Medicine and Health Sciences Commons^™

A Respiratory-Gated Micro-Ct Comparison Of Respiratory Patterns In Free-Breathing And Mechanically Ventilated Rats, Nancy L. Ford, Lynda Mccaig, Andrew Jeklin, James F. Lewis, Ruud A.W. Veldhuizen, David W. Holdsworth, Maria Drangova

Bone and Joint Institute

© 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society. In this study, we aim to quantify the differences in lung metrics measured in free-breathing and mechanically ventilated rodents using respiratory-gated micro-computed tomography. Healthy male Sprague-Dawley rats were anesthetized with ketamine/xylazine and scanned with a retrospective respiratory gating protocol on a GE Locus Ultra micro-CT scanner. Each animal was scanned while free-breathing, then intubated and mechanically ventilated (MV) and rescanned with a standard ventilation protocol (56 bpm, 8 mL/kg and PEEP of 5 cm H2O) and again with …

A Phosphorus-Rich Polymer As A Homogeneous Catalyst Scavenger, T. J. Cuthbert, E. Evoy, J. P.J. Bow, R. Guterman, J. M. Stubbs, E. R. Gillies, P. J. Ragogna, J. M. Blacquiere

Bone and Joint Institute

© The Royal Society of Chemistry 2017. A soft polymer network prepared through a phosphane-ene reaction successfully sequestered Rh and Ru from hydrogenation and ring closing metathesis reactions, respectively. Scavenging effectively quenches catalytic activity and ultimately removes >98% of the metal.

Efficacy Of Workplace Interventions For Shoulder Pain: A Systematic Review And Meta-Analysis, Véronique Lowry, Ariel Desjardins-Charbonneau, Jean Sébastien Roy, Clermont E. Dionne, Pierre Frémont, Joy C. Macdermid, François Desmeules

Bone and Joint Institute

© 2017 Foundation of Rehabilitation Information. Objective: To perform a systematic review and meta- analysis of randomized controlled trials on the efficacy of workplace-based interventions to prevent or treat shoulder pain. Data sources: A systematic review of 4 databases was performed up to January 2016. Study selection: Randomized controlled trials were included if the intervention under study was a workplace- based intervention performed to prevent or reduce shoulder pain and disability in workers. Data extraction: The methodological quality of the studies was evaluated and meta-analyses were conducted. Pooled mean differences and risk ratios were calculated. Data synthesis: Data from 4 …

Biomechanical Measurement Error Can Be Caused By Fujifilm Thickness: A Theoretical, Experimental, And Computational Analysis, Ahmed Sarwar, Simli Srivastava, Chris Chu, Alan Machin, Emil H. Schemitsch, Habiba Bougherara, Zahra S. Bagheri, Radovan Zdero

Bone and Joint Institute

© 2017 Ahmed Sarwar et al. This is the first study to quantify the measurement error due to the physical thickness of Fujifilm for several material combinations relevant to orthopaedics. Theoretical and experimental analyses were conducted for cylinder-on-flat indentation over a series of forces (750 and 3000 N), cylinder diameters (0 to 80 mm), and material combinations (metal-on-metal, MOM; metal-on-polymer, MOP; metal-on-bone, MOB). For the scenario without Fujifilm, classic Hertzian theory predicted the true line-type contact width as WO={(8FDcyl)/(πLcyl)[(1-cyl2)/Ecyl+(1-flat2)/Eflat]}1/2, where F is compressive force, Dcyl is cylinder diameter, Lcyl is cylinder length, cyl and flat are cylinder and flat Poisson's …

Delayed Endothelial Progenitor Cell Therapy Promotes Bone Defect Repair In A Clinically Relevant Rat Model, Brent D. Bates, Charles Godbout, David J. Ramnaraign, Emil H. Schemitsch, Aaron Nauth

Bone and Joint Institute

© 2017 Brent D. Bates et al. The repair of segmental bone defects remains a significant challenge for orthopaedic surgeons. Endothelial progenitor cells (EPCs) have successfully promoted the repair of acute defects in animal models; however, the ability of EPCs to induce the repair of chronic nonhealing defects, such as those often encountered clinically, has not been investigated. Therefore, the purpose of this study was to investigate the ability of EPCs delivered in delayed fashion to induce the repair of nonhealing defects in a clinically relevant model. In order to simulate delayed treatment, 5 mm segmental defects in Fischer 344 …

Diagnostic Validity Of Patient-Reported History For Shoulder Pathology, Le Somerville, K Willits, Am Johnson, R Litchfield

Bone and Joint Institute

Objective The purpose of this article is to determine whether patient-reported history items are predictive of shoulder pathology and have the potential for use in triaging patients with shoulder pathology to orthopaedic outpatient clinics. Setting It is set at two tertiary orthopaedic clinics. Patients All new patients reporting pain and/or disability of the shoulder joint were prospectively recruited. A total of 193 patients were enrolled, 15 of whom withdrew, leaving 178 patients composing the study sample. Design Patients completed a questionnaire on the history of their pathology, then the surgeon took a thorough history indicating the most likely diagnosis. The …

Hippocampal Neurogenesis And Volume In Migrating And Wintering Semipalmated Sandpipers (Calidris Pusilla)., Nara Gyzely De Morais Magalhães, Cristovam Guerreiro Diniz, Daniel Guerreiro Diniz, Ediely Pereira Henrique, Patrick Douglas Corrêa Pereira, Isis Ananda Matos Moraes, Mauro André Damasceno De Melo, David Francis Sherry, Cristovam Wanderley Picanço Diniz

Brain and Mind Institute Researchers' Publications

Long distance migratory birds find their way by sensing and integrating information from a large number of cues in their environment. These cues are essential to navigate over thousands of kilometers and reach the same breeding, stopover, and wintering sites every year. The semipalmated sandpiper (Calidris pusilla) is a long-distance migrant that breeds in the arctic tundra of Canada and Alaska and winters on the northeast coast of South America. Its fall migration includes a 5,300-kilometer nonstop flight over the Atlantic Ocean. The avian hippocampus has been proposed to play a central role in the integration of multisensory spatial information …

Are There Place Cells In The Avian Hippocampus?, David F Sherry, Stephanie L Grella, Mélanie F Guigueno, David J White, Diano F Marrone

Brain and Mind Institute Researchers' Publications

Birds possess a hippocampus that serves many of the same spatial and mnemonic functions as the mammalian hippocampus but achieves these outcomes with a dramatically different neuroanatomical organization. The properties of spatially responsive neurons in birds and mammals are also different. Much of the contemporary interest in the role of the mammalian hippocampus in spatial representation dates to the discovery of place cells in the rat hippocampus. Since that time, cells that respond to head direction and cells that encode a grid-like representation of space have been described in the rat brain. Research with homing pigeons has discovered hippocampal cells, …

Hippocampal Astrocytes In Migrating And Wintering Semipalmated Sandpiper, Dario Carvalho-Paulo, Nara G De Morais Magalhães, Diego De Almeida Miranda, Daniel G Diniz, Ediely P Henrique, Isis A M Moraes, Patrick D C Pereira, Mauro A D De Melo, Camila M De Lima, Marcus A De Oliveira, Cristovam Guerreiro-Diniz, David F Sherry, Cristovam W P Diniz

Brain and Mind Institute Researchers' Publications

Seasonal migratory birds return to the same breeding and wintering grounds year after year, and migratory long-distance shorebirds are good examples of this. These tasks require learning and long-term spatial memory abilities that are integrated into a navigational system for repeatedly locating breeding, wintering, and stopover sites. Previous investigations focused on the neurobiological basis of hippocampal plasticity and numerical estimates of hippocampal neurogenesis in birds but only a few studies investigated potential contributions of glial cells to hippocampal-dependent tasks related to migration. Here we hypothesized that the astrocytes of migrating and wintering birds may exhibit significant morphological and numerical differences …

Of Bayes And Bullets: An Embodied, Situated, Targeting-Based Account Of Predictive Processing, M.L. Anderson

Brain and Mind Institute Researchers' Publications

No abstract provided.

Neurometabolic Abnormalities In Schizophrenia And Depression Observed With Magnetic Resonance Spectroscopy At 7 T, Reggie Taylor, Elizabeth A Osuch, Betsy Schaefer, Nagalingam Rajakumar, Richard W J Neufeld, Jean Theberge, Peter C Williamson

Department of Medicine Publications

BACKGROUND: Examining neurometabolic abnormalities in critical brain areas in schizophrenia and major depressive disorder (MDD) may help guide future pharmacological interventions including glutamate-modulating treatments.

AIMS: To measure metabolite concentrations within the anterior cingulate cortex (ACC) and thalamus of people with schizophrenia and people with MDD.

METHODS: Spectra were acquired from 16 volunteers with schizophrenia, 17 with MDD and 18 healthy controls using magnetic resonance spectroscopy on a 7 Tesla scanner.

RESULTS: In the thalamus, there were lower glycine concentrations in the schizophrenia group relative to control (P=0.017) and MDD groups (P=0.012), and higher glutamine concentrations relative to healthy controls (P=0.009). …

Desynchronization Of Autonomic Response And Central Autonomic Network Connectivity In Posttraumatic Stress Disorder, Janine Thome, Maria Densmore, Paul A Frewen, Margaret C Mckinnon, Jean Théberge, Andrew A Nicholson, Julian Koenig, Julian F Thayer, Ruth A Lanius

Department of Medicine Publications

OBJECTIVES: Although dysfunctional emotion regulatory capacities are increasingly recognized as contributing to posttraumatic stress disorder (PTSD), little work has sought to identify biological markers of this vulnerability. Heart rate variability (HRV) is a promising biomarker that, together with neuroimaging, may assist in gaining a deeper understanding of emotion dysregulation in PTSD. The objective of the present study was, therefore, to characterize autonomic response patterns, and their related neuronal patterns in individuals with PTSD at rest.

METHODS: PTSD patients (N = 57) and healthy controls (N = 41) underwent resting-state fMRI. Connectivity patterns of key regions within the central autonomic network …

Discrete Event Simulation Model For Planning Level 2 “Step-Down” Bed Needs Using Nems, Felipe F. Rodrigues, Gregory S. Zaric, David Stanford

Business Publications

In highly congested hospitals it may be common for patients to overstay at Intensive Care Units (ICU) due to blockages and imbalances in capacity. This is inadequate clinically, as patients occupy a service they no longer need; operationally, as it disrupts flow from upstream units; and financially as ICU beds are more expensive than ward beds. Step-down beds, also known as Level 2 beds, have become an increasingly popular and less expensive alternative to ICU beds to deal with this issue. We developed a discrete event simulation model that estimates Level 2 bed needs for a large university hospital. The …

Chironian 2017, New York Medical College

The Chironian

No abstract provided.

High Prevalence Of Non-Communicable Diseases And Associated Risk Factors Amongst Adults Living With Hiv In Cambodia, Pheak Chhoun, Sovannary Tuot, Anthony D. Harries, Nang Thu Thu Kyaw, Khuondyla Pal, Carinne M. Brody, Siyan Yi

BACKGROUND:

With rapid expansion of antiretroviral therapy for HIV, there are rising life expectancies among people living with HIV. As a result, co-morbidity from non-communicable diseases in those living and aging with HIV is increasingly being reported. Published data on this issue have been limited in Cambodia. The aim of this study was to determine the prevalence of diabetes mellitus, hypertension and hypercholesterolemia and associated risk factors in adults living with HIV in Cambodia.

METHODS:

This cross-sectional study was conducted in five provinces of Cambodia from May-June 2015. Information was obtained on socio-demographic and clinical characteristics through face-to-face interviews using …

How Harm Reduction Programs Work In The Context Of Village And Commune Safety Policy: Lessons Learned From A National Non-Governmental Organization In Cambodia, Sovannary Tuot, Sopheab Heng, Chhorvann Chhea, Eunice Salonga, Siyan Yi

This paper aims to examine the challenges and implications of the Village and Commune Safety Policy (VCSP) on harm-reduction programs and describe lessons learned from a harm-reduction program within the context of the VCSP in Cambodia. Data were collected from a monitoring and evaluation database and reports of a drop-in center that provides a wide range of harm-reduction services. In addition, qualitative data were collected through key informant interviews and focus group discussions with 38 participants including people who use drugs (PWUD) and people who inject drugs (PWID). Desk reviews and consultative meetings with key stakeholders were also conducted. In …

A Quality Improvement Project: Adopting The Standards Of Best Practice In Simulation: Debriefing With Pearls, Rebecca Lea Hooper Keesee

Doctor of Nursing Practice Projects

Background

There is evidence the best practices of simulation, specifically, the use of debriefing, will assist the new graduate nurse’s transition into the profession by increasing their clinical judgment. This quality improvement (QI) project explored the pedagogy of High Fidelity Simulation and Debriefing as a solution for the lag in New Graduate Nurse (NGN) practice readiness. The specific aims of this project were: 1) to teach the NGN residency educators how to implement Standard: Debriefing of the International Nursing Association for Clinical Simulation and Learning (INACSL) Standards of Best Practices: Simulation^SM by focusing on the role of the debriefer; …

Factors Affecting Student Success In Oregon Associate Degree Nursing Programs, Tracy Fawns

Doctor of Nursing Practice Projects

Background: Multiple factors contribute to student retention and attrition rates in undergraduate nursing programs. Attrition rates are rising, which affects society as the population is aging and there is a need for more nurses. Identifying attrition risk as a method to increase student success is imperative in order to produce more nurses. The purpose of this project was to analyze and evaluate predictive factors and academic issues that affect student success at Oregon Consortium of Nursing Education (OCNE) schools in order decrease attrition rates in the science courses and increase associate degree of nursing (ADN) program completion.

Methods: This records-based …

January 2017, New England Osteopathic Heritage Center

New England Osteopathic Heritage Center Newsletter

New England Osteopathic Heritage Center's annual newsletter for January 2017

Quantifying Variation In Gait Features From Wearable Inertial Sensors Using Mixed Effects Models, Kellen Garrison Cresswell, Yongyun Shin, Shanshan Chen

Biostatistics Publications

The emerging technology of wearable inertial sensors has shown its advantages in collecting continuous longitudinal gait data outside laboratories. This freedom also presents challenges in collecting high-fidelity gait data. In the free-living environment, without constant supervision from researchers, sensor-based gait features are susceptible to variation from confounding factors such as gait speed and mounting uncertainty, which are challenging to control or estimate. This paper is one of the first attempts in the field to tackle such challenges using statistical modeling. By accepting the uncertainties and variation associated with wearable sensor-based gait data, we shift our efforts from detecting and correcting …

Comorbidity, Pain, Utilization, And Psychosocial Outcomes In Older Versus Younger Sickle Cell Adults: The Pisces Project, Donna K. Mcclish, Wally R. Smith, James L. Levenson, Imoigele P. Aisiku, John D. Roberts, Susan D. Roseff, Viktor E. Bovbjerg

Biostatistics Publications

Background. Patients with SCD now usually live well into adulthood. Whereas transitions into adulthood are now often studied, little is published about aging beyond the transition period. We therefore studied age-associated SCD differences in utilization, pain, and psychosocial variables. Methods. Subjects were 232 adults in the Pain in Sickle Cell Epidemiology Study (PiSCES). Data included demographics, comorbidity, and psychosocial measures. SCD-related pain and health care utilization were recorded in diaries. We compared 3 age groups: 16–25 (transition), 26–36 (younger adults), and 37–64 (older adults) years. Results. Compared to the 2 adult groups, the transition group reported fewer …

Tobacco Use And Health Insurance Literacy Among Vulnerable Populations: Implications For Health Reform, Robert T. Braun, Yaniv Hanoch, Andrew J. Barnes

Health Policy Publications

Background: Under the Affordable Care Act (ACA), millions of Americans have been enrolling in the health insurance marketplaces. Nearly 20% of them are tobacco users. As part of the ACA, tobacco users may face up to 50% higher premiums that are not eligible for tax credits. Tobacco users, along with the uninsured and racial/ethnic minorities targeted by ACA coverage expansions, are among those most likely to suffer from low health literacy – a key ingredient in the ability to understand, compare, choose, and use coverage, referred to as health insurance literacy. Whether tobacco users choose enough coverage in the marketplaces …

Educating Mothers Of Obese Hispanic Preschoolers To Create Lifelong Healthy Habits, Lynette Marshall

Doctor of Nursing Practice Projects

Problem and Background: Childhood obesity has doubled in children and quadrupled in adolescents in the past 3 decades, increasing from 5% to 17% in one generation. The highest rates of childhood obesity are among Mexican Americans. Obesity can increase health morbidities, and as obese children continue to grow, these health concerns progress to adulthood. In spite of enhanced education and communication between mothers of obese children and their primary care providers, minimal improvement has taken place in terms of outcomes and lifestyle changes.

Methods: Fourteen obese Hispanic 2- to 5-year-olds and their mothers participated in the study. The children’s BMIs …

Cognitive Performance And Mood Changes In The Post-Thyroidectomy Patient Treated With T4 Versus T4+T3, Lorena Likaj

2017 Program & Posters

This study investigated changes in cognition and mood in the post-thyroidectomy patient. Specifically, this study investigates changes in cognition and mood, when the patient has been returned to normal, laboratory serum thyroid-stimulating hormone (TSH) reference levels, following conventional thyroid hormone replacement therapies with levothyroxine (T4) alone. Findings reveal a distinct, small, and clinically significant subgroup of post-thyroidectomy patients (10–15%) who continue to experience impaired cognition and mood, even when routinely measured serum TSH levels have been returned to normal levels. Findings are discussed within a conceptual matrix emphasizing the differential role of deiodinase enzymes required for conversion of T4 to …

Crafting A System Of Profound Knowledge Management In Long Term Care, Charlotte Johnston

2017 Program & Posters

Healthcare industries face regulatory and funding challenges to improve quality and close knowing-to doing gaps in healthcare. The study presents a substantive conceptual theory for crafting knowledge management (KM) in long-term-care (LTC); and extends Deming’s theory of profound knowledge from an organizational to the individual level of action and decision making.

Qualitative Research And Vicarious Trauma: The Use Of Reflexivity, Dawn Higgins

2017 Program & Posters

Qualitative researchers studying traumatic events may experience vicarious trauma. The research practice of reflexivity addresses biases of the researcher, however, there is no explicit practice to address symptoms of vicarious trauma. In this introspective study, the researcher uses a reflexive worksheet to explore vicarious trauma in her study on 9/ll.

The Relationship Between Pre-Licensure Employment And Student Nurse Self-Efficacy, Khristina Lee Grimm

2017 Program & Posters

Lack of self-efficacy in nursing practice contributes to high levels of stress as new nurses enter the workforce, which causes turnover during their first year of practice. Little is known about how the type and amount of pre-licensure employment affects the selfefficacy in nursing practice of the student nurse.

Labeling Still Matters: The United Nations Development Programme And The Bied Growth Path Model, Kenneth T. Davis

2017 Program & Posters

The Purpose of this study is to review the United Nations Development Programme’s Human Development Index (HDI) labels with the Behavioral International Economic Development Growth Path Model labels to get a better understanding of this new dynamic model and its layered approach. The 2012 HDI labels and previous trends were used along with the CIA World Factbook 2002 and 2012. This study promotes classification labels based on labor force occupation by sector, specifically agrarian, industry, and services behavior.

Sleep Among Young Adults Living In Rural Poverty, Susan Barber Skinner

2017 Program & Posters

Sleep problems are implicated in individual health and public safety issues. This phenomenological study used semi-structured interviews (n = 12) of young adults living in rural poverty. Thematic analysis was used to identify themes including a struggle to balance sleep with preferred activities and a belief that the body controls sleep behavior.

Insurance Status Versus Hospitalized Patient Outcomes With Pulmonary Hypertension: National Hospital Discharge Survey, 2000-2010, Srikanta Banerjee

2017 Program & Posters

Pulmonary Hypertension is a common complication of heart failure or obstructive pulmonary disease. The National Hospital Discharge Survey, the largest national inpatient-based survey, was used for complex samples logistic regression modeling. Findings from this study demonstrated that insurance status had a statistically significant association with hospital related mortality rates.