Medicine and Health Sciences Commons^™

Immediate Implant Placement In Extraction Sites With Periapical Lesions: A Retrospective Study, Yuan-Lung Hung

Loma Linda University Electronic Theses, Dissertations & Projects

Immediate implant placement into fresh extraction sites has become a relatively routine clinical procedure with a favorable prognosis. However, immediate placement into extraction sockets with lesions has not been extensively documented in humans. Therefore, the purpose of this study was to retrospectively determine the survival rate of implants placed into extraction sockets with visible periapical lesions.

Patient charts of 544 immediately placed implants from Loma Linda University School of Dentistry, Center for Prosthodontics and Implant Dentistry were examined. Eighty-six of the 544 implants had been placed immediately into extraction sockets with periapical lesions and they were included in this study. …

Is Electrical Stimulation A Predictive Tool For Autonomic Dysfunction In Males With Diabetes?, Susan Dorothy Rand

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to examine whether electrical stimulation can be used as a predictive tool to assess autonomic dysfunction in males with diabetes. The study was designed to better understand the extent of autonomic nervous system (ANS) dysfunction in the diabetic population.

Controls and patients with diabetes were recruited from the community at large and the Loma Linda University Diabetes Treatment Center and were managed by a physician. Twelve (12) people with diabetes and thirteen (13) control subjects participated. Mean age (years) for people with diabetes was 52.4 +/- 6.1 and 47.2 +/-11.1 for controls (p =0.05). …

Distraction Of Heterotopic Bone Formed With Bmp-2 In A Rat Model: The Technique, Stacie Dawn Fenderson

Loma Linda University Electronic Theses, Dissertations & Projects

Multiple studies have shown that ectopic bone forms when bone morphogenic proteins (for example BMP-2 and BMP-7) and a collagen matrix are surgically placed in a rat model either orthotopically or heterotopically. Bone begins to form by the 14 day, and is at it maximum calcified state by the 21st day. The purpose of this study is to observe and quantify the effect of distraction osteogenesis on the ectopic bone. First, a preliminary procedure was performed by surgically placing a titanium cage into the back of a rat just caudal to the thoracic vertebrae. The anterior corners were sutured to …

The Effects Of The Quadhelix Appliance On The Dentition And Adjacent Buccal Bone, Shannon Hilgers

Loma Linda University Electronic Theses, Dissertations & Projects

Maxillary palatal expansion has long been used in orthodontics as a means of correcting constricted and collapsed dental arches. The quadhelix appliance, developed by Drs. Robert Ricketts and Ruel Bench, expands buccal segments and causes distobuccal rotation in upper first molars. The objective of this study was to assess the direct effects that the quadhelix appliance on the surrounding dentition and buccal bone in the maxillary premolar and molar areas in a finite, measurable manner. This assessment was made using the NewTom 3G. The pre-quadhelix and post-quadhelix NewTom 3G images of twenty patients treated in the Graduate Orthodontic Clinic at …

Comparison Of Eight Prosthetic Aortic Valves In A Cadaver Model., Benjamin A. Youdelman, Hitoshi Hirose, Harsh Jain, J Yasha Kresh, John W.C. Entwistle, Andrew S. Wechsler

Department of Surgery Faculty Papers

OBJECTIVES: Proper valve selection is critical to ensure appropriate valve replacement for patients, because implantation of a small valve might place the patient at risk for persistent gradients. Labeled valve size is not the same as millimeter measure of prosthetic valve diameters or the annulus into which it will fit. Studies that use the labeled valve size in lieu of actual measured diameter in millimeters to compare different valves might be misleading. Using human cadaver hearts, we sized the aortic annulus with 8 commonly used prosthetic aortic valve sizers and compared the valves using geometric orifice area. This novel method …

Etiology And Disturbance Of Consciousnessin Stroke: A Hospital-Based Study, Hamzullah Khan, Muhammad Zarif

Pakistan Journal of Neurological Sciences (PJNS)

No abstract provided.

Traumatic Carotid-Cavernous Fistula:Clinical Presentation And Outcome, Atta A. Bhatti, S. Soulat Raza, Ehsan Bari, S. Ather Enam, Tanveer Ul Haq, Zafar Sajjad

Pakistan Journal of Neurological Sciences (PJNS)

No abstract provided.

Addressing Potential Conflicts Of Interest Arising From The Multiple Roles Of Colorado’S Community Centered Boards, Maureen Booth Mrp, Ma, Eileen Griffin Jd

Disability & Aging

This document summarizes the information we gathered, our analysis of potential conflicts of interest, and recommendations for addressing opportunities for improvement. The information we gathered is based on document review, input from stakeholders, and a review of practices in four other states.

A Novel Inhibitory Mechanism Of Mitochondrion-Dependent Apoptosis By A Herpesviral Protein, Pinghui Feng, Chengyu Liang, Young C. Shin, Xiaofei E, Weijun Zhang, Robyn Gravel, Ting-Ting Wu, Ren Sun, Edward Usherwood, Jae U. Jung

Dartmouth Scholarship

Upon viral infection, cells undergo apoptosis as a defense against viral replication. Viruses, in turn, have evolved elaborate mechanisms to subvert apoptotic processes. Here, we report that a novel viral mitochondrial anti-apoptotic protein (vMAP) of murine gamma-herpesvirus 68 (gammaHV-68) interacts with Bcl-2 and voltage-dependent anion channel 1 (VDAC1) in a genetically separable manner. The N-terminal region of vMAP interacted with Bcl-2, and this interaction markedly increased not only Bcl-2 recruitment to mitochondria but also its avidity for BH3-only pro-apoptotic proteins, thereby suppressing Bax mitochondrial translocation and activation. In addition, the central and C-terminal hydrophobic regions of vMAP interacted with VDAC1. …

Glucose-6-Phosphate Dehydrogenase (G6pd) Screening In Pakistani Neonates: To Be Or Not To Be, Bushra Moiz

Department of Pathology and Laboratory Medicine

No abstract provided.

Longitudinal Tracking Of Cytokines After Acute Exposure To Tuberculosis: Association Of Distinct Cytokine Patterns With Protection And Disease Development, Rabia Hussain, Najeeha Talat, Firdaus Shahid, Ghaffar Dawood

Department of Pathology and Laboratory Medicine

Household contacts (HCs) of patients with tuberculosis (TB) are at higher risk of infection as well as the development of active disease. Longitudinal tracking of antigen-specific cytokines after acute exposure may significantly advance our understanding of the dynamic changes in cytokine patterns associated with disease establishment. To achieve this objective, we carried out a prospective cohort study with healthy HCs after exposure to TB. The patterns of cytokines (gamma interferon [IFN-gamma] and interleukin 10 [IL-10]) in response to mycobacterial antigens (culture filtrate [CF] proteins) and nonspecific mitogens (phytohemagglutinin [PHA] and lipopolysaccharide [LPS]) were assessed at 0, 6, 12, and 24 …

An Investigation Of Relationship Characteristics, Exercise And Physical Activity, Couple And Life Satisfaction, Mark W. St. Martin

Dissertations

Exercise has been shown to be positively related to many different variables including sexual satisfaction, mental health, and physical health. These variables, in turn, have been linked to increased life satisfaction and couple satisfaction. The primary purpose of this study was to examine the relationships between exercise and couple satisfaction as well as exercise and life satisfaction. A secondary purpose was to replicate previous findings on the relationships between communication, love, sexual satisfaction, self-esteem, and physical health and couple satisfaction.

A total of 229 undergraduate and graduate students from a large Midwestern university in the United States participated in this …

The Long-Term Teratogenic Effect Of Prenatal Alcohol Exposure On The Somatosensory And Motor Cortex Of Rats, Tyson Chappell

Theses and Dissertations (ETD)

The primary goal of this dissertation was to examine the long-term effect of prenatal alcohol exposure (PAE) on the primary somatosensory (SI) and primary motor cortex (MI). For over 30 years, PAE has been shown to produce a triad of symptoms (growth deficits, craniofacial dysmorphologies and central nervous system disruptions) diagnosed as fetal alcohol syndrome (FAS) in children and adults. Since low to moderate levels of prenatal alcohol exposure are less likely to produce FAS symptoms in children, the term “PAE” in this dissertation typically refers to heavy/abusive/chronic levels of prenatal alcohol exposure (in humans this equates to 5+ drinks/per …

Development And Evaluation Of Brain Tumor Targeted Liposome Delivery System For Paclitaxel, Murali Krishna Divi

Theses and Dissertations (ETD)

Primary brain tumors are a relatively common cause of cancer-related deaths. High-grade gliomas are the most common type of primary brain cancer, and the affected patients have a median survival of less than 1 year. Almost all malignant gliomas are incurable with the present standards of healthcare. Currently accepted therapeutic adjuvants to surgery, such as radiotherapy and chemotherapy, provide only a minor improvement in the disease course and life expectancy for patients diagnosed with malignant gliomas. Often, chemotherapy has failed to make any significant impact on the prognosis of disease because of significant local and systemic toxicity, problems with transport …

Theoretical And Experimental Evaluation Of Spatial Resolution In A Variable Resolution X-Ray Computed Tomography Scanner, Roman Melnyk

Theses and Dissertations (ETD)

A variable resolution x-ray (VRX) computed tomography (CT) scanner can image objects of various sizes with greatly improved spatial resolution. The scanner employs an angulated discrete detector and achieves the resolution boost by matching the detector angulation to the scanner field of view (FOV) determined by the size of an object being imaged. A comprehensive evaluation of spatial resolution in an experimental version of the VRX CT scanner is presented in this dissertation. Two components of this resolution were evaluated – the pre-reconstruction spatial resolution, described by the detector presampling modulation transfer function (MTF), and the post-reconstruction spatial resolution, given …

Dna Binding Specificity Of Mu Transcription Factor C And Crystallization Of C : Dna Complex, Karthik Shanmugantham

Theses and Dissertations (ETD)

The lytic cycle of phage Mu is regulated by a transcriptional cascade consisting of early, middle and late transcription. The Mor protein is an activator of the middle promoter Pm and is encoded by the last gene of the early transcript. The C protein is an activator of the four late promoters Plys, PI, PP, and Pmom and is expressed from the middle transcript. Both Mor and C proteins bind an imperfect dyad-symmetry element just upstream and overlapping the –35 region of Pm and Plys respectively. The main aims of this study was, (1) To understand the binding specificity of …

Age-Associated Hepatic Drug Transporter Expression And Its Implications For Pediatric Pharmacotherapyflexibility Affect Dna Topoisomerase I Function, Lisa Tang

Theses and Dissertations (ETD)

Members of the ATP-binding cassette (ABC) family of drug transporter proteins translocate various endogenous and exogenous substrates across intra- and extracellular membranes. Two specific ABC transporters, the multidrug resistance 1/P-glycoprotein (MDR1/P-gp) and the multidrug resistance protein 2 (MRP2), serve as major hepatic transporters that mediate the biliary excretion of various organic anions and cations along with glutathione-, glucuronate-, or sulfate-conjugates of several drug substrates. However, very little is known about the expression of these transporters in the early infant and childhood ages of human development. We, therefore, characterized the ontogeny of these transporters by measuring their gene and protein expression. …

The Role Of Multi-Drug Resistance Associated Protein 4 And P-Glycoprotein In Resistance Of Neuroblastoma To Topotecan And Irinotecan, Patricia Kellie Turner

Theses and Dissertations (ETD)

High-risk neuroblastoma presents a significant therapeutic challenge because the 5-year survival rate remains less than 30% despite the use of surgery, multi-agent chemotherapy, radiation, and autologous bone marrow transplant. Novel therapeutic modalities are under development. The camptothecin analogs topotecan and irinotecan have been identified as successful cytotoxic agents. For topotecan, pharmacokinetically guided dosing to achieve a systemic exposure associated with preclinical anti-tumor activity in neuroblastoma xenograft models is feasible and has elicited favorable responses in children with high-risk neuroblastoma. However, some children with high-risk disease did not respond to the putatively effective topotecan systemic exposure. These children represent a subset …

Synthesis Of Novel Sulfonamide-Based Calpain Inhibitors And Their Potential As Anti-Tumor Agents, Jin Xu

Theses and Dissertations (ETD)

Calpain is a class of intracellular cytoplasmic cysteine proteases.1 The enzyme participates in different intracellular signaling pathways that are mediated by Ca2+.2 The two major isoforms of calpain universally distributed in most mammalian tissues are calpain 1 (µ-calpain) and calpain 2 (m-calpain). The exact in vivo function of the enzyme is not clear, but calpain has been implicated in a variety of physiological and pathological conditions,3 such as cancer, stroke, cardiac ischaemia, muscular dystrophy, cataract and Alzheimer’s disease. Calpain inhibitors are therefore of interest as therapeutic agents and as biomedical tools.

Several potent calpain inhibitors isolated from natural sources as …

Role Of Medial Prefrontal Cortical Group Ii Metabotropic Glutamate Receptor In The Development Of Cocaine Sensitization, Xiaohu Xie

Theses and Dissertations (ETD)

The current studies examined the role of medial prefrontal cortical (mPFC) group II metabotropic glutamate receptors (mGluR_2/3) in the development of cocaine sensitization. Initial studies demonstrated that intra-mPFC injection of the mGluR_2/3 receptor agonist, APDC, dose-dependently reduced acute behavioral response to cocaine (0.015-15 nmol/side with significant effects starting at 1.5nmol/side). The effects of APDC were prevented by intra-mPFC co-injections of an mGluR_2/3 antagonist, LY341495 (1.5 nmol/side). Repeated intra-mPFC APDC (1.5 nmol/side) injections also prevented the initiation of behavioral and neurochemical sensitization, which is defined as enhanced nucleus accumbens (NAc) dopamine response to cocaine. Once sensitization was …

Cardiopulmonary Predicators Of Dysfunctional Ventilator Weaning Response After Coronary Artery Bypass Graft, Annapoorna Mary

Theses and Dissertations (ETD)

Although the majority of coronary artery bypass graft (CABG) surgery patients are extubated within 6 to 8 hours following surgery, 20% to 40% of patients remain intubated 12 hours after surgery due to dysfunctional ventilator weaning response (DVWR). DVWR associated with increased morbidity and mortality (30% to 43%) following CABG surgery. Finding significant antecedence to predict DVWR could help to identify and prevent the complications from DVWR after CABG surgery. Literature review revealed that there is an association between cardiopulmonary indicators (CPI) and DVWR after CABG surgery. Cardiopulmonary indicators are the selected hemodynamic parameters that have an association with DVWR. …

Microsattellite Polymorphism And Parentage Control In Thai Domestic Elephants (Elephas Maximus), Duangsmorn Suwattana, Weerapong Koykul, Jutharat Jirasupphachok, Sumolya Kanchanapangka

The Thai Journal of Veterinary Medicine

Polymorphism of microsatellite DNA in Thai domestic elephants (Elephas maximus) was studied using five genetic markers including LaT05, LaT07, LaT16, LaT17 and LaT26, in order to determine the efficiency of such markers in parentage identification. Eleven elephants from 5 families and 10 unrelated ones located in the northern, northeastern and central parts of Thailand were tested. It was found that LaT05, LaT16, LaT17 and LaT26 possessed marker sizes of 250-500 bp with numbers of alleles ranging from 4-13, heterozygosity 0.62-0.88 and PIC 0.56-0.87 whereas LaT07 could not be detected in all specimens used. LaT05 and LaT26 appeared to be the …

The Effect Of Cold Storage On The Quality Of Stallion Semen And Pregnancy Rate After Artificial Insemination, Theerawat Tharasanit, Sukanya Manee-In, Pharaphon Khamenkhetwit, Sudson Sirivaidyapong, Chainarong Lohachit

The Thai Journal of Veterinary Medicine

While the use of frozen-thawed semen has been hampered by poor cryopreservability of equine sperm, the technique of choice in equine practice remains artificial insemination (AI) using cold storage semen. This study examined the effect of cold storage on semen quality and pregnancy rate after AI. In experiment I, ejaculates were collected from 3 stallions of proven fertility and then diluted to a final concentration of 25-50 x 106 sperm/ml. After transportation, the semen was then divided into two aliquots. The first part of semen was centrifuged to partially remove the seminal plasma, while the remaining was left intact with …

Ecg Quiz, Chollada Buranakarl, Kris Angkanaporn, Monkon Trisiriroj

The Thai Journal of Veterinary Medicine

No abstract provided.

Special Article: Physical Activity, Physical Fitness, And Cardiovascular Risk Factors In Childhood, Samuel S. Gidding

Department of Pediatrics Faculty Papers

In adults, physical activity and exercise training are associated with reduced cardiovascular morbidity and mortality, a reduced likelihood of developing adverse cardiovascular risk factors, and improved insulin sensitivity. In childhood, participation in appropriate physical activity may prevent the development of cardiovascular risk factors in the future and complement treatment of existing cardiovascular risk factors, including hypertension, dyslipidemia, and overweight. Exercise in children can also significantly improve insulin sensitivity independent of weight loss. These e fects are mediated in overweight children by increases in lean body mass relative to fat mass and associated improvements in inflammatory mediators, endothelial function, and the …

Child Maltreatment History And Subsequent Romantic Relationships: Exploring A Psychological Route To Dyadic Difficulties, David K. Dilillo, Terri Lewis, Andrea Di Loreto-Colgan

Department of Psychology: Faculty Publications

A sample of 174 college students involved in heterosexual dating relationships was studied lo investigate the role of psychological distress in mediating links between child maltreatment (CM) history and current couple functioning. Females, but not males, with a history of CM reported greater levels of psychological and relationship difficulties than did non-maltreated women. Psychological distress among females was also found to mediate associations between abuse history and various aspects of couple functioning including intimacy, sexuality. and conflict resolution. No such relationships were found for males. The implications of these results and suggestions for future research are discussed.

Book Review: Using Psychology To Make A Difference, Brian H. Bornstein

Department of Psychology: Faculty Publications

This is a book whose time has come. It collects papers presented at a symposium on applied psychology held at Claremont Graduate University, and that is fitting, as Claremont has one of the leading programs in applied psychology. Most of the chapter authors (8 of 15) are themselves Claremont faculty, and the editors have also gathered a number of impressive outside contributors, such as Philip Zimbardo, Albert Bandura, Robert Rosenthal, Diane Halpern, Stanley Sue, and Elizabeth Loft us. What all these individuals have in common is an interest in using psychology to better the human condition and, in the words …

Negative Mood Regulation Mediates The Relationship Between Distraction And Engagement In Pleasurable Activities Among College Smokers, Lee M. Cohen, Dennis E. Mcchargue, Holly E. R. Morrell

Department of Psychology: Faculty Publications

Smoking for negative mood alleviation is a strong predictor of early smoking and early dependence among undergraduates. Little is known about whether adaptive cognitive coping processes (e.g., distraction) may help decrease the likelihood of student smoking for negative mood regulation. The present study tested the hypothesis that distraction would predict (a) greater engagement in adaptive pleasant pastimes and (b) lower rates of smoking behavior among undergraduates (n = 162, 41.9% female). We further assessed whether negative mood regulation expectations would explain both relationships. Results indicated that negative mood regulation fully mediated the relationship between distraction and engagement in pleasurable …

Effect Of Endothelin 1 Genotype On Blood Pressure Is Dependent On Physical Activity Or Fitness Levels, Tuomo Rankinen, Timothy S. Church, Treva Rice, Nathan Markward, Arthur S. Leon, Dabeeru C. Rao, James S. Skinner, Steven N. Blair, Claude Bouchard

Faculty Publications

Contributions of the DNA sequence variation at the endothelin 1 locus to the risk of hypertension and to endurance training-induced changes in blood pressure were investigated in the Aerobics Center Longitudinal Study and the Health, Risk Factors, Exercise Training and Genetics Family Study cohorts. We identified 586 normotensive control subjects and 607 incident hypertensive case subjects from the Aerobics Center Longitudinal Study cohort (all whites) who were normotensive and healthy at their first clinical visit. The case subjects were diagnosed with hypertension during an average follow-up of 9.5 years, whereas the control subjects remained normotensive. The allele and genotype frequencies …

Perceived Organizational Support And Ethical Work Climates As Predictors Of Turnover Intention Of Licensed Nurses In Skilled Nursing Facilities, Anna A. Filipova

Dissertations

The purpose of this study was twofold: (1) to replicate Victor and Cullen's (1987; 1988) studies to confirm whether ethical climates (ECs) arise in skilled nursing facilities (SNFs), and whether organizations and groups within organizations have identifiable ECs; and (2) to test a model that examines the effects of ECs and perceived organizational support (POS) on licensed nurses' turnover intention (TOI) through job satisfaction (JS) and organizational commitment (OC).

A cross-sectional survey design was implemented. Three hundred and fifty nine freestanding SNFs were selected in a midwestern state. While a total of 110 facilities (31%) agreed to participate, responses were …