Medicine and Health Sciences Commons^™

Aging Contributes To Inflammation In Upper Extremity Tendons And Declines In Forelimb Agility In A Rat Model Of Upper Extremity Overuse., David M Kietrys, Ann E Barr-Gillespie, Mamta Amin, Christine K Wade, Steve N Popoff, Mary F Barbe

Department of Physical Therapy Faculty Papers

We sought to determine if tendon inflammatory and histopathological responses increase in aged rats compared to young rats performing a voluntary upper extremity repetitive task, and if these changes are associated with motor declines. Ninety-six female Sprague-Dawley rats were used in the rat model of upper extremity overuse: 67 aged and 29 young adult rats. After a training period of 4 weeks, task rats performed a voluntary high repetition low force (HRLF) handle-pulling task for 2 hrs/day, 3 days/wk for up to 12 weeks. Upper extremity motor function was assessed, as were inflammatory and histomorphological changes in flexor digitorum and …

Apo A1 Mimetic Rescues The Diabetic Phenotype Of Ho-2 Knockout Mice Via An Increase In Ho-1 Adiponectin And Lkbi Signaling Pathway, Jian Cao, Nitin Puri, Komal Sodhi, Lars Bellner, Nader G. Abraham, Attallah Kappas

Biochemistry and Microbiology

Insulin resistance, with adipose tissue dysfunction, is one of the hallmarks of metabolic syndrome. We have reported a metabolic syndrome-like phenotype in heme oxygenase (HO)-2 knockout mice, which presented with concurrent HO-1 deficiency and were amenable to rescue by an EET analog. Apo A-I mimetic peptides, such as L-4F, have been shown to induce HO-1 expression and decrease oxidative stress and adiposity. In this study we aimed to characterize alleviatory effects of HO-1 induction (if any) on metabolic imbalance observed in HO-2 KO mice. In this regard, HO-2^(−/−) mice were injected with 2 mg/kg/day L-4F, or vehicle, i.p., for …

Consumption Of High Ω-3 Fatty Acid Diet Suppressed Prostate Tumorigenesis In C3(1) Tag Mice, Juliana A. Akinsete, Gabriela Ion, Theodore R. Witte, W. Elaine Hardman

Biochemistry and Microbiology

Prostate cancer incidence and mortality are high in the Western world and high ω-6/ω-3 PUFA in the Western diet may be a contributing factor. We investigated whether changing from a diet that approximates ω-6 fat content of the Western diet to a high ω-3 fat diet at adulthood might reduce prostate cancer risk. Female SV 129 mice that had consumed a high ω-6 diet containing corn oil for 2 weeks were bred with homozygous C3(1)Tag transgenic male mice. All male offspring were weaned to the corn oil diet (CO) until postpuberty when half of the male offspring were transferred to …

2012 News, College Of Education And Human Development

Family and Consumer Sciences News

• Dietetics Program Reaccredited
• Faculty Member Appointed to Certified Family Life Educator Advisory Board
• Faculty Member in Dietetics Published
• Family Studies Faculty Present at Symposium
• Graduate Student Ambassador Announced
• Interior Design Students Collaborate to Redesign Kanley Chapel
• Manley Conducting Research
• Frazier Receives Grant from the North Central Regional Center for Rural Development
• FCS 5340 Consumer Behavior in the Fashion Environment
• Manley Awarded Grant
• Webber Article Published
• Zinser Visits Siberia
• National Council on Family Relations Chooses Book
• Colleagues International Working with the U.S. Department of State
• Commercial Interiors Design Challenge
• Dannison Completes Program Review
• Blaisure Co-Authors, Serving Military Families in the 21st …

The Role Of Medications In Predicting Activity Restriction Due To A Fear Of Falling, Dawn M. Guthrie, Paula C. Fletcher, Evelyn Williams, Nicole Boumans, John P. Hirdes

Kinesiology and Physical Education Faculty Publications

Objectives: To examine the role of medication use and other factors in predicting activity restriction due to a fear of falling (AR/FF). Methods: Older adults were assessed twice with the interRAI Community Health Assessment and the Berg Balance Scale (BBS). The main outcome was limiting going outdoors due to an AR/FF. Medications were recorded by trained assessors. Results: Participants (n=441) had a mean age of 80.3 (sd=7.1) years, most were aged 65+ (96.8%) and 29.3% reported activity restriction. Taking nervous system active or cardiovascular medications was associated with AR/FF. In a multivariate model, the main predictors were having 3+ comorbid …

Feasibility And Compliance With Daily Home Ecg Monitoring Of The Qt Interval In Heart Transplant Recipients, Erik V. Carter, Kathleen T. Hickey, David M. Pickham, Lynn V. Doering, Belinda Chen, Patricia R. E. Harris, Barbara J. Drew

Collected Faculty Scholarship

About 13% of adult heart transplant recipients do not survive to one year and a major cause of death is acute cellular allograft rejection.^1,2 According to the 2009 annual United States data published from the International Society for Heart Lung Transplantation Registry, acute rejection occurs in 25 – 35% of transplant recipients within the first year following transplant surgery.³ In order to detect the early stages of rejection so that more aggressive and early immunosuppressant therapy can be initiated, frequent biopsies of heart tissue are performed (typically, weekly or every other week in the first 3 months and …

Value Of A Graduate Gerontology Certificate Versus A Masters Degree, Janet S. Hahn

Academic Leadership Academy

The WMU Center for Gerontology was established in 2010 and builds on a strong tradition of gerontology education offered at WMU from the late 1970s to 2004. The undergraduate minor has been revised and is again offered. The previous graduate certificate in gerontology has not yet been reestablished.

This project sought to determine the relative value of a graduate certificate in gerontology vs. a masters degree in gerontology.

Ua12/4 Stall Street Journal, Vol. 4, Wku Health Services

WKU Administration Documents

Broadsides developed by WKU Health Services to convey public health information in students in bathroom stalls. Incomplete run.

The Role Of Cadmium And Nickel In Estrogen Receptor Signaling And Breast Cancer: Metalloestrogens Or Not?, Natalie B. Aquino, Mary B. Sevigny, Jackielyn Sabangan, Maggie C. Louie

Collected Faculty Scholarship

During the last half-century, incidences of breast cancer have increased globally. Various factors —genetic and environmental— have been implicated in the initiation and progression of this disease. One potential environmental risk factor that has not received a lot of attention is the exposure to heavy metals. While several mechanisms have been put forth describing how high concentrations of heavy metals play a role in carcinogenesis, it is unclear whether chronic, lowlevel exposure to certain heavy metals (i.e. cadmium and nickel), can directly result in the development and progression of cancer. Cadmium and nickel have been hypothesized to play a role …

Information Fusion And Quantum Logic In Family Medicine, F. Matthew Mihelic

Faculty Publications

A time-tested model for information fusion and analysis is provided by Family Medicine. Family Medicine is a discipline that operates in the realms of botJ1 technical and social sciences to analyze massive amounts of information from mulriple sources in order to make decisions that bring about tJie integration and coordination of interdisciplinary interventions involving scientific, psychological, and social aspects of medical care. This generalist function serves to lower the organizational entropy of complex systems and thereby improve efficiency while reducing ilie risk of catastrophic failure. Simply bringing a group of specialists together in one place does not bring about the …

Perceptual Enhancement Of Arteriovenous Malformation In Mri Angiography Displays, Abhari Kamyar, John S. H. Baxter, Roy Eagleson, Terry Peters, Sandrine De Ribaupierre

Anatomy and Cell Biology Publications

The importance of presenting medical images in an intuitive and usable manner during a procedure is essential. However, most medical visualization interfaces, particularly those designed for minimally-invasive surgery, suffer from a number of issues as a consequence of disregarding the human perceptual, cognitive, and motor system's limitations. This matter is even more prominent when human visual system is overlooked during the design cycle. One example is the visualization of the neuro-vascular structures in MR angiography (MRA) images. This study investigates perceptual performance in the usability of a display to visualize blood vessels in MRA volumes using a contour enhancement technique. …

Workplace Violence In The Healthcare Setting, Michelle M.M. Lenssen, Shirley Mccreery

Nursing Publications

Workplace Violence (WPV) is an all-encompassing term used to describe abusive behaviours directed at another with the intent to cause harm. Although the definition varies according to situations and practice settings, there is agreement that WPV has a negative impact on the health and wellbeing of nurses and the delivery of quality nursing care (Choiniere, MacDonnell, & Shamonda, 2010; Higgins & MacIntosh, 2010; Registered Nurses Association of Ontario [RNAO], 2008; Hsinag-Chu & Lee, 2011; Vessey, DeMarco, Gaffney, & Budin, 2009). The growing epidemic of violence in the workplace is of great concern for employees, employers and government agencies and is …

Uwomj Volume 81, Issue 2, Fall 2012, Western University

University of Western Ontario Medical Journal

Schulich School of Medicine & Dentistry

Uwomj Volume 81, Issue 1, Spring 2012, Western University

University of Western Ontario Medical Journal

Schulich School of Medicine & Dentistry

Uwomj Volume 81, Supplement S1, Summer 2012, Western University

University of Western Ontario Medical Journal

Schulich School of Medicine & Dentistry

Residual Renal Function Calculated From Serum Cystatin C Measurements And Knowledge Of The Weekly Standard Kt/V Urea, Shih Han Huang, Guido Filler, Robert M. Lindsay

Paediatrics Publications

No abstract provided.

Cardiac Failure Following Inadvertent Administration Of High-Dose Epinephrine Subcutaneously, Kim A. Tran, Douglas D. Fraser, Krista Hawrylyshyn, Kambiz Norozi

Paediatrics Publications

Our aim is to report the consequences of epinephrine toxicity leading to cardiac failure in a child and the successful management with dopamine and milrinone. A previously healthy 13-year-old girl undergoing a left tympanomastoidectomy was inadvertently administered 10 mL of 1:1000 epinephrine subcutaneously (0.175 mg/kg) on the left post auricular region in lieu of lidocaine. She developed sudden supraventricular tachycardia, hypertension and flash pulmonary edema. She was initially treated with propofol, nitrogycerin and increased peak end-expiratory pressure. Within 4 h, she remained tachycardic, but was hypotensive with an increased central venous pressure. Electrocardiogram and echocardiogram investigations showed ST changes indicative …

The Long And Short Of It: The Role Of Telomeres In Fetal Origins Of Adult Disease., Stephanie E Hallows, Timothy Regnault, Dean H Betts

Paediatrics Publications

Placental insufficiency, maternal malnutrition, and other causes of intrauterine growth restriction (IUGR) can significantly affect short-term growth and long-term health. Following IUGR, there is an increased risk for cardiovascular disease and Type 2 Diabetes. The etiology of these diseases is beginning to be elucidated, and premature aging or cellular senescence through increased oxidative stress and DNA damage to telomeric ends may be initiators of these disease processes. This paper will explore the areas where telomere and telomerase biology can have significant effects on various tissues in the body in IUGR outcomes.

Medical Physics Staffing For Radiation Oncology: A Decade Of Experience In Ontario, Canada., Jerry J. Battista Dr., Brenda G Clark, Michael S Patterson, Luc Beaulieu, Michael B Sharpe, L John Schreiner, Miller S Macpherson, Jacob Van Dyk

Oncology Publications

The January 2010 articles in The New York Times generated intense focus on patient safety in radiation treatment, with physics staffing identified frequently as a critical factor for consistent quality assurance. The purpose of this work is to review our experience with medical physics staffing, and to propose a transparent and flexible staffing algorithm for general use. Guided by documented times required per routine procedure, we have developed a robust algorithm to estimate physics staffing needs according to center-specific workload for medical physicists and associated support staff, in a manner we believe is adaptable to an evolving radiotherapy practice. We …

The Value Of Trust In Biotech Crop Development: A Case Study Of Bt Cotton In Burkina Faso., Obidimma Ezezika, Kathryn Barber, Abdallah S. Daar

Health Studies Publications

Background: Agricultural biotechnology public-private partnerships (PPPs) have been recognized as having great potential in improving agricultural productivity and increasing food production in sub-Saharan Africa. However, there is much public skepticism about the use of GM (genetically modified) crops and suspicion about private sector involvement in agbiotech projects. This case study sought to understand the role of trust in the Bacillus thuringiensis (Bt) cotton in Burkina Faso project by exploring practices and challenges associated with trust-building, and determining what makes these practices effective from the perspective of multiple stakeholders. Methods: We conducted semi-structured, face-to-face interviews to obtain stakeholders’ understanding of trust …

What Is Trust? Perspectives From Farmers And Other Experts In The Field Of Agriculture., Obidimma Ezezika, Jessica Oh

Health Studies Publications

Background

Agricultural biotechnology public-private partnerships (PPPs) have been recognized as necessary for improving agricultural productivity and increasing food production in sub-Saharan Africa. However, there are issues of public trust uniquely associated with PPPs involved in the development of genetically modified (GM) crops. Insight into how trust is understood by agbiotech stakeholders is needed to be able to promote and improve trust among actors comprising agbiotech PPPs. This study aimed to explore how stakeholders from the agricultural sector in sub-Saharan Africa understood the concept of trust in general as well as in the context of agbiotech PPPs.

Methods

Our data collection …

Strategies For Building Trust With Farmers: The Case Of Bt Maize In South Africa., Obidimma Ezezika, Robin Lennox, Abdallah S. Daar

Health Studies Publications

Background

In 1999, South Africa became the first African country to approve commercial production of subsistence genetically modified (GM) maize. The introduction of GM crop technology is often met with skepticism by stakeholders including farmers. The involvement of the private sector in this process can further breed mistrust or misperceptions. To examine these issues more closely, the objective of this case study was to understand the role of trust in the public-private partnership (PPP) arrangement involved in the development of Bacillus thuringiensis (Bt) maize in South Africa.

Methods

We conducted semi-structured, face-to-face interviews to obtain stakeholders’ understanding of trust in …

Building Effective Partnerships: The Role Of Trust In The Virus Resistant Cassava For Africa Project, Obidimma Ezezika, Justin Mabeya, Abdallah S. Daar

Health Studies Publications

Background: Virus Resistant Cassava for Africa (VIRCA) is an agricultural biotechnology public-private partnership (PPP) comprising the Donald Danforth Plant Sciences Center (DDPSC), National Agricultural Research Organization (NARO) of Uganda and Kenya Agricultural Research Institute (KARI). The project seeks to develop virus-resistant cassava for farmers in Kenya and Uganda. Yet, there is much public skepticism about the use of genetically modified (GM) crops and private sector involvement in Africa. This case study sought to understand the role of trust in the VIRCA partnership. Methods: We conducted semi-structured, face-to-face interviews to obtain stakeholders’ views on the challenges to, and practices for, building …

Harmonized Biosafety Regulations Are Key To Trust Building In Regional Agbiotech Partnerships: The Case Of The Bt Cotton Project In East Africa., Obidimma Ezezika, Justin Mabeya, Abdallah S. Daar

Health Studies Publications

Background

The Bacillus thuringiensis (Bt) cotton public-private partnership (PPP) project in East Africa was designed to gather baseline data on the effect of Bt cotton on biodiversity and the possibility of gene flow to wild cotton varieties. The results of the project are intended to be useful for Kenya, Uganda, and Tanzania when applying for biosafety approvals. Using the backdrop of the different biosafety regulations in the three countries, we investigate the role of trust in the Bt cotton partnership in East Africa.

Methods

Data were collected by reviewing relevant project documents and peer-reviewed articles on Bt cotton in Tanzania, …

Trait Stacking For Biotech Crops: An Essential Consideration For Agbiotech Development Projects For Building Trust., Obidimma Ezezika, Nadira Saleh, Abdallah S. Daar

Health Studies Publications

The development of agricultural biotechnology humanitarian projects for food security in the last five years has been rapid in developing countries and is expected to rise sharply over the coming years. An extremely critical issue in these projects involves building trust with the community and farmers they aim to serve. For the first time, our social audit engagement with one of these initiatives, the Water Efficient Maize for Africa project, has revealed that a critical but unrecognized component of building trust with farmers involves publicly addressing the concerns surrounding stacked trait crops. As a result, we argue in this article …

Building Effective Agbiotech Partnerships Founded On Trust: A Summary Of The Challenges And Practices In Sub-Saharan Africa, Obidimma Ezezika

Health Studies Publications

The potential for improving the efficiency and success of partnerships in agricultural biotechnology is contingent on the presence of trust. As Stephen Covey (2006) asserts in his book The Speed of Trust, trust is the basis of the new global economy and is an essential element of any successful organization [1]. The presence of trust is particularly important in public-private partnerships (PPPs), in which partners with varied interests, goals, and operating principles embark on complex tasks within innovative ventures. Even more crucial is the role of trust in the success of agbiotech initiatives led by PPPs. This is cited throughout …

Effectiveness Of The Coping Power Program In A Mexican-American Sample: Distinctive Cultural Considerations, Susan L. O'Donnell, Diomaris E. Jurecska, Robert Dyer

Aboriginal Policy Research Consortium International (APRCi)

This study responds to the challenges associated with delivering culturally sensitive and evidence-based treatment (EBT) to at-risk children. Current research supports group interventions based on the Coping Power Program (CPP) curriculum as EBT for improving the frequency of positive behaviors in children and adolescents. However, the effectiveness of the CPP in a Mexican-American sample has not been explored to date. This study investigated the effectiveness of the CPP delivered as a preventative intervention to Mexican-American adoles- cents in a rural school setting. A major emphasis is put on cultural sensitivity when working with this population. Cultural sensitivity is expressed by …

Using First Nations Children's Perceptions Of Food And Activity To Inform An Obesity Prevention Strategy, Ashlee-Ann E. Pigford, Noreen D. Willows, Nicholas L. Holt, Amanda S. Newton, Geoff D.C. Ball

Aboriginal Policy Research Consortium International (APRCi)

No abstract provided.

Sleep And Academic Performance In Indigenous Australian Children From A Remote Community: An Exploratory Studyjpc_2059 122, Patrick Cooper, Mark Kohler, Sarah Blunden

Aboriginal Policy Research Consortium International (APRCi)

Aim: Disruptions to sleep in childhood are associated with poor behaviour and deficits in academic performance and executive function. Although academic performance of indigenous children from remote communities in Australia is documented as well below that of non- indigenous children, the extent of sleep disruption and its contribution to academic performance among this population has not been assessed. This pilot study aimed to objectively assess the sleep of remote indigenous children and the association between sleep disruption and both academic performance and executive function.

Method: Twenty-one children from a remote Australian indigenous community aged 6–13 years wore actigraphy for two …

Management Of Type 2 Diabetes, Susan Harch, David Reeve, Carole Reeve

Aboriginal Policy Research Consortium International (APRCi)

Objective: This article describes the evaluation of a new model of partnership care using an audit cycle.

Results: Statistically significant improvements in foot examination, body mass index, urine albumin creatinine ratio, total cholesterol, triglycerides and visual acuity measurements were observed. Significant increases in the proportion of patients achieving cholesterol and triglycerides therapeutic targets occurred. Most other outcome indicators demonstrated a nonsignificant improvement, which may be due to the short time interval in the audit for potential change.

Conclusion: A dedicated chronic disease team and a clinical information system to coordinate culturally appropriate, multidisciplinary chronic disease care enables effective management of …