Medicine and Health Sciences Commons^™

Distinct Patterns Of Functional And Effective Connectivity Between Perirhinal Cortex And Other Cortical Regions In Recognition Memory And Perceptual Discrimination., Edward B O'Neil, Andrea B Protzner, Cornelia Mccormick, D Adam Mclean, Jordan Poppenk, Anthony D Cate, Stefan Köhler

Brain and Mind Institute Researchers' Publications

Traditionally, the medial temporal lobe (MTL) is thought to be dedicated to declarative memory. Recent evidence challenges this view, suggesting that perirhinal cortex (PrC), which interfaces the MTL with the ventral visual pathway, supports highly integrated object representations in recognition memory and perceptual discrimination. Even with comparable representational demands, perceptual and memory tasks differ in numerous task demands and the subjective experience they evoke. Here, we tested whether such differences are reflected in distinct patterns of connectivity between PrC and other cortical regions, including differential involvement of prefrontal control processes. We examined functional magnetic resonance imaging data for closely matched …

The Effects Of Adolescent Heavy Drinking On The Timing And Stability Of Cohabitation And Marriage, Lela Rankin Williams, Laura Wray-Lake, Eric Loken, Jennifer L. Maggs

CGU Faculty Publications and Research

Based on prospective British Cohort Study data, adolescent alcohol use predicted the timing and stability of committed partnerships between 16 and 34 years (n = 3278; 59% female). Propensity score methods balanced age 16 heavy drinkers (32.4%) and nonheavy drinkers on a range of relevant risk factors assessed in infancy and childhood. Adolescent heavy drinking predicted having ever cohabited, earlier transitions into cohabiting and marital relationships, more breakups, and an increased likelihood of divorce. Gender and social class moderated these relationships; heavy-drinking working-class males were especially likely to cohabit and to experience early entry into cohabitation and marriage. Implications …

Alternatives To Mixture Model Analysis Of Correlated Binomial Data, N. Rao Chaganty, Roy Sabo, Yihao Deng

Biostatistics Publications

While univariate instances of binomial data are readily handled with generalized linear models, cases of multivariate or repeated measure binomial data are complicated by the possibility of correlated responses. Likelihood-based estimation can be applied by using mixture distribution models, though this approach can present computational challenges. The logistic transformation can be used to bypass these concerns and allow for alternative estimating procedures. One popular alternative is the generalized estimating equation (GEE) method, though systematic errors can lead to infeasible correlation estimates or nonconvergence problems. Our approach is the coupling of quasileast squares (QLSs) method with a rarely used matrix factorization, …

Reduced Expression Of Inflammatory Genes In Deceased Donor Kidneys Undergoing Pulsatile Pump Preservation, Valeria Mas, Kellie J. Archer, Catherine I. Dumur, Mariano J. Scian, Jihee L. Suh, Anne L. King, Megan E. Wardius, Julie A. Straub, Marc P. Posner, Kenneth Brayman, Daniel Maluf

Biostatistics Publications

Background

The use of expanded criteria donor kidneys (ECD) had been associated with worse outcomes. Whole gene expression of pre-implantation allograft biopsies from deceased donor kidneys (DDKs) was evaluated to compare the effect of pulsatile pump preservation (PPP) vs. cold storage preservation (CSP) on standard and ECD kidneys.

Methodology/Principal Findings

99 pre-implantation DDK biopsies were studied using gene expression with GeneChips. Kidneys transplant recipients were followed post transplantation for 35.8 months (range = 24–62). The PPP group included 60 biopsies (cold ischemia time (CIT) = 1,367+/−509 minutes) and the CSP group included 39 biopsies (CIT = 1,022+/−485 minutes) (P

Conclusions/Significance …

A Confirmatory Factor Analysis Of The Metabolic Syndrome In Adolescents: An Examination Of Sex And Racial/Ethnic Differences, Matthew J. Gurka, Christa L. Ice, Shumei S. Sun, Mark D. Deboer

Biostatistics Publications

Objective The metabolic syndrome (MetS) is a cluster of clinical indices that signals increased risk for cardiovascular disease and Type 2 diabetes. The diagnosis of MetS is typically based on cut-off points for various components, e.g. waist circumference and blood pressure. Because current MetS criteria result in racial/ethnic discrepancies, our goal was to use confirmatory factor analysis to delineate differential contributions to MetS by sub-group.

Research Design and Methods Using 1999–2010 data from the National Health and Nutrition Examination Survey (NHANES), we performed a confirmatory factor analysis of a single MetS factor that allowed differential loadings across sex and race/ethnicity, …

Molecular Profiles Of Hcv Cirrhotic Tissues Derived In A Panel Of Markers With Clinical Utility For Hepatocellular Carcinoma Surveillance, Ricardo Gehrau, Kellie Archer, Valeria Mas, Daniel Maluf

Biostatistics Publications

Background

Early hepatocellular carcinoma (HCC) detection is difficult because low accuracy of surveillance tests. Genome-wide analyses were performed using HCV-cirrhosis with HCC to identify predictive signatures.

Methodology/Principal Findings

Cirrhotic liver tissue was collected from 107 HCV-infected patients with diagnosis of HCC at pre-transplantation and confirmed in explanted livers. Study groups included: 1) microarray hybridization set (n = 80) including patients without (woHCC = 45) and with (wHCC = 24) HCC, and with incidental HCC (iHCC = 11); 2) independent validation set (n = 27; woHCC = 16, wHCC = 11). Pairwise comparisons were performed using moderated t-test. FDR<1% was considered significant. L1-penalized logistic regression model was fit for woHCC and wHCC microarrays, and tested against iHCC. Prediction model genes were validated in independent set by qPCR. The genomic profile was associated with genetic disorders and cancer focused on gene expression, cell cycle and cell death. Molecular profile analysis revealed cell cycle progression and arrest at G2/M, but progressing to mitosis; unregulated DNA damage check-points, and apoptosis. The prediction model included 17 molecules demonstrated 98.6% of accuracy and correctly classified 6 out of 11 undiagnosed iHCC cases. The best model performed even better in the additional independent set.

Conclusions/Significances

The …

Patient- And Population-Level Health Consequences Of Discontinuing Antiretroviral Therapy In Settings With Inadequate Hiv Treatment Availability, April D. Kimmel, Stephen C. Resch, Xavier Anglaret, Norman Daniels, Sue J. Goldie, Christine Daniel, Angela Y. Wong, Kenneth A. Freedberg, Milton C. Weinstein

Health Policy Publications

Background

In resource-limited settings, HIV budgets are flattening or decreasing. A policy of discontinuing antiretroviral therapy (ART) after HIV treatment failure was modeled to highlight trade-offs among competing policy goals of optimizing individual and population health outcomes.

Methods

In settings with two available ART regimens, we assessed two strategies: (1) continue ART after second-line failure (Status Quo) and (2) discontinue ART after second-line failure (Alternative). A computer model simulated outcomes for a single cohort of newly detected, HIV-infected individuals. Projections were fed into a population-level model allowing multiple cohorts to compete for ART with constraints on treatment capacity. In the …

One Fish, Two Fish, Red Fish, Blue Fish: Effects Of Price Frames, Brand Names, And Choice Set Size In Medicare Part D Insurance Plan Decisions, Andrew J. Barnes, Yaniv Hanoch, Stacey Wood, Pi-Ju Liu, Thomas Rice

Health Policy Publications

Because many seniors choose Medicare Part D plans offering poorer coverage at greater cost, the authors examined the effect of price frames, brand names, and choice set size on participants' ability to choose the lowest cost plan. A 2×2×2 within-subjects design was used with 126 participants aged 18 to 91 years old. Mouselab, a web-based program, allowed participants to choose drug plans across eight trials that varied using numeric or symbolic prices, real or fictitious drug plan names, and three or nine drug plan options. Results from the multilevel models suggest numeric versus symbolic prices decreased the likelihood of choosing …

Parent’S Experiences During Their Infant’S Transition From Neonatal Intensive Care Unit To Home: A Qualitative Study, Sharon W. Hutchinson, Marydee A. Spillett, Mary Cronin

Center for Research Quality Publications

Limited literature exists which examines how parents of infants hospitalized in the Neonatal Intensive Care Unit (NICU) transition from their infant’s NICU hospital stay to home. This study examines the question, “What are the experiences of parents during their infant’s transition from the NICU to home? Grounded theory methods served as the paradigm to explore twelve NICU parents’ experiences during their infant’s transition. The basic social psychological process identified was “becoming a parent” which was based on the core problem “I’m not a parent.” Analysis of data contributed to a model described by the researchers as the resultant Model of …

Sequence Analysis Of The Human Virome In Febrile And Afebrile Children, Kristine M. Wylie, Kathie A. Mihindukulasuriya, Erica Sodergren, George M. Weinstock, Gregory A. Storch

Open Access Publications

No abstract provided.

A Tetravalent Dengue Nanoparticle Stimulates Antibody Production In Mice, Elisangela F. Silva, Mariana Orsi, Angela L. Andrade, Rosana Z. Domingues, Breno M. Silva, Helena Rc De Araujo, Paulo Fp Pimenta, Michael S. Diamond, Eliseu So Rocha, Erna G. Kroon, Luiz Cc Malaquias, Luiz Fl Coelho

Open Access Publications

No abstract provided.

Metabotropic Glutamate Receptor 5 (Mglur5) Regulates Bladder Nociception, Lara W. Crock, Kristina M. Stemler, David G. Song, Philip Abbosh, Sherri K. Vogt, Chang-Shen Qiu, H Henry Lai, Indira U. Mysorekar, Robert W. Gereau Iv

Open Access Publications

No abstract provided.

Optimal Strategy For Prophylactic Cranial Irradiation In Limited Stage Small Cell Lung Cancer, Edward Yu, Patricia Tai, Avi Assouline, Kurian Joseph

Data and Test Instruments

No abstract provided.

Stigma Of Mental Illness-2: Non-Compliance And Intervention, Amresh Srivastava

Data and Test Instruments

Stigma of Mental Illness-2: Non-compliance and Intervention Amresh Shrivastava*, Megan Johnston**, Yves Bureau*** ABSTRACT The consequences of stigma are preventable. We argue that individual attention should be provided to patients when dealing with stigma. Also, in order to deal with the impact of stigma on an individual basis, it needs to be assessed during routine clinical examinations, quantified and followed up to observe whether or not treatment can reduce its impact. A patient-centric anti-stigma programme that delivers the above is urgently needed. To this end, this review explores the experiences, treatment barriers and consequences due to stigma. We also offer …

The Life Of John Wishart (1850-1926): Study Of An Academic Surgical Career Prior To The Flexner Report., Emily Claydon, Vivian Mcalister

Data and Test Instruments

BACKGROUND: The 1910 Flexner Report on Medical Education in the United States and Canada is often taken as the point when medical schools in North America took on their modern form. However, many fundamental advances in surgery, such as anesthesia and asepsis, predated the report by decades. To understand the contribution of educators in this earlier period, we investigated the forgotten career of John Wishart, founding Professor of Surgery at Western University, London Ontario. METHODS: Archives at the University of Western Ontario, University of Toronto, London City Library, and Wellington County Museum were searched for material about Wishart and his …

Vestibular Stimulation Enhances Hippocampal Long-Term Potentiation Via Activation Of Cholinergic Septohippocampal Cells, Leung L. Stan

Physiology and Pharmacology Publications

Vestibular stimulation induced acetylcholine release in the hippocampus, and acetylcholine is known to facilitate long-term potentiation (LTP) in the hippocampus. Thus, we hypothesize that vestibular stimulation enhances LTP in CA1 in freely behaving rats, and this enhancement depends on the activation of septohippocampal cholinergic neurons. Field excitatory postsynaptic potentials were recorded in CA1 area of behaving rats following stimulation of the basal dendritic afferents. LTP was induced by a single stimulation train (100 pulses at 200 Hz) during passive whole-body rotation or during awakeimmobility. LTP induced during rotation was significantly larger than that induced during immobility. Pretreatment with cholinergic antagonist …

Durand Et Al 2012 Supplemental Figures, M. Durand, Svetlana V. Komarova, Ajay Bhargava, Keying Li, Cara Fiorino, Osama Maria, Noushin Nabavi, Morris Manolson, Rene Harrison, S. Jeffrey Dixon, Stephen Sims, Marcin Mizianty, Lukasz Kurgan, Sonia Haroun, Gilles Boire, Maria Lucena-Fernandes, Artur De Brum-Fernandes

Physiology and Pharmacology Publications

Objective. Our objective was to compare the osteoclastogenic capacity of peripheral blood mononuclear cells (PBMCs) from patients with osteoarthritis (OA) to that of PBMCs from self-reported normal individuals.

Methods. PBMCs from 140 patients with OA and 45 healthy donors were assayed for CD14⁺ expression and induced to differentiate into osteoclasts (OCs) over 3 weeks in vitro. We assessed the number of the OCs, their resorptive activity, OC apoptosis, and expression of the following cytokine receptors: receptor activator of nuclear factor κB (RANK), interleukin-1 receptor type I (IL-1R1) and IL-1R2. A ridge logistic regression classifier was developed …

Tracing Notochord-Derived Cells Using A Noto-Cre Mouse: Implications For Intervertebral Disc Development., Matthew R Mccann, Owen J Tamplin, Janet Rossant, Cheryle A Séguin

Physiology and Pharmacology Publications

Back pain related to intervertebral disc degeneration is the most common musculoskeletal problem, with a lifetime prevalence of 82%. The lack of effective treatment for this widespread problem is directly related to our limited understanding of disc development, maintenance and degeneration. The aim of this study was to determine the developmental origins of nucleus pulposus cells within the intervertebral disc using a novel notochord-specific Cre mouse. To trace the fate of notochordal cells within the intervertebral disc, we derived a notochord-specific Cre mouse line by targeting the homeobox gene Noto. Expression of this gene is restricted to the node and …

Fatigue In Cerebral Palsy: A Critical Review., Laura Kristine Brunton, Charles L Rice

Physical Therapy Publications

Objective: Fatigue contributes to the deterioration or cessation of walking ability in adults with cerebral palsy (CP). However, conflict exists as to its role. Studies involving functional tasks reported increased, and earlier onset of, fatigue in CP whereas laboratory studies have reported individuals with CP to be more fatigue resistant than their peers.

Methods: A critical review of the literature related to fatigue in CP was conducted.

Results: This review describes factors that contribute to the observed fatigue resistance in laboratory tasks and how a decreased force-production in CP can result in higher energy expenditure to perform the same amount …

Ua60/5 Wku Dental Hygiene Class Of 2012, Wku Dental Hygiene

WKU Administration Documents

Members of the 2012 dental hygiene class: Nikki Kennedy, class representative; Ashley O'Bannon, historian, Kelsey Morrison, secretary; Courtney Jamison, vice president; Alyssa Nantz, president; Sarah Lynch, treasurer; Hannah Murrey, historian; Alicia Azimipour, SADHA representative; Christie Woods, class representative; Lyndi Adler, Kelly Daughters, Casey Frost, Kayla Ginn, Deanna Gipson, Azra Hajrick, Kayla Jenkins, Samantha Johnson, Chad Jones, Brittney Kennedy, Kristen McCubbins, Jessica Mounce, Mikell Nelson, Morgan Poore, Whitney Rion, Devon Russell, Heather Sprouse and Traci Walker.

Comparative Study: The Impact Of The Sw3 Armband And Physical Activity Logbook In Promoting Physical Activity Adherence, Bernie Cunningham, Suzanne Kennedy, Joseph English, Humphrey Murphy

Irish Business Journal

The purpose of this study is to compare the impact of portable body sensing technology (SW3 Armband) to a traditional approach, a Physical Activity Logbook (PAL) in promoting physical activity adherence. Participant’s physical activity adherence levels were recorded over a six month period. The primary research involved a six month physical activity programme that commenced in October 2010 and finished in April 2011. Females (n=30) were recruited through a local newspaper and a radio advertisement. Participants were randomised to an Intervention Group (n=15) or a Control Group (n=15). To be eligible to participate in the study the following criteria applied: …

Plasticity Of Corticospinal Neural Control After Locomotor Training In Human Spinal Cord Injury, Maria Knikou

Publications and Research

Spinal lesions substantially impair ambulation, occur generally in young and otherwise healthy individuals, and result in devastating effects on quality of life. Restoration of locomotion after damage to the spinal cord is challenging because axons of the damaged neurons do not regenerate spontaneously. Body-weight-supported treadmill training (BWSTT) is a therapeutic approach in which a person with a spinal cord injury (SCI) steps on a motorized treadmill while some body weight is removed through an upper body harness. BWSTT improves temporal gait parameters, muscle activation patterns, and clinical outcome measures in persons with SCI. These changes are likely the result of …

Acoustic And Perceptual Analyses Of The Fundamental Frequencies Of African American And Caucasian Males And Females, Rose A. Vargo

ETD Archive

Normative data compiled by Hixon and Abbs (1980) continue to serve as guidelines for fundamental frequency (F0). These normative data were collected solely from Caucasian participants and may not accurately reflect norms for other ethnicities. According to published literature regarding pitch differences among racial groups, African Americans are believed to have a lower F0 than their Caucasian counterparts.This study investigated differences in F0 between African American and Caucasian young adults. Twenty adults between the ages of 18 and 30 were examined along three vocal parameters: sustained vowel phonation, a speaking task, and a reading task. Three experienced speech-language pathologists and …

Retrieval Of Episodic Versus Generic Information: Does The Order Of Recall Affect The Amount And Accuracy Of Details Reported By Children About Repeated Events?, Sonja P. Brubacher, Kim P. Roberts, Martine B. Powell

Psychology Faculty Publications

Children (N = 157) 4- to 8-years old participated 1 (single) or 4 times (repeated) in an interactive event. Across each condition, half were questioned a week later about the only or a specific occurrence of the event (Depth-first), and then about what usually happens. Half were prompted in the reverse order (Breadth-first). Children with repeated experience who first were asked about what usually happens reported more event-related information overall than those asked about an occurrence first. All children used episodic language when describing an occurrence; however children with repeated-event experience used episodic language less …

Virginia Dental Journal (Vol. 89, No. 2, 2012)

Virginia Dental Journal

No abstract provided.

Culture Ontogeny: Lifespan Development Of Religion And The Ethics Of Spiritual Counselling, Glen Milstein, Amy Manierre

Publications and Research

The counsellor has an ethical obligation to treat the whole person. Humans are cultural beings and the foundation of most cultures is religion. Religion and culture are received from our early relation~ ships and modified through later relationships across the lifespan. The paper introduces the term "culture ontogeny" to emphasize that this is a biological process wherein abstract ideas of culture and religion become material in the developing neurophysiology of each brain. A framework and methods are offered to examine the changing roles of religion in clients' emotional self~ structure, inclusive of those who describe themselves as spiritual, not religious. …

Understanding Research Impact, Kristi L. Holmes, Cathy C. Sarli

Becker Library Publications and Presentations

No abstract provided.

The Relationship Of Rehabilitation Counselors' Knowledge Of The Americans With Disabilities Act 1990, Attitudes Toward Reasonable Accommodation, And Job Development Efficacy, Joy Elizabeth Inniss-Johnson

Wayne State University Dissertations

The purpose of this research was to evaluate the relationship between the rehabilitation counselors' level of knowledge, attitudes towards reasonable accommodations and job development efficacy. The more knowledgeable rehabilitation counselors are about ADA, reasonable accommodations, and their attitude toward job development, the less likely their attitudes will be expected to fluctuate. In addition, there has been very little research in terms of evaluating rehabilitation counselor's level of job placement efficacy. A survey-based design was utilized to create both a quantitative description of knowledge of the ADA, beliefs about reasonable accommodations and job placement efficacy and qualitative information concerning the barriers …

It's A Birth Not A Procedure: An Ethnographic Study Of Intrauterine Fetal Death In A Labor And Delivery Unit Of An American Hospital Setting, Catherine Mcleod Griffin

Wayne State University Dissertations

Life transitions such as birth and death constitute a significant area within anthropological studies of ritual. It is important to investigate how individuals, groups, and communities organize around these events. Birth and death can be considered as rites of passage that mark key life transitions (van Gennep 1909/1960). Thus birth and death related rituals need to be investigated within the social and cultural context of American hospital settings to better understand the social organization of life, death, and personhood. In the American hospital setting, a reproductive loss at any gestational age receives the medical diagnostic label of an intrauterine fetal …

Motivating Adolescents To Chat For Health (Match): Improving Nutrition And Physical Activity In Urban Youth, Jaclyn Beth Issner

Wayne State University Dissertations

Adolescence represents a unique period of development that is filled with both opportunities and challenges. Choices and health patterns, such as sedentary activity or poor dietary intake, which are established during adolescence can set the stage for adulthood. Obesity in youth has emerged as a major health problem in the United States and across the globe (American Academy of Child and Adolescent Psychiatry, 2012). One way to help prevent obesity is by incorporating preventive intervention services into primary care health systems. The current study, therefore, evaluated the effects of a brief 1-session intervention delivered in a primary care setting in …