Medicine and Health Sciences Commons^™

The Association Between Marital Transitions, Body Mass Index, And Weight: A Review Of The Literature, Lauren Dinour, May May Leung, Gina Tripicchio, Sahar Khan, Ming-Chin Yeh

Publications and Research

Objective: To examine the association between different marital transitions and changes in body mass index (BMI) and body weight.

Methods: A systematic literature search was conducted for peer-reviewed articles published between January 1990 and December 2011. Longitudinal studies were included if they compared dependent variables, such as BMI or weight, before and after a change in marital status.

Results: Twenty articles were included: 4 articles described only transitions into marriage and/or cohabitation, 2 articles described only transitions out of marriage and/or cohabitation, and 14 articles described both. Overall, transitions into marriage were associated with weight gain, whereas transitions out of …

Patient Safety Competencies In Rural Asn Students: An Evidence-Based Curricular Innovation, Janeen Berndt

Evidence-Based Practice Project Reports

Hospital clinical experiences are important events in prelicensure nursing education. Benefits include the opportunity for students to experience actual nursing responsibilities, immersion into environment, and professional socialization. However, challenges in finding appropriate clinical experiences include competition over clinical sites, decreasing patient acuity, and high student-faculty ratios. Rural schools of nursing have these challenges and those inherent in rural environments such as limited health care access, restricted critical access hospitals, and limited resources. The purpose of this evidence-based practice project was to plan, implement, and evaluate the use of a series of patient care simulations as an educational intervention to improve …

Linguistic Devices, Emotionality, And Memorability Of Computer Mediated Communication, Angela M. Mion

Undergraduate Honors Thesis Collection

I examined whether college students use shortcuts, pragmatics, and errors in text messages differently depending on their gender and the emotionality of the message. Results indicate that the prevalence of particular shortcuts differed across happy, sad, and angry messages, but gender did not influence use of linguistic devices. In a second study, I examined the emotionality and memorability of text messages versus voicemails. Results indicate that texts may be remembered better than voicemails, and happy, sad, and angry messages may be remembered differently by men and women.

Safety Of Saccharomyces Boulardii (Florastor) In Solid Organ Transplant Patients, Nicole Marie Dores

Undergraduate Honors Thesis Collection

Probiotics have been promoted for use in many gastrointestinal ailments. Most studies find probiotics safe for human use, reporting no severe adverse effects. However, probiotics are live microorganisms and thus have the potential to cause infection. Transplant recipients are considered at high risk for infectious complications from probiotics due to the immunosuppressive medications used to prevent organ rejection. Nonetheless, clinicians are currently utilizing probiotics in the transplant population, due to their benefit in gastrointestinal disorders, particularly recurrent Clostridium difficile. Limited knowledge and paucity of prospective trials in this patient population demands the need for completion of studies to identify the …

Expressed Emotion And Attitudes Toward Body Image And Food, Toni Marie Maraldo

Undergraduate Honors Thesis Collection

In numerous studies over the years, body image and dysfunctional attitudes toward food have shown to be related to the genesis of eating disorders. Recent research has particularly focused on the influence that families have on both the development of eating disorders as well as their impact on their child's body image and eating attitudes. In general, higher levels of expressed emotion are often found in families with children who have either anorexia nervosa or bulimia nervosa. However, there is a lack of research on sub-clinical populations. Therefore, the purpose of this study is to analyze the influence that expressed …

Over-The-Counter Non-Steroidal Anti-Anflammatory Drugs In Adolescent Athletes, Anna Christine Parada

Undergraduate Honors Thesis Collection

Non-steroidal anti-inflammatory drugs (NSAIDs) are common medications used by the general population due their anti-inflammatory and analgesic properties. These are especially popular in athletes since they are not prohibited in many rules of athletic competition. Over-the-counter (OTC) NSAIDs comprise several drugs that may be purchased without a prescription. These are often over-utilized by the general population due to their accessibility and relatively low cost. The unsuspecting victims are the children, especially adolescent athletes, who deem OTC NSAIDs safe without realizing the potential adverse effects of inappropriate consumption of these medications. This article reviews the approved indications and side effects of …

Pharmacy And Empathy: Evaluating The Impact Of A Pharmacy Student's Project In A Service-Learning Course, Carly D'Agostino

Undergraduate Honors Thesis Collection

Background: Empathy is taking on a larger role in the pharmaceutical field as pharmacists place emphasis on patient centered care. Service-learning courses can expose pharmacy students to future patients, allowing them to interact and develop empathy. While this study suggests service-leaming can foster empathy, further research is needed to assess the specific outcome of empathy as a result of incorporating a project in a service-learning course for pre-pharmacy students.

Objective: To evaluate the effect on a pharmacy student's empathy after completing a one-on-one patient interview project during a service-learning experience. A secondary objective is to assess tile validity of a …

Delivering Quality Care: The Roles And Future Of Midwives In Southern California, Abigail Jones

Scripps Senior Theses

The United States is ranked 27^th in the world for maternal mortality, yet spends twice as much on maternity care services as countries with better maternal health indicators. Stuck in a technocratic and physician-dominated maternity care system, the U.S. depends on expensive technologies to control birth out of fear of pain and litigation, costing Americans billions of dollars and depriving women of the opportunity to have a transformative birth experience. Through an analysis of the medicalization of birth and the current biomedical model in birth, in conjunction with open-ended interviews with 5 hospital midwives and 3 homebirth midwives, the …

P-Glycoprotein Functional Studies To Evaluate The Effect Of Cyclosporine Emulsion Formulations On Reversal Of Resistance In The Multidrug Resistant Cancer Cell Line Mes-Sa-Dx5, Katherine E. Cich

Undergraduate Honors Thesis Collection

Background: The overexpression of an efflux protein, p-glycoprotein (P-gp), is a leading cause of multi drug resistance (MDR). This research project is based on designing emulsions containing optimal doses of cyclosporine (CyA) and Pluronic® P-85 (P85), two agents found to be effective in inhibiting P-gp. Study

Objective: To investigate whether CyA exposure affects the quantity or functionality of P-gp in vitro.

Methods: To study the functionality of P-gp, MDR cells were incubated with CyA solutions containing the P-gp substrate and fluorescent dye Rhodamine 123 (RI23). P-gp inhibition was measured by fluorescence spectrophotometry, which indicates the accumulation of R123 inside the …

The Association Between Emotional Intelligence And Sexual Risk Behavior Among Undergraduate College Students In The Greater Los Angeles, Deborah E. Ortiz

Scripps Senior Theses

Sexual risk behaviors pose a major public health problem. However, sufficient research has not been done on the relationship between health risk behaviors and emotional intelligence. The purpose of this study was to examine the relationship between emotional intelligence, and sexual, smoking, and alcohol behavior among young adults. As well as explore the relationship between health risk behaviors. Emotional intelligence and sexual, alcohol, and smoking behavior of undergraduate college students from the greater Los Angeles area was assessed through an anonymous online questionnaire (n=80). There was no significant difference found in emotional intelligence between college students engaging in risk behaviors …

Reduction Of Na/K-Atpase Potentiates Marinobufagenin-Induced Cardiac Dysfunction And Myocyte Apoptosis, Changxuan Liu, Yan Bai, Yiliang Chen, Yu Wang, Yoann Sottejeau, Lijun Liu, Xiaomei Li, Jerry B. Lingrel, Deepak Malhorta, Christopher Cooper, Joseph I. Shapiro M.D., Zi-Jian Xie, Jiang Tian

Biochemistry and Microbiology

Background: Na/K-ATPase decrease has been reported in patients with heart failure and is related to cardiac dysfunction.

Results: Reducing Na/K-ATPase activates caspase 9 and induces cardiac dilation when treated with marinobufagenin.

Conclusion: Reduction of Na/K-ATPase potentiates marinobufagenin-induced cardiac myocyte apoptosis.

Significance: Decreased Na/K-ATPase content together with increased cardiotonic steroids levels is a novel mechanism that may account for cardiac dysfunction.

Utility Of B-Raf Dna Mutation In Diagnosis And Treatment Of Cancer, Dave S B Hoon

Technology Transfer - Patents

The present invention discloses a method of detecting a wild-type or mutant B-RAF gene in a body fluid sample from a subject. Also disclosed are methods of using B-RAF as a biomarker for detecting cancer, predicting the outcome of cancer, and monitoring the treatment of cancer or the status of cancer. Furthermore, the invention discloses methods and compositions for detecting a mutant gene with a peptide nucleic acid clamp capable of hybridizing to a wild-type gene and a locked nucleic acid probe capable of hybridizing to a mutant of the gene.

The Effects Of Xanthigen Supplementation On Body Weight, Resting Energy Expenditure, And Body Composition In An Obese Population, Lisa Knecht

Honors Theses

Since obesity is a significant problem that is facing the American people, there has been great interest in trying to develop a successful health supplement to help counteract the effects of obesity. Xanthigen is a new supplement composed of brown seaweed extract and pomegranate seed oil and is theorized to increase resting energy expenditure and decrease BMI and body fat. This study involved a 16‐week supplementation protocol to examine the effects of Xanthigen supplementation on an obese population in the Mississippi area. Testing of resting energy expenditure, BMI, and body fat percentage took place every four weeks for 16 weeks. …

Signal Transducer And Activator Of Transcription-5 Mediates Neuronal Apoptosis Induced By Inhibition Of Rac Gtpase Activity., Trisha R Stankiewicz, F Alexandra Loucks, Emily K Schroeder, Marja T Nevalainen, Kenneth L Tyler, Klaus Aktories, Ron J Bouchard, Daniel A Linseman

Department of Cancer Biology Faculty Papers

In several neuronal cell types, the small GTPase Rac is essential for survival. We have shown previously that the Rho family GTPase inhibitor Clostridium difficile toxin B (ToxB) induces apoptosis in primary rat cerebellar granule neurons (CGNs) principally via inhibition of Rac GTPase function. In the present study, incubation with ToxB activated a proapoptotic Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway, and a pan-JAK inhibitor protected CGNs from Rac inhibition. STAT1 expression was induced by ToxB; however, CGNs from STAT1 knock-out mice succumbed to ToxB-induced apoptosis as readily as wild-type CGNs. STAT3 displayed enhanced tyrosine phosphorylation following …

Weak Central Coherence Theory Problem Solving In Adults With Asperger Syndrome, Marie Ferderer

Honors Theses

This study examined the effect of Weak Central Coherence on problem solving strategies in adults with Asperger Syndrome. A group of adults with Asperger Syndrome and a group of Neurotypical adults were assessed using a riddle game. This game required participants to solve a riddle based on a cryptic language clue. The types of problem solving strategies employed by each group were recorded and compared in statistical analyses.

Significant differences in problem solving strategy were obtained for the two groups. The neurotypical group evidenced a strategy in which they considered the meaning of the language clue while attempting to solve …

The Effects Of Xanthigentm Supplementation On Body Composition, Serum Markers Of The Metabolic Syndrome, And Hepaptic Enzyme Levels In An Obese Population, Emily Buras

Honors Theses

XanthigenTM [100 mg brown seaweed extract (0.8 % fucoxanthin) and 100 mg pomegranate seed oil (70 % punicic acid)] has been shown to significantly reduce body fat, liver fat, and improve serum markers of liver function in obese females. Twenty-nine participants were matched for age, gender, and body fat percentage and randomized into either a XanthigenTM group or a placebo group. For 16-weeks, participants were asked to consume a reduced calorie diet while supplementing their diet with their respective pills three times per day. Data were analyzed using multivariate ANOVA with repeated measures and presented as mean ± standard deviation. …

Knowledge And Attitudes Regarding The Human Papillomavirus And Hpv Vaccine Among College Students: A Gender Comparison Study, Kristen O'Flarity

Honors Theses

Objective: Both young men and women should obtain the human papillomavirus (HPV) vaccine in order to reach its intended public health benefits. Because men are behind in this vaccination campaign, this study compared knowledge and attitudes regarding HPV and the vaccine among college-aged men and women in order to improve vaccination strategies among this at-risk population.

Methods: A convenience sample of 95 university students, 40 men and 55 women, ages 18 to 26 (mean age of 20.2) completed self-administered pencil-and-paper questionnaires with approximately 40 questions that assessed the desired variables. Knowledge was measured through multiple choice and true/false questions. …

Testosterone Supplementation Effects On Low Bmd In Males Ages 19-62: A Six-Month Intervention, Kara Palmer

Honors Theses

The purpose of this study was to examine the effects of a six-month testosterone supplementation on bone mineral density (BMD) in males ages 19-62. Recruiting potential subject through a local clinic, five subjects were eligible for participation in the study. A pre-supplementation DEXA scan was used to measure BMD of the lumbar spine and hip. A post-supplementation DEXA was done after six months of supplementation; the same sites were scanned. Of the initial five subjects, three subjects completed the study. All subjects showed an increase in serum testosterone levels (∆= +537 ng/dL). After the supplementation subject one showed an increase …

Perceptions Of The Deaf Among Various University Social Groups, Ashley Thrash

Honors Theses

Due to lack of previous research in this area, research for this project will be conducted on various social groups on the Hattiesburg campus of the University of Southern Mississippi in order to determine the attitudes towards the deaf held by each social group. (For this project, a social group is defined as an organization whose members are college students on a university campus.) Research will be conducted through the use of a survey instrument designed to measure hearing people’s perception of deaf people, in terms of their intelligence, job skills, communication skills, academic skills, ability to deal with traffic, …

Barriers And Motivators For Influenza Vaccination Compliance Among Healthcare, Shelby Rogers

Honors Theses

The influenza vaccine is a topic of much debate and concern throughout the healthcare profession. This vaccination has been shown to drastically reduce the number of nosocomial infections of the flu among hospitalized patients. While many healthcare professionals are aware of the benefits of obtaining the influenza vaccination, many remain noncompliant to actually getting vaccinated. This research will use a form of evidence-based practice known as an integrative review of literature in order to determine the course of nursing action to implement regarding influenza vaccination that will best increase the rates of its compliance among health professionals. A number of …

Obesity Trends In Head Start Preschoolers, Anna Sanders

Honors Theses

The purpose of this natural comparative study is to see if changes in diet, education, and activity made in a South Mississippi Head Start (HS) preschool from Fall 2007 through Fall 2010 made any changes in the Body Mass Index (BMI) trends in two cohorts of low-income African American 3-year-olds. Cohort 1 BMI trends were measured in Fall 2006 and Spring 2007, before major HS changes in diet, education and activity were made (pre-treatment), and Cohort 2 was measured in Fall 2010 and Spring 2011, after major changes were made (post-treatment).

An Investigation On The Interaction Of Various Natural Products With The Amyloid-Β Peptide; Betulinic Acid Causes Rapid Amyloid-Β Fibril Formation At The Expense Of Soluble Oligomers, Matthew Planchard

Honors Theses

In this report we investigate the interaction of the natural compounds asiatic acid (AA), asiaticoside (AS), umbelliferone (UM), and betulinic acid (BA) with the amyloid-β (Aβ) peptide, the aggregation of which is implicated to be the major pathogenic event in Alzheimer's Disease (AD). Screening of compounds for ability to affect Aβ aggregation was performed via ThT fluorescence. Only BA showed consistent deviation from controls, causing virtually instantaneous formation of large amounts of fibrils in a concentration-dependent fashion. Turbidity assays ensured the aggregation monitored via ThT was not experimental aberration. Kinetics utilizing ThT and turbidity indicated that BA causes immediate exponential …

Teaching With Cultural Competence Requires Gender Sensitivity, Marna R. Greenberg Do, Mph, Facep

Department of Emergency Medicine

No abstract provided.

Instructions For Authors

Journal of Health Disparities Research and Practice

The Journal of Health Disparities Research and Practice publishes research to guide the development of evidence-based solutions, policy and programs in an effort to reduce and ultimately eliminate health disparities. Published quarterly, the journal is an on-line publication that explores the problems and challenges of health disparities among the diverse populations of the United States. The journal welcomes submissions of original papers from researchers, public health practitioners, and students researching and working on health disparities solutions. Research briefs and conference announcements are also welcome. We are sorry but we cannot post job announcements. Questions about the suitability of a topic …

Feasibility And Acceptability Of An English-As-A-Second Language Curriculum On Hepatitis B For Older Chinese American Immigrants, Gloria D. Coronado, Elizabeth Acorda, H. H. Do, Victoria M. Taylor

Journal of Health Disparities Research and Practice

Asian immigrants to the U.S. have an increased prevalence of hepatitis B virus (HBV) infection compared to native born individuals; an estimated 10 percent of Chinese immigrants are infected with HBV. Using qualitative data from focus groups, we developed an English-as-a-Second Language (ESL) curriculum that aimed to improve knowledge about key hepatitis B facts. The curriculum was pilot-tested among 56 students aged 50 and older from intermediate-level ESL classes at a community-based organization that serves Chinese immigrants. Post-curriculum data showed increases in knowledge that hepatitis B can cause liver cancer (73% at pre-test vs. 91% at post-test; p value = …

Racial And Ethnic Differences In Cardiovascular Disease Risk Factors In U.S. Older Women: Findings From Behavioral Risk Factor Surveillance Survey, 2003 & 2004, Anita K. Kurian, Kristine Lykens, Sejong Bae, Karan P. Singh

Journal of Health Disparities Research and Practice

The purpose of this study was to examine racial and ethnic variations in the modifiable CVD risk factors in older women (65 years and older). The study data was drawn from the merged 2003 and 2004 national Behavioral Risk Factor Surveillance Survey (BRFSS). Multinomial regression analyses for indicator outcome and multiple logistic regression analyses for binary outcomes were performed to determine the relationship between each of the six dependent variable and the independent variables. Compared to older white women, older black women had significantly higher odds of hypertension, diabetes and obesity. No significant association was found between Hispanics and hypertension. …

Predictors Of Depression For Low-Income African American Single Mothers, Jennifer Hatcher, Mary K. Rayens, Ann R. Peden, Lynne A. Hall

Journal of Health Disparities Research and Practice

Purpose: To test a model of predictors of depression in low-income single African American mothers. Design: Secondary analysis of existing data collected as part of a study of women at risk for clinical depression.

Methods: Cross sectional secondary data analysis of a study of low-income African American single mothers with children ages 2-6. Path analysis was used to test a model of the potential mediating role of negative thinking. It was hypothesized that negative thinking mediates the effects of chronic stressors, general health status, and self-esteem on depressive symptoms

Finding: Negative thinking mediated the relationships of chronic stressors and self-esteem …

Evaluating “Not In Mama's Kitchen” Second-Hand Smoke Campaign In Georgia, Jonathan B. Vangeest, Verna L. Welch

Journal of Health Disparities Research and Practice

In 2003-2005, the Association of Black Cardiologists, Inc. initiated the Not in Mama’s Kitchen (NIMK) second-hand smoke (SHS) prevention campaign in Georgia as part of their effort to reduce exposure to SHS in African American communities statewide. This initiative was evaluated using baseline data from pledge cards as well as data from a self-administered mail survey of 1,000 campaign participants. 14,770 Georgians participated in NIMK, signing pledges to make their homes and cars smoke free. Majorities of those surveyed followed through with their pledge, banning tobacco use in their homes (76.1%) and cars (80.2%). The program was cited by 65.4% …

Evaluation Of A Tobacco Educational Intervention For Pregnant Alaska Native Women, Christi A. Patten, Carrie Enoch, Caroline C. Renner, Karin Larsen, Paul A. Decker, Kari J. Anderson, Caroline Nevak, Ann Glasheen, Kenneth P. Offord, Anne Lanier

Journal of Health Disparities Research and Practice

Tobacco cessation interventions developed and evaluated for Alaska Native women do not exist. As part of routine clinical care provided at a prenatal visit, a brief tobacco educational intervention for Alaska Native pregnant women (N=100; mean ± SD age = 25.9±6.2 years; mean 6.3± 2.6 months gestation) was piloted at the Y-K Delta Regional Hospital in Bethel, Alaska. This retrospective study reports on the evaluation of this clinical program. The intervention was consistent with the clinical practice guidelines (i.e., 5 A’s – ask, advise, assess, assist, arrange), with an average duration of 20.2 ± 6.8 minutes. The self-reported tobacco abstinence …

African American Adults’ Experiences With The Health Care System: In Their Own Words, Keri A. Jupka, Nancy L. Weaver, Vetta L. Sanders-Thompson, Nicole M. Caito, Matthew W. Kreuter

Journal of Health Disparities Research and Practice

African Americans suffer a disproportionate burden of death and illness from a number of different chronic diseases. Inequalities in health care practices and poor patient and provider communication between African American patients and health care professionals contribute to these disparities. We describe findings from focus groups with 79 urban African Americans in which the participants discussed their interactions with the healthcare system as well as beliefs and opinions of the healthcare system and professionals. Analysis revealed five major themes: (1) historical and contextual foundations; (2) interpersonal experiences with physicians and other health care workers; (3) discrimination; (4) trust, opinions and …