Medicine and Health Sciences Commons^™

Current Exercise Behaviors Of Breast Cancer Patients Diagnosed With Chemotherapy-Induced Peripheral Neuropathy, Karen Y. Wonders, Daniel G. Drury

Health Sciences Faculty Publications

Introduction: Chemotherapy-induced peripheral neuropathy (CIPN) is a common, dose-limiting effect of cancer therapy. The neuropathic pain associated with CIPN often has negative implications on an individual’s quality of life (QOL) and has long been recognized as one of the more difficult types of pain to treat. Treatment of neuropathic pain due to CIPN often requires a multidisciplinary approach, with much attention focused on the use of pharmacological therapies. However, in most instances, these agents have been shown to have additional negative side effects for cancer patients. Thus, other interventions that address the symptoms of CIPN should be considered. One such …

A Case Report: Familial Glucocorticoid Deficiency Associated With Familial Focal Segmental Glomerulosclerosis, Nanik Ram, Ali Asghar, Najmul Islam

Section of Diabetes, Endocrinology and Metabolism

Background: Familial glucocorticoid deficiency (FGD) is a rare autosomal recessive disorder characterized by isolated glucocorticoid deficiency in the presence of normal plasma renin and aldosterone level. Focal segmental glomerulosclerosis (FSGS) is a form of glomerular disease associated with proteinuria and nephritic syndrome. This is the first case of familial glucocorticoid deficiency associated with familial focal segmental glomerulosclerosis.

Case Presentation: An eight month old boy presented with increased genital pigmentation. Initial investigation revealed that he was glucocorticoid deficient and was started on hydrocortisone and fludrocortisone with a diagnosis of primary adrenal insufficiency. Later fludrocortisone was withdrawn and he was diagnosed to …

The Neurophysiology Of Adr And Process Design: A New Approach To Conflict Prevention And Resolution?, Jeremy Lack, François Bogacz

Cardozo Journal of Conflict Resolution

Neurobiology seems to be popping up everywhere. It is being taught in leadership conferences, sales and marketing seminars, management meetings, business schools, and increasingly in law schools and bar associations. The cover of the American Bar Association's Summer 2011 Dispute Resolution Magazine was dedicated to the topic of "Neuroscience and Negotiation." In it, Professor Richard Birke observes that "Neuroscience is everywhere." Is it a new fad or a fundamental awakening, providing new insights for the legal profession?

Adolescent Depression Screening Practices Among Texas Pediatric And Family Nurse Practitioners, Carol S. Lieser

Nursing Dissertations - Archive

Depression is a common mental health concern for adolescents that , if not treated, may lead have lifelong consequences. Yet, many in this population are not diagnosed and thus remain untreated. Advanced practice nurse practitioners, in their places of employment, have opportunities to interact with adolescents. They are skilled and trained in health promotion and disease prevention practices. No studies were found that examined screening practices for adolescent depression of nurse practitioners, factors affecting their screening practices, and their management of adolescents whom they determine are depressed. The purpose of this study was 1) to describe the background factors of …

A Qualitative Study Using Traditional Community Assemblies To Investigate Community Perspectives On Informed Consent And Research Participation In Western Kenya, Rachel Vreeman, Eunice Kamaara, Allan Kamanda, David Ayuku, Winstone Nyandiko, Lukoye Atwoli, Samuel Ayaya, Peter Gisore, Michael Scanlon, Paula Braitstein

Paediatrics and Child Health, East Africa

Background: International collaborators face challenges in the design and implementation of ethical biomedical research. Evaluating community understanding of research and processes like informed consent may enable researchers to better protect research participants in a particular setting; however, there exist few studies examining community perspectives in health research, particularly in resource-limited settings, or strategies for engaging the community in research processes. Our goal was to inform ethical research practice in a biomedical research setting in western Kenya and similar resource-limited settings.

Methods: We sought to use mabaraza, traditional East African community assemblies, in a qualitative study to understand community perspectives on …

Clinical Decisions, Margaret Fish

VA Engage Journal

From the very beginning of my experience in the dental hygiene program, patient care has been the central focus. Not just in administrating dental hygiene services, but in their safety. Every patient presenting to the clinic for treatment has their blood pressure measured. I would like to compare two very similar incidents with two different responses by the clinic staff I have experienced while on external rotation.

A Quantitative Examination Of Extreme Facial Pain Expression In Neonates: The Primal Face Of Pain Across Time, Martin Schiavenato, Carl L. Von Baeyer

Nursing Faculty Scholarship

Many pain assessment tools for preschool and school-aged children are based on facial expressions of pain. Despite broad use, their metrics are not rooted in the anatomic display of the facial pain expression. We aim to describe quantitatively the patterns of initiation and maintenance of the infant pain expression across an expressive cycle. We evaluated the trajectory of the pain expression of three newborns with the most intense facial display among 63 infants receiving a painful stimulus. A modified “point-pair” system was used to measure movement in key areas across the face by analyzing still pictures from video recording the …

Integrating Sexual Objectification With Object Versus Person Recognition: The Sexualized-Body-Inversion Hypothesis, Philippe Bernard, Sarah J. Gervais, Jill Allen, Sophie Campomizzi, Olivier Klein

Department of Psychology: Faculty Publications

In the study reported here, we tested the novel sexualized-body-inversion hypothesis. Integrating research and theory on objectification and person versus object recognition, we examined whether sexualized women, but not sexualized men, are recognized in the same way as objects are. According to objectification theory (Fredrickson & Roberts, 1997), female bodies are scrutinized and evaluated to a greater degree than male bodies are, which leads to sexual objectification of women. Defined as viewing or treating an individual as a sexualized body, or as sexualized body parts, available for satisfying the needs and desires of other people (Bartky, 1990), sexual objectification has …

Aqueous-Methanolic Extract Of Sweet Flag (Acorus Calamus) Possesses Cardiac Depressant And Endothelial-Derived Hyperpolarizing Factor-Mediated Coronary Vasodilator Effects., Abdul Jabbar Shah, Anwar Gilani

Department of Biological & Biomedical Sciences

This investigation was aimed to probe the pharmacological base of medicinal use of Acorus calamus in ischemic heart diseases. Effect on heart parameters was studied in isolated rabbit heart while coronary vasodilator effect was studied in isolated bovine coronary arterial rings, suspended in tissue baths filled with Krebs solution, maintained at 37degreesC, aerated with carbogen and responses were measured on PowerLab data acquisition system. In Langendorrf's perfused rabbit heart, the crude extract of Acorus calamus (Ac.Cr) at 0.01-10 mg/mL partially suppressed force of ventricular contractions (FVC), heart rate (HR) and coronary flow (CF). The ethylacetate fraction completely suppressed FVC, partially …

Intestinal, Airway, And Cardiovascular Relaxant Activities Of Thymoquinone, Muhammad Nabeel Ghayur, Anwar Hussain Gilani, Luke Jeffrey Janssen

Department of Biological & Biomedical Sciences

Thymoquinone (TQ) is a bioactive component found in many medicinal herbs. In this study, we report the smooth and cardiac muscle relaxant activities of this compound. TQ concentration dependently suppressed spontaneously contracting rabbit jejunum while also relaxed high K+-(80 mM) induced contractions in jejunum and guinea-pig ileum, indicating activity at voltage-operated Ca++ channels (VOCC). Further, TQ displaced Ca++ concentration-response curves, obtained in a Ca++-free environment, to the right, showing blockade of VOCC. Similar activity was observed with verapamil, a standard VOCC blocker. TQ also exhibited nonadrenergic relaxation of agonist-induced contractions in guinea-pig trachea. When tested in fluo-4-loaded mouse lung slices, …

Evaluation Of Gut Modulatory And Bronchodilator Activities Of Amaranthus Spinosus Linn, Mueen Ahmad Chaudhary, Imran Imran, Samra Bashir, Hassan Mehmood, Najeeb-Ur Rehman, Anwarul-Hassan Gilani

Department of Biological & Biomedical Sciences

Background: The aqueous-methanolic extract of Amaranthus spinosus (A. spinosus Linn.,) whole plant, was studied for its laxative, spasmolytic and bronchodilator activities to validate some of its medicinal uses.
Methods: The crude extract of A. spinosus was studied in-vivo for bronchodilator and laxative activities and in-vitro using isolated tissue preparations which were mounted in tissue baths assembly containing physiological salt solutions, maintained at 37°C and aerated with carbogen, to assess the spasmolytic effect and to find out the possible underlying mechanisms.
Results: In the in-vivo experiments in mice, the administration of A. spinosus increased fecal output at doses of 100 …

Nonclinical Development Needs And Regulatory Requirements For Multipurpose Prevention Technologies: A Primer, Joseph W. Romano, Martha Brady, Judy Manning

HIV and AIDS

This summary outlines key development elements that will be necessary for various configurations of multipurpose prevention products for the simultaneous prevention of HIV, sexually transmitted infections, and/or pregnancy.

Assessing And Improving Self-Reporting Of Male Circumcision In Zambia And Swaziland, Paul C. Hewett, Nicole Haberland, Barbara Mensch, Louis Apicella

HIV and AIDS

The Male Circumcision (MC) Partnership was established with the support of the Gates Foundation and PEPFAR to scale up MC services in Zambia, in collaboration with the Zambian government. The MC Partnership is a five-year project led by Population Services International (Society for Family Health, Zambia), in partnership with Jhpiego, Marie Stopes International (MSI), and the Population Council. The ultimate objective of this study is to provide researchers and program managers with evidence-based recommendations for the collection of self-reported data on MC status through an assessment of different methods to describe and explain MC. Specifically, the study assessed tools for …

The Experiences Of Men Engaged In Transactional Sex With Other Men In Urban Nigeria—A Size Estimation And Qualitative Study, Population Council

HIV and AIDS

Reports on a mixed-method research study to estimate the population size and understand the experiences of a sub-group of men who have sex with men presumed to be at particularly high risk of infection with HIV and other sexually transmitted infections: men who engage in transactional sex with other men.

Shaping The Operations Research Agenda For Antiretroviral-Based Prevention Products For Women: Gels And Rings, Martha Brady, C. Elizabeth Mcgrory

HIV and AIDS

This report summarizes discussions from a two-day international experts consultation meeting in 2012 on preparing for the successful introduction of women-centered antiretroviral-based HIV prevention methods. It examines the limits and expectations of operations research in antiretroviral health technologies.

Getting Real With Youth-Friendly Services In Africa: Report Of A Satellite Session At The Xix International Aids Conference, Population Council

HIV and AIDS

Overview of an AIDS 2013 satellite session which aimed to engage young people with and react to the study findings and in the light of the findings, discuss and share their perspectives, experiences and concerns about how responsive existing policies, programs and services are to the HIV prevention and impact mitigation needs of young Africans.

Using Capture-Recapture Methodology For Enumerating Most-At-Risk Populations (Marps), Population Council

HIV and AIDS

Populations at higher risk for HIV infection are often the most difficult to reach and this is particularly true of men who have sex with men (MSM), injecting drug users, and female sex workers in sub-Saharan Africa. These subpopulations are frequently marginalized by society because of the illicit and/or illegal activities they engage in. Estimating the size of hard-to-reach populations is important to effectively plan, implement, monitor, and evaluate HIV and AIDS prevention and care programs. “Capture-recapture” is a method of estimating the prevalence of a trait in a population or more simply it’s a method that provides a good …

An Assessment Of Individual And Institutional Research Utilization By Policy-Makers And Programme Managers At State And National Levels In Nigeria, National Agency For The Control Of Aids

HIV and AIDS

This report undertakes a systematic assessment of the need for evidence by decision-makers working on HIV and AIDS funding and policymaking, and implementing organizations at the national and subnational levels in Nigeria. The assessment identifies barriers and constraints to data use, identifies best practices, and offers recommendations for the design and prioritization of strategic approaches to address barriers and constraints in data use and production. Tools to monitor the adoption of evidence in policy and practice are also offered. The need for evidence-based practice in the national response to HIV and AIDS has been widely acknowledged and incorporated into policy …

An Ethnographic Study Of Injecting Drug Users And Men Who Have Sex With Men In Selected States In Nigeria, Enhancing Nigeria's Hiv/Aids Response (Enr) Programme

HIV and AIDS

An ethnographic pre-assessment study of the behavioral dynamics of men who have sex with men (MSM) and injecting drug users (IDU) was conducted in 2009 as an integral part of the 2010 Integrated Biological and Behavioural Surveillance Survey (IBBSS). The study took place in Northern and Southern Nigeria and provided rich contextual information on the logistic and scientific factors that would aid successful conduct of the IBBSS and secure buy-in for it among study respondents. The study utilized a combination of rapid assessment procedures that were suitable to prevailing time exigencies and could foster preliminary understanding of the local contexts …

Community Perspectives On Research Consent Involving Vulnerable Children In Western Kenya, Rachel Vreeman, Eunice Kamaara, Allan Kamanda, David Ayuku, Winstone Nyandiko, Lukoye Atwoli, Samuel Ayaya, Peter Gisore, Michael Scanlon, Paula Braitstein

Paediatrics and Child Health, East Africa

Involving vulnerable pediatric populations in international research requires culturally appropriate ethical protections. We sought to use mabaraza, traditional East African community assemblies, to understand how a community in western Kenya viewed participation of children in health research and informed consent and assent processes. Results from 108 participants revealed generally positive attitudes towards involving vulnerable children in research, largely because they assumed children would directly benefit. Consent from parents or guardians was understood as necessary for participation while gaining child assent was not. They felt other caregivers,community leaders, and even community assemblies could participate in the consent process. Community members believed …

Cellular Plasticity In White Adipose Tissue: In Vivo Identification Of Bipotent Adipocyte Progenitors In Adult White Adipose Tissue, Yun-Hee Lee

Wayne State University Dissertations

Nutritional and pharmacological stimuli can dramatically alter the cellular composition and phenotype of white adipose tissue (WAT). Nonetheless, the identity of progenitors that contribute to this cellular plasticity in vivo remains poorly understood. Utilizing genetic lineage tracing techniques in combination with in situ imunohistochemical analysis, we demonstrate that brown adipocytes (BA) that are induced by beta3-adrenergic receptor activation (ADRB3) in WAT arise from the proliferation and differentiation of cells that express platelet-derived growth factor receptor alpha (PDGFRA), CD34 and Sca1 (PDGFRA+ cells). PDGFRA+ cells have a unique morphology in which extended processes contact multiple cells in the tissue microenvironment. Surprisingly, …

Perceived And Functional Disability In Adults With Chronic Pain: What Accounts For Discrepancies?, Dana Catharine Nevedal

Wayne State University Dissertations

Disability among patients with chronic pain can be assessed functionally (behaviorally) or subjectively (self-report). However, discrepancies--including low or zero correlations--between these methods are commonly reported. Research suggests that subjective disability may be more influenced by psychosocial factors than disability measured during functional tasks, leading to under/over reporting, but further investigation is needed. This study sought to identify correlates of discrepancies between subjective and functional disability in two samples of patients with chronic pain.

Retrospective data was compiled from clinical records of 389 patients evaluated at a university multidisciplinary chronic spinal pain treatment program (52.7% men; 88.9% White, 9.8% Black; spinal …

Development And Initial Psychometric Evaluation Of A Culturally- Sensitive Beliefs About Personal Weight Survey, Stephanie Pickett

Wayne State University Dissertations

ABSTRACT

DEVELOPMENT AND INITIAL PSYCHOMETRIC EVALUATION OF

A CULTURALLY-SENSITIVE BELIEFS ABOUT PERSONAL WEIGHT SURVEY

by

STEPHANIE PICKETT

December 2012

Advisor: Dr. Rosalind Peters

Major: Nursing

Degree: Doctor of Philosophy

The purpose of this study was to develop and perform initial psychometric evaluation of an instrument that measures beliefs about personal weight in young African American women. Beliefs about personal weight were defined as a multidimensional concept consisting of the convictions regarding the descriptive characteristics, causal attributions, and consequences of one's personal weight. The theory of self-care (Orem, 2001) was used to conceptualize concepts and conceptual relationships.

The Beliefs about Personal …

Using The Protection Motivation Theory To Examine The Effects Of Obesity Fear Arousal On The Physical Activity Of Young Adult Female College Students, Bibia Renee Redd

Wayne State University Dissertations

The national rate of physical activity has been consistently declining while obesity and obesity-related illnesses are on the rise (French, Story, & Jeffrey, 2001; James, Leach, Kalamara, & Shayeghi, 2001; Malnick & Knobler, 2006). The current study employed a 2 (severity) x 2 (susceptibility) x 2 (intention implementation plan) x 3 (time) longitudinal within subject design examining the effects of the Protection Motivation Theory (Rogers, 1975, 1983) on the physical activity among 87 overweight young adult college females. A main effect was hypothesized for short-term severity, personal susceptibility, and the development of an intention implementation plan messages and an interaction …

Preterm Birth And The Perception Of Risk Among African Americans, Gwendolyn Simpson Norman

Wayne State University Dissertations

Background: African American women deliver preterm at a rate that is two to three times that of their white counterparts, and after decades of research, this disparity in birth outcomes still remains unexplained. While factors including income, education, neighborhood conditions, infection and stress have all been associated with prematurity, no combination of these factors has explained why the disparity persists. Recently, however, racism-specific stress has emerged as a possible factor contributing to this disparity. This study was designed to learn how preterm birth was explained by African Americans directly impacted by prematurity. Methods: Interviews were conducted with African American women …

A Microscopic And Stereological Study Of The Renal Artery Transitional Zone Of The Adult Male Dog, Fatemah Ramezani Nowrozani

Turkish Journal of Veterinary & Animal Sciences

A transitional zone in the dog renal artery was documented and its parameters were recorded: length and volumes of the luminal wall, tunica intima, tunica media, and tunica adventitia-as well as these parameters in the non-transitional zone of artery. Twelve normal adult male dogs were studied. The specimens were processed in the routine manner for light and electron microscopy. After the determination of transitional zone length by light microscope, for the stereological study each renal artery was divided into transitional and non-transitional zones, and paraffin blocks were prepared. It was established that the transitional zone contains parallel and continuous elastic …

Hyponatremia In The 2009 161-Km Western States Endurance Run, Martin D. Hoffman, Kristin J. Stuempfle, Ian R. Rogers, Louise B. Weschler, Tamara Hew-Butler

Health Sciences Faculty Publications

Purpose:To determine the incidence of exercise-associated hyponatremia (EAH), the associated biochemical measurements and risk factors for EAH, and whether there is an association between postrace blood sodium concentration ([Na⁺]) and changes in body mass among participants in the 2009 Western States Endurance Run, a 161-km mountain trail run.

Methods: Change in body mass, postrace [Na⁺], and blood creatine phosphokinase (CPK) concentration, and selected runner characteristics were evaluated among consenting competitors.

Results: Of the 47 study participants, 14 (30%) had EAH as defined by a postrace [Na⁺] /L. Postrace [Na^{+ …}

Polymorph Formation Of Tolfenamic Acid: An Investigation Of Pre-Nucleation Association, Alessandra Mattei

Theses and Dissertations--Pharmacy

The majority of pharmaceutical products are formulated as solids in the crystalline state. With the potential to exist in different crystalline modifications or polymorphs, each solid form bears its own physical and chemical properties, influencing directly bioavailability and manufacturability of the final dosage form. In view of the importance of crystalline form selection in the drug development process, it is imperative for pharmaceutical scientists to work arduously on various aspects of polymorphism, ranging from fundamental understanding of the phenomenon at the molecular level to practical utilization of a specific crystalline form. One common feature of organic crystals is the existence …

Comparing Functional Outcomes On Open Reduction And Internal Fixation For Acute Perilunate Dislocation And Fracture-Dislocations: A Systematic Review, Melissa Mundy Allen

MUSC Theses and Dissertations

Introduction: Outcomes based research on trauma-related orthopaedic injuries is imperative for gauging the effectiveness of current surgical procedures and thereby maximizing the patient's functional status. In patients sustaining perilunate dislocations (PLD) and fracture-dislocations (PLFD) following a traumatic fall on an outstretched hand, early open reduction and internal fixation (ORIF) is widely considered the standard of care for acute cases, but evidence supporting optimal techniques and materials is limited in a body of literature consisting mainly of small retrospective case series and expert opinion. The aims of this study were to compare functional outcomes of PLD and PLFD by surgical technique …

Differential Expression Of Metabolic Genes In Tumor And Stromal Components Of Primary And Metastatic Loci In Pancreatic Adenocarcinoma., Nina V. Chaika, Fang Yu, Vinee Purohit, Kamiya Mehla, Audrey J. Lazenby, Dominick J. Dimaio, Judy M. Anderson, Jen Jen Yeh, Keith R. Johnson, Michael A. Hollingsworth, Pankaj K. Singh

Journal Articles: Eppley Institute

BACKGROUND: Pancreatic cancer is the fourth leading cause of cancer related deaths in the United States with a five-year survival rate of 6%. It is characterized by extremely aggressive tumor growth rate and high incidence of metastasis. One of the most common and profound biochemical phenotypes of animal and human cancer cells is their ability to metabolize glucose at high rates, even under aerobic conditions. However, the contribution of metabolic interrelationships between tumor cells and cells of the surrounding microenvironment to the progression of cancer is not well understood. We evaluated differential expression of metabolic genes and, hence, metabolic pathways …