Medicine and Health Sciences Commons^™

Carrs Surveillance Study: Design And Methods To Assess Burdens From Multiple Perspectives, Manisha Nair, Mohammed K. Ali, Vamadevan S. Ajay, Roopa Shivashankar, Viswanathan Mohan, Rajendra Pradeepa, Mohan Deepa, Hassan Mehmood Khan, Muhammad Masood Kadir, Zafar Fatmi, Srinath Srinath Reddy, Nikhil Tandon, Km Venkat Narayan, Dorairaj Prabhakaran

Community Health Sciences

Background: Cardio-metabolic diseases (CMDs) are a growing public health problem, but data on incidence, trends, and costs in developing countries is scarce. Comprehensive and standardised surveillance for non-communicable diseases was recommended at the United Nations High-level meeting in 2011.
Aims: To develop a model surveillance system for CMDs and risk factors that could be adopted for continued assessment of burdens from multiple perspectives in South-Asian countries.
Design: Hybrid model with two cross-sectional serial surveys three years apart to monitor trend, with a three-year prospective follow-up of the first cohort.Sites: Three urban settings (Chennai and New Delhi in India; Karachi in …

Idiopathic Pulmonary Haemosiderosis Presenting As Severe Iron Deficiency Anaemia--A Case From Pakistan, Noureen Afzal, Ammara Mushtaq, Arshalooz Rahman, Sonia Qureshi

Department of Paediatrics and Child Health

Idiopathic pulmonary haemosiderosis is an uncommon disorder, which is characterized by iron deficiency, recurrent haemoptysis and diffuse parenchymal infiltration on chest radiograph. We report an 8 year old child who had past history of multiple blood transfusions with diagnosis of iron deficiency anaemia and recurrent chest infection since the age of 21/2 year. At the age of 8 years, the child presented with fever and severe respiratory distress requiring intubation and ventilation. On Chest X-ray, bilateral white out was found and CT scan lung showed diffuse alveolar involvement. Lung biopsy confirmed haemosiderin-laden macrophages. Child was put on steroids and despite …

Unintentional Home Injury Risks Among The Elderly In Southern Nevada, Michelle Echauz Ching

UNLV Theses, Dissertations, Professional Papers, and Capstones

The elderly population (65 years of age and older) is one of the fastest growing populations in the US. A major public health concern involving the elderly population is unintentional injuries in the home. Since elderly adults typically spend the majority of their time in the home, minimizing unintentional home injury hazards is crucial for this population. The Nevada Healthy Homes Partnership (NHHP) program is a grant funded effort that helps to improve the quality and availability of safe and healthy homes in Nevada. Therefore, the purpose of this study is to determine the effectiveness of the NHHP program interventions …

Effect Of Gingival Margin Design On Retention Of Thermoformed Orthodontic Aligners, Daniel P. Cowley

UNLV Theses, Dissertations, Professional Papers, and Capstones

Purpose: The aim of this study was evaluate the effect of gingival margin design (scalloped vs. straight cut at gingival zenith vs. straight cut 2mm above gingival zenith) on the retention of thermoformed aligners. Retention of aligners is a critical requirement for efficient tooth movement.

Methods: Two thermoform aligner materials were used, Invisacryl A and Invisacryl C, in 0.040 mil (1mm) thickness. Six aligner designs were fabricated for each of the two aligner materials (12 total aligner designs). Aligner designs are scalloped, straight cut at gingival zenith (0mm), and straight cut 2mm above gingival zenith on a model with attachments. …

Utilization Of A Metabolic Syndrome Index In Evaluating The Life In Balance Lifestyle Intervention For Prevention Of Type 2 Diabetes Among Urban American Indians And Alaska Natives, Hongbin Jin

UNLV Theses, Dissertations, Professional Papers, and Capstones

Background: A myriad of diabetes prevention programs modeled on the Diabetes Prevention Program (DPP) are carried out worldwide to fight against the current diabetes pandemic. The percentage of weight reduction is a widely used indicator to evaluate diabetes prevention programs. However, weight change alone may not fully reflect the efficacy of lifestyle intervention. A metabolic syndrome index is a promising novel scale for evaluation of diabetes prevention programs because it is a systematic, comprehensive, and stable indicator that reflects the metabolic risk reduction for diabetes and its complications at multiple levels and dimensions.

Methods: A total of 22 overweight and …

Model Provisions For Building A Successful Lead Poisoning Prevention Program: A Case Study For The Western United States, Kathleen Lauckner

UNLV Theses, Dissertations, Professional Papers, and Capstones

It has been 236 years since Benjamin Franklin voiced his concerns about lead poisoning from the occupational exposures in his printing shop, yet, in 2012 childhood lead poisonings and adult occupational exposures are still serious public health issues in the United States. Lead poisoning is a 100% preventable affliction if the ingestion or inhalation of lead from environmental exposures can be avoided.

The quality of blood lead detection methods and brain function studies have improved dramatically over the last few decades and far more is now known about the adverse health effects from low level (microgram- µg) exposures to lead. …

Construct And Criterion Validity Of The Rey Auditory Verbal Learning Test-Spanish Version In Adults With Traumatic Brain Injury, Cristobal Neblina

UNLV Theses, Dissertations, Professional Papers, and Capstones

The Rey Auditory Verbal Learning Test (RAVLT) is among the most commonly used English-language neuropsychological tests of verbal learning and memory. Previous research supports the validity and clinical utility of adaptations of the RAVLT into many diverse languages. In the United States, Hispanics represent the largest and fastest-growing ethnic minority group. As the Hispanic populace continues to grow, so does the need for empirically validated Spanish-language neuropsychological measures. In 2002, a Spanish adaptation of the RAVLT was developed in Puerto Rico (Acevedo-Vargas, 2002). However, validation studies have not been undertaken with clinical samples, and little is known regarding its psychometric …

Frequency-Specificity And Pattern-Specificity Of The Buildup Of Auditory Stream Segregation, David Michael Weintraub

UNLV Theses, Dissertations, Professional Papers, and Capstones

During repeating sequences of low (A) and high (B) tones in an "...ABAB..." pattern, the likelihood of hearing two separate streams ("streaming") increases with more repetitions of the patterns, a phenomenon referred to as "buildup". Previous studies have shown that buildup is frequency specific (Anstis & Saida, 1985) and that its biasing effects decays over several seconds (Beauvois & Meddis, 1997). No study has examined whether the frequency specificity of buildup persists for such a long duration. To address these issues, Experiment 1 tested the decay of frequency-specific and non-frequency specific buildup. The results revealed that (1) frequency-specific buildup effects …

Laboratory And Field-Based Correlates Of Off-Road Cycling Performance, Joshua Adams

Boise State University Theses and Dissertations

The aims of this study were to identify physiologic characteristics among trained off-road cyclists and correlate them with a field-based time trial to determine predictors of live performance. Fourteen trained male off-road cyclists were recruited for this study, and measured for maximum aerobic capacity (VO_2max), peak aerobic power (W_peak), maximum anaerobic power (W_max), time trial performance (sec), and climbing ability (vertical feet per second – VFS). VO_2max and W_peak were measured during an incremental cycling test to exhaustion, W_max was measured during a 30-second Wingate test and time trial, and VFS …

Exogenous Alpha-Synuclein Induces Cell Death Related Proteins In C6 Oligodendrocyte-Like Cells Corresponding To Protein Expression Observed In Multiple System Atrophy, Derrick Samuel Hilton

Dissertations

Multiple System Atrophy (MSA) consists of three disorders; Autonomic Dysfunction, Cerebellar Ataxia, and Parkinsonism. In MSA, the protein Alpha-Synuclein (SNCA) appears in the central nervous system as misfolded protein aggregates primarily in oligodendrocytes. This dissertation reports the results from studies examining the effect of exogenous SNCA has on a cell model: C6 oligodendrocyte-like cells. Treated cells were evaluated using western blot and DNA microarray. In addition the expression of proteins was evaluated using immunocytochemistry in MSA patient tissue.

C6 cells were shown to take up SNCA when added to the media. SNCA also underwent a truncation when taken up by …

Were Equatorial Regions Less Affected By The 2009 Influenza Pandemic? The Brazilian Experience, Cynthia Schuck-Paim, Cecile Viboud, Lone Simonsen, Mark A. Miller, Fernanda E.A. Moura, Roberto M. Fernandes, Marcia L. Carvalho, Wladimir J. Alonso

Global Health Faculty Publications

Although it is in the Tropics where nearly half of the world population lives and infectious disease burden is highest, little is known about the impact of influenza pandemics in this area. We investigated the mortality impact of the 2009 influenza pandemic relative to mortality rates from various outcomes in pre-pandemic years throughout a wide range of latitudes encompassing the entire tropical, and part of the subtropical, zone of the Southern Hemisphere (+5°N to −35°S) by focusing on a country with relatively uniform health care, disease surveillance, immunization and mitigation policies: Brazil. To this end, we analyzed laboratory-confirmed deaths and …

An Exploratory Study Of Characteristics Associated With Postsecondary Educational Attainment In Students Who Are Deaf Or Hard Of Hearing, Amy Marie Hebert

Graduate Theses and Dissertations

It is well documented that attrition in the postsecondary settings for students who are deaf or hard of hearing is greatly due to their academic and communication skills, as well as pre-entry attributes. However there is little evidence that indicates why students who are deaf or hard of hearing are successful in the postsecondary setting. This study tested a hypothesis that demographic, family, psychological and educational variables have a relationship with postsecondary attainment. The variables included in the study were gender, race, math literacy, reading literacy, high school academic setting (public/residential), communication modality (sign language/oral speech), cochlear implant user, parental …

Assessment Of Satisfaction And Sustainability: The Idaho Healthy Eating, Active Living Network, Kristine E. Balisciano

Boise State University Theses and Dissertations

In recent years, there has been in increased focus, at local, state, and national levels, on addressing health disparities. The purpose of the Healthy Eating, Active Living (HEAL) Idaho Network is to create an environment that allows all its residents access to healthy food options and opportunities for physical activity. The HEAL Idaho Network initiative seeks to accomplish this goal through an expanding collaborative network of organizations, agencies, businesses, and individuals that are concerned about improving the health education and overall well-being of all Idahoans.

The purpose of this study was to assess HEAL member’s levels of satisfaction with the …

Identifying And Correcting Health Hazards In The Home: A Pilot Test Among Homes In Clark County, Nevada, Sabrina La Monica

UNLV Theses, Dissertations, Professional Papers, and Capstones

The Nevada Healthy Homes Partnership (NVHHP) is collaboration between University of Nevada - Las Vegas (UNLV), the Southern Nevada Health District (SNHD), and other public and private housing authorities and health agencies throughout Clark County, Nevada. The primary mission of the NVHHP is to improve the health of Nevada residents, particularly those in disadvantaged communities, by identifying and addressing conditions in the home environment. For this study, a program created by the NVHHP, entitled "Nevada Healthy Homes" (hereafter, Healthy Homes) was piloted. Home health and risk assessments were conducted in 52 homes, with one or more interventions being provided to …

Affect Identification And Interpersonal Skills: An In-Depth Evaluation Of Social Cognition In Schizophrenia, Griffin Pollock Sutton

UNLV Theses, Dissertations, Professional Papers, and Capstones

The presence of deficits in various sub-domains of social cognition has been investigated to a degree in individuals with schizophrenia. Some of the most commonly researched and documented deficits have included impairments in the identification of affect portrayed in faces. Research has indicated that the performance of individuals with schizophrenia on such tasks is generally impaired as compared to normal controls. However, some have questioned the generalizability of such findings to real-world situations, as day-to-day interactions generally necessitate a constant, fluid assessment of the thoughts and feelings of others and are rarely, if ever, limited to still images of others. …

Mini-Review: Decorin, A Guardian From The Matrix, Thomas Neill, Liliana Schaefer, Renato V. Iozzo

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Decorin, an archetypal member of the small leucine-rich proteoglycan gene family, has a broad binding repertoire that encompasses matrix structural components, such as collagens, and growth factors, particularly those that belong to the transforming growth factor-β ligand superfamily. Within the tumor microenvironment, stromal decorin has an inherent proclivity to directly bind and down-regulate several receptor tyrosine kinases, which are often overexpressed in cancer cells. The decorin interactome commands a powerful antitumorigenic signal by potently repressing and attenuating tumor cell proliferation, survival, migration, and angiogenesis. This collection of interacting molecules also regulates key downstream signaling processes indirectly via the sequestration of …

Yeast Surface Display Of Cd154, Iaryna Masniuk

Graduate Theses and Dissertations

The CD154 (CD40L) is a member of tumor necrosis factor (TNF) family that plays a crucial role in regulation of both cell-mediated and humoral immunity by activating antigen presenting cells (APCs). Previously, studies in the laboratory demonstrated that yeast surface display system allows the expression of biologically functional antigen, such as subunit HA, against influenza virus. Yeast surface display system seems to be an excellent system to be utilized to develop anti-influenza virus vaccine. Thus, it is of interest to study the adjuvant function of CD154 on the subunit HA vaccine against influenza virus. In this project, the CD154 encoding …

Hcv Behavioral Health Preparation Of The Racial/Ethnic Minority: Measurement Development Of A Hcv Treatment Readiness Tool In Spanish And English, Michele Vella, Joseph L. Yozviak Do, Facp, Judith Lash Rn

Department of Medicine

No abstract provided.

Obstructive Sleep Apnea And The Effects Of Co-Existing Factors On Pacu Stay Time, Shari F. Jones Phd, Crna

Dissertations

Significance/Background: Obstructive Sleep Apnea (OSA) is the most common disturbance during sleep affecting 30% of the population. The occurrence of moderate/severe OSA is 11.4% in men and 4.7% in women. OSA is caused by repetitive partial or complete obstruction of the upper airway with apnea episodes. OSA is prevalent in western society, yet is frequently undiagnosed due to lack of knowledge of the disorder. This population presents a challenge during the peri-operative period due to increased risk for several complications. Of particular interest to Nurse Anesthetists, are respiratory complications that result in delayed emergence from anesthesia, delayed post-operative recovery, increased …

Parenting And Feeding Behaviors Associated With School-Aged African American And White Children, Michele L. Polfuss, Marilyn Frenn

College of Nursing Faculty Research and Publications

Pediatric obesity is multifactorial and difficult to treat. Parenting and feeding behaviors have been shown to influence a child’s weight status. Most prior studies have focused on preschool-aged White children. Additional complicating factors include parents’ inability to accurately identify their child’s abnormal weight status. Parenting and feeding behaviors used by 176 African American and White parents of school-age children were examined. Assessment included (a) identifying what behaviors were reported when parent expressed concern with child’s weight and (b) the relationship of these behaviors on child’s body mass index percentile (BMI%), considering ethnicity, socioeconomic status (SES), and parent’s body mass index …

A Change In Pre-Participation Exam Guidelines For Student Athletes In The State Of Mississippi, Alisha Tenhet

MSN Research Projects

Despite the current requirements for pre-participation physical exams (PPE) in Mississippi, student athletes medically cleared during PPEs continue to experience sudden cardiac death from undiagnosed cardiac abnormalities. Research states that one in every 200,000 high school athletes experiences sudden cardiac death, the majority of which are attributed to structural heart problems. Although most high school athletes are required to complete a PPE, the concern is that physical exams alone are not enough to identify cardiac abnormalities. The purpose of this study is to determine if student athletes are appropriately screened for cardiac risks. The researchers compared current practices with existing …

Parenting And Feeding Behaviors Associated With School-Aged African American And White Children, Michele Polfuss, Marilyn Frenn

College of Nursing Faculty Research and Publications

Pediatric obesity is multifactorial and difficult to treat. Parenting and feeding behaviors have been shown to influence a child’s weight status. Most prior studies have focused on preschool-aged White children. Additional complicating factors include parents’ inability to accurately identify their child’s abnormal weight status. Parenting and feeding behaviors used by 176 African American and White parents of school-age children were examined. Assessment included (a) identifying what behaviors were reported when parent expressed concern with child’s weight and (b) the relationship of these behaviors on child’s body mass index percentile (BMI%), considering ethnicity, socioeconomic status (SES), and parent’s body mass index …

Improving Patient Flow In Emergency Department Through Dynamic Priority Queue, Kar Way Tan, Chao Wang, Hoong Chuin Lau

Research Collection School Of Computing and Information Systems

Most queuing problems are based on FIFO, LIFO, or static priority queues; very few address dynamic priority queues. In this paper, we present a case in a hospital’s emergency department (ED) where the queuing process can be modeled as a time-varying M/M/s queue with re-entrant patients. In order to improve patient flow in the department, we propose the use of a dynamic priority queue to dispatch patients to consultation with doctors. We test our proposed model using simulation and our experimental results show that a dynamic priority queue is effective in reducing the length of stay (LOS) of patients and …

Low Levels Of Β-Lactam Antibiotics Induce Extracellular Dna Release And Biofilm Formation In Staphylococcus Aureus., Jeffrey B. Kaplan, Era A. Izano, Prerna Gopal, Michael T. Karwacki, Sangho Kim, Jeffrey L. Bose, Kenneth W. Bayles, Alexander R. Horswill

Journal Articles: Pathology and Microbiology

UNLABELLED: Subminimal inhibitory concentrations of antibiotics have been shown to induce bacterial biofilm formation. Few studies have investigated antibiotic-induced biofilm formation in Staphylococcus aureus, an important human pathogen. Our goal was to measure S. aureus biofilm formation in the presence of low levels of β-lactam antibiotics. Fifteen phylogenetically diverse methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive S. aureus (MSSA) strains were employed. Methicillin, ampicillin, amoxicillin, and cloxacillin were added to cultures at concentrations ranging from 0× to 1× MIC. Biofilm formation was measured in 96-well microtiter plates using a crystal violet binding assay. Autoaggregation was measured using a visual test tube …

Contribution Of The Staphylococcus Aureus Atl Am And Gl Murein Hydrolase Activities In Cell Division, Autolysis, And Biofilm Formation., Jeffrey L. Bose, Mckenzie K. Lehman, Paul D. Fey, Kenneth W. Bayles

Journal Articles: Pathology and Microbiology

The most prominent murein hydrolase of Staphylococcus aureus, AtlA, is a bifunctional enzyme that undergoes proteolytic cleavage to yield two catalytically active proteins, an amidase (AM) and a glucosaminidase (GL). Although the bifunctional nature of AtlA has long been recognized, most studies have focused on the combined functions of this protein in cell wall metabolism and biofilm development. In this study, we generated mutant derivatives of the clinical S. aureus isolate, UAMS-1, in which one or both of the AM and GL domains of AtlA have been deleted. Examination of these strains revealed that each mutant exhibited growth rates comparable …

The Importance Of Amino Acid Composition In Natural Amps: An Evolutional, Structural, And Functional Perspective., Biswajit Mishra, Guangshun Wang

Journal Articles: Pathology and Microbiology

No abstract provided.

The Effects Of Yoga Therapy On The Quality Of Life For A Paraplegic Individual, Allison Renee Purdy

Dissertations and Theses

The purpose of this study was to document the effects that a regular yoga therapy practice has on the quality of life for a paraplegic individual. Due to the unique nature of spinal cord injury (SCI), this was a case study with one participant. For 5 weeks the subject practiced a standardized yoga routine three times a week with a yoga teacher, receiving private instruction. Interview questions were asked before and after the intervention to document the participant's quality of life. Each week, the subject completed a modified SF-36 questionnaire as well as Cohen's Perceived Stress Survey. Perceived pain and …

Classroom Misbehavior In The Eyes Of Students: A Qualitative Study, Rachel C. F. Sun, Daniel T. L. Shek

Pediatrics Faculty Publications

Using individual interviews, this study investigated perceptions of classroom misbehaviors among secondary school students in Hong Kong (N = 18). Nineteen categories of classroom misbehaviors were identified, with talking out of turn, disrespecting teacher, and doing something in private being most frequently mentioned. Findings revealed that students tended to perceive misbehaviors as those actions inappropriate in the classroom settings and even disrupting teachers' teaching and other students' learning. Among various misbehaviors, talking out of turn and disrespecting teacher were seen as the most disruptive and unacceptable. These misbehaviors were unacceptable because they disturbed teaching and learning, and violated the values …

In Vitro In Vivo Methods And Pharmacokinetic Models For Subcutaneously Administered Peptide Drug Products, Amit Somani

Theses and Dissertations

Over the last several years, injectable drugs have been a growing area for the treatment of various therapeutic conditions and they are projected to comprise an even larger proportion among the drugs that will be available in the years to come. The injectable drugs are administered by various routes such as intramuscular (IM), intravenous (IV), subcutaneous (SC) and others, however, the majority of these drugs are administered subcutaneously. Even though subcutaneous delivery has been utilized for a number of years, very little is known about the processes governing the absorption of macromolecules from the interstitial space; and the resulting impact …

Postlecture Evaluation Of A Positive Youth Development Subject For University Students In Hong Kong, Daniel T. L. Shek

Pediatrics Faculty Publications

The purpose of this study was to examine the postlecture evaluation by the students taking a course (Tomorrow's Leaders) that attempted to promote their leadership qualities and intrapersonal competencies at The Hong Kong Polytechnic University in Hong Kong. Except for the last lecture, students were invited to respond to a 12-item postlecture questionnaire after each lecture. Results showed that the students had positive perceptions of the subject, class, and teacher attributes, and they had positive global evaluation of the teacher and the subject. The postlecture evaluation questionnaire was found to possess good psychometric properties. Multiple regression analyses showed that subject, …