Medicine and Health Sciences Commons^™

Anti-Cancer Drug Screening Of Dual Tubulin And Hsp27 Inhibitors With 2d And 3d Lung Cancer Cell Assays, Janine Maria Naim, Rati Lama

Undergraduate Research Posters 2012

Cancer is the leading cause of death worldwide. The current treatment options available for lung cancer are limited and have drawbacks such as poor bioavailability, numerous side effects, poor efficacy and drug resistance. 3D model serve as a novel approach for drug screening purposes and the evaluation of compounds in the platform can help identify potent compounds for further in vivo xenograft studies.

Obtaining A Pure Protein Using An Elp-Tagged Tev Protease, Teisha L. Mullins

Undergraduate Research Posters 2012

We present here use of GLGVP for tagging and purifying a gadolinium binding protein domain.

Normalizing For Noise Removal From Electrocardiogram Signals, Dominique Diamond Brooks, Daniel J. Simon

Undergraduate Research Posters 2012

Electrocardiography (ECG) measures the electrical impulse of the heart over time using electrodes that attached to the body. Designing a computational program using a synthetic ECG to test Normalized Least Mean Square (NLMS) filter serves as a basis to remove noise from the signal.

Investigating Axonal Biology Using Microfluidic Devices, James Deyling, Brittany Kastan

Undergraduate Research Posters 2012

During nervous system development, various diffusing biomolecules play a critical role in neurite outgrowth and guidance, resulting in the formation of a complex circuitry. However, the precise mechanism by which these molecules are spatio-temporally delivered to the growing tip of the neurites is unclear. Overall, the results suggest to the utility of this device for studying neurobiology, tissue engineering and cell migration.

Understanding The Structure Of High Density Lipoprotein, Dmitriy Parshakov, Kayla T. Tran

Undergraduate Research Posters 2012

The high-density lipoprotein (HDL), the carrier of ‘good cholesterol’, transports cholesterol from periphery cells to liver for catabolism, a process termed reverse cholesterol transport. In this project we focused on obtaining and characterizing HDL particles.

Key Players In Reverse Cholesterol Transport: The Plasma Enzyme Lcat, Christopher J. Pechura

Undergraduate Research Posters 2012

Lecithin cholesterol acyltransferase (LCAT) is a plasma enzyme that remodels nascent high density lipoprotein (HDL) into a mature form called spherical HDL. The model will be used in the future to map the amino acid residues from LCAT and the protein component of nascent HDL (apoA1) involved in mutual interaction, and to identify LCAT residues interacting with the lipid phase of nascent HDL.

Biological Evaluation Of Cyclooxygenase-2 Inhibitor Nimesulide Derivatives As Anti-Agents, Amandeep Singh, Snigdha Chennamaneni

Undergraduate Research Posters 2012

Cyclooxygenase-2 (COX-2) inhibitor nimesulide inhibits the proliferation of various types of cancer cells mainly via COX-2 independent mechanisms, which makes it a good lead compound for anti-cancer drug development. A series of new nimesulide analogs were evaluated with cell proliferation assay based on a non-small lung cancer cell line H292. The results showed that several derivatives were very active to against H292 cell growth with IC50s of sub nano mole. These results suggest the possibility of using these nimesulide derivatives as chemo preventive agents.

Simulation And Control Of An Intelligent Prosthetic Knee With Biogeography-Based Optimization, George L. Thomas

Undergraduate Research Posters 2012

Traditional, passive leg prostheses for transfemoral amputees require the user to produce unnaturally large actuations in order to walk. The resulting motions can cause joint degeneration and arthritis. To avoid this, a semi-active prosthetic knee using hydraulics to store and release energy has been developed. In our work this summer, we have improved upon a previous simulation model for this leg, and we have developed preliminary valve control results in this simulation software with BBO.

Repair Of Nasal Septal Perforation With Porcine Small Intestinal Submucosa Xenograft, Jewel Greywoode, Md, James Hamilton, Md, Prashant S. Malhotra, Md, Abdel Saad, Md, Edmund A. Pribitkin, Md

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

Background:

Numerous techniques have been described for nasal septal perforation repair, with various degrees of success in achieving closure. Evidence supports the use of bilateral mucoperichondrial advancement flaps with interpositional grafting for greatest success. Many surgeons use autografts such as fascia, cartilage, bone, and pericranium, however, extracellular matrices have also become popular.

Objective:

We analyze factors determining the success of nasal septal perforations repaired using using an acellular, freeze-dried interpositional xenograft derived from Porcine Small Intestinal Submucosa (PSIS).

Methods:

Patients with septal perforation repaired by the senior author from 1998 to 2006 were examined in a retrospective chart review with …

The Study Of Hiv And Antenatal Care Integration In Pregnancy In Kenya: Design, Methods, And Baseline Results Of A Cluster-Randomized Controlled Trial, Janet M. Turan, Rachel L. Steinfeld, Maricianah Onono, Elizabeth A. Bukusi, Meghan Woods, Starley B. Shade, Sierra Washington, Reson Marima, Jeremy Penner, Marta L. Ackers, Dorothy Mbori-Ngacha, Craig R. Cohen

Pathology, East Africa

Background: Despite strong evidence for the effectiveness of anti-retroviral therapy for improving the health of women living with HIV and for the prevention of mother-to-child transmission (PMTCT), HIV persists as a major maternal and child health problem in sub-Saharan Africa. In most settings antenatal care (ANC) services and HIV treatment services are offered in separate clinics. Integrating these services may result in better uptake of services, reduction of the time to treatment initiation, better adherence, and reduction of stigma.

Methodology/Principal Findings: A prospective cluster randomized controlled trial design was used to evaluate the effects of integrating HIV treatment into ANC …

September 5, 2012, Communication Disorders & Sciences

Faculty Meeting Minutes & Agendas

Meeting minutes of the September 5, 2012 Faculty Committee meeting.

Hyperpolarized 3he And 129xe Mr Imaging In Healthy Volunteers And Patients With Chronic Obstructive Pulmonary Disease, Miranda Kirby, Sarah Svenningsen, Amir Owrangi, Andrew Wheatley, Adam Farag, Alexei Ouriadov, Giles E Santyr, Roya Etemad-Rezai, Harvey O Coxson, David G Mccormack, Grace Parraga

Medical Biophysics Publications

PURPOSE: To quantitatively compare hyperpolarized helium 3 (3He) and xenon 129 (129Xe) magnetic resonance (MR) images obtained within 5 minutes in healthy volunteers and patients with chronic obstructive pulmonary disease (COPD) and to evaluate the correlations between 3He and 129Xe MR imaging measurements and those from spirometry and plethysmography.

MATERIALS AND METHODS: This study was approved by an ethics board and compliant with HIPAA. Written informed consent was obtained from all subjects. Eight healthy volunteers and 10 patients with COPD underwent MR imaging, spirometry, and plethysmography. Ventilation defect percentages (VDPs) at 3He and 129Xe imaging were obtained by using semiautomated …

Cost-Effective Asthma Treatments For Uninsured Or Underinsured Pediatric Patients, Karlen E. (Beth) Luthy, Emilianne Dougall, Renea L. Beckstrand

Faculty Publications

Nurse practitioners should constantly compare a medication's potential effect with its associated cost, thus identifying the most cost-effective treatment plan. Such an approach is warranted for both pediatric and adult patients. Prescribing medications for children who are uninsured or underinsured can be especially challenging, particularly for those patients diagnosed with a chronic health condition requiring routine treatment and follow-up. Asthma can be such a chronic illness for which the cost associated with treatment may become a barrier to compliance with the treatment plan. Cost-effective treatment options for asthma in the pediatric patient are presented.

Are Dutch Patients Willing To Be Seen By A Physician Assistant Instead Of A Medical Doctor?, Luppo Kuilman, Roos M.B. Nieweg, Cees P. Van Der Schans, Jaap H. Strijbos, Roderick S. Hooker

Prevention and Community Health Faculty Publications

Background

The employment of physician assistants (PAs) is a strategy to improve access to care. Since the new millennium, a handful of countries have turned to PAs as a means to bridge the growing gap between the supply and demand of medical services. However, little is known about this new workforce entity from the patient’s perspective. The objective of this study was to assess the willingness of Dutch patients to be treated by a PA or a medical doctor (MD) under various time constraints and semi-urgent medical scenarios.

Methods

A total of 450 Dutch adults were recruited to act as …

2012 September 4 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

The Potential Impact Of Plain Packaging Of Cigarette Products Among Brazilian Young Women: An Experimental Study, Christine M/ White, David Hammond, Jim Thrasher, Geoffrey T. Fong

Faculty Publications

Background: Tobacco use is responsible for 5.4 million deaths every year worldwide and is a leading cause of preventable death. The burden of these deaths is rapidly shifting to low and middle-income countries, such as Brazil. Brazil has prohibited most forms of tobacco advertising; however, the cigarette pack remains a primary source of marketing. The current study examined how tobacco packaging influences brand appeal and perceptions of health risk among young women in Brazil.

Methods: A between-subjects experiment was conducted in which 640 Brazilian women aged 16–26 participated in an online survey. Participants were randomized to view 10 cigarette packages …

Ada News - 09/03/2012, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Superterry Destroys The Evil Monster Huntington’S Disease, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Situated Peer Coaching And Unfolding Cases In The Fundamentals Skills Laboratory, Deborah O. Himes, Patricia K. Ravert

Faculty Publications

Using unfolding case studies and situated peer coaching for the Fundamentals Skills Laboratory provides students with individualized feedback and creates a realistic clinical learning experience. A quasi-experimental design with pre- and post-intervention data was used to evaluate changes in student ratings of the course. An instrument was used to examine students' self-ratings and student comments about each lab. We found that students' ratings of the lab remained high with the new method and self-evaluations of their performance were higher as the semester progressed. Students appreciated the personalized feedback associated with peer coaching and demonstrated strong motivation and self-regulation in learning. …

Development Of Chinese Adolescents: Assessment, Issues, And Intervention, Daniel T. L. Shek, Rachel C. F. Sun, Joav Merrick

Pediatrics Faculty Publications

No abstract.

Life History Theory And Social Psychology., Donald F Sacco, Karol Osipowicz

Department of Neurology Faculty Papers

No abstract provided.

Situated Peer Coaching And Unfolding Cases In The Fundamentals Skills Laboratory, Deborah O. Himes, Patricia K. Ravert

Faculty Publications

Using unfolding case studies and situated peer coaching for the Fundamentals Skills Laboratory provides students with individualized feedback and creates a realistic clinical learning experience. A quasi-experimental design with pre- and post-intervention data was used to evaluate changes in student ratings of the course. An instrument was used to examine students' self-ratings and student comments about each lab. We found that students' ratings of the lab remained high with the new method and self-evaluations of their performance were higher as the semester progressed. Students appreciated the personalized feedback associated with peer coaching and demonstrated strong motivation and self-regulation in learning. …

The Causes, Treatment, And Outcome Of Acute Heart Failure In 1006 Africans From 9 Countries, Albertino Damasceno, Bongani M. Mayosi, Mahmoud Sani, Okechukwu S. Ogah, Charles Mondo, Dike Ojji, Anastase Dzudie, Charles Kouam Kouam, Ahmed Suliman, Neshaad Schrueder, Gerald Yonga, Serigne Abdou Ba, Fikru Maru, Bekele Alemayehu, Christopher Edwards, Beth A. Davison, Gad Cotter, Karen Sliwa

Internal Medicine, East Africa

Background: Acute heart failure (AHF) in sub-Saharan Africa has not been well characterized. Therefore,wesought to describe the characteristics, treatment, and outcomes of patients admitted with AHF in sub-Saharan Africa.

Methods: The Sub-Saharan Africa Survey of Heart Failure (THESUS–HF) was a prospective, multicenter, observational survey of patients with AHF admitted to 12 university hospitals in 9 countries. Among patients presenting with AHF, we determined the causes, treatment, and outcomes during 6 months of follow-up.

Results: From July 1, 2007, to June 30, 2010, we enrolled 1006 patients presenting with AHF. Mean (SD) age was 52.3 (18.3) years, 511 (50.8%) were women, …

Medical School Watercooler Newsletter - September 2, 2012, Lindsey Lyle

Watercooler Newsletter

This is the September 2, 2012 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• Biomedical Librarian Selected for Hospital Librarian of the Year Award
• Basic Medical Sciences Graduate Program Student Receives Edwin R. Hughes Award
• Patient Testimonial Ad a Success
• Dr. Molokhia Earns Master of Public Health Degree

Cicats Brochure 2012

Connecticut Institute for Clinical and Translational Science (CICATS)

The scientific mission of CICATS is to promote clinical and translational research of medical relevance applicable to the community. For this purpose, CICATS will:

Expedite the translation of new discoveries and foster clinical & translational research

Educate and mentor new scientists

Work collaboratively to reduce health care disparities

Looking In The Mouth For Noninvasive Gene Expression-Based Methods To Detect Oral, Oropharyngeal, And Systemic Cancer, Alexander J. Adami

UCHC Articles - Research

Noninvasive diagnosis, whether by sampling body fluids, body scans, or other technique, has the potential to simplify early cancer detection. A classic example is Pap smear screening, which has helped to reduce cervical cancer 75% over the last 50 years. No test is error-free; the real concern is sufficient accuracy combined with ease of use. This paper will discuss methods that measure gene expression or epigenetic markers in oral cells or saliva to diagnose oral and pharyngeal cancers, without requiring surgical biopsy. Evidence for lung and other distal cancer detection is also reviewed.

Herpes Simplex Viruses: Mechanisms Of Dna Replication, Sandra K. Weller

UCHC Articles - Research

Herpes simplex virus (HSV) encodes seven proteins necessary for viral DNA synthesis—UL9 (origin-binding protein), ICP8 (single-strand DNA [ssDNA]-binding protein), UL30/UL42 (polymerase), and UL5/UL8/UL52 (helicase/primase). It is our intention to provide an up-to-date analysis of our understanding of the structures of these replication proteins and how they function during HSV replication. The potential roles of host repair and recombination proteins will also be discussed.

Nf-Κb Contributes To The Detrimental Effects Of Social Isolation After Experimental Stroke, Venugopal Reddy Venna, Gillian Weston, Sharon E. Benashski, Sami Tarabishy, Fudong Liu, Jun Li, Lisa H. Conti, Louise D. Mccullough

UCHC Articles - Research

Social isolation (SI) is increasingly recognized as a risk factor for stroke. Individuals with lack of social support systems have an increased incidence of stroke, poorer recovery, and greater functional decline after injury compared to individuals with social support. Attesting to the importance of social factors in stroke outcome is that these same effects can be reproducibly demonstrated in animals; social interaction improves behavioral deficits and reduces damage after experimental stroke, whereas SI enhances injury. The mechanism by which SI exacerbates injury is unclear. We investigated the role of nuclear factor-kappaB (NF-κB) signaling in male mice that were pair housed …

Gabra2 Genotype, Impulsivity, And Body Mass, Lance O. Bauer

UCHC Articles - Research

Background

The goal of this study was to test a hypothesis associating impulsivity with an elevated body mass index (BMI).

Methods

To this end, we examined associations of BMI with putative genetic, neurophysiological, psychiatric, and psychological indicators of impulsivity in 78 women and 74 men formerly dependent on alcohol or drugs. A second analysis was designed to test the replicability of the genetic findings in an independent sample of 109 women and 111 men with a similar history of substance dependence.

Results

The results of the first analysis showed that BMI was positively correlated with Total and Nonplanning Scale Scores …

Medical Education Digest, Vol. 14 No. 5 (September/October 2012), Nova Southeastern University

Medical Education Digest

No abstract provided.