Medicine and Health Sciences Commons^™

Faculty Mentor Profile, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.

Differentiating Lymphovascular Invasion From Retraction Artifact On Histological Specimen Of Breast Carcinoma And Their Implications On Prognosis., Nicholas George Zaorsky, Ninad Patil, Gary Mitchel Freedman, Madalina Tuluc

Department of Radiation Oncology Faculty Papers

On a pathological specimen of breast cancer cells, retraction artifact during histological processing mimics true lymphovascular invasion (LVI). The accurate determination of the presence or absence of LVI is a factor in determining risk of having a positive sentinel node, or having additional positive axillary nodes after a positive sentinel node biopsy in women with early-stage breast cancer. The determination of nodal risk influences the decision of the treating physicians as to whether a sentinel node biopsy or completion axillary dissection is necessary. On slide preparation, ideal factors favoring true LVI include: a definite endothelial lining, with endothelial nuclei that …

Privacy And Security Issues In Iot Healthcare Applications For The Disabled Users A Survey, Wassnaa Al-Mawee

Masters Theses

Aging of the population resulted in new challenges for the society and healthcare systems. Ambient Assisted Living (AAL) that depends on Internet of Things (IoT) provides assistance to the disabled people and supports their vital daily life activities. Affordability of and accessibility to AAL and the usage of IoT starts revolutionizing healthcare services. This Thesis is a survey of the privacy and security issues in IoT healthcare applications for the disabled users. Introduction includes definitions of privacy and security terms, and discusses their relationship. Then, it presents an overview of the IoT, including its architecture and components. Next, the Thesis …

Influence Of Body Mass Index And Antibiotic Dose On The Risk Of Surgical Site Infections In Pediatric Clean Orthopedic Surgery., Jeffrey J Cies, Shannon Chan, Jobayer Hossain, B Randall Brenn, M Cecilia Di Pentima

Department of Anesthesiology Faculty Papers

OBJECTIVE: To evaluate body mass index (BMI) and antimicrobial dose as risk factors for surgical site infections in pediatric patients.

PATIENTS AND METHODS: Children between 2 and 19 years of age undergoing clean orthopedic procedures and receiving at least one dose of perioperative antibiotics (cefazolin, vancomycin, or clindamycin) were studied. The retrospective case-controlled study was conducted at the Alfred I. duPont Hospital for Children, a 180-bed tertiary-care academic pediatric hospital in Wilmington, DE. Data were collected from January 1, 2002, to December 31, 2005.

RESULTS: Underweight children had a higher risk for SSIs than overweight and normal-weight children. American Society …

Physical Demands Of Soccer: Lessons From Team Usa And Ghana Matches In The 2010 Fifa World Cup, Wycliffe W. Njororai Simiyu

Health & Kinesiology Faculty Publications and Presentations

Purpose: Distance covered and the intensity patterns of player movements using selected matches involving the national teams of United States of America and Ghana in the World Cup Soccer Tournament held in South Africa from June 11th to July 11th 2010. Methodology: A total of eight matches played by nine teams were used in the study. Team USA played against England, Slovenia, Algeria and Ghana. The national team of Ghana played against Germany, Australia, Serbia, USA and Uruguay. The eight matches comprised 12.5% of all matches played while the nine countries comprised 32% of all the tournament participating countries. Results: …

Vertical Violence And The Student Nurse: Is This Toxic For Professional Identity Development?, Sherri Williams Cantey

Dissertations

This narrative inquiry centers on student nurses’ stories of vertical violence perpetuated by clinical registered nursing staff and the meaning that students associate with this phenomenon. Student nurses are the very young and potentially impressionable members of our profession; therefore, a concern of this study was if vertical violence affects professional identity development for the student nurse. Additionally through stories revealed by these participants, this study attempted to explore whether perceptions of violence are believed to be a rite of passage into the profession. Students are the future of our profession, and it is important that this phenomenon be understood …

The Real Toy Story: The San Francisco Board Of Supervisors Healthy Food Incentives Ordinance, Cortney Price

Journal of Food Law & Policy

Obesity among children in the United States has tripled over the last thirty years. Incidentally, the world's largest fast food restaurant, McDonald's, first introduced its children's Happy Meal thirty-two years ago. Shortly thereafter, the first Disney inspired toy found its way into Happy Meals and the hearts of the "billions and billions served." Although the iconic Happy Meal and accompanying toy have become "a staple of Americana akin to baseball and apple pie," the continued existence of the practice is being threatened in light of the powerful influence toys have on children's food choices, thus contributing to the current obesity …

Skin Cell Proliferation Stimulated By Microneedles, Horst Liebl, Luther C. Kloth

Physical Therapy Faculty Research and Publications

A classical wound may be defined as a disruption of tissue integrity. Wounds, caused by trauma from accidents or surgery, that close via secondary intention rely on the biological phases of healing, i.e., hemostasis, inflammation, proliferation, and remodeling (HIPR). Depending on the wound type and severity, the inflammation phase begins immediately after injury and may last for an average of 7–14 days. Concurrent with the inflammation phase or slightly delayed, cell proliferation is stimulated followed by the activation of the remodeling (maturation) phase. The latter phase can last as long as 1 year or more, and the final healed state …

Matrix Metalloproteinase Levels Identify Heart Failure Patients With Higher Burden Of Atrial Fibrillation, Toshimasa Okabe, Md, Avinash Chandra, Shaw R. Natan, Suzanne Adams, Jocelyn A. Sendecki, Melissa M. Mccarey, Reginald Ho, Md, Behzad B. Pavri, Md, Arnold J. Greenspon, Md, Daniel Frisch, Md

Department of Medicine Faculty Papers

Presented at ACC Mid-Atlantic conference in Washington DC.

INTRODUCTION/HYPOTHESIS

•Adverse cardiac remodeling and fibrosis provide an arrhythmic substrate for atrial fibrillation (AF), but the role of matrix metalloproteinases (MMPs) as a biomarker is not well understood. MMPs are zinc-dependent endopeptidases known to degrade substrates such as elastin, gelatin and collagen.

•In excised human atrial tissue, MMP 2 and 9 levels rise as the AF burden increases from sinus rhythm (“No AF”) to non-permanent AF (“Non-Prm AF”) to permanent AF (“PrmAF”). Higher plasma levels of MMPs are also associated with recurrent AF after cardioversion.

•This study sought to elucidate 1) the …

Survey Of Knowledge, Attitude And Practice Of Epilepsy Among 221 School Teachers In Karachi, Syed Wasim Akhtar, Zarin Mogal, Shaukat Ali, Munawar Ali, Abdul Latif Sonija, Husainuddin Afridi, Hasan Aziz

Pakistan Journal of Neurological Sciences (PJNS)

No abstract provided.

The Morbidity & Mortality Of Prevalent Heart Failure, Jennifer Kwon

Loma Linda University Electronic Theses, Dissertations & Projects

The first study population included 292 unselected consecutive patients from the LLUMC heart failure clinic who were enrolled in the study from January to July 2006 and were followed up through the end of December 2010. The treatment policy at the clinic was to uptitrate dosages of beta-adrenergic blockade (β-blockers), angiotensin-converting-enzyme inhibitors (ACEi) and angiotensin II receptor blockers (ARB) to the most tolerable levels in order to reach target dosages, as recommended by the Heart Failure Society of America (HFSA). Patients were classified into systolic heart failure (ejection fraction (EF) < 40%) or diastolic heart failure (EF≥40%). All dosages of β-blockers, ACEi and ARB were extracted through chart reviews and were used as the main predictors of the patients' survival. Results from analyses showed that reaching target dosages of β-blockers and ACEi/ARB may increase survival when compared to not reaching target among the systolic HF population (HR_{β_biockers}= 0.64, 95% CI 0.26-1.56 and HR_ACEi/ARB=0.50, …

The Rna Binding Protein Ksrp Destabilizes Gap-43 Mrna To Limit Axonal Elongation In Cultured Hippocampal Neurons, Clark W. Bird

Biomedical Sciences ETDs

The KH-type splicing regulatory protein (KSRP) promotes the decay of AU-rich element (ARE) containing mRNAs. Although KSRP is expressed in the developing and mature nervous system, very little is known about its role in regulating gene expression in the brain. In this study, we utilized in vitro binding and decay studies to examine whether KSRP regulates the stability of the GAP-43 transcript, an ARE-containing neuronal mRNA whose protein product plays a role in axonal growth and synaptic plasticity. We found KSRP destabilizes GAP-43 mRNA by binding to the GAP-43 ARE, a process that depends on the presence of the fourth …

Cannabinoid 2 Receptor (Cb2r) Agonists Modulate Neuropathic Pain And Cytokine Expression, Jenny L. Wilkerson

Biomedical Sciences ETDs

The focus of the work in this dissertation is to elucidate the efficacy of cannabinoid 2 receptor agonists, specifically targeting the spinal cord, for the treatment of chronic neuropathic pain. Chemical structures for all cannabinoid compounds utilized are displayed (Supplemental Figure A-1). As an orientation for the reader, the organization of this dissertation consists of five components: chapters 1 through 5. In the first chapter, a background is developed to acquaint one with the topics of chronic pain, and the use of cannabinergic compounds for chronic pain relief. This chapter is in the form of a review, and specifically addresses …

Characterization Of The Count Rate Performance And Evaluation Of The Effects Of High Count Rates On Modern Gamma Cameras, Michael S. Silosky

Dissertations and Theses (Open Access)

CHARACTERIZATION OF THE COUNT RATE PERFORMANCE AND EVALUATION OF THE EFFECTS OF HIGH COUNT RATES ON MODERN GAMMA CAMERAS

Michael Stephen Silosky, B.S.

Supervisory Professor: S. Cheenu Kappadath, Ph.D.

Evaluation of count rate performance (CRP) is an integral component of gamma camera quality assurance and measurement of system dead time (τ) is important for quantitative SPECT. The CRP of three modern gamma cameras was characterized using established methods (Decay and Dual Source) under a variety of experimental conditions. For the Decay method, input count rate was plotted against observed count rate and fit to the paralyzable detector model (PDM) to …

Functional Analysis Of Drosophila Integrator Complex In Snrna 3' End Processing, Jiandong Chen

Dissertations and Theses (Open Access)

Uridine-rich small nuclear RNAs (U snRNAs) play essential roles in eukaryotic gene expression by facilitating the removal of introns from mRNA precursors and the processing of the replication-dependent histone pre-mRNAs. Formation of the 3’ end of these snRNAs is carried out by a poorly characterized, twelve-membered protein complex named Integrator Complex.

In the effort to understand Integrator Complex function in the formation of the snRNA 3’ end, we performed a functional RNAi screen in Drosophila S2 cells to identify protein factors required for snRNA 3’ end formation. This screen was conducted by using a fluorescence-based reporter that elicits GFP expression …

A Comparison Of Testosterone With Prostate Specific Antigen And Prostatic Acid Phosphatase For The Serodiagnosis Of Prostate Cancer In Adult Males, Annie Chu

Honors Theses

Prostate cancer is the second most common cause of death from cancer in men. The American Cancer Society has estimated that there were 240,890 newly diagnosed cases in 2011 and 33,720 deaths from prostate cancer. Diagnosis of this disease has traditionally been done by measuring prostate specific antigen (PSA) levels through sero-chemical testing. The purpose of this study is to compare serum testosterone levels to PSA levels and Prostatic Acid Phosphatase (PAP) levels in the search for new and more accurate technology. This study shows that testosterone was not efficient in correctly diagnosing those with prostate cancer. It had a …

Successful Management Of Severe Liver Failure On Venoarterial Extracorporeal Membrane Oxygenation Using Molecular Adsorbent Recirculating Systeme., Shigeki Tabata, Nicholas Cavarocchi, Hitoshi Hirose

Department of Surgery Faculty Papers

A 49-year-old female with Adriamycin induced cardiomyopathy presented with decompensated biventricular congestive heart failure. Despite multiple Inotropes, the patient’s hemodynamics deteriorated and she underwent veno-arterial extracorporeal membrane oxygenation (VA-ECMO) placement as a bridge to decision. Pre-ECMO workup showed liver dysfunction with elevated total bilirubin of 5.9 mg/dl, normal liver enzymes and liver ultrasound image. Tentative diagnosis of “end-stage liver failure” was made without a biopsy.

Shortly after initiation of ECMO, the patient developed massive hemoptysis which was successfully managed with continuation of ECMO and ventilator management. [i] The patient’s total bilirubin continued to increase to peak of 56 mg/dl on …

Immersion Research Education: Students As Catalysts For International Collaboration Research, Kathryn H. Anderson, Marie-Luise Friedemann, Andreas Buescher, Julita Sansoni, Donna R. Hodnicki

Nursing: Faculty Publications

Background:  This paper describes an international nursing and health research immersion program. Minority students from the USA work with an international faculty mentor in teams conducting collaborative research. The Minority Health International Research Training (MHIRT) program students become catalysts in the conduct of cross-cultural research.

Aim:  To narrow the healthcare gap for disadvantaged families in the USA and partner countries.

Methods:  Faculty from the USA, Germany, Italy, Colombia, England, Austria and Thailand formed an international research and education team to explore and compare family health issues, disparities in chronic illness care, social inequities and healthcare solutions. USA …

Histologic Findings In Biopsies/Resection Specimens From The Small Intestine With Special Emphasis On Celiac Disease: Experience From A Developing Country In South Asia, Huma Arshad, Zubair Ahmad

Department of Pathology and Laboratory Medicine

Biopsies from the small intestine especially the duodenum are now being performed much more frequently than in the past. The most frequent reason for performing duodenal biopsies is to evaluate for malabsorption. In the last few years, increased awareness has resulted in more biopsies sent for evaluation of malabsorption, especially celiac disease (CD). In the duodenum, features of malabsorption (increased intraepithelial lymphocytes, villous shortening, and atrophy) were the most common histologic finding seen in 63.4% of cases. Serum tTG levels were available for correlation in 52.8% of cases. In patients with confirmed CD, 53.4% were MARSH IIIb, and 29.5% were …

Development And Validation Of Sunlight Exposure Measurement Questionnaire (Sem-Q) For Use In Adult Population Residing In Pakistan, Quratulain Humayun, Romaina Iqbal, Iqbal Azam, Aysha Habib Khan, Amna Rehana Siddiqui, Naila Baig Ansari

Department of Pathology and Laboratory Medicine

Background: Vitamin D deficiency has been identified as a major public health problem worldwide. Sunlight is the main source of vitamin D and its measurement using dosimeters is expensive and difficult for use in population-based studies. Hence, the aim of this study was to develop and validate questionnaires to assess sunlight exposure in healthy individuals residing in Karachi, Pakistan.

Methods: Two questionnaires with seven important items for sunlight exposure assessment were developed. Fifty four healthy adults were enrolled based on their reported sunlight exposure (high = 17, moderate = 18, low = 19) from Aga Khan University, Karachi. Over four …

Correlation Of Respiratory Symptoms And Spirometric Lung Patterns In A Rural Community Setting, Sindh, Pakistan: A Cross Sectional Survey, Imran Naeem Abbasi, Adeel Ahsan, Asaad Ahmed Nafees

Community Health Sciences

Background: Symptom-based questionnaires can be a cost effective tool enabling identification and diagnosis of patients with respiratory illnesses in resource limited setting. This study aimed to determine the correlation of respiratory symptoms and spirometric lung patterns and validity of ATS respiratory questionnaire in a rural community setting.
Methods: This cross sectional survey was conducted between January - March 2009 on a sample of 200 adults selected from two villages of district Khairpur, Sindh, Pakistan. A modified version of the American thoracic society division of lung disease questionnaire was used to record the presence of respiratory symptoms. Predicted lung volumes i.e. …

A Comprehensive Study Of Ayurveda, Traditional Chinese Medicine, And Comparison, Per Maximilian Gasseholm

Social Sciences

Today complimentary medicine is being increasingly sought out. Ayurveda and TCM, are among the oldest systems of medicine and have been developed for over thousands of years in India and China respectively. This paper details the philosophies, medical theories, anatomy, diagnosis, and treatments of both of these systems, including a comparison. Both of these modalities of healing operate with a microcosm – macrocosm paradigm. This makes them fundamentally similar, and compatible with each other. Ayurveda uses Tridoshic theory to apply treatments ranging from diet, massage, meditation, yoga among other therapies to bring Vata, Pitta, and Kapha into balance. TCM is …

A Clinical Approach To Myopathy, Sara Khan

Pakistan Journal of Neurological Sciences (PJNS)

No abstract provided.

The Effect Of Weight Loss On Changes In Health-Related Quality Of Life Among Overweight And Obese Women With Urinary Incontinence, Angela Marinilli Pinto, Leslee L. Subak, Sanae Nakagawa, Eric Vittinghoff, Rena R. Wing, John W. Kusek, William H. Herman, Delia Smith West, Miriam Kuppermann

Publications and Research

OBJECTIVE: To estimate the effect of change in weight and change in urinary incontinence (UI) frequency on changes in preference-based measures of health-related quality of life (HRQL) among overweight and obese women with UI participating in a weight loss trial.

METHODS: We conducted a longitudinal cohort analysis of 338 overweight and obese women with UI enrolled in a randomized clinical trial comparing a behavioral weight loss intervention to an educational control condition. At baseline, 6, and 18 months, health utilities were estimated using the Health Utilities Index Mark 3 (HUI3), a transformation of the SF-36 to the preference-based SF-6D, and …

Structure-Function Analysis Of A Protein Encoded By The Bhv-1 Latency Related Gene, Devis Sinani

School of Veterinary and Biomedical Sciences: Dissertations, Theses, and Student Research

Bovine herpes virus 1 (BHV-1) is a significant viral pathogen in cattle that induces a myriad of clinical symptoms. These symptoms include: conjunctivitis, upper respiratory tract infections, genital disorders, and abortions. BHV-1 infection can also lead to transient immune-suppression, which predisposes cattle to secondary bacterial infection leading to life-threatening pneumonia referred to as bovine respiratory disease (BRD). Following acute infection, BHV-1 establishes latency in sensory neurons within trigeminal ganglia. Reactivation of the virus can occur periodically, resulting in virus transmission. The latency-related (LR) RNA is the only abundantly expressed transcript in latently infected sensory neurons and it encodes several proteins, …

Building A Strategic Framework For Comparative Effectiveness Research In Complementary And Integrative Medicine, Claudia M. Witt, Margaret Chesney, Richard Gliklich, Lawrence Green, George Lewith, Bryan Luce, Anne Mccaffrey, Shelly Rafferty Withers, Harold C. Sox, Sean Tunis, Brian M. Berman

Dartmouth Scholarship

The increasing burden of chronic diseases presents not only challenges to the knowledge and expertise of the professional medical community, but also highlights the need to improve the quality and relevance of clinical research in this domain. Many patients now turn to complementary and integrative medicine (CIM) to treat their chronic illnesses; however, there is very little evidence to guide their decision-making in usual care. The following research recommendations were derived from a CIM Stakeholder Symposium on Comparative Effectiveness Research (CER): (1) CER studies should be made a priority in this field; (2) stakeholders should be engaged at every stage …

Biochemical Characterization Of Binding Partners Of Two Hsp70 Co-Chaperones In Saccharomyces Cerevisiae, Jacob Verghese

Dissertations and Theses (Open Access)

Cells are exposed to a variety of environmental and physiological changes including temperature, pH and nutrient availability. These changes cause stress to cells, which results in protein misfolding and altered cellular protein homeostasis. How proteins fold into their three-dimensional functional structure is a fundamental biological process with important relevance to human health. Misfolded and aggregated proteins are linked to multiple neurodegenerative diseases, cardiovascular disease and cystic fibrosis. To combat proteotoxic stress, cells deploy an array of molecular chaperones that assist in the repair or removal of misfolded proteins.

Hsp70, an evolutionarily conserved molecular chaperone, promotes protein folding and helps maintain …

A Study On The Function Of 14-3-3sigma In Regulating Cancer Energy Metabolism, Liem M. Phan, Liem M. Phan

Dissertations and Theses (Open Access)

Metabolic reprogramming has been shown to be a major cancer hallmark providing tumor cells with significant advantages for survival, proliferation, growth, metastasis and resistance against anti-cancer therapies. Glycolysis, glutaminolysis and mitochondrial biogenesis are among the most essential cancer metabolic alterations because these pathways provide cancer cells with not only energy but also crucial metabolites to support large-scale biosynthesis, rapid proliferation and tumorigenesis. In this study, we find that 14-3-3σ suppresses all these three metabolic processes by promoting the degradation of their main driver, c-Myc. In fact, 14-3-3s significantly enhances c-Myc poly-ubiquitination and subsequent degradation, reduces c-Myc transcriptional activity, and down-regulates …

Aging And Religious Participation In Late Life, Kuan-Yuan Wang

College of Education and Human Sciences: Dissertations, Theses, and Student Research

Objective: The aim of the study is to evaluate the relationship between two dimensions of religiosity, religious service attendance and religious beliefs, and the process of aging, controlling for the effects of covariates known to affect religious development among older adults.

Methods: Secondary analysis of longitudinal data from the Florida Retirement Study was used to assess the trajectories of religious development over time as modeled with two growth processes: religious service attendance and religious beliefs. We analyzed data from six interview waves (Waves 1 and 5 - 9) with 1000 older adults age 72 or over. Covariates included demographic factors …

Attitudes Of College Students In Relationship To Weight And Physical Activity, Emily N. Estes

Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research

Abstract

BACKGROUND: There is a limited amount of knowledge of the impact current and goal weights of college students have on their attitudes surrounding weight and physical activity.

OBJECTIVE: To examine weight/body image and physical activity attitudes of students and whether those attitudes correlate current and goal weights of students.

SETTING: The questionnaires utilized were completed between the years 2006-2011 at the University of Nebraska—Lincoln.

PARTICIPANTS: Male and female students from the University of Nebraska—Lincoln.

RESULTS: The mean BMI of all participants (n=2255) was 23.8 ± 4.1; for females (n=1403) 23.0 ± 4.0; and for males (n=852) 24.9 ± …