Medicine and Health Sciences Commons^™

Enhancing Childrens Social-Emotional Learning Skills Through Mindfulness Practices, Shun Yi Wan, Stephanie Chang, Jordan Fenlon, Amrith Shettigar, Mckenzie Johnson, Sam Lealofi

Research Day

Background: The Kalamazoo Eastside neighborhood has been subject to a great deal of economic and functional instability, particularly impacting the youth. Local demographic studies indicate that 90% of children are eligible for free or reduced lunch due to low income, 58% of households are single-female households, and 29% of parents do not have a high school diploma. Eastside Youth Strong (EYS) is a local organization focused on improving the lives of these children. This study will be investigating the EYS afterschool program’s mindfulness initiative. Purpose: Social and emotional learning were chosen to be studied because these skills are critical for …

Delivery Of Health Education In Adolescents With Behavioral Health Challenges, Ashley Akkal, Ransome Eke Md, Phd, Sulin Wu, Amy Rechenberg, Michael Madrid, Jose Lopez-Vera, Duncan Vos

Research Day

BACKGROUND Adolescents with behavioral health issues tend to have inadequate access to health education, and are thus less aware of the importance of personal and dental hygiene, exercise, and healthy diet and lifestyle habits. Due to this disparity, this population has been known to harbor a higher prevalence of STI’s, drug and alcohol abuse, physical altercations, juvenile detention, and suicide attempts. PURPOSE The overall objective of this study was to examine the effect of integrating a health science curriculum in this population. METHODS Participants aged 5-17 years old were recruited and assigned to either control or science groups by Family …

A Case Of Native Valve Staphylococcus Epidermidis Endocarditis With Cardiac Abscess Formation, Emily Cordes, Chris Jacob, Mark Loehrke

Research Day

Introduction: Staphylococcus epidermidis is the most common commensal bacteria of the skin; however it can be pathogenic and is the most frequent cause of medical device associated endocarditis. It is also a well-known cause of endocarditis in IV drug abuse (IVDA). However, in individuals without obvious disruption of the skin barrier, it is a relatively rare, but emerging entity of native valve endocarditis. Coagulase negative staphylococci account for only 1-5% of community acquired native valve infective endocarditis and most resolve with treatment. We report a case of a 56 year old male with an aggressive strain of community acquired Staphylococcus …

Challenges In The Diagnosis And Management Of Pediatric Pulmonary Tuberculosis In Madagascar, Emily Cordes, Richard Roach

Research Day

Introduction: Tuberculosis (TB) remains an important cause of morbidity and mortality in Madagascar. According to the World Health Organization (WHO), in 2015, the estimated incidence of TB was 57,000 and 11,000 of those cases were of patients less than 14 years old. Of the reported cases, 89% were bacteriologically confirmed. However, it is well established that bacteriologic confirmation of TB in children is especially difficult. Therefore, the incidence of TB in the pediatric population in Madagascar, and likely worldwide, is under estimated. We report a case of a 4 year old male that illustrates the challenges in diagnosis and management …

Widening The Differential: A Case Of Hemophagocytic Lymphohistiocytosis Disguised As A Fever Of Unknown Origin, Emily Cordes

Research Day

Introduction: Hemophagocytic lymphohistiocytosis (HLH) is an under recognized, aggressive inflammatory disease characterized by excessive activity of histiocytes and lymphocytes. According to the HLH-2004 guidelines, five of the following eight criteria must be met to diagnose HLH: fever >38.5¡ã C, splenomegaly; cytopenias affecting ¡Ý two cell lines; hypertriglyceridemia/hypofibrinogenemia; evidence of hemophagocytosis in the bone marrow, spleen or lymph nodes; hyperferritinemia; low NK cell activity; or high levels of soluble CD25. Once a diagnosis of HLH is established, investigations for infectious, malignant or autoimmune etiologies must be pursued. We report a case of fever of unknown origin (FUO) that presented multiple times …

Social Determinants - Impacting Or Causing Disparities In Patient Care?, Shaena Faye Freeman Md, Kristi Vanderkolk Md

Research Day

Health disparities secondary to social factors including socioeconomic status, race, gender and ethnicity are well known to the health community and are a troubling issue in the United States. Social determinants are defined by the WHO as the structural “conditions people are born, live, grow, work and age in…determined by wealth distribution and available resources…that are mostly responsible for health inequalities.” We present here the case of TL, a 49 year old African American female who presented to the emergency department three times with atypical coronary disease symptoms in the setting of recent NSTEMI with subsequent 3 vessel CABG. At …

Cryptococcal Empyema: A Rare Manifestation Of Disease, Mohamed Mortagy, Larry Lutwick, Stephen Breisach

Research Day

Introduction: Cryptococcus neoformans is a pathogenic yeast that is generally acquired by man from the environment via the respiratory route. Despite this route of acquisition, overt pulmonary infection is uncommonly diagnosed and the disease is usually manifest as a subacute meningitis which is mostly manifest in individuals who are celluarly immunoincompetent such as those on cancer chemotherapy, receiving anti-solid organ rejection medications and those with HIV/AIDS. Infection of the pleural space with C. neoformans is quite uncommon. We report a non-immunosuppressed man who was found to have infection of the pleural in the wake of bacterial empyema who was successfully …

Infection-Associated Mycobacterium Fortuitum Infection, Dennis T. Huang, Larry Lutwick

Research Day

Introduction: Mycobacterial species are unusual causes of skin and soft tissue infections and can be difficult to diagnose in the absence of consideration as they often require specific culture media and longer incubation times. We report a Mycobacterium fortuitum subcutaneous abscess in a diabetic related to medication injection that was initially diagnosed without specialized media or prolonged incubation times. Case Report: A 48 year old diabetic female developed a progressive subcutaneous swelling in the tissues of the right lower abdominal wall where she had been injecting liraglutide. Because of continued enlargement "to almost egg size" with pain, she was empirically …

Acute Hypoxic Respiratory Failure As A Complication Of A Urinary Tract Infection During Pregnancy: A Case Presentation, Manpreet S. Narwal, Susan Jevert-Eichorn, Narinder Nina Clair

Research Day

Urinary tract infections (UTI), as well as asymptomatic bacteriuria, have the potential to cause serious morbidity during pregnancy making it imperative to identify and treat them promptly. If left untreated, a UTI can lead to pyelonephritis and sepsis. More importantly, UTIs are independently associated with intrauterine growth restriction (IUGR), premature rupture of membranes (PROM), preterm delivery, pulmonary edema, acute respiratory distress syndrome (ARDS), preeclampsia, and cesarean delivery. We report the case of NC, a 19 year old G1P0 at 36 weeks and 3 days GA who presented to the hospital with concern for rupture of membranes with associated back and …

Determining Best Practices Of Peer Mediation Methods In Kalamazoo Public Schools, Melanie Bourgeau, Dagan Hammar, Neil Hughes, Sarah Kemp, Sydney Spitler, Cathy L. Kothari Phd

Research Day

Determining Best Practices of Peer Mediation methods in Kalamazoo Public Schools Melanie Bourgeau, Dagan Hammar, Neil Hughes, Sarah Kemp, Sydney Spitler, Catherine Kothari BACKGROUND Peer mediation is a method of conflict resolution in which a conflict between two people or groups is guided by a fellow student in order to reach an agreement. Peer mediation has been shown to be an effective tool in helping students resolve conflict and how to respond to future conflicts. This has led to a reduction in school violence and suspensions in schools that have adopted this method. Several methods have been employed in the …

A Review Of Transcatheter Ablation For The Treatment Of Avnrt In Children, Keegan Colletier, Sulin Wu, Stephanie Van Alsten, Brittany Chow

Research Day

Background: Atrioventricular nodal reentrant tachycardia (AVNRT) is an arrhythmia due to re-entrant rhythm within the region of the atrioventricular (AV) node, which accounts for most supraventricular tachycardia (SVT) cases in children. There are two main pathways involved for the re-entrant rhythm, slow and fast pathways, with different anatomic locations and involvement in the circuit associated with AVNRT. AVNRT is rare in newborns, but an increase of prevalence throughout childhood was previously reported.Study Objective/Purpose: Currently, Radiofrequency (RF) ablation is the primary method for the treatment of AVNRT in pediatrics. However, multiple modalities with varying efficacies can also be utilized. In this …

Considerations For Prep Introduction To Adolescent Girls And Young Women: Implementation Science Research In Tanzania, Population Council

HIV and AIDS

In collaboration with the National AIDS Control Programme and CSK Research Solutions Ltd., a Tanzania-based research organization, the Population Council is conducting implementation science research in Tanzania to build needed evidence to inform decisionmaking around the introduction of oral pre-exposure prophylaxis (PrEP) to adolescent girls and young women (AGYW), ages 15–24. This research will actively engage key stakeholders throughout the study, including gaining their insights on key study questions, interpreting the findings, crafting initial programming recommendations based on findings, and supporting their adoption in Tanzania and beyond. Findings from this study and other observational studies and demonstration trials in progress …

Parents' And Guardians' Perceptions Of Oral Pre-Exposure Prophylaxis Introduction In Tanzania: Findings From Implementation Science Research, Population Council

HIV and AIDS

The Population Council, in collaboration with the National AIDS Control Programme (NACP) and CSK Research Solutions Ltd., conducted implementation science research in two research sites in Tanzania to identify key considerations for introducing oral pre-exposure prophylaxis (PrEP) to adolescent girls and young women (AGYW). The NACP and members of the study’s research utilization committee recognized the importance of learning about parents’ and guardians’ attitudes and perceptions of PrEP use by their adolescent and young adult daughters and peers to inform the PrEP implementation process in Tanzania. Moreover, existing research in Tanzania finds that parents communicate with their children about sexual …

Patent: Nestorone®/Estradiol Transdermal Gel, Régine Sitruk-Ware, Dario Norberto Ramon Carrara, Arnaud Grenier

Formulation/Product Development

The invention discloses compositions and methods for ensuring in both women of fertile age where it ensures also a contraception with additional health benefits and in postmenopausal women where it offers a hormonal therapy with additional medical benefits such as the potential for lower risk of thrombosis. The compositions comprising NES as a potent progestational and antiovulatory agent with no androgenic nor estrogenic nor glucocorticoid effect, and combined with estradiol formulated for non-oral transdermal administration as specific daily doses.

Bsn Students’ Satisfaction And Self-Confidence In Simulation-Based Learning, Aubrey Winum

Undergraduate Honors Theses

As nurse educators prepare students to enter the real world, they are challenged to create learning methods that develop confident and competent nurses. While new graduate nurses have much to learn, they are expected to be able to work as a team, think critically, and provide a safe environment for patients. A nursing program at a small, liberal arts college in the Foothills of the Blue Ridge Mountains utilized simulation-based learning experiences to prepare students for the many situations they may face as a future nurse. The purpose of this study was to evaluate the impact these experiences had on …

Prediction And Benefits Of Minimal Disease Activity In Patients With Psoriatic Arthritis And Active Skin Disease In The Adept Trial., Philip Mease, Arthur Kavanaugh, Laura C Coates, Iain B Mcinnes, Maja Hojnik, Ying Zhang, Jaclyn K Anderson, Alexander P Dorr, Dafna D Gladman

Articles, Abstracts, and Reports

Objectives: To determine the proportion of patients with psoriatic arthritis in the Adalimumab Effectiveness in Psoriatic Arthritis trial achieving minimal disease activity (MDA) and its individual components at 1 or more visits over 144 weeks, identify baseline predictors of MDA achievement, and evaluate the association of MDA status with independent quality of life (QoL)-related patient-reported outcomes (PROs).

Methods: Univariate and multivariate analyses were used to identify the baseline characteristics that predicted achievement of MDA at individual time points (weeks 12 through 144) or sustained MDA (achievement of MDA at 2 consecutive time points 12 weeks apart). The association of independent …

The Effect Of Road Noise On Sound Pressure Levels And Preferred Listening Levels Using Personal Listening Devices, Hayley Himstedt

Doctoral Dissertations

Using a PLD in an automobile introduces unique threats such as volume levels set at higher levels to reduce the masking effects of road noise that enters the automobile. Passengers enjoying prolonged PLD exposure may be at an increased risk of noise exposure or fluctuating sound pressure levels resulting in hearing loss. Historically, hazardous noise has been primarily associated with industrial/occupational activities; however, harmful noise from recreational activities is also prevalent. The Center for Disease Control (2015) lists turning down PLD volume as one of their top three methods for reducing the possibility of NIHL in children. Excessive listening level …

Efficacy Of Elder Support And Education On Measles Vaccination Rates In Amish Communities, Amber Porter, Alfaro Mariateresa, Lan Marietta, Kristen Schriver, Michelle Douglas, Bonnie Lozy, Emily Burgos

OUR Journal: ODU Undergraduate Research Journal

Background: Proposed study within Amish community to increase measles vaccinations and education about measles: etiology and transmission, aseptic techniques, and quarantine/isolation.

Significance: The majority of Amish people are unvaccinated. Massive outbreaks of measles (363 cases in Ohio) within Amish communities.

Method: Non-random, convenience sampling of participants in two Amish communities: Indiana and Illinois.

Analysis: Closed-ended questions with nominal data. Biological measurements with integral data. Qualitative analysis, chi square and statistical analysis used to determine outcome and results.

Drug Court Versus Incarceration: Which Is More Effective?, Erin Alexander, Kathryn Apperson, Megan Flannigan, Sarah Jean, Lintag Rosalina, Jennifer Lynch, Ethan Schwartz

OUR Journal: ODU Undergraduate Research Journal

Aim: This study explores the affect drug court treatment programs have on the sobriety and employment status of the participants.

Background: Drug addiction has been an ongoing issue nationwide, and with addiction comes drug related crimes. Currently the preferred solution to this epidemic is to impose longer and longer lengths of incarceration for every incurred infraction. Methods: A descriptive correlational design will be used for this research study to evaluate the effectiveness of drug court compared to incarceration. The participants will be chosen by a random sampling of 100 residents of the Hampton Roads area of Virginia--50 …

Effects Of Peer Support Group On Rates Of Suicide Attempts, Suicidal Thoughts, And Incidences Of Self-Harm For Sexual-Minority High School Students, Samantha Fleming, Rebecca O'Neill, Allyson Jett, Haley Mann, Ashlee Peters, Deja Dixon

OUR Journal: ODU Undergraduate Research Journal

The torment sexual minority youth experience can take a psychological toll without access to a support system. The purpose of this proposal is to determine whether an after-school peer support group for sexual minority youth could decrease incidences of suicidal thoughts, attempts, and/or self-inflicted injuries.

The Effect Of An Interprofessional Registered Nurse-Physical Therapist Team On Reducing Prescribed Opioid Dependence In Patients With Chronic Lower Back Pain, Amber Chesney, Stephanie Jan, Amanda Pedrazoli, Brandon Simmons, Kaylene Woods, Nicole Yeats

OUR Journal: ODU Undergraduate Research Journal

Long-term prescribed opioid use for chronic pain is shown to reduce recovery potential and increase risk for dependence, which is contributing to the nationwide opioid crisis. There is a need for an innovative, multidisciplinary approach to address prescription opioid dependence. We propose implementation of a community-based interprofessional registered nurse-physical therapist team (IRNPTT) focused on reduction of opioid dependence in adult patients with chronic lower back pain.

2017 Apothecary, Southwestern Oklahoma State University

Apothecary

This publication is dedicated to the Southwestern College of Pharmacy faculty, staff, alumni, and students. We congratulate this year's graduating seniors and wish you success in your professional careers.

It is with great honor we present the 2017 Apothecary issue. This year's Apothecary was made possible by the provision of generous financial contributions from many stores, businesses, and Southwestern College of Pharmacy alumni. We greatly appreciate and thank you for your continued support.

The Effect Of Health Care Entrepreneurship On Local Health: The Case Of Medexpress In Appalachia, Amir B. Neto, Joshua C. Hall

Economics Faculty Working Papers Series

We test the hypothesis that the opening of an Urgent Care Center (UCC) has positive impacts on the local community. There are several mechanisms through which a UCC can have an impact: lower health care costs, emergency room decongestion, and improved access to medical information. We examine the entry of MedExpress into Appalachian counties between 2001 and 2013. Employing data from Health Resources Files, which provides information for all counties for specific years, we use Propensity Score Matching to create a year 2000 control group for the counties “treated” by MedExpress entry beginning in 2001. We then employ a standard …

Bis(N-Amidinohydrazones) And N-(Amidino)-N'-Aryl-Bishydrazones: New Classes Of Antibacterial/Antifungal Agents, Sanjib K. Shrestha, Liliia M. Kril, Keith D. Green, Stefan Kwiatkowski, Vitaliy M. Sviripa, Justin Robert Nickell, Linda Phyliss Dwoskin, David S. Watt, Sylvie Garneau-Tsodikova

Pharmaceutical Sciences Faculty Publications

The emergence of multidrug-resistant bacterial and fungal strains poses a threat to human health that requires the design and synthesis of new classes of antimicr obial agents. We evaluated bis(N-amidinohydrazones) and N-(amidino)-N'-aryl-bishydrazones for their antibacterial and antifungal activities against panels of Gram-positive/Gram-negative bacteria as well as fungi. We investigated their potential to develop resistance against both bacteria and fungi by a multi-step, resistance-selection method, explored their potential to induce the production of reactive oxygen species, and assessed their toxicity. In summary, we found that these compounds exhibited broad-spectrum antibacterial and antifungal activities against most of …

Expanding Access To Integrated Family Planning Intervention Packages For Married Adolescent Girls In Urban Slums Of Dhaka, Bangladesh, Fauzia Akhter Huda, Hassan Rushekh Mahmood, Sadia Afrin, Anisuddin Ahmed, Nafis Al Haque, Bidhan Krishna Sarker

Reproductive Health

This research report describes an intervention study conducted among married adolescent girls aged 15–19 years in four urban slums of Dhaka, Bangladesh. Objectives of the study were to examine the acceptability and feasibility of forming married adolescent girls’ clubs, and involving community health volunteers (Shasthya Skebikas) and marriage registrars to increase access to family planning (FP) information and services, to promote the uptake of long-acting reversible contraceptive methods, and to provide FP information to newlywed couples at the time of marriage registration. The study findings revealed that a noteworthy number of married adolescent girls received FP-related information, mostly from the …

Creating A Culture Of Evidence Use: Using An Innovative Knowledge Translation Platform To Inform Hiv/Aids Programming For Women And Girls, Jill Gay, Melanie Croce-Galis, Karen Hardee, Amelia Peltz

Reproductive Health

Given that moving evidence from a study to policy, programs, and practice can often take a decade or more, what is the best way to get evidence into the hands of those developing policies and programs to speed its use? Enhancing the use of evidence in policies and programs through an innovative web-based knowledge platform, What Works for Women: Evidence for HIV/AIDS Interventions, resulted in major changes in National Strategic HIV Plans plus Concept Notes submitted to the Global Fund to Fight AIDS, Tuberculosis and Malaria in 14 countries in Africa, Asia, and Latin America. This paper documents how components …

Status Of Sexual And Reproductive Health And Rights In Zambia: Contraception And Family Planning, Preventing Unsafe Abortion And Accessing Post Abortion Care, And Maternal Health, Population Council

Reproductive Health

In 1994, the International Conference on Population and Development affirmed that sexual and reproductive health and rights (SRHR) are human rights. The Government of the Republic of Zambia has fully committed to fulfilling the SRHR of all people by ratifying 11 international instruments of law. This brief is Part 1 of a three-part series entitled “Status of Sexual and Reproductive Health and Rights in Zambia,” reporting on progress, gaps, and existing challenges in SRHR. Using a human rights–based approach, the Government of Zambia and collaborators, with technical facilitation by the Population Council, conducted an assessment of the status of SRHR …

Substituent Strength Vs Reactivity: A Study Of 1,3,4-Oxadiazoles And Electron Donating Groups, Katlynn Merringer

Undergraduate Honors Thesis Projects

This investigation focused on determining if there was a relationship between electron donating group substituent strength and resulting percent yield values of the 1,3,4-oxadiazole product. The data obtained from this investigation aimed to help chemists better understand the reactivity of the 1,3,4-oxadiazole because of its importance in the realm of drug design and development. In order to accomplish this, electron donating groups with varying pKa values were placed on the 1,3,4-oxadiazole and the resulting percent yields were analyzed for possible trends. The substituents used represented both resonance donating and inductively donating groups and were placed in both ortho and para …

Synthesis Of Oxadeazoles With Electron Withdrawing Groups And The Analysis Of Product Yield With Bond Length, Elizabeth Ann Hall Peters

Undergraduate Honors Thesis Projects

2,5-disubstituted 1,3,4-oxadiazoles are a class of organic compound that are widely used and successful in pharmaceutical chemistry because they demonstrate strong biological activity. They are part of a larger class of compound called heterocycles, which make up most pharmaceutical drugs today. When synthesizing the compounds, higher yield means higher reactivity of the compound, and this is important for pharmaceuticals that need to have a strong biological activity. Per past studies, electron withdrawing groups on the compound allow higher, product yields. Along with electron withdrawing group addition, the bond length from electron withdrawing group and its corresponding carbon is analyzed to …

A Novel Design Of A Phase Iii Trial Of Isradipine In Early Parkinson Disease (Steady-Pd Iii), Kevin M. Biglan, David Oakes, Anthony E. Lang, Robert A. Hauser, Karen Hodgeman, Brittany Greco, Jillian Lowell, Rebecca Rockhill, Ira Shoulson, Charles Venuto, Diony Young, Tanya Simuni

Neurology Faculty Publications

Objectives To describe the rationale for a novel study design and baseline characteristics of a disease-modifying trial of isradipine 10 mg daily in early Parkinson disease (PD).

Methods STEADY-PDIII is a 36-month, Phase 3, parallel group, placebo-controlled study of the efficacy of isradipine 10 mg daily in 336 participants with early PD as measured by the change in the Unified Parkinson Disease Rating Scale (UPDRS) Part I-III score in the practically defined ON state. Secondary outcome measures include clinically meaningful measures of disability progression in early PD: (1) Time to initiation and utilization of dopaminergic therapy; (2) Time to onset …