Medicine and Health Sciences Commons^™

Role Transitioning For Athletes Coping With Injury And Occupational Loss, Steven L. Huft, Izaak P. Schafer

Occupational Therapy Capstones

Purpose: The purpose of this scholarly project was to develop an occupational therapy based intervention program for persons who are experiencing changes in their role as athletes. These transitions may include return to sport following an injury, unanticipated retirement from sport, or anticipated retirement from sport.

Methods: A thorough literature search and review was conducted using the following research databases: CINAHL, Google Scholar, PubMed, and PsycINFO. Evidence from the occupational therapy, physical therapy, athletic training and psychology professions was reviewed regarding the prevalence of injury in varying sports contexts, athletes’ ability to transition during role changes or interruption, injury rehabilitation, …

Students' Experience Of Learning To Use Occupation As Intervention On Fieldwork In Medical Settings, Kelli Atkinson, Nicole Knutson

Occupational Therapy Capstones

There are few studies that focus on students’ experiences of fieldwork; specifically, investigating how students learn to use occupation. In addition, there is limited research regarding the students’ learning to use occupation-based interventions in medical settings. The purpose of this independent study was to explore students’ experience of learning to use occupation as intervention on fieldwork in medical settings and specific strategies used by students and fieldwork educators for learning to use occupation as intervention. A phenomenological, qualitative research design was used with this study. Participants were recruited through the use of the University of North Dakota occupational therapy department …

Illness Management And Recovery: The Role Of Occupational Therapy, Crystal Brecht, Jenna Mcgregor

Occupational Therapy Capstones

Purpose: The Illness Management and Recovery (IMR) model is a collaborative program that focuses on living with a chronic mental illness by educating the client on management techniques that will facilitate goal setting toward recovery (Mueser et al., 2006).The purpose of this scholarly project was to review the occupational therapy (OT) literature and determine the role of OT in IMR programs.

Method: A comprehensive review was conducted on occupational therapy interventions appropriate for inclusion in the IMR modules. Sources utilized for the review included: United States and international OT journals, OT textbooks, and other publications authored by OTs from the …

The Use Of Occupation-Based Interventions In Long-Term Care: A Qualitative Study, Amy Jo. Jensen, Mallory Carlson

Occupational Therapy Capstones

Purpose: To explore occupational therapists' use of occupation- based interventions in long-term care facilities.

Methodology: A literature review was completed on the use and effect occupation-based intervention has within a long-term care practice setting. Based upon the findings of this literature review, a qualitative research study was conducted using a grounded theory approach adopted from Strauss and Corbin (1998). Six occupational therapists working in long-term care facilities in Minnesota were recruited through purposive sampling using convenience and snowballing techniques. Each participant was interviewed once using a semi-structured interview. Data from the interviews was then coded and grouped into categories. Themes …

Caring For Individuals With Fibrodysplasia Ossificans Progressiva (Fop): A Treatment Manual For Occupational Therapists, Amanda Rositas, Kathryn Zavoral

Occupational Therapy Capstones

Fibrodysplasia Ossificans Progressiva is a rare and disabling genetic disorder that results in ossification of the soft tissues (Kaplan, Xu, et al., 2008; Kocyigit, Hizil, Hemis, Sabah, & Memis, 2001). There is a lack of research and literature on therapeutic intervention for those with a diagnosis of FOP. However, occupational therapists (OTs) can help those with FOP increase their quality of life through enhancement of activities of daily living (Kaplan, Le Merrer, et al., 2008). Overall, this product will serve as a guide for occupational therapists working with individuals diagnosed with FOP. The benefits of this product will be determined …

Embracing Life With Als: The Role Of Occupational Therapy From Diagnosis To End Of Life Care, Chelsey Edwards, Amy Ferguson

Occupational Therapy Capstones

Purpose: The purpose of this scholarly project was to develop a comprehensive document that describes the role of the occupational therapist in working with clients and families affected by Amyotrophic Lateral Sclerosis CALS) from diagnosis to end-of-life care.

Method: A literature review was conducted using the AJOT, PubMed, CINAHL, and OT SEARCH databases. Information was gathered regarding current literature of ALS, the disease process, occupational therapy's role in ALS treatment, caregiver's role in end-of-life care, assistive technology, palliative care options, and additional support strategies. Additional ALS material was gathered from the ALS Association's informational manuals.

Results: Designed from the perspective …

Low Back Pain With Psoas Tightness, Trevor Northagen

Physical Therapy Scholarly Projects

Background and Purpose

Low back pain is a prevalent healthcare issue which has a number of causes. There are many types of treatment with varying levels of success. The psoas is a back muscle which may undergo changes in a patient with back pain. Treatment may have to be modified if changes are seen in the psoas.

Case Description

A 66 year-old woman reported low back and right hip pain, as well as right-sided abdominal pain around a surgical incision. The physical therapy examination revealed adhered scar tissue around the incision, psoas muscle tightness, as well as low back and …

Influence Of Foot Position On Lower Extremity Muscle Activation, Casey Darling

Physical Therapy Scholarly Projects

The anterior cruciate ligament (ACL) in the knee is often sprained or torn in injuries resulting from jumping, cutting, or hyperextension of the knee. When the knee is put under a valgus, varus, or rotatory stress it can put strain on the ACL. Lower extremity motor control can help control the amount of varus and valgus stress on the knee. Lower extremity muscle control is involved with preventing this stress and resulting injuries. This study was performed to determine whether the position of the foot (neutral, supination, and pronation) has an effect on lower extremity muscle activity during single-leg squats. …

Fiber Type And Cross-Sectional Area Characteristics In Hindlimb Muscles Of The Long-Lived Ames Dwarf Mouse, David Farder

Physical Therapy Scholarly Projects

Background: Aging is associated with sarcopenia and a change of composition in muscle fibers. Ames dwarf mice have been found to have a decreased susceptibility to the deleterious effects of the aging process, when compared to a normal mouse counterpart. This study looks at the muscle composition of the Ames dwarf mouse compared to the normal mouse by analyzing two muscles, extensor digitorum longus (EDL) and soleus (Sol).

Methods: Researchers harvested hind limb muscles from Ames dwarf mice and normal mice. The fours muscles were EDL, Sol, Gastrocnemius/Plantaris, and tibialis anterior (TA). EDL and Sol were sliced and stained with …

Influence Of Foot Position On Lower Extremity Muscle Activity, Hayley J. Letvin

Physical Therapy Scholarly Projects

Being that the anterior cruciate ligament (ACL) is the most commonly torn ligament, much research has been performed regarding this matter. Females have been found to be more likely to tear their ACL. This may be due to strength, structural (anatomical), hormonal, and neuromuscular differences compared to men. Several studies have also been conducted to help improve preventative measures with using strengthening and neuromuscular training programs. Many speculations have been made about the precipitating factors of an ACL injury. The general consensus in regard to foot placement is that the foot is usually placed in pronation during an ACL tear. …

Use Of Robotics In Spinal Cord Injury: A Case Report., Lori Siedziewski, Roseann C. Schaaf, Julie Mount

Department of Occupational Therapy Faculty Papers

OBJECTIVE: We examined the use of robotics to treat upper-extremity (UE) dysfunction in tetraplegic patients with spinal cord injury (SCI).

METHOD: a 51-yr-old man with incomplete SCI participated in an occupational therapy program that combined traditional occupational therapy with Reo Go®, a comprehensive therapy platform that includes a robotic guide featuring a telescopic arm to enable high repetitions of functionally relevant UE exercises.

RESULTS: The participant demonstrated measurable improvements in active range of motion, muscle strength as measured through manual muscle testing, perceived right UE function, and self-care performance as measured by the FIM™.

CONCLUSION: The findings from this case …

Natural Antiparasitic Coumarins: An In Silico Study, William R. Erwin

Summer Community of Scholars Posters (RCEU and HCR Combined Programs)

No abstract provided.

Common Features At The Start Of The Neurodegeneration Cascade, Rubén Hervás, Javier Oroz, Albert Galera-Prat, Oscar Goñi, Alejandro Valbuena, Andrés M. Vera, Àngel Gómez-Sicilia, Fernando Losada-Urzáiz, Vladimir N. Uversky, Margarita Menéndez, Douglas V. Laurents, Marta Bruix, Mariano Carrión-Vázquez

Molecular Medicine Faculty Publications

Amyloidogenic neurodegenerative diseases are incurable conditions with high social impact that are typically caused by specific, largely disordered proteins. However, the underlying molecular mechanism remains elusive to established techniques. A favored hypothesis postulates that a critical conformational change in the monomer (an ideal therapeutic target) in these “neurotoxic proteins” triggers the pathogenic cascade. We use force spectroscopy and a novel methodology for unequivocal single-molecule identification to demonstrate a rich conformational polymorphism in the monomer of four representative neurotoxic proteins. This polymorphism strongly correlates with amyloidogenesis and neurotoxicity: it is absent in a fibrillization-incompetent mutant, favored by familial-disease mutations and diminished …

Morfpred, A Computational Tool For Sequence-Based Prediction And Characterization Of Short Disorder-To-Order Transitioning Binding Regions In Proteins, Fatemeh Miri Disfani, Wei-Lun Hsu, Marcin J. Mizianty, Christopher J. Oldfield, Bin Xue, A. Keith Dunker, Vladimir N. Uversky, Lukasz Kurgan

Molecular Medicine Faculty Publications

Motivation: Molecular recognition features (MoRFs) are short binding regions located within longer intrinsically disordered regions that bind to protein partners via disorder-to-order transitions. MoRFs are implicated in important processes including signaling and regulation. However, only a limited number of experimentally validated MoRFs is known, which motivates development of computational methods that predict MoRFs from protein chains.

Results: We introduce a new MoRF predictor, MoRFpred, which identifies all MoRF types (α, β, coil and complex). We develop a comprehensive dataset of annotated MoRFs to build and empirically compare our method. MoRFpred utilizes a novel design in which annotations generated by sequence …

Understanding Viral Transmission Behavior Via Protein Intrinsic Disorder Prediction: Coronaviruses, Gerard Kian-Meng Goh, A. Keith Dunker, Vladimir N. Uversky

Molecular Medicine Faculty Publications

Besides being a common threat to farm animals and poultry, coronavirus (CoV) was responsible for the human severe acute respiratory syndrome (SARS) epidemic in 2002–4. However, many aspects of CoV behavior, including modes of its transmission, are yet to be fully understood. We show that the amount and the peculiarities of distribution of the protein intrinsic disorder in the viral shell can be used for the efficient analysis of the behavior and transmission modes of CoV. The proposed model allows categorization of the various CoVs by the peculiarities of disorder distribution in their membrane (M) and nucleocapsid (N). This categorization …

Professional Product Review Vol. 7 No. 1, American Dental Association, Council On Scientific Affairs

Professional Product Review

A user-friendly newsletter from the ADA Council on Scientific Affairs offering scientifically sound, unbiased, and clinically relevant information to member dentists about professional dental products tested by the ADA. This collection is historical and may not reflect current standards. For up-to-date information contact the ADA.

Professional Product Review Vol. 7 No. 2, American Dental Association, Council On Scientific Affairs

Professional Product Review

A user-friendly newsletter from the ADA Council on Scientific Affairs offering scientifically sound, unbiased, and clinically relevant information to member dentists about professional dental products tested by the ADA. This collection is historical and may not reflect current standards. For up-to-date information contact the ADA.

Professional Product Review Vol. 7 No. 3, American Dental Association, Council On Scientific Affairs

Professional Product Review

A user-friendly newsletter from the ADA Council on Scientific Affairs offering scientifically sound, unbiased, and clinically relevant information to member dentists about professional dental products tested by the ADA. This collection is historical and may not reflect current standards. For up-to-date information contact the ADA.

Purification Of Alpha-Glucosidase Inhibitors From Grape Extract, Gayle M. Shipp

Wayne State University Theses

ABSTRACT

PURIFICATION OF ALPHA-GLUCOSIDASE INHIBITORS FROM GRAPE EXTRACT

by

GAYLE SHIPP

August 2012

Advisor: Dr. Kevin Zhou

Major: Nutrition and Food Science

Degree: Master of Science

Diabetes and its complications are steadily growing and remain major causes of morbidity and mortality in the U.S. Intestinal á-glucosidases play a crucial role in controlling postprandial blood glucose. For this reason, one attractive prevention and/or treatment strategy for type-2 diabetes is the inhibition of á-glucosidase. The effectiveness of á-glucosidase inhibitors (AGI's) for diabetes treatment is well documented in numerous animal and human clinical studies. Grape pomace extract (GPE) has recently found in our …

Modulation Of Anti-Tumor Immune Response By Tgf-Β-Inducible Early Gene 1 (Tieg1), Andi Cani

Wayne State University Theses

Cancer immunotherapy has had limited clinical efficacy partly because regulatory T cells (Treg) suppress the immune response to tumor-associated antigens. Inducible regulatory T cells (iTreg), which are converted from naïve CD4 T cells by TGF-β, an abundant cytokine in the tumor microenvironment, may contribute to this immune suppression. Induction of Foxp3 by TGF-β is mediated by the transcription factor TIEG1 and abrogation of this protein prevents Foxp3 expression. We are testing the hypothesis that blockade of TIEG1 to prevent iTreg conversion will enhance immune response in DNA vaccination to the tumor associated antigen Her-2. Wild type and TIEG1 knockout mice …

Ubiquitous Learning Laboratory For Pediatric Nursing: A Cultural Algorithm Approach, David Lee Colon

Wayne State University Theses

ABSTRACT

UBIQUITOUS LEARNING LABORATORY FOR PEDIATRIC NURSING: A CULTURAL ALGORITHM APPROACH

by

DAVID L. COLON

December 2012

Advisor: Dr. Robert G. Reynolds

Major: Computer Science

Degree: Master of Science

Quality Medical Care is at the focus of all health care service providers. Each facility maintains a standard level of care that promises not only a precise diagnosis, but also the correct course of treatment. In part, this is due to the educational training and professional experience of Nurses. For high-risk patients such as children, the level of expertise of a Pediatric Nurse is even more critical in order to guarantee …

Itch Occurring With Chronic Wounds, Julia Claire Paul

Wayne State University Dissertations

Abstract

Ada News Convention Daily - 2012 Day 1, American Dental Association, Publishing Division

ADA News

The ADA News Daily (also called the ADA News Convention Daily) is a special edition of the ADA News published each day during American Dental Association Annual Sessions.

Ada News Convention Daily - 2012 Day 4, American Dental Association, Publishing Division

ADA News

The ADA News Daily (also called the ADA News Convention Daily) is a special edition of the ADA News published each day during American Dental Association Annual Sessions.

Clinical Skills Assessment Of Procedural And Advanced Communication Skills: Performance Expectations Of Residency Program Directors., E. E. Langenau, X. Zhang, W. L. Roberts, A. F. Dechamplain, J. R. Boulet

PCOM Scholarly Works

High stakes medical licensing programs are planning to augment and adapt current examinations to be relevant for a two-decision point model for licensure: entry into supervised practice and entry into unsupervised practice. Therefore, identifying which skills should be assessed at each decision point is critical for informing examination development, and gathering input from residency program directors is important. Using data from previously developed surveys and expert panels, a web-delivered survey was distributed to 3,443 residency program directors. For each of the 28 procedural and 18 advanced communication skills, program directors were asked which clinical skills should be assessed, by whom, …

"First Impression": Creating An Intake Procedure That Is Welcoming To Clients And Useful To Clinicians, Brandi Embacher

All Graduate Theses, Dissertations, and Other Capstone Projects

Have you ever contacted an agency and felt doubtful about their ability to help you due to the phone interaction or written correspondence you received? The significance of this Capstone project is to create an intake procedure that will leave a positive first impression for individuals seeking services with Mankato Marriage and Family Therapy Center (MMFTC).

Study Guide For United In Anger: A History Of Act Up, Matt Brim

Open Educational Resources

The United in Anger Study Guide facilitates classroom and activist engagement with Jim Hubbard’s 2012 documentary, United in Anger: A History of ACT UP. The Study Guide contains discussion sections, projects and exercises, and resources for further research about the activism of the New York chapter of ACT UP (AIDS Coalition to Unleash Power). The Study Guide is a free, interactive, multimedia resource for understanding the legacy of ACT UP, the film’s role in preserving that legacy, and its meaning for viewers' lives.

Theorizing Mental Health Courts, E. Lea Johnston

UF Law Faculty Publications

To date, no scholarly article has analyzed the theoretical basis of mental health courts, which currently exist in forty-three states. This Article examines the two utilitarian justifications proposed by mental health court advocates—therapeutic jurisprudence and therapeutic rehabilitation—and finds both insufficient. Therapeutic jurisprudence is inadequate to justify mental health courts because of its inability, by definition, to resolve significant normative conflict. In essence, mental health courts express values fundamentally at odds with those underlying the traditional criminal justice system. Furthermore, the sufficiency of rehabilitation, as this concept appears to be defined by mental health court advocates, depends on the validity of …

Effects Of Apoptotic Cell Accumulation Caused By Mer Deficiency On Germinal Center B Cells And Helper T Cells, Tahsin N. Khan, Eric B. Wong, Ziaur S.M. Rahman

Department of Microbiology and Immunology Faculty Papers

Mer (MerTK), a member of the Tyro-3/Axl/Mer subfamily receptor tyrosine kinases, expression on phagocytes facilitates their clearance of apoptotic cells (ACs). Mer expression in germinal centers (GCs) occurs predominantly on tingible body macrophages. B and T cells do not express Mer. Mer deficiency (Mer-/-) results in the accumulation of ACs in GCs and augmented antibody-forming cell (AFC), GC and IgG2 Ab responses against T-dependent (TD) Ag. Here, we show that AC accumulation in GCs and elevated AFC, GC and IgG2 Ab responses in Mer-/- mice lasted for at least 80 days after immunization with NP-OVA. Enhanced responses and AC accumulation …

A Novel Function For Snap29 (Synaptosomal-Associated Protein Of 29 Kda) In Mast Cell Phagocytosis., Jordan Wesolowski, Vernon Caldwell, Fabienne Paumet

Department of Microbiology and Immunology Faculty Papers

Mast cells play a critical role in the innate immune response to bacterial infection. They internalize and kill a variety of bacteria and process antigen for presentation to T cells via MHC molecules. Although mast cell phagocytosis appears to play a significant role during bacterial infection, little is known about the proteins involved in its regulation. In this study, we demonstrate that the SNARE protein SNAP29 is involved in mast cell phagocytosis. SNAP29 is localized in the endocytic pathway and is transiently recruited to Escherichia coli (E. coli)-containing phagosomes. Interestingly, overexpression of SNAP29 significantly increases the internalization and killing of …