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2017

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Articles 11311 - 11340 of 14524

Full-Text Articles in Medicine and Health Sciences

Thyroid Malignancy Risk In Different Clinical Thyroid Diseases, Ahmet Di̇ri̇koç, Sevgül Faki, Hüsni̇ye Başer, Di̇dem Özdemi̇r, Cevdet Aydin, Reyhan Ersoy, Mehmet Kiliç, Aydan Kiliçarslan, Beki̇r Çakir Jan 2017

Thyroid Malignancy Risk In Different Clinical Thyroid Diseases, Ahmet Di̇ri̇koç, Sevgül Faki, Hüsni̇ye Başer, Di̇dem Özdemi̇r, Cevdet Aydin, Reyhan Ersoy, Mehmet Kiliç, Aydan Kiliçarslan, Beki̇r Çakir

Turkish Journal of Medical Sciences

Background/aim: To evaluate the malignancy risk of thyroid nodules in different clinical thyroid diseases. Materials and methods: Patients who underwent thyroidectomy between 2007 and 2014 were grouped as euthyroid, hypothyroid, and hyperthyroid. Further classification was made depending on the presence of solitary/multiple thyroid nodules. Results: Among 2870 patients, 1719 (59.9%) were euthyroid, 962 (33.5%) were hyperthyroid, and 189 (6.6%) were hypothyroid. Overall malignancy was detected in 980 (34.1%) patients. Malignancy rates were 42.1%, 42.9%, and 18.3% in the euthyroid, hypothyroid, and hyperthyroid groups, respectively (P < 0.001). A total 41.4% of patients with euthyroid nodular goiter (ENG) and 46.3% of patients with euthyroid multinodular goiter (EMNG) had thyroid malignancy (P = 0.169). Mean tumor size and capsular and vascular invasion were significantly lower in EMNG than in ENG. Among hypothyroid patients, 45.7% with solitary and 42.2% with multiple nodules were malignant (P = 0.705). When toxic nodular goiter and toxic multinodular goiter were analyzed together, malignancy rate was 24.7% (104/421), and when Graves with nodule/nodules was considered, it was 19.7% (59/299). Conclusion: In hypothyroid or euthyroid patients who underwent thyroidectomy, malignancy rate was higher than 40%, and was lower in hyperthyroid patients. Patients with multiple nodules carry a similar risk of malignancy as patients with solitary nodules, independent of the functional status.

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Mean Adc Values Discriminate Rectal Mucinous Carcinomafrom Rectal Nonmucinous Adenocarcinoma, Hale Çolakoğlu Er, Gül Ayşe Erden Jan 2017

Mean Adc Values Discriminate Rectal Mucinous Carcinomafrom Rectal Nonmucinous Adenocarcinoma, Hale Çolakoğlu Er, Gül Ayşe Erden

Turkish Journal of Medical Sciences

Background/aim: This study aimed to differentiate rectal mucinous carcinoma (MC) from nonmucinous rectal adenocarcinoma (AC) using mean apparent diffusion coefficient (mADC) values obtained with diffusion-weighted imaging.Materials and methods: Sixty-two pathologically confirmed rectal AC (n = 44) and MC (n = 18) patients were included in this study. The two groups underwent pelvic MRI to determine the local staging baseline for rectal tumors. Once the region of interest (ROI) was determined, a border was drawn around each hyperintense tumor (b = 1000 s/mm2 images). Following a repeat of this procedure for each patient, the ROIs were recorded to apparent diffusion coefficient …

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Evaluation Of Pulmonary Vein Anatomy Using 256-Slice Computed Tomography, Yinghong Shi, Shaohua Mi, Yunxia Shi, Hongbo Wang, Jian Li, Benxia Yu, Fengli Liu, Heng Ma, Bin Wang Jan 2017

Evaluation Of Pulmonary Vein Anatomy Using 256-Slice Computed Tomography, Yinghong Shi, Shaohua Mi, Yunxia Shi, Hongbo Wang, Jian Li, Benxia Yu, Fengli Liu, Heng Ma, Bin Wang

Turkish Journal of Medical Sciences

Background/aim: This study aimed to evaluate pulmonary vein (PV) anatomy using 256-slice computed tomography (CT), which may be necessary for electrophysiologists to know before radiofrequency catheter ablation (RFCA) therapy.Materials and methods: A total of 102 patients with paroxysmal and persistent atrial fibrillation underwent 256-slice cardiac CT angiography prior to catheter ablation. PV morphology, ostial diameter, ostial orientation, and distance from ostium to first bifurcation were evaluated using three-dimensional volume-rendering and multiplanar-reformatting technology. Results: We found that 72.5% of patients had four conventional PVs. On the right, 22.5% of patients had one accessory PV, 4.9% had 2 accessory PVs, 1% had …

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Polymorphisms Of Cancer-Related Genes And Risk Of Multipleprimary Malignancies Involving Colorectal Cancer, Peiguo Cao, Li Yu, Anshan Wu, Jingjing Li, Ling Liu, Chunlan Liu, Jianda Zhou, Ke Cao, Chengxian Guo Jan 2017

Polymorphisms Of Cancer-Related Genes And Risk Of Multipleprimary Malignancies Involving Colorectal Cancer, Peiguo Cao, Li Yu, Anshan Wu, Jingjing Li, Ling Liu, Chunlan Liu, Jianda Zhou, Ke Cao, Chengxian Guo

Turkish Journal of Medical Sciences

Background/aim: This study aimed to investigate the relationship between single nucleotide polymorphisms (SNPs) of cancer-related genes and the risk of multiple primary malignancies involving colorectal cancer.Materials and methods: We collected tissue samples from 22 multiple primary cancer patients with primary colorectal cancer and performed genotyping assay for 116 SNP loci from 62 genes encoding peptides functioning in various signaling pathways using the DNA MassARRAY system. The chi-square test was used to compare the differences in base frequencies between patients and a control Chinese population from HapMap through the NCBI database.Results: No significant differences in frequencies were detected for 81 SNPs …

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Isolated Sphenoid Sinus Pathologies: A Series Of 40 Cases, Faki̇h Ci̇hat Eravci, Alper Ceylan, Mehmet Göcek, Fi̇kret İleri̇, Süleyman Sabri̇ Uslu, Meti̇n Yilmaz, Yusuf Kizil Jan 2017

Isolated Sphenoid Sinus Pathologies: A Series Of 40 Cases, Faki̇h Ci̇hat Eravci, Alper Ceylan, Mehmet Göcek, Fi̇kret İleri̇, Süleyman Sabri̇ Uslu, Meti̇n Yilmaz, Yusuf Kizil

Turkish Journal of Medical Sciences

Background/aim: Isolated sphenoid sinus-derived lesions are rare and generally present with unclear symptoms. We are sharing our experience to be mindful of such lesions in differential diagnosis and to help accomplish successful treatment while avoiding revisions and complications.Materials and methods: Data from patients who underwent isolated sphenoid sinus surgeries (ISSs) were retrospectively extracted from the period of January 2005 to August 2015. Demographic data, chief complaints and presenting symptoms, imaging findings, surgical management, and results were evaluated. Results: There were 40 patients who underwent ISS. These patients had different pathologies. The chief complaint was nonspecific headache, except for cerebrospinal fluid …

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Investigation Of Glucocorticoid Receptor And Calpain-10 Gene Polymorphisms In Turkish Patients With Type 2 Diabetes Mellitus, Naci̇ye Selcen Bayramci, Leyla Açik, Çağdaş Kalkan, İlhan Yetki̇n Jan 2017

Investigation Of Glucocorticoid Receptor And Calpain-10 Gene Polymorphisms In Turkish Patients With Type 2 Diabetes Mellitus, Naci̇ye Selcen Bayramci, Leyla Açik, Çağdaş Kalkan, İlhan Yetki̇n

Turkish Journal of Medical Sciences

Background/aim: We proposed to investigate the role of calpain-10 (CAPN10) gene single nucleotide polymorphism (SNP)-19 and SNP-44 and glucocorticoid receptor (NR3C1) gene N363S polymorphisms in Turkish patients with type 2 diabetes mellitus (T2DM).Materials and methods: Peripheral blood samples were obtained from 125 patients with T2DM and 112 healthy volunteers. Genotyping was carried out by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: There were no statistically significant differences found between the allele and genotype frequencies of CAPN10 SNP-19, CAPN10 SNP-44, and NR3C1 N363S polymorphisms and T2DM development (P > 0.05). The CAPN10 SNP-19 del-allele, CAPN10 SNP-44 C-allele, and NR3C1 …

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Comparison Of Tidal Volume And Deep Breath Preoxygenation Techniquesundergoing Coronary Artery Bypass Graft Surgery: Effects Of Hemodynamicresponse And Arterial Oxygenation*, Zafer Taş, Tülay Hoşten, Alparslan Kuş, Sevi̇m Cesur, Neşe Türkyilmaz, Ahmet Arikan, Zeynep Mi̇ne Solak Jan 2017

Comparison Of Tidal Volume And Deep Breath Preoxygenation Techniquesundergoing Coronary Artery Bypass Graft Surgery: Effects Of Hemodynamicresponse And Arterial Oxygenation*, Zafer Taş, Tülay Hoşten, Alparslan Kuş, Sevi̇m Cesur, Neşe Türkyilmaz, Ahmet Arikan, Zeynep Mi̇ne Solak

Turkish Journal of Medical Sciences

Background/aim: Different techniques exist for the preoxygenation of patients that will be operated on under general anesthesia. Preoxygenation with the deep breath (DB) method may affect cardiovascular stability, which is crucial for coronary artery bypass graft (CABG) patients. In this study, we aimed to compare the effects of the 3 min TVB preoxygenation technique and 1 min 8DBs technique on hemodynamic response and arterial oxygenation in patients with normal ejection fraction that were scheduled for elective CABG surgery. Materials and methods: Forty patients classified as ASA II?III and scheduled for elective CABG surgery were randomly assigned to TVB/3 min or …

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Efficacy Of Bispectral Index Monitoring For Prevention Of Anestheticawareness And Complications During Oocyte Pick-Up Procedure, Aykut Urfalioğlu, Mahmut Arslan, Süleyman Murat Bakacak, Hafi̇ze Öksüz, Ömer Faruk Boran, Gözen Öksüz Jan 2017

Efficacy Of Bispectral Index Monitoring For Prevention Of Anestheticawareness And Complications During Oocyte Pick-Up Procedure, Aykut Urfalioğlu, Mahmut Arslan, Süleyman Murat Bakacak, Hafi̇ze Öksüz, Ömer Faruk Boran, Gözen Öksüz

Turkish Journal of Medical Sciences

Background/aim: This study was planned by considering that the use of bispectral index (BIS) monitoring ensures sufficient depth of anesthesia and avoids anesthetic awareness and patient movement in the oocyte pick-up (OPU) procedure.Materials and methods: Ninety-eight patients undergoing OPU were randomly divided into 2 groups as the control group (n = 48) and BIS group (n = 50). After propofol and remifentanil induction, the control group was given additional propofol according to reaction response, while the BIS group was given propofol at BIS values of 60 and above with the aim that BIS values be 40?60. Total procedure time, recovery …

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Genotype Distribution Of Mycobacterium Tuberculosis In Theaegean Region And Associated Demographic Factors, Cengi̇z Çavuşoğlu, Fethi̇ye Ferda Yilmaz, İsabel Rai̇ka Durusoy Onmuş, Tuğba Bozdemi̇r, Hüseyi̇n Taşli, Mi̇ne Hoşgör Li̇moncu Jan 2017

Genotype Distribution Of Mycobacterium Tuberculosis In Theaegean Region And Associated Demographic Factors, Cengi̇z Çavuşoğlu, Fethi̇ye Ferda Yilmaz, İsabel Rai̇ka Durusoy Onmuş, Tuğba Bozdemi̇r, Hüseyi̇n Taşli, Mi̇ne Hoşgör Li̇moncu

Turkish Journal of Medical Sciences

Background/aim: The Aegean Region is the second-ranking region in Turkey according to the Human Development Index and population density and it hosts 1/8 of Turkey's population. İzmir is the largest city of the region, receiving internal migration both from inside and outside the region. The tuberculosis incidence in İzmir is lower than overall in Turkey: 17.7/100,000 in 2011. Our aims were to determine genotypes of Mycobacterium tuberculosis isolates; to explore possible associations between genotypes with case-demographic data, clinical presentation, and antimicrobial susceptibility patterns; and to determine variations in genotype distribution of strains isolated in Ege University Hospital, İzmir. Materials and …

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Combined Oral Supplementation Of Chromium Picolinate, Docosahexaenoic Acid, And Boron Enhances Neuroprotection In Rats Fed A High-Fat Diet, Cemal Orhan, Nurhan Şahi̇n, Zeynep Tuzcu, James R. Komorowski, Kazi̇m Şahi̇n Jan 2017

Combined Oral Supplementation Of Chromium Picolinate, Docosahexaenoic Acid, And Boron Enhances Neuroprotection In Rats Fed A High-Fat Diet, Cemal Orhan, Nurhan Şahi̇n, Zeynep Tuzcu, James R. Komorowski, Kazi̇m Şahi̇n

Turkish Journal of Medical Sciences

Background/aim: A novel complex of a nutritional supplement (CDB) contains chromium picolinate (CrPic), phosphatidylserine (PS), docosahexaenoic acid (DHA), and boron (B). The present study aimed to investigate the effects of CDB on the metabolic profile and memory acquisition in rats fed a high-fat diet (HFD). Materials and methods: Male Wistar rats were divided into six groups and received either a regular diet or HFD supplemented with or without different levels of CDB (0, 11, or 22 mg/kg BW). Results: Rats fed the HFD had greater glucose, insulin, lipid profile, and serum malondialdehyde concentrations, but lower serotonin and tryptophan in the …

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Dna Methylation Of The Prestin Gene And Outer Hair Cell Electromotileresponse Of The Cochlea In Salicylate Administration*, Erdoğan Bulut, Meti̇n Budak, Levent Öztürk, Mehmet Turgay Türkmen, Cem Uzun, Tammam Si̇pahi̇ Jan 2017

Dna Methylation Of The Prestin Gene And Outer Hair Cell Electromotileresponse Of The Cochlea In Salicylate Administration*, Erdoğan Bulut, Meti̇n Budak, Levent Öztürk, Mehmet Turgay Türkmen, Cem Uzun, Tammam Si̇pahi̇

Turkish Journal of Medical Sciences

Background/aim: Activity of the prestin gene may have a role in the pathogenesis of salicylate-induced ototoxicity. We investigated DNA methylation for prestin gene exon 1 in salicylate-injected guinea pigs.Materials and methods: Fifteen guinea pigs (30 ears) underwent audiological evaluation including 1000 Hz probe-tone tympanometry and a distortion product otoacoustic emission (DPOAE) test. The animals were randomly divided into three groups. Groups 2 (8 ears) and 3 (14 ears) were injected with intramuscular saline and sodium salicylate (200 mg/kg), respectively twice daily for 2 weeks. Group 1 (8 ears) received no injection. DPOAE measurements were performed at baseline; after 1, 2, …

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The Effects Of Mesenchymal Stem Cells On The Structure And Contractile Force Of The Carotid Artery In A Rat Aneurysm Model, Özbeyen Atalay, Handan Sevi̇m, Seçi̇l Karahi̇sar Turan, Mehmet Ali̇ Onur, Özer Ayli̇n Gürpinar Jan 2017

The Effects Of Mesenchymal Stem Cells On The Structure And Contractile Force Of The Carotid Artery In A Rat Aneurysm Model, Özbeyen Atalay, Handan Sevi̇m, Seçi̇l Karahi̇sar Turan, Mehmet Ali̇ Onur, Özer Ayli̇n Gürpinar

Turkish Journal of Medical Sciences

Background/aim: An aneurysm is a pathological enlargement of an artery characterized by the thinning of the elastic fiber layer in the tunica media. Because the aneuritic artery wall is weakened, these vessels can rupture and cause serious bleeding. Surgical methods are often used for the treatment of aneurysms. However, cell-based therapies are less invasive and potentially safer alternatives. In this study, the therapeutic efficacy of rat adipose tissue-derived mesenchymal stem cells (MSCs) was investigated in a new carotid artery aneurysm model.Materials and methods: Arteries were pretreated with elastase to create aneurysms. Gelatin matrices containing MSCs were applied to the outer …

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Exogenous Erythropoietin Aggravates Retinal Neovascularizationin A Murine Model Of Proliferative Retinopathy, Ning Yang, Wenxi Zhang, Tao He, Yiqiao Xing Jan 2017

Exogenous Erythropoietin Aggravates Retinal Neovascularizationin A Murine Model Of Proliferative Retinopathy, Ning Yang, Wenxi Zhang, Tao He, Yiqiao Xing

Turkish Journal of Medical Sciences

Background/aim: Erythropoietin (EPO) has been proven recently to be a critical mediator in retinal neovascularization (RNV). Previous studies have indicated that the use of recombinant human EPO (rEPO) is a high risk factor in the development of retinopathy of prematurity. In this study, we aimed to investigate the effect of rEPO administration on RNV and its underlying mechanism in a mouse model of oxygen-induced retinopathy (OIR). Materials and methods: A murine model of OIR was used to generate RNV. After daily intraperitoneal injection of rEPO from postnatal day 12 (P12), mice were euthanized at P17. Whole-mount retina staining was used …

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Investigation Of Class-D Beta-Lactamases Causing Carbapenem Resistance In Clinical Acinetobacter Baumannii Isolates*, Iskandar Davandeh, Bayri Eraç, Sabi̇re Şöhret Aydemi̇r Jan 2017

Investigation Of Class-D Beta-Lactamases Causing Carbapenem Resistance In Clinical Acinetobacter Baumannii Isolates*, Iskandar Davandeh, Bayri Eraç, Sabi̇re Şöhret Aydemi̇r

Turkish Journal of Medical Sciences

Background/aim: Acinetobacter baumannii is an important causative agent of nosocomial infections, and carbapenems have been frequently used in the treatment of these infections. This study was designed to investigate the prevalence of primary carbapenem hydrolyzing oxacillinase (CHO) types in clinical A. bumannii strains. Materials and methods: Minimum inhibitory concentration (MIC) values of 76 imipenem nonsusceptible A. baumannii strains, isolated from a tertiary care hospital, were determined by microdilution method. The clonal relationship of the isolates was analyzed with enterobacterial repetitive intergenic consensus (ERIC)-PCR, and the presence of CHO major groups (OXA-23; OXA-24, OXA-51, and OXA-58 groups) was investigated with multiplex …

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Reply To Letter To The Editor, Ju Tae Sohn Jan 2017

Reply To Letter To The Editor, Ju Tae Sohn

Turkish Journal of Medical Sciences

No abstract provided.

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Lack Of Mir143, Mir145, Mir184, Mir1224, And Mir29b1 Mutations In Keratoconus Pathogenesis, Nurullah Çağil, Nagi̇han Uğurlu, Cemi̇l Yunus Şahan, Serhat Sevli̇ Jan 2017

Lack Of Mir143, Mir145, Mir184, Mir1224, And Mir29b1 Mutations In Keratoconus Pathogenesis, Nurullah Çağil, Nagi̇han Uğurlu, Cemi̇l Yunus Şahan, Serhat Sevli̇

Turkish Journal of Medical Sciences

No abstract provided.

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Superiorly Based Nasolabial Island Flap For Reconstruction Of The Lateral Lower Eyelid, Sedat Tatar, Yalçin Yontar, Selahatti̇n Özmen Jan 2017

Superiorly Based Nasolabial Island Flap For Reconstruction Of The Lateral Lower Eyelid, Sedat Tatar, Yalçin Yontar, Selahatti̇n Özmen

Turkish Journal of Medical Sciences

Background/aim: Various flap procedures have been described and used for the lower eyelids; however, the nasolabial flap is rarely employed. We herein aimed to present the clinical results of using the superiorly based nasolabial island flap for repair of surgical defects extending to the lateral lower eyelid. Materials and methods: Nine patients with a mean age of 62 +- 6 years underwent surgery for reconstruction of the lower eyelid.Results: The diagnosis of lesions was nodular basal-cell carcinoma (n = 5), superficial basal-cell carcinoma (n = 1), well-differentiated squamous-cell carcinoma (n = 1), and basosquamous-cell carcinoma (n = 2). According to …

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Plasma Urotensin Ii Levels In Primary Raynaud's Phenomenon And Systemic Sclerosis, Nevzat Gözel, Ahmet Karataş, Meltem Yardim, Mesude Seda Aydoğdu, Ramazan Ulu, Fati̇h Demi̇rcan, Faruk Kilinç, Burak Öz, Emi̇r Dönder, Süleyman Aydin, Süleyman Serdar Koca Jan 2017

Plasma Urotensin Ii Levels In Primary Raynaud's Phenomenon And Systemic Sclerosis, Nevzat Gözel, Ahmet Karataş, Meltem Yardim, Mesude Seda Aydoğdu, Ramazan Ulu, Fati̇h Demi̇rcan, Faruk Kilinç, Burak Öz, Emi̇r Dönder, Süleyman Aydin, Süleyman Serdar Koca

Turkish Journal of Medical Sciences

Background/aim: The pathogenesis of Raynaud's phenomenon (RP) has not yet been fully elucidated. RP is characterized by exaggerated cold-induced vasoconstriction. Urotensin II (UII) is a potent vasoconstrictor. The aim of the present study was to evaluate plasma UII levels in both primary RP and secondary RP associated with systemic sclerosis (SSc).Materials and methods: Fifteen patients with primary RP, 30 patients with RP secondary to SSc, and 30 healthy controls (HC) were included in the study. Raynaud condition scores (RCS) were determined in the primary RP and SSc groups. Modified Rodnan skin score (MRSS) was determined for the SSc patients. Plasma …

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An Examination Of Healthcare-Associated Infections In Elderly Patients, Serap İskender, Gürdal Yilmaz, İftahar Köksal Jan 2017

An Examination Of Healthcare-Associated Infections In Elderly Patients, Serap İskender, Gürdal Yilmaz, İftahar Köksal

Turkish Journal of Medical Sciences

Background/aim: Healthcare-associated infections (HCAIs) are increasing due to the growing numbers of elderly people requiring long-term care and immunosuppressive therapies. The purpose of this study was to examine HCAIs occurring in elderly inpatients in our hospital.Materials and methods: This study prospectively investigated HCAIs developing in all patients hospitalized over a 1-year period. Diagnosis was based on Centers for Disease Control criteria. The results were subjected to statistical analysis between patients aged over and under 65.Results: A total of 24,692 patients were evaluated and 894 HCAIs were identified. Of these infections, 214 were seen in patients aged 65 or over. The …

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Prediction Of Central Lymph Node Metastasis In Patientswith Thyroid Papillary Microcarcinoma, Şafak Akin, Duygu Yazgan Aksoy, Serkan Akin, Mehmet Kiliç, Fahri̇ Yeti̇şi̇r, Mi̇yase Bayraktar Jan 2017

Prediction Of Central Lymph Node Metastasis In Patientswith Thyroid Papillary Microcarcinoma, Şafak Akin, Duygu Yazgan Aksoy, Serkan Akin, Mehmet Kiliç, Fahri̇ Yeti̇şi̇r, Mi̇yase Bayraktar

Turkish Journal of Medical Sciences

Background/aim: The purpose of this study was to analyze the clinicopathological characteristics of patients with papillary thyroid carcinoma (PTC) and papillary thyroid microcarcinoma (PTMC) and predictive factors for central lymph node metastasis (CLNM).Materials and methods: Patients diagnosed as having PTC and PTMC were evaluated. Clinical and laboratory parameters were recorded.Results: The mean age at diagnosis was 47.3 +- 11.9 years. Of all 223 patients, 91 (40.8%) had lymph nodes removed, 29 of whom had lymph node metastasis and 24 of whom had only CLNM. Univariate analysis revealed that central lymph node metastasis was associated with male sex, presence of bilaterality, …

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The Efficacy Of In Situ Local Autograft In Adolescent Idiopathic Scoliosis Surgery: A Comparison Of Three Different Grafting Methods, Meti̇n Işik, Haci Mustafa Özdemi̇r, Abdurrahman Sakaoğullari, Bertan Cengi̇z, Nevres Hürri̇yet Aydoğan Jan 2017

The Efficacy Of In Situ Local Autograft In Adolescent Idiopathic Scoliosis Surgery: A Comparison Of Three Different Grafting Methods, Meti̇n Işik, Haci Mustafa Özdemi̇r, Abdurrahman Sakaoğullari, Bertan Cengi̇z, Nevres Hürri̇yet Aydoğan

Turkish Journal of Medical Sciences

Background/aim: This study was performed to show the efficacy of in situ local autograft with a comparison of in situ local autograft, local autograft with allograft, and local autograft with posterior iliac crest autograft.Materials and methods: In this prospective randomized study, a total of 65 adolescent idiopathic scoliosis (AIS) patients were separated into 3 groups: Group 1 using local autograft and allograft, Group 2 using local autograft only, and Group 3 using local autograft and posterior iliac crest autograft. Posterior segmental instrumentation was also applied to all patients. The mean follow-up period was 28.5 months (range, 15-40 months). Pseudarthrosis was …

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Evaluation Of Ambulatory Arterial Stiffness Index In Hyperthyroidism, Özlem Turhan İyi̇di̇r, Mehmet Muhi̇tti̇n Yalçin, Alev Eroğlu Altinova, İsmai̇l Emre Arslan, Bahar Uncu Ulu, Ceyla Konca Değerteki̇n, Füsun Saadet Törüner Jan 2017

Evaluation Of Ambulatory Arterial Stiffness Index In Hyperthyroidism, Özlem Turhan İyi̇di̇r, Mehmet Muhi̇tti̇n Yalçin, Alev Eroğlu Altinova, İsmai̇l Emre Arslan, Bahar Uncu Ulu, Ceyla Konca Değerteki̇n, Füsun Saadet Törüner

Turkish Journal of Medical Sciences

Background/aim: Hyperthyroidism causes hemodynamic changes that are associated with adverse cardiovascular outcomes. Twenty-four-hour ambulatory blood pressure monitoring recordings provide us with some essential data: BP variability and ambulatory arterial stiffness index (AASI). In this study, we aimed to investigate AASI and short-term BP variability in both overt and subclinical hyperthyroidism and their relationship with thyroid hormones. Materials and methods: We enrolled 36 patients with subclinical hyperthyroidism, 23 patients with overt hyperthyroidism, and 25 healthy euthyroid controls. ABPM recording was performed for 24 h for all patients. Results: There were no statistically significant differences among the overt hyperthyroidism, subclinical hyperthyroidism, and …

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Expression Profiles Of Cd11b, Galectin-1, Beclin-1, And Caspase-3 In Nasal Polyposis, Alper Di̇lci̇, Nuray Varol, İlker Kiliçcioğlu, Ece Konac, Utku Aydi̇l, Yusuf Kizil, Süleyman Sabri̇ Uslu Jan 2017

Expression Profiles Of Cd11b, Galectin-1, Beclin-1, And Caspase-3 In Nasal Polyposis, Alper Di̇lci̇, Nuray Varol, İlker Kiliçcioğlu, Ece Konac, Utku Aydi̇l, Yusuf Kizil, Süleyman Sabri̇ Uslu

Turkish Journal of Medical Sciences

Background/aim: Nasal polyposis is a chronic inflammatory disease affecting the paranasal sinuses and nasal mucosae. It is thought that genetic and molecular mechanisms in inflammatory and apoptotic pathways are the main factors in the etiopathogenesis of nasal polyposis. The aim of this study was to investigate the expression patterns of CD11b, galectin-1, beclin-1, and caspase-3 in nasal polyps.Materials and methods: The mRNA expression levels of CD11b, galectin-1, beclin-1, and caspase-3 protein and western blot analysis of caspase-3 protein were evaluated in inferior turbinate mucosae and nasal polyp tissues.Results: CD11b expression was markedly higher in nasal polyp tissues when compared to …

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Pediatric Emergency Care Applied Research Network Head Injuryprediction Rules: On The Basis Of Cost And Effectiveness, Fatma Di̇lek Gökharman, Sonay Aydin, Erdem Fati̇hoğlu, Pinar Nerci̇s Koşar Jan 2017

Pediatric Emergency Care Applied Research Network Head Injuryprediction Rules: On The Basis Of Cost And Effectiveness, Fatma Di̇lek Gökharman, Sonay Aydin, Erdem Fati̇hoğlu, Pinar Nerci̇s Koşar

Turkish Journal of Medical Sciences

Background/aim: Head injuries are commonly seen in the pediatric population. Noncontrast enhanced cranial CT is the method of choice to detect possible traumatic brain injury (TBI). Concerns about ionizing radiation exposure make the evaluation more challenging. The aim of this study was to evaluate the effectiveness of the Pediatric Emergency Care Applied Research Network (PECARN) rules in predicting clinically important TBI and to determine the amount of medical resource waste and unnecessary radiation exposure.Materials and methods: This retrospective study included 1041 pediatric patients presented to the emergency department. The patients were divided into subgroups of "appropriate for cranial CT", "not …

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Comparing The Effectiveness Of Ultrasound-Guided Versus Blind Steroid Injection In The Treatment Of Severe Carpal Tunnel Syndrome, Özgür Zeli̇ha Karaahmet, Eda Gürçay, Murat Kara, Azi̇ze Serçe, Zeynep Kiraç Ünal, Fatma Aytül Çakci Jan 2017

Comparing The Effectiveness Of Ultrasound-Guided Versus Blind Steroid Injection In The Treatment Of Severe Carpal Tunnel Syndrome, Özgür Zeli̇ha Karaahmet, Eda Gürçay, Murat Kara, Azi̇ze Serçe, Zeynep Kiraç Ünal, Fatma Aytül Çakci

Turkish Journal of Medical Sciences

Background/aim: This study aimed to compare the effectiveness of ultrasound (US)-guided injection versus blind injection of corticosteroids in the treatment of carpal tunnel syndrome (CTS). Materials and methods: This prospective, randomized clinical trial included patients with severe CTS based on clinical and electrophysiological criteria. The patients were evaluated for clinical and electrophysiological parameters at baseline and 4 weeks after treatment. Symptom severity and hand function were assessed by the Boston questionnaire. The patients underwent blind injection or US-guided injection. Results: When compared with baseline, both groups showed significant improvement in Boston questionnaire scores and all electrophysiological parameters. Significant differences were …

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Concordance Of Immunohistochemistry Between Core Needle Biopsy And Surgical Resection Of Breast Cancer, Faruk Erdem Kombak, Hülya Şahi̇n, Hande Mollamemi̇şoğlu, İdri̇s Önem, Handan Kaya, Onur Buğdayci, Mustafa Erki̇n Aribal Jan 2017

Concordance Of Immunohistochemistry Between Core Needle Biopsy And Surgical Resection Of Breast Cancer, Faruk Erdem Kombak, Hülya Şahi̇n, Hande Mollamemi̇şoğlu, İdri̇s Önem, Handan Kaya, Onur Buğdayci, Mustafa Erki̇n Aribal

Turkish Journal of Medical Sciences

Background/aim: The purpose of this study was to evaluate the concordance of immunohistochemical (IHC) parameters of breast lesions between the core needle biopsy (CNB) and the surgical resection specimen. Materials and methods: CNB and resection specimens of female patients were retrospectively analyzed. ER, PR, HER-2, and Ki-67 parameters were compared for each patient. A total of 284 cases were assessed. Forty-one and 48 cases were excluded from the HER-2 and Ki-67 examinations, respectively, because the CNBs did not allow for IHC. Results: Concordance rates were 93.3% for ER, 89.4% for PR, 90.1% for HER-2, and 80.9% for Ki-67.Conclusion: CNB is …

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The Relationship Between The Trendelenburg Position And Cerebral Hypoxia Inpatients Who Have Undergone Robot-Assisted Hysterectomy And Prostatectomy, Ali̇ Özgün, Asuman Sargin, Semra Karaman, İlkben Günüşen, Işik Alper, Fatma Zeki̇ye Aşkar Jan 2017

The Relationship Between The Trendelenburg Position And Cerebral Hypoxia Inpatients Who Have Undergone Robot-Assisted Hysterectomy And Prostatectomy, Ali̇ Özgün, Asuman Sargin, Semra Karaman, İlkben Günüşen, Işik Alper, Fatma Zeki̇ye Aşkar

Turkish Journal of Medical Sciences

Background/aim: This study aimed to evaluate the relationship between the Trendelenburg position and cerebral hypoxia in robot-assisted hysterectomy and prostatectomy.Materials and methods: A standardized mini-mental state examination was administered to 50 patients enrolled in the study 1 h before and after surgery. Near infrared spectroscopy (NIRS) values and hemodynamic and respiratory parameters were recorded after induction of anesthesia (baseline) and once every 20 min in the Trendelenburg position and supine positions. The relationship between the development of cerebral desaturation and the patient's position was examined. Results: For all patients, the baseline mean cerebral oxygen saturation (RSO2) on the right and …

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Tnf-Alpha 863c > A Promoter And Tnfrii 196t > G Exonic Variationsmay Be Risk Factors For Juvenile Idiopathic Arthritis, Bahadir Batar, Sezen Özman, Kenan Barut, Özgür Kasapçopur, Mehmet Güven Jan 2017

Tnf-Alpha 863c > A Promoter And Tnfrii 196t > G Exonic Variationsmay Be Risk Factors For Juvenile Idiopathic Arthritis, Bahadir Batar, Sezen Özman, Kenan Barut, Özgür Kasapçopur, Mehmet Güven

Turkish Journal of Medical Sciences

Background/aim: Juvenile idiopathic arthritis (JIA) is a chronic complex autoimmune disease. Genetic and environmental factors increase the risk of JIA. It is accepted that alterations in immune system pathways play an important role in the pathogenesis of JIA. The aim of the study was to investigate the possible association between immune system regulatory gene polymorphisms and JIA in Turkish patients. Materials and methods: We analyzed eight polymorphisms, TNF-alpha-863 C > A, TNFRII 196 T > G, IL2-631 G > A, IL13-1112 C > T, CCR2 190 G > A, CCR5delta32, CTLA4-1661 A > G, and PTPN22 1858 C > T, in 76 patients with JIA and in …

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Turkish Version Of The Motor Function Measure Scale (Mfm-32) Forneuromuscular Diseases: A Cross-Cultural Adaptation, Reliability, And Validity Study, Habi̇be Serap İnal, Ela Tarakçi, Devri̇m Tarakçi, Gülcan Aksoy, Sezan Mergen Kiliç, Hakan Beşer, Çi̇ğdem Beşer, Arzu Razak Özdi̇nçler, Hacer Durmuş Tekçe, Fatma Yeşi̇m Parman, Feza Deymeer, Zehra Pi̇raye Oflazer Jan 2017

Turkish Version Of The Motor Function Measure Scale (Mfm-32) Forneuromuscular Diseases: A Cross-Cultural Adaptation, Reliability, And Validity Study, Habi̇be Serap İnal, Ela Tarakçi, Devri̇m Tarakçi, Gülcan Aksoy, Sezan Mergen Kiliç, Hakan Beşer, Çi̇ğdem Beşer, Arzu Razak Özdi̇nçler, Hacer Durmuş Tekçe, Fatma Yeşi̇m Parman, Feza Deymeer, Zehra Pi̇raye Oflazer

Turkish Journal of Medical Sciences

Background/aim: The Motor Function Measure (MFM-32) is a classification system for ambulant and nonambulant patients with neuromuscular diseases (NMDs). We aimed to translate it into Turkish, culturally adapt it, and test its reliability and validity for Turkish patients with NMDs.Materials and methods: The translation of the 32 items assessing three functional areas: standing position and transfers (D1: 13), axial/proximal (D2: 12), and distal (D3: 7) motor functions was performed according to the established guidelines for cross-cultural adaptation. Totally 51 patients (12.56 ± 8.84 years; F/M 12/39) were tested. Vignos and Brooke scores for the lower and upper extremities, respectively, were …

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Association Between Deep Neck Space Abscesses And Internal Carotid Artery Narrowing In Pediatric Patients, Betül Emi̇ne Deri̇nkuyu, Öznur Boyunağa, Meltem Polat, Çağri Damar, Anil Tapisiz, Ayşe Gül Alimli, Çi̇ğdem Öztunali, Soner Sertan Kara, Murat Uçar, Hasan Tezer Jan 2017

Association Between Deep Neck Space Abscesses And Internal Carotid Artery Narrowing In Pediatric Patients, Betül Emi̇ne Deri̇nkuyu, Öznur Boyunağa, Meltem Polat, Çağri Damar, Anil Tapisiz, Ayşe Gül Alimli, Çi̇ğdem Öztunali, Soner Sertan Kara, Murat Uçar, Hasan Tezer

Turkish Journal of Medical Sciences

Background/aim: Our aim was to interpret the effects of deep neck space abscesses on the adjacent carotid artery according to abscess location, as well as to determine narrowing by calculating the mean stenosis ratios.Materials and methods: Neck computed tomography scans and clinical data of 45 children with neck abscesses were evaluated retrospectively for abscess location and internal carotid artery narrowing. The lumen areas of the carotid arteries were measured from standard levels, and stenosis ratios were calculated with two different techniques. The mean stenosis ratios of each group according to abscess location were then compared with the control group.Results: Among …

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