Medicine and Health Sciences Commons^™

The Effect Of Ice Pack On Lumbar Range Of Motion In Patients With Low Back Pain And Lumbar Sacralization, Shih-Chieh Lin, Yi-Chun Hung, Yin-Chou Lin, Wei-Han Chang, Yu-Tsai Tu, Shih-Wei Chou

Rehabilitation Practice and Science

Purpose: This research was designed to investigate the short-term effect of an ice pack on lumbar range of motion in patients. Patients with low back pain caused by sacralized fifth lumbar spine were selected after clinical diagnosis.Method: Twenty-four subjects were recruited for this study. Twelve subjects with low back pain who were diagnosed with sacralized fifth lumbar spine were selected as the experimental group, and twelve healthy subjects were selected as the control group. The age, body height, and weight of the patients in the two groups were compared. Measurements of lumbar range of motion were used as the pretest …

The Results Of The 2010 New System For Assessment Of Disability In Hualien County: A Preliminary Study, Pao Huang, Pei-Lin Wu, Chih-Cheng Fan, Chung-Chao Liang

Rehabilitation Practice and Science

Objective: This study uses the assessment results from the new system of the disability assessment schedule to investigate the relationships between the short version of the WHODAS 2.0 and the body functions, activities and participation, and environmental factors in this schedule. The influence of using this assessment schedule on changes in disability levels is analyzed.Method: In total, this study recruits 148 individuals with disabilities in Hualien County as cases for study. The new system assessment schedule from the ICF's promotion program is adopted to perform an assessment. The assessment items include body functions, activities and participation, environmental factors, and the …

Mirror Image Artifact Of Sonography Mimicking Intraosseous Tumor: A Casereport, Zong-Han Yang, Lu-Wen Chen, Chia-Chieh Wu, Chung-Che Lin

Rehabilitation Practice and Science

Although mirror-image artifacts of soft tissue sonography are not common, they produce phantom pictures and may lead to misdiagnosis. Relevant literature on mirror-image artifacts, even casereports, are rare. We described a 70-year-old female initially having a painless, immovable nodule with an insidious onset on her right anterior middle leg. After she received an initial physical examination and a radiographic approach, musculoskeletal sonography disclosed an oval non-compressible hypoechoic tumor, which seemed to invade the bony cortex medial to her tibia crest. A real, dome-shaped tumor above the tibia bone with an intraosseous mirror-image artifact was detected after MRI study, and the …

Application Of Digital Volume Pulse Analysis In Patients With Spinal Cord Injury, Wei-Lun Tsai, Alice May-Kuen Wong, Yu-Cheng Pei, Yu-Ru Lin, Yu-Hsin Liao, Shu-Chun Huang

Rehabilitation Practice and Science

Orthostatic hypotension is a common complication following spinal cord injury (SCI). However, an easy method to quantify the degree of vasomotor impairment below the level of injury is lacking. We postulated that SCI patients with different sympathetic reserves exhibited different digital volume pulse contours. Thirty-one patients with high chronic SCI (above the T6 neurologic level) and 28 low-level SCI patients (below T6) were recruited. Thirty-two age- and BMI-matched healthy participants were enrolled in the control group. All participants were positioned on a tilting table for five minutes in each of the following: supine rest (SR), 60-degree head-up tilt (HUT), and …

Related Factors In Children With The Motor Development Delay And Flat Feet, Hui-Wen Cheng, Chin-Kai Lin, Ching-Shiang Chi, Mei-Hua Tang

Rehabilitation Practice and Science

Condition of flat feet is a common among preschool children. Clinical studies show that children with developmental delays have problems similar to flat feet, perhaps of a more and complicated nature compared to the normal children. As literature on flat feet in children with developmental delays was hardly available, the main topic of this study was to explore factors associated with flat feet in preschool children with developmental delays, and the effect of flat feet on lower-extremity functions.The 50 participants in this study were selected from 88 children aged 4-6 years with motor delay. They were divided into two groups …

Ankle Joint Flexibility, Muscle Strength, And Unilateral Stance Balance Of Elite Men's High School Basketball Players: A Preliminary Study, Meng-Tai Chen, Chia-Hong Chen, Wai-Keung Lee, Chia-Ming Lin

Rehabilitation Practice and Science

Objective: This study aimed to investigate ankle dorsiflexion flexibility, ankle invertor and evertor muscle isokinetic performance and balance during unilateral stance in high school division I basketball players. This study also aimed to investigate the similarities and differences between the dominant and non-dominant leg of the basketball players.Method: Thirty-six high school division I basketball players were recruited. The exclusion criteria were sustaining injuries in the lower limbs within the past 3 months and experiencing residual symptoms of pain in the ankle joints. Further, the study was conducted such that the test performances were not affected by the training that the …

Ipsilateral Hemiparesis Caused By Supratentorial Stroke: Two Casereports, Yen-Chung Chen, Ta-Sen Wei, Chih-Lin Chen

Rehabilitation Practice and Science

A common symptom that occurs after strokes is impaired contralesional motor function and contralateral limbs weakness. Such weakness of the limbs is often found in a supratentorial stroke. Two patients with ipsilateral limbs weakness after supratentorial stroke events were reported. One was a recurrent ischemic stroke in the right frontal lobe with right hemiparesis; the other was a new ischemic stroke in the right thalamus with right hemiparesis. There were few reported cases of ipsilateral hemiparesis caused by a supratentorial cerebral lesion. The mechanism of such symptoms may be related to 1. Activation and cortical reorganization within the motor areas …

Potentials And Limitations Of Real-Time Elastography For Prostate Cancer Detection: A Whole-Mount Step Section Analysis., Daniel Junker, Georg Schäfer, Friedrich Aigner, Peter Schullian, Leo Pallwein-Prettner, Jasmin Bektic, Wolfgang Horninger, Ethan J Halpern, Ferdinand Frauscher

Department of Radiology Faculty Papers

OBJECTIVES: To evaluate prostate cancer (PCa) detection rates of real-time elastography (RTE) in dependence of tumor size, tumor volume, localization and histological type.

MATERIALS AND METHODS: Thirdy-nine patients with biopsy proven PCa underwent RTE before radical prostatectomy (RPE) to assess prostate tissue elasticity, and hard lesions were considered suspicious for PCa. After RPE, the prostates were prepared as whole-mount step sections and were compared with imaging findings for analyzing PCa detection rates.

RESULTS: RTE detected 6/62 cancer lesions with a maximum diameter of 0-5 mm (9.7%), 10/37 with a maximum diameter of 6-10 mm (27%), 24/34 with a maximum diameter …

Kabuki Syndrome: A Casereport, Hsin-I Wu, Shih-Jay Tzeng, Chang-Hsien Yu

Rehabilitation Practice and Science

Kabuki syndrome (KS) is a rare congenital disorder characterized by distinctive facial features, skeletal anomalies, dermatoglyphic abnormalities, mild to moderate mental retardation and postnatal growth deficiency. Although first reported in Japan, it has been recognized in other parts of the world. The present case with KS is a five-year-old boy. Because of his pervasive developmental delay, he received care in rehabilitation programs hosted by our hospital. He had prominent ears, depressed nasal tip, long palpebral fissures, and long eyelashes. The common features of KS in him are postnatal growth retardation, moderate mental retardation, scoliosis, cleft palate, flat feet, fifth finger …

Preparasi, Karakterisasi Dan Evaluasi Pelepasan Obat Dari Beads Kalsium Alginat Deksametason Dengan Metode Gelasi Ionik, Christye Aulia, Joshita Djajadisastra

Majalah Ilmu Kefarmasian

Inflammatory Bowel Disease (IBD) is a disease of inflammation in the colon. Targeted delivery systems for the treatment of IBD is designed to increase the drug concentration in the local tissue. Dexamethasone is a drug having anti-inflammatory and antifibrosis effects which is used to repair scar tissue arising from postoperative IBD. This research purpose to create calciumalginate beads dexamethasone to be released only in the colon. Beads were made by using sodium-alginate and Ca2+ as crosslinker by ionic gelation method, with ratio between sodium alginate-dexamethasone (3:1). A concentration of solution sodium alginate 3 % b/v with variation concentration of crosslinker …

Medical School Watercooler Newsletter - December 30, 2012, Lindsey Lyle

Watercooler Newsletter

This is the December 30, 2012 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• USA Physicians Named Best Doctors
• USA College of Medicine Mourns Loss of Dr. Susan Gibson

Successfully Climbing The "Stairs": Surmounting Failed Translation Of Experimental Ischemic Stroke Treatments, Michael Kahle, Gregory J. Bix

Sanders-Brown Center on Aging Faculty Publications

The Stroke Therapy Academic Industry Roundtable (STAIR) provided initial (in 1999) and updated (in 2009) recommendations with the goal of improving preclinical stroke therapy assessment and to increase the translational potential of experimental stroke treatments. It is important for preclinical stroke researchers to frequently consider and revisit these concepts, especially since promising experimental stroke treatments continue to fail in human clinical trials. Therefore, this paper will focus on considerations for several key aspects of preclinical stroke studies including the selection and execution of the animal stroke model, drug/experimental treatment administration, and outcome measures to improve experimental validity and translation potential. …

Regulation Of The Mouse And Human Β-Globin Genes By Krüppel Like Transcription Factors Klf1 And Klf2, Yousef N. Alhashem

Theses and Dissertations

Krüppel-like factors KLF1 and KLF2 are closely related transcription factors with three zinc finger domains in their carboxy-termini. KLF1 (erythroid Krüppel-like factor, or EKLF) plays essential roles in embryonic and adult erythropoiesis. KLF2 is a positive regulator of the mouse and human embryonic β- globin genes. KLF1 and KLF2 have overlapping roles in embryonic erythropoiesis, as demonstrated using single and double knockout (KO) mouse models. Ablation of the KLF1 or KLF2 gene causes embryonic lethality, and double KO embryos are more anemic and die sooner than either single KO. We have shown that KLF1 and KLF2 positively regulate the human …

Circularized Synthetic Oligodeoxynucleotides Serve As Promoterless Rna Polymerase Iii Templates For Small Rna Generation In Human Cells, Christine I. Seidl, Lodoe Lama, Kevin Ryan

Publications and Research

Synthetic RNA formulations and viral vectors are the two main approaches for delivering small therapeutic RNA to human cells. Here we report findings supporting an alternative strategy in which an endogenous human RNA polymerase (RNAP) is harnessed to make RNA hairpin-containing small RNA from synthetic single-stranded DNA oligonucleotides. We report that circularizing a DNA template strand encoding a pre-microRNA hairpin mimic can trigger its circumtranscription by human RNAP III in vitro and in human cells. Sequence and secondary structure preferences that appear to promote productive transcription are described. The circular topology of the template is required for productive transcription, at …

Applications Of Weak Ion Association Between Symmetrical Tetraalkylammonium Ions And Inorganic Anions, Julius Mbuna

Journal of Humanities and Social Sciences

Interactions between tetraalkylammonium ions and inorganic anions can be used to develop methods of separation for inorganic anions by any separation technique. From the ion association and thermodynamic data, capillary electrophoretic (CE) technique can be easily designed to effect separation of inorganic anions samples. Using CE mode such as capillary zone electrophoresis (CZE) to investigate weak ion association between inorganic anions and the pairing cations also furnishes data to evaluate association theories like Bjerrum’s theory. Findings show that the increase in association constant Kass as the dielectric constant decreased is not exponential as maintained by the Bjerrum’s theory. The increase …

Relationship Between Listening Comprehension And Signal-To-Noise Ratio Loss In Children, Juli Beth Junkersfeld

Student Theses and Dissertations

This study compared the listening comprehension skills and signal-to-noise ratio hearing loss of third grade children. A pool of potential participants was formed based on their scores earned on the listening comprehension subtest of the Group Reading Assessment and Diagnostic Examination (GRADE). Twenty-one third grade students were available for participation in this study. In order to accomplish the purposes of this study, the same 21 children were grouped by three separate criteria: listening comprehension scores, sentence comprehension scores, and hearing sensitivity. The instrument used in this study was the Quick Speech In Noise (QuickSIN), an adaptive test that uses a …

Acute Hypersensitivity Of Pluripotent Testicular Cancer-Derived Embryonal Carcinoma To Low-Dose 5-Aza Deoxycytidine Is Associated With Global Dna Damage-Associated P53 Activation, Anti-Pluripotency And Dna Demethylation, Bijesh K. Biswal, Maroun J. Beyrouthy, Mary P. Hever-Jardine, David Armstrong, Craig R. Tomlinson, Brock C. Christensen, Carmen J. Marsit, Michael J. Spinella

Dartmouth Scholarship

Human embryonal carcinoma (EC) cells are the stem cells of nonseminoma testicular germ cells tumors (TGCTs) and share remarkable similarities to human embryonic stem (ES) cells. In prior work we found that EC cells are hypersensitive to low nanomolar doses of 5-aza deoxycytidine (5-aza) and that this hypersensitivity partially depended on unusually high levels of the DNA methyltransferase, DNMT3B. We show here that low-dose 5-aza treatment results in DNA damage and induction of p53 in NT2/D1 cells. In addition, low-dose 5-aza results in global and gene specific promoter DNA hypomethylation. Low- dose 5-aza induces a p53 transcriptional signature distinct from …

Parallel Ngo Networks For Hiv Control: Risks And Opportunities For Ngo Contracting., Shehla Zaidi, Xaher Gul, Noureen Aleem Nishtar

Community Health Sciences

Policy measures for preventive and promotive services are increasingly reliant on contracting of NGOs. Contracting is a neo-liberal response relying on open market competition for service delivery tenders. In contracting of health services a common assumption is a monolithic NGO market. A case study of HIV control in Pakistan shows that in reality the NGO market comprises of parallel NGO networks having widely different service packages, approaches and agendas. These parallel networks had evolved over time due to vertical policy agendas. Contracting of NGOs for provision of HIV services was faced with uneven capacities and turf rivalries across both NGO …

On The Interplay Of Telomeres, Nevi And The Risk Of Melanoma, Clara Bodelon, Ruth M. Pfeiffer, Valentina Bollati, Julien Debbache, Donato Calista, Paola Ghiorzo, Maria Concetta Fargnoli, Giovanna Bianchi-Scarra, Ketty Peris, Mirjam Hoxha, Amy Hutchinson, Laura Burke, Shenying Fang, Margaret A. Tucker, Alisa M. Goldstein, Jeffrey E. Lee, Qingyi Wei, Sharon A. Savage, Xiaohong R. Yang, Christopher Amos, Maria Teresa Landi

Dartmouth Scholarship

The relationship between telomeres, nevi and melanoma is complex. Shorter telomeres have been found to be associated with many cancers and with number of nevi, a known risk factor for melanoma. However, shorter telomeres have also been found to decrease melanoma risk. We performed a systematic analysis of telomere-related genes and tagSNPs within these genes, in relation to the risk of melanoma, dysplastic nevi, and nevus count combining data from four studies conducted in Italy. In addition, we examined whether telomere length measured in peripheral blood leukocytes is related to the risk of melanoma, dysplastic nevi, number of nevi, or …

Hyperosmolar Therapy For Raised Intracranial Pressure., Ethan A Benardete

Department of Neurosurgery Faculty Papers

No abstract provided.

The 'Art' Of Medicine: Building A Caring Relationship With Clients, Lisa Barkley

UCF Forum

On the first day of school each year at the UCF College of Medicine, Dean Deborah German asks our incoming class of students what they think makes a “good doctor.”

Integrated Services Post (Posyandu) As Sociocultural Approach For Primary Health Care Issue, Oedojo Soedirham

Kesmas

Kelahiran posyandu pada tahun 1980-an merupakan usaha pemerintah Indonesia untuk meningkatkan status kesehatan masyarakat, mengikuti panggilan internasional, Deklarasi Alma Ata (Kazakhstan) tentang kesehatan masyarakat tahun 1978. Konsep kunci deklarasi tersebut adalah partisipasi masyarakat. Di Indonesia, partisipasi masyarakat disebut “gotong royong”. Masyarakat memainkan peran penting dalam meningkatkan kesehatan masing-masing. Untuk melibatkan masyarakat dalam kesehatan masyarakat, relawan harus direkrut dan dilatih untuk mengenal isu-isu kesehatan masyarakat dasar. Gagasan mengenai relawan yang disebut kader (village health worker) tersebut diajukan agar relawan sebagai bagian dari masyarakat dapat lebih mudah menyampaikan program-program kesehatan karena lebih dekat dibandingkan pejabat kesehatan masyarakat. Di dalam artikel ini dibahas …

Kondisi Sosial Ekonomi Dan Stres Pada Wanita Hipertensi Anggota Majelis Taklim, Anna Fitriani

Kesmas

Proporsi hipertensi pada wanita selalu lebih tinggi dengan peningkatan usia populasi. Penelitian ini membahas hipertensi dan faktor risiko pada 105 wanita dewasa anggota Majelis Taklim Al-Amin Cilandak, Jakarta Selatan. Penelitian observasional dengan desain studi potong lintang ini dilatarbelakangi oleh hasil Riset Kesehatan Dasar (Riskesdas) 2007 dengan metode analisis uji Chi Square. Populasi target adalah seluruh anggota majelis taklim di Jakarta Selatan dengan sampel anggota Majelis Taklim Al-Amin di Kecamatan Cilandak yang datang pada saat pengambilan data. Hasil penelitian menunjukkan bahwa prevalensi hipertensi sebesar 41,7% lebih tinggi daripada provinsi DKI Jakarta (28,6%) dan angka nasional 2007 (31,7%). Hipertensi pada penelitian ini …

Perbedaan Gender Pada Kejadian Sindrom Metabolik Pada Penduduk Perkotaan Di Indonesia, Krisnawaty Bantas, Hari Koesnanto Yoseph, Budi Moelyono

Kesmas

Sindrom Metabolik (SM) merupakan faktor risiko penting penyakit kardiovaskuler yang merupakan penyebab utama kematian di Indonesia. Perbedaan gender pada SM berkontribusi terhadap perbedaan gender pada penyakit kardiovaskuler. Penelitian ini bertujuan mengetahui prevalensi dan risiko SM berdasarkan gender di perkotaan Indonesia menggunakan data Riset Kesehatan Dasar 2007 dan menggunakan rancangan penelitian potong lintang. Populasi penelitian terdiri dari 13.262 orang pria dan wanita yang tidak hamil berusia lebih dari 15 tahun yang bermukim di daerah perkotaan. Variabel penelitian meliputi variabel dependen sindrom metabolik. Variabel independen utama adalah gender dan variabel kovariat yang lain adalah level 1 (umur, status perkawinan, pendidikan, stres, merokok, …

Humor As A Teaching Strategy: The Effect On Students' Educational Retention And Attention In A Nursing Baccalaureate Classroom, Mohammed Ahmed Alkhattab

Nursing Master Theses

With the rapid development in nursing education systems, nurse educators struggle to find effective teaching strategies for their students. Using humor as a teaching strategy with nursing students can be helpful in improving many areas of their education. The review of literature showed a lack of studies on the effect of using humor in nursing education. The purpose of this study is to explore the effect of using humor as a teaching strategy on the educational retention and attention of sophomore nursing students. The setting for this study was a college of nursing at a Midwestern university. The participants were …

Genomic Loss Of Tumor Suppressor Mirna-204 Promotes Cancer Cell Migration And Invasion By Activating Akt/Mtor/Rac1 Signaling And Actin Reorganization, Saadi J. Imam, Jason R. Plyler, Hima Bansal, Suresh Prajapati, Sanjay Bansal, Jennifer Rebeles, Jeffrey S. Dome, +12 Additional Authors

Pediatrics Faculty Publications

Increasing evidence suggests that chromosomal regions containing microRNAs are functionally important in cancers. Here, we show that genomic loci encoding miR-204 are frequently lost in multiple cancers, including ovarian cancers, pediatric renal tumors, and breast cancers. MiR-204 shows drastically reduced expression in several cancers and acts as a potent tumor suppressor, inhibiting tumor metastasis in vivo when systemically delivered. We demonstrated that miR-204 exerts its function by targeting genes involved in tumorigenesis including brain-derived neurotrophic factor (BDNF), a neurotrophin family member which is known to promote tumor angiogenesis and invasiveness. Analysis of primary tumors shows that increased expression …

The Gifts, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Multiple Subject Barycentric Discriminant Analysis (Musubada): How To Assign Scans To Categories Without Using Spatial Normalization, Hervé Abdi, Lynne J. Williams, Andrew C. Connolly, M. Ida Gobbini

Dartmouth Scholarship

We present a new discriminant analysis (DA) method called Multiple Subject Barycentric Discriminant Analysis (MUSUBADA) suited for analyzing fMRI data because it handles datasets with multiple participants that each provides different number of variables (i.e., voxels) that are themselves grouped into regions of interest (ROIs). Like DA, MUSUBADA (1) assigns observations to predefined categories, (2) gives factorial maps displaying observations and categories, and (3) optimally assigns observations to categories. MUSUBADA handles cases with more variables than observations and can project portions of the data table (e.g., subtables, which can represent participants or ROIs) on the factorial maps. Therefore MUSUBADA can …

Evaluating Changes In Radiation Treatment Volumes From Post-Operative To Same-Day Planning Mri In High-Grade Gliomas., Colin E Champ, Joshua Siglin, Mark V Mishra, Xinglei Shen, Maria Werner-Wasik, David W Andrews, Sonal U Mayekar, Haisong Liu, Wenyin Shi

Department of Radiation Oncology Faculty Papers

BACKGROUND: Adjuvant radiation therapy (RT) with temozolomide (TMZ) is standard of care for high grade gliomas (HGG) patients. RT is commonly started 3 to 5 weeks after surgery. The deformation of the tumor bed and brain from surgery to RT is poorly studied. This study examined the magnitude of volume change in the postoperative tumor bed and the potential impact of RT planning.

METHOD AND MATERIALS: This study includes 24 patients with HGG who underwent craniotomy and adjuvant RT with TMZ at our institution. All patients had immediate postoperative MRI and repeat MRI during the day of RT simulation. Gross …

A Comparison Of Professional Traders And Psychopaths In A Simulated Non-Zero Sum Game, Thomas Noll Jd, Md, Jérôme Endrass Ppd, Pascal Scherrer, Astrid Rossegger Ppd, Frank Urbaniok Ppd, Andreas Mokros

Catalyst: A Social Justice Forum

In a prior study psychopathic individuals showed a diminished level of cooperativeness but realized higher individual rewards in a prisoner’s dilemma game, compared with community controls. The present study replicated this finding with professional bank traders, who exhibited less cooperative behavior than both of the aforermentioned groups (community controls and psychopathic patients). While the bank traders did not obtain a higher gain than the psychopathic individuals at an absolute level, they maximized the discrepancy between their own profit and the yield of their anonymous computerized gaming partner. The bank traders were more prone than psychopathic patients to rely on strategies …