellar Ataxias. FAM171B is a novel polyQ protein that was originally identified via large scale sequencing efforts. However, to date, very little is known regarding its normal cellular function and expression pattern. In this study, in situ hybridization was utilized to assess whether FAM171B is expressed in developing (postnatal days 7, 21, 42) and adult mouse brains. The results of the experiments …

Validating Drug Targets Through Inhibition Of Protein-Protein Interactions In Mycobacterium Tuberculosis, Erin C. Driscoll

Honors Undergraduate Theses

Tuberculosis is the leading cause of death by single infectious disease worldwide; novel antibiotics are needed to continue to treat this disease. To goal of this project is to provide proof-of-principle support for the idea that targeting protein-protein interactions (PPI) is an appropriate course for the discovery of new drugs. This study optimized the M-PFC assay, which allows detection of PPI in Mycobacteria, through the use of stronger promoters and inducible expression of a peptide blocker by riboswitch. To accomplish this, promoter induction studies were used to find stronger promoters for the M-PFC, optimization of the riboswitch as a …

Profit-Bearing Administrators: Exploring The Application Of Economics And Financial Concepts In Healthcare Management, Brandon K. Riddick

Honors Undergraduate Theses

Healthcare managers face an incredible challenge today; understanding and implementing financially and economically sound decisions in the complex healthcare environment of the United States. The pressure to be profitable managers is greater than ever. Considering current research, past studies, and articles focused on the demands of healthcare managers will illuminate the state of health care administration, and the importance of real world application of accounting and economics in healthcare.

This thesis will explore and examine research about industry standards, and the need for preparedness in healthcare finance management. It will also examine the important and complex role of accounting and …

Predicting Patients' Trust In Physicians From Personality Variables, Ethnicity, And Gender, Zoreed A. Mukhtar

Honors Undergraduate Theses

This study examined variables related to the doctor-patient interaction that can predict college students’ trust in their physicians. Specifically, I examined if five personality variables, ethnicity, and gender were associated with attitudes toward physicians. A second aim of the study was to determine if there was a difference in the level of trust in physicians between pre-medical and non-pre-medical students. Surveys were administered to UCF students containing a series of questions compiled from the Interpersonal Physician Trust Scale, Interpersonal Trust Scale, Illness Attitude Scale, Big Five Inventory, Martin-Larsen Approval Motivation Scale-Short Form, Almost Perfect Scale-Revised and Marlowe-Crowne Social Desirability Scale-Short …

Improved Physiology And Psychosocial Well-Being For Children With Physical Disabilities Through Virtual Reality Immersion, Bethany D. Fralish

Honors Undergraduate Theses

The purpose of this case study was to examine the physiological and psychosocial effects of an immersive virtual reality (VR) system in a female, young adult with right side paralysis following a left hemisphere brain bleed in order to determine the usefulness of immersive VR for children with physical disabilities, in particular, cerebral palsy (CP). The current study consisted of six sessions over a span of three weeks, with each session lasting approximately 45 minutes. Physiological factors (upper body mobility, heart rate variability) were assessed via a hand use questionnaire and a heart rate monitor, while psychosocial factors (e.g. positive …

Receptive And Expressive Single Word Vocabulary Errors Of Preschool Children With Developmental Disabilities, Juliana L. Hirn

Honors Undergraduate Theses

Vocabulary growth during the preschool years is critical for language development. Preschool children with developmental disabilities often have more difficulty with learning and developing language, therefore making more errors in vocabulary. It is important to recognize what type of errors children are demonstrating, especially as it relates to receptive and expressive language abilities. This study explores the error patterns preschool children with developmental disabilities make during receptive and expressive single word vocabulary tests. A secondary analysis of preexisting data was conducted from a sample of 68 preschool children with developmental disabilities ranging in severity. Based on a coding system developed …

Activation And Expansion Of Natural Killer Cells For Cancer Immunotherapy With Ex21 Exosomes, Sara Khederzadeh

Honors Undergraduate Theses

In the field of cancer immunotherapy, NK cells are recognized for their ability to provide a form of innate immunity against tumor cells. However, the average abundance of NK cells in the blood can be as low as 5% of the total lymphocyte population. As a result, it has been a focus to find novel therapies to expand NK cells in vitro while subsequently enhancing the cytotoxicity of these cells. Previously-defined methods include the minimal expansion of NK cells with high levels of cytokines such as IL-2 and IL-15, as well as co-culturing NK cells with feeder cell populations that …

Examination Of The Rehabilitation Protocol Of Traumatic Transfemoral Amputees And How To Prevent Bone Mineral Density Loss, Emily R. Jenkinson

Honors Undergraduate Theses

The purpose of this literature review was to identify any adaptations that could be made to the rehabilitation process for Traumatic Transfemoral Amputees. Traumatic Transfemoral Amputation is particularly debilitating with the amputees encountering many obstacles throughout the rehabilitation process. These obstacles can prevent the return to pre-morbid functioning. With an ever-increasing number of amputees within the United States, it is imperative the rehabilitation process be addressed. This literature review addresses possible adjustments in the initial stages of rehabilitation examining the post-operative, pre-prosthetic, and prosthetic rehabilitation stage to enhance the physical functioning for the amputee. This comprehensive literature review encompassing 63 …

Micro-Spectroscopy Of Bio-Assemblies At The Single Cell Level, Jeslin Kera

Honors Undergraduate Theses

In this thesis, we investigate biological molecules on a micron scale in the ultraviolet spectral region through the non-destructive confocal absorption microscopy. The setup involves a combination of confocal microscope with a UV light excitation beam to measure the optical absorption spectra with spatial resolution of 1.4 μm in the lateral and 3.6 μm in the axial direction. Confocal absorption microscopy has the benefits of requiring no labels and only low light intensity for excitation while providing a strong signal from the contrast generated by the attenuation of propagating light due to absorption. This enables spatially resolved measurements of single …

Effects Of An Acute High-Volume Isokinetic Intervention On Circulating Levels Of Tnf-Α And Stnfr: Influence Of Age, Eliott Arroyo Delgado

Electronic Theses and Dissertations

The immune system has been implicated in recovery and muscle regeneration following exercise. In response to muscle damage, the immune system responds with an increase in circulating pro-inflammatory cytokines with the goal of recruiting leukocytes to the damaged area. Tumor Necrosis Factor-alpha (TNF-α), in particular, has been shown to be implicated in both muscle regeneration and muscle wasting. However, it remains unclear whether TNF-α is responsible for the age-related losses in muscle size and function. Also, due to the high clearance rate of TNF-α from circulation, analyzing the circulating levels of soluble TNF-α receptors 1 and 2 (STNFR1 and STNFR2) …

Effects Of An Acute High-Volume Isokinetic Intervention On Inflammatory And Strength Changes: Influence Of Age, Joseph Gordon

Electronic Theses and Dissertations

PURPOSE: The purpose of this study was to compare the effects of a high volume isokinetic intervention on lower body strength and inflammation, as well as markers of muscle damage in the subsequent 48 hours between younger and middle-aged men. METHODS: 19 healthy, recreationally trained men were randomly assigned to two groups, younger adults (YA: 21.8 ± 2.0 y; 90.7 ± 11.6 kg; 21.5 ± 4.1 % body fat), or middle-aged adults (MA: 47.0 ± 4.4 y; 96.0 ± 21.5; 24.8 ± 6.3 % body fat). Both groups reported to the human performance laboratory (HPL) on four separate occasions. On …

Consequences Of Altered Short-Chain Carbon Metabolism In Heart Failure, Julie Horton

Electronic Theses and Dissertations

Cardiovascular disease is currently the foremost cause of death within the United States. Heart failure (HF) is a syndrome defined by the inability of the heart to adequately execute requisite pump function in order to deliver nutrients and oxygen to peripheral tissues, irrespective of etiology. One of the most common causes of HF is chronic pressure overload due to hypertension. Ischemic heart disease is also a common driver of HF, often in conjunction with hypertension. Pressure overload initially causes compensatory metabolic changes. Structural changes follow shortly thereafter typically resulting in left ventricular hypertrophy. Eventually, the heart loses the ability to …

Let Them Frye: Frye Hearings For Determination Of "Mental Disorders" In The Sexually Violent Persons Act, Hannah Henkel

Journal of Criminal Law and Criminology

Specific laws aimed at the confinement of mentally disabled sexually violent persons have existed for years. Originally, these laws aimed to rehabilitate a person within a mental hospital and help him with his disorders, aiming to help him enter back into society. However, throughout the years, the laws morphed into ways to keep convicted criminals from society after their prison sentence ended for fear of potential future crimes. In Illinois, the courts find a man falls within the sexually violent persons law when he remains too dangerous to be released after his criminal confinement. A person must have a “mental …

Chromosomal Findings And Sequence Analysis Of Target Exons Of Calcium-Sensingreceptor (Casr) Gene In Patients With Sagliker Syndrome, Erdal Tunç, Osman Demi̇rhan, Yahya Sağliker, İsmai̇l Yildiz, Nuray Paylar, Ali̇ İrfan Güzel

Turkish Journal of Medical Sciences

Background/aim: Sagliker syndrome (SS) develops as a continuation of chronic kidney disease and secondary hyperparathyroidism conditions. It was thought that there are some genetic predisposition factors leading to SS. The calcium-sensing receptor (CaSR) is essential for calcium homeostasis in the body. We aimed to examine SS patients for chromosome aberrations (CAs) and CaSR gene abnormalities in exons 2 and 3. Materials and methods: Twenty-three patients and 23 control subjects were admitted to Balcalı Hospital of the Medical Faculty of Çukurova University in Turkey between 2009 and 2011. Chromosomal analysis was performed according to standard cytogenetic methods. Full sequencing of exons …

Pooled Analysis Of 899 Nosocomial Meningitis Episodes From Turkey, Oğuz Reşat Si̇pahi̇, Arzu Nazli Zeka, Meltem Taşbakan, Hüsnü Pullukçu, Bi̇lgi̇n Arda, Tansu Yamazhan, Hi̇lal Si̇pahi̇, Sercan Ulusoy

Turkish Journal of Medical Sciences

Background/aim: Healthcare-associated meningitis (HCAM) is a relatively rare entity with significant morbidity and mortality. The aim of this study was to systematically review the Turkish medical literature for acute nosocomial meningitis. Materials and methods: One national (ULAKBİM) and two international (www.scopus.com and www.pubmed.com) databases were searched. In addition, abstracts of four national congresses held between 2004 and 2013 were searched for reports for HCAM meningitis. Results: Data for 899 HCAM meningitis episodes were obtained from 24 reports. In terms of clinical findings, 177 of 216 (81.9%) had fever (>38 °C), 55 of 64 (85.9%) had high CRP levels, 105 …

Potential Drug-Drug Interactions Among Prescriptionsfor Elderly Patients In Primary Health Care, Zafer Gören, Mahluga J. Demirkapu, Gökçe Akpinar Acet, Sanda Çali, Medine Gülçebi̇ İdri̇z Oğlu

Turkish Journal of Medical Sciences

Background/aim: Elderly patients are at high risk from drug-drug interactions (DDIs). This study evaluates the potential DDIs in Turkish elderly patients at a primary health care outpatient clinic. Materials and methods: Online database systems were used to examine DDIs on the prescriptions of patients (n = 1206). The clinical severity of DDIs was classified by the Lexi-Interact Online database. Results: Of the 5059 prescriptions, 33% were found to have DDIs. We detected 29 (0.9%) A, 380 (11.8%) B, 2494 (77.7%) C, 289 (9%) D, and 18 (0.6%) X risk rating category DDIs among the prescriptions. Prescriptions of female patients and …

Intravitreal Prn Ranibizumab Treatment For Macular Edemadue To Branch Retinal Vein Occlusion, Hasan Basri̇ Çakmak, Mücella Arikan Yorgun, Yasi̇n Toklu, Melek Mutlu

Turkish Journal of Medical Sciences

Background/aim: To evaluate the effect of intravitreal pro re nata (PRN) ranibizumab treatment from the start on the best-corrected visual acuity (BCVA) and the central retinal thickness (CRT) in macular edema (ME) due to branch retinal vein occlusion (BRVO). Materials and methods: Patients with ME secondary to BRVO, who were treated on a PRN basis after a single intravitreal ranibizumab injection, were retrospectively evaluated. The main outcome measures were changes in BCVA and CRT as measured by optical coherence tomography. Results: The number of injections over 6 months was 2.43 ± 1.16. The mean BCVA of the patients was 0.84 …

Determination Of The Ideal Sampling Technique To Reduce Repeated Procedures:A Comparative Study Including 393 Fine-Needle Aspirations For Thyroid Nodules, Fati̇h Uzunkaya, Ahmet Özden

Turkish Journal of Medical Sciences

Background/aim: Fine-needle aspiration biopsy is an established method for the evaluation of thyroid nodules, but it has not been standardized worldwide yet. Adequacy of the aspirations is affected by several factors. The aim of this study is to determine the main factors affecting the adequacy and to suggest a procedural technique expected to reduce repeated procedures. Materials and methods: A total of 393 aspiration procedures performed using either 22-gauge or 27-gauge needles were included in the study. The samplings were classified as inadequate or adequate according to the cytopathological reports, and results were compared. Results: The rate of adequate samplings …

Prevalence And Associated Factors Of Thrombocytopenia Among Human Immunodeficiency Virus-Infected Patients At A Tertiary Care Hospital In İzmir, Turkey, Can Hüseyi̇n Heki̇moğlu, Fi̇gen Kaptan, İlknur Vardar, Serap Ural, Nesri̇n Türker, Bahar Örmen, Nurbanu Sezak, Si̇bel El

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to determine the prevalence and associated factors of thrombocytopenia in human immunodeficiency virus (HIV)-infected patients. Materials and methods: A cross-sectional study was conducted in a tertiary care hospital in İzmir, Turkey. All HIV-infected patients admitted to the Department of Infectious Diseases and Clinical Microbiology between 2006 and 2011 were recruited. Patients with thrombocytopenia at any time point were defined as the case group and the remaining patients were defined as the control group. Results: The frequency of thrombocytopenia was 35.8%. Thrombocytopenia was more frequent in patients with acquired immune deficiency syndrome (AIDS) than …

Relation Of Unsupported And Unsupervised Exercise With Anthropometric And Biochemical Indices Among Type 2 Diabetic Patients, Prince Chikwere, Kwabena Nsiah, Marina Tandoh

Turkish Journal of Medical Sciences

Background/aim: Type 2 diabetes is a lifestyle-related condition. Lifestyle modification in the management of type 2 diabetes incorporates exercise. The aim of this study was to find out how unsupported and unsupervised exercise relates to anthropometric indices and biochemical indices in type 2 diabetes patients. Materials and methods: In the cross-sectional study, a structured questionnaire was used to access data on the exercise history of patients. Subjects were classified according to exercise intensity. The dietary intake of patients was obtained by 24-h recall. Standard measurements were taken of waist circumference and blood pressure. Blood samples were also collected to measure …