Medicine and Health Sciences Commons^™

Chronic Female Pelvic Pain; Part I: Clinical Pathoanatomy And Examination Of The Pelvic Region, G. Apte, P. Nelson, J. M. Brismée, G. S. Dedrick, R. Justiz, P. S. Sizer Jr.

Physical Therapy

No abstract provided.

The Effect Of Isometric Shoulder Internal And External Rotation On The Acromiohumeral Distance, C. White, G. S. Dedrick, P. S. Sizer, G. G. Apte, J. M. Brismée

Physical Therapy

No abstract provided.

Exposure To Ozone Modulates Human Airway Protease/Antiprotease Balance Contributing To Increased Influenza A Infection, M. J. Kesic, M. Myer, R. Bauer, I. Jaspers

Physician Assistant Program

No abstract provided.

Falls And Fall Protocols In The Care Of Older Adults: A Comparison Of Inpatient And Community Dwelling Veterans, Katy Torchia

Nursing Student Work

Project Title: Falls and Fall Protocols in the Care of Older Adults: A Comparison of Inpatient and Community Dwelling Veterans

Background: There is currently no literature that compares fall risks and fall prevention protocols among community dwelling and institutionalized elderly veterans.

Objective: This research project aims to eliminate this literature gap by utilizing a retrospective descriptive design to analyze existing health records of veterans from the St. Cloud Veterans Administration Health Care System (VAHS).

Method: This purpose of this study was to compare fall risk factors for inpatients and outpatient veterans. A repeated measure, retrospective record review …

Bioharness Multivariable Monitoring Device. Part I: Validity, James A. Johnstone, Paul A. Ford, Gerwyn Hughes, Tim Watson, Andrew T. Garrett

Kinesiology (Formerly Exercise and Sport Science)

The BioharnessTM monitoring system may provide physiological information on human performance but there is limited information on its validity. The objective of this study was to assess the validity of all 5 BioharnessTM variables using a laboratory based treadmill protocol. 22 healthy males participated. Heart rate (HR), Breathing Frequency (BF) and Accelerometry (ACC) precision were assessed during a discontinuous incremental (0- 12 km·h-1) treadmill protocol. Infra-red skin temperature (ST) was assessed during a 45 min-1 sub-maximal cycle ergometer test, completed twice, with environmental temperature controlled at 20 ±0.1 °C and 30 ± 0.1 °C. Posture (P) was assessed using a …

Bioharness Multivariable Monitoring Device. Part Ii: Reliability, James A. Johnstone, Paul A. Ford, Gerwyn Hughes, Tim Watson, Andrew T. Garrett

Kinesiology (Formerly Exercise and Sport Science)

The BioharnessTM monitoring system may provide physiological information on human performance but the reliability of this data is fundamental for confidence in the equipment being used. The objective of this study was to assess the reliability of each of the 5 BioharnessTM variables using a treadmill based protocol. 10 healthy males participated. A between and within subject design to assess the reliability of Heart rate (HR), Breathing Frequency (BF), Accelerometry (ACC) and Infra-red skin temperature (ST) was completed via a repeated, discontinuous, incremental treadmill protocol. Posture (P) was assessed by a tilt table, moved through 160o. Between subject data reported …

Center Of Pressure Excursion During The Golf Putting Stroke In Low, Mid And High Handicap Golfers, Ashley K. Richardson, Gerwyn Hughes, Andrew C.S. Mitchell

Kinesiology (Formerly Exercise and Sport Science)

Golf handicap is significantly correlated to putting performance with low handicap golfers (LH) demonstrating increased putting accuracy compared with high handicap golfers (HH). Smaller center of pressure excursion (CPE) during putting has been demonstrated by LH golfers, suggesting balance is important during successful putts. The aim of this study was to examine CPE in low, mid and high handicap golfers about the mediolateral axis (ML) and anteriorposterior axis (AP). Nineteen subjects participated in the study; subjects were split into LH, mid handicap and HH groups. Subjects completed five successful 2.5m putts, standing on an RS FootScan. The LH group demonstrated …

Field Based Reliability And Validity Of The Bioharness Multivariable Monitoring Device, James A. Johnstone, Paul A. Ford, Gerwyn Hughes, Tim Watson, Andrew C.S. Mitchell, Andrew T. Garrett

Kinesiology (Formerly Exercise and Sport Science)

The BioharnessTM device is designed for monitoring physiological variables in free-living situations but has only been proven to be reliable and valid in a laboratory environment. Therefore, this study aimed to determine the reliability and validity of the BioharnessTM using a field based protocol. Twenty healthy males participated. Heart rate (HR), breathing frequency (BF) and accelerometry (ACC) were assessed by simultaneous measurement of two BioharnessTM devices and a test-retest of a discontinuous incremental walk-jog-run protocol (4 – 11 km·h-1) completed in a sports hall. Adopted precision of measurement devices were; HR: Polar T31 (Polar Electro), BF: Spirometer (Cortex Metalyser), ACC: …

Shifts In The Architecture Of The Nationwide Health Information Network, L. Lenert, D. Sundwall, Michael E. Lenert

Media Studies

In the midst of a US $30 billion USD investment in the Nationwide Health Information Network (NwHIN) and electronic health records systems, a significant change in the architecture of the NwHIN is taking place. Prior to 2010, the focus of information exchange in the NwHIN was the Regional Health Information Organization (RHIO). Since 2010, the Office of the National Coordinator (ONC) has been sponsoring policies that promote an internetlike architecture that encourages point to-point information exchange and private health information exchange networks. The net effect of these activities is to undercut the limited business model for RHIOs, decreasing the likelihood …

Purging Of Memories From Conscious Awareness Tracked In The Human Brain, Benjamin Levy, Michael C. Anderson

Psychology

Understanding the neural basis of conscious experience and its regulation are fundamental goals of science. While recent research has made substantial progress in identifying the neural correlates of conscious experiences, it remains unclear how individuals exert control over the contents of awareness. In particular, can a memory that has entered the aware state be purged from consciousness if it is not currently desired? Here we tracked the correlates of consciousness in humans using functional magnetic resonance imaging and demonstrated the involvement of a downregulation mechanism that purges contents from conscious awareness. When individuals tried to prevent the retrieval of a …

Ensembles Of Human Mtl Neurons "Jump Back In Time" In Response To A Repeated Stimulus, M. W. Howard, Indre Viskontas, K. H. Shankar, I. Fried

Psychology

Episodic memory, which depends critically on the integrity of the medial temporal lobe (MTL), has been described as ‘‘mental time travel’’ in which the rememberer ‘‘jumps back in time.’’ The neural mechanism underlying this ability remains elusive. Mathematical and computational models of performance in episodic memory tasks provide a specific hypothesis regarding the computation that supports such a jump back in time. The models suggest that a representation of temporal context, a representation that changes gradually over macroscopic periods of time, is the cue for episodic recall. According to these models, a jump back in time corresponds to a stimulus …

On The Specificity Of Heparin/Heparan Sulfate Binding To Proteins. Anion-Binding Sites On Antithrombin And Thrombin Are Fundamentally Different, Philip D. Mosier, Chandravel Krishnasamy, Glen E. Kellogg, Umesh R. Desai

Medicinal Chemistry Publications

Background

The antithrombin–heparin/heparan sulfate (H/HS) and thrombin–H/HS interactions are recognized as prototypic specific and non-specific glycosaminoglycan (GAG)–protein interactions, respectively. The fundamental structural basis for the origin of specificity, or lack thereof, in these interactions remains unclear. The availability of multiple co-crystal structures facilitates a structural analysis that challenges the long-held belief that the GAG binding sites in antithrombin and thrombin are essentially similar with high solvent exposure and shallow surface characteristics.

Methodology

Analyses of solvent accessibility and exposed surface areas, gyrational mobility, symmetry, cavity shape/size, conserved water molecules and crystallographic parameters were performed for 12 X-ray structures, which include 12 …

Pyridoxal 5′-Phosphate Is A Slow Tight Binding Inhibitor Of E. Coli Pyridoxal Kinase, Mohini S. Ghatge, Roberto Contestabile, Martino L. Di Salvo, Jigar V. Desai, Amit Gandhi, Christina M. Camara, Rita Florio, Isabel N. Gonzalez, Alessia Parroni, Verne Schirch, Martin A. Safo

Medicinal Chemistry Publications

Pyridoxal 5′-phosphate (PLP) is a cofactor for dozens of B6 requiring enzymes. PLP reacts with apo-B6 enzymes by forming an aldimine linkage with the ε-amino group of an active site lysine residue, thus yielding the catalytically active holo-B6 enzyme. During protein turnover, the PLP is salvaged by first converting it to pyridoxal by a phosphatase and then back to PLP by pyridoxal kinase. Nonetheless, PLP poses a potential toxicity problem for the cell since its reactive 4′-aldehyde moiety forms covalent adducts with other compounds and non-B6 proteins containing thiol or amino groups. The regulation of PLP homeostasis in the cell …

Design, Synthesis, And In Vitro And In Vivo Biological Studies Of A 3′-Deoxythymidine Conjugate That Potentially Kills Cancer Cells Selectively, Qiong Wei, Dejun Zhang, Anna Yao, Liyi Mai, Zhiwei Zhang, Qibing Zhou

Medicinal Chemistry Publications

Thymidine kinases (TKs) have been considered one of the potential targets for anticancer therapeutic because of their elevated expressions in cancer cells. However, nucleobase analogs targeting TKs have shown poor selective cytotoxicity in cancer cells despite effective antiviral activity. 3′-Deoxythymidine phenylquinoxaline conjugate (dT-QX) was designed as a novel nucleobase analog to target TKs in cancer cells and block cell replication via conjugated DNA intercalating quinoxaline moiety. In vitro cell screening showed that dT-QX selectively kills a variety of cancer cells including liver carcinoma, breast adenocarcinoma and brain glioma cells; whereas it had a low cytotoxicity in normal cells such as …

Intimate Partner Violence And Alcohol Problems In Interethnic And Intra-Ethnic Couples, Karen G. Chartier, Raul Caetano

Social Work Publications

Despite the growing number of interethnic marriages in the U.S., few studies have examined intimate partner violence (IPV) in interethnic couples. This article examined past-year occurrences of IPV across interethnic and intra-ethnic couples and tested correlates of IPV specifically in interethnic couples. Data were from a national survey of couples 18 years of age and older from the 48 contiguous states. Interethnic couples (n = 116) included partners from different ethnic backgrounds, including black-white, Hispanic-white, and black-Hispanic couples. White (n = 555), black (n = 358), and Hispanic (n = 527) intra-ethnic couples included partners with …

Evaluation Of A Revised Curriculum: A Four-Year Qualitative Study Of Student Perceptions, Sharon K. Lanning, Angela P. Wetzel, Meredith B. Baines, B. Ellen Byrne

Periodontics Publications

Following curricular revisions at the Virginia Commonwealth University School of Dentistry, this longitudinal study was designed to determine students' perceptions of their educational experience in the revised curriculum. A SWOT (Strengths, Weaknesses, Opportunities, and Threats) open-ended response questionnaire was administered to students in the class of 2011 (N=89) in January of each academic year, 2008 through 2011, followed by focus groups three months prior to graduation. The overall response rate for the questionnaire was 69 percent, and a total of fourteen students participated in four focus groups. Cumulatively, 1,382 responses (SWOT=984 and focus groups=398) were qualitatively analyzed, and five themes …

Geriatric Home Makeover, Edward F. Ansello

Director's Editorials from Age in Action

Houses pose substantial risks for falling. Over half of all falls by older adults happen in their homes. Reducing hazards in the home addresses just one set of contributing risk factors involved in older adults falling.

Shared Resistance To Aging And Als In Neuromuscular Junctions Of Specific Muscles, Gregorio Valdez, Juan C. Tapia, Jeff W. Lichtman, Michael A. Fox, Joshua R. Sanes

Anatomy and Neurobiology Publications

Normal aging and neurodegenerative diseases both lead to structural and functional alterations in synapses. Comparison of synapses that are generally similar but respond differently to insults could provide the basis for discovering mechanisms that underlie susceptibility or resistance to damage. Here, we analyzed skeletal neuromuscular junctions (NMJs) in 16 mouse muscles to seek such differences. We find that muscles respond in one of three ways to aging. In some, including most limb and trunk muscles, age-related alterations to NMJs are progressive and extensive during the second postnatal year. NMJs in other muscles, such as extraocular muscles, are strikingly resistant to …

Spxa1 Involved In Hydrogen Peroxide Production, Stress Tolerance And Endocarditis Virulence In Streptococcus Sanguinis, Lei Chen, Xiuchun Ge, Xiaojing Wang, Jenishkumar R. Patel, Ping Xu

Philips Institute for Oral Health Research Publications

Streptococcus sanguinis is one of the most common agents of infective endocarditis. Spx proteins are a group of global regulators that negatively or positively control global transcription initiation. In this study, we characterized the spxA1 gene in S. sanguinis SK36. The spxA1 null mutant displayed opaque colony morphology, reduced hydrogen peroxide (H2O2) production, and reduced antagonistic activity against Streptococcus mutans UA159 relative to the wild type strain. The ΔspxA1 mutant also demonstrated decreased tolerance to high temperature, acidic and oxidative stresses. Further analysis revealed that ΔspxA1 also exhibited a ~5-fold reduction in competitiveness in an animal model of …

Augmenter Of Liver Regeneration (Alr) Promotes Liver Outgrowth During Zebrafish Hepatogenesis, Yan Li, Muhammad Farooq, Donglai Sheng, Chanchal Chandramouli, Tian Lan, Nilesh K. Mahajan, R. Manjunatha Kini, Yunhan Hong, Thomas Lisowsky, Ruowen Ge

Biochemistry and Molecular Biology Publications

Augmenter of Liver Regeneration (ALR) is a sulfhydryl oxidase carrying out fundamental functions facilitating protein disulfide bond formation. In mammals, it also functions as a hepatotrophic growth factor that specifically stimulates hepatocyte proliferation and promotes liver regeneration after liver damage or partial hepatectomy. Whether ALR also plays a role during vertebrate hepatogenesis is unknown. In this work, we investigated the function of alr in liver organogenesis in zebrafish model. We showed that alr is expressed in liver throughout hepatogenesis. Knockdown of alr through morpholino antisense oligonucleotide (MO) leads to suppression of liver outgrowth while overexpression of alr promotes liver growth. …

Cholesterol Side-Chain Cleavage Gene Expression In Theca Cells: Augmented Transcriptional Regulation And Mrna Stability In Polycystic Ovary Syndrome, Jessica K. Wickenheisser, Jessica M. Biegler, Valen L. Nelson-Degrave, Richard S. Legro, Jerome F. Strauss Iii, Jan M. Mcallister

Obstetrics and Gynecology Publications

Hyperandrogenism is characteristic of women with polycystic ovary syndrome (PCOS). Ovarian theca cells isolated from PCOS follicles and maintained in long-term culture produce elevated levels of progestins and androgens compared to normal theca cells. Augmented steroid production in PCOS theca cells is associated with changes in the expression of genes for several steroidogenic enzymes, including CYP11A1, which encodes cytochrome P450 cholesterol side-chain cleavage. Here, we further examined CYP11A1 gene expression, at both the transcriptional and post-transcriptional level in normal and PCOS theca cells propagated in long-term culture utilizing quantitative RT-PCR, functional promoter analyses, and mRNA degradation studies. The minimal …

Localization And Sub-Cellular Shuttling Of Htlv-1 Tax With The Mirna Machinery, Rachel Van Duyne, Irene Guendel, Zachary Klase, Aarthi Narayanan, William Coley, Elizabeth Jaworski, Jessica Roman, Anastas Popratiloff, Renaud Mahieux, Kylene Kehn-Hall, Fatah Kashanchi

Microbiology, Immunology, and Tropical Medicine Faculty Publications

The innate ability of the human cell to silence endogenous retroviruses through RNA sequences encoding microRNAs, suggests that the cellular RNAi machinery is a major means by which the host mounts a defense response against present day retroviruses. Indeed, cellular miRNAs target and hybridize to specific sequences of both HTLV-1 and HIV-1 viral transcripts. However, much like the variety of host immune responses to retroviral infection, the virus itself contains mechanisms that assist in the evasion of viral inhibition through control of the cellular RNAi pathway. Retroviruses can hijack both the enzymatic and catalytic components of the RNAi pathway, in …

The Role Of Ezh2 In The Regulation Of The Activity Of Matrix Metalloproteinases In Prostate Cancer Cells., Yong Jae Shin, Jeong-Ho Kim

Biochemistry and Molecular Medicine Faculty Publications

Degradation of the extracellular matrix (ECM), a critical step in cancer metastasis, is determined by the balance between MMPs (matrix metalloproteinases) and their inhibitors TIMPs (tissue inhibitors of metalloproteinases). In cancer cells, this balance is shifted towards MMPs, promoting ECM degradation. Here, we show that EZH2 plays an active role in this process by repressing the expression of TIMP2 and TIMP3 in prostate cancer cells. The TIMP genes are derepressed by knockdown of EZH2 expression in human prostate cancer cells but repressed by overexpression of EZH2 in benign human prostate epithelial cells. EZH2 catalyzes H3K27 trimethylation and subsequent DNA methylation …

Patient Engagement: Patients As Partners In Their Own Health Care, Nancy L. Falk, Mary Jean Schumann

Nursing Faculty Posters and Presentations

No abstract provided.

Chapter 12: Drinking, In Intimacy And Community In A Changing World: Sikaiana Life 1980-1993, William Donner

Sikaiana Ethnography

The role or alcohol consumption among the Sikaiana, Solomon Islands. This is an account from 1980 to 1993 and the Sikaiana do not drink as heavily at present (2020). The chapter discusses the manner in which alcohol was integrated into Sikaiana life from 1980-1993.

A related site can be found at www.sikaianaarchives.com

Synapsis: Philadelphia Campus (2012), Philadelphia College Of Osteopathic Medicine

All Yearbooks

This yearbook includes American Medical Association (AMA), American Medical Student Association (AMSA), American Medical Women's Association (AMWA), Association of the American College of Osteopathic Family Physicians (ACOFP), Asian Pacific American Medical Student Association (APAMSA), Robert Berger, DO Pediatrics Society, Christian Medical Dental Association (CMDA), Kappa Sigma Phi, KSPh, (ΚΣΦ) Women's Osteopathic Society, Medical Students for Choice, Military Osteopathic Physicians and Surgeons (AMOPS), Muslim Student Medical Association, National Latino Health Organization (NLHO), Phi Sigma Gamma PSG, (ΦΣΓ) Fraternity, Physicians for Human Rights Club, Physicians for Social Responsibility Club, Sigma Sigma Phi SSPh, (ΣΣΦ) Honorary Osteopathic Service Fraternity, Student American Osteopathic Academy …

Improved Self-Control Associated With Using Relatively Large Amounts Of Glucose: Learning Self-Control Is Metabolically Expensive, Matthew T. Gailliot

Faculty Publications

The current study examined whether changes in glucose during a self-control task would predict changes in self-control performance later on. Participants attended two experimental sessions, spaced two weeks apart. During each session, they had their glucose measured, completed the Stroop task as a measure of self-control, and then had their glucose measured again. Larger decreases in glucose (from before to after the Stroop task) during the first session predicted larger increases in improvement on the Stroop task during the second session, in the form of increased speed. Learning self-control might benefit from using larger amounts of glucose. Learning self-control is …

Mortality Salience And Metabolism: Glucose Drinks Reduce Worldview Defense Caused By Mortality Salience, Matthew T. Gailliot

Faculty Publications

The current work tested the hypothesis that a glucose drink would reduce worldview defense following mortality salience. Participants consumed either a glucose drink or placebo, wrote about either death or dental pain, and then completed a measure of worldview defense (viewing positively someone with pro-US views and viewing negatively someone with anti-US views). Mortality salience increased world- view defense among participants who consumed a placebo but not among participants who consumed a glucose drink. Glucose might reduce defensiveness after mortality salience by increasing the effectiveness of the self-controlled suppression of death-related thought, by providing resources to cope with mortality salience …

Breaking The Rules: Low Trait Or State Self-Control Increases Social Norm Violations, Matthew T. Gailliot, Seth A. Gitter, Michael D. Baker, Roy F. Baumeister

Faculty Publications

Two pilot and six studies indicated that poor self-control causes people to violate social norms and rules that are effortful to follow. Lower trait self-control was associated with a greater willingness to take ethical risks and use curse words. Participants who completed an initial self-control task that reduced the capacity for self-control used more curse words and were more willing to take ethical risks than participants who completed a neutral task. Poor self-control was also associated with violating explicit rules given by the experimenter. Depleting self-control resources in a self-control exercise caused participants subsequently to talk when they had been …

Two-Dimensional Blood Flow Velocity Estimation Using Apparent Speckle Pattern Angle Dependence On Scan Velocity, Tiantian Xu, Gregory R. Bashford

Biomedical Imaging and Biosignal Analysis Laboratory

An algorithm which measures the lateral component of blood flow velocity was developed in our previous studies based on the increase in speckle size due to relative motion between moving scatterers and spatial rate of scanner A-line acquisition (scan velocity). In this paper, the apparent dominant angle of the speckle pattern in a straight vessel was investigated and a new method of two-dimensional blood flow velocity estimation is introduced. Different scan velocities were used for data acquisition from blood flow traveling at an angle relative to the ultrasound beam. The apparent angle of the speckle pattern changes with different scan …