Medicine and Health Sciences Commons^™

Identification Of Membrane-Bound Variant Of Metalloendopeptidase Neurolysin (Ec 3.4.24.16) As The Non-Angiotensin Type 1 (Non-At1), Non-At2 Angiotensin Binding Site, Naomi J. Wangler, Kira L. Santos, Ines Schadock, Fred K. Hagen, Emanuel Escher, Michael Bader, Robert C. Speth, Vardan T. Karamyan

HPD Articles

Recently, we discovered a novel non-angiotensin type 1 (non-AT1), non-AT2 angiotensin binding site in rodent and human brain membranes, which is distinctly different from angiotensin receptors and key proteases processing angiotensins. It is hypothesized to be a new member of the renin-angiotensin system. This study was designed to isolate and identify this novel angiotensin binding site. An angiotensin analog, photoaffinity probe 125I-SBpa-Ang II, was used to specifically label the non-AT1, non-AT2 angiotensin binding site in mouse forebrain membranes, followed by a two-step purification procedure based on the molecular size and isoelectric point of the photoradiolabeled binding protein. Purified samples were …

Ada News - 01/02/2012, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Network Modulation During Complex Syntactic Processing, Dirk B. Den Ouden, Dorothee Saur, Wolfgang Mader, Björn Schelter, Sladjana Lukic, Eisha Wali, Jens Timmer, Cynthia K. Thompson

Faculty Publications

Complex sentence processing is supported by a left-lateralized network including inferior frontal cortex and posterior superior temporal cortex. This study investigates the pattern of connectivity and information flow within this network. We used fMRI BOLD data derived from 12 healthy participants reported in and earlier study (Thompson, C. K., Den Ouden, D. B., Bonakdarpour, B., Garibaldi, K. & Parrish, T. B. (2010b). Neural plasticity and treatment-induced recovery of sentence processing in agrammatism. Neuropsychologia, 48(11), 3211-3227) to identify activation peaks associated with object-cleft over syntactically less complex subject-cleft processing. Directed Partial Correlation Analysis was conducted on time series extracted from …

Striving For Brave New Brains, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Enhanced Interleukin-1 Activity Contributes To Exercise Intolerance In Patients With Systolic Heart Failure, Benjamin W. Van Tassell, Ross A. Arena, Stefano Toldo, Eleonora Mezzaroma, Tania Azam, Ignacio M. Seropian, Keyur Shah, Justin Canada, Norbert F. Voelkel, Charles A. Dinarello, Antonio Abbate

Pharmacotherapy and Outcomes Science Publications

Background

Heart failure (HF) is a complex clinical syndrome characterized by impaired cardiac function and poor exercise tolerance. Enhanced inflammation is associated with worsening outcomes in HF patients and may play a direct role in disease progression. Interleukin-1β (IL-1β) is a pro-inflammatory cytokine that becomes chronically elevated in HF and exerts putative negative inotropic effects.

Methods and Results

We developed a model of IL-1β-induced left ventricular (LV) dysfunction in healthy mice that exhibited a 32% reduction in LV fractional shortening (P

Conclusions

These findings suggest that IL-1β activity contributes to poor exercise tolerance in patients with systolic HF and identifies …

Atorvastatin With Or Without An Antibody To Pcsk9 In Primary Hypercholesterolemia, Eli M. Roth, James M. Mckenny, Corinne Hanotin, Gaelle Asset, Evan A. Stein

Pharmacotherapy and Outcomes Science Publications

Background

Serum proprotein convertase subtilisin/kexin 9 (PCSK9) binds to low-density lipoprotein (LDL) receptors, increasing the degradation of LDL receptors and reducing the rate at which LDL cholesterol is removed from the circulation. REGN727/SAR236553 (designated here as SAR236553), a fully human PCSK9 monoclonal antibody, increases the recycling of LDL receptors and reduces LDL cholesterol levels.

Methods

We performed a phase 2, multicenter, double-blind, placebo-controlled trial involving 92 patients who had LDL cholesterol levels of 100 mg per deciliter (2.6 mmol per liter) or higher after treatment with 10 mg of atorvastatin for at least 7 weeks. Patients were randomly assigned to …

Resemblance Of Symptoms For Major Depression Assessed At Interview Versus From Hospital Record Review, Ying Chen, Haimin Li, Yihan Li, Dong Xie, Zhiyang Wang, Fuzhong Wang, Yuan Shen, Sulin Ni, Yan Wei, Yanhua Liu, Lanfen Liu, Chengge Gao, Jun Liu, Lijuan Yan, Gang Wang, Keqing Li, Qiang He, Tiehang Liu, Jinbei Zhang, Yan Ren, Qunli Du, Jing Tian, Honghui Chen, Yanfang Luo, Fengzhi Zhang, Guangwei Sun, Chunjie Shan, Xueyi Wang, Yutang Zhang, Xiaoqin Weng, Yunchun Chen, Zhen Kang, Jing Guan, Yiping Chen, Shenxun Shi, Kenneth S. Kendler, Jonathan Flint, Hong Deng

Psychiatry Publications

Background

Diagnostic information for psychiatric research often depends on both clinical interviews and medical records. Although discrepancies between these two sources are well known, there have been few studies into the degree and origins of inconsistencies.

Principal findings

We compared data from structured interviews and medical records on 1,970 Han Chinese women with recurrent DSM-IV major depression (MD). Correlations were high for age at onset of MD (0.93) and number of episodes (0.70), intermediate for family history (+0.62) and duration of longest episode (+0.43) and variable but generally more modest for individual depressive symptoms (mean kappa = 0.32). Four factors …

Comparison Of Statistical Tests For Association Between Rare Variants And Binary Traits, Silviu-Alin Bacanu, Matthew R. Nelson, John C. Whittaker

Psychiatry Publications

Genome-wide association studies have found thousands of common genetic variants associated with a wide variety of diseases and other complex traits. However, a large portion of the predicted genetic contribution to many traits remains unknown. One plausible explanation is that some of the missing variation is due to the effects of rare variants. Nonetheless, the statistical analysis of rare variants is challenging. A commonly used method is to contrast, within the same region (gene), the frequency of minor alleles at rare variants between cases and controls. However, this strategy is most useful under the assumption that the tested variants have …

Network-Assisted Investigation Of Combined Causal Signals From Genome-Wide Association Studies In Schizophrenia, Peilin Jia, Lily Wang, Ayman H. Fanous, Carlos N. Pato, Todd L. Edwards, Zhongming Zhao

Psychiatry Publications

With the recent success of genome-wide association studies (GWAS), a wealth of association data has been accomplished for more than 200 complex diseases/traits, proposing a strong demand for data integration and interpretation. A combinatory analysis of multiple GWAS datasets, or an integrative analysis of GWAS data and other high-throughput data, has been particularly promising. In this study, we proposed an integrative analysis framework of multiple GWAS datasets by overlaying association signals onto the protein-protein interaction network, and demonstrated it using schizophrenia datasets. Building on a dense module search algorithm, we first searched for significantly enriched subnetworks for schizophrenia in each …

Student Perception Of Clicker Usage In Nursing Education, Pamela Fifer

Faculty Publications - College of Nursing

Nurse educators must explore innovative ways to engage students and stimulate learning. Student response system (SRS) technology is one tool educators can use to increase participation, provide immediate feedback, and encourage critical thinking. This study evaluated perceptions of first-year nursing students using SRS technology. The findings support the use of SRS technology as a positive pedagogical approach to incorporate in teaching associate degree nursing students.

It’S My Body: The Biomedical Ethics Of Cell And Organ Harvest, Christina Perri

Common Reading Essay Contest Winners

First Place

Jax Archives Box Inventory List, The Jackson Laboratory Archives

Box Inventory

No abstract provided.

Low Dose Nicotine And Antagonism Of Β2 Subunit Containing Nicotinic Acetylcholine Receptors Have Similar Effects On Affective Behavior In Mice, Shawn M. Anderson, Darlene H. Brunzell

Pharmacology and Toxicology Publications

Nicotine leads to both activation and desensitization (inactivation) of nicotinic acetylcholine receptors (nAChRs). This study tested the hypothesis that nicotine and a selective antagonist of β2*nAChRs would have similar effects on affective behavior. Adult C57BL/6J male mice were tested in a conditioned emotional response (CER) assay which evaluates the ability of an aversive stimulus to inhibit goal-directed behavior. Mice lever-pressed for a saccharin reinforcer according to a variable schedule of reinforcement during sessions in which two presentations of a compound light/tone conditioned stimulus (CS) co-terminated with a 0.1 or 0.3 mA, 0.5 s footshock unconditioned stimulus (US). During testing in …

The Impact Of A Naturalistic Stressor On Spontaneous Alternation Behavior: A New Animal Model Of Ocd, Christina Finch

Behavioral Neuroscience Honors Papers

Over the past few decades, various animal models of obsessive compulsive disorder (OCD) have been developed. Similarly, various stressors have been used throughout animal research. The Spontaneous Alternation Behavioral (SAB) model is a well-established model of OCD while 2,5-dihydro-2,4,5-trimethylthiazoline (TMT) has recently become a popular naturalistic stressor. This study linked the two together, thus modeling the effect of stress on OCD behaviors. After living in an enriched or standard environment for 3 weeks, male Sprague-Dawley rats were exposed to either TMT or no odor, and then were examined in the SAB task. Unlike what was hypothesized, the enriched environment proved …

Chemical Hazards Emergency Medical Management (Chemm), Emily Vardell

Faculty Research, Publications, and Presentations

The Chemical Hazards Emergency Medical Management (CHEMM) website from the National Library of Medicine is designed for first responders and medical providers who are planning for and responding to chemical hazards events. It includes pages tailored to the individual interests of specific groups, including first responders, health care providers, mental health professionals, toxicologists, and more. The featured decision support system CHEMM Intelligent Syndromes Tool allows users to identify the chemical a patient was exposed to in a mass casualty event.

Visualdx: A Visual Diagnostic Decision Support Tool, Emily Vardell, Carmen Bou-Crick

Faculty Research, Publications, and Presentations

VisualDx is a clinical decision support tool that uses images and searchable clinical features to assist physicians in the diagnostic decision-making process. VisualDx is a database of more than 24,000 high quality images covering a wide variety of conditions and drug eruptions. In addition, VisualDX integrates within both UpToDate and many electronic medical records and features a mobile version. This column includes a sample search and a review of the features of VisualDx.

Group Purchasing By A Regional Academic Medical Library Consortium: How Scamel Made It Work, Joann Van Schaik

Faculty Research, Publications, and Presentations

Cooperative academic library organizations have existed in the United States at least since 1933. Many of these organizations which formed prior to the advent of electronic resources have added group negotiating, licensing, and purchasing to their activities. One of those consortia is the South Central Academic Medical Libraries (SCAMeL). The steps this organization took to succeed in collaborative electronic resource collection development and the possibilities for its future are discussed.

Part 1 Making Bibliographic Researchers More Efficient, Vedana Vaidhyanathan, Mary Moore Phd, Kimberly A. Loper, Joann Van Schaik, David Goolabsingh

Faculty Research, Publications, and Presentations

Researcher-writers need integrated systems to help them increase productivity. These systems should enhance the intellectual aspects of writing such as analysis and synthesis of existing research, while lessening the burden of more routine, but still necessary duties, such as bibliographic editing. Although a robust, fully integrated system for researcher-writer support does not exist, new resources are moving closer to that goal. Third party programs that connect bibliographic search results to the full text PDFs of cited articles can save time and effort and result in discoveries that may not have been obvious using approaches and processes of the past. Questions …

Statistical Insight: A Review, Emily Vardell, Yanira Garcia-Barcena

Faculty Research, Publications, and Presentations

Statistical Insight is a database that offers the ability to search across multiple sources of data, including the federal government, private organizations, research centers, and international intergovernmental organizations in one search. Two sample searches on the same topic, a basic and an advanced, were conducted to evaluate the database.

Hospice Nurse Perceptions Of Constipation And Attitudes Towards Abdominal Massage, Elizabeth Everette

Nursing Theses and Capstone Projects

Constipation is a prevalent symptom in the hospice population, negatively effecting quality of life for patients. Constipation is frequently overlooked, undiagnosed, and untreated by healthcare providers. The role of the hospice nurse is ideal for managing the symptom of constipation with traditional and alternative therapies. Literature review reveals very limited research on constipation and hospice patients, and alternative therapies for constipation. No research was found regarding nurse attitudes towards alternative therapies, such as abdominal massage for constipation. This research study tested the following hypothesis: Hospice nurses perceive constipation as significantly impacting the quality of life for the hospice patient, and …

Nurses' Perceptions Of Intradermal Sterile Water Injection Use In Labor, Abby E. Garlock

Nursing Theses and Capstone Projects

Nurses' perceptions of barriers may influence the type of pain control options offered to women in labor. While effective in relieving low-back pain associated with labor, nurses rarely utilize intradermal sterile water injections for women during labor. Using the Nurses' Perceptions of the Use of Intradermal Sterile Water Injections in Labor survey, labor nurses identified barriers to offering intradermal sterile water injections during labor. Individual and institutional characteristics were associated with higher perceived barriers. Nurses who reported working primarily day shift ( t = 2.06, p = .05), higher epidural rates ( r = .45, p = .018), and higher …

Incivility Among Nurses - Prevalence And Impact, Nadin Knippschild

Nursing Theses and Capstone Projects

Incivility, horizontal violence, uncivil behavior or bullying are only a few terms used to describe the conduct one individual may display toward another that are undesirable in healthcare organizations and consequently gained the attention of regulatory agencies, such as The Joint Commission. Incivility adversely affects healthy work environments, impedes with patient safety and collaboration, has negative financial implications for organizations, and represents an ethical concern in nursing. The purpose of this study was to identify the overall prevalence as well as prevalence based on work areas. In addition, further aims were to examine the likelihood of the study participants calling …

Attitudes And Practices Of Perioperative Nurses Effecting The Election Of Wearing Protection From Occupational Radiation Exposure, Jane Leonard

Nursing Theses and Capstone Projects

Health effects from exposure to radiation are unpredictable. On a daily bases, nurses working in the perioperative setting are exposed to medical x-rays (ionizing radiation) and are vulnerable to its carcinogenic effects. Regardless of the potential health consequences, the use of protective equipment remains inconsistent among perioperative nurses. Most research studies regarding nurses' occupational health risks either failed to include or separate radiation exposure from chemicals and blood borne pathogens. The purpose of this study was to examine the relationship between the attitudes and practices of perioperative nurses that influence their decisions to wear or not wear radiation protection equipment …

Workplace Violence: Emergency Department Versus Medical Surgical Nurses, Dakeita K. Roakes

Nursing Theses and Capstone Projects

The purpose of this study is to answer the following question: Does a registered nurses department, medical-surgical versus emergency department, change the amount of workplace violence they may experience? To accomplish this, a cross sectional descriptive study using an anonymous web-based Workplace Violence questionnaire survey by Wolters Kluwer Health was used to collect data from nurses working on medical-surgical units and in the emergency department at the facility. The findings indicate more physical violence with more frequent or occasional occurrences in emergency departments. The medical-surgical nurses reported more intimidation or emotional violence and never experience workplace violence.

The Impact Of Simulation-Based Learning Experience On Critical Thinking Acquisition, Candice Rome

Nursing Theses and Capstone Projects

The purpose of this comparative experimental project was to compare the impact of simulation-based learning experiences to traditional clinical rotations on critical thinking acquisition of associate nursing students within a maternal-child course. Innovative pedagogies have been integrated in nursing programs to augment inadequate clinical placement and instructor availabilities. A longitudinal convenience sample of 45 second year associate level nursing students enrolled in a maternal-child course was utilized. Four experimental groups, 24 students were exposed to an eight-hour simulation-based learning experience in place of one clinical rotation. During the eight hour simulation day, students participated in three various maternal-child centered simulations. …

Botanical Medicine: The Need For Better Quality Research, Antoine Al-Achi

Pharmaceutical Sciences

No abstract provided.

Food Store Environment Modifies Intervention Effect On Fruit And Vegetable Intake Among Low-Income Women In North Carolina, Alison A. Gustafson, Joseph Sharkey, Carmen D. Samuel-Hodge, Jessica C. Jones-Smith, Jianwen Cai, Alice S. Ammerman

Dietetics and Human Nutrition Faculty Publications

Background. The aim of the study is to determine how the food store environment modifies the effects of an intervention on diet among low-income women. Study Design. A 16-week face-to-face behavioral weight loss intervention was delivered among low income midlife women. Methods. The retail food environment for all women was characterized by (1) the number and type of food stores within census tracts; (2) availability of healthy foods in stores where participants shop; (3) an aggregate score of self-reported availability of healthy foods in neighborhood and food stores. Statistical Analyses. Multivariable linear regression was used to …

Ethnic And Immigration Status Differences On Child Indicators Of Health For European Americans And Latinos, Christina Granillo, David V. Chavez, Donna M. Garcia, Kelly Campbell

Psychology Faculty Publications

This study examined the effects of ethnicity and immigration status on subjective and objective health (Body Mass Index; BMI) for Latino and European American children. Social identity and comparison theories were used to frame the investigation. Southern California parents were randomly selected to complete a telephone interview about their children’s health yielding a sample of 165 European American and 152 Latino participants. Compared to European Americans, Latinos evidenced poorer subjective and objective health. Latino children who had a caregiver who was a citizen had better subjective health than Latino children whose caregiver was not a citizen. BMI was correlated with …

Hiv/Aids Stigmatization Among Oromo Immigrant Congregations In The Twin Cities : A Call For Biblical And Theological Response, Fikru Andea Eticha

Master of Arts Theses

No abstract provided.

Advancing Employee Engagement Through The Development And Responsible Use Of An Internal Social Media Wiki, Marci Timlin

Nursing Posters

The purpose of this Evidence-based practice project is to increase employee engagement on the Surgical Care Unit through the use of social media. The fundamental reason for the project is to increase cohesion among employees by increasing communication, team building, and personal relationships.